-- dump date   	20140619_152347
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
487521000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
487521000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521000003	Walker A motif; other site
487521000004	ATP binding site [chemical binding]; other site
487521000005	Walker B motif; other site
487521000006	arginine finger; other site
487521000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
487521000008	DnaA box-binding interface [nucleotide binding]; other site
487521000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
487521000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
487521000011	putative DNA binding surface [nucleotide binding]; other site
487521000012	dimer interface [polypeptide binding]; other site
487521000013	beta-clamp/clamp loader binding surface; other site
487521000014	beta-clamp/translesion DNA polymerase binding surface; other site
487521000015	recombination protein F; Reviewed; Region: recF; PRK00064
487521000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
487521000017	Walker A/P-loop; other site
487521000018	ATP binding site [chemical binding]; other site
487521000019	Q-loop/lid; other site
487521000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521000021	ABC transporter signature motif; other site
487521000022	Walker B; other site
487521000023	D-loop; other site
487521000024	H-loop/switch region; other site
487521000025	hypothetical protein; Provisional; Region: PRK03195
487521000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
487521000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521000028	Mg2+ binding site [ion binding]; other site
487521000029	G-X-G motif; other site
487521000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
487521000031	anchoring element; other site
487521000032	dimer interface [polypeptide binding]; other site
487521000033	ATP binding site [chemical binding]; other site
487521000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
487521000035	active site
487521000036	putative metal-binding site [ion binding]; other site
487521000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
487521000038	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
487521000039	CAP-like domain; other site
487521000040	active site
487521000041	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
487521000042	protein-splicing catalytic site; other site
487521000043	thioester formation/cholesterol transfer; other site
487521000044	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
487521000045	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
487521000046	DNA gyrase subunit A; Validated; Region: PRK05560
487521000047	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
487521000048	primary dimer interface [polypeptide binding]; other site
487521000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487521000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487521000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487521000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487521000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487521000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487521000055	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
487521000056	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000057	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000058	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521000059	Cytochrome P450; Region: p450; cl12078
487521000060	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
487521000061	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
487521000062	active site
487521000063	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
487521000064	putative septation inhibitor protein; Reviewed; Region: PRK00159
487521000065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
487521000066	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
487521000067	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
487521000068	Glutamine amidotransferase class-I; Region: GATase; pfam00117
487521000069	glutamine binding [chemical binding]; other site
487521000070	catalytic triad [active]
487521000071	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
487521000072	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521000073	active site
487521000074	ATP binding site [chemical binding]; other site
487521000075	substrate binding site [chemical binding]; other site
487521000076	activation loop (A-loop); other site
487521000077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
487521000078	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
487521000079	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
487521000080	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
487521000081	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
487521000082	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521000083	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521000084	active site
487521000085	ATP binding site [chemical binding]; other site
487521000086	substrate binding site [chemical binding]; other site
487521000087	activation loop (A-loop); other site
487521000088	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
487521000089	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
487521000090	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
487521000091	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
487521000092	active site
487521000093	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521000094	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521000095	phosphopeptide binding site; other site
487521000096	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
487521000097	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521000098	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521000099	phosphopeptide binding site; other site
487521000100	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521000101	Protein of unknown function (DUF664); Region: DUF664; pfam04978
487521000102	DinB superfamily; Region: DinB_2; pfam12867
487521000103	acyl carrier protein; Validated; Region: PRK05883
487521000104	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
487521000105	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521000106	acyl-activating enzyme (AAE) consensus motif; other site
487521000107	AMP binding site [chemical binding]; other site
487521000108	active site
487521000109	CoA binding site [chemical binding]; other site
487521000110	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
487521000111	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
487521000112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521000113	Coenzyme A binding pocket [chemical binding]; other site
487521000114	Pirin-related protein [General function prediction only]; Region: COG1741
487521000115	Pirin; Region: Pirin; pfam02678
487521000116	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
487521000117	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521000118	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521000119	active site
487521000120	Transcription factor WhiB; Region: Whib; pfam02467
487521000121	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487521000122	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521000123	non-specific DNA binding site [nucleotide binding]; other site
487521000124	salt bridge; other site
487521000125	sequence-specific DNA binding site [nucleotide binding]; other site
487521000126	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
487521000127	NlpC/P60 family; Region: NLPC_P60; pfam00877
487521000128	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
487521000129	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
487521000130	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
487521000131	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
487521000132	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
487521000133	TIGR03084 family protein; Region: TIGR03084
487521000134	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
487521000135	Wyosine base formation; Region: Wyosine_form; pfam08608
487521000136	H+ Antiporter protein; Region: 2A0121; TIGR00900
487521000137	hypothetical protein; Validated; Region: PRK00228
487521000138	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
487521000139	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
487521000140	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521000141	active site
487521000142	HIGH motif; other site
487521000143	nucleotide binding site [chemical binding]; other site
487521000144	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
487521000145	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521000146	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521000147	active site
487521000148	KMSKS motif; other site
487521000149	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
487521000150	tRNA binding surface [nucleotide binding]; other site
487521000151	short chain dehydrogenase; Provisional; Region: PRK08219
487521000152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521000153	NAD(P) binding site [chemical binding]; other site
487521000154	active site
487521000155	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521000156	MarR family; Region: MarR; pfam01047
487521000157	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
487521000158	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487521000159	Walker A/P-loop; other site
487521000160	ATP binding site [chemical binding]; other site
487521000161	Q-loop/lid; other site
487521000162	ABC transporter signature motif; other site
487521000163	Walker B; other site
487521000164	D-loop; other site
487521000165	H-loop/switch region; other site
487521000166	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487521000167	substrate binding pocket [chemical binding]; other site
487521000168	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487521000169	membrane-bound complex binding site; other site
487521000170	hinge residues; other site
487521000171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521000172	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
487521000173	dimer interface [polypeptide binding]; other site
487521000174	conserved gate region; other site
487521000175	putative PBP binding loops; other site
487521000176	ABC-ATPase subunit interface; other site
487521000177	Transcriptional regulators [Transcription]; Region: GntR; COG1802
487521000178	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521000179	DNA-binding site [nucleotide binding]; DNA binding site
487521000180	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
487521000181	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521000182	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521000183	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
487521000184	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
487521000185	active site
487521000186	FMN binding site [chemical binding]; other site
487521000187	substrate binding site [chemical binding]; other site
487521000188	putative catalytic residue [active]
487521000189	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521000190	NAD(P) binding site [chemical binding]; other site
487521000191	active site
487521000192	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521000193	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
487521000194	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
487521000195	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521000196	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521000197	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
487521000198	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
487521000199	Predicted transcriptional regulators [Transcription]; Region: COG1695
487521000200	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
487521000201	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
487521000202	Transglycosylase; Region: Transgly; pfam00912
487521000203	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
487521000204	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
487521000205	Predicted integral membrane protein [Function unknown]; Region: COG5650
487521000206	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
487521000207	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
487521000208	conserved cys residue [active]
487521000209	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
487521000210	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
487521000211	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
487521000212	dimer interface [polypeptide binding]; other site
487521000213	ssDNA binding site [nucleotide binding]; other site
487521000214	tetramer (dimer of dimers) interface [polypeptide binding]; other site
487521000215	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
487521000216	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
487521000217	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
487521000218	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
487521000219	replicative DNA helicase; Region: DnaB; TIGR00665
487521000220	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
487521000221	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
487521000222	Walker A motif; other site
487521000223	ATP binding site [chemical binding]; other site
487521000224	Walker B motif; other site
487521000225	DNA binding loops [nucleotide binding]
487521000226	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
487521000227	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521000228	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
487521000229	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
487521000230	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000231	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000232	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000233	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000234	Transport protein; Region: actII; TIGR00833
487521000235	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521000236	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
487521000237	DNA-binding site [nucleotide binding]; DNA binding site
487521000238	RNA-binding motif; other site
487521000239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521000240	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521000241	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
487521000242	classical (c) SDRs; Region: SDR_c; cd05233
487521000243	NAD(P) binding site [chemical binding]; other site
487521000244	active site
487521000245	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521000246	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521000247	NAD(P) binding site [chemical binding]; other site
487521000248	active site
487521000249	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521000250	Cytochrome P450; Region: p450; cl12078
487521000251	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521000252	short chain dehydrogenase; Provisional; Region: PRK08303
487521000253	NAD(P) binding site [chemical binding]; other site
487521000254	active site
487521000255	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000256	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000257	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
487521000258	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
487521000259	putative dimer interface [polypeptide binding]; other site
487521000260	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521000261	classical (c) SDRs; Region: SDR_c; cd05233
487521000262	NAD(P) binding site [chemical binding]; other site
487521000263	active site
487521000264	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
487521000265	FAD binding domain; Region: FAD_binding_4; pfam01565
487521000266	Berberine and berberine like; Region: BBE; pfam08031
487521000267	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
487521000268	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
487521000269	ligand binding site [chemical binding]; other site
487521000270	flexible hinge region; other site
487521000271	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
487521000272	putative switch regulator; other site
487521000273	non-specific DNA interactions [nucleotide binding]; other site
487521000274	DNA binding site [nucleotide binding]
487521000275	sequence specific DNA binding site [nucleotide binding]; other site
487521000276	putative cAMP binding site [chemical binding]; other site
487521000277	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521000278	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521000279	PGAP1-like protein; Region: PGAP1; pfam07819
487521000280	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
487521000281	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
487521000282	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
487521000283	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487521000284	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
487521000285	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521000286	active site
487521000287	Permease; Region: Permease; pfam02405
487521000288	Permease; Region: Permease; pfam02405
487521000289	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
487521000290	mce related protein; Region: MCE; pfam02470
487521000291	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
487521000292	mce related protein; Region: MCE; pfam02470
487521000293	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521000294	mce related protein; Region: MCE; pfam02470
487521000295	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521000296	mce related protein; Region: MCE; pfam02470
487521000297	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521000298	mce related protein; Region: MCE; pfam02470
487521000299	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
487521000300	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521000301	mce related protein; Region: MCE; pfam02470
487521000302	Mannan-binding protein; Region: MVL; pfam12151
487521000303	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000304	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000305	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000306	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000307	methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280
487521000308	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
487521000309	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521000310	PPE family; Region: PPE; pfam00823
487521000311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521000312	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521000313	S-adenosylmethionine binding site [chemical binding]; other site
487521000314	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521000315	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521000316	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521000317	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
487521000318	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
487521000319	Sulfate transporter family; Region: Sulfate_transp; pfam00916
487521000320	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521000321	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521000322	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
487521000323	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
487521000324	putative ligand binding site [chemical binding]; other site
487521000325	NAD binding site [chemical binding]; other site
487521000326	catalytic site [active]
487521000327	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
487521000328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
487521000329	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521000330	Cytochrome P450; Region: p450; cl12078
487521000331	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
487521000332	metal ion-dependent adhesion site (MIDAS); other site
487521000333	MoxR-like ATPases [General function prediction only]; Region: COG0714
487521000334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521000335	Walker A motif; other site
487521000336	ATP binding site [chemical binding]; other site
487521000337	Walker B motif; other site
487521000338	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
487521000339	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
487521000340	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000341	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521000342	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521000343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521000344	metabolite-proton symporter; Region: 2A0106; TIGR00883
487521000345	putative substrate translocation pore; other site
487521000346	Hemerythrin-like domain; Region: Hr-like; cd12108
487521000347	Fe binding site [ion binding]; other site
487521000348	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521000349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521000350	S-adenosylmethionine binding site [chemical binding]; other site
487521000351	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521000352	active site
487521000353	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
487521000354	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
487521000355	putative active site [active]
487521000356	putative CoA binding site [chemical binding]; other site
487521000357	nudix motif; other site
487521000358	metal binding site [ion binding]; metal-binding site
487521000359	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
487521000360	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
487521000361	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521000362	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521000363	Predicted transcriptional regulators [Transcription]; Region: COG1695
487521000364	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
487521000365	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
487521000366	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521000367	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
487521000368	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521000369	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
487521000370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521000371	hypothetical protein; Provisional; Region: PRK01346
487521000372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521000373	Coenzyme A binding pocket [chemical binding]; other site
487521000374	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521000375	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521000376	active site
487521000377	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000378	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000379	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521000380	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521000381	dimer interface [polypeptide binding]; other site
487521000382	phosphorylation site [posttranslational modification]
487521000383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521000384	ATP binding site [chemical binding]; other site
487521000385	Mg2+ binding site [ion binding]; other site
487521000386	G-X-G motif; other site
487521000387	PPE family; Region: PPE; pfam00823
487521000388	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
487521000389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
487521000390	EspG family; Region: ESX-1_EspG; pfam14011
487521000391	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
487521000392	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
487521000393	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
487521000394	catalytic residues [active]
487521000395	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
487521000396	catalytic residues [active]
487521000397	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
487521000398	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
487521000399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521000400	Walker A motif; other site
487521000401	ATP binding site [chemical binding]; other site
487521000402	Walker B motif; other site
487521000403	arginine finger; other site
487521000404	Domain of unknown function (DUF385); Region: DUF385; cl04387
487521000405	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
487521000406	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521000407	NAD(P) binding site [chemical binding]; other site
487521000408	active site
487521000409	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
487521000410	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521000411	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
487521000412	DNA binding residues [nucleotide binding]
487521000413	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
487521000414	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
487521000415	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
487521000416	active site
487521000417	dimer interface [polypeptide binding]; other site
487521000418	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
487521000419	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
487521000420	active site
487521000421	FMN binding site [chemical binding]; other site
487521000422	substrate binding site [chemical binding]; other site
487521000423	3Fe-4S cluster binding site [ion binding]; other site
487521000424	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
487521000425	domain interface; other site
487521000426	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
487521000427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521000428	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
487521000429	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521000430	hypothetical protein; Provisional; Region: PRK07945
487521000431	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
487521000432	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
487521000433	active site
487521000434	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
487521000435	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
487521000436	DNA polymerase IV; Validated; Region: PRK03858
487521000437	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
487521000438	active site
487521000439	DNA binding site [nucleotide binding]
487521000440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000442	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521000443	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521000444	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
487521000445	CopC domain; Region: CopC; pfam04234
487521000446	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
487521000447	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
487521000448	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
487521000449	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
487521000450	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
487521000451	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
487521000452	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
487521000453	putative active site [active]
487521000454	catalytic site [active]
487521000455	putative metal binding site [ion binding]; other site
487521000456	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
487521000457	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
487521000458	prephenate dehydratase; Provisional; Region: PRK11898
487521000459	Prephenate dehydratase; Region: PDT; pfam00800
487521000460	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
487521000461	putative L-Phe binding site [chemical binding]; other site
487521000462	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521000463	catalytic core [active]
487521000464	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
487521000465	Septum formation; Region: Septum_form; pfam13845
487521000466	Septum formation; Region: Septum_form; pfam13845
487521000467	seryl-tRNA synthetase; Provisional; Region: PRK05431
487521000468	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
487521000469	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
487521000470	dimer interface [polypeptide binding]; other site
487521000471	active site
487521000472	motif 1; other site
487521000473	motif 2; other site
487521000474	motif 3; other site
487521000475	Cupin domain; Region: Cupin_2; cl17218
487521000476	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521000477	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
487521000478	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521000479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521000480	S-adenosylmethionine binding site [chemical binding]; other site
487521000481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521000482	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
487521000483	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521000484	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000485	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
487521000486	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521000487	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
487521000488	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487521000489	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
487521000490	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521000491	iron-sulfur cluster [ion binding]; other site
487521000492	[2Fe-2S] cluster binding site [ion binding]; other site
487521000493	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521000494	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
487521000495	putative acyl-acceptor binding pocket; other site
487521000496	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521000497	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
487521000498	putative acyl-acceptor binding pocket; other site
487521000499	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521000500	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
487521000501	putative acyl-acceptor binding pocket; other site
487521000502	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521000503	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
487521000504	active site
487521000505	motif I; other site
487521000506	motif II; other site
487521000507	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521000508	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
487521000509	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
487521000510	amidase catalytic site [active]
487521000511	Zn binding residues [ion binding]; other site
487521000512	substrate binding site [chemical binding]; other site
487521000513	LGFP repeat; Region: LGFP; pfam08310
487521000514	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
487521000515	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521000516	UDP-galactopyranose mutase; Region: GLF; pfam03275
487521000517	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
487521000518	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487521000519	active site
487521000520	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487521000521	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
487521000522	Predicted esterase [General function prediction only]; Region: COG0627
487521000523	Putative esterase; Region: Esterase; pfam00756
487521000524	Cutinase; Region: Cutinase; pfam01083
487521000525	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
487521000526	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
487521000527	acyl-activating enzyme (AAE) consensus motif; other site
487521000528	active site
487521000529	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521000530	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521000531	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
487521000532	active site
487521000533	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
487521000534	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521000535	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521000536	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
487521000537	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
487521000538	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
487521000539	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521000540	RNA polymerase factor sigma-70; Validated; Region: PRK08241
487521000541	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521000542	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521000543	DNA binding residues [nucleotide binding]
487521000544	RibD C-terminal domain; Region: RibD_C; cl17279
487521000545	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521000546	active site
487521000547	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521000548	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
487521000549	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
487521000550	ligand binding site [chemical binding]; other site
487521000551	flexible hinge region; other site
487521000552	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
487521000553	putative switch regulator; other site
487521000554	non-specific DNA interactions [nucleotide binding]; other site
487521000555	DNA binding site [nucleotide binding]
487521000556	sequence specific DNA binding site [nucleotide binding]; other site
487521000557	putative cAMP binding site [chemical binding]; other site
487521000558	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521000559	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521000560	phosphopeptide binding site; other site
487521000561	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
487521000562	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
487521000563	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
487521000564	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
487521000565	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
487521000566	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
487521000567	putative hydrophobic ligand binding site [chemical binding]; other site
487521000568	CLM binding site; other site
487521000569	L1 loop; other site
487521000570	DNA binding site [nucleotide binding]
487521000571	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521000572	putative DNA binding site [nucleotide binding]; other site
487521000573	putative Zn2+ binding site [ion binding]; other site
487521000574	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
487521000575	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
487521000576	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
487521000577	short chain dehydrogenase; Provisional; Region: PRK07904
487521000578	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487521000579	NAD(P) binding site [chemical binding]; other site
487521000580	active site
487521000581	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
487521000582	FAD binding domain; Region: FAD_binding_4; pfam01565
487521000583	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
487521000584	Predicted membrane protein [Function unknown]; Region: COG2246
487521000585	GtrA-like protein; Region: GtrA; pfam04138
487521000586	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
487521000587	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
487521000588	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521000589	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521000590	active site
487521000591	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
487521000592	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
487521000593	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
487521000594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487521000595	active site
487521000596	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
487521000597	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
487521000598	Walker A/P-loop; other site
487521000599	ATP binding site [chemical binding]; other site
487521000600	Q-loop/lid; other site
487521000601	ABC transporter signature motif; other site
487521000602	Walker B; other site
487521000603	D-loop; other site
487521000604	H-loop/switch region; other site
487521000605	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
487521000606	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
487521000607	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521000608	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521000609	catalytic residue [active]
487521000610	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
487521000611	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
487521000612	NAD(P) binding site [chemical binding]; other site
487521000613	eRF1 domain 3; Region: eRF1_3; pfam03465
487521000614	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521000615	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521000616	enoyl-CoA hydratase; Provisional; Region: PRK06142
487521000617	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521000618	substrate binding site [chemical binding]; other site
487521000619	oxyanion hole (OAH) forming residues; other site
487521000620	trimer interface [polypeptide binding]; other site
487521000621	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
487521000622	TIGR03086 family protein; Region: TIGR03086
487521000623	GXWXG protein; Region: GXWXG; pfam14231
487521000624	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
487521000625	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
487521000626	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521000627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521000628	homodimer interface [polypeptide binding]; other site
487521000629	catalytic residue [active]
487521000630	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
487521000631	Phosphotransferase enzyme family; Region: APH; pfam01636
487521000632	putative active site [active]
487521000633	putative substrate binding site [chemical binding]; other site
487521000634	ATP binding site [chemical binding]; other site
487521000635	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521000636	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521000637	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521000638	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521000639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521000640	active site
487521000641	phosphorylation site [posttranslational modification]
487521000642	intermolecular recognition site; other site
487521000643	dimerization interface [polypeptide binding]; other site
487521000644	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521000645	DNA binding site [nucleotide binding]
487521000646	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521000647	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
487521000648	dimerization interface [polypeptide binding]; other site
487521000649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521000650	dimer interface [polypeptide binding]; other site
487521000651	phosphorylation site [posttranslational modification]
487521000652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521000653	ATP binding site [chemical binding]; other site
487521000654	Mg2+ binding site [ion binding]; other site
487521000655	G-X-G motif; other site
487521000656	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
487521000657	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
487521000658	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521000659	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
487521000660	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
487521000661	NAD(P) binding site [chemical binding]; other site
487521000662	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000663	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000664	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521000665	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521000666	active site
487521000667	short chain dehydrogenase; Provisional; Region: PRK07035
487521000668	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521000669	NAD(P) binding site [chemical binding]; other site
487521000670	active site
487521000671	Phosphotransferase enzyme family; Region: APH; pfam01636
487521000672	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
487521000673	putative active site [active]
487521000674	putative substrate binding site [chemical binding]; other site
487521000675	ATP binding site [chemical binding]; other site
487521000676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521000677	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521000678	catalytic core [active]
487521000679	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
487521000680	putative active site [active]
487521000681	putative substrate binding site [chemical binding]; other site
487521000682	ATP binding site [chemical binding]; other site
487521000683	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
487521000684	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
487521000685	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487521000686	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
487521000687	Walker A/P-loop; other site
487521000688	ATP binding site [chemical binding]; other site
487521000689	Q-loop/lid; other site
487521000690	ABC transporter signature motif; other site
487521000691	Walker B; other site
487521000692	D-loop; other site
487521000693	H-loop/switch region; other site
487521000694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
487521000695	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
487521000696	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
487521000697	prephenate dehydrogenase; Validated; Region: PRK06545
487521000698	prephenate dehydrogenase; Validated; Region: PRK08507
487521000699	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
487521000700	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
487521000701	nucleoside/Zn binding site; other site
487521000702	dimer interface [polypeptide binding]; other site
487521000703	catalytic motif [active]
487521000704	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
487521000705	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
487521000706	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
487521000707	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
487521000708	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
487521000709	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521000710	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521000711	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521000712	Transcriptional regulators [Transcription]; Region: GntR; COG1802
487521000713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521000714	DNA-binding site [nucleotide binding]; DNA binding site
487521000715	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
487521000716	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
487521000717	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
487521000718	active site
487521000719	non-prolyl cis peptide bond; other site
487521000720	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521000721	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521000722	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
487521000723	pyruvate carboxylase; Reviewed; Region: PRK12999
487521000724	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487521000725	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521000726	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
487521000727	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
487521000728	active site
487521000729	catalytic residues [active]
487521000730	metal binding site [ion binding]; metal-binding site
487521000731	homodimer binding site [polypeptide binding]; other site
487521000732	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
487521000733	carboxyltransferase (CT) interaction site; other site
487521000734	biotinylation site [posttranslational modification]; other site
487521000735	citrate synthase; Provisional; Region: PRK14033
487521000736	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
487521000737	dimer interface [polypeptide binding]; other site
487521000738	active site
487521000739	citrylCoA binding site [chemical binding]; other site
487521000740	oxalacetate/citrate binding site [chemical binding]; other site
487521000741	coenzyme A binding site [chemical binding]; other site
487521000742	catalytic triad [active]
487521000743	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
487521000744	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
487521000745	tetramer interface [polypeptide binding]; other site
487521000746	active site
487521000747	Mg2+/Mn2+ binding site [ion binding]; other site
487521000748	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
487521000749	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487521000750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521000751	non-specific DNA binding site [nucleotide binding]; other site
487521000752	salt bridge; other site
487521000753	sequence-specific DNA binding site [nucleotide binding]; other site
487521000754	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
487521000755	Domain of unknown function (DUF955); Region: DUF955; pfam06114
487521000756	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
487521000757	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
487521000758	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
487521000759	substrate binding site [chemical binding]; other site
487521000760	ATP binding site [chemical binding]; other site
487521000761	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
487521000762	dimerization interface [polypeptide binding]; other site
487521000763	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
487521000764	NAD binding site [chemical binding]; other site
487521000765	ligand binding site [chemical binding]; other site
487521000766	catalytic site [active]
487521000767	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521000768	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000769	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521000770	classical (c) SDRs; Region: SDR_c; cd05233
487521000771	NAD(P) binding site [chemical binding]; other site
487521000772	active site
487521000773	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521000774	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521000775	active site
487521000776	metal binding site [ion binding]; metal-binding site
487521000777	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521000778	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521000779	short chain dehydrogenase; Provisional; Region: PRK07856
487521000780	classical (c) SDRs; Region: SDR_c; cd05233
487521000781	NAD(P) binding site [chemical binding]; other site
487521000782	active site
487521000783	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521000784	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521000785	Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119
487521000786	nudix motif; other site
487521000787	haloalkane dehalogenase; Provisional; Region: PRK00870
487521000788	Cytochrome P450; Region: p450; cl12078
487521000789	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521000790	HTH-like domain; Region: HTH_21; pfam13276
487521000791	Integrase core domain; Region: rve; pfam00665
487521000792	Integrase core domain; Region: rve_3; pfam13683
487521000793	Transposase; Region: HTH_Tnp_1; cl17663
487521000794	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521000795	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521000796	active site
487521000797	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
487521000798	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
487521000799	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
487521000800	active site
487521000801	DNA binding site [nucleotide binding]
487521000802	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
487521000803	DNA binding site [nucleotide binding]
487521000804	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
487521000805	nucleotide binding site [chemical binding]; other site
487521000806	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
487521000807	Isochorismatase family; Region: Isochorismatase; pfam00857
487521000808	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
487521000809	catalytic triad [active]
487521000810	conserved cis-peptide bond; other site
487521000811	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521000812	Cytochrome P450; Region: p450; cl12078
487521000813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521000814	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521000815	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
487521000816	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
487521000817	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521000818	NAD(P) binding site [chemical binding]; other site
487521000819	active site
487521000820	Cutinase; Region: Cutinase; pfam01083
487521000821	CsbD-like; Region: CsbD; pfam05532
487521000822	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521000823	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521000824	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521000825	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521000826	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
487521000827	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521000828	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521000829	catalytic residue [active]
487521000830	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
487521000831	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521000832	Walker A motif; other site
487521000833	ATP binding site [chemical binding]; other site
487521000834	Walker B motif; other site
487521000835	arginine finger; other site
487521000836	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
487521000837	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521000838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521000839	S-adenosylmethionine binding site [chemical binding]; other site
487521000840	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
487521000841	FAD binding domain; Region: FAD_binding_4; pfam01565
487521000842	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
487521000843	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
487521000844	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
487521000845	active site
487521000846	metal binding site [ion binding]; metal-binding site
487521000847	hypothetical protein; Validated; Region: PRK00153
487521000848	recombination protein RecR; Reviewed; Region: recR; PRK00076
487521000849	RecR protein; Region: RecR; pfam02132
487521000850	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
487521000851	putative active site [active]
487521000852	putative metal-binding site [ion binding]; other site
487521000853	tetramer interface [polypeptide binding]; other site
487521000854	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
487521000855	catalytic triad [active]
487521000856	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
487521000857	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487521000858	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
487521000859	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
487521000860	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
487521000861	active site
487521000862	catalytic site [active]
487521000863	substrate binding site [chemical binding]; other site
487521000864	2-isopropylmalate synthase; Validated; Region: PRK03739
487521000865	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
487521000866	active site
487521000867	catalytic residues [active]
487521000868	metal binding site [ion binding]; metal-binding site
487521000869	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
487521000870	aspartate kinase; Reviewed; Region: PRK06635
487521000871	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
487521000872	putative nucleotide binding site [chemical binding]; other site
487521000873	putative catalytic residues [active]
487521000874	putative Mg ion binding site [ion binding]; other site
487521000875	putative aspartate binding site [chemical binding]; other site
487521000876	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
487521000877	putative allosteric regulatory site; other site
487521000878	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
487521000879	putative allosteric regulatory residue; other site
487521000880	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
487521000881	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
487521000882	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
487521000883	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521000884	ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444
487521000885	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
487521000886	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
487521000887	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
487521000888	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
487521000889	putative active site [active]
487521000890	putative dimer interface [polypeptide binding]; other site
487521000891	Uncharacterized conserved protein [Function unknown]; Region: COG4301
487521000892	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
487521000893	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521000894	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
487521000895	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521000896	catalytic residue [active]
487521000897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521000898	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521000899	S-adenosylmethionine binding site [chemical binding]; other site
487521000900	glycerol kinase; Provisional; Region: glpK; PRK00047
487521000901	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
487521000902	N- and C-terminal domain interface [polypeptide binding]; other site
487521000903	active site
487521000904	MgATP binding site [chemical binding]; other site
487521000905	catalytic site [active]
487521000906	metal binding site [ion binding]; metal-binding site
487521000907	putative homotetramer interface [polypeptide binding]; other site
487521000908	glycerol binding site [chemical binding]; other site
487521000909	homodimer interface [polypeptide binding]; other site
487521000910	Predicted transcriptional regulators [Transcription]; Region: COG1695
487521000911	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
487521000912	Predicted membrane protein/domain [Function unknown]; Region: COG1714
487521000913	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
487521000914	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
487521000915	Protein of unknown function DUF58; Region: DUF58; pfam01882
487521000916	MoxR-like ATPases [General function prediction only]; Region: COG0714
487521000917	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521000918	Walker A motif; other site
487521000919	ATP binding site [chemical binding]; other site
487521000920	Walker B motif; other site
487521000921	arginine finger; other site
487521000922	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
487521000923	Uncharacterized conserved protein [Function unknown]; Region: COG1610
487521000924	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
487521000925	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521000926	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
487521000927	intracellular protease, PfpI family; Region: PfpI; TIGR01382
487521000928	proposed catalytic triad [active]
487521000929	conserved cys residue [active]
487521000930	putative methyltransferase; Provisional; Region: PRK14967
487521000931	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521000932	S-adenosylmethionine binding site [chemical binding]; other site
487521000933	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
487521000934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
487521000935	PAS domain; Region: PAS_9; pfam13426
487521000936	putative active site [active]
487521000937	heme pocket [chemical binding]; other site
487521000938	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
487521000939	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
487521000940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
487521000941	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
487521000942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521000943	ATP binding site [chemical binding]; other site
487521000944	Mg2+ binding site [ion binding]; other site
487521000945	G-X-G motif; other site
487521000946	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
487521000947	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
487521000948	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
487521000949	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521000950	anti sigma factor interaction site; other site
487521000951	regulatory phosphorylation site [posttranslational modification]; other site
487521000952	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
487521000953	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
487521000954	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521000955	motif II; other site
487521000956	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
487521000957	Restriction endonuclease; Region: Mrr_cat; pfam04471
487521000958	GAF domain; Region: GAF; cl17456
487521000959	GAF domain; Region: GAF_2; pfam13185
487521000960	ANTAR domain; Region: ANTAR; pfam03861
487521000961	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
487521000962	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
487521000963	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521000964	catalytic residue [active]
487521000965	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
487521000966	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
487521000967	putative active site [active]
487521000968	putative metal binding site [ion binding]; other site
487521000969	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
487521000970	Transglycosylase; Region: Transgly; pfam00912
487521000971	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
487521000972	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
487521000973	Transcription factor WhiB; Region: Whib; pfam02467
487521000974	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
487521000975	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
487521000976	DTAP/Switch II; other site
487521000977	Switch I; other site
487521000978	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
487521000979	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
487521000980	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
487521000981	P loop; other site
487521000982	Nucleotide binding site [chemical binding]; other site
487521000983	DTAP/Switch II; other site
487521000984	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
487521000985	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
487521000986	homotrimer interaction site [polypeptide binding]; other site
487521000987	putative active site [active]
487521000988	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
487521000989	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
487521000990	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
487521000991	ligand binding site [chemical binding]; other site
487521000992	flexible hinge region; other site
487521000993	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
487521000994	putative switch regulator; other site
487521000995	non-specific DNA interactions [nucleotide binding]; other site
487521000996	DNA binding site [nucleotide binding]
487521000997	sequence specific DNA binding site [nucleotide binding]; other site
487521000998	putative cAMP binding site [chemical binding]; other site
487521000999	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
487521001000	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
487521001001	minor groove reading motif; other site
487521001002	helix-hairpin-helix signature motif; other site
487521001003	substrate binding pocket [chemical binding]; other site
487521001004	active site
487521001005	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
487521001006	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
487521001007	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487521001008	catalytic residues [active]
487521001009	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
487521001010	putative active site [active]
487521001011	putative CoA binding site [chemical binding]; other site
487521001012	nudix motif; other site
487521001013	metal binding site [ion binding]; metal-binding site
487521001014	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
487521001015	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
487521001016	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521001017	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
487521001018	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
487521001019	acetyl-CoA synthetase; Provisional; Region: PRK00174
487521001020	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
487521001021	active site
487521001022	CoA binding site [chemical binding]; other site
487521001023	acyl-activating enzyme (AAE) consensus motif; other site
487521001024	AMP binding site [chemical binding]; other site
487521001025	acetate binding site [chemical binding]; other site
487521001026	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
487521001027	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
487521001028	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
487521001029	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
487521001030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521001031	dimer interface [polypeptide binding]; other site
487521001032	conserved gate region; other site
487521001033	ABC-ATPase subunit interface; other site
487521001034	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
487521001035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521001036	dimer interface [polypeptide binding]; other site
487521001037	conserved gate region; other site
487521001038	putative PBP binding loops; other site
487521001039	ABC-ATPase subunit interface; other site
487521001040	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
487521001041	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
487521001042	Walker A/P-loop; other site
487521001043	ATP binding site [chemical binding]; other site
487521001044	Q-loop/lid; other site
487521001045	ABC transporter signature motif; other site
487521001046	Walker B; other site
487521001047	D-loop; other site
487521001048	H-loop/switch region; other site
487521001049	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
487521001050	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
487521001051	Walker A/P-loop; other site
487521001052	ATP binding site [chemical binding]; other site
487521001053	Q-loop/lid; other site
487521001054	ABC transporter signature motif; other site
487521001055	Walker B; other site
487521001056	D-loop; other site
487521001057	H-loop/switch region; other site
487521001058	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
487521001059	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
487521001060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521001061	motif II; other site
487521001062	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
487521001063	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
487521001064	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
487521001065	ATP binding site [chemical binding]; other site
487521001066	Walker A motif; other site
487521001067	hexamer interface [polypeptide binding]; other site
487521001068	Walker B motif; other site
487521001069	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
487521001070	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
487521001071	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
487521001072	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521001073	ATP binding site [chemical binding]; other site
487521001074	putative Mg++ binding site [ion binding]; other site
487521001075	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521001076	nucleotide binding region [chemical binding]; other site
487521001077	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
487521001078	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
487521001079	DNA-binding site [nucleotide binding]; DNA binding site
487521001080	RNA-binding motif; other site
487521001081	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
487521001082	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
487521001083	active site
487521001084	interdomain interaction site; other site
487521001085	putative metal-binding site [ion binding]; other site
487521001086	nucleotide binding site [chemical binding]; other site
487521001087	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
487521001088	domain I; other site
487521001089	phosphate binding site [ion binding]; other site
487521001090	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
487521001091	domain II; other site
487521001092	domain III; other site
487521001093	nucleotide binding site [chemical binding]; other site
487521001094	DNA binding groove [nucleotide binding]
487521001095	catalytic site [active]
487521001096	domain IV; other site
487521001097	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
487521001098	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
487521001099	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
487521001100	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521001101	dimerization interface [polypeptide binding]; other site
487521001102	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521001103	cyclase homology domain; Region: CHD; cd07302
487521001104	nucleotidyl binding site; other site
487521001105	metal binding site [ion binding]; metal-binding site
487521001106	dimer interface [polypeptide binding]; other site
487521001107	DNA polymerase III subunit delta'; Validated; Region: PRK07940
487521001108	DNA polymerase III subunit delta'; Validated; Region: PRK08485
487521001109	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521001110	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001111	NAD(P) binding site [chemical binding]; other site
487521001112	active site
487521001113	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
487521001114	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
487521001115	Ligand binding site; other site
487521001116	Putative Catalytic site; other site
487521001117	DXD motif; other site
487521001118	Protein of unknown function (DUF475); Region: DUF475; pfam04332
487521001119	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
487521001120	dimer interface [polypeptide binding]; other site
487521001121	substrate binding site [chemical binding]; other site
487521001122	metal binding sites [ion binding]; metal-binding site
487521001123	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
487521001124	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
487521001125	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
487521001126	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
487521001127	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
487521001128	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
487521001129	Ligand Binding Site [chemical binding]; other site
487521001130	TilS substrate binding domain; Region: TilS; pfam09179
487521001131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521001132	active site
487521001133	Uncharacterized conserved protein [Function unknown]; Region: COG2968
487521001134	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
487521001135	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521001136	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487521001137	salt bridge; other site
487521001138	non-specific DNA binding site [nucleotide binding]; other site
487521001139	sequence-specific DNA binding site [nucleotide binding]; other site
487521001140	PE family; Region: PE; pfam00934
487521001141	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521001142	PPE family; Region: PPE; pfam00823
487521001143	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521001144	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521001145	active site
487521001146	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521001147	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
487521001148	putative NAD(P) binding site [chemical binding]; other site
487521001149	catalytic Zn binding site [ion binding]; other site
487521001150	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521001151	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
487521001152	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521001153	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521001154	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487521001155	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521001156	active site
487521001157	metal binding site [ion binding]; metal-binding site
487521001158	FtsH Extracellular; Region: FtsH_ext; pfam06480
487521001159	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
487521001160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521001161	Walker A motif; other site
487521001162	ATP binding site [chemical binding]; other site
487521001163	Walker B motif; other site
487521001164	arginine finger; other site
487521001165	Peptidase family M41; Region: Peptidase_M41; pfam01434
487521001166	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
487521001167	homodecamer interface [polypeptide binding]; other site
487521001168	GTP cyclohydrolase I; Provisional; Region: PLN03044
487521001169	active site
487521001170	putative catalytic site residues [active]
487521001171	zinc binding site [ion binding]; other site
487521001172	GTP-CH-I/GFRP interaction surface; other site
487521001173	dihydropteroate synthase; Region: DHPS; TIGR01496
487521001174	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
487521001175	substrate binding pocket [chemical binding]; other site
487521001176	dimer interface [polypeptide binding]; other site
487521001177	inhibitor binding site; inhibition site
487521001178	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
487521001179	active site
487521001180	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
487521001181	catalytic center binding site [active]
487521001182	ATP binding site [chemical binding]; other site
487521001183	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
487521001184	Rossmann-like domain; Region: Rossmann-like; pfam10727
487521001185	Uncharacterized conserved protein [Function unknown]; Region: COG5495
487521001186	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
487521001187	Pantoate-beta-alanine ligase; Region: PanC; cd00560
487521001188	pantoate--beta-alanine ligase; Region: panC; TIGR00018
487521001189	active site
487521001190	ATP-binding site [chemical binding]; other site
487521001191	pantoate-binding site; other site
487521001192	HXXH motif; other site
487521001193	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
487521001194	tetramerization interface [polypeptide binding]; other site
487521001195	active site
487521001196	pantothenate kinase; Reviewed; Region: PRK13318
487521001197	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
487521001198	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
487521001199	dimer interface [polypeptide binding]; other site
487521001200	putative anticodon binding site; other site
487521001201	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
487521001202	motif 1; other site
487521001203	dimer interface [polypeptide binding]; other site
487521001204	active site
487521001205	motif 2; other site
487521001206	motif 3; other site
487521001207	Lsr2; Region: Lsr2; pfam11774
487521001208	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
487521001209	Clp amino terminal domain; Region: Clp_N; pfam02861
487521001210	Clp amino terminal domain; Region: Clp_N; pfam02861
487521001211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521001212	Walker A motif; other site
487521001213	ATP binding site [chemical binding]; other site
487521001214	Walker B motif; other site
487521001215	arginine finger; other site
487521001216	UvrB/uvrC motif; Region: UVR; pfam02151
487521001217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521001218	Walker A motif; other site
487521001219	ATP binding site [chemical binding]; other site
487521001220	Walker B motif; other site
487521001221	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
487521001222	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
487521001223	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
487521001224	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
487521001225	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521001226	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
487521001227	catalytic site [active]
487521001228	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
487521001229	minor groove reading motif; other site
487521001230	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
487521001231	helix-hairpin-helix signature motif; other site
487521001232	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
487521001233	active site clefts [active]
487521001234	zinc binding site [ion binding]; other site
487521001235	dimer interface [polypeptide binding]; other site
487521001236	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
487521001237	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
487521001238	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
487521001239	DNA repair protein RadA; Provisional; Region: PRK11823
487521001240	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
487521001241	Walker A motif/ATP binding site; other site
487521001242	ATP binding site [chemical binding]; other site
487521001243	Walker B motif; other site
487521001244	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
487521001245	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
487521001246	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
487521001247	substrate binding site; other site
487521001248	dimer interface; other site
487521001249	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
487521001250	homotrimer interaction site [polypeptide binding]; other site
487521001251	zinc binding site [ion binding]; other site
487521001252	CDP-binding sites; other site
487521001253	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
487521001254	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521001255	active site
487521001256	HIGH motif; other site
487521001257	nucleotide binding site [chemical binding]; other site
487521001258	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
487521001259	KMSKS motif; other site
487521001260	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
487521001261	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
487521001262	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
487521001263	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
487521001264	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
487521001265	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
487521001266	active site
487521001267	catalytic site [active]
487521001268	metal binding site [ion binding]; metal-binding site
487521001269	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
487521001270	transmembrane helices; other site
487521001271	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487521001272	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
487521001273	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
487521001274	putative active site [active]
487521001275	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521001276	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
487521001277	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
487521001278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521001279	Walker A/P-loop; other site
487521001280	ATP binding site [chemical binding]; other site
487521001281	Q-loop/lid; other site
487521001282	ABC transporter signature motif; other site
487521001283	Walker B; other site
487521001284	D-loop; other site
487521001285	H-loop/switch region; other site
487521001286	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
487521001287	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
487521001288	intersubunit interface [polypeptide binding]; other site
487521001289	Transcriptional regulators [Transcription]; Region: PurR; COG1609
487521001290	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487521001291	DNA binding site [nucleotide binding]
487521001292	domain linker motif; other site
487521001293	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
487521001294	putative dimerization interface [polypeptide binding]; other site
487521001295	putative ligand binding site [chemical binding]; other site
487521001296	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001297	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001298	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001299	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521001300	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001301	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001302	active site
487521001303	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001304	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001305	active site
487521001306	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521001307	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001308	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
487521001309	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521001310	putative NAD(P) binding site [chemical binding]; other site
487521001311	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
487521001312	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
487521001313	FAD binding pocket [chemical binding]; other site
487521001314	FAD binding motif [chemical binding]; other site
487521001315	phosphate binding motif [ion binding]; other site
487521001316	beta-alpha-beta structure motif; other site
487521001317	NAD(p) ribose binding residues [chemical binding]; other site
487521001318	NAD binding pocket [chemical binding]; other site
487521001319	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
487521001320	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521001321	catalytic loop [active]
487521001322	iron binding site [ion binding]; other site
487521001323	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001324	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
487521001325	Flavin binding site [chemical binding]; other site
487521001326	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
487521001327	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
487521001328	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
487521001329	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
487521001330	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
487521001331	active site
487521001332	Fe binding site [ion binding]; other site
487521001333	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
487521001334	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
487521001335	aspartate aminotransferase; Provisional; Region: PRK05764
487521001336	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521001337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521001338	homodimer interface [polypeptide binding]; other site
487521001339	catalytic residue [active]
487521001340	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521001341	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001342	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001343	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
487521001344	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521001345	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001346	active site
487521001347	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001348	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001349	active site
487521001350	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
487521001351	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521001352	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
487521001353	acyl-activating enzyme (AAE) consensus motif; other site
487521001354	acyl-activating enzyme (AAE) consensus motif; other site
487521001355	putative AMP binding site [chemical binding]; other site
487521001356	putative active site [active]
487521001357	putative CoA binding site [chemical binding]; other site
487521001358	CoA binding site [chemical binding]; other site
487521001359	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001360	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001361	active site
487521001362	short chain dehydrogenase; Provisional; Region: PRK07831
487521001363	classical (c) SDRs; Region: SDR_c; cd05233
487521001364	NAD(P) binding site [chemical binding]; other site
487521001365	active site
487521001366	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001367	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001368	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
487521001369	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
487521001370	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521001371	dimer interface [polypeptide binding]; other site
487521001372	active site
487521001373	Nitronate monooxygenase; Region: NMO; pfam03060
487521001374	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521001375	FMN binding site [chemical binding]; other site
487521001376	substrate binding site [chemical binding]; other site
487521001377	putative catalytic residue [active]
487521001378	Coenzyme A transferase; Region: CoA_trans; cl17247
487521001379	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
487521001380	enoyl-CoA hydratase; Provisional; Region: PRK06495
487521001381	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521001382	substrate binding site [chemical binding]; other site
487521001383	oxyanion hole (OAH) forming residues; other site
487521001384	trimer interface [polypeptide binding]; other site
487521001385	short chain dehydrogenase; Provisional; Region: PRK07856
487521001386	classical (c) SDRs; Region: SDR_c; cd05233
487521001387	NAD(P) binding site [chemical binding]; other site
487521001388	active site
487521001389	short chain dehydrogenase; Provisional; Region: PRK07791
487521001390	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001391	NAD(P) binding site [chemical binding]; other site
487521001392	active site
487521001393	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521001394	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521001395	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
487521001396	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521001397	dimer interface [polypeptide binding]; other site
487521001398	active site
487521001399	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521001400	Cytochrome P450; Region: p450; cl12078
487521001401	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001402	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521001403	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001404	active site
487521001405	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001406	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001407	active site
487521001408	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
487521001409	active site
487521001410	catalytic site [active]
487521001411	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
487521001412	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521001413	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
487521001414	putative active site [active]
487521001415	putative catalytic site [active]
487521001416	lipid-transfer protein; Provisional; Region: PRK07855
487521001417	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521001418	active site
487521001419	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
487521001420	putative active site [active]
487521001421	enoyl-CoA hydratase; Region: PLN02864
487521001422	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
487521001423	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
487521001424	dimer interaction site [polypeptide binding]; other site
487521001425	substrate-binding tunnel; other site
487521001426	active site
487521001427	catalytic site [active]
487521001428	substrate binding site [chemical binding]; other site
487521001429	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
487521001430	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
487521001431	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
487521001432	acetaldehyde dehydrogenase; Validated; Region: PRK08300
487521001433	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
487521001434	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
487521001435	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
487521001436	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
487521001437	active site
487521001438	catalytic residues [active]
487521001439	metal binding site [ion binding]; metal-binding site
487521001440	DmpG-like communication domain; Region: DmpG_comm; pfam07836
487521001441	short chain dehydrogenase; Provisional; Region: PRK07890
487521001442	classical (c) SDRs; Region: SDR_c; cd05233
487521001443	NAD(P) binding site [chemical binding]; other site
487521001444	active site
487521001445	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
487521001446	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
487521001447	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521001448	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
487521001449	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
487521001450	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
487521001451	trimer interface [polypeptide binding]; other site
487521001452	putative metal binding site [ion binding]; other site
487521001453	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521001454	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
487521001455	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521001456	active site
487521001457	lipid-transfer protein; Provisional; Region: PRK07937
487521001458	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521001459	active site
487521001460	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
487521001461	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
487521001462	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521001463	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521001464	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
487521001465	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
487521001466	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521001467	Cytochrome P450; Region: p450; cl12078
487521001468	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
487521001469	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
487521001470	putative active site [active]
487521001471	enoyl-CoA hydratase; Provisional; Region: PRK07799
487521001472	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521001473	substrate binding site [chemical binding]; other site
487521001474	oxyanion hole (OAH) forming residues; other site
487521001475	trimer interface [polypeptide binding]; other site
487521001476	acyl-CoA synthetase; Validated; Region: PRK07798
487521001477	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521001478	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
487521001479	acyl-activating enzyme (AAE) consensus motif; other site
487521001480	acyl-activating enzyme (AAE) consensus motif; other site
487521001481	putative AMP binding site [chemical binding]; other site
487521001482	putative active site [active]
487521001483	putative CoA binding site [chemical binding]; other site
487521001484	Fructosamine kinase; Region: Fructosamin_kin; cl17579
487521001485	Phosphotransferase enzyme family; Region: APH; pfam01636
487521001486	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
487521001487	hypothetical protein; Validated; Region: PRK07586
487521001488	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487521001489	PYR/PP interface [polypeptide binding]; other site
487521001490	dimer interface [polypeptide binding]; other site
487521001491	TPP binding site [chemical binding]; other site
487521001492	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
487521001493	TPP-binding site [chemical binding]; other site
487521001494	dimer interface [polypeptide binding]; other site
487521001495	acyl-CoA synthetase; Validated; Region: PRK07867
487521001496	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
487521001497	acyl-activating enzyme (AAE) consensus motif; other site
487521001498	putative AMP binding site [chemical binding]; other site
487521001499	putative active site [active]
487521001500	putative CoA binding site [chemical binding]; other site
487521001501	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001502	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521001503	active site
487521001504	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001505	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
487521001506	FAD binding site [chemical binding]; other site
487521001507	substrate binding site [chemical binding]; other site
487521001508	catalytic base [active]
487521001509	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
487521001510	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
487521001511	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
487521001512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001513	NAD(P) binding site [chemical binding]; other site
487521001514	active site
487521001515	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521001516	Permease; Region: Permease; pfam02405
487521001517	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521001518	Permease; Region: Permease; pfam02405
487521001519	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521001520	mce related protein; Region: MCE; pfam02470
487521001521	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521001522	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521001523	mce related protein; Region: MCE; pfam02470
487521001524	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521001525	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521001526	mce related protein; Region: MCE; pfam02470
487521001527	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
487521001528	mce related protein; Region: MCE; pfam02470
487521001529	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521001530	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521001531	mce related protein; Region: MCE; pfam02470
487521001532	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521001533	mce related protein; Region: MCE; pfam02470
487521001534	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
487521001535	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
487521001536	active site
487521001537	homotetramer interface [polypeptide binding]; other site
487521001538	enoyl-CoA hydratase; Provisional; Region: PRK08290
487521001539	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521001540	substrate binding site [chemical binding]; other site
487521001541	oxyanion hole (OAH) forming residues; other site
487521001542	trimer interface [polypeptide binding]; other site
487521001543	short chain dehydrogenase; Provisional; Region: PRK05875
487521001544	classical (c) SDRs; Region: SDR_c; cd05233
487521001545	NAD(P) binding site [chemical binding]; other site
487521001546	active site
487521001547	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521001548	classical (c) SDRs; Region: SDR_c; cd05233
487521001549	NAD(P) binding site [chemical binding]; other site
487521001550	active site
487521001551	Transcriptional regulator [Transcription]; Region: LytR; COG1316
487521001552	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
487521001553	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
487521001554	Amidase; Region: Amidase; cl11426
487521001555	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521001556	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
487521001557	Peptidase family S64; Region: Peptidase_S64; pfam08192
487521001558	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
487521001559	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
487521001560	N-acetyl-D-glucosamine binding site [chemical binding]; other site
487521001561	catalytic residue [active]
487521001562	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521001563	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521001564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521001565	active site
487521001566	phosphorylation site [posttranslational modification]
487521001567	intermolecular recognition site; other site
487521001568	dimerization interface [polypeptide binding]; other site
487521001569	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521001570	DNA binding site [nucleotide binding]
487521001571	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521001572	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521001573	dimerization interface [polypeptide binding]; other site
487521001574	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521001575	dimer interface [polypeptide binding]; other site
487521001576	phosphorylation site [posttranslational modification]
487521001577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521001578	ATP binding site [chemical binding]; other site
487521001579	Mg2+ binding site [ion binding]; other site
487521001580	G-X-G motif; other site
487521001581	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
487521001582	nucleotide binding site/active site [active]
487521001583	HIT family signature motif; other site
487521001584	catalytic residue [active]
487521001585	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
487521001586	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
487521001587	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
487521001588	NAD binding site [chemical binding]; other site
487521001589	catalytic Zn binding site [ion binding]; other site
487521001590	substrate binding site [chemical binding]; other site
487521001591	structural Zn binding site [ion binding]; other site
487521001592	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
487521001593	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
487521001594	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521001595	Cytochrome P450; Region: p450; cl12078
487521001596	short chain dehydrogenase; Provisional; Region: PRK07775
487521001597	classical (c) SDRs; Region: SDR_c; cd05233
487521001598	NAD(P) binding site [chemical binding]; other site
487521001599	active site
487521001600	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521001601	Cytochrome P450; Region: p450; cl12078
487521001602	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001603	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
487521001604	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
487521001605	NAD binding site [chemical binding]; other site
487521001606	catalytic residues [active]
487521001607	short chain dehydrogenase; Provisional; Region: PRK07774
487521001608	classical (c) SDRs; Region: SDR_c; cd05233
487521001609	NAD(P) binding site [chemical binding]; other site
487521001610	active site
487521001611	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
487521001612	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487521001613	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
487521001614	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
487521001615	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521001616	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521001617	active site
487521001618	catalytic tetrad [active]
487521001619	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521001620	MarR family; Region: MarR; pfam01047
487521001621	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
487521001622	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
487521001623	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
487521001624	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
487521001625	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
487521001626	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
487521001627	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
487521001628	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
487521001629	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
487521001630	adenylosuccinate lyase; Region: purB; TIGR00928
487521001631	tetramer interface [polypeptide binding]; other site
487521001632	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521001633	Cytochrome P450; Region: p450; cl12078
487521001634	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
487521001635	gating phenylalanine in ion channel; other site
487521001636	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
487521001637	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
487521001638	ATP binding site [chemical binding]; other site
487521001639	active site
487521001640	substrate binding site [chemical binding]; other site
487521001641	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
487521001642	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521001643	Major Facilitator Superfamily; Region: MFS_1; pfam07690
487521001644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521001645	putative substrate translocation pore; other site
487521001646	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521001647	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
487521001648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521001649	putative substrate translocation pore; other site
487521001650	Predicted deacetylase [General function prediction only]; Region: COG3233
487521001651	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
487521001652	putative active site [active]
487521001653	putative Zn binding site [ion binding]; other site
487521001654	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
487521001655	FAD binding domain; Region: FAD_binding_2; pfam00890
487521001656	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487521001657	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
487521001658	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
487521001659	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
487521001660	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
487521001661	putative active site [active]
487521001662	catalytic triad [active]
487521001663	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521001664	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521001665	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
487521001666	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
487521001667	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521001668	putative acyl-acceptor binding pocket; other site
487521001669	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521001670	extended (e) SDRs; Region: SDR_e; cd08946
487521001671	NAD(P) binding site [chemical binding]; other site
487521001672	active site
487521001673	substrate binding site [chemical binding]; other site
487521001674	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
487521001675	Cupin domain; Region: Cupin_2; cl17218
487521001676	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
487521001677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521001678	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487521001679	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
487521001680	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521001681	motif II; other site
487521001682	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
487521001683	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
487521001684	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521001685	Domain of unknown function (DUF427); Region: DUF427; cl00998
487521001686	Domain of unknown function (DUF427); Region: DUF427; cl00998
487521001687	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
487521001688	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
487521001689	putative NAD(P) binding site [chemical binding]; other site
487521001690	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001691	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001693	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521001694	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521001695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
487521001696	MOSC domain; Region: MOSC; pfam03473
487521001697	3-alpha domain; Region: 3-alpha; pfam03475
487521001698	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
487521001699	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
487521001700	FAD binding pocket [chemical binding]; other site
487521001701	FAD binding motif [chemical binding]; other site
487521001702	phosphate binding motif [ion binding]; other site
487521001703	beta-alpha-beta structure motif; other site
487521001704	NAD binding pocket [chemical binding]; other site
487521001705	Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804
487521001706	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
487521001707	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
487521001708	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
487521001709	active site
487521001710	metal binding site [ion binding]; metal-binding site
487521001711	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001712	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001713	Ecdysteroid kinase; Region: EcKinase; cl17738
487521001714	Phosphotransferase enzyme family; Region: APH; pfam01636
487521001715	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
487521001716	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
487521001717	dimerization interface [polypeptide binding]; other site
487521001718	ATP binding site [chemical binding]; other site
487521001719	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
487521001720	dimerization interface [polypeptide binding]; other site
487521001721	ATP binding site [chemical binding]; other site
487521001722	CAAX protease self-immunity; Region: Abi; pfam02517
487521001723	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521001724	mce related protein; Region: MCE; pfam02470
487521001725	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521001726	amidophosphoribosyltransferase; Provisional; Region: PRK07847
487521001727	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
487521001728	active site
487521001729	tetramer interface [polypeptide binding]; other site
487521001730	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521001731	active site
487521001732	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
487521001733	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
487521001734	dimerization interface [polypeptide binding]; other site
487521001735	putative ATP binding site [chemical binding]; other site
487521001736	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
487521001737	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
487521001738	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
487521001739	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
487521001740	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
487521001741	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
487521001742	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521001743	catalytic residue [active]
487521001744	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
487521001745	heme-binding site [chemical binding]; other site
487521001746	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
487521001747	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
487521001748	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
487521001749	active site residue [active]
487521001750	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
487521001751	active site residue [active]
487521001752	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
487521001753	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
487521001754	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487521001755	catalytic residues [active]
487521001756	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
487521001757	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521001758	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521001759	DNA binding site [nucleotide binding]
487521001760	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
487521001761	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521001762	Coenzyme A binding pocket [chemical binding]; other site
487521001763	PBP superfamily domain; Region: PBP_like_2; cl17296
487521001764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521001765	dimer interface [polypeptide binding]; other site
487521001766	conserved gate region; other site
487521001767	putative PBP binding loops; other site
487521001768	ABC-ATPase subunit interface; other site
487521001769	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
487521001770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521001771	dimer interface [polypeptide binding]; other site
487521001772	conserved gate region; other site
487521001773	putative PBP binding loops; other site
487521001774	ABC-ATPase subunit interface; other site
487521001775	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
487521001776	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
487521001777	Walker A/P-loop; other site
487521001778	ATP binding site [chemical binding]; other site
487521001779	Q-loop/lid; other site
487521001780	ABC transporter signature motif; other site
487521001781	Walker B; other site
487521001782	D-loop; other site
487521001783	H-loop/switch region; other site
487521001784	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
487521001785	PhoU domain; Region: PhoU; pfam01895
487521001786	PhoU domain; Region: PhoU; pfam01895
487521001787	cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350
487521001788	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
487521001789	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
487521001790	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
487521001791	FMN binding site [chemical binding]; other site
487521001792	active site
487521001793	catalytic residues [active]
487521001794	substrate binding site [chemical binding]; other site
487521001795	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
487521001796	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
487521001797	homodimer interface [polypeptide binding]; other site
487521001798	putative substrate binding pocket [chemical binding]; other site
487521001799	diiron center [ion binding]; other site
487521001800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
487521001801	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521001802	dimerization interface [polypeptide binding]; other site
487521001803	putative DNA binding site [nucleotide binding]; other site
487521001804	putative Zn2+ binding site [ion binding]; other site
487521001805	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
487521001806	nucleoside/Zn binding site; other site
487521001807	dimer interface [polypeptide binding]; other site
487521001808	catalytic motif [active]
487521001809	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521001810	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521001811	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
487521001812	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521001813	active site
487521001814	DNA binding site [nucleotide binding]
487521001815	Int/Topo IB signature motif; other site
487521001816	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
487521001817	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
487521001818	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521001819	DNA-binding site [nucleotide binding]; DNA binding site
487521001820	UTRA domain; Region: UTRA; pfam07702
487521001821	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
487521001822	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521001823	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521001824	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
487521001825	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
487521001826	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001827	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001828	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521001829	classical (c) SDRs; Region: SDR_c; cd05233
487521001830	NAD(P) binding site [chemical binding]; other site
487521001831	active site
487521001832	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001833	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001834	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521001835	Cytochrome P450; Region: p450; cl12078
487521001836	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
487521001837	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521001838	DNA-binding site [nucleotide binding]; DNA binding site
487521001839	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521001840	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521001841	homodimer interface [polypeptide binding]; other site
487521001842	catalytic residue [active]
487521001843	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521001844	Leucine carboxyl methyltransferase; Region: LCM; cl01306
487521001845	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
487521001846	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521001847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521001848	S-adenosylmethionine binding site [chemical binding]; other site
487521001849	short chain dehydrogenase; Provisional; Region: PRK07890
487521001850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001851	NAD(P) binding site [chemical binding]; other site
487521001852	active site
487521001853	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
487521001854	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
487521001855	B12 binding site [chemical binding]; other site
487521001856	cobalt ligand [ion binding]; other site
487521001857	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
487521001858	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521001859	putative CoA-transferase; Provisional; Region: PRK11430
487521001860	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521001861	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
487521001862	SnoaL-like domain; Region: SnoaL_3; pfam13474
487521001863	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521001864	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521001865	catalytic loop [active]
487521001866	iron binding site [ion binding]; other site
487521001867	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521001868	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521001869	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521001870	acyl-activating enzyme (AAE) consensus motif; other site
487521001871	acyl-activating enzyme (AAE) consensus motif; other site
487521001872	AMP binding site [chemical binding]; other site
487521001873	active site
487521001874	CoA binding site [chemical binding]; other site
487521001875	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001876	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001877	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521001878	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521001879	active site
487521001880	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521001881	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521001882	substrate binding site [chemical binding]; other site
487521001883	oxyanion hole (OAH) forming residues; other site
487521001884	trimer interface [polypeptide binding]; other site
487521001885	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
487521001886	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382
487521001887	putative acyltransferase; Provisional; Region: PRK05790
487521001888	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521001889	dimer interface [polypeptide binding]; other site
487521001890	active site
487521001891	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
487521001892	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
487521001893	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
487521001894	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
487521001895	TPP-binding site [chemical binding]; other site
487521001896	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521001897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521001898	active site
487521001899	phosphorylation site [posttranslational modification]
487521001900	intermolecular recognition site; other site
487521001901	dimerization interface [polypeptide binding]; other site
487521001902	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521001903	DNA binding residues [nucleotide binding]
487521001904	dimerization interface [polypeptide binding]; other site
487521001905	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
487521001906	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521001907	ATP binding site [chemical binding]; other site
487521001908	Mg2+ binding site [ion binding]; other site
487521001909	G-X-G motif; other site
487521001910	Methyltransferase domain; Region: Methyltransf_11; pfam08241
487521001911	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
487521001912	conserved cys residue [active]
487521001913	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
487521001914	Predicted oxidoreductase [General function prediction only]; Region: COG3573
487521001915	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521001916	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
487521001917	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521001918	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521001919	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
487521001920	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521001921	3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370
487521001922	active site
487521001923	metal binding site [ion binding]; metal-binding site
487521001924	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
487521001925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521001926	Predicted oxidoreductase [General function prediction only]; Region: COG3573
487521001927	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
487521001928	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
487521001929	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001930	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521001931	NAD(P) binding site [chemical binding]; other site
487521001932	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
487521001933	active site
487521001934	Putative cyclase; Region: Cyclase; pfam04199
487521001935	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521001936	TAP-like protein; Region: Abhydrolase_4; pfam08386
487521001937	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
487521001938	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
487521001939	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
487521001940	Multicopper oxidase; Region: Cu-oxidase; pfam00394
487521001941	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
487521001942	short chain dehydrogenase; Provisional; Region: PRK06500
487521001943	classical (c) SDRs; Region: SDR_c; cd05233
487521001944	NAD(P) binding site [chemical binding]; other site
487521001945	active site
487521001946	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
487521001947	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001948	NAD(P) binding site [chemical binding]; other site
487521001949	active site
487521001950	AAA ATPase domain; Region: AAA_16; pfam13191
487521001951	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521001952	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521001953	DNA binding residues [nucleotide binding]
487521001954	dimerization interface [polypeptide binding]; other site
487521001955	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
487521001956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001957	NAD(P) binding site [chemical binding]; other site
487521001958	active site
487521001959	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487521001960	active site
487521001961	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
487521001962	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
487521001963	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
487521001964	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521001965	putative ADP-binding pocket [chemical binding]; other site
487521001966	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
487521001967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521001968	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521001969	Cytochrome P450; Region: p450; cl12078
487521001970	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521001971	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521001972	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487521001973	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
487521001974	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
487521001975	active site
487521001976	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487521001977	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
487521001978	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
487521001979	active site
487521001980	enoyl-CoA hydratase; Provisional; Region: PRK12478
487521001981	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521001982	substrate binding site [chemical binding]; other site
487521001983	oxyanion hole (OAH) forming residues; other site
487521001984	trimer interface [polypeptide binding]; other site
487521001985	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521001986	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521001987	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521001988	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521001989	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
487521001990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521001991	NAD(P) binding site [chemical binding]; other site
487521001992	active site
487521001993	short chain dehydrogenase; Provisional; Region: PRK05876
487521001994	classical (c) SDRs; Region: SDR_c; cd05233
487521001995	NAD(P) binding site [chemical binding]; other site
487521001996	active site
487521001997	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521001998	classical (c) SDRs; Region: SDR_c; cd05233
487521001999	NAD(P) binding site [chemical binding]; other site
487521002000	active site
487521002001	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002002	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002003	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002004	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002005	active site
487521002006	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002007	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002008	active site
487521002009	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002010	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002011	active site
487521002012	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521002013	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
487521002014	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521002015	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
487521002016	active site
487521002017	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521002018	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521002019	[2Fe-2S] cluster binding site [ion binding]; other site
487521002020	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
487521002021	alpha subunit interface [polypeptide binding]; other site
487521002022	active site
487521002023	substrate binding site [chemical binding]; other site
487521002024	Fe binding site [ion binding]; other site
487521002025	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521002026	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521002027	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521002028	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002029	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002030	active site
487521002031	enoyl-CoA hydratase; Provisional; Region: PRK06688
487521002032	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002033	substrate binding site [chemical binding]; other site
487521002034	oxyanion hole (OAH) forming residues; other site
487521002035	trimer interface [polypeptide binding]; other site
487521002036	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
487521002037	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521002038	dimer interface [polypeptide binding]; other site
487521002039	active site
487521002040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002041	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521002042	Cytochrome P450; Region: p450; cl12078
487521002043	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
487521002044	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
487521002045	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
487521002046	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
487521002047	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521002048	Cytochrome P450; Region: p450; cl12078
487521002049	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
487521002050	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487521002051	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487521002052	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
487521002053	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521002054	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521002055	lipid-transfer protein; Provisional; Region: PRK07855
487521002056	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521002057	active site
487521002058	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521002059	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521002060	NAD(P) binding site [chemical binding]; other site
487521002061	active site
487521002062	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
487521002063	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521002064	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521002065	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002066	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002067	active site
487521002068	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
487521002069	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
487521002070	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521002071	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
487521002072	iron-sulfur cluster [ion binding]; other site
487521002073	[2Fe-2S] cluster binding site [ion binding]; other site
487521002074	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521002075	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521002076	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
487521002077	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487521002078	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
487521002079	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521002080	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
487521002081	NAD(P) binding site [chemical binding]; other site
487521002082	catalytic residues [active]
487521002083	catalytic residues [active]
487521002084	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002085	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002086	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
487521002087	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002088	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
487521002089	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
487521002090	putative catalytic cysteine [active]
487521002091	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
487521002092	FMN binding site [chemical binding]; other site
487521002093	dimer interface [polypeptide binding]; other site
487521002094	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
487521002095	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521002096	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002097	active site
487521002098	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002099	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002100	active site
487521002101	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521002102	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521002103	Integrase core domain; Region: rve; pfam00665
487521002104	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521002105	Cytochrome P450; Region: p450; cl12078
487521002106	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
487521002107	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521002108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521002109	NAD(P) binding site [chemical binding]; other site
487521002110	active site
487521002111	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
487521002112	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
487521002113	NAD binding site [chemical binding]; other site
487521002114	catalytic residues [active]
487521002115	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521002116	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521002117	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521002118	Permease; Region: Permease; pfam02405
487521002119	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521002120	Permease; Region: Permease; pfam02405
487521002121	mce related protein; Region: MCE; pfam02470
487521002122	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521002123	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521002124	mce related protein; Region: MCE; pfam02470
487521002125	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521002126	mce related protein; Region: MCE; pfam02470
487521002127	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521002128	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521002129	mce related protein; Region: MCE; pfam02470
487521002130	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521002131	mce related protein; Region: MCE; pfam02470
487521002132	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521002133	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521002134	mce related protein; Region: MCE; pfam02470
487521002135	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002136	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002137	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
487521002138	Subunit I/III interface [polypeptide binding]; other site
487521002139	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521002140	Cytochrome P450; Region: p450; cl12078
487521002141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002143	enoyl-CoA hydratase; Provisional; Region: PRK06688
487521002144	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002145	substrate binding site [chemical binding]; other site
487521002146	oxyanion hole (OAH) forming residues; other site
487521002147	trimer interface [polypeptide binding]; other site
487521002148	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
487521002149	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521002150	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
487521002151	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521002152	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
487521002153	acyl-activating enzyme (AAE) consensus motif; other site
487521002154	acyl-activating enzyme (AAE) consensus motif; other site
487521002155	putative AMP binding site [chemical binding]; other site
487521002156	putative active site [active]
487521002157	putative CoA binding site [chemical binding]; other site
487521002158	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
487521002159	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
487521002160	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
487521002161	dimer interface [polypeptide binding]; other site
487521002162	PYR/PP interface [polypeptide binding]; other site
487521002163	TPP binding site [chemical binding]; other site
487521002164	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521002165	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
487521002166	TPP-binding site [chemical binding]; other site
487521002167	dimer interface [polypeptide binding]; other site
487521002168	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
487521002169	putative hydrophobic ligand binding site [chemical binding]; other site
487521002170	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521002171	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521002172	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
487521002173	putative hydrophobic ligand binding site [chemical binding]; other site
487521002174	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
487521002175	putative hydrophobic ligand binding site [chemical binding]; other site
487521002176	aminotransferase; Validated; Region: PRK07777
487521002177	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521002178	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521002179	homodimer interface [polypeptide binding]; other site
487521002180	catalytic residue [active]
487521002181	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
487521002182	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521002183	dimer interface [polypeptide binding]; other site
487521002184	active site
487521002185	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521002186	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002187	substrate binding site [chemical binding]; other site
487521002188	oxyanion hole (OAH) forming residues; other site
487521002189	trimer interface [polypeptide binding]; other site
487521002190	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
487521002191	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
487521002192	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
487521002193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521002194	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
487521002195	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
487521002196	hypothetical protein; Provisional; Region: PRK07588
487521002197	hypothetical protein; Provisional; Region: PRK07236
487521002198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002200	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521002201	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
487521002202	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
487521002203	Cupin; Region: Cupin_6; pfam12852
487521002204	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
487521002205	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521002206	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
487521002207	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521002208	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521002209	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
487521002210	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521002211	active site
487521002212	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
487521002213	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
487521002214	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
487521002215	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521002216	ATP binding site [chemical binding]; other site
487521002217	putative Mg++ binding site [ion binding]; other site
487521002218	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521002219	nucleotide binding region [chemical binding]; other site
487521002220	ATP-binding site [chemical binding]; other site
487521002221	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
487521002222	WYL domain; Region: WYL; pfam13280
487521002223	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
487521002224	trimer interface [polypeptide binding]; other site
487521002225	dimer interface [polypeptide binding]; other site
487521002226	putative active site [active]
487521002227	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
487521002228	MPT binding site; other site
487521002229	trimer interface [polypeptide binding]; other site
487521002230	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
487521002231	MoaE homodimer interface [polypeptide binding]; other site
487521002232	MoaD interaction [polypeptide binding]; other site
487521002233	active site residues [active]
487521002234	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
487521002235	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
487521002236	MoaE interaction surface [polypeptide binding]; other site
487521002237	MoeB interaction surface [polypeptide binding]; other site
487521002238	thiocarboxylated glycine; other site
487521002239	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
487521002240	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521002241	FeS/SAM binding site; other site
487521002242	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
487521002243	hypothetical protein; Provisional; Region: PRK11770
487521002244	Domain of unknown function (DUF307); Region: DUF307; pfam03733
487521002245	Domain of unknown function (DUF307); Region: DUF307; pfam03733
487521002246	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
487521002247	DNA-binding site [nucleotide binding]; DNA binding site
487521002248	RNA-binding motif; other site
487521002249	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002250	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002251	active site
487521002252	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
487521002253	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
487521002254	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
487521002255	putative dimer interface [polypeptide binding]; other site
487521002256	N-terminal domain interface [polypeptide binding]; other site
487521002257	putative substrate binding pocket (H-site) [chemical binding]; other site
487521002258	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
487521002259	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
487521002260	H+ Antiporter protein; Region: 2A0121; TIGR00900
487521002261	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
487521002262	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521002263	hydrophobic ligand binding site; other site
487521002264	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521002265	MarR family; Region: MarR; pfam01047
487521002266	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
487521002267	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
487521002268	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
487521002269	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
487521002270	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521002271	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521002272	catalytic residue [active]
487521002273	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
487521002274	Ferredoxin [Energy production and conversion]; Region: COG1146
487521002275	4Fe-4S binding domain; Region: Fer4; pfam00037
487521002276	ferredoxin-NADP+ reductase; Region: PLN02852
487521002277	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521002278	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
487521002279	putative dimer interface [polypeptide binding]; other site
487521002280	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521002281	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
487521002282	dimer interface [polypeptide binding]; other site
487521002283	Citrate synthase; Region: Citrate_synt; pfam00285
487521002284	active site
487521002285	citrylCoA binding site [chemical binding]; other site
487521002286	oxalacetate/citrate binding site [chemical binding]; other site
487521002287	coenzyme A binding site [chemical binding]; other site
487521002288	catalytic triad [active]
487521002289	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
487521002290	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
487521002291	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
487521002292	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
487521002293	active site
487521002294	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
487521002295	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
487521002296	dimer interface [polypeptide binding]; other site
487521002297	active site
487521002298	citrylCoA binding site [chemical binding]; other site
487521002299	NADH binding [chemical binding]; other site
487521002300	cationic pore residues; other site
487521002301	oxalacetate/citrate binding site [chemical binding]; other site
487521002302	coenzyme A binding site [chemical binding]; other site
487521002303	catalytic triad [active]
487521002304	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
487521002305	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521002306	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
487521002307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521002308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521002309	dimer interface [polypeptide binding]; other site
487521002310	phosphorylation site [posttranslational modification]
487521002311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521002312	ATP binding site [chemical binding]; other site
487521002313	Mg2+ binding site [ion binding]; other site
487521002314	G-X-G motif; other site
487521002315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521002316	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521002317	active site
487521002318	phosphorylation site [posttranslational modification]
487521002319	intermolecular recognition site; other site
487521002320	dimerization interface [polypeptide binding]; other site
487521002321	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521002322	DNA binding site [nucleotide binding]
487521002323	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
487521002324	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
487521002325	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521002326	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521002327	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002328	substrate binding site [chemical binding]; other site
487521002329	oxyanion hole (OAH) forming residues; other site
487521002330	trimer interface [polypeptide binding]; other site
487521002331	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487521002332	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
487521002333	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521002334	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521002335	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
487521002336	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
487521002337	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521002338	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521002339	motif II; other site
487521002340	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
487521002341	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521002342	hydrophobic ligand binding site; other site
487521002343	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
487521002344	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521002345	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
487521002346	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521002347	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521002348	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521002349	active site
487521002350	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
487521002351	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
487521002352	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
487521002353	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521002354	active site
487521002355	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
487521002356	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521002357	PPE family; Region: PPE; pfam00823
487521002358	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521002359	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521002360	PPE family; Region: PPE; pfam00823
487521002361	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
487521002362	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521002363	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
487521002364	dimerization interface [polypeptide binding]; other site
487521002365	putative catalytic residue [active]
487521002366	Protein of unknown function (DUF867); Region: DUF867; pfam05908
487521002367	manganese transport protein MntH; Reviewed; Region: PRK00701
487521002368	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
487521002369	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521002370	short chain dehydrogenase; Provisional; Region: PRK07814
487521002371	classical (c) SDRs; Region: SDR_c; cd05233
487521002372	NAD(P) binding site [chemical binding]; other site
487521002373	active site
487521002374	PBP superfamily domain; Region: PBP_like_2; cl17296
487521002375	PBP superfamily domain; Region: PBP_like_2; cl17296
487521002376	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
487521002377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521002378	dimer interface [polypeptide binding]; other site
487521002379	conserved gate region; other site
487521002380	putative PBP binding loops; other site
487521002381	ABC-ATPase subunit interface; other site
487521002382	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
487521002383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521002384	dimer interface [polypeptide binding]; other site
487521002385	conserved gate region; other site
487521002386	putative PBP binding loops; other site
487521002387	ABC-ATPase subunit interface; other site
487521002388	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
487521002389	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
487521002390	putative DNA binding site [nucleotide binding]; other site
487521002391	putative homodimer interface [polypeptide binding]; other site
487521002392	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
487521002393	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
487521002394	putative substrate binding site [chemical binding]; other site
487521002395	putative ATP binding site [chemical binding]; other site
487521002396	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
487521002397	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
487521002398	nucleotide binding site [chemical binding]; other site
487521002399	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
487521002400	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
487521002401	active site
487521002402	DNA binding site [nucleotide binding]
487521002403	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
487521002404	DNA binding site [nucleotide binding]
487521002405	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
487521002406	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
487521002407	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521002408	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521002409	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521002410	enoyl-CoA hydratase; Provisional; Region: PRK08260
487521002411	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002412	substrate binding site [chemical binding]; other site
487521002413	oxyanion hole (OAH) forming residues; other site
487521002414	trimer interface [polypeptide binding]; other site
487521002415	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521002416	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521002417	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521002418	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521002419	anti sigma factor interaction site; other site
487521002420	regulatory phosphorylation site [posttranslational modification]; other site
487521002421	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521002422	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
487521002423	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
487521002424	active site
487521002425	SAM binding site [chemical binding]; other site
487521002426	homodimer interface [polypeptide binding]; other site
487521002427	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
487521002428	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
487521002429	putative DNA binding site [nucleotide binding]; other site
487521002430	catalytic residue [active]
487521002431	putative H2TH interface [polypeptide binding]; other site
487521002432	putative catalytic residues [active]
487521002433	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
487521002434	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
487521002435	short chain dehydrogenase; Provisional; Region: PRK08251
487521002436	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
487521002437	putative NAD(P) binding site [chemical binding]; other site
487521002438	active site
487521002439	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
487521002440	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
487521002441	active site
487521002442	dimer interface [polypeptide binding]; other site
487521002443	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
487521002444	dimer interface [polypeptide binding]; other site
487521002445	active site
487521002446	Chorismate mutase type II; Region: CM_2; cl00693
487521002447	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
487521002448	Part of AAA domain; Region: AAA_19; pfam13245
487521002449	Family description; Region: UvrD_C_2; pfam13538
487521002450	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
487521002451	Peptidase family M23; Region: Peptidase_M23; pfam01551
487521002452	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
487521002453	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
487521002454	CoA-ligase; Region: Ligase_CoA; pfam00549
487521002455	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
487521002456	CoA binding domain; Region: CoA_binding; smart00881
487521002457	CoA-ligase; Region: Ligase_CoA; pfam00549
487521002458	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
487521002459	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521002460	Omptin family; Region: Omptin; cl01886
487521002461	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521002462	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521002463	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
487521002464	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
487521002465	active site
487521002466	substrate binding site [chemical binding]; other site
487521002467	cosubstrate binding site; other site
487521002468	catalytic site [active]
487521002469	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
487521002470	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
487521002471	purine monophosphate binding site [chemical binding]; other site
487521002472	dimer interface [polypeptide binding]; other site
487521002473	putative catalytic residues [active]
487521002474	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
487521002475	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
487521002476	LGFP repeat; Region: LGFP; pfam08310
487521002477	LGFP repeat; Region: LGFP; pfam08310
487521002478	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
487521002479	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
487521002480	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
487521002481	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
487521002482	metal ion-dependent adhesion site (MIDAS); other site
487521002483	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521002484	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521002485	active site
487521002486	catalytic tetrad [active]
487521002487	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
487521002488	enoyl-CoA hydratase; Provisional; Region: PRK07827
487521002489	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002490	substrate binding site [chemical binding]; other site
487521002491	oxyanion hole (OAH) forming residues; other site
487521002492	trimer interface [polypeptide binding]; other site
487521002493	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002494	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521002495	active site
487521002496	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
487521002497	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487521002498	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521002499	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
487521002500	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
487521002501	carboxyltransferase (CT) interaction site; other site
487521002502	biotinylation site [posttranslational modification]; other site
487521002503	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
487521002504	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521002505	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521002506	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521002507	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521002508	active site
487521002509	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
487521002510	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
487521002511	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521002512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521002513	active site
487521002514	phosphorylation site [posttranslational modification]
487521002515	intermolecular recognition site; other site
487521002516	dimerization interface [polypeptide binding]; other site
487521002517	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521002518	DNA binding site [nucleotide binding]
487521002519	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521002520	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521002521	dimerization interface [polypeptide binding]; other site
487521002522	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521002523	dimer interface [polypeptide binding]; other site
487521002524	phosphorylation site [posttranslational modification]
487521002525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521002526	ATP binding site [chemical binding]; other site
487521002527	Mg2+ binding site [ion binding]; other site
487521002528	G-X-G motif; other site
487521002529	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
487521002530	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
487521002531	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
487521002532	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
487521002533	MPT binding site; other site
487521002534	trimer interface [polypeptide binding]; other site
487521002535	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
487521002536	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
487521002537	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
487521002538	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
487521002539	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
487521002540	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
487521002541	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
487521002542	active site
487521002543	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
487521002544	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
487521002545	dimer interface [polypeptide binding]; other site
487521002546	putative functional site; other site
487521002547	putative MPT binding site; other site
487521002548	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
487521002549	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
487521002550	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521002551	MarR family; Region: MarR_2; pfam12802
487521002552	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
487521002553	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
487521002554	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521002555	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521002556	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
487521002557	Transcriptional regulators [Transcription]; Region: FadR; COG2186
487521002558	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521002559	DNA-binding site [nucleotide binding]; DNA binding site
487521002560	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
487521002561	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521002562	Cytochrome P450; Region: p450; cl12078
487521002563	Predicted acyl esterases [General function prediction only]; Region: COG2936
487521002564	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
487521002565	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
487521002566	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
487521002567	metal binding site [ion binding]; metal-binding site
487521002568	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
487521002569	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
487521002570	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
487521002571	dimer interface [polypeptide binding]; other site
487521002572	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
487521002573	active site
487521002574	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
487521002575	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521002576	active site
487521002577	motif I; other site
487521002578	motif II; other site
487521002579	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
487521002580	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
487521002581	ligand binding site [chemical binding]; other site
487521002582	flexible hinge region; other site
487521002583	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487521002584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521002585	Coenzyme A binding pocket [chemical binding]; other site
487521002586	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
487521002587	Amidinotransferase; Region: Amidinotransf; cl12043
487521002588	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
487521002589	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
487521002590	Predicted methyltransferases [General function prediction only]; Region: COG0313
487521002591	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
487521002592	putative SAM binding site [chemical binding]; other site
487521002593	putative homodimer interface [polypeptide binding]; other site
487521002594	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
487521002595	chorismate binding enzyme; Region: Chorismate_bind; cl10555
487521002596	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
487521002597	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521002598	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
487521002599	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
487521002600	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521002601	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521002602	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
487521002603	GAF domain; Region: GAF; pfam01590
487521002604	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
487521002605	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
487521002606	metal binding site [ion binding]; metal-binding site
487521002607	active site
487521002608	I-site; other site
487521002609	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
487521002610	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
487521002611	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
487521002612	Chain length determinant protein; Region: Wzz; pfam02706
487521002613	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
487521002614	O-Antigen ligase; Region: Wzy_C; cl04850
487521002615	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521002616	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521002617	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521002618	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521002619	active site
487521002620	catalytic tetrad [active]
487521002621	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
487521002622	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
487521002623	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
487521002624	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
487521002625	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
487521002626	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
487521002627	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
487521002628	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
487521002629	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521002630	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
487521002631	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487521002632	active site
487521002633	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487521002634	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521002635	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521002636	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
487521002637	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
487521002638	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
487521002639	Bacterial sugar transferase; Region: Bac_transf; pfam02397
487521002640	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
487521002641	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521002642	PPE family; Region: PPE; pfam00823
487521002643	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521002644	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002645	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002646	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002647	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002648	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
487521002649	PAS domain; Region: PAS_9; pfam13426
487521002650	putative active site [active]
487521002651	heme pocket [chemical binding]; other site
487521002652	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002653	WHG domain; Region: WHG; pfam13305
487521002654	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
487521002655	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
487521002656	active site
487521002657	HIGH motif; other site
487521002658	KMSKS motif; other site
487521002659	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
487521002660	tRNA binding surface [nucleotide binding]; other site
487521002661	anticodon binding site; other site
487521002662	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
487521002663	active site
487521002664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
487521002665	Domain of unknown function (DUF348); Region: DUF348; pfam03990
487521002666	Domain of unknown function (DUF348); Region: DUF348; pfam03990
487521002667	G5 domain; Region: G5; pfam07501
487521002668	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
487521002669	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
487521002670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521002671	S-adenosylmethionine binding site [chemical binding]; other site
487521002672	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
487521002673	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
487521002674	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521002675	acyl-activating enzyme (AAE) consensus motif; other site
487521002676	AMP binding site [chemical binding]; other site
487521002677	active site
487521002678	CoA binding site [chemical binding]; other site
487521002679	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
487521002680	putative active site [active]
487521002681	catalytic residue [active]
487521002682	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
487521002683	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
487521002684	5S rRNA interface [nucleotide binding]; other site
487521002685	CTC domain interface [polypeptide binding]; other site
487521002686	L16 interface [polypeptide binding]; other site
487521002687	short chain dehydrogenase; Provisional; Region: PRK06197
487521002688	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
487521002689	putative NAD(P) binding site [chemical binding]; other site
487521002690	active site
487521002691	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521002692	Cytochrome P450; Region: p450; cl12078
487521002693	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521002694	cyclase homology domain; Region: CHD; cd07302
487521002695	nucleotidyl binding site; other site
487521002696	metal binding site [ion binding]; metal-binding site
487521002697	dimer interface [polypeptide binding]; other site
487521002698	Predicted ATPase [General function prediction only]; Region: COG3903
487521002699	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521002700	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521002701	DNA binding residues [nucleotide binding]
487521002702	dimerization interface [polypeptide binding]; other site
487521002703	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
487521002704	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
487521002705	ArsC family; Region: ArsC; pfam03960
487521002706	catalytic residues [active]
487521002707	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
487521002708	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
487521002709	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521002710	active site
487521002711	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
487521002712	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
487521002713	Substrate binding site; other site
487521002714	Mg++ binding site; other site
487521002715	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
487521002716	active site
487521002717	substrate binding site [chemical binding]; other site
487521002718	CoA binding site [chemical binding]; other site
487521002719	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002720	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002721	diaminopimelate decarboxylase; Region: lysA; TIGR01048
487521002722	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
487521002723	active site
487521002724	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487521002725	substrate binding site [chemical binding]; other site
487521002726	catalytic residues [active]
487521002727	dimer interface [polypeptide binding]; other site
487521002728	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
487521002729	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
487521002730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521002731	ATP binding site [chemical binding]; other site
487521002732	putative Mg++ binding site [ion binding]; other site
487521002733	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521002734	nucleotide binding region [chemical binding]; other site
487521002735	ATP-binding site [chemical binding]; other site
487521002736	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
487521002737	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
487521002738	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
487521002739	homodimer interface [polypeptide binding]; other site
487521002740	metal binding site [ion binding]; metal-binding site
487521002741	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
487521002742	N-acetyl-D-glucosamine binding site [chemical binding]; other site
487521002743	enolase; Provisional; Region: eno; PRK00077
487521002744	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
487521002745	dimer interface [polypeptide binding]; other site
487521002746	metal binding site [ion binding]; metal-binding site
487521002747	substrate binding pocket [chemical binding]; other site
487521002748	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
487521002749	Septum formation initiator; Region: DivIC; pfam04977
487521002750	Uncharacterized conserved protein [Function unknown]; Region: COG1507
487521002751	exopolyphosphatase; Region: exo_poly_only; TIGR03706
487521002752	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
487521002753	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
487521002754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521002755	active site
487521002756	phosphorylation site [posttranslational modification]
487521002757	intermolecular recognition site; other site
487521002758	dimerization interface [polypeptide binding]; other site
487521002759	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521002760	DNA binding site [nucleotide binding]
487521002761	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
487521002762	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
487521002763	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
487521002764	Ligand Binding Site [chemical binding]; other site
487521002765	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521002766	dimer interface [polypeptide binding]; other site
487521002767	phosphorylation site [posttranslational modification]
487521002768	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521002769	ATP binding site [chemical binding]; other site
487521002770	Mg2+ binding site [ion binding]; other site
487521002771	G-X-G motif; other site
487521002772	K+-transporting ATPase, c chain; Region: KdpC; cl00944
487521002773	K+-transporting ATPase, c chain; Region: KdpC; cl00944
487521002774	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
487521002775	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521002776	Soluble P-type ATPase [General function prediction only]; Region: COG4087
487521002777	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
487521002778	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521002779	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521002780	dimer interface [polypeptide binding]; other site
487521002781	phosphorylation site [posttranslational modification]
487521002782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521002783	ATP binding site [chemical binding]; other site
487521002784	Mg2+ binding site [ion binding]; other site
487521002785	G-X-G motif; other site
487521002786	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521002787	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521002788	active site
487521002789	phosphorylation site [posttranslational modification]
487521002790	intermolecular recognition site; other site
487521002791	dimerization interface [polypeptide binding]; other site
487521002792	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521002793	DNA binding site [nucleotide binding]
487521002794	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
487521002795	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
487521002796	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521002797	PPE family; Region: PPE; pfam00823
487521002798	PE family; Region: PE; pfam00934
487521002799	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521002800	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
487521002801	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521002802	active site
487521002803	DNA binding site [nucleotide binding]
487521002804	Int/Topo IB signature motif; other site
487521002805	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
487521002806	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
487521002807	catalytic residues [active]
487521002808	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
487521002809	AAA domain; Region: AAA_25; pfam13481
487521002810	Walker B motif; other site
487521002811	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
487521002812	polymerase nucleotide-binding site; other site
487521002813	DNA-binding residues [nucleotide binding]; DNA binding site
487521002814	nucleotide binding site [chemical binding]; other site
487521002815	primase nucleotide-binding site [nucleotide binding]; other site
487521002816	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
487521002817	Transposase; Region: HTH_Tnp_1; cl17663
487521002818	HTH-like domain; Region: HTH_21; pfam13276
487521002819	Integrase core domain; Region: rve; pfam00665
487521002820	Integrase core domain; Region: rve_3; cl15866
487521002821	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521002822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521002823	S-adenosylmethionine binding site [chemical binding]; other site
487521002824	Domain of unknown function (DUF427); Region: DUF427; cl00998
487521002825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
487521002826	Uncharacterized conserved protein [Function unknown]; Region: COG3391
487521002827	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521002828	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521002829	Integrase core domain; Region: rve; pfam00665
487521002830	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
487521002831	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
487521002832	dimer interface [polypeptide binding]; other site
487521002833	acyl-activating enzyme (AAE) consensus motif; other site
487521002834	putative active site [active]
487521002835	AMP binding site [chemical binding]; other site
487521002836	putative CoA binding site [chemical binding]; other site
487521002837	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521002838	hydrophobic ligand binding site; other site
487521002839	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
487521002840	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
487521002841	putative active site [active]
487521002842	putative dimer interface [polypeptide binding]; other site
487521002843	Patatin-like phospholipase; Region: Patatin; pfam01734
487521002844	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
487521002845	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
487521002846	active site
487521002847	nucleophile elbow; other site
487521002848	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
487521002849	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
487521002850	active site residue [active]
487521002851	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521002852	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521002853	Predicted membrane protein [Function unknown]; Region: COG4425
487521002854	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
487521002855	enoyl-CoA hydratase; Provisional; Region: PRK05862
487521002856	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002857	substrate binding site [chemical binding]; other site
487521002858	oxyanion hole (OAH) forming residues; other site
487521002859	trimer interface [polypeptide binding]; other site
487521002860	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
487521002861	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521002862	substrate binding site [chemical binding]; other site
487521002863	oxyanion hole (OAH) forming residues; other site
487521002864	trimer interface [polypeptide binding]; other site
487521002865	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
487521002866	Bax inhibitor 1 like; Region: BaxI_1; cl17691
487521002867	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521002868	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521002869	Integrase core domain; Region: rve; pfam00665
487521002870	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
487521002871	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521002872	dimer interface [polypeptide binding]; other site
487521002873	active site
487521002874	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
487521002875	active site
487521002876	catalytic triad [active]
487521002877	oxyanion hole [active]
487521002878	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521002879	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521002880	substrate binding pocket [chemical binding]; other site
487521002881	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
487521002882	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
487521002883	dimer interface [polypeptide binding]; other site
487521002884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521002885	catalytic residue [active]
487521002886	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
487521002887	RDD family; Region: RDD; pfam06271
487521002888	cystathionine gamma-synthase; Provisional; Region: PRK07811
487521002889	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
487521002890	homodimer interface [polypeptide binding]; other site
487521002891	substrate-cofactor binding pocket; other site
487521002892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521002893	catalytic residue [active]
487521002894	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
487521002895	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
487521002896	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
487521002897	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
487521002898	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
487521002899	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
487521002900	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
487521002901	catalytic residues [active]
487521002902	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
487521002903	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521002904	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
487521002905	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
487521002906	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
487521002907	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
487521002908	catalytic residue [active]
487521002909	putative FPP diphosphate  binding site; other site
487521002910	putative FPP binding hydrophobic cleft; other site
487521002911	dimer interface [polypeptide binding]; other site
487521002912	putative IPP diphosphate binding site; other site
487521002913	pantothenate kinase; Provisional; Region: PRK05439
487521002914	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
487521002915	ATP-binding site [chemical binding]; other site
487521002916	CoA-binding site [chemical binding]; other site
487521002917	Mg2+-binding site [ion binding]; other site
487521002918	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
487521002919	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
487521002920	dimer interface [polypeptide binding]; other site
487521002921	active site
487521002922	glycine-pyridoxal phosphate binding site [chemical binding]; other site
487521002923	folate binding site [chemical binding]; other site
487521002924	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
487521002925	dinuclear metal binding motif [ion binding]; other site
487521002926	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
487521002927	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
487521002928	putative active site [active]
487521002929	PhoH-like protein; Region: PhoH; pfam02562
487521002930	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
487521002931	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
487521002932	NodB motif; other site
487521002933	active site
487521002934	catalytic site [active]
487521002935	metal binding site [ion binding]; metal-binding site
487521002936	HAMP domain; Region: HAMP; pfam00672
487521002937	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
487521002938	cyclase homology domain; Region: CHD; cd07302
487521002939	nucleotidyl binding site; other site
487521002940	metal binding site [ion binding]; metal-binding site
487521002941	dimer interface [polypeptide binding]; other site
487521002942	fumarate hydratase; Reviewed; Region: fumC; PRK00485
487521002943	Class II fumarases; Region: Fumarase_classII; cd01362
487521002944	active site
487521002945	tetramer interface [polypeptide binding]; other site
487521002946	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
487521002947	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
487521002948	putative active site [active]
487521002949	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
487521002950	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
487521002951	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
487521002952	homodimer interface [polypeptide binding]; other site
487521002953	active site
487521002954	TDP-binding site; other site
487521002955	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521002956	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521002957	acyl-activating enzyme (AAE) consensus motif; other site
487521002958	AMP binding site [chemical binding]; other site
487521002959	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521002960	Condensation domain; Region: Condensation; pfam00668
487521002961	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521002962	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
487521002963	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521002964	substrate binding pocket [chemical binding]; other site
487521002965	catalytic triad [active]
487521002966	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
487521002967	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
487521002968	putative NAD(P) binding site [chemical binding]; other site
487521002969	active site
487521002970	putative substrate binding site [chemical binding]; other site
487521002971	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
487521002972	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
487521002973	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
487521002974	generic binding surface II; other site
487521002975	generic binding surface I; other site
487521002976	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
487521002977	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
487521002978	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
487521002979	Membrane protein of unknown function; Region: DUF360; cl00850
487521002980	GTP-binding protein YchF; Reviewed; Region: PRK09601
487521002981	YchF GTPase; Region: YchF; cd01900
487521002982	G1 box; other site
487521002983	GTP/Mg2+ binding site [chemical binding]; other site
487521002984	Switch I region; other site
487521002985	G2 box; other site
487521002986	Switch II region; other site
487521002987	G3 box; other site
487521002988	G4 box; other site
487521002989	G5 box; other site
487521002990	Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071
487521002991	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521002992	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
487521002993	putative active site [active]
487521002994	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
487521002995	putative dimer interface [polypeptide binding]; other site
487521002996	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521002997	ligand binding site [chemical binding]; other site
487521002998	Zn binding site [ion binding]; other site
487521002999	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521003000	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521003001	active site
487521003002	metal binding site [ion binding]; metal-binding site
487521003003	NlpC/P60 family; Region: NLPC_P60; cl17555
487521003004	Uncharacterized conserved protein [Function unknown]; Region: COG1359
487521003005	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521003006	cyclase homology domain; Region: CHD; cd07302
487521003007	nucleotidyl binding site; other site
487521003008	metal binding site [ion binding]; metal-binding site
487521003009	dimer interface [polypeptide binding]; other site
487521003010	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
487521003011	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
487521003012	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
487521003013	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
487521003014	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487521003015	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521003016	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521003017	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
487521003018	dimer interface [polypeptide binding]; other site
487521003019	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521003020	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521003021	pyruvate phosphate dikinase; Provisional; Region: PRK05878
487521003022	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
487521003023	Predicted membrane protein [Function unknown]; Region: COG2259
487521003024	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
487521003025	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521003026	hydroxyglutarate oxidase; Provisional; Region: PRK11728
487521003027	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
487521003028	TrkA-C domain; Region: TrkA_C; pfam02080
487521003029	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
487521003030	TrkA-N domain; Region: TrkA_N; pfam02254
487521003031	TrkA-C domain; Region: TrkA_C; pfam02080
487521003032	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
487521003033	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
487521003034	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
487521003035	THF binding site; other site
487521003036	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
487521003037	substrate binding site [chemical binding]; other site
487521003038	THF binding site; other site
487521003039	zinc-binding site [ion binding]; other site
487521003040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003041	NADH(P)-binding; Region: NAD_binding_10; pfam13460
487521003042	NAD(P) binding site [chemical binding]; other site
487521003043	active site
487521003044	short chain dehydrogenase; Provisional; Region: PRK12829
487521003045	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003046	NAD(P) binding site [chemical binding]; other site
487521003047	active site
487521003048	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003050	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003051	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003052	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
487521003053	FMN binding site [chemical binding]; other site
487521003054	dimer interface [polypeptide binding]; other site
487521003055	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003056	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521003057	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003058	active site
487521003059	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003060	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
487521003061	active site
487521003062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003063	short chain dehydrogenase; Provisional; Region: PRK07791
487521003064	NAD(P) binding site [chemical binding]; other site
487521003065	active site
487521003066	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
487521003067	metal ion-dependent adhesion site (MIDAS); other site
487521003068	MoxR-like ATPases [General function prediction only]; Region: COG0714
487521003069	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
487521003070	Walker A motif; other site
487521003071	ATP binding site [chemical binding]; other site
487521003072	Walker B motif; other site
487521003073	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
487521003074	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
487521003075	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
487521003076	ligand binding site [chemical binding]; other site
487521003077	short chain dehydrogenase; Provisional; Region: PRK06179
487521003078	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
487521003079	NADP binding site [chemical binding]; other site
487521003080	active site
487521003081	steroid binding site; other site
487521003082	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003083	Cytochrome P450; Region: p450; cl12078
487521003084	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
487521003085	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
487521003086	NAD binding site [chemical binding]; other site
487521003087	catalytic residues [active]
487521003088	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
487521003089	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521003090	dimer interface [polypeptide binding]; other site
487521003091	active site
487521003092	enoyl-CoA hydratase; Provisional; Region: PRK08252
487521003093	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003094	substrate binding site [chemical binding]; other site
487521003095	oxyanion hole (OAH) forming residues; other site
487521003096	trimer interface [polypeptide binding]; other site
487521003097	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521003098	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
487521003099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
487521003100	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
487521003101	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
487521003102	malonyl-CoA binding site [chemical binding]; other site
487521003103	dimer interface [polypeptide binding]; other site
487521003104	active site
487521003105	product binding site; other site
487521003106	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
487521003107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003108	NAD(P) binding site [chemical binding]; other site
487521003109	active site
487521003110	CAAX protease self-immunity; Region: Abi; pfam02517
487521003111	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
487521003112	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
487521003113	putative NAD(P) binding site [chemical binding]; other site
487521003114	putative active site [active]
487521003115	enoyl-CoA hydratase; Provisional; Region: PRK06688
487521003116	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003117	substrate binding site [chemical binding]; other site
487521003118	oxyanion hole (OAH) forming residues; other site
487521003119	trimer interface [polypeptide binding]; other site
487521003120	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003121	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003122	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
487521003123	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
487521003124	NAD binding site [chemical binding]; other site
487521003125	homodimer interface [polypeptide binding]; other site
487521003126	homotetramer interface [polypeptide binding]; other site
487521003127	active site
487521003128	MMPL family; Region: MMPL; pfam03176
487521003129	MMPL family; Region: MMPL; pfam03176
487521003130	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521003131	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521003132	S-adenosylmethionine binding site [chemical binding]; other site
487521003133	NAD-dependent deacetylase; Provisional; Region: PRK00481
487521003134	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
487521003135	NAD+ binding site [chemical binding]; other site
487521003136	substrate binding site [chemical binding]; other site
487521003137	Zn binding site [ion binding]; other site
487521003138	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521003139	DNA-binding site [nucleotide binding]; DNA binding site
487521003140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
487521003141	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521003142	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
487521003143	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
487521003144	minor groove reading motif; other site
487521003145	mannosyltransferase; Provisional; Region: pimE; PRK13375
487521003146	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
487521003147	aromatic arch; other site
487521003148	DCoH dimer interaction site [polypeptide binding]; other site
487521003149	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
487521003150	DCoH tetramer interaction site [polypeptide binding]; other site
487521003151	substrate binding site [chemical binding]; other site
487521003152	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
487521003153	active site
487521003154	8-oxo-dGMP binding site [chemical binding]; other site
487521003155	nudix motif; other site
487521003156	metal binding site [ion binding]; metal-binding site
487521003157	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
487521003158	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
487521003159	[4Fe-4S] binding site [ion binding]; other site
487521003160	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521003161	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521003162	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521003163	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
487521003164	molybdopterin cofactor binding site; other site
487521003165	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
487521003166	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
487521003167	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
487521003168	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
487521003169	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
487521003170	G1 box; other site
487521003171	putative GEF interaction site [polypeptide binding]; other site
487521003172	GTP/Mg2+ binding site [chemical binding]; other site
487521003173	Switch I region; other site
487521003174	G2 box; other site
487521003175	G3 box; other site
487521003176	Switch II region; other site
487521003177	G4 box; other site
487521003178	G5 box; other site
487521003179	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
487521003180	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
487521003181	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
487521003182	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
487521003183	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
487521003184	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003185	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003186	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
487521003187	FO synthase; Reviewed; Region: fbiC; PRK09234
487521003188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521003189	FeS/SAM binding site; other site
487521003190	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521003191	FeS/SAM binding site; other site
487521003192	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
487521003193	4Fe-4S binding domain; Region: Fer4; pfam00037
487521003194	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
487521003195	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521003196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521003197	homodimer interface [polypeptide binding]; other site
487521003198	catalytic residue [active]
487521003199	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
487521003200	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
487521003201	generic binding surface II; other site
487521003202	ssDNA binding site; other site
487521003203	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
487521003204	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521003205	active site
487521003206	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521003207	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
487521003208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003209	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
487521003210	Enoylreductase; Region: PKS_ER; smart00829
487521003211	NAD(P) binding site [chemical binding]; other site
487521003212	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
487521003213	KR domain; Region: KR; pfam08659
487521003214	putative NADP binding site [chemical binding]; other site
487521003215	active site
487521003216	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521003217	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521003218	PPE family; Region: PPE; pfam00823
487521003219	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521003220	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521003221	PPE family; Region: PPE; pfam00823
487521003222	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521003223	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
487521003224	ligand-binding site [chemical binding]; other site
487521003225	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
487521003226	ATP-sulfurylase; Region: ATPS; cd00517
487521003227	active site
487521003228	HXXH motif; other site
487521003229	flexible loop; other site
487521003230	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
487521003231	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
487521003232	acyl-CoA synthetase; Validated; Region: PRK05850
487521003233	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
487521003234	acyl-activating enzyme (AAE) consensus motif; other site
487521003235	active site
487521003236	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521003237	PPE family; Region: PPE; pfam00823
487521003238	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
487521003239	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
487521003240	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
487521003241	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
487521003242	NAD(P) binding site [chemical binding]; other site
487521003243	catalytic residues [active]
487521003244	Proline dehydrogenase; Region: Pro_dh; cl03282
487521003245	HTH-like domain; Region: HTH_21; pfam13276
487521003246	Integrase core domain; Region: rve; pfam00665
487521003247	Integrase core domain; Region: rve_3; pfam13683
487521003248	Transposase; Region: HTH_Tnp_1; cl17663
487521003249	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521003250	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521003251	Integrase core domain; Region: rve; pfam00665
487521003252	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003253	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003254	lipid-transfer protein; Provisional; Region: PRK07855
487521003255	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003256	active site
487521003257	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
487521003258	putative active site [active]
487521003259	putative catalytic site [active]
487521003260	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521003261	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003262	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521003263	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521003264	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
487521003265	NAD binding site [chemical binding]; other site
487521003266	catalytic residues [active]
487521003267	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521003268	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
487521003269	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521003270	acyl-CoA synthetase; Validated; Region: PRK07787
487521003271	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003272	acyl-activating enzyme (AAE) consensus motif; other site
487521003273	AMP binding site [chemical binding]; other site
487521003274	active site
487521003275	CoA binding site [chemical binding]; other site
487521003276	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521003277	metabolite-proton symporter; Region: 2A0106; TIGR00883
487521003278	putative substrate translocation pore; other site
487521003279	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
487521003280	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
487521003281	putative trimer interface [polypeptide binding]; other site
487521003282	putative CoA binding site [chemical binding]; other site
487521003283	PE family; Region: PE; pfam00934
487521003284	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521003285	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521003286	PPE family; Region: PPE; pfam00823
487521003287	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
487521003288	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
487521003289	metal binding site [ion binding]; metal-binding site
487521003290	putative dimer interface [polypeptide binding]; other site
487521003291	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
487521003292	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
487521003293	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
487521003294	acyl-activating enzyme (AAE) consensus motif; other site
487521003295	putative AMP binding site [chemical binding]; other site
487521003296	putative active site [active]
487521003297	putative CoA binding site [chemical binding]; other site
487521003298	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
487521003299	dihydropteroate synthase; Region: DHPS; TIGR01496
487521003300	substrate binding pocket [chemical binding]; other site
487521003301	dimer interface [polypeptide binding]; other site
487521003302	inhibitor binding site; inhibition site
487521003303	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
487521003304	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
487521003305	DivIVA domain; Region: DivI1A_domain; TIGR03544
487521003306	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
487521003307	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
487521003308	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
487521003309	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521003310	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
487521003311	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
487521003312	ligand binding site; other site
487521003313	oligomer interface; other site
487521003314	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
487521003315	dimer interface [polypeptide binding]; other site
487521003316	N-terminal domain interface [polypeptide binding]; other site
487521003317	sulfate 1 binding site; other site
487521003318	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
487521003319	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
487521003320	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
487521003321	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487521003322	Walker A/P-loop; other site
487521003323	ATP binding site [chemical binding]; other site
487521003324	Q-loop/lid; other site
487521003325	ABC transporter signature motif; other site
487521003326	Walker B; other site
487521003327	D-loop; other site
487521003328	H-loop/switch region; other site
487521003329	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
487521003330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003331	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003332	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
487521003333	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521003334	S-adenosylmethionine binding site [chemical binding]; other site
487521003335	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
487521003336	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521003337	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521003338	DNA binding residues [nucleotide binding]
487521003339	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
487521003340	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
487521003341	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
487521003342	protein binding site [polypeptide binding]; other site
487521003343	sec-independent translocase; Provisional; Region: PRK03100
487521003344	Domain of unknown function DUF59; Region: DUF59; cl00941
487521003345	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
487521003346	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
487521003347	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
487521003348	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
487521003349	N-acetyl-D-glucosamine binding site [chemical binding]; other site
487521003350	catalytic residue [active]
487521003351	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
487521003352	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
487521003353	MgtE intracellular N domain; Region: MgtE_N; smart00924
487521003354	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
487521003355	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
487521003356	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487521003357	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487521003358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521003359	dimer interface [polypeptide binding]; other site
487521003360	conserved gate region; other site
487521003361	putative PBP binding loops; other site
487521003362	ABC-ATPase subunit interface; other site
487521003363	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487521003364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521003365	dimer interface [polypeptide binding]; other site
487521003366	conserved gate region; other site
487521003367	ABC-ATPase subunit interface; other site
487521003368	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
487521003369	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
487521003370	Walker A/P-loop; other site
487521003371	ATP binding site [chemical binding]; other site
487521003372	Q-loop/lid; other site
487521003373	ABC transporter signature motif; other site
487521003374	Walker B; other site
487521003375	D-loop; other site
487521003376	H-loop/switch region; other site
487521003377	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
487521003378	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
487521003379	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
487521003380	oligomer interface [polypeptide binding]; other site
487521003381	metal binding site [ion binding]; metal-binding site
487521003382	metal binding site [ion binding]; metal-binding site
487521003383	putative Cl binding site [ion binding]; other site
487521003384	basic sphincter; other site
487521003385	hydrophobic gate; other site
487521003386	periplasmic entrance; other site
487521003387	malate dehydrogenase; Provisional; Region: PRK05442
487521003388	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
487521003389	NAD(P) binding site [chemical binding]; other site
487521003390	dimer interface [polypeptide binding]; other site
487521003391	malate binding site [chemical binding]; other site
487521003392	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
487521003393	Malic enzyme, N-terminal domain; Region: malic; pfam00390
487521003394	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
487521003395	putative NAD(P) binding site [chemical binding]; other site
487521003396	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
487521003397	short chain dehydrogenase; Provisional; Region: PRK07832
487521003398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003399	NAD(P) binding site [chemical binding]; other site
487521003400	active site
487521003401	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
487521003402	classical (c) SDRs; Region: SDR_c; cd05233
487521003403	NAD(P) binding site [chemical binding]; other site
487521003404	active site
487521003405	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
487521003406	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
487521003407	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
487521003408	TPP-binding site [chemical binding]; other site
487521003409	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
487521003410	dimer interface [polypeptide binding]; other site
487521003411	PYR/PP interface [polypeptide binding]; other site
487521003412	TPP binding site [chemical binding]; other site
487521003413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521003414	Major Facilitator Superfamily; Region: MFS_1; pfam07690
487521003415	putative substrate translocation pore; other site
487521003416	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
487521003417	RNase_H superfamily; Region: RNase_H_2; pfam13482
487521003418	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
487521003419	Part of AAA domain; Region: AAA_19; pfam13245
487521003420	AAA domain; Region: AAA_12; pfam13087
487521003421	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
487521003422	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
487521003423	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
487521003424	ATP binding site [chemical binding]; other site
487521003425	Mg++ binding site [ion binding]; other site
487521003426	motif III; other site
487521003427	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521003428	nucleotide binding region [chemical binding]; other site
487521003429	ATP-binding site [chemical binding]; other site
487521003430	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
487521003431	putative RNA binding site [nucleotide binding]; other site
487521003432	Acyltransferase family; Region: Acyl_transf_3; pfam01757
487521003433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003435	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003436	Cytochrome P450; Region: p450; cl12078
487521003437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
487521003438	Transposase; Region: HTH_Tnp_1; cl17663
487521003439	putative transposase OrfB; Reviewed; Region: PHA02517
487521003440	HTH-like domain; Region: HTH_21; pfam13276
487521003441	Integrase core domain; Region: rve; pfam00665
487521003442	Integrase core domain; Region: rve_3; cl15866
487521003443	Winged helix-turn helix; Region: HTH_29; pfam13551
487521003444	Helix-turn-helix domain; Region: HTH_28; pfam13518
487521003445	Integrase core domain; Region: rve; pfam00665
487521003446	AAA domain; Region: AAA_22; pfam13401
487521003447	TniQ; Region: TniQ; pfam06527
487521003448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521003449	non-specific DNA binding site [nucleotide binding]; other site
487521003450	salt bridge; other site
487521003451	sequence-specific DNA binding site [nucleotide binding]; other site
487521003452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521003453	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
487521003454	Walker A motif; other site
487521003455	ATP binding site [chemical binding]; other site
487521003456	Walker B motif; other site
487521003457	arginine finger; other site
487521003458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003459	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
487521003460	NAD(P) binding site [chemical binding]; other site
487521003461	active site
487521003462	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521003463	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
487521003464	NAD binding site [chemical binding]; other site
487521003465	catalytic residues [active]
487521003466	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521003467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003469	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003470	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003471	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
487521003472	classical (c) SDRs; Region: SDR_c; cd05233
487521003473	NAD(P) binding site [chemical binding]; other site
487521003474	active site
487521003475	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
487521003476	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487521003477	active site
487521003478	inhibitor site; inhibition site
487521003479	dimer interface [polypeptide binding]; other site
487521003480	catalytic residue [active]
487521003481	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003482	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003483	active site
487521003484	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003485	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003486	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521003487	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003488	substrate binding site [chemical binding]; other site
487521003489	oxyanion hole (OAH) forming residues; other site
487521003490	trimer interface [polypeptide binding]; other site
487521003491	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
487521003492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003493	NAD(P) binding site [chemical binding]; other site
487521003494	active site
487521003495	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
487521003496	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
487521003497	acyl-activating enzyme (AAE) consensus motif; other site
487521003498	putative AMP binding site [chemical binding]; other site
487521003499	putative active site [active]
487521003500	putative CoA binding site [chemical binding]; other site
487521003501	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
487521003502	active site
487521003503	enoyl-CoA hydratase; Provisional; Region: PRK08290
487521003504	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003505	substrate binding site [chemical binding]; other site
487521003506	oxyanion hole (OAH) forming residues; other site
487521003507	trimer interface [polypeptide binding]; other site
487521003508	MarR family; Region: MarR_2; pfam12802
487521003509	Ferritin-like domain; Region: Ferritin; pfam00210
487521003510	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
487521003511	dimerization interface [polypeptide binding]; other site
487521003512	DPS ferroxidase diiron center [ion binding]; other site
487521003513	ion pore; other site
487521003514	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521003515	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003517	AMP binding site [chemical binding]; other site
487521003518	active site
487521003519	acyl-activating enzyme (AAE) consensus motif; other site
487521003520	CoA binding site [chemical binding]; other site
487521003521	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003522	Cytochrome P450; Region: p450; cl12078
487521003523	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521003524	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521003525	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003526	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003527	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003528	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003529	active site
487521003530	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521003531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003532	NAD(P) binding site [chemical binding]; other site
487521003533	active site
487521003534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003535	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
487521003536	NAD(P) binding site [chemical binding]; other site
487521003537	active site
487521003538	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
487521003539	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003540	active site
487521003541	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003542	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003543	active site
487521003544	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003545	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003546	active site
487521003547	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521003548	short chain dehydrogenase; Provisional; Region: PRK06940
487521003549	classical (c) SDRs; Region: SDR_c; cd05233
487521003550	NAD(P) binding site [chemical binding]; other site
487521003551	active site
487521003552	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
487521003553	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521003554	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003555	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
487521003556	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521003557	dimer interface [polypeptide binding]; other site
487521003558	active site
487521003559	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003560	Cytochrome P450; Region: p450; cl12078
487521003561	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003562	Cytochrome P450; Region: p450; cl12078
487521003563	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521003564	dimerization interface [polypeptide binding]; other site
487521003565	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521003566	cyclase homology domain; Region: CHD; cd07302
487521003567	nucleotidyl binding site; other site
487521003568	metal binding site [ion binding]; metal-binding site
487521003569	dimer interface [polypeptide binding]; other site
487521003570	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
487521003571	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
487521003572	tetrameric interface [polypeptide binding]; other site
487521003573	NAD binding site [chemical binding]; other site
487521003574	catalytic residues [active]
487521003575	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
487521003576	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
487521003577	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003578	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003579	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521003580	Permease; Region: Permease; pfam02405
487521003581	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521003582	Permease; Region: Permease; pfam02405
487521003583	mce related protein; Region: MCE; pfam02470
487521003584	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521003585	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521003586	mce related protein; Region: MCE; pfam02470
487521003587	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521003588	mce related protein; Region: MCE; pfam02470
487521003589	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521003590	mce related protein; Region: MCE; pfam02470
487521003591	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521003592	mce related protein; Region: MCE; pfam02470
487521003593	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521003594	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521003595	mce related protein; Region: MCE; pfam02470
487521003596	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
487521003597	active site
487521003598	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
487521003599	catalytic triad [active]
487521003600	dimer interface [polypeptide binding]; other site
487521003601	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
487521003602	Transposase; Region: HTH_Tnp_1; cl17663
487521003603	Homeodomain-like domain; Region: HTH_23; cl17451
487521003604	HTH-like domain; Region: HTH_21; pfam13276
487521003605	Integrase core domain; Region: rve; pfam00665
487521003606	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003607	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003608	Transcriptional regulators [Transcription]; Region: FadR; COG2186
487521003609	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521003610	DNA-binding site [nucleotide binding]; DNA binding site
487521003611	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
487521003612	5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555
487521003613	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521003614	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521003615	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521003616	[2Fe-2S] cluster binding site [ion binding]; other site
487521003617	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521003618	hydrophobic ligand binding site; other site
487521003619	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003620	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003621	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
487521003622	catalytic triad [active]
487521003623	conserved cis-peptide bond; other site
487521003624	acyl-CoA synthetase; Provisional; Region: PRK13391
487521003625	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003626	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521003627	acyl-activating enzyme (AAE) consensus motif; other site
487521003628	putative AMP binding site [chemical binding]; other site
487521003629	putative active site [active]
487521003630	putative CoA binding site [chemical binding]; other site
487521003631	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003632	Cytochrome P450; Region: p450; cl12078
487521003633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003634	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521003635	NAD(P) binding site [chemical binding]; other site
487521003636	active site
487521003637	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521003638	classical (c) SDRs; Region: SDR_c; cd05233
487521003639	NAD(P) binding site [chemical binding]; other site
487521003640	active site
487521003641	enoyl-CoA hydratase; Provisional; Region: PRK06563
487521003642	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003643	substrate binding site [chemical binding]; other site
487521003644	oxyanion hole (OAH) forming residues; other site
487521003645	trimer interface [polypeptide binding]; other site
487521003646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003647	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521003648	NAD(P) binding site [chemical binding]; other site
487521003649	active site
487521003650	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003651	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003652	active site
487521003653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003654	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003655	active site
487521003656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003657	NAD(P) binding site [chemical binding]; other site
487521003658	active site
487521003659	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003660	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
487521003661	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003662	active site
487521003663	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521003664	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003665	substrate binding site [chemical binding]; other site
487521003666	oxyanion hole (OAH) forming residues; other site
487521003667	trimer interface [polypeptide binding]; other site
487521003668	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
487521003669	active site 2 [active]
487521003670	Transcriptional regulators [Transcription]; Region: FadR; COG2186
487521003671	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521003672	DNA-binding site [nucleotide binding]; DNA binding site
487521003673	FCD domain; Region: FCD; pfam07729
487521003674	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003675	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003676	active site
487521003677	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003678	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003679	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003680	active site
487521003681	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
487521003682	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
487521003683	NAD binding site [chemical binding]; other site
487521003684	catalytic residues [active]
487521003685	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003686	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003687	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521003688	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521003689	active site
487521003690	metal binding site [ion binding]; metal-binding site
487521003691	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003692	NAD(P) binding site [chemical binding]; other site
487521003693	active site
487521003694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003695	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
487521003696	NAD(P) binding site [chemical binding]; other site
487521003697	active site
487521003698	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
487521003699	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003700	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521003701	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521003702	active site
487521003703	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003704	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003705	active site
487521003706	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521003707	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003708	acyl-activating enzyme (AAE) consensus motif; other site
487521003709	AMP binding site [chemical binding]; other site
487521003710	active site
487521003711	CoA binding site [chemical binding]; other site
487521003712	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003713	Cytochrome P450; Region: p450; cl12078
487521003714	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
487521003715	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003716	active site
487521003717	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521003718	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521003719	acyl-activating enzyme (AAE) consensus motif; other site
487521003720	putative AMP binding site [chemical binding]; other site
487521003721	putative active site [active]
487521003722	putative CoA binding site [chemical binding]; other site
487521003723	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521003724	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521003725	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521003726	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003727	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003728	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
487521003729	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
487521003730	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003731	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521003732	putative acyltransferase; Provisional; Region: PRK05790
487521003733	dimer interface [polypeptide binding]; other site
487521003734	active site
487521003735	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
487521003736	putative active site [active]
487521003737	putative catalytic site [active]
487521003738	lipid-transfer protein; Provisional; Region: PRK07855
487521003739	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003740	active site
487521003741	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
487521003742	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003743	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521003744	acyl-activating enzyme (AAE) consensus motif; other site
487521003745	putative AMP binding site [chemical binding]; other site
487521003746	putative active site [active]
487521003747	putative CoA binding site [chemical binding]; other site
487521003748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003750	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003751	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003752	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521003753	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003754	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003755	active site
487521003756	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
487521003757	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003758	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003759	active site
487521003760	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521003761	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003762	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003763	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003764	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003765	active site
487521003766	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521003767	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003768	active site
487521003769	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521003770	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003771	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003772	AMP binding site [chemical binding]; other site
487521003773	active site
487521003774	acyl-activating enzyme (AAE) consensus motif; other site
487521003775	acyl-activating enzyme (AAE) consensus motif; other site
487521003776	CoA binding site [chemical binding]; other site
487521003777	enoyl-CoA hydratase; Provisional; Region: PRK08252
487521003778	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003779	substrate binding site [chemical binding]; other site
487521003780	oxyanion hole (OAH) forming residues; other site
487521003781	trimer interface [polypeptide binding]; other site
487521003782	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521003783	classical (c) SDRs; Region: SDR_c; cd05233
487521003784	NAD(P) binding site [chemical binding]; other site
487521003785	active site
487521003786	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521003787	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521003788	active site 2 [active]
487521003789	active site 1 [active]
487521003790	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003791	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003792	active site
487521003793	enoyl-CoA hydratase; Provisional; Region: PRK06688
487521003794	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003795	substrate binding site [chemical binding]; other site
487521003796	oxyanion hole (OAH) forming residues; other site
487521003797	trimer interface [polypeptide binding]; other site
487521003798	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521003799	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487521003800	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
487521003801	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521003802	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521003803	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521003804	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003805	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003806	active site
487521003807	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
487521003808	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521003809	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
487521003810	NAD(P) binding site [chemical binding]; other site
487521003811	catalytic residues [active]
487521003812	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003813	enoyl-CoA hydratase; Provisional; Region: PRK07799
487521003814	substrate binding site [chemical binding]; other site
487521003815	oxyanion hole (OAH) forming residues; other site
487521003816	trimer interface [polypeptide binding]; other site
487521003817	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
487521003818	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003819	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521003820	acyl-activating enzyme (AAE) consensus motif; other site
487521003821	putative AMP binding site [chemical binding]; other site
487521003822	putative active site [active]
487521003823	putative CoA binding site [chemical binding]; other site
487521003824	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
487521003825	inter-subunit interface; other site
487521003826	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521003827	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521003828	iron-sulfur cluster [ion binding]; other site
487521003829	[2Fe-2S] cluster binding site [ion binding]; other site
487521003830	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
487521003831	putative alpha subunit interface [polypeptide binding]; other site
487521003832	putative active site [active]
487521003833	putative substrate binding site [chemical binding]; other site
487521003834	Fe binding site [ion binding]; other site
487521003835	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003836	lipid-transfer protein; Provisional; Region: PRK07855
487521003837	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003838	active site
487521003839	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521003840	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
487521003841	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
487521003842	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
487521003843	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003844	active site
487521003845	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521003846	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003847	active site
487521003848	thiolase; Provisional; Region: PRK06158
487521003849	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003850	active site
487521003851	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521003852	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003853	acyl-activating enzyme (AAE) consensus motif; other site
487521003854	AMP binding site [chemical binding]; other site
487521003855	active site
487521003856	CoA binding site [chemical binding]; other site
487521003857	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521003858	classical (c) SDRs; Region: SDR_c; cd05233
487521003859	NAD(P) binding site [chemical binding]; other site
487521003860	active site
487521003861	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521003862	CoenzymeA binding site [chemical binding]; other site
487521003863	subunit interaction site [polypeptide binding]; other site
487521003864	PHB binding site; other site
487521003865	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003866	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003867	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003868	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003869	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003870	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003871	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521003872	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003873	lipid-transfer protein; Provisional; Region: PRK07855
487521003874	active site
487521003875	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521003876	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003877	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003879	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003880	Cytochrome P450; Region: p450; cl12078
487521003881	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
487521003882	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521003883	classical (c) SDRs; Region: SDR_c; cd05233
487521003884	NAD(P) binding site [chemical binding]; other site
487521003885	active site
487521003886	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
487521003887	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
487521003888	acyl-activating enzyme (AAE) consensus motif; other site
487521003889	putative AMP binding site [chemical binding]; other site
487521003890	putative active site [active]
487521003891	putative CoA binding site [chemical binding]; other site
487521003892	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521003893	short chain dehydrogenase; Provisional; Region: PRK07791
487521003894	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003895	NAD(P) binding site [chemical binding]; other site
487521003896	active site
487521003897	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
487521003898	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521003899	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003900	enoyl-CoA hydratase; Provisional; Region: PRK06688
487521003901	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521003902	substrate binding site [chemical binding]; other site
487521003903	oxyanion hole (OAH) forming residues; other site
487521003904	trimer interface [polypeptide binding]; other site
487521003905	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003906	Cytochrome P450; Region: p450; cl12078
487521003907	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
487521003908	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
487521003909	classical (c) SDRs; Region: SDR_c; cd05233
487521003910	NAD(P) binding site [chemical binding]; other site
487521003911	active site
487521003912	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
487521003913	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
487521003914	NAD binding site [chemical binding]; other site
487521003915	catalytic Zn binding site [ion binding]; other site
487521003916	substrate binding site [chemical binding]; other site
487521003917	structural Zn binding site [ion binding]; other site
487521003918	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
487521003919	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521003920	NAD binding site [chemical binding]; other site
487521003921	catalytic residues [active]
487521003922	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
487521003923	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521003924	active site 2 [active]
487521003925	active site 1 [active]
487521003926	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003927	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521003929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003930	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003931	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003932	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521003933	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521003934	3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370
487521003935	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
487521003936	active site
487521003937	metal binding site [ion binding]; metal-binding site
487521003938	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521003939	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521003940	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521003941	Cytochrome P450; Region: p450; cl12078
487521003942	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521003943	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521003944	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
487521003945	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
487521003946	putative FMN binding site [chemical binding]; other site
487521003947	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003948	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521003949	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003950	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003951	active site
487521003952	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003953	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003954	active site
487521003955	lipid-transfer protein; Provisional; Region: PRK07855
487521003956	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521003957	active site
487521003958	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003959	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521003960	classical (c) SDRs; Region: SDR_c; cd05233
487521003961	NAD(P) binding site [chemical binding]; other site
487521003962	active site
487521003963	Ecdysteroid kinase; Region: EcKinase; cl17738
487521003964	Phosphotransferase enzyme family; Region: APH; pfam01636
487521003965	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521003966	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521003967	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521003968	active site
487521003969	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521003970	short chain dehydrogenase; Provisional; Region: PRK06197
487521003971	NAD(P) binding site [chemical binding]; other site
487521003972	active site
487521003973	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521003974	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003975	acyl-activating enzyme (AAE) consensus motif; other site
487521003976	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521003977	AMP binding site [chemical binding]; other site
487521003978	active site
487521003979	acyl-activating enzyme (AAE) consensus motif; other site
487521003980	CoA binding site [chemical binding]; other site
487521003981	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521003982	MarR family; Region: MarR_2; pfam12802
487521003983	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
487521003984	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
487521003985	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
487521003986	active site
487521003987	catalytic residues [active]
487521003988	metal binding site [ion binding]; metal-binding site
487521003989	DmpG-like communication domain; Region: DmpG_comm; pfam07836
487521003990	acetaldehyde dehydrogenase; Validated; Region: PRK08300
487521003991	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
487521003992	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
487521003993	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
487521003994	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
487521003995	dimer interface [polypeptide binding]; other site
487521003996	PYR/PP interface [polypeptide binding]; other site
487521003997	TPP binding site [chemical binding]; other site
487521003998	substrate binding site [chemical binding]; other site
487521003999	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
487521004000	TPP-binding site [chemical binding]; other site
487521004001	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
487521004002	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
487521004003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521004004	putative DNA binding site [nucleotide binding]; other site
487521004005	putative Zn2+ binding site [ion binding]; other site
487521004006	AsnC family; Region: AsnC_trans_reg; pfam01037
487521004007	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521004008	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521004009	iron-sulfur cluster [ion binding]; other site
487521004010	[2Fe-2S] cluster binding site [ion binding]; other site
487521004011	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
487521004012	beta subunit interface [polypeptide binding]; other site
487521004013	alpha subunit interface [polypeptide binding]; other site
487521004014	active site
487521004015	substrate binding site [chemical binding]; other site
487521004016	Fe binding site [ion binding]; other site
487521004017	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
487521004018	inter-subunit interface; other site
487521004019	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
487521004020	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521004021	NAD(P) binding site [chemical binding]; other site
487521004022	active site
487521004023	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
487521004024	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521004025	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
487521004026	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521004027	Bacterial transcriptional regulator; Region: IclR; pfam01614
487521004028	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521004029	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521004030	MarR family; Region: MarR; pfam01047
487521004031	MarR family; Region: MarR_2; cl17246
487521004032	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521004033	Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107
487521004034	NAD(P) binding site [chemical binding]; other site
487521004035	catalytic residues [active]
487521004036	catalytic residues [active]
487521004037	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487521004038	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
487521004039	active site
487521004040	metal binding site [ion binding]; metal-binding site
487521004041	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
487521004042	active site
487521004043	metal binding site [ion binding]; metal-binding site
487521004044	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
487521004045	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
487521004046	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
487521004047	hexamer interface [polypeptide binding]; other site
487521004048	active site 2 [active]
487521004049	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521004050	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
487521004051	NAD binding site [chemical binding]; other site
487521004052	catalytic residues [active]
487521004053	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487521004054	Class I aldolases; Region: Aldolase_Class_I; cl17187
487521004055	catalytic residue [active]
487521004056	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
487521004057	Cupin domain; Region: Cupin_2; pfam07883
487521004058	Cupin domain; Region: Cupin_2; pfam07883
487521004059	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521004060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521004061	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
487521004062	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004063	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004064	active site
487521004065	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521004066	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521004067	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521004068	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521004069	active site
487521004070	metal binding site [ion binding]; metal-binding site
487521004071	classical (c) SDRs; Region: SDR_c; cd05233
487521004072	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
487521004073	NAD(P) binding site [chemical binding]; other site
487521004074	active site
487521004075	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521004076	iron-sulfur cluster [ion binding]; other site
487521004077	[2Fe-2S] cluster binding site [ion binding]; other site
487521004078	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521004079	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521004080	hydrophobic ligand binding site; other site
487521004081	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521004082	YceI-like domain; Region: YceI; pfam04264
487521004083	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
487521004084	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
487521004085	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521004086	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521004087	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521004088	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521004089	Permease; Region: Permease; pfam02405
487521004090	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521004091	Permease; Region: Permease; pfam02405
487521004092	mce related protein; Region: MCE; pfam02470
487521004093	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521004094	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521004095	mce related protein; Region: MCE; pfam02470
487521004096	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521004097	mce related protein; Region: MCE; pfam02470
487521004098	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
487521004099	mce related protein; Region: MCE; pfam02470
487521004100	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521004101	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521004102	mce related protein; Region: MCE; pfam02470
487521004103	FAD binding domain; Region: FAD_binding_4; pfam01565
487521004104	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
487521004105	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
487521004106	Fe-S cluster binding site [ion binding]; other site
487521004107	DNA binding site [nucleotide binding]
487521004108	active site
487521004109	hypothetical protein; Validated; Region: PRK05868
487521004110	hypothetical protein; Provisional; Region: PRK07236
487521004111	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
487521004112	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521004113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
487521004114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
487521004115	metal binding site [ion binding]; metal-binding site
487521004116	active site
487521004117	I-site; other site
487521004118	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
487521004119	metal binding site [ion binding]; metal-binding site
487521004120	active site
487521004121	I-site; other site
487521004122	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
487521004123	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
487521004124	HIT family signature motif; other site
487521004125	catalytic residue [active]
487521004126	amidase; Provisional; Region: PRK12470
487521004127	Amidase; Region: Amidase; pfam01425
487521004128	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
487521004129	putative active site [active]
487521004130	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521004131	cyclase homology domain; Region: CHD; cd07302
487521004132	nucleotidyl binding site; other site
487521004133	metal binding site [ion binding]; metal-binding site
487521004134	dimer interface [polypeptide binding]; other site
487521004135	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521004136	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521004137	active site
487521004138	ATP binding site [chemical binding]; other site
487521004139	substrate binding site [chemical binding]; other site
487521004140	activation loop (A-loop); other site
487521004141	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521004142	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487521004143	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
487521004144	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487521004145	Walker A/P-loop; other site
487521004146	ATP binding site [chemical binding]; other site
487521004147	Q-loop/lid; other site
487521004148	ABC transporter signature motif; other site
487521004149	Walker B; other site
487521004150	D-loop; other site
487521004151	H-loop/switch region; other site
487521004152	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487521004153	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487521004154	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521004155	Walker A/P-loop; other site
487521004156	ATP binding site [chemical binding]; other site
487521004157	Q-loop/lid; other site
487521004158	ABC transporter signature motif; other site
487521004159	Walker B; other site
487521004160	D-loop; other site
487521004161	H-loop/switch region; other site
487521004162	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
487521004163	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
487521004164	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521004165	catalytic core [active]
487521004166	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
487521004167	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
487521004168	active site
487521004169	metal binding site [ion binding]; metal-binding site
487521004170	DNA binding site [nucleotide binding]
487521004171	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521004172	Walker A/P-loop; other site
487521004173	ATP binding site [chemical binding]; other site
487521004174	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521004175	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
487521004176	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
487521004177	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
487521004178	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
487521004179	Walker A/P-loop; other site
487521004180	ATP binding site [chemical binding]; other site
487521004181	Q-loop/lid; other site
487521004182	ABC transporter signature motif; other site
487521004183	Walker B; other site
487521004184	D-loop; other site
487521004185	H-loop/switch region; other site
487521004186	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
487521004187	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487521004188	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
487521004189	Walker A/P-loop; other site
487521004190	ATP binding site [chemical binding]; other site
487521004191	Q-loop/lid; other site
487521004192	ABC transporter signature motif; other site
487521004193	Walker B; other site
487521004194	D-loop; other site
487521004195	H-loop/switch region; other site
487521004196	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
487521004197	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
487521004198	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
487521004199	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521004200	dimer interface [polypeptide binding]; other site
487521004201	conserved gate region; other site
487521004202	putative PBP binding loops; other site
487521004203	ABC-ATPase subunit interface; other site
487521004204	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
487521004205	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521004206	dimer interface [polypeptide binding]; other site
487521004207	conserved gate region; other site
487521004208	putative PBP binding loops; other site
487521004209	ABC-ATPase subunit interface; other site
487521004210	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
487521004211	active site clefts [active]
487521004212	zinc binding site [ion binding]; other site
487521004213	dimer interface [polypeptide binding]; other site
487521004214	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521004215	CoenzymeA binding site [chemical binding]; other site
487521004216	subunit interaction site [polypeptide binding]; other site
487521004217	PHB binding site; other site
487521004218	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
487521004219	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
487521004220	Active Sites [active]
487521004221	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
487521004222	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
487521004223	CysD dimerization site [polypeptide binding]; other site
487521004224	G1 box; other site
487521004225	putative GEF interaction site [polypeptide binding]; other site
487521004226	GTP/Mg2+ binding site [chemical binding]; other site
487521004227	Switch I region; other site
487521004228	G2 box; other site
487521004229	G3 box; other site
487521004230	Switch II region; other site
487521004231	G4 box; other site
487521004232	G5 box; other site
487521004233	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
487521004234	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
487521004235	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
487521004236	ligand-binding site [chemical binding]; other site
487521004237	Rrf2 family protein; Region: rrf2_super; TIGR00738
487521004238	Transcriptional regulator; Region: Rrf2; pfam02082
487521004239	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
487521004240	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521004241	metal binding site [ion binding]; metal-binding site
487521004242	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487521004243	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521004244	active site
487521004245	metal binding site [ion binding]; metal-binding site
487521004246	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521004247	Tetratricopeptide repeat; Region: TPR_12; pfam13424
487521004248	TrkA-N domain; Region: TrkA_N; pfam02254
487521004249	Ion channel; Region: Ion_trans_2; pfam07885
487521004250	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
487521004251	TrkA-N domain; Region: TrkA_N; pfam02254
487521004252	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521004253	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
487521004254	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
487521004255	dimer interface [polypeptide binding]; other site
487521004256	ADP-ribose binding site [chemical binding]; other site
487521004257	active site
487521004258	nudix motif; other site
487521004259	metal binding site [ion binding]; metal-binding site
487521004260	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
487521004261	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
487521004262	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
487521004263	active site
487521004264	HIGH motif; other site
487521004265	KMSK motif region; other site
487521004266	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
487521004267	tRNA binding surface [nucleotide binding]; other site
487521004268	anticodon binding site; other site
487521004269	diaminopimelate decarboxylase; Region: lysA; TIGR01048
487521004270	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
487521004271	active site
487521004272	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487521004273	substrate binding site [chemical binding]; other site
487521004274	catalytic residues [active]
487521004275	dimer interface [polypeptide binding]; other site
487521004276	homoserine dehydrogenase; Provisional; Region: PRK06349
487521004277	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
487521004278	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
487521004279	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
487521004280	threonine synthase; Reviewed; Region: PRK06721
487521004281	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
487521004282	homodimer interface [polypeptide binding]; other site
487521004283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521004284	catalytic residue [active]
487521004285	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
487521004286	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
487521004287	transcription termination factor Rho; Provisional; Region: PRK12608
487521004288	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
487521004289	RNA binding site [nucleotide binding]; other site
487521004290	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
487521004291	multimer interface [polypeptide binding]; other site
487521004292	Walker A motif; other site
487521004293	ATP binding site [chemical binding]; other site
487521004294	Walker B motif; other site
487521004295	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
487521004296	peptide chain release factor 1; Validated; Region: prfA; PRK00591
487521004297	This domain is found in peptide chain release factors; Region: PCRF; smart00937
487521004298	RF-1 domain; Region: RF-1; pfam00472
487521004299	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
487521004300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521004301	S-adenosylmethionine binding site [chemical binding]; other site
487521004302	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
487521004303	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
487521004304	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
487521004305	Mg++ binding site [ion binding]; other site
487521004306	putative catalytic motif [active]
487521004307	substrate binding site [chemical binding]; other site
487521004308	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
487521004309	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
487521004310	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
487521004311	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
487521004312	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
487521004313	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
487521004314	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
487521004315	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
487521004316	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
487521004317	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
487521004318	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
487521004319	beta subunit interaction interface [polypeptide binding]; other site
487521004320	Walker A motif; other site
487521004321	ATP binding site [chemical binding]; other site
487521004322	Walker B motif; other site
487521004323	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
487521004324	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
487521004325	core domain interface [polypeptide binding]; other site
487521004326	delta subunit interface [polypeptide binding]; other site
487521004327	epsilon subunit interface [polypeptide binding]; other site
487521004328	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
487521004329	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
487521004330	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
487521004331	alpha subunit interaction interface [polypeptide binding]; other site
487521004332	Walker A motif; other site
487521004333	ATP binding site [chemical binding]; other site
487521004334	Walker B motif; other site
487521004335	inhibitor binding site; inhibition site
487521004336	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
487521004337	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
487521004338	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
487521004339	gamma subunit interface [polypeptide binding]; other site
487521004340	epsilon subunit interface [polypeptide binding]; other site
487521004341	LBP interface [polypeptide binding]; other site
487521004342	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
487521004343	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
487521004344	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
487521004345	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
487521004346	hinge; other site
487521004347	active site
487521004348	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521004349	PPE family; Region: PPE; pfam00823
487521004350	PE family; Region: PE; pfam00934
487521004351	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521004352	PPE family; Region: PPE; pfam00823
487521004353	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521004354	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
487521004355	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
487521004356	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
487521004357	DNA binding site [nucleotide binding]
487521004358	active site
487521004359	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
487521004360	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
487521004361	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521004362	AlkA N-terminal domain; Region: AlkA_N; pfam06029
487521004363	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
487521004364	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
487521004365	minor groove reading motif; other site
487521004366	helix-hairpin-helix signature motif; other site
487521004367	substrate binding pocket [chemical binding]; other site
487521004368	active site
487521004369	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
487521004370	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
487521004371	metal binding site [ion binding]; metal-binding site
487521004372	active site
487521004373	I-site; other site
487521004374	HAMP domain; Region: HAMP; pfam00672
487521004375	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521004376	cyclase homology domain; Region: CHD; cd07302
487521004377	nucleotidyl binding site; other site
487521004378	metal binding site [ion binding]; metal-binding site
487521004379	dimer interface [polypeptide binding]; other site
487521004380	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
487521004381	hypothetical protein; Provisional; Region: PRK03298
487521004382	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
487521004383	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521004384	dimer interface [polypeptide binding]; other site
487521004385	substrate binding site [chemical binding]; other site
487521004386	metal binding site [ion binding]; metal-binding site
487521004387	putative acyltransferase; Provisional; Region: PRK05790
487521004388	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521004389	dimer interface [polypeptide binding]; other site
487521004390	active site
487521004391	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
487521004392	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
487521004393	glycogen branching enzyme; Provisional; Region: PRK05402
487521004394	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
487521004395	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
487521004396	active site
487521004397	catalytic site [active]
487521004398	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
487521004399	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
487521004400	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
487521004401	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
487521004402	active site
487521004403	homodimer interface [polypeptide binding]; other site
487521004404	catalytic site [active]
487521004405	acceptor binding site [chemical binding]; other site
487521004406	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
487521004407	putative homodimer interface [polypeptide binding]; other site
487521004408	putative active site pocket [active]
487521004409	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
487521004410	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
487521004411	DEAD/DEAH box helicase; Region: DEAD; pfam00270
487521004412	ATP binding site [chemical binding]; other site
487521004413	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
487521004414	putative Mg++ binding site [ion binding]; other site
487521004415	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
487521004416	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
487521004417	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
487521004418	active site
487521004419	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
487521004420	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
487521004421	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
487521004422	putative active site pocket [active]
487521004423	cleavage site
487521004424	Rhomboid family; Region: Rhomboid; pfam01694
487521004425	glutamate racemase; Provisional; Region: PRK00865
487521004426	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
487521004427	ribonuclease PH; Reviewed; Region: rph; PRK00173
487521004428	Ribonuclease PH; Region: RNase_PH_bact; cd11362
487521004429	hexamer interface [polypeptide binding]; other site
487521004430	active site
487521004431	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
487521004432	active site
487521004433	dimerization interface [polypeptide binding]; other site
487521004434	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
487521004435	Glucitol operon activator protein (GutM); Region: GutM; cl01890
487521004436	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
487521004437	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
487521004438	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
487521004439	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
487521004440	FAD binding pocket [chemical binding]; other site
487521004441	FAD binding motif [chemical binding]; other site
487521004442	phosphate binding motif [ion binding]; other site
487521004443	NAD binding pocket [chemical binding]; other site
487521004444	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487521004445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521004446	Walker A/P-loop; other site
487521004447	ATP binding site [chemical binding]; other site
487521004448	Q-loop/lid; other site
487521004449	ABC transporter signature motif; other site
487521004450	Walker B; other site
487521004451	D-loop; other site
487521004452	H-loop/switch region; other site
487521004453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521004454	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487521004455	Walker A/P-loop; other site
487521004456	ATP binding site [chemical binding]; other site
487521004457	Q-loop/lid; other site
487521004458	ABC transporter signature motif; other site
487521004459	Walker B; other site
487521004460	D-loop; other site
487521004461	H-loop/switch region; other site
487521004462	Phosphotransferase enzyme family; Region: APH; pfam01636
487521004463	Ecdysteroid kinase; Region: EcKinase; cl17738
487521004464	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521004465	cyclase homology domain; Region: CHD; cd07302
487521004466	nucleotidyl binding site; other site
487521004467	metal binding site [ion binding]; metal-binding site
487521004468	dimer interface [polypeptide binding]; other site
487521004469	Predicted ATPase [General function prediction only]; Region: COG3903
487521004470	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521004471	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521004472	DNA binding residues [nucleotide binding]
487521004473	dimerization interface [polypeptide binding]; other site
487521004474	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521004475	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521004476	classical (c) SDRs; Region: SDR_c; cd05233
487521004477	NAD(P) binding site [chemical binding]; other site
487521004478	active site
487521004479	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004480	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004481	active site
487521004482	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521004483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521004484	NAD(P) binding site [chemical binding]; other site
487521004485	active site
487521004486	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
487521004487	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521004488	dimer interface [polypeptide binding]; other site
487521004489	active site
487521004490	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
487521004491	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521004492	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004493	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004494	active site
487521004495	Transcriptional regulators [Transcription]; Region: FadR; COG2186
487521004496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521004497	DNA-binding site [nucleotide binding]; DNA binding site
487521004498	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
487521004499	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
487521004500	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
487521004501	conserved cys residue [active]
487521004502	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521004503	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521004504	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
487521004505	conserved cys residue [active]
487521004506	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521004507	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521004508	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521004509	acyl-activating enzyme (AAE) consensus motif; other site
487521004510	acyl-activating enzyme (AAE) consensus motif; other site
487521004511	AMP binding site [chemical binding]; other site
487521004512	active site
487521004513	CoA binding site [chemical binding]; other site
487521004514	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521004515	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521004516	acyl-activating enzyme (AAE) consensus motif; other site
487521004517	AMP binding site [chemical binding]; other site
487521004518	active site
487521004519	CoA binding site [chemical binding]; other site
487521004520	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521004521	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521004522	AMP binding site [chemical binding]; other site
487521004523	active site
487521004524	acyl-activating enzyme (AAE) consensus motif; other site
487521004525	CoA binding site [chemical binding]; other site
487521004526	enoyl-CoA hydratase; Provisional; Region: PRK05981
487521004527	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521004528	substrate binding site [chemical binding]; other site
487521004529	oxyanion hole (OAH) forming residues; other site
487521004530	trimer interface [polypeptide binding]; other site
487521004531	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521004532	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521004533	substrate binding site [chemical binding]; other site
487521004534	oxyanion hole (OAH) forming residues; other site
487521004535	trimer interface [polypeptide binding]; other site
487521004536	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521004537	substrate binding site [chemical binding]; other site
487521004538	oxyanion hole (OAH) forming residues; other site
487521004539	trimer interface [polypeptide binding]; other site
487521004540	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521004541	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
487521004542	substrate binding site [chemical binding]; other site
487521004543	oxyanion hole (OAH) forming residues; other site
487521004544	trimer interface [polypeptide binding]; other site
487521004545	tetracycline repressor protein TetR; Provisional; Region: PRK13756
487521004546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521004547	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
487521004548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521004549	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521004550	NAD(P) binding site [chemical binding]; other site
487521004551	active site
487521004552	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487521004553	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
487521004554	active site
487521004555	inhibitor site; inhibition site
487521004556	dimer interface [polypeptide binding]; other site
487521004557	catalytic residue [active]
487521004558	CsbD-like; Region: CsbD; cl17424
487521004559	enoyl-CoA hydratase; Provisional; Region: PRK06210
487521004560	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521004561	substrate binding site [chemical binding]; other site
487521004562	oxyanion hole (OAH) forming residues; other site
487521004563	trimer interface [polypeptide binding]; other site
487521004564	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521004565	acyl-CoA synthetase; Validated; Region: PRK07798
487521004566	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521004567	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
487521004568	acyl-activating enzyme (AAE) consensus motif; other site
487521004569	acyl-activating enzyme (AAE) consensus motif; other site
487521004570	putative AMP binding site [chemical binding]; other site
487521004571	putative active site [active]
487521004572	putative CoA binding site [chemical binding]; other site
487521004573	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521004574	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
487521004575	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521004576	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004577	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004578	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004579	active site
487521004580	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521004581	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
487521004582	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521004583	active site
487521004584	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521004585	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521004586	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521004587	Cytochrome P450; Region: p450; cl12078
487521004588	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
487521004589	NAD(P) binding site [chemical binding]; other site
487521004590	catalytic residues [active]
487521004591	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521004592	Cytochrome P450; Region: p450; cl12078
487521004593	short chain dehydrogenase; Provisional; Region: PRK07832
487521004594	classical (c) SDRs; Region: SDR_c; cd05233
487521004595	NAD(P) binding site [chemical binding]; other site
487521004596	active site
487521004597	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521004598	hydrophobic ligand binding site; other site
487521004599	acyl-CoA synthetase; Validated; Region: PRK07798
487521004600	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521004601	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
487521004602	acyl-activating enzyme (AAE) consensus motif; other site
487521004603	acyl-activating enzyme (AAE) consensus motif; other site
487521004604	putative AMP binding site [chemical binding]; other site
487521004605	putative active site [active]
487521004606	putative CoA binding site [chemical binding]; other site
487521004607	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521004608	CoenzymeA binding site [chemical binding]; other site
487521004609	subunit interaction site [polypeptide binding]; other site
487521004610	PHB binding site; other site
487521004611	Isochorismatase family; Region: Isochorismatase; pfam00857
487521004612	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
487521004613	catalytic triad [active]
487521004614	conserved cis-peptide bond; other site
487521004615	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521004616	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521004617	[2Fe-2S] cluster binding site [ion binding]; other site
487521004618	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521004619	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521004620	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521004621	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521004622	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
487521004623	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521004624	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521004625	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
487521004626	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
487521004627	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521004628	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521004629	Cytochrome P450; Region: p450; cl12078
487521004630	short chain dehydrogenase; Provisional; Region: PRK06197
487521004631	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521004632	NAD(P) binding site [chemical binding]; other site
487521004633	active site
487521004634	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521004635	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521004636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521004637	Walker A/P-loop; other site
487521004638	ATP binding site [chemical binding]; other site
487521004639	Predicted membrane protein [Function unknown]; Region: COG1511
487521004640	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
487521004641	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
487521004642	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
487521004643	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
487521004644	NAD binding site [chemical binding]; other site
487521004645	catalytic Zn binding site [ion binding]; other site
487521004646	substrate binding site [chemical binding]; other site
487521004647	structural Zn binding site [ion binding]; other site
487521004648	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521004649	Cytochrome P450; Region: p450; cl12078
487521004650	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521004651	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521004652	substrate binding pocket [chemical binding]; other site
487521004653	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004654	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521004655	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521004656	active site
487521004657	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004658	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004659	active site
487521004660	PAS fold; Region: PAS_4; pfam08448
487521004661	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
487521004662	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
487521004663	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
487521004664	ATP binding site [chemical binding]; other site
487521004665	Mg2+ binding site [ion binding]; other site
487521004666	G-X-G motif; other site
487521004667	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521004668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521004669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521004670	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521004671	CoenzymeA binding site [chemical binding]; other site
487521004672	subunit interaction site [polypeptide binding]; other site
487521004673	PHB binding site; other site
487521004674	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521004675	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521004676	putative AMP binding site [chemical binding]; other site
487521004677	putative active site [active]
487521004678	acyl-activating enzyme (AAE) consensus motif; other site
487521004679	putative CoA binding site [chemical binding]; other site
487521004680	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
487521004681	active site
487521004682	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004683	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004684	active site
487521004685	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004686	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004687	active site
487521004688	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004689	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004690	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521004691	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521004692	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
487521004693	classical (c) SDRs; Region: SDR_c; cd05233
487521004694	NAD(P) binding site [chemical binding]; other site
487521004695	active site
487521004696	Transcriptional regulators [Transcription]; Region: FadR; COG2186
487521004697	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521004698	DNA-binding site [nucleotide binding]; DNA binding site
487521004699	FCD domain; Region: FCD; pfam07729
487521004700	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521004701	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521004702	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521004703	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521004704	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
487521004705	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
487521004706	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521004707	Cytochrome P450; Region: p450; cl12078
487521004708	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521004709	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521004710	[2Fe-2S] cluster binding site [ion binding]; other site
487521004711	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521004712	hydrophobic ligand binding site; other site
487521004713	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
487521004714	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
487521004715	acyl-activating enzyme (AAE) consensus motif; other site
487521004716	putative AMP binding site [chemical binding]; other site
487521004717	putative active site [active]
487521004718	putative CoA binding site [chemical binding]; other site
487521004719	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521004720	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
487521004721	active site
487521004722	catalytic site [active]
487521004723	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
487521004724	putative active site [active]
487521004725	putative catalytic site [active]
487521004726	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
487521004727	TIGR03086 family protein; Region: TIGR03086
487521004728	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
487521004729	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521004730	NAD binding site [chemical binding]; other site
487521004731	catalytic residues [active]
487521004732	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
487521004733	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521004734	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521004735	[2Fe-2S] cluster binding site [ion binding]; other site
487521004736	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
487521004737	putative alpha subunit interface [polypeptide binding]; other site
487521004738	putative active site [active]
487521004739	putative substrate binding site [chemical binding]; other site
487521004740	Fe binding site [ion binding]; other site
487521004741	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521004742	sequence-specific DNA binding site [nucleotide binding]; other site
487521004743	salt bridge; other site
487521004744	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
487521004745	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
487521004746	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
487521004747	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487521004748	phosphate binding site [ion binding]; other site
487521004749	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
487521004750	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
487521004751	putative active site [active]
487521004752	putative catalytic site [active]
487521004753	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
487521004754	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
487521004755	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
487521004756	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
487521004757	putative NAD(P) binding site [chemical binding]; other site
487521004758	active site
487521004759	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
487521004760	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
487521004761	active site
487521004762	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
487521004763	hypothetical protein; Provisional; Region: PRK07907
487521004764	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
487521004765	active site
487521004766	metal binding site [ion binding]; metal-binding site
487521004767	dimer interface [polypeptide binding]; other site
487521004768	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521004769	Cytochrome P450; Region: p450; cl12078
487521004770	MarR family; Region: MarR_2; pfam12802
487521004771	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
487521004772	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487521004773	catalytic triad [active]
487521004774	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
487521004775	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
487521004776	hypothetical protein; Provisional; Region: PRK01346
487521004777	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
487521004778	MMPL family; Region: MMPL; pfam03176
487521004779	MMPL family; Region: MMPL; pfam03176
487521004780	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
487521004781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
487521004782	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
487521004783	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
487521004784	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
487521004785	catalytic site [active]
487521004786	putative active site [active]
487521004787	putative substrate binding site [chemical binding]; other site
487521004788	dimer interface [polypeptide binding]; other site
487521004789	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
487521004790	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487521004791	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521004792	NAD(P) binding site [chemical binding]; other site
487521004793	active site
487521004794	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
487521004795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521004796	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521004797	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521004798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521004799	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
487521004800	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
487521004801	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521004802	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
487521004803	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487521004804	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
487521004805	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
487521004806	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
487521004807	carboxyltransferase (CT) interaction site; other site
487521004808	biotinylation site [posttranslational modification]; other site
487521004809	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521004810	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521004811	active site
487521004812	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
487521004813	putative active site [active]
487521004814	putative catalytic site [active]
487521004815	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
487521004816	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
487521004817	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
487521004818	tetramer interface [polypeptide binding]; other site
487521004819	TPP-binding site [chemical binding]; other site
487521004820	heterodimer interface [polypeptide binding]; other site
487521004821	phosphorylation loop region [posttranslational modification]
487521004822	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
487521004823	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
487521004824	alpha subunit interface [polypeptide binding]; other site
487521004825	TPP binding site [chemical binding]; other site
487521004826	heterodimer interface [polypeptide binding]; other site
487521004827	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
487521004828	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
487521004829	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
487521004830	E3 interaction surface; other site
487521004831	lipoyl attachment site [posttranslational modification]; other site
487521004832	e3 binding domain; Region: E3_binding; pfam02817
487521004833	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
487521004834	enoyl-CoA hydratase; Provisional; Region: PRK05870
487521004835	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521004836	substrate binding site [chemical binding]; other site
487521004837	oxyanion hole (OAH) forming residues; other site
487521004838	trimer interface [polypeptide binding]; other site
487521004839	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
487521004840	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521004841	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521004842	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521004843	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521004844	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
487521004845	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
487521004846	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521004847	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
487521004848	putative acyl-acceptor binding pocket; other site
487521004849	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
487521004850	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
487521004851	putative acyl-acceptor binding pocket; other site
487521004852	Copper resistance protein D; Region: CopD; pfam05425
487521004853	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
487521004854	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
487521004855	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
487521004856	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
487521004857	dimer interface [polypeptide binding]; other site
487521004858	ssDNA binding site [nucleotide binding]; other site
487521004859	tetramer (dimer of dimers) interface [polypeptide binding]; other site
487521004860	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
487521004861	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521004862	Walker A/P-loop; other site
487521004863	ATP binding site [chemical binding]; other site
487521004864	Q-loop/lid; other site
487521004865	ABC transporter signature motif; other site
487521004866	Walker B; other site
487521004867	D-loop; other site
487521004868	H-loop/switch region; other site
487521004869	ABC transporter; Region: ABC_tran_2; pfam12848
487521004870	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487521004871	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
487521004872	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
487521004873	active site
487521004874	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521004875	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
487521004876	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
487521004877	active site
487521004878	catalytic site [active]
487521004879	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
487521004880	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
487521004881	apolar tunnel; other site
487521004882	heme binding site [chemical binding]; other site
487521004883	dimerization interface [polypeptide binding]; other site
487521004884	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
487521004885	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521004886	active site
487521004887	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
487521004888	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
487521004889	Zn binding site [ion binding]; other site
487521004890	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
487521004891	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
487521004892	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
487521004893	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
487521004894	putative DNA binding site [nucleotide binding]; other site
487521004895	catalytic residue [active]
487521004896	putative H2TH interface [polypeptide binding]; other site
487521004897	putative catalytic residues [active]
487521004898	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
487521004899	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
487521004900	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521004901	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521004902	trigger factor; Provisional; Region: tig; PRK01490
487521004903	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
487521004904	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
487521004905	Clp protease; Region: CLP_protease; pfam00574
487521004906	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
487521004907	oligomer interface [polypeptide binding]; other site
487521004908	active site residues [active]
487521004909	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
487521004910	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
487521004911	oligomer interface [polypeptide binding]; other site
487521004912	active site residues [active]
487521004913	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521004914	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521004915	Integrase core domain; Region: rve; pfam00665
487521004916	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
487521004917	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
487521004918	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
487521004919	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
487521004920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521004921	Walker A motif; other site
487521004922	ATP binding site [chemical binding]; other site
487521004923	Walker B motif; other site
487521004924	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
487521004925	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
487521004926	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
487521004927	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
487521004928	dimer interface [polypeptide binding]; other site
487521004929	PYR/PP interface [polypeptide binding]; other site
487521004930	TPP binding site [chemical binding]; other site
487521004931	substrate binding site [chemical binding]; other site
487521004932	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
487521004933	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
487521004934	TPP-binding site [chemical binding]; other site
487521004935	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
487521004936	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
487521004937	GTP binding site; other site
487521004938	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
487521004939	Uncharacterized conserved protein [Function unknown]; Region: COG3268
487521004940	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
487521004941	NAD(P) binding pocket [chemical binding]; other site
487521004942	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
487521004943	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521004944	active site
487521004945	HIGH motif; other site
487521004946	nucleotide binding site [chemical binding]; other site
487521004947	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
487521004948	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
487521004949	active site
487521004950	KMSKS motif; other site
487521004951	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
487521004952	tRNA binding surface [nucleotide binding]; other site
487521004953	anticodon binding site; other site
487521004954	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
487521004955	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
487521004956	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487521004957	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
487521004958	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
487521004959	active site
487521004960	multimer interface [polypeptide binding]; other site
487521004961	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
487521004962	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
487521004963	homodimer interface [polypeptide binding]; other site
487521004964	oligonucleotide binding site [chemical binding]; other site
487521004965	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
487521004966	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
487521004967	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
487521004968	GTPase CgtA; Reviewed; Region: obgE; PRK12296
487521004969	GTP1/OBG; Region: GTP1_OBG; pfam01018
487521004970	Obg GTPase; Region: Obg; cd01898
487521004971	G1 box; other site
487521004972	GTP/Mg2+ binding site [chemical binding]; other site
487521004973	Switch I region; other site
487521004974	G2 box; other site
487521004975	G3 box; other site
487521004976	Switch II region; other site
487521004977	G4 box; other site
487521004978	G5 box; other site
487521004979	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
487521004980	gamma-glutamyl kinase; Provisional; Region: PRK05429
487521004981	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
487521004982	nucleotide binding site [chemical binding]; other site
487521004983	homotetrameric interface [polypeptide binding]; other site
487521004984	putative phosphate binding site [ion binding]; other site
487521004985	putative allosteric binding site; other site
487521004986	PUA domain; Region: PUA; pfam01472
487521004987	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521004988	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521004989	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521004990	Cytochrome P450; Region: p450; cl12078
487521004991	NAD-dependent deacetylase; Provisional; Region: PRK00481
487521004992	SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409
487521004993	NAD+ binding site [chemical binding]; other site
487521004994	substrate binding site [chemical binding]; other site
487521004995	Zn binding site [ion binding]; other site
487521004996	Isochorismatase family; Region: Isochorismatase; pfam00857
487521004997	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
487521004998	catalytic triad [active]
487521004999	conserved cis-peptide bond; other site
487521005000	NAD synthetase; Reviewed; Region: nadE; PRK02628
487521005001	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
487521005002	multimer interface [polypeptide binding]; other site
487521005003	active site
487521005004	catalytic triad [active]
487521005005	protein interface 1 [polypeptide binding]; other site
487521005006	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
487521005007	homodimer interface [polypeptide binding]; other site
487521005008	NAD binding pocket [chemical binding]; other site
487521005009	ATP binding pocket [chemical binding]; other site
487521005010	Mg binding site [ion binding]; other site
487521005011	active-site loop [active]
487521005012	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
487521005013	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
487521005014	substrate binding site [chemical binding]; other site
487521005015	dimer interface [polypeptide binding]; other site
487521005016	ATP binding site [chemical binding]; other site
487521005017	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521005018	dimerization interface [polypeptide binding]; other site
487521005019	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
487521005020	cyclase homology domain; Region: CHD; cd07302
487521005021	nucleotidyl binding site; other site
487521005022	metal binding site [ion binding]; metal-binding site
487521005023	dimer interface [polypeptide binding]; other site
487521005024	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
487521005025	Mechanosensitive ion channel; Region: MS_channel; pfam00924
487521005026	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
487521005027	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
487521005028	ligand binding site [chemical binding]; other site
487521005029	flexible hinge region; other site
487521005030	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
487521005031	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
487521005032	putative catalytic cysteine [active]
487521005033	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
487521005034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521005035	Walker A motif; other site
487521005036	ATP binding site [chemical binding]; other site
487521005037	Walker B motif; other site
487521005038	arginine finger; other site
487521005039	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
487521005040	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
487521005041	metal ion-dependent adhesion site (MIDAS); other site
487521005042	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
487521005043	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
487521005044	active site
487521005045	(T/H)XGH motif; other site
487521005046	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
487521005047	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521005048	catalytic core [active]
487521005049	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
487521005050	active site
487521005051	catalytic triad [active]
487521005052	oxyanion hole [active]
487521005053	EDD domain protein, DegV family; Region: DegV; TIGR00762
487521005054	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
487521005055	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
487521005056	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521005057	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005058	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742
487521005059	acyl-CoA synthetase; Validated; Region: PRK05850
487521005060	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
487521005061	acyl-activating enzyme (AAE) consensus motif; other site
487521005062	active site
487521005063	PE-PPE domain; Region: PE-PPE; pfam08237
487521005064	Transport protein; Region: actII; TIGR00833
487521005065	Condensation domain; Region: Condensation; pfam00668
487521005066	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521005067	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
487521005068	active site
487521005069	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
487521005070	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521005071	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
487521005072	KR domain; Region: KR; pfam08659
487521005073	putative NADP binding site [chemical binding]; other site
487521005074	active site
487521005075	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521005076	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
487521005077	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521005078	active site
487521005079	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521005080	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
487521005081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521005082	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
487521005083	Enoylreductase; Region: PKS_ER; smart00829
487521005084	NAD(P) binding site [chemical binding]; other site
487521005085	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
487521005086	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
487521005087	putative NADP binding site [chemical binding]; other site
487521005088	active site
487521005089	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521005090	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521005091	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
487521005092	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521005093	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521005094	active site
487521005095	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
487521005096	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
487521005097	FAD binding site [chemical binding]; other site
487521005098	substrate binding site [chemical binding]; other site
487521005099	catalytic base [active]
487521005100	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
487521005101	Helix-hairpin-helix motif; Region: HHH; pfam00633
487521005102	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
487521005103	Competence protein; Region: Competence; pfam03772
487521005104	hypothetical protein; Reviewed; Region: PRK07914
487521005105	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
487521005106	Uncharacterized conserved protein [Function unknown]; Region: COG2308
487521005107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
487521005108	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
487521005109	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
487521005110	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
487521005111	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
487521005112	Predicted transcriptional regulators [Transcription]; Region: COG1733
487521005113	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
487521005114	DoxX-like family; Region: DoxX_2; pfam13564
487521005115	ribonuclease Z; Reviewed; Region: PRK00055
487521005116	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
487521005117	FOG: CBS domain [General function prediction only]; Region: COG0517
487521005118	PemK-like protein; Region: PemK; pfam02452
487521005119	GTP-binding protein LepA; Provisional; Region: PRK05433
487521005120	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
487521005121	putative GEF interaction site [polypeptide binding]; other site
487521005122	Switch I region; other site
487521005123	G2 box; other site
487521005124	G3 box; other site
487521005125	Switch II region; other site
487521005126	GTP/Mg2+ binding site [chemical binding]; other site
487521005127	G4 box; other site
487521005128	G5 box; other site
487521005129	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
487521005130	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
487521005131	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
487521005132	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521005133	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521005134	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
487521005135	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
487521005136	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
487521005137	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
487521005138	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
487521005139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521005140	dimer interface [polypeptide binding]; other site
487521005141	conserved gate region; other site
487521005142	putative PBP binding loops; other site
487521005143	ABC-ATPase subunit interface; other site
487521005144	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
487521005145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521005146	dimer interface [polypeptide binding]; other site
487521005147	conserved gate region; other site
487521005148	putative PBP binding loops; other site
487521005149	ABC-ATPase subunit interface; other site
487521005150	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
487521005151	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
487521005152	Walker A/P-loop; other site
487521005153	ATP binding site [chemical binding]; other site
487521005154	Q-loop/lid; other site
487521005155	ABC transporter signature motif; other site
487521005156	Walker B; other site
487521005157	D-loop; other site
487521005158	H-loop/switch region; other site
487521005159	TOBE domain; Region: TOBE; pfam03459
487521005160	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
487521005161	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
487521005162	Active Sites [active]
487521005163	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
487521005164	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
487521005165	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
487521005166	coproporphyrinogen III oxidase; Validated; Region: PRK05628
487521005167	HemN C-terminal domain; Region: HemN_C; pfam06969
487521005168	Predicted permease [General function prediction only]; Region: COG3329
487521005169	salicylate synthase MbtI; Reviewed; Region: PRK07912
487521005170	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
487521005171	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778
487521005172	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487521005173	DNA binding residues [nucleotide binding]
487521005174	putative dimer interface [polypeptide binding]; other site
487521005175	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521005176	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521005177	classical (c) SDRs; Region: SDR_c; cd05233
487521005178	NAD(P) binding site [chemical binding]; other site
487521005179	active site
487521005180	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
487521005181	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
487521005182	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521005183	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521005184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521005185	S-adenosylmethionine binding site [chemical binding]; other site
487521005186	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521005187	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521005188	S-adenosylmethionine binding site [chemical binding]; other site
487521005189	Helix-turn-helix domain; Region: HTH_31; pfam13560
487521005190	salt bridge; other site
487521005191	non-specific DNA binding site [nucleotide binding]; other site
487521005192	sequence-specific DNA binding site [nucleotide binding]; other site
487521005193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521005194	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521005195	S-adenosylmethionine binding site [chemical binding]; other site
487521005196	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
487521005197	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
487521005198	Cupin domain; Region: Cupin_2; pfam07883
487521005199	choline dehydrogenase; Validated; Region: PRK02106
487521005200	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
487521005201	potential frameshift: common BLAST hit: gi|126438197|ref|YP_001073888.1| TetR family transcriptional regulator
487521005202	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005203	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005204	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521005205	lipid-transfer protein; Provisional; Region: PRK07855
487521005206	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521005207	active site
487521005208	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
487521005209	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
487521005210	NAD binding site [chemical binding]; other site
487521005211	catalytic Zn binding site [ion binding]; other site
487521005212	substrate binding site [chemical binding]; other site
487521005213	structural Zn binding site [ion binding]; other site
487521005214	short chain dehydrogenase; Provisional; Region: PRK07775
487521005215	classical (c) SDRs; Region: SDR_c; cd05233
487521005216	NAD(P) binding site [chemical binding]; other site
487521005217	active site
487521005218	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521005219	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005220	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005221	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005222	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
487521005223	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
487521005224	ligand binding site [chemical binding]; other site
487521005225	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005226	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521005227	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005228	Cytochrome P450; Region: p450; cl12078
487521005229	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005230	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521005231	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521005232	NAD(P) binding site [chemical binding]; other site
487521005233	active site
487521005234	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
487521005235	classical (c) SDRs; Region: SDR_c; cd05233
487521005236	NAD(P) binding site [chemical binding]; other site
487521005237	active site
487521005238	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521005239	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005240	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521005241	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005242	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
487521005243	short chain dehydrogenase; Provisional; Region: PRK07814
487521005244	classical (c) SDRs; Region: SDR_c; cd05233
487521005245	NAD(P) binding site [chemical binding]; other site
487521005246	active site
487521005247	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521005248	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521005249	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521005250	acyl-activating enzyme (AAE) consensus motif; other site
487521005251	acyl-activating enzyme (AAE) consensus motif; other site
487521005252	AMP binding site [chemical binding]; other site
487521005253	active site
487521005254	CoA binding site [chemical binding]; other site
487521005255	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521005256	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521005257	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521005258	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005259	Cytochrome P450; Region: p450; cl12078
487521005260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005261	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005262	lipid-transfer protein; Provisional; Region: PRK07855
487521005263	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521005264	active site
487521005265	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
487521005266	putative active site [active]
487521005267	putative catalytic site [active]
487521005268	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005269	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521005270	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521005271	active site
487521005272	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
487521005273	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521005274	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521005275	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
487521005276	active site
487521005277	catalytic site [active]
487521005278	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005279	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005280	active site
487521005281	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005282	Cytochrome P450; Region: p450; cl12078
487521005283	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521005284	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
487521005285	NAD binding site [chemical binding]; other site
487521005286	catalytic residues [active]
487521005287	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521005288	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521005289	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521005290	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521005291	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
487521005292	putative active site [active]
487521005293	putative catalytic site [active]
487521005294	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521005295	Isochorismatase family; Region: Isochorismatase; pfam00857
487521005296	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
487521005297	catalytic triad [active]
487521005298	conserved cis-peptide bond; other site
487521005299	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521005300	SnoaL-like domain; Region: SnoaL_3; pfam13474
487521005301	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521005302	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521005303	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005304	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521005305	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521005306	active site
487521005307	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521005308	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005309	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521005310	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005311	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005312	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005313	active site
487521005314	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
487521005315	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
487521005316	acyl-activating enzyme (AAE) consensus motif; other site
487521005317	putative AMP binding site [chemical binding]; other site
487521005318	putative active site [active]
487521005319	putative CoA binding site [chemical binding]; other site
487521005320	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521005321	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
487521005322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521005323	NAD(P) binding site [chemical binding]; other site
487521005324	active site
487521005325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521005326	active site
487521005327	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521005328	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521005329	acyl-activating enzyme (AAE) consensus motif; other site
487521005330	AMP binding site [chemical binding]; other site
487521005331	active site
487521005332	CoA binding site [chemical binding]; other site
487521005333	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521005334	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521005335	substrate binding site [chemical binding]; other site
487521005336	oxyanion hole (OAH) forming residues; other site
487521005337	trimer interface [polypeptide binding]; other site
487521005338	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521005339	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521005340	substrate binding site [chemical binding]; other site
487521005341	oxyanion hole (OAH) forming residues; other site
487521005342	trimer interface [polypeptide binding]; other site
487521005343	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005344	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005345	active site
487521005346	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521005347	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521005348	substrate binding site [chemical binding]; other site
487521005349	oxyanion hole (OAH) forming residues; other site
487521005350	trimer interface [polypeptide binding]; other site
487521005351	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521005352	active site 2 [active]
487521005353	active site 1 [active]
487521005354	enoyl-CoA hydratase; Provisional; Region: PRK06688
487521005355	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521005356	substrate binding site [chemical binding]; other site
487521005357	oxyanion hole (OAH) forming residues; other site
487521005358	trimer interface [polypeptide binding]; other site
487521005359	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
487521005360	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
487521005361	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
487521005362	NAD binding site [chemical binding]; other site
487521005363	homodimer interface [polypeptide binding]; other site
487521005364	active site
487521005365	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521005366	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521005367	acyl-activating enzyme (AAE) consensus motif; other site
487521005368	AMP binding site [chemical binding]; other site
487521005369	active site
487521005370	CoA binding site [chemical binding]; other site
487521005371	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521005372	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521005373	thiolase; Provisional; Region: PRK06158
487521005374	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521005375	active site
487521005376	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
487521005377	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
487521005378	active site
487521005379	iron coordination sites [ion binding]; other site
487521005380	substrate binding pocket [chemical binding]; other site
487521005381	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
487521005382	glycerate dehydrogenase; Provisional; Region: PRK06487
487521005383	ligand binding site [chemical binding]; other site
487521005384	NAD binding site [chemical binding]; other site
487521005385	dimerization interface [polypeptide binding]; other site
487521005386	catalytic site [active]
487521005387	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521005388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521005389	substrate binding site [chemical binding]; other site
487521005390	oxyanion hole (OAH) forming residues; other site
487521005391	trimer interface [polypeptide binding]; other site
487521005392	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521005393	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005394	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005395	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005396	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005397	active site
487521005398	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521005399	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005400	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005401	active site
487521005402	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521005403	CoenzymeA binding site [chemical binding]; other site
487521005404	subunit interaction site [polypeptide binding]; other site
487521005405	PHB binding site; other site
487521005406	enoyl-CoA hydratase; Provisional; Region: PRK08290
487521005407	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521005408	substrate binding site [chemical binding]; other site
487521005409	oxyanion hole (OAH) forming residues; other site
487521005410	trimer interface [polypeptide binding]; other site
487521005411	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005412	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521005413	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
487521005414	FMN binding site [chemical binding]; other site
487521005415	dimer interface [polypeptide binding]; other site
487521005416	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005417	Cytochrome P450; Region: p450; cl12078
487521005418	Predicted transcriptional regulator [Transcription]; Region: COG2345
487521005419	putative DNA binding site [nucleotide binding]; other site
487521005420	Helix-turn-helix domain; Region: HTH_20; pfam12840
487521005421	dimerization interface [polypeptide binding]; other site
487521005422	putative Zn2+ binding site [ion binding]; other site
487521005423	Hemerythrin-like domain; Region: Hr-like; cd12108
487521005424	Fe binding site [ion binding]; other site
487521005425	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
487521005426	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
487521005427	Hemerythrin-like domain; Region: Hr-like; cd12108
487521005428	Fe binding site [ion binding]; other site
487521005429	OsmC-like protein; Region: OsmC; cl00767
487521005430	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
487521005431	dimer interface [polypeptide binding]; other site
487521005432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521005433	putative DNA binding site [nucleotide binding]; other site
487521005434	dimerization interface [polypeptide binding]; other site
487521005435	Predicted transcriptional regulator [Transcription]; Region: COG2345
487521005436	putative Zn2+ binding site [ion binding]; other site
487521005437	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
487521005438	heme-binding site [chemical binding]; other site
487521005439	Ferredoxin [Energy production and conversion]; Region: COG1146
487521005440	4Fe-4S binding domain; Region: Fer4; pfam00037
487521005441	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
487521005442	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
487521005443	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
487521005444	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521005445	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
487521005446	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
487521005447	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
487521005448	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
487521005449	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
487521005450	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
487521005451	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
487521005452	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
487521005453	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
487521005454	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
487521005455	Binuclear center (active site) [active]
487521005456	K-pathway; other site
487521005457	Putative proton exit pathway; other site
487521005458	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
487521005459	Fe binding site [ion binding]; other site
487521005460	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521005461	PPE family; Region: PPE; pfam00823
487521005462	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521005463	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
487521005464	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487521005465	Condensation domain; Region: Condensation; pfam00668
487521005466	malate dehydrogenase; Provisional; Region: PRK13529
487521005467	Malic enzyme, N-terminal domain; Region: malic; pfam00390
487521005468	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
487521005469	NAD(P) binding site [chemical binding]; other site
487521005470	Flavodoxin; Region: Flavodoxin_1; pfam00258
487521005471	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
487521005472	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
487521005473	FAD binding pocket [chemical binding]; other site
487521005474	FAD binding motif [chemical binding]; other site
487521005475	catalytic residues [active]
487521005476	NAD binding pocket [chemical binding]; other site
487521005477	phosphate binding motif [ion binding]; other site
487521005478	beta-alpha-beta structure motif; other site
487521005479	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
487521005480	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
487521005481	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005482	Cupin domain; Region: Cupin_2; cl17218
487521005483	short chain dehydrogenase; Provisional; Region: PRK07577
487521005484	classical (c) SDRs; Region: SDR_c; cd05233
487521005485	NAD(P) binding site [chemical binding]; other site
487521005486	active site
487521005487	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487521005488	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521005489	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
487521005490	dimerization interface [polypeptide binding]; other site
487521005491	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
487521005492	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
487521005493	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
487521005494	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
487521005495	acyl-activating enzyme (AAE) consensus motif; other site
487521005496	active site
487521005497	AMP binding site [chemical binding]; other site
487521005498	substrate binding site [chemical binding]; other site
487521005499	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
487521005500	Condensation domain; Region: Condensation; pfam00668
487521005501	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521005502	Nonribosomal peptide synthase; Region: NRPS; pfam08415
487521005503	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
487521005504	acyl-activating enzyme (AAE) consensus motif; other site
487521005505	AMP binding site [chemical binding]; other site
487521005506	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521005507	Thioesterase domain; Region: Thioesterase; pfam00975
487521005508	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521005509	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
487521005510	active site
487521005511	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
487521005512	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521005513	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
487521005514	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
487521005515	NADP binding site [chemical binding]; other site
487521005516	active site
487521005517	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521005518	Condensation domain; Region: Condensation; pfam00668
487521005519	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521005520	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521005521	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521005522	acyl-activating enzyme (AAE) consensus motif; other site
487521005523	AMP binding site [chemical binding]; other site
487521005524	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521005525	Condensation domain; Region: Condensation; pfam00668
487521005526	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521005527	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521005528	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521005529	acyl-activating enzyme (AAE) consensus motif; other site
487521005530	AMP binding site [chemical binding]; other site
487521005531	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521005532	Condensation domain; Region: Condensation; pfam00668
487521005533	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521005534	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521005535	acyl-activating enzyme (AAE) consensus motif; other site
487521005536	AMP binding site [chemical binding]; other site
487521005537	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521005538	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
487521005539	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521005540	MbtH-like protein; Region: MbtH; pfam03621
487521005541	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
487521005542	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
487521005543	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521005544	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521005545	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521005546	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
487521005547	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
487521005548	HTH domain; Region: HTH_11; cl17392
487521005549	chaperone protein DnaJ; Provisional; Region: PRK14278
487521005550	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
487521005551	HSP70 interaction site [polypeptide binding]; other site
487521005552	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
487521005553	Zn binding sites [ion binding]; other site
487521005554	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
487521005555	dimer interface [polypeptide binding]; other site
487521005556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
487521005557	RNA methyltransferase, RsmE family; Region: TIGR00046
487521005558	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
487521005559	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
487521005560	PhoH-like protein; Region: PhoH; pfam02562
487521005561	metal-binding heat shock protein; Provisional; Region: PRK00016
487521005562	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
487521005563	Domain of unknown function DUF21; Region: DUF21; pfam01595
487521005564	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
487521005565	Transporter associated domain; Region: CorC_HlyC; smart01091
487521005566	GTPase Era; Reviewed; Region: era; PRK00089
487521005567	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
487521005568	G1 box; other site
487521005569	GTP/Mg2+ binding site [chemical binding]; other site
487521005570	Switch I region; other site
487521005571	G2 box; other site
487521005572	Switch II region; other site
487521005573	G3 box; other site
487521005574	G4 box; other site
487521005575	G5 box; other site
487521005576	KH domain; Region: KH_2; pfam07650
487521005577	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
487521005578	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521005579	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521005580	catalytic residue [active]
487521005581	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
487521005582	amidase; Provisional; Region: PRK06061
487521005583	Amidase; Region: Amidase; pfam01425
487521005584	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
487521005585	Recombination protein O N terminal; Region: RecO_N; pfam11967
487521005586	Recombination protein O C terminal; Region: RecO_C; pfam02565
487521005587	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
487521005588	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
487521005589	catalytic residue [active]
487521005590	putative FPP diphosphate  binding site; other site
487521005591	putative FPP binding hydrophobic cleft; other site
487521005592	dimer interface [polypeptide binding]; other site
487521005593	putative IPP diphosphate binding site; other site
487521005594	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
487521005595	metal binding site 2 [ion binding]; metal-binding site
487521005596	putative DNA binding helix; other site
487521005597	metal binding site 1 [ion binding]; metal-binding site
487521005598	dimer interface [polypeptide binding]; other site
487521005599	structural Zn2+ binding site [ion binding]; other site
487521005600	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521005601	dimerization interface [polypeptide binding]; other site
487521005602	putative DNA binding site [nucleotide binding]; other site
487521005603	putative Zn2+ binding site [ion binding]; other site
487521005604	glycyl-tRNA synthetase; Provisional; Region: PRK04173
487521005605	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
487521005606	motif 1; other site
487521005607	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
487521005608	active site
487521005609	motif 2; other site
487521005610	motif 3; other site
487521005611	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
487521005612	anticodon binding site; other site
487521005613	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521005614	PPE family; Region: PPE; pfam00823
487521005615	Repair protein; Region: Repair_PSII; pfam04536
487521005616	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
487521005617	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
487521005618	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
487521005619	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
487521005620	E-class dimer interface [polypeptide binding]; other site
487521005621	P-class dimer interface [polypeptide binding]; other site
487521005622	active site
487521005623	Cu2+ binding site [ion binding]; other site
487521005624	Zn2+ binding site [ion binding]; other site
487521005625	DNA primase; Validated; Region: dnaG; PRK05667
487521005626	CHC2 zinc finger; Region: zf-CHC2; cl17510
487521005627	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
487521005628	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
487521005629	active site
487521005630	metal binding site [ion binding]; metal-binding site
487521005631	interdomain interaction site; other site
487521005632	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
487521005633	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
487521005634	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
487521005635	active site
487521005636	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
487521005637	non-prolyl cis peptide bond; other site
487521005638	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
487521005639	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
487521005640	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521005641	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521005642	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
487521005643	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
487521005644	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
487521005645	trimer interface [polypeptide binding]; other site
487521005646	active site
487521005647	substrate binding site [chemical binding]; other site
487521005648	CoA binding site [chemical binding]; other site
487521005649	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
487521005650	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
487521005651	dimer interface [polypeptide binding]; other site
487521005652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521005653	catalytic residue [active]
487521005654	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
487521005655	Stf0 sulphotransferase; Region: Sulphotransf; pfam09037
487521005656	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
487521005657	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
487521005658	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
487521005659	[4Fe-4S] binding site [ion binding]; other site
487521005660	molybdopterin cofactor binding site; other site
487521005661	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
487521005662	molybdopterin cofactor binding site; other site
487521005663	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
487521005664	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
487521005665	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
487521005666	FAD binding pocket [chemical binding]; other site
487521005667	FAD binding motif [chemical binding]; other site
487521005668	catalytic residues [active]
487521005669	NAD binding pocket [chemical binding]; other site
487521005670	phosphate binding motif [ion binding]; other site
487521005671	beta-alpha-beta structure motif; other site
487521005672	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
487521005673	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005674	active site
487521005675	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521005676	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
487521005677	Walker A/P-loop; other site
487521005678	ATP binding site [chemical binding]; other site
487521005679	Q-loop/lid; other site
487521005680	ABC transporter signature motif; other site
487521005681	Walker B; other site
487521005682	D-loop; other site
487521005683	H-loop/switch region; other site
487521005684	MarR family; Region: MarR; pfam01047
487521005685	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521005686	PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758
487521005687	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644
487521005688	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
487521005689	Walker A/P-loop; other site
487521005690	ATP binding site [chemical binding]; other site
487521005691	Q-loop/lid; other site
487521005692	ABC transporter signature motif; other site
487521005693	Walker B; other site
487521005694	D-loop; other site
487521005695	H-loop/switch region; other site
487521005696	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487521005697	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
487521005698	Walker A/P-loop; other site
487521005699	ATP binding site [chemical binding]; other site
487521005700	Q-loop/lid; other site
487521005701	ABC transporter signature motif; other site
487521005702	Walker B; other site
487521005703	D-loop; other site
487521005704	H-loop/switch region; other site
487521005705	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
487521005706	amino acid transporter; Region: 2A0306; TIGR00909
487521005707	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
487521005708	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487521005709	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487521005710	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487521005711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521005712	dimer interface [polypeptide binding]; other site
487521005713	conserved gate region; other site
487521005714	putative PBP binding loops; other site
487521005715	ABC-ATPase subunit interface; other site
487521005716	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
487521005717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521005718	dimer interface [polypeptide binding]; other site
487521005719	conserved gate region; other site
487521005720	putative PBP binding loops; other site
487521005721	ABC-ATPase subunit interface; other site
487521005722	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
487521005723	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
487521005724	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521005725	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
487521005726	polymerase nucleotide-binding site; other site
487521005727	DNA-binding residues [nucleotide binding]; DNA binding site
487521005728	nucleotide binding site [chemical binding]; other site
487521005729	primase nucleotide-binding site [nucleotide binding]; other site
487521005730	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
487521005731	AAA domain; Region: AAA_25; pfam13481
487521005732	Walker B motif; other site
487521005733	multiple promoter invertase; Provisional; Region: mpi; PRK13413
487521005734	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
487521005735	catalytic residues [active]
487521005736	catalytic nucleophile [active]
487521005737	Recombinase; Region: Recombinase; pfam07508
487521005738	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521005739	active site
487521005740	DNA binding site [nucleotide binding]
487521005741	Int/Topo IB signature motif; other site
487521005742	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521005743	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
487521005744	catalytic site [active]
487521005745	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
487521005746	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
487521005747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521005748	ABC transporter signature motif; other site
487521005749	Walker B; other site
487521005750	D-loop; other site
487521005751	H-loop/switch region; other site
487521005752	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
487521005753	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
487521005754	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521005755	NAD(P) binding site [chemical binding]; other site
487521005756	catalytic residues [active]
487521005757	Repair protein; Region: Repair_PSII; pfam04536
487521005758	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
487521005759	AAA domain; Region: AAA_33; pfam13671
487521005760	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
487521005761	active site
487521005762	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
487521005763	catalytic triad [active]
487521005764	active site nucleophile [active]
487521005765	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
487521005766	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
487521005767	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521005768	cyclase homology domain; Region: CHD; cd07302
487521005769	nucleotidyl binding site; other site
487521005770	metal binding site [ion binding]; metal-binding site
487521005771	dimer interface [polypeptide binding]; other site
487521005772	AAA ATPase domain; Region: AAA_16; pfam13191
487521005773	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
487521005774	GAF domain; Region: GAF; pfam01590
487521005775	GAF domain; Region: GAF_3; pfam13492
487521005776	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
487521005777	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
487521005778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
487521005779	ATP binding site [chemical binding]; other site
487521005780	Mg2+ binding site [ion binding]; other site
487521005781	G-X-G motif; other site
487521005782	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521005783	anti sigma factor interaction site; other site
487521005784	regulatory phosphorylation site [posttranslational modification]; other site
487521005785	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521005786	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521005787	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521005788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521005789	S-adenosylmethionine binding site [chemical binding]; other site
487521005790	CCC1-related family of proteins; Region: CCC1_like; cl00278
487521005791	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487521005792	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521005793	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
487521005794	acyl-activating enzyme (AAE) consensus motif; other site
487521005795	putative AMP binding site [chemical binding]; other site
487521005796	putative active site [active]
487521005797	putative CoA binding site [chemical binding]; other site
487521005798	TIGR03085 family protein; Region: TIGR03085
487521005799	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
487521005800	heat shock protein 90; Provisional; Region: PRK05218
487521005801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521005802	ATP binding site [chemical binding]; other site
487521005803	Mg2+ binding site [ion binding]; other site
487521005804	G-X-G motif; other site
487521005805	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521005806	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521005807	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521005808	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
487521005809	dimer interface [polypeptide binding]; other site
487521005810	ligand binding site [chemical binding]; other site
487521005811	Predicted membrane protein [Function unknown]; Region: COG4270
487521005812	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
487521005813	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
487521005814	NAD binding site [chemical binding]; other site
487521005815	catalytic Zn binding site [ion binding]; other site
487521005816	substrate binding site [chemical binding]; other site
487521005817	structural Zn binding site [ion binding]; other site
487521005818	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521005819	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
487521005820	dimer interface [polypeptide binding]; other site
487521005821	active site
487521005822	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
487521005823	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
487521005824	active site
487521005825	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
487521005826	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
487521005827	Multicopper oxidase; Region: Cu-oxidase; pfam00394
487521005828	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
487521005829	DoxX-like family; Region: DoxX_2; pfam13564
487521005830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521005831	NADH(P)-binding; Region: NAD_binding_10; pfam13460
487521005832	NAD(P) binding site [chemical binding]; other site
487521005833	active site
487521005834	haloalkane dehalogenase; Provisional; Region: PRK00870
487521005835	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
487521005836	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
487521005837	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521005838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521005839	homodimer interface [polypeptide binding]; other site
487521005840	catalytic residue [active]
487521005841	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005842	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521005843	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005844	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521005845	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
487521005846	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
487521005847	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
487521005848	ligand binding site [chemical binding]; other site
487521005849	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005850	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005851	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005852	Cytochrome P450; Region: p450; cl12078
487521005853	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521005854	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521005855	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521005856	dimerization interface [polypeptide binding]; other site
487521005857	putative DNA binding site [nucleotide binding]; other site
487521005858	putative Zn2+ binding site [ion binding]; other site
487521005859	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
487521005860	arsenical-resistance protein; Region: acr3; TIGR00832
487521005861	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
487521005862	Low molecular weight phosphatase family; Region: LMWPc; cd00115
487521005863	active site
487521005864	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
487521005865	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521005866	putative metal binding site [ion binding]; other site
487521005867	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
487521005868	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521005869	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005870	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005871	Cytochrome P450; Region: p450; cl12078
487521005872	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
487521005873	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
487521005874	active site residue [active]
487521005875	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
487521005876	active site residue [active]
487521005877	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521005878	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
487521005879	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
487521005880	hypothetical protein; Provisional; Region: PRK08244
487521005881	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521005882	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521005883	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521005884	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005885	Predicted ATPase [General function prediction only]; Region: COG4637
487521005886	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521005887	Walker A/P-loop; other site
487521005888	ATP binding site [chemical binding]; other site
487521005889	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
487521005890	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
487521005891	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
487521005892	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521005893	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521005894	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
487521005895	4Fe-4S binding domain; Region: Fer4; cl02805
487521005896	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487521005897	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521005898	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
487521005899	dimerization interface [polypeptide binding]; other site
487521005900	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
487521005901	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
487521005902	putative active site [active]
487521005903	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
487521005904	putative active site [active]
487521005905	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
487521005906	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
487521005907	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
487521005908	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
487521005909	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521005910	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521005911	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005912	Cytochrome P450; Region: p450; cl12078
487521005913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005915	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005916	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005917	Domain of unknown function (DUF385); Region: DUF385; cl04387
487521005918	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521005919	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
487521005920	FAD binding domain; Region: FAD_binding_4; pfam01565
487521005921	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
487521005922	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521005923	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521005924	active site
487521005925	ATP binding site [chemical binding]; other site
487521005926	substrate binding site [chemical binding]; other site
487521005927	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
487521005928	activation loop (A-loop); other site
487521005929	activation loop (A-loop); other site
487521005930	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
487521005931	2TM domain; Region: 2TM; pfam13239
487521005932	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005933	WHG domain; Region: WHG; pfam13305
487521005934	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005935	Cytochrome P450; Region: p450; cl12078
487521005936	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521005937	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521005938	active site
487521005939	metal binding site [ion binding]; metal-binding site
487521005940	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
487521005941	oligomeric interface; other site
487521005942	putative active site [active]
487521005943	homodimer interface [polypeptide binding]; other site
487521005944	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
487521005945	PLD-like domain; Region: PLDc_2; pfam13091
487521005946	putative homodimer interface [polypeptide binding]; other site
487521005947	putative active site [active]
487521005948	catalytic site [active]
487521005949	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
487521005950	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
487521005951	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521005952	nucleotide binding region [chemical binding]; other site
487521005953	ATP-binding site [chemical binding]; other site
487521005954	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
487521005955	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521005956	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521005957	active site
487521005958	ATP binding site [chemical binding]; other site
487521005959	substrate binding site [chemical binding]; other site
487521005960	activation loop (A-loop); other site
487521005961	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521005962	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521005963	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521005964	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521005965	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521005966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521005967	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521005968	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521005969	active site
487521005970	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
487521005971	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
487521005972	active site
487521005973	metal binding site [ion binding]; metal-binding site
487521005974	Cutinase; Region: Cutinase; pfam01083
487521005975	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521005976	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521005977	Septum formation; Region: Septum_form; pfam13845
487521005978	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521005979	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521005980	Cytochrome P450; Region: p450; cl12078
487521005981	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521005982	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521005983	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521005984	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521005985	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
487521005986	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521005987	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
487521005988	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
487521005989	NAD binding site [chemical binding]; other site
487521005990	catalytic Zn binding site [ion binding]; other site
487521005991	substrate binding site [chemical binding]; other site
487521005992	structural Zn binding site [ion binding]; other site
487521005993	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521005994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521005995	S-adenosylmethionine binding site [chemical binding]; other site
487521005996	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521005997	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521005998	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
487521005999	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521006000	diacylglycerol kinase; Reviewed; Region: PRK11914
487521006001	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
487521006002	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
487521006003	FAD binding domain; Region: FAD_binding_4; pfam01565
487521006004	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521006005	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521006006	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
487521006007	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
487521006008	nucleoside/Zn binding site; other site
487521006009	dimer interface [polypeptide binding]; other site
487521006010	catalytic motif [active]
487521006011	FAD binding domain; Region: FAD_binding_3; pfam01494
487521006012	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
487521006013	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
487521006014	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521006015	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
487521006016	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
487521006017	dimer interface [polypeptide binding]; other site
487521006018	active site
487521006019	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
487521006020	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
487521006021	dimer interface [polypeptide binding]; other site
487521006022	active site
487521006023	acyl carrier protein; Provisional; Region: acpP; PRK00982
487521006024	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
487521006025	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
487521006026	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
487521006027	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
487521006028	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
487521006029	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
487521006030	dimer interface [polypeptide binding]; other site
487521006031	TPP-binding site [chemical binding]; other site
487521006032	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
487521006033	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
487521006034	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
487521006035	dimer interface [polypeptide binding]; other site
487521006036	catalytic triad [active]
487521006037	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
487521006038	Epoxide hydrolase N terminus; Region: EHN; pfam06441
487521006039	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521006040	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487521006041	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521006042	active site
487521006043	metal binding site [ion binding]; metal-binding site
487521006044	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
487521006045	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
487521006046	Low molecular weight phosphatase family; Region: LMWPc; cd00115
487521006047	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
487521006048	active site
487521006049	phosphoglycolate phosphatase; Provisional; Region: PRK13222
487521006050	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521006051	motif II; other site
487521006052	hypothetical protein; Provisional; Region: PRK07908
487521006053	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521006054	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521006055	catalytic residue [active]
487521006056	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
487521006057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
487521006058	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
487521006059	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
487521006060	Putative zinc ribbon domain; Region: DUF164; pfam02591
487521006061	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
487521006062	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
487521006063	RNA/DNA hybrid binding site [nucleotide binding]; other site
487521006064	active site
487521006065	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521006066	catalytic core [active]
487521006067	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
487521006068	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521006069	Helix-turn-helix domain; Region: HTH_18; pfam12833
487521006070	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487521006071	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521006072	sequence-specific DNA binding site [nucleotide binding]; other site
487521006073	salt bridge; other site
487521006074	Cupin domain; Region: Cupin_2; pfam07883
487521006075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521006076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521006077	S-adenosylmethionine binding site [chemical binding]; other site
487521006078	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
487521006079	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
487521006080	putative active site; other site
487521006081	putative metal binding residues [ion binding]; other site
487521006082	signature motif; other site
487521006083	putative triphosphate binding site [ion binding]; other site
487521006084	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
487521006085	hypothetical protein; Provisional; Region: PRK06185
487521006086	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
487521006087	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
487521006088	oligomerization interface [polypeptide binding]; other site
487521006089	active site
487521006090	metal binding site [ion binding]; metal-binding site
487521006091	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
487521006092	TAP-like protein; Region: Abhydrolase_4; pfam08386
487521006093	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
487521006094	TAP-like protein; Region: Abhydrolase_4; pfam08386
487521006095	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
487521006096	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
487521006097	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
487521006098	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
487521006099	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
487521006100	metal binding triad; other site
487521006101	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
487521006102	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
487521006103	metal binding triad; other site
487521006104	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
487521006105	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521006106	CoenzymeA binding site [chemical binding]; other site
487521006107	subunit interaction site [polypeptide binding]; other site
487521006108	PHB binding site; other site
487521006109	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521006110	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521006111	MarR family; Region: MarR_2; pfam12802
487521006112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006113	NADH(P)-binding; Region: NAD_binding_10; pfam13460
487521006114	NAD(P) binding site [chemical binding]; other site
487521006115	active site
487521006116	glutamine synthetase, type I; Region: GlnA; TIGR00653
487521006117	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
487521006118	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
487521006119	RDD family; Region: RDD; pfam06271
487521006120	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
487521006121	lipoyl synthase; Provisional; Region: PRK05481
487521006122	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521006123	FeS/SAM binding site; other site
487521006124	lipoate-protein ligase B; Provisional; Region: PRK14345
487521006125	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
487521006126	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
487521006127	putative NAD(P) binding site [chemical binding]; other site
487521006128	putative active site [active]
487521006129	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
487521006130	E3 interaction surface; other site
487521006131	lipoyl attachment site [posttranslational modification]; other site
487521006132	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
487521006133	E3 interaction surface; other site
487521006134	lipoyl attachment site [posttranslational modification]; other site
487521006135	e3 binding domain; Region: E3_binding; pfam02817
487521006136	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
487521006137	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
487521006138	short chain dehydrogenase; Validated; Region: PRK05855
487521006139	classical (c) SDRs; Region: SDR_c; cd05233
487521006140	NAD(P) binding site [chemical binding]; other site
487521006141	active site
487521006142	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521006143	hydrophobic ligand binding site; other site
487521006144	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
487521006145	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521006146	multifunctional aminopeptidase A; Provisional; Region: PRK00913
487521006147	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
487521006148	interface (dimer of trimers) [polypeptide binding]; other site
487521006149	Substrate-binding/catalytic site; other site
487521006150	Zn-binding sites [ion binding]; other site
487521006151	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
487521006152	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
487521006153	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
487521006154	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
487521006155	homodimer interface [polypeptide binding]; other site
487521006156	substrate-cofactor binding pocket; other site
487521006157	catalytic residue [active]
487521006158	cobalamin synthase; Reviewed; Region: cobS; PRK00235
487521006159	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
487521006160	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
487521006161	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
487521006162	putative dimer interface [polypeptide binding]; other site
487521006163	active site pocket [active]
487521006164	putative cataytic base [active]
487521006165	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
487521006166	homotrimer interface [polypeptide binding]; other site
487521006167	Walker A motif; other site
487521006168	GTP binding site [chemical binding]; other site
487521006169	Walker B motif; other site
487521006170	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
487521006171	Glycerate kinase family; Region: Gly_kinase; pfam02595
487521006172	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
487521006173	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
487521006174	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
487521006175	substrate binding site [chemical binding]; other site
487521006176	ATP binding site [chemical binding]; other site
487521006177	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521006178	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521006179	Integrase core domain; Region: rve; pfam00665
487521006180	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
487521006181	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
487521006182	active site
487521006183	dimer interface [polypeptide binding]; other site
487521006184	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
487521006185	Ligand Binding Site [chemical binding]; other site
487521006186	Molecular Tunnel; other site
487521006187	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
487521006188	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
487521006189	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
487521006190	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521006191	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
487521006192	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
487521006193	heme bH binding site [chemical binding]; other site
487521006194	intrachain domain interface; other site
487521006195	heme bL binding site [chemical binding]; other site
487521006196	interchain domain interface [polypeptide binding]; other site
487521006197	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
487521006198	Qo binding site; other site
487521006199	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
487521006200	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
487521006201	iron-sulfur cluster [ion binding]; other site
487521006202	[2Fe-2S] cluster binding site [ion binding]; other site
487521006203	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
487521006204	Cytochrome c; Region: Cytochrom_C; pfam00034
487521006205	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
487521006206	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
487521006207	Subunit I/III interface [polypeptide binding]; other site
487521006208	hypothetical protein; Validated; Region: PRK07883
487521006209	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
487521006210	active site
487521006211	catalytic site [active]
487521006212	substrate binding site [chemical binding]; other site
487521006213	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
487521006214	GIY-YIG motif/motif A; other site
487521006215	active site
487521006216	catalytic site [active]
487521006217	putative DNA binding site [nucleotide binding]; other site
487521006218	metal binding site [ion binding]; metal-binding site
487521006219	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
487521006220	NlpC/P60 family; Region: NLPC_P60; pfam00877
487521006221	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
487521006222	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521006223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521006224	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
487521006225	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
487521006226	acyl-activating enzyme (AAE) consensus motif; other site
487521006227	putative AMP binding site [chemical binding]; other site
487521006228	putative active site [active]
487521006229	putative CoA binding site [chemical binding]; other site
487521006230	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
487521006231	putative hydrophobic ligand binding site [chemical binding]; other site
487521006232	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
487521006233	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
487521006234	DTAP/Switch II; other site
487521006235	Switch I; other site
487521006236	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521006237	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
487521006238	putative acyl-acceptor binding pocket; other site
487521006239	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
487521006240	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
487521006241	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521006242	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521006243	active site
487521006244	ATP binding site [chemical binding]; other site
487521006245	substrate binding site [chemical binding]; other site
487521006246	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
487521006247	substrate binding site [chemical binding]; other site
487521006248	activation loop (A-loop); other site
487521006249	activation loop (A-loop); other site
487521006250	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
487521006251	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
487521006252	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
487521006253	substrate binding pocket [chemical binding]; other site
487521006254	chain length determination region; other site
487521006255	substrate-Mg2+ binding site; other site
487521006256	catalytic residues [active]
487521006257	aspartate-rich region 1; other site
487521006258	active site lid residues [active]
487521006259	aspartate-rich region 2; other site
487521006260	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
487521006261	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
487521006262	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
487521006263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
487521006264	MraZ protein; Region: MraZ; pfam02381
487521006265	MraZ protein; Region: MraZ; pfam02381
487521006266	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
487521006267	MraW methylase family; Region: Methyltransf_5; cl17771
487521006268	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
487521006269	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
487521006270	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
487521006271	hypothetical protein; Provisional; Region: PRK07236
487521006272	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521006273	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521006274	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
487521006275	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
487521006276	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487521006277	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487521006278	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
487521006279	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487521006280	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487521006281	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
487521006282	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
487521006283	Mg++ binding site [ion binding]; other site
487521006284	putative catalytic motif [active]
487521006285	putative substrate binding site [chemical binding]; other site
487521006286	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
487521006287	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487521006288	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487521006289	cell division protein FtsW; Region: ftsW; TIGR02614
487521006290	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
487521006291	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
487521006292	active site
487521006293	homodimer interface [polypeptide binding]; other site
487521006294	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
487521006295	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
487521006296	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487521006297	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487521006298	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
487521006299	Cell division protein FtsQ; Region: FtsQ; pfam03799
487521006300	cell division protein FtsZ; Validated; Region: PRK09330
487521006301	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
487521006302	nucleotide binding site [chemical binding]; other site
487521006303	SulA interaction site; other site
487521006304	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
487521006305	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
487521006306	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
487521006307	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487521006308	catalytic residue [active]
487521006309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
487521006310	Predicted integral membrane protein [Function unknown]; Region: COG0762
487521006311	DivIVA domain; Region: DivI1A_domain; TIGR03544
487521006312	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
487521006313	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
487521006314	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521006315	active site
487521006316	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
487521006317	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487521006318	DNA binding residues [nucleotide binding]
487521006319	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521006320	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
487521006321	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521006322	Soluble P-type ATPase [General function prediction only]; Region: COG4087
487521006323	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
487521006324	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
487521006325	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
487521006326	MgtE intracellular N domain; Region: MgtE_N; smart00924
487521006327	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
487521006328	Cation efflux family; Region: Cation_efflux; cl00316
487521006329	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
487521006330	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521006331	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521006332	motif II; other site
487521006333	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
487521006334	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521006335	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
487521006336	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
487521006337	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
487521006338	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521006339	dimerization interface [polypeptide binding]; other site
487521006340	putative DNA binding site [nucleotide binding]; other site
487521006341	putative Zn2+ binding site [ion binding]; other site
487521006342	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
487521006343	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521006344	Soluble P-type ATPase [General function prediction only]; Region: COG4087
487521006345	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
487521006346	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
487521006347	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
487521006348	nudix motif; other site
487521006349	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521006350	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
487521006351	hypothetical protein; Provisional; Region: PRK07906
487521006352	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
487521006353	putative metal binding site [ion binding]; other site
487521006354	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
487521006355	substrate binding site [chemical binding]; other site
487521006356	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
487521006357	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
487521006358	quinone interaction residues [chemical binding]; other site
487521006359	active site
487521006360	catalytic residues [active]
487521006361	FMN binding site [chemical binding]; other site
487521006362	substrate binding site [chemical binding]; other site
487521006363	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521006364	catalytic core [active]
487521006365	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
487521006366	conserved hypothetical protein; Region: TIGR03843
487521006367	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
487521006368	active site
487521006369	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
487521006370	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521006371	active site
487521006372	HIGH motif; other site
487521006373	nucleotide binding site [chemical binding]; other site
487521006374	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521006375	active site
487521006376	KMSKS motif; other site
487521006377	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
487521006378	putative tRNA binding surface [nucleotide binding]; other site
487521006379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521006380	Walker A/P-loop; other site
487521006381	ATP binding site [chemical binding]; other site
487521006382	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521006383	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521006384	DNA binding residues [nucleotide binding]
487521006385	dimerization interface [polypeptide binding]; other site
487521006386	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521006387	Walker A/P-loop; other site
487521006388	ATP binding site [chemical binding]; other site
487521006389	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521006390	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521006391	DNA binding residues [nucleotide binding]
487521006392	dimerization interface [polypeptide binding]; other site
487521006393	MbtH-like protein; Region: MbtH; pfam03621
487521006394	Condensation domain; Region: Condensation; pfam00668
487521006395	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521006396	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521006397	acyl-activating enzyme (AAE) consensus motif; other site
487521006398	AMP binding site [chemical binding]; other site
487521006399	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521006400	Condensation domain; Region: Condensation; pfam00668
487521006401	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521006402	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521006403	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521006404	acyl-activating enzyme (AAE) consensus motif; other site
487521006405	AMP binding site [chemical binding]; other site
487521006406	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521006407	Condensation domain; Region: Condensation; pfam00668
487521006408	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521006409	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521006410	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521006411	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521006412	acyl-activating enzyme (AAE) consensus motif; other site
487521006413	AMP binding site [chemical binding]; other site
487521006414	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521006415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521006416	S-adenosylmethionine binding site [chemical binding]; other site
487521006417	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521006418	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521006419	Condensation domain; Region: Condensation; pfam00668
487521006420	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521006421	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521006422	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521006423	acyl-activating enzyme (AAE) consensus motif; other site
487521006424	AMP binding site [chemical binding]; other site
487521006425	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521006426	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
487521006427	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521006428	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521006429	acyl-activating enzyme (AAE) consensus motif; other site
487521006430	AMP binding site [chemical binding]; other site
487521006431	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521006432	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521006433	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
487521006434	putative substrate translocation pore; other site
487521006435	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
487521006436	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521006437	active site
487521006438	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
487521006439	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
487521006440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006441	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
487521006442	Enoylreductase; Region: PKS_ER; smart00829
487521006443	NAD(P) binding site [chemical binding]; other site
487521006444	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
487521006445	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
487521006446	putative NADP binding site [chemical binding]; other site
487521006447	active site
487521006448	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521006449	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521006450	Cytochrome P450; Region: p450; cl12078
487521006451	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
487521006452	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
487521006453	FAD binding pocket [chemical binding]; other site
487521006454	FAD binding motif [chemical binding]; other site
487521006455	phosphate binding motif [ion binding]; other site
487521006456	NAD binding pocket [chemical binding]; other site
487521006457	acyl-CoA synthetase; Validated; Region: PRK05850
487521006458	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
487521006459	acyl-activating enzyme (AAE) consensus motif; other site
487521006460	active site
487521006461	short chain dehydrogenase; Provisional; Region: PRK05872
487521006462	classical (c) SDRs; Region: SDR_c; cd05233
487521006463	NAD(P) binding site [chemical binding]; other site
487521006464	active site
487521006465	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
487521006466	PAC2 family; Region: PAC2; pfam09754
487521006467	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
487521006468	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
487521006469	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
487521006470	substrate binding pocket [chemical binding]; other site
487521006471	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
487521006472	B12 binding site [chemical binding]; other site
487521006473	cobalt ligand [ion binding]; other site
487521006474	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
487521006475	Mannan-binding protein; Region: MVL; pfam12151
487521006476	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
487521006477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
487521006478	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521006479	mce related protein; Region: MCE; pfam02470
487521006480	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521006481	mce related protein; Region: MCE; pfam02470
487521006482	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521006483	mce related protein; Region: MCE; pfam02470
487521006484	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
487521006485	mce related protein; Region: MCE; pfam02470
487521006486	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
487521006487	mce related protein; Region: MCE; pfam02470
487521006488	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
487521006489	mce related protein; Region: MCE; pfam02470
487521006490	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521006491	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521006492	Permease; Region: Permease; pfam02405
487521006493	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521006494	Permease; Region: Permease; pfam02405
487521006495	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521006496	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521006497	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
487521006498	homodimer interface [polypeptide binding]; other site
487521006499	putative metal binding site [ion binding]; other site
487521006500	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
487521006501	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
487521006502	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
487521006503	Predicted membrane protein [Function unknown]; Region: COG3918
487521006504	mercuric reductase; Validated; Region: PRK06370
487521006505	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521006506	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521006507	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487521006508	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
487521006509	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
487521006510	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521006511	S-adenosylmethionine binding site [chemical binding]; other site
487521006512	Protein of unknown function (DUF503); Region: DUF503; cl00669
487521006513	proteasome ATPase; Region: pup_AAA; TIGR03689
487521006514	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521006515	Walker A motif; other site
487521006516	ATP binding site [chemical binding]; other site
487521006517	Walker B motif; other site
487521006518	arginine finger; other site
487521006519	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
487521006520	Pup-like protein; Region: Pup; cl05289
487521006521	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
487521006522	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
487521006523	active site
487521006524	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
487521006525	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
487521006526	active site
487521006527	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
487521006528	Predicted transcriptional regulator [Transcription]; Region: COG2378
487521006529	WYL domain; Region: WYL; pfam13280
487521006530	Predicted transcriptional regulator [Transcription]; Region: COG2378
487521006531	WYL domain; Region: WYL; pfam13280
487521006532	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
487521006533	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
487521006534	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
487521006535	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
487521006536	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521006537	ATP binding site [chemical binding]; other site
487521006538	putative Mg++ binding site [ion binding]; other site
487521006539	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521006540	nucleotide binding region [chemical binding]; other site
487521006541	ATP-binding site [chemical binding]; other site
487521006542	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
487521006543	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
487521006544	5'-3' exonuclease; Region: 53EXOc; smart00475
487521006545	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
487521006546	active site
487521006547	metal binding site 1 [ion binding]; metal-binding site
487521006548	putative 5' ssDNA interaction site; other site
487521006549	metal binding site 3; metal-binding site
487521006550	metal binding site 2 [ion binding]; metal-binding site
487521006551	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
487521006552	putative DNA binding site [nucleotide binding]; other site
487521006553	putative metal binding site [ion binding]; other site
487521006554	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487521006555	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
487521006556	active site
487521006557	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521006558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006559	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487521006560	NAD(P) binding site [chemical binding]; other site
487521006561	active site
487521006562	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
487521006563	active site
487521006564	putative homodimer interface [polypeptide binding]; other site
487521006565	SAM binding site [chemical binding]; other site
487521006566	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
487521006567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521006568	S-adenosylmethionine binding site [chemical binding]; other site
487521006569	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
487521006570	active site
487521006571	SAM binding site [chemical binding]; other site
487521006572	homodimer interface [polypeptide binding]; other site
487521006573	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
487521006574	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
487521006575	Predicted integral membrane protein [Function unknown]; Region: COG5660
487521006576	Putative zinc-finger; Region: zf-HC2; pfam13490
487521006577	Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039
487521006578	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
487521006579	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521006580	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521006581	DNA binding residues [nucleotide binding]
487521006582	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521006583	PPE family; Region: PPE; pfam00823
487521006584	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
487521006585	active site
487521006586	SAM binding site [chemical binding]; other site
487521006587	homodimer interface [polypeptide binding]; other site
487521006588	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
487521006589	active site
487521006590	SAM binding site [chemical binding]; other site
487521006591	homodimer interface [polypeptide binding]; other site
487521006592	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
487521006593	Precorrin-8X methylmutase; Region: CbiC; pfam02570
487521006594	precorrin-3B synthase; Region: CobG; TIGR02435
487521006595	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
487521006596	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
487521006597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521006598	dimer interface [polypeptide binding]; other site
487521006599	conserved gate region; other site
487521006600	putative PBP binding loops; other site
487521006601	ABC-ATPase subunit interface; other site
487521006602	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
487521006603	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
487521006604	Walker A/P-loop; other site
487521006605	ATP binding site [chemical binding]; other site
487521006606	Q-loop/lid; other site
487521006607	ABC transporter signature motif; other site
487521006608	Walker B; other site
487521006609	D-loop; other site
487521006610	H-loop/switch region; other site
487521006611	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
487521006612	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521006613	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
487521006614	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
487521006615	Moco binding site; other site
487521006616	metal coordination site [ion binding]; other site
487521006617	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
487521006618	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
487521006619	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
487521006620	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
487521006621	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
487521006622	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
487521006623	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
487521006624	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
487521006625	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
487521006626	active site
487521006627	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
487521006628	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
487521006629	putative active site [active]
487521006630	catalytic triad [active]
487521006631	putative dimer interface [polypeptide binding]; other site
487521006632	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
487521006633	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
487521006634	Ligand binding site; other site
487521006635	Putative Catalytic site; other site
487521006636	DXD motif; other site
487521006637	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
487521006638	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
487521006639	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521006640	active site
487521006641	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521006642	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
487521006643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006644	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
487521006645	Enoylreductase; Region: PKS_ER; smart00829
487521006646	NAD(P) binding site [chemical binding]; other site
487521006647	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
487521006648	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
487521006649	putative NADP binding site [chemical binding]; other site
487521006650	active site
487521006651	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521006652	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
487521006653	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521006654	active site
487521006655	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521006656	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
487521006657	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006658	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
487521006659	Enoylreductase; Region: PKS_ER; smart00829
487521006660	NAD(P) binding site [chemical binding]; other site
487521006661	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
487521006662	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
487521006663	putative NADP binding site [chemical binding]; other site
487521006664	active site
487521006665	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521006666	hypothetical protein; Provisional; Region: PRK05865
487521006667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006668	NAD(P) binding site [chemical binding]; other site
487521006669	active site
487521006670	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
487521006671	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521006672	Cytochrome P450; Region: p450; cl12078
487521006673	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006674	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
487521006675	NAD(P) binding site [chemical binding]; other site
487521006676	active site
487521006677	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521006678	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521006679	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
487521006680	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
487521006681	Walker A motif; other site
487521006682	ATP binding site [chemical binding]; other site
487521006683	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
487521006684	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
487521006685	metal ion-dependent adhesion site (MIDAS); other site
487521006686	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521006687	short chain dehydrogenase; Provisional; Region: PRK07814
487521006688	classical (c) SDRs; Region: SDR_c; cd05233
487521006689	NAD(P) binding site [chemical binding]; other site
487521006690	active site
487521006691	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521006692	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521006693	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521006694	classical (c) SDRs; Region: SDR_c; cd05233
487521006695	NAD(P) binding site [chemical binding]; other site
487521006696	active site
487521006697	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521006698	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521006699	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521006700	Cytochrome P450; Region: p450; cl12078
487521006701	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
487521006702	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521006703	substrate binding pocket [chemical binding]; other site
487521006704	catalytic triad [active]
487521006705	Phosphotransferase enzyme family; Region: APH; pfam01636
487521006706	Ecdysteroid kinase; Region: EcKinase; cl17738
487521006707	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
487521006708	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
487521006709	ATP-binding site [chemical binding]; other site
487521006710	Gluconate-6-phosphate binding site [chemical binding]; other site
487521006711	Shikimate kinase; Region: SKI; pfam01202
487521006712	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521006713	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521006714	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521006715	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521006716	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
487521006717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
487521006718	AAA domain; Region: AAA_33; pfam13671
487521006719	Predicted membrane protein [Function unknown]; Region: COG2259
487521006720	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
487521006721	catalytic triad [active]
487521006722	conserved cis-peptide bond; other site
487521006723	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
487521006724	DoxX-like family; Region: DoxX_2; pfam13564
487521006725	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
487521006726	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521006727	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
487521006728	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487521006729	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487521006730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521006731	dimer interface [polypeptide binding]; other site
487521006732	conserved gate region; other site
487521006733	putative PBP binding loops; other site
487521006734	ABC-ATPase subunit interface; other site
487521006735	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487521006736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521006737	dimer interface [polypeptide binding]; other site
487521006738	conserved gate region; other site
487521006739	putative PBP binding loops; other site
487521006740	ABC-ATPase subunit interface; other site
487521006741	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
487521006742	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
487521006743	Walker A/P-loop; other site
487521006744	ATP binding site [chemical binding]; other site
487521006745	Q-loop/lid; other site
487521006746	ABC transporter signature motif; other site
487521006747	Walker B; other site
487521006748	D-loop; other site
487521006749	H-loop/switch region; other site
487521006750	TOBE domain; Region: TOBE_2; pfam08402
487521006751	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
487521006752	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
487521006753	nucleophile elbow; other site
487521006754	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
487521006755	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
487521006756	Iron permease FTR1 family; Region: FTR1; cl00475
487521006757	Imelysin; Region: Peptidase_M75; pfam09375
487521006758	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
487521006759	OsmC-like protein; Region: OsmC; pfam02566
487521006760	cyanate hydratase; Validated; Region: PRK02866
487521006761	Helix-turn-helix domain; Region: HTH_19; pfam12844
487521006762	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
487521006763	oligomer interface [polypeptide binding]; other site
487521006764	active site
487521006765	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521006766	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521006767	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
487521006768	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
487521006769	DNA binding residues [nucleotide binding]
487521006770	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
487521006771	Acyltransferase family; Region: Acyl_transf_3; pfam01757
487521006772	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521006773	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521006774	active site
487521006775	catalytic tetrad [active]
487521006776	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
487521006777	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
487521006778	putative NADP binding site [chemical binding]; other site
487521006779	putative substrate binding site [chemical binding]; other site
487521006780	active site
487521006781	NADH(P)-binding; Region: NAD_binding_10; pfam13460
487521006782	extended (e) SDRs; Region: SDR_e; cd08946
487521006783	NAD(P) binding site [chemical binding]; other site
487521006784	active site
487521006785	substrate binding site [chemical binding]; other site
487521006786	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521006787	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487521006788	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521006789	active site 2 [active]
487521006790	active site 1 [active]
487521006791	Uncharacterized conserved protein [Function unknown]; Region: COG5649
487521006792	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521006793	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521006794	active site
487521006795	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
487521006796	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521006797	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
487521006798	homotetramer interface [polypeptide binding]; other site
487521006799	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521006800	NAD binding site [chemical binding]; other site
487521006801	homodimer interface [polypeptide binding]; other site
487521006802	active site
487521006803	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
487521006804	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521006805	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521006806	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521006807	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521006808	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521006809	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521006810	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521006811	substrate binding site [chemical binding]; other site
487521006812	oxyanion hole (OAH) forming residues; other site
487521006813	trimer interface [polypeptide binding]; other site
487521006814	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
487521006815	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
487521006816	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
487521006817	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
487521006818	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
487521006819	active site
487521006820	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
487521006821	catalytic triad [active]
487521006822	dimer interface [polypeptide binding]; other site
487521006823	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
487521006824	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
487521006825	active site
487521006826	ATP binding site [chemical binding]; other site
487521006827	Phosphotransferase enzyme family; Region: APH; pfam01636
487521006828	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
487521006829	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
487521006830	potential catalytic triad [active]
487521006831	conserved cys residue [active]
487521006832	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521006833	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521006834	Cellulose binding domain; Region: CBM_2; pfam00553
487521006835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521006836	NADH(P)-binding; Region: NAD_binding_10; pfam13460
487521006837	NAD(P) binding site [chemical binding]; other site
487521006838	active site
487521006839	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
487521006840	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521006841	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
487521006842	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
487521006843	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
487521006844	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521006845	hydrophobic ligand binding site; other site
487521006846	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
487521006847	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
487521006848	tetracycline repressor protein TetR; Provisional; Region: PRK13756
487521006849	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521006850	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
487521006851	Cutinase; Region: Cutinase; pfam01083
487521006852	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
487521006853	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521006854	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
487521006855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521006856	active site
487521006857	phosphorylation site [posttranslational modification]
487521006858	intermolecular recognition site; other site
487521006859	dimerization interface [polypeptide binding]; other site
487521006860	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
487521006861	Cutinase; Region: Cutinase; pfam01083
487521006862	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521006863	PPE family; Region: PPE; pfam00823
487521006864	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521006865	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
487521006866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521006867	putative PBP binding loops; other site
487521006868	ABC-ATPase subunit interface; other site
487521006869	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
487521006870	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
487521006871	Walker A/P-loop; other site
487521006872	ATP binding site [chemical binding]; other site
487521006873	Q-loop/lid; other site
487521006874	ABC transporter signature motif; other site
487521006875	Walker B; other site
487521006876	D-loop; other site
487521006877	H-loop/switch region; other site
487521006878	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
487521006879	NMT1-like family; Region: NMT1_2; pfam13379
487521006880	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487521006881	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521006882	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
487521006883	putative dimerization interface [polypeptide binding]; other site
487521006884	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521006885	PPE family; Region: PPE; pfam00823
487521006886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
487521006887	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
487521006888	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
487521006889	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521006890	SnoaL-like domain; Region: SnoaL_3; pfam13474
487521006891	short chain dehydrogenase; Provisional; Region: PRK06500
487521006892	classical (c) SDRs; Region: SDR_c; cd05233
487521006893	NAD(P) binding site [chemical binding]; other site
487521006894	active site
487521006895	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
487521006896	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
487521006897	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
487521006898	putative oligomer interface [polypeptide binding]; other site
487521006899	putative active site [active]
487521006900	metal binding site [ion binding]; metal-binding site
487521006901	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
487521006902	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521006903	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521006904	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
487521006905	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
487521006906	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
487521006907	hypothetical protein; Provisional; Region: PRK06834
487521006908	hypothetical protein; Provisional; Region: PRK07236
487521006909	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521006910	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
487521006911	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521006912	ATP binding site [chemical binding]; other site
487521006913	putative Mg++ binding site [ion binding]; other site
487521006914	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521006915	nucleotide binding region [chemical binding]; other site
487521006916	ATP-binding site [chemical binding]; other site
487521006917	Helicase associated domain (HA2); Region: HA2; pfam04408
487521006918	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
487521006919	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
487521006920	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
487521006921	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
487521006922	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521006923	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521006924	substrate binding site [chemical binding]; other site
487521006925	oxyanion hole (OAH) forming residues; other site
487521006926	trimer interface [polypeptide binding]; other site
487521006927	Cutinase; Region: Cutinase; pfam01083
487521006928	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
487521006929	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521006930	catalytic Zn binding site [ion binding]; other site
487521006931	NAD(P) binding site [chemical binding]; other site
487521006932	structural Zn binding site [ion binding]; other site
487521006933	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521006934	hydrophobic ligand binding site; other site
487521006935	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
487521006936	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521006937	NAD binding site [chemical binding]; other site
487521006938	catalytic Zn binding site [ion binding]; other site
487521006939	structural Zn binding site [ion binding]; other site
487521006940	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
487521006941	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
487521006942	MOSC domain; Region: MOSC; pfam03473
487521006943	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521006944	PPE family; Region: PPE; pfam00823
487521006945	Short C-terminal domain; Region: SHOCT; pfam09851
487521006946	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
487521006947	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
487521006948	active site
487521006949	TDP-binding site; other site
487521006950	acceptor substrate-binding pocket; other site
487521006951	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521006952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521006953	S-adenosylmethionine binding site [chemical binding]; other site
487521006954	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
487521006955	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521006956	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521006957	iron-sulfur cluster [ion binding]; other site
487521006958	[2Fe-2S] cluster binding site [ion binding]; other site
487521006959	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
487521006960	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
487521006961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
487521006962	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
487521006963	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
487521006964	metal binding site 2 [ion binding]; metal-binding site
487521006965	putative DNA binding helix; other site
487521006966	metal binding site 1 [ion binding]; metal-binding site
487521006967	dimer interface [polypeptide binding]; other site
487521006968	structural Zn2+ binding site [ion binding]; other site
487521006969	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
487521006970	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
487521006971	dimer interface [polypeptide binding]; other site
487521006972	active site
487521006973	heme binding site [chemical binding]; other site
487521006974	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
487521006975	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
487521006976	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521006977	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521006978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521006979	S-adenosylmethionine binding site [chemical binding]; other site
487521006980	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
487521006981	Protein of unknown function, DUF608; Region: DUF608; pfam04685
487521006982	Methyltransferase domain; Region: Methyltransf_24; pfam13578
487521006983	Cutinase; Region: Cutinase; pfam01083
487521006984	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521006985	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521006986	PE family; Region: PE; pfam00934
487521006987	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
487521006988	active site
487521006989	catalytic residues [active]
487521006990	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521006991	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
487521006992	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521006993	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
487521006994	NAD(P) binding site [chemical binding]; other site
487521006995	catalytic residues [active]
487521006996	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
487521006997	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521006998	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521006999	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
487521007000	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521007001	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521007002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007003	NAD(P) binding site [chemical binding]; other site
487521007004	active site
487521007005	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521007006	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521007007	active site
487521007008	YacP-like NYN domain; Region: NYN_YacP; cl01491
487521007009	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
487521007010	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521007011	FMN binding site [chemical binding]; other site
487521007012	substrate binding site [chemical binding]; other site
487521007013	putative catalytic residue [active]
487521007014	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
487521007015	dimer interface [polypeptide binding]; other site
487521007016	catalytic triad [active]
487521007017	peroxidatic and resolving cysteines [active]
487521007018	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
487521007019	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
487521007020	conserved cys residue [active]
487521007021	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521007022	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521007023	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
487521007024	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
487521007025	conserved cys residue [active]
487521007026	Predicted transcriptional regulators [Transcription]; Region: COG1733
487521007027	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
487521007028	SCP-2 sterol transfer family; Region: SCP2; pfam02036
487521007029	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521007030	short chain dehydrogenase; Provisional; Region: PRK05867
487521007031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007032	NAD(P) binding site [chemical binding]; other site
487521007033	active site
487521007034	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521007035	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521007036	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
487521007037	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
487521007038	acyl-activating enzyme (AAE) consensus motif; other site
487521007039	active site
487521007040	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
487521007041	putative hydrophobic ligand binding site [chemical binding]; other site
487521007042	protein interface [polypeptide binding]; other site
487521007043	gate; other site
487521007044	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
487521007045	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
487521007046	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
487521007047	tetramer interface [polypeptide binding]; other site
487521007048	active site
487521007049	Mg2+/Mn2+ binding site [ion binding]; other site
487521007050	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
487521007051	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521007052	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521007053	dimerization interface [polypeptide binding]; other site
487521007054	putative DNA binding site [nucleotide binding]; other site
487521007055	putative Zn2+ binding site [ion binding]; other site
487521007056	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
487521007057	putative hydrophobic ligand binding site [chemical binding]; other site
487521007058	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
487521007059	putative hydrophobic ligand binding site [chemical binding]; other site
487521007060	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
487521007061	substrate binding site [chemical binding]; other site
487521007062	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
487521007063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521007064	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521007065	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007066	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
487521007067	Nitronate monooxygenase; Region: NMO; pfam03060
487521007068	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521007069	FMN binding site [chemical binding]; other site
487521007070	substrate binding site [chemical binding]; other site
487521007071	putative catalytic residue [active]
487521007072	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
487521007073	FMN binding site [chemical binding]; other site
487521007074	dimer interface [polypeptide binding]; other site
487521007075	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521007076	hydrophobic ligand binding site; other site
487521007077	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
487521007078	Predicted membrane protein [Function unknown]; Region: COG1950
487521007079	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521007080	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521007081	active site
487521007082	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521007083	putative sialic acid transporter; Region: 2A0112; TIGR00891
487521007084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521007085	putative substrate translocation pore; other site
487521007086	competence damage-inducible protein A; Provisional; Region: PRK00549
487521007087	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
487521007088	putative MPT binding site; other site
487521007089	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
487521007090	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
487521007091	putative ADP-ribose binding site [chemical binding]; other site
487521007092	Domain of unknown function DUF77; Region: DUF77; pfam01910
487521007093	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
487521007094	putative active site [active]
487521007095	dimerization interface [polypeptide binding]; other site
487521007096	putative tRNAtyr binding site [nucleotide binding]; other site
487521007097	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521007098	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521007099	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487521007100	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521007101	NAD(P) binding site [chemical binding]; other site
487521007102	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521007103	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521007104	Nitronate monooxygenase; Region: NMO; pfam03060
487521007105	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521007106	FMN binding site [chemical binding]; other site
487521007107	substrate binding site [chemical binding]; other site
487521007108	putative catalytic residue [active]
487521007109	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521007110	Cytochrome P450; Region: p450; cl12078
487521007111	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
487521007112	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
487521007113	putative NAD(P) binding site [chemical binding]; other site
487521007114	putative substrate binding site [chemical binding]; other site
487521007115	catalytic Zn binding site [ion binding]; other site
487521007116	structural Zn binding site [ion binding]; other site
487521007117	YceI-like domain; Region: YceI; smart00867
487521007118	Putative esterase; Region: Esterase; pfam00756
487521007119	Chorismate mutase type II; Region: CM_2; cl00693
487521007120	chorismate mutase; Provisional; Region: PRK09269
487521007121	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
487521007122	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521007123	hydrophobic ligand binding site; other site
487521007124	short chain dehydrogenase; Provisional; Region: PRK08267
487521007125	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007126	NAD(P) binding site [chemical binding]; other site
487521007127	active site
487521007128	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
487521007129	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521007130	Cytochrome P450; Region: p450; cl12078
487521007131	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521007132	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521007133	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
487521007134	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
487521007135	probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854
487521007136	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521007137	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521007138	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521007139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521007140	Major Facilitator Superfamily; Region: MFS_1; pfam07690
487521007141	putative substrate translocation pore; other site
487521007142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521007143	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
487521007144	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
487521007145	heme binding site [chemical binding]; other site
487521007146	ferroxidase pore; other site
487521007147	ferroxidase diiron center [ion binding]; other site
487521007148	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
487521007149	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521007150	substrate binding site [chemical binding]; other site
487521007151	oxyanion hole (OAH) forming residues; other site
487521007152	trimer interface [polypeptide binding]; other site
487521007153	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521007154	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
487521007155	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521007156	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
487521007157	dimerization interface [polypeptide binding]; other site
487521007158	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
487521007159	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
487521007160	dimer interface [polypeptide binding]; other site
487521007161	decamer (pentamer of dimers) interface [polypeptide binding]; other site
487521007162	catalytic triad [active]
487521007163	peroxidatic and resolving cysteines [active]
487521007164	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
487521007165	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521007166	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354
487521007167	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
487521007168	active site
487521007169	catalytic site [active]
487521007170	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
487521007171	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
487521007172	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
487521007173	active site
487521007174	substrate binding site [chemical binding]; other site
487521007175	FMN binding site [chemical binding]; other site
487521007176	putative catalytic residues [active]
487521007177	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
487521007178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521007179	Walker A motif; other site
487521007180	ATP binding site [chemical binding]; other site
487521007181	Walker B motif; other site
487521007182	arginine finger; other site
487521007183	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
487521007184	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521007185	TfoX N-terminal domain; Region: TfoX_N; cl17592
487521007186	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
487521007187	minor groove reading motif; other site
487521007188	helix-hairpin-helix signature motif; other site
487521007189	Protein of unknown function DUF72; Region: DUF72; pfam01904
487521007190	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
487521007191	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521007192	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521007193	hypothetical protein; Provisional; Region: PRK12320
487521007194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007195	NAD(P) binding site [chemical binding]; other site
487521007196	active site
487521007197	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
487521007198	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521007199	active site
487521007200	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521007201	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521007202	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521007203	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521007204	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
487521007205	short chain dehydrogenase; Provisional; Region: PRK07825
487521007206	classical (c) SDRs; Region: SDR_c; cd05233
487521007207	NAD(P) binding site [chemical binding]; other site
487521007208	active site
487521007209	putative phosphoketolase; Provisional; Region: PRK05261
487521007210	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
487521007211	TPP-binding site; other site
487521007212	XFP C-terminal domain; Region: XFP_C; pfam09363
487521007213	CAAX protease self-immunity; Region: Abi; pfam02517
487521007214	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487521007215	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
487521007216	NAD(P) binding site [chemical binding]; other site
487521007217	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
487521007218	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
487521007219	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521007220	Walker A/P-loop; other site
487521007221	ATP binding site [chemical binding]; other site
487521007222	Q-loop/lid; other site
487521007223	ABC transporter signature motif; other site
487521007224	Walker B; other site
487521007225	D-loop; other site
487521007226	H-loop/switch region; other site
487521007227	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
487521007228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521007229	putative PBP binding loops; other site
487521007230	ABC-ATPase subunit interface; other site
487521007231	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
487521007232	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
487521007233	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
487521007234	classical (c) SDRs; Region: SDR_c; cd05233
487521007235	NAD(P) binding site [chemical binding]; other site
487521007236	active site
487521007237	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
487521007238	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
487521007239	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521007240	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521007241	CoenzymeA binding site [chemical binding]; other site
487521007242	subunit interaction site [polypeptide binding]; other site
487521007243	PHB binding site; other site
487521007244	Predicted transcriptional regulator [Transcription]; Region: COG3682
487521007245	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
487521007246	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487521007247	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
487521007248	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
487521007249	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
487521007250	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487521007251	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
487521007252	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
487521007253	active site
487521007254	acyl carrier protein; Validated; Region: PRK05883
487521007255	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
487521007256	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521007257	acyl-activating enzyme (AAE) consensus motif; other site
487521007258	AMP binding site [chemical binding]; other site
487521007259	active site
487521007260	CoA binding site [chemical binding]; other site
487521007261	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521007262	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521007263	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521007264	active site
487521007265	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
487521007266	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
487521007267	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
487521007268	Domain of unknown function DUF21; Region: DUF21; pfam01595
487521007269	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
487521007270	Transporter associated domain; Region: CorC_HlyC; smart01091
487521007271	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
487521007272	Domain of unknown function DUF21; Region: DUF21; pfam01595
487521007273	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
487521007274	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
487521007275	active site
487521007276	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
487521007277	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
487521007278	metal ion-dependent adhesion site (MIDAS); other site
487521007279	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
487521007280	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
487521007281	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521007282	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007283	glycine dehydrogenase; Provisional; Region: PRK05367
487521007284	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
487521007285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521007286	tetramer interface [polypeptide binding]; other site
487521007287	catalytic residue [active]
487521007288	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
487521007289	tetramer interface [polypeptide binding]; other site
487521007290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521007291	catalytic residue [active]
487521007292	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
487521007293	DNA binding residues [nucleotide binding]
487521007294	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487521007295	putative dimer interface [polypeptide binding]; other site
487521007296	Bifunctional nuclease; Region: DNase-RNase; pfam02577
487521007297	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
487521007298	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487521007299	DNA binding residues [nucleotide binding]
487521007300	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521007301	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521007302	phosphopeptide binding site; other site
487521007303	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
487521007304	lipoyl attachment site [posttranslational modification]; other site
487521007305	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
487521007306	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
487521007307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
487521007308	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
487521007309	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
487521007310	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
487521007311	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
487521007312	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
487521007313	nucleotide binding region [chemical binding]; other site
487521007314	ATP-binding site [chemical binding]; other site
487521007315	hypothetical protein; Provisional; Region: PRK05858
487521007316	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487521007317	PYR/PP interface [polypeptide binding]; other site
487521007318	dimer interface [polypeptide binding]; other site
487521007319	TPP binding site [chemical binding]; other site
487521007320	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521007321	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
487521007322	TPP-binding site; other site
487521007323	dimer interface [polypeptide binding]; other site
487521007324	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
487521007325	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
487521007326	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
487521007327	hypothetical protein; Validated; Region: PRK07121
487521007328	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
487521007329	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487521007330	active site
487521007331	metal binding site [ion binding]; metal-binding site
487521007332	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521007333	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007334	Domain of unknown function (DUF385); Region: DUF385; cl04387
487521007335	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
487521007336	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
487521007337	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
487521007338	MgtC family; Region: MgtC; pfam02308
487521007339	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521007340	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007341	PPE family; Region: PPE; pfam00823
487521007342	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521007343	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007344	PPE family; Region: PPE; pfam00823
487521007345	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521007346	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521007347	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521007348	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007349	PPE family; Region: PPE; pfam00823
487521007350	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521007351	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007352	PPE family; Region: PPE; pfam00823
487521007353	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521007354	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007355	PPE family; Region: PPE; pfam00823
487521007356	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
487521007357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521007358	Walker A motif; other site
487521007359	ATP binding site [chemical binding]; other site
487521007360	Walker B motif; other site
487521007361	arginine finger; other site
487521007362	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
487521007363	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
487521007364	catalytic residues [active]
487521007365	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
487521007366	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
487521007367	active site
487521007368	catalytic residues [active]
487521007369	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
487521007370	EspG family; Region: ESX-1_EspG; pfam14011
487521007371	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
487521007372	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
487521007373	PE family; Region: PE; pfam00934
487521007374	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007375	PPE family; Region: PPE; pfam00823
487521007376	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007377	PPE family; Region: PPE; pfam00823
487521007378	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007379	PPE family; Region: PPE; pfam00823
487521007380	PE family; Region: PE; pfam00934
487521007381	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521007382	PPE family; Region: PPE; pfam00823
487521007383	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521007384	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
487521007385	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521007386	Cytochrome P450; Region: p450; cl12078
487521007387	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
487521007388	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521007389	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
487521007390	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521007391	Protein of unknown function (DUF690); Region: DUF690; pfam05108
487521007392	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
487521007393	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
487521007394	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521007395	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521007396	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521007397	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
487521007398	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
487521007399	Moco binding site; other site
487521007400	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
487521007401	metal coordination site [ion binding]; other site
487521007402	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
487521007403	hydrophobic ligand binding site; other site
487521007404	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
487521007405	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521007406	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521007407	Helix-turn-helix domain; Region: HTH_18; pfam12833
487521007408	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521007409	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521007410	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521007411	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521007412	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521007413	classical (c) SDRs; Region: SDR_c; cd05233
487521007414	NAD(P) binding site [chemical binding]; other site
487521007415	active site
487521007416	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
487521007417	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
487521007418	tetramer interface [polypeptide binding]; other site
487521007419	TPP-binding site [chemical binding]; other site
487521007420	heterodimer interface [polypeptide binding]; other site
487521007421	phosphorylation loop region [posttranslational modification]
487521007422	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
487521007423	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
487521007424	alpha subunit interface [polypeptide binding]; other site
487521007425	TPP binding site [chemical binding]; other site
487521007426	heterodimer interface [polypeptide binding]; other site
487521007427	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
487521007428	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
487521007429	E3 interaction surface; other site
487521007430	lipoyl attachment site [posttranslational modification]; other site
487521007431	enoyl-CoA hydratase; Provisional; Region: PRK06144
487521007432	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521007433	substrate binding site [chemical binding]; other site
487521007434	oxyanion hole (OAH) forming residues; other site
487521007435	trimer interface [polypeptide binding]; other site
487521007436	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
487521007437	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521007438	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521007439	acyl-activating enzyme (AAE) consensus motif; other site
487521007440	putative AMP binding site [chemical binding]; other site
487521007441	putative active site [active]
487521007442	acyl-activating enzyme (AAE) consensus motif; other site
487521007443	putative CoA binding site [chemical binding]; other site
487521007444	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521007445	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521007446	[2Fe-2S] cluster binding site [ion binding]; other site
487521007447	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
487521007448	putative alpha subunit interface [polypeptide binding]; other site
487521007449	putative active site [active]
487521007450	putative substrate binding site [chemical binding]; other site
487521007451	Fe binding site [ion binding]; other site
487521007452	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
487521007453	enoyl-CoA hydratase; Provisional; Region: PRK06190
487521007454	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521007455	substrate binding site [chemical binding]; other site
487521007456	oxyanion hole (OAH) forming residues; other site
487521007457	trimer interface [polypeptide binding]; other site
487521007458	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
487521007459	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
487521007460	thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887
487521007461	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
487521007462	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
487521007463	DEAD-like helicases superfamily; Region: DEXDc; smart00487
487521007464	ATP binding site [chemical binding]; other site
487521007465	Mg++ binding site [ion binding]; other site
487521007466	motif III; other site
487521007467	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521007468	nucleotide binding region [chemical binding]; other site
487521007469	ATP-binding site [chemical binding]; other site
487521007470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521007471	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521007472	S-adenosylmethionine binding site [chemical binding]; other site
487521007473	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521007474	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007475	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
487521007476	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521007477	active site
487521007478	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521007479	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521007480	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007481	classical (c) SDRs; Region: SDR_c; cd05233
487521007482	NAD(P) binding site [chemical binding]; other site
487521007483	active site
487521007484	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
487521007485	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521007486	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
487521007487	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521007488	DNA binding residues [nucleotide binding]
487521007489	Methyltransferase domain; Region: Methyltransf_24; pfam13578
487521007490	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
487521007491	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007492	Cytochrome P450; Region: p450; cl12078
487521007493	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521007494	short chain dehydrogenase; Provisional; Region: PRK05854
487521007495	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
487521007496	putative NAD(P) binding site [chemical binding]; other site
487521007497	active site
487521007498	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521007499	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487521007500	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
487521007501	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
487521007502	active site
487521007503	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487521007504	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
487521007505	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
487521007506	active site
487521007507	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521007508	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521007509	active site
487521007510	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007511	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
487521007512	NAD(P) binding site [chemical binding]; other site
487521007513	active site
487521007514	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521007515	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521007516	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521007517	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521007518	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521007519	enoyl-CoA hydratase; Provisional; Region: PRK12478
487521007520	substrate binding site [chemical binding]; other site
487521007521	oxyanion hole (OAH) forming residues; other site
487521007522	trimer interface [polypeptide binding]; other site
487521007523	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521007524	classical (c) SDRs; Region: SDR_c; cd05233
487521007525	NAD(P) binding site [chemical binding]; other site
487521007526	active site
487521007527	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521007528	Cytochrome P450; Region: p450; cl12078
487521007529	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521007530	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007531	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
487521007532	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
487521007533	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
487521007534	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
487521007535	hypothetical protein; Provisional; Region: PRK06185
487521007536	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521007537	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521007538	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
487521007539	Sulfatase; Region: Sulfatase; pfam00884
487521007540	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521007541	FMN binding site [chemical binding]; other site
487521007542	substrate binding site [chemical binding]; other site
487521007543	putative catalytic residue [active]
487521007544	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521007545	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
487521007546	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521007547	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
487521007548	intersubunit interface [polypeptide binding]; other site
487521007549	active site
487521007550	Zn2+ binding site [ion binding]; other site
487521007551	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521007552	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521007553	acyl-activating enzyme (AAE) consensus motif; other site
487521007554	AMP binding site [chemical binding]; other site
487521007555	active site
487521007556	CoA binding site [chemical binding]; other site
487521007557	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
487521007558	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
487521007559	Moco binding site; other site
487521007560	metal coordination site [ion binding]; other site
487521007561	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
487521007562	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
487521007563	putative di-iron ligands [ion binding]; other site
487521007564	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
487521007565	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
487521007566	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
487521007567	FAD binding pocket [chemical binding]; other site
487521007568	FAD binding motif [chemical binding]; other site
487521007569	phosphate binding motif [ion binding]; other site
487521007570	beta-alpha-beta structure motif; other site
487521007571	NAD binding pocket [chemical binding]; other site
487521007572	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521007573	catalytic loop [active]
487521007574	iron binding site [ion binding]; other site
487521007575	acyl-CoA synthetase; Provisional; Region: PRK13388
487521007576	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521007577	acyl-activating enzyme (AAE) consensus motif; other site
487521007578	AMP binding site [chemical binding]; other site
487521007579	active site
487521007580	CoA binding site [chemical binding]; other site
487521007581	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521007582	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521007583	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521007584	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521007585	thiolase; Provisional; Region: PRK06158
487521007586	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521007587	active site
487521007588	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
487521007589	putative active site [active]
487521007590	putative catalytic site [active]
487521007591	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
487521007592	active site
487521007593	catalytic site [active]
487521007594	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521007595	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521007596	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521007597	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521007598	active site
487521007599	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521007600	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521007601	phosphopeptide binding site; other site
487521007602	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521007603	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521007604	phosphopeptide binding site; other site
487521007605	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
487521007606	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487521007607	Walker A/P-loop; other site
487521007608	ATP binding site [chemical binding]; other site
487521007609	Q-loop/lid; other site
487521007610	ABC transporter signature motif; other site
487521007611	Walker B; other site
487521007612	D-loop; other site
487521007613	H-loop/switch region; other site
487521007614	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
487521007615	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
487521007616	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521007617	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521007618	short chain dehydrogenase; Provisional; Region: PRK06057
487521007619	classical (c) SDRs; Region: SDR_c; cd05233
487521007620	NAD(P) binding site [chemical binding]; other site
487521007621	active site
487521007622	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521007623	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
487521007624	molybdopterin cofactor binding site; other site
487521007625	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
487521007626	putative molybdopterin cofactor binding site; other site
487521007627	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521007628	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521007629	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521007630	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521007631	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
487521007632	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521007633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007634	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
487521007635	NAD(P) binding site [chemical binding]; other site
487521007636	active site
487521007637	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521007638	classical (c) SDRs; Region: SDR_c; cd05233
487521007639	NAD(P) binding site [chemical binding]; other site
487521007640	active site
487521007641	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521007642	classical (c) SDRs; Region: SDR_c; cd05233
487521007643	NAD(P) binding site [chemical binding]; other site
487521007644	active site
487521007645	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521007646	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521007647	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521007648	catalytic loop [active]
487521007649	iron binding site [ion binding]; other site
487521007650	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521007651	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521007652	active site
487521007653	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
487521007654	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
487521007655	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
487521007656	active site
487521007657	Fe binding site [ion binding]; other site
487521007658	hypothetical protein; Validated; Region: PRK07121
487521007659	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
487521007660	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521007661	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
487521007662	Bacterial transcriptional regulator; Region: IclR; pfam01614
487521007663	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521007664	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521007665	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
487521007666	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007667	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
487521007668	NAD(P) binding site [chemical binding]; other site
487521007669	active site
487521007670	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521007671	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521007672	acyl-CoA synthetase; Validated; Region: PRK08316
487521007673	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521007674	acyl-activating enzyme (AAE) consensus motif; other site
487521007675	putative AMP binding site [chemical binding]; other site
487521007676	putative active site [active]
487521007677	putative CoA binding site [chemical binding]; other site
487521007678	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521007679	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521007680	active site
487521007681	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521007682	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521007683	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521007684	SnoaL-like domain; Region: SnoaL_4; cl17707
487521007685	hypothetical protein; Provisional; Region: PRK06194
487521007686	classical (c) SDRs; Region: SDR_c; cd05233
487521007687	NAD(P) binding site [chemical binding]; other site
487521007688	active site
487521007689	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521007690	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521007691	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521007692	classical (c) SDRs; Region: SDR_c; cd05233
487521007693	NAD(P) binding site [chemical binding]; other site
487521007694	active site
487521007695	short chain dehydrogenase; Provisional; Region: PRK08303
487521007696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007697	NAD(P) binding site [chemical binding]; other site
487521007698	active site
487521007699	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521007700	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
487521007701	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845
487521007702	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
487521007703	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521007704	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521007705	active site
487521007706	Predicted transcriptional regulators [Transcription]; Region: COG1695
487521007707	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
487521007708	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521007709	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521007710	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
487521007711	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
487521007712	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
487521007713	hypothetical protein; Provisional; Region: PRK14059
487521007714	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
487521007715	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521007716	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521007717	active site
487521007718	ATP binding site [chemical binding]; other site
487521007719	substrate binding site [chemical binding]; other site
487521007720	activation loop (A-loop); other site
487521007721	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
487521007722	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521007723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521007724	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
487521007725	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487521007726	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521007727	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521007728	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
487521007729	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
487521007730	dimer interface [polypeptide binding]; other site
487521007731	active site
487521007732	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
487521007733	Ligand Binding Site [chemical binding]; other site
487521007734	Molecular Tunnel; other site
487521007735	Condensation domain; Region: Condensation; pfam00668
487521007736	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007737	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521007738	acyl-activating enzyme (AAE) consensus motif; other site
487521007739	AMP binding site [chemical binding]; other site
487521007740	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007741	Condensation domain; Region: Condensation; pfam00668
487521007742	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521007743	Condensation domain; Region: Condensation; pfam00668
487521007744	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521007745	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007746	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521007747	acyl-activating enzyme (AAE) consensus motif; other site
487521007748	AMP binding site [chemical binding]; other site
487521007749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521007750	S-adenosylmethionine binding site [chemical binding]; other site
487521007751	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521007752	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007753	Condensation domain; Region: Condensation; pfam00668
487521007754	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521007755	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521007756	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007757	acyl-activating enzyme (AAE) consensus motif; other site
487521007758	AMP binding site [chemical binding]; other site
487521007759	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007760	Condensation domain; Region: Condensation; pfam00668
487521007761	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521007762	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521007763	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007764	acyl-activating enzyme (AAE) consensus motif; other site
487521007765	AMP binding site [chemical binding]; other site
487521007766	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007767	peptide synthase; Provisional; Region: PRK12316
487521007768	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521007769	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007770	acyl-activating enzyme (AAE) consensus motif; other site
487521007771	AMP binding site [chemical binding]; other site
487521007772	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007773	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521007774	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521007775	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007776	acyl-activating enzyme (AAE) consensus motif; other site
487521007777	AMP binding site [chemical binding]; other site
487521007778	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007779	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521007780	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007781	acyl-activating enzyme (AAE) consensus motif; other site
487521007782	AMP binding site [chemical binding]; other site
487521007783	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007784	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521007785	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521007786	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521007787	acyl-activating enzyme (AAE) consensus motif; other site
487521007788	AMP binding site [chemical binding]; other site
487521007789	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521007790	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
487521007791	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
487521007792	nudix motif; other site
487521007793	MbtH-like protein; Region: MbtH; pfam03621
487521007794	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
487521007795	PAS fold; Region: PAS_4; pfam08448
487521007796	ANTAR domain; Region: ANTAR; pfam03861
487521007797	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
487521007798	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
487521007799	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
487521007800	DNA-binding site [nucleotide binding]; DNA binding site
487521007801	RNA-binding motif; other site
487521007802	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
487521007803	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
487521007804	putative di-iron ligands [ion binding]; other site
487521007805	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
487521007806	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
487521007807	NAD(P) binding site [chemical binding]; other site
487521007808	catalytic residues [active]
487521007809	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
487521007810	GTP-binding protein Der; Reviewed; Region: PRK03003
487521007811	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
487521007812	GTP/Mg2+ binding site [chemical binding]; other site
487521007813	Switch I region; other site
487521007814	G2 box; other site
487521007815	Switch II region; other site
487521007816	G3 box; other site
487521007817	G4 box; other site
487521007818	G5 box; other site
487521007819	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
487521007820	G1 box; other site
487521007821	GTP/Mg2+ binding site [chemical binding]; other site
487521007822	Switch I region; other site
487521007823	G2 box; other site
487521007824	G3 box; other site
487521007825	Switch II region; other site
487521007826	G4 box; other site
487521007827	G5 box; other site
487521007828	cytidylate kinase; Provisional; Region: cmk; PRK00023
487521007829	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
487521007830	CMP-binding site; other site
487521007831	The sites determining sugar specificity; other site
487521007832	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
487521007833	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487521007834	RNA binding surface [nucleotide binding]; other site
487521007835	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
487521007836	active site
487521007837	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
487521007838	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
487521007839	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
487521007840	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
487521007841	P loop; other site
487521007842	Nucleotide binding site [chemical binding]; other site
487521007843	DTAP/Switch II; other site
487521007844	Switch I; other site
487521007845	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
487521007846	Magnesium ion binding site [ion binding]; other site
487521007847	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
487521007848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521007849	S-adenosylmethionine binding site [chemical binding]; other site
487521007850	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
487521007851	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521007852	active site
487521007853	DNA binding site [nucleotide binding]
487521007854	Int/Topo IB signature motif; other site
487521007855	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
487521007856	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
487521007857	dimer interface [polypeptide binding]; other site
487521007858	active site
487521007859	ADP-ribose binding site [chemical binding]; other site
487521007860	nudix motif; other site
487521007861	metal binding site [ion binding]; metal-binding site
487521007862	CTP synthetase; Validated; Region: pyrG; PRK05380
487521007863	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
487521007864	Catalytic site [active]
487521007865	active site
487521007866	UTP binding site [chemical binding]; other site
487521007867	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
487521007868	active site
487521007869	putative oxyanion hole; other site
487521007870	catalytic triad [active]
487521007871	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
487521007872	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
487521007873	Thiamine pyrophosphokinase; Region: TPK; cl08415
487521007874	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
487521007875	DNA repair protein RecN; Region: recN; TIGR00634
487521007876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521007877	Walker A/P-loop; other site
487521007878	ATP binding site [chemical binding]; other site
487521007879	Q-loop/lid; other site
487521007880	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
487521007881	ABC transporter signature motif; other site
487521007882	Walker B; other site
487521007883	D-loop; other site
487521007884	H-loop/switch region; other site
487521007885	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
487521007886	ATP-NAD kinase; Region: NAD_kinase; pfam01513
487521007887	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
487521007888	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487521007889	RNA binding surface [nucleotide binding]; other site
487521007890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521007891	S-adenosylmethionine binding site [chemical binding]; other site
487521007892	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
487521007893	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
487521007894	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521007895	active site
487521007896	motif I; other site
487521007897	motif II; other site
487521007898	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
487521007899	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
487521007900	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521007901	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
487521007902	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
487521007903	active site
487521007904	HIGH motif; other site
487521007905	dimer interface [polypeptide binding]; other site
487521007906	KMSKS motif; other site
487521007907	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487521007908	RNA binding surface [nucleotide binding]; other site
487521007909	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
487521007910	active site
487521007911	DNA binding site [nucleotide binding]
487521007912	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
487521007913	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
487521007914	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487521007915	Walker A/P-loop; other site
487521007916	ATP binding site [chemical binding]; other site
487521007917	Q-loop/lid; other site
487521007918	ABC transporter signature motif; other site
487521007919	Walker B; other site
487521007920	D-loop; other site
487521007921	H-loop/switch region; other site
487521007922	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487521007923	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
487521007924	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521007925	Uncharacterized conserved protein [Function unknown]; Region: COG2835
487521007926	acyl-CoA synthetase; Validated; Region: PRK07868
487521007927	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
487521007928	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521007929	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521007930	active site
487521007931	CoA binding site [chemical binding]; other site
487521007932	AMP binding site [chemical binding]; other site
487521007933	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
487521007934	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
487521007935	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
487521007936	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
487521007937	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
487521007938	short chain dehydrogenase; Provisional; Region: PRK07109
487521007939	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
487521007940	putative NAD(P) binding site [chemical binding]; other site
487521007941	active site
487521007942	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
487521007943	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
487521007944	putative active site pocket [active]
487521007945	putative metal binding site [ion binding]; other site
487521007946	PAS fold; Region: PAS_3; pfam08447
487521007947	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
487521007948	putative active site [active]
487521007949	heme pocket [chemical binding]; other site
487521007950	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521007951	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
487521007952	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487521007953	ABC transporter; Region: ABC_tran_2; pfam12848
487521007954	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487521007955	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521007956	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521007957	active site
487521007958	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
487521007959	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
487521007960	malonyl-CoA binding site [chemical binding]; other site
487521007961	dimer interface [polypeptide binding]; other site
487521007962	active site
487521007963	product binding site; other site
487521007964	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
487521007965	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521007966	active site
487521007967	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
487521007968	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521007969	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521007970	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
487521007971	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521007972	active site
487521007973	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521007974	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
487521007975	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007976	Enoylreductase; Region: PKS_ER; smart00829
487521007977	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
487521007978	NAD(P) binding site [chemical binding]; other site
487521007979	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
487521007980	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
487521007981	putative NADP binding site [chemical binding]; other site
487521007982	active site
487521007983	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521007984	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
487521007985	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
487521007986	active site
487521007987	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
487521007988	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
487521007989	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521007990	Enoylreductase; Region: PKS_ER; smart00829
487521007991	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
487521007992	NAD(P) binding site [chemical binding]; other site
487521007993	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
487521007994	putative NADP binding site [chemical binding]; other site
487521007995	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
487521007996	active site
487521007997	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
487521007998	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
487521007999	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
487521008000	malonyl-CoA binding site [chemical binding]; other site
487521008001	dimer interface [polypeptide binding]; other site
487521008002	active site
487521008003	product binding site; other site
487521008004	argininosuccinate lyase; Provisional; Region: PRK00855
487521008005	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
487521008006	active sites [active]
487521008007	tetramer interface [polypeptide binding]; other site
487521008008	argininosuccinate synthase; Provisional; Region: PRK13820
487521008009	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
487521008010	ANP binding site [chemical binding]; other site
487521008011	Substrate Binding Site II [chemical binding]; other site
487521008012	Substrate Binding Site I [chemical binding]; other site
487521008013	arginine repressor; Provisional; Region: PRK03341
487521008014	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
487521008015	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
487521008016	ornithine carbamoyltransferase; Provisional; Region: PRK00779
487521008017	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
487521008018	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
487521008019	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
487521008020	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
487521008021	inhibitor-cofactor binding pocket; inhibition site
487521008022	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521008023	catalytic residue [active]
487521008024	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
487521008025	feedback inhibition sensing region; other site
487521008026	homohexameric interface [polypeptide binding]; other site
487521008027	nucleotide binding site [chemical binding]; other site
487521008028	N-acetyl-L-glutamate binding site [chemical binding]; other site
487521008029	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
487521008030	heterotetramer interface [polypeptide binding]; other site
487521008031	active site pocket [active]
487521008032	cleavage site
487521008033	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
487521008034	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
487521008035	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
487521008036	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
487521008037	putative tRNA-binding site [nucleotide binding]; other site
487521008038	B3/4 domain; Region: B3_4; pfam03483
487521008039	tRNA synthetase B5 domain; Region: B5; smart00874
487521008040	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
487521008041	dimer interface [polypeptide binding]; other site
487521008042	motif 1; other site
487521008043	motif 3; other site
487521008044	motif 2; other site
487521008045	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
487521008046	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
487521008047	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
487521008048	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
487521008049	dimer interface [polypeptide binding]; other site
487521008050	motif 1; other site
487521008051	active site
487521008052	motif 2; other site
487521008053	motif 3; other site
487521008054	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521008055	cyclase homology domain; Region: CHD; cd07302
487521008056	nucleotidyl binding site; other site
487521008057	metal binding site [ion binding]; metal-binding site
487521008058	dimer interface [polypeptide binding]; other site
487521008059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
487521008060	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
487521008061	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
487521008062	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
487521008063	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
487521008064	23S rRNA binding site [nucleotide binding]; other site
487521008065	L21 binding site [polypeptide binding]; other site
487521008066	L13 binding site [polypeptide binding]; other site
487521008067	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
487521008068	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
487521008069	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
487521008070	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
487521008071	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
487521008072	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
487521008073	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
487521008074	dimer interface [polypeptide binding]; other site
487521008075	putative anticodon binding site; other site
487521008076	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
487521008077	motif 1; other site
487521008078	dimer interface [polypeptide binding]; other site
487521008079	active site
487521008080	motif 2; other site
487521008081	motif 3; other site
487521008082	Predicted esterase [General function prediction only]; Region: COG0627
487521008083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521008084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521008085	hypothetical protein; Provisional; Region: PRK07877
487521008086	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
487521008087	ATP binding site [chemical binding]; other site
487521008088	substrate interface [chemical binding]; other site
487521008089	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
487521008090	dimer interface [polypeptide binding]; other site
487521008091	Methyltransferase domain; Region: Methyltransf_11; pfam08241
487521008092	Cytochrome P450; Region: p450; cl12078
487521008093	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521008094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
487521008095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
487521008096	metal binding site [ion binding]; metal-binding site
487521008097	active site
487521008098	I-site; other site
487521008099	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
487521008100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521008101	S-adenosylmethionine binding site [chemical binding]; other site
487521008102	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
487521008103	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
487521008104	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
487521008105	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
487521008106	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
487521008107	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521008108	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
487521008109	Ligand Binding Site [chemical binding]; other site
487521008110	Predicted membrane protein [Function unknown]; Region: COG5305
487521008111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521008112	Major Facilitator Superfamily; Region: MFS_1; pfam07690
487521008113	putative substrate translocation pore; other site
487521008114	excinuclease ABC subunit B; Provisional; Region: PRK05298
487521008115	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521008116	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521008117	nucleotide binding region [chemical binding]; other site
487521008118	ATP-binding site [chemical binding]; other site
487521008119	Ultra-violet resistance protein B; Region: UvrB; pfam12344
487521008120	UvrB/uvrC motif; Region: UVR; pfam02151
487521008121	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521008122	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
487521008123	active site
487521008124	ATP binding site [chemical binding]; other site
487521008125	substrate binding site [chemical binding]; other site
487521008126	activation loop (A-loop); other site
487521008127	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521008128	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521008129	phosphopeptide binding site; other site
487521008130	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521008131	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521008132	phosphopeptide binding site; other site
487521008133	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487521008134	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
487521008135	Walker A/P-loop; other site
487521008136	ATP binding site [chemical binding]; other site
487521008137	Q-loop/lid; other site
487521008138	ABC transporter signature motif; other site
487521008139	Walker B; other site
487521008140	D-loop; other site
487521008141	H-loop/switch region; other site
487521008142	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
487521008143	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
487521008144	Protein of unknown function (DUF402); Region: DUF402; cl00979
487521008145	CheB methylesterase; Region: CheB_methylest; pfam01339
487521008146	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
487521008147	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
487521008148	active site
487521008149	DNA binding site [nucleotide binding]
487521008150	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
487521008151	DNA binding site [nucleotide binding]
487521008152	LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861
487521008153	nucleotide binding site [chemical binding]; other site
487521008154	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
487521008155	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773
487521008156	DNA binding site [nucleotide binding]
487521008157	catalytic residue [active]
487521008158	H2TH interface [polypeptide binding]; other site
487521008159	putative catalytic residues [active]
487521008160	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
487521008161	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
487521008162	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
487521008163	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
487521008164	CoA-binding site [chemical binding]; other site
487521008165	ATP-binding [chemical binding]; other site
487521008166	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
487521008167	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
487521008168	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
487521008169	RNA binding site [nucleotide binding]; other site
487521008170	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
487521008171	RNA binding site [nucleotide binding]; other site
487521008172	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
487521008173	RNA binding site [nucleotide binding]; other site
487521008174	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
487521008175	RNA binding site [nucleotide binding]; other site
487521008176	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
487521008177	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
487521008178	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521008179	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521008180	5'-3' exonuclease; Region: 53EXOc; smart00475
487521008181	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
487521008182	active site
487521008183	metal binding site 1 [ion binding]; metal-binding site
487521008184	putative 5' ssDNA interaction site; other site
487521008185	metal binding site 3; metal-binding site
487521008186	metal binding site 2 [ion binding]; metal-binding site
487521008187	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
487521008188	putative DNA binding site [nucleotide binding]; other site
487521008189	putative metal binding site [ion binding]; other site
487521008190	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
487521008191	DNA polymerase I; Provisional; Region: PRK05755
487521008192	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
487521008193	active site
487521008194	DNA binding site [nucleotide binding]
487521008195	catalytic site [active]
487521008196	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
487521008197	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521008198	lipid-transfer protein; Provisional; Region: PRK06059
487521008199	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521008200	active site
487521008201	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
487521008202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521008203	active site
487521008204	phosphorylation site [posttranslational modification]
487521008205	intermolecular recognition site; other site
487521008206	dimerization interface [polypeptide binding]; other site
487521008207	ANTAR domain; Region: ANTAR; pfam03861
487521008208	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
487521008209	cyclase homology domain; Region: CHD; cd07302
487521008210	nucleotidyl binding site; other site
487521008211	metal binding site [ion binding]; metal-binding site
487521008212	dimer interface [polypeptide binding]; other site
487521008213	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
487521008214	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
487521008215	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
487521008216	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
487521008217	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521008218	Walker A/P-loop; other site
487521008219	ATP binding site [chemical binding]; other site
487521008220	ABC transporter; Region: ABC_tran; pfam00005
487521008221	Q-loop/lid; other site
487521008222	ABC transporter signature motif; other site
487521008223	Walker B; other site
487521008224	D-loop; other site
487521008225	H-loop/switch region; other site
487521008226	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
487521008227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521008228	Walker A/P-loop; other site
487521008229	ATP binding site [chemical binding]; other site
487521008230	Q-loop/lid; other site
487521008231	ABC transporter signature motif; other site
487521008232	Walker B; other site
487521008233	D-loop; other site
487521008234	H-loop/switch region; other site
487521008235	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
487521008236	acyl-CoA thioesterase II; Region: tesB; TIGR00189
487521008237	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
487521008238	active site
487521008239	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
487521008240	catalytic triad [active]
487521008241	dimer interface [polypeptide binding]; other site
487521008242	pyruvate kinase; Provisional; Region: PRK06247
487521008243	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
487521008244	active site
487521008245	domain interfaces; other site
487521008246	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
487521008247	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
487521008248	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
487521008249	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
487521008250	substrate binding site [chemical binding]; other site
487521008251	active site
487521008252	catalytic residues [active]
487521008253	heterodimer interface [polypeptide binding]; other site
487521008254	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
487521008255	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
487521008256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521008257	catalytic residue [active]
487521008258	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
487521008259	active site
487521008260	ribulose/triose binding site [chemical binding]; other site
487521008261	phosphate binding site [ion binding]; other site
487521008262	substrate (anthranilate) binding pocket [chemical binding]; other site
487521008263	product (indole) binding pocket [chemical binding]; other site
487521008264	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
487521008265	anthranilate synthase component I; Provisional; Region: PRK13571
487521008266	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
487521008267	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
487521008268	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
487521008269	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
487521008270	catalytic triad [active]
487521008271	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
487521008272	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
487521008273	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
487521008274	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
487521008275	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
487521008276	substrate binding site [chemical binding]; other site
487521008277	glutamase interaction surface [polypeptide binding]; other site
487521008278	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
487521008279	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
487521008280	active site
487521008281	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
487521008282	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
487521008283	catalytic residues [active]
487521008284	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
487521008285	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
487521008286	putative active site [active]
487521008287	oxyanion strand; other site
487521008288	catalytic triad [active]
487521008289	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
487521008290	4-fold oligomerization interface [polypeptide binding]; other site
487521008291	putative active site pocket [active]
487521008292	metal binding residues [ion binding]; metal-binding site
487521008293	3-fold/trimer interface [polypeptide binding]; other site
487521008294	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
487521008295	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521008296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521008297	homodimer interface [polypeptide binding]; other site
487521008298	catalytic residue [active]
487521008299	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
487521008300	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
487521008301	NAD binding site [chemical binding]; other site
487521008302	dimerization interface [polypeptide binding]; other site
487521008303	product binding site; other site
487521008304	substrate binding site [chemical binding]; other site
487521008305	zinc binding site [ion binding]; other site
487521008306	catalytic residues [active]
487521008307	Domain of unknown function (DUF385); Region: DUF385; cl04387
487521008308	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
487521008309	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
487521008310	dimerization interface [polypeptide binding]; other site
487521008311	active site
487521008312	L-aspartate oxidase; Provisional; Region: PRK07804
487521008313	L-aspartate oxidase; Provisional; Region: PRK06175
487521008314	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
487521008315	quinolinate synthetase; Provisional; Region: PRK09375
487521008316	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
487521008317	nudix motif; other site
487521008318	Secretory lipase; Region: LIP; pfam03583
487521008319	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
487521008320	biotin synthase; Validated; Region: PRK06256
487521008321	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521008322	FeS/SAM binding site; other site
487521008323	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
487521008324	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521008325	dimerization interface [polypeptide binding]; other site
487521008326	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
487521008327	cyclase homology domain; Region: CHD; cd07302
487521008328	nucleotidyl binding site; other site
487521008329	metal binding site [ion binding]; metal-binding site
487521008330	dimer interface [polypeptide binding]; other site
487521008331	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
487521008332	Mechanosensitive ion channel; Region: MS_channel; pfam00924
487521008333	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
487521008334	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
487521008335	ligand binding site [chemical binding]; other site
487521008336	flexible hinge region; other site
487521008337	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
487521008338	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
487521008339	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
487521008340	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
487521008341	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
487521008342	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521008343	catalytic residue [active]
487521008344	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
487521008345	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
487521008346	inhibitor-cofactor binding pocket; inhibition site
487521008347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521008348	catalytic residue [active]
487521008349	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
487521008350	NlpC/P60 family; Region: NLPC_P60; pfam00877
487521008351	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521008352	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
487521008353	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
487521008354	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
487521008355	active site
487521008356	catalytic site [active]
487521008357	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
487521008358	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
487521008359	active site
487521008360	catalytic site [active]
487521008361	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
487521008362	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
487521008363	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
487521008364	catalytic site [active]
487521008365	active site
487521008366	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
487521008367	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
487521008368	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521008369	DNA-binding site [nucleotide binding]; DNA binding site
487521008370	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521008371	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521008372	homodimer interface [polypeptide binding]; other site
487521008373	catalytic residue [active]
487521008374	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
487521008375	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
487521008376	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
487521008377	active site
487521008378	threonine dehydratase; Validated; Region: PRK08639
487521008379	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
487521008380	tetramer interface [polypeptide binding]; other site
487521008381	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521008382	catalytic residue [active]
487521008383	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
487521008384	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521008385	glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915
487521008386	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
487521008387	putative acyl-acceptor binding pocket; other site
487521008388	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
487521008389	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
487521008390	acyl-activating enzyme (AAE) consensus motif; other site
487521008391	putative AMP binding site [chemical binding]; other site
487521008392	putative active site [active]
487521008393	putative CoA binding site [chemical binding]; other site
487521008394	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521008395	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
487521008396	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
487521008397	DNA binding residues [nucleotide binding]
487521008398	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
487521008399	putative dimer interface [polypeptide binding]; other site
487521008400	putative metal binding residues [ion binding]; other site
487521008401	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
487521008402	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
487521008403	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
487521008404	active site
487521008405	PHP Thumb interface [polypeptide binding]; other site
487521008406	metal binding site [ion binding]; metal-binding site
487521008407	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
487521008408	generic binding surface II; other site
487521008409	generic binding surface I; other site
487521008410	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521008411	hydrophobic ligand binding site; other site
487521008412	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487521008413	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521008414	NAD(P) binding site [chemical binding]; other site
487521008415	active site
487521008416	classical (c) SDRs; Region: SDR_c; cd05233
487521008417	NAD(P) binding site [chemical binding]; other site
487521008418	active site
487521008419	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
487521008420	apolar tunnel; other site
487521008421	heme binding site [chemical binding]; other site
487521008422	dimerization interface [polypeptide binding]; other site
487521008423	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521008424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521008425	S-adenosylmethionine binding site [chemical binding]; other site
487521008426	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
487521008427	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
487521008428	active site
487521008429	lipoprotein signal peptidase; Provisional; Region: PRK14764
487521008430	lipoprotein signal peptidase; Provisional; Region: PRK14787
487521008431	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
487521008432	active site
487521008433	homodimer interface [polypeptide binding]; other site
487521008434	homotetramer interface [polypeptide binding]; other site
487521008435	DNA polymerase IV; Provisional; Region: PRK03348
487521008436	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
487521008437	active site
487521008438	DNA binding site [nucleotide binding]
487521008439	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
487521008440	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
487521008441	HIGH motif; other site
487521008442	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
487521008443	active site
487521008444	KMSKS motif; other site
487521008445	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
487521008446	tRNA binding surface [nucleotide binding]; other site
487521008447	anticodon binding site; other site
487521008448	Nitronate monooxygenase; Region: NMO; pfam03060
487521008449	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521008450	FMN binding site [chemical binding]; other site
487521008451	substrate binding site [chemical binding]; other site
487521008452	putative catalytic residue [active]
487521008453	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521008454	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521008455	Condensation domain; Region: Condensation; pfam00668
487521008456	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008457	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521008458	acyl-activating enzyme (AAE) consensus motif; other site
487521008459	AMP binding site [chemical binding]; other site
487521008460	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008461	Condensation domain; Region: Condensation; pfam00668
487521008462	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521008463	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008464	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008465	acyl-activating enzyme (AAE) consensus motif; other site
487521008466	AMP binding site [chemical binding]; other site
487521008467	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008468	peptide synthase; Provisional; Region: PRK12467
487521008469	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008470	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008471	acyl-activating enzyme (AAE) consensus motif; other site
487521008472	AMP binding site [chemical binding]; other site
487521008473	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008474	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008475	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008476	acyl-activating enzyme (AAE) consensus motif; other site
487521008477	AMP binding site [chemical binding]; other site
487521008478	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008479	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521008480	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008481	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008482	acyl-activating enzyme (AAE) consensus motif; other site
487521008483	AMP binding site [chemical binding]; other site
487521008484	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008485	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521008486	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008487	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008488	acyl-activating enzyme (AAE) consensus motif; other site
487521008489	AMP binding site [chemical binding]; other site
487521008490	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008491	Condensation domain; Region: Condensation; pfam00668
487521008492	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521008493	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008494	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008495	acyl-activating enzyme (AAE) consensus motif; other site
487521008496	AMP binding site [chemical binding]; other site
487521008497	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008498	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
487521008499	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
487521008500	putative NAD(P) binding site [chemical binding]; other site
487521008501	active site
487521008502	putative substrate binding site [chemical binding]; other site
487521008503	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008504	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521008505	acyl-activating enzyme (AAE) consensus motif; other site
487521008506	AMP binding site [chemical binding]; other site
487521008507	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008508	Condensation domain; Region: Condensation; pfam00668
487521008509	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521008510	Condensation domain; Region: Condensation; pfam00668
487521008511	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521008512	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008513	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008514	acyl-activating enzyme (AAE) consensus motif; other site
487521008515	AMP binding site [chemical binding]; other site
487521008516	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008517	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
487521008518	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
487521008519	putative NAD(P) binding site [chemical binding]; other site
487521008520	active site
487521008521	putative substrate binding site [chemical binding]; other site
487521008522	Condensation domain; Region: Condensation; pfam00668
487521008523	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008524	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521008525	acyl-activating enzyme (AAE) consensus motif; other site
487521008526	AMP binding site [chemical binding]; other site
487521008527	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008528	Condensation domain; Region: Condensation; pfam00668
487521008529	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521008530	Condensation domain; Region: Condensation; pfam00668
487521008531	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521008532	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008533	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008534	acyl-activating enzyme (AAE) consensus motif; other site
487521008535	AMP binding site [chemical binding]; other site
487521008536	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008537	Condensation domain; Region: Condensation; pfam00668
487521008538	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521008539	Condensation domain; Region: Condensation; pfam00668
487521008540	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521008541	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008542	MbtH-like protein; Region: MbtH; pfam03621
487521008543	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521008544	Transport protein; Region: actII; TIGR00833
487521008545	Transport protein; Region: actII; TIGR00833
487521008546	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
487521008547	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521008548	Walker A/P-loop; other site
487521008549	ATP binding site [chemical binding]; other site
487521008550	Q-loop/lid; other site
487521008551	ABC transporter signature motif; other site
487521008552	Walker B; other site
487521008553	D-loop; other site
487521008554	H-loop/switch region; other site
487521008555	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
487521008556	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487521008557	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
487521008558	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487521008559	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
487521008560	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
487521008561	metal-binding site
487521008562	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
487521008563	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
487521008564	NADP binding site [chemical binding]; other site
487521008565	active site
487521008566	putative substrate binding site [chemical binding]; other site
487521008567	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
487521008568	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
487521008569	NADP-binding site; other site
487521008570	homotetramer interface [polypeptide binding]; other site
487521008571	substrate binding site [chemical binding]; other site
487521008572	homodimer interface [polypeptide binding]; other site
487521008573	active site
487521008574	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
487521008575	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
487521008576	substrate binding site; other site
487521008577	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
487521008578	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
487521008579	NAD binding site [chemical binding]; other site
487521008580	homotetramer interface [polypeptide binding]; other site
487521008581	homodimer interface [polypeptide binding]; other site
487521008582	substrate binding site [chemical binding]; other site
487521008583	active site
487521008584	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
487521008585	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
487521008586	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521008587	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
487521008588	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
487521008589	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
487521008590	inhibitor-cofactor binding pocket; inhibition site
487521008591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521008592	catalytic residue [active]
487521008593	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
487521008594	Cephalosporin hydroxylase; Region: CmcI; pfam04989
487521008595	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487521008596	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
487521008597	active site
487521008598	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
487521008599	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
487521008600	NADP-binding site; other site
487521008601	homotetramer interface [polypeptide binding]; other site
487521008602	substrate binding site [chemical binding]; other site
487521008603	homodimer interface [polypeptide binding]; other site
487521008604	active site
487521008605	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521008606	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
487521008607	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
487521008608	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
487521008609	homodimer interface [polypeptide binding]; other site
487521008610	active site
487521008611	TDP-binding site; other site
487521008612	acceptor substrate-binding pocket; other site
487521008613	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487521008614	classical (c) SDRs; Region: SDR_c; cd05233
487521008615	NAD(P) binding site [chemical binding]; other site
487521008616	active site
487521008617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521008618	Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711
487521008619	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
487521008620	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
487521008621	homodimer interface [polypeptide binding]; other site
487521008622	active site
487521008623	TDP-binding site; other site
487521008624	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
487521008625	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
487521008626	homodimer interface [polypeptide binding]; other site
487521008627	active site
487521008628	TDP-binding site; other site
487521008629	acceptor substrate-binding pocket; other site
487521008630	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521008631	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521008632	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521008633	NAD(P) binding site [chemical binding]; other site
487521008634	active site
487521008635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
487521008636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
487521008637	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521008638	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521008639	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521008640	membrane ATPase/protein kinase; Provisional; Region: PRK09435
487521008641	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
487521008642	Walker A; other site
487521008643	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
487521008644	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
487521008645	active site
487521008646	substrate binding site [chemical binding]; other site
487521008647	coenzyme B12 binding site [chemical binding]; other site
487521008648	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
487521008649	B12 binding site [chemical binding]; other site
487521008650	cobalt ligand [ion binding]; other site
487521008651	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
487521008652	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
487521008653	heterodimer interface [polypeptide binding]; other site
487521008654	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
487521008655	Uncharacterized conserved protein [Function unknown]; Region: COG0398
487521008656	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
487521008657	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
487521008658	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
487521008659	Fatty acid desaturase; Region: FA_desaturase; pfam00487
487521008660	putative di-iron ligands [ion binding]; other site
487521008661	Condensation domain; Region: Condensation; pfam00668
487521008662	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008663	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521008664	acyl-activating enzyme (AAE) consensus motif; other site
487521008665	AMP binding site [chemical binding]; other site
487521008666	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008667	Condensation domain; Region: Condensation; pfam00668
487521008668	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521008669	Condensation domain; Region: Condensation; pfam00668
487521008670	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008671	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
487521008672	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
487521008673	acyl-activating enzyme (AAE) consensus motif; other site
487521008674	AMP binding site [chemical binding]; other site
487521008675	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521008676	Condensation domain; Region: Condensation; pfam00668
487521008677	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
487521008678	Condensation domain; Region: Condensation; pfam00668
487521008679	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
487521008680	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
487521008681	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521008682	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
487521008683	dimerization interface [polypeptide binding]; other site
487521008684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521008685	dimer interface [polypeptide binding]; other site
487521008686	phosphorylation site [posttranslational modification]
487521008687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521008688	Mg2+ binding site [ion binding]; other site
487521008689	G-X-G motif; other site
487521008690	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521008691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521008692	active site
487521008693	phosphorylation site [posttranslational modification]
487521008694	intermolecular recognition site; other site
487521008695	dimerization interface [polypeptide binding]; other site
487521008696	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521008697	DNA binding site [nucleotide binding]
487521008698	Domain of unknown function (DUF385); Region: DUF385; cl04387
487521008699	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
487521008700	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
487521008701	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
487521008702	ferrochelatase; Reviewed; Region: hemH; PRK00035
487521008703	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
487521008704	C-terminal domain interface [polypeptide binding]; other site
487521008705	active site
487521008706	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
487521008707	active site
487521008708	N-terminal domain interface [polypeptide binding]; other site
487521008709	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
487521008710	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
487521008711	NAD binding site [chemical binding]; other site
487521008712	homotetramer interface [polypeptide binding]; other site
487521008713	homodimer interface [polypeptide binding]; other site
487521008714	substrate binding site [chemical binding]; other site
487521008715	active site
487521008716	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
487521008717	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
487521008718	NAD(P) binding site [chemical binding]; other site
487521008719	homotetramer interface [polypeptide binding]; other site
487521008720	homodimer interface [polypeptide binding]; other site
487521008721	active site
487521008722	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
487521008723	putative active site [active]
487521008724	hypothetical protein; Provisional; Region: PRK13685
487521008725	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
487521008726	metal ion-dependent adhesion site (MIDAS); other site
487521008727	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
487521008728	Protein of unknown function DUF58; Region: DUF58; pfam01882
487521008729	MoxR-like ATPases [General function prediction only]; Region: COG0714
487521008730	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521008731	Walker A motif; other site
487521008732	ATP binding site [chemical binding]; other site
487521008733	Walker B motif; other site
487521008734	arginine finger; other site
487521008735	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
487521008736	NlpC/P60 family; Region: NLPC_P60; pfam00877
487521008737	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
487521008738	NlpC/P60 family; Region: NLPC_P60; pfam00877
487521008739	aconitate hydratase; Validated; Region: PRK09277
487521008740	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
487521008741	substrate binding site [chemical binding]; other site
487521008742	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
487521008743	ligand binding site [chemical binding]; other site
487521008744	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
487521008745	substrate binding site [chemical binding]; other site
487521008746	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521008747	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521008748	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
487521008749	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521008750	Walker A/P-loop; other site
487521008751	ATP binding site [chemical binding]; other site
487521008752	Q-loop/lid; other site
487521008753	ABC transporter signature motif; other site
487521008754	Walker B; other site
487521008755	D-loop; other site
487521008756	H-loop/switch region; other site
487521008757	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487521008758	enoyl-CoA hydratase; Provisional; Region: PRK05864
487521008759	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521008760	substrate binding site [chemical binding]; other site
487521008761	oxyanion hole (OAH) forming residues; other site
487521008762	trimer interface [polypeptide binding]; other site
487521008763	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
487521008764	catalytic residues [active]
487521008765	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
487521008766	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
487521008767	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521008768	active site
487521008769	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
487521008770	Transport protein; Region: actII; TIGR00833
487521008771	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521008772	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
487521008773	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
487521008774	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
487521008775	trimerization site [polypeptide binding]; other site
487521008776	active site
487521008777	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
487521008778	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
487521008779	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521008780	catalytic residue [active]
487521008781	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
487521008782	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
487521008783	Walker A/P-loop; other site
487521008784	ATP binding site [chemical binding]; other site
487521008785	Q-loop/lid; other site
487521008786	ABC transporter signature motif; other site
487521008787	Walker B; other site
487521008788	D-loop; other site
487521008789	H-loop/switch region; other site
487521008790	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
487521008791	FeS assembly protein SufD; Region: sufD; TIGR01981
487521008792	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
487521008793	FeS assembly protein SufB; Region: sufB; TIGR01980
487521008794	Predicted transcriptional regulator [Transcription]; Region: COG2345
487521008795	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521008796	putative DNA binding site [nucleotide binding]; other site
487521008797	putative Zn2+ binding site [ion binding]; other site
487521008798	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
487521008799	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
487521008800	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487521008801	Walker A/P-loop; other site
487521008802	ATP binding site [chemical binding]; other site
487521008803	Q-loop/lid; other site
487521008804	ABC transporter signature motif; other site
487521008805	Walker B; other site
487521008806	D-loop; other site
487521008807	H-loop/switch region; other site
487521008808	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487521008809	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
487521008810	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
487521008811	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
487521008812	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
487521008813	NADP binding site [chemical binding]; other site
487521008814	dimer interface [polypeptide binding]; other site
487521008815	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
487521008816	UbiA prenyltransferase family; Region: UbiA; pfam01040
487521008817	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
487521008818	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
487521008819	TPP-binding site [chemical binding]; other site
487521008820	dimer interface [polypeptide binding]; other site
487521008821	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
487521008822	PYR/PP interface [polypeptide binding]; other site
487521008823	dimer interface [polypeptide binding]; other site
487521008824	TPP binding site [chemical binding]; other site
487521008825	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
487521008826	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
487521008827	putative active site [active]
487521008828	transaldolase; Provisional; Region: PRK03903
487521008829	catalytic residue [active]
487521008830	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
487521008831	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
487521008832	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
487521008833	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
487521008834	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
487521008835	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
487521008836	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
487521008837	putative active site [active]
487521008838	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
487521008839	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
487521008840	putative active site [active]
487521008841	Zn binding site [ion binding]; other site
487521008842	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521008843	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521008844	active site
487521008845	catalytic tetrad [active]
487521008846	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
487521008847	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
487521008848	Preprotein translocase SecG subunit; Region: SecG; cl09123
487521008849	triosephosphate isomerase; Provisional; Region: PRK14567
487521008850	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
487521008851	substrate binding site [chemical binding]; other site
487521008852	dimer interface [polypeptide binding]; other site
487521008853	catalytic triad [active]
487521008854	Phosphoglycerate kinase; Region: PGK; pfam00162
487521008855	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
487521008856	substrate binding site [chemical binding]; other site
487521008857	hinge regions; other site
487521008858	ADP binding site [chemical binding]; other site
487521008859	catalytic site [active]
487521008860	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
487521008861	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
487521008862	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
487521008863	tetracycline repressor protein TetR; Provisional; Region: PRK13756
487521008864	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521008865	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
487521008866	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521008867	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521008868	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
487521008869	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521008870	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
487521008871	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521008872	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
487521008873	putative acyl-acceptor binding pocket; other site
487521008874	acyl-CoA synthetase; Provisional; Region: PRK13382
487521008875	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521008876	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521008877	acyl-activating enzyme (AAE) consensus motif; other site
487521008878	putative AMP binding site [chemical binding]; other site
487521008879	putative active site [active]
487521008880	putative CoA binding site [chemical binding]; other site
487521008881	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521008882	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521008883	substrate binding pocket [chemical binding]; other site
487521008884	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521008885	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521008886	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521008887	active site
487521008888	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521008889	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521008890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
487521008891	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
487521008892	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
487521008893	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
487521008894	phosphate binding site [ion binding]; other site
487521008895	putative substrate binding pocket [chemical binding]; other site
487521008896	dimer interface [polypeptide binding]; other site
487521008897	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
487521008898	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
487521008899	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
487521008900	GIY-YIG motif/motif A; other site
487521008901	active site
487521008902	catalytic site [active]
487521008903	putative DNA binding site [nucleotide binding]; other site
487521008904	metal binding site [ion binding]; metal-binding site
487521008905	UvrB/uvrC motif; Region: UVR; pfam02151
487521008906	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
487521008907	Helix-hairpin-helix motif; Region: HHH; pfam00633
487521008908	Cupin superfamily protein; Region: Cupin_4; pfam08007
487521008909	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521008910	PPE family; Region: PPE; pfam00823
487521008911	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
487521008912	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
487521008913	homopentamer interface [polypeptide binding]; other site
487521008914	active site
487521008915	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
487521008916	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
487521008917	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
487521008918	dimerization interface [polypeptide binding]; other site
487521008919	active site
487521008920	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
487521008921	Lumazine binding domain; Region: Lum_binding; pfam00677
487521008922	Lumazine binding domain; Region: Lum_binding; pfam00677
487521008923	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
487521008924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521008925	putative substrate translocation pore; other site
487521008926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521008927	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
487521008928	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
487521008929	catalytic motif [active]
487521008930	Zn binding site [ion binding]; other site
487521008931	RibD C-terminal domain; Region: RibD_C; pfam01872
487521008932	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
487521008933	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
487521008934	substrate binding site [chemical binding]; other site
487521008935	hexamer interface [polypeptide binding]; other site
487521008936	metal binding site [ion binding]; metal-binding site
487521008937	16S rRNA methyltransferase B; Provisional; Region: PRK14902
487521008938	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
487521008939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521008940	S-adenosylmethionine binding site [chemical binding]; other site
487521008941	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
487521008942	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
487521008943	putative active site [active]
487521008944	substrate binding site [chemical binding]; other site
487521008945	putative cosubstrate binding site; other site
487521008946	catalytic site [active]
487521008947	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
487521008948	substrate binding site [chemical binding]; other site
487521008949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521008950	S-adenosylmethionine binding site [chemical binding]; other site
487521008951	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521008952	MarR family; Region: MarR; pfam01047
487521008953	primosome assembly protein PriA; Provisional; Region: PRK14873
487521008954	Predicted membrane protein [Function unknown]; Region: COG3714
487521008955	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521008956	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521008957	substrate binding pocket [chemical binding]; other site
487521008958	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521008959	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521008960	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
487521008961	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
487521008962	S-adenosylmethionine synthetase; Validated; Region: PRK05250
487521008963	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
487521008964	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
487521008965	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
487521008966	Flavoprotein; Region: Flavoprotein; pfam02441
487521008967	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
487521008968	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
487521008969	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
487521008970	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
487521008971	catalytic site [active]
487521008972	G-X2-G-X-G-K; other site
487521008973	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
487521008974	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487521008975	DNA binding residues [nucleotide binding]
487521008976	TOBE domain; Region: TOBE; cl01440
487521008977	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
487521008978	active site
487521008979	dimer interface [polypeptide binding]; other site
487521008980	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
487521008981	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487521008982	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521008983	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
487521008984	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487521008985	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521008986	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
487521008987	IMP binding site; other site
487521008988	dimer interface [polypeptide binding]; other site
487521008989	interdomain contacts; other site
487521008990	partial ornithine binding site; other site
487521008991	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
487521008992	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
487521008993	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
487521008994	catalytic site [active]
487521008995	subunit interface [polypeptide binding]; other site
487521008996	dihydroorotase; Validated; Region: pyrC; PRK09357
487521008997	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521008998	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
487521008999	active site
487521009000	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
487521009001	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
487521009002	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
487521009003	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
487521009004	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521009005	active site
487521009006	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521009007	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521009008	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487521009009	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
487521009010	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
487521009011	L-aspartate oxidase; Provisional; Region: PRK06175
487521009012	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
487521009013	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
487521009014	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
487521009015	Walker A/P-loop; other site
487521009016	ATP binding site [chemical binding]; other site
487521009017	Q-loop/lid; other site
487521009018	ABC transporter signature motif; other site
487521009019	Walker B; other site
487521009020	D-loop; other site
487521009021	H-loop/switch region; other site
487521009022	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
487521009023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521009024	dimer interface [polypeptide binding]; other site
487521009025	conserved gate region; other site
487521009026	putative PBP binding loops; other site
487521009027	ABC-ATPase subunit interface; other site
487521009028	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
487521009029	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
487521009030	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
487521009031	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
487521009032	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521009033	DNA-binding site [nucleotide binding]; DNA binding site
487521009034	UTRA domain; Region: UTRA; pfam07702
487521009035	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
487521009036	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521009037	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521009038	catalytic residue [active]
487521009039	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
487521009040	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
487521009041	putative RNA binding site [nucleotide binding]; other site
487521009042	elongation factor P; Validated; Region: PRK00529
487521009043	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
487521009044	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
487521009045	RNA binding site [nucleotide binding]; other site
487521009046	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
487521009047	RNA binding site [nucleotide binding]; other site
487521009048	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
487521009049	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487521009050	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
487521009051	active site
487521009052	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
487521009053	Dehydroquinase class II; Region: DHquinase_II; pfam01220
487521009054	trimer interface [polypeptide binding]; other site
487521009055	active site
487521009056	dimer interface [polypeptide binding]; other site
487521009057	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
487521009058	active site
487521009059	dimer interface [polypeptide binding]; other site
487521009060	metal binding site [ion binding]; metal-binding site
487521009061	shikimate kinase; Reviewed; Region: aroK; PRK00131
487521009062	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
487521009063	ADP binding site [chemical binding]; other site
487521009064	magnesium binding site [ion binding]; other site
487521009065	putative shikimate binding site; other site
487521009066	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
487521009067	chorismate synthase; Validated; Region: PRK05382
487521009068	Tetramer interface [polypeptide binding]; other site
487521009069	active site
487521009070	FMN-binding site [chemical binding]; other site
487521009071	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
487521009072	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
487521009073	active site
487521009074	dimer interface [polypeptide binding]; other site
487521009075	non-prolyl cis peptide bond; other site
487521009076	insertion regions; other site
487521009077	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
487521009078	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
487521009079	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
487521009080	shikimate binding site; other site
487521009081	NAD(P) binding site [chemical binding]; other site
487521009082	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
487521009083	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
487521009084	dimerization interface [polypeptide binding]; other site
487521009085	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
487521009086	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
487521009087	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
487521009088	motif 1; other site
487521009089	active site
487521009090	motif 2; other site
487521009091	motif 3; other site
487521009092	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
487521009093	DHHA1 domain; Region: DHHA1; pfam02272
487521009094	Uncharacterized conserved protein [Function unknown]; Region: COG0432
487521009095	recombination factor protein RarA; Reviewed; Region: PRK13342
487521009096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521009097	Walker A motif; other site
487521009098	ATP binding site [chemical binding]; other site
487521009099	Walker B motif; other site
487521009100	arginine finger; other site
487521009101	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
487521009102	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
487521009103	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
487521009104	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
487521009105	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
487521009106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
487521009107	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
487521009108	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
487521009109	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
487521009110	Transglutaminase/protease-like homologues; Region: TGc; smart00460
487521009111	Protein of unknown function (DUF419); Region: DUF419; cl15265
487521009112	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
487521009113	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521009114	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
487521009115	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
487521009116	dimer interface [polypeptide binding]; other site
487521009117	anticodon binding site; other site
487521009118	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
487521009119	homodimer interface [polypeptide binding]; other site
487521009120	motif 1; other site
487521009121	active site
487521009122	motif 2; other site
487521009123	GAD domain; Region: GAD; pfam02938
487521009124	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
487521009125	active site
487521009126	motif 3; other site
487521009127	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
487521009128	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
487521009129	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
487521009130	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
487521009131	putative hydrophobic ligand binding site [chemical binding]; other site
487521009132	protein interface [polypeptide binding]; other site
487521009133	gate; other site
487521009134	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
487521009135	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487521009136	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
487521009137	inhibitor site; inhibition site
487521009138	active site
487521009139	dimer interface [polypeptide binding]; other site
487521009140	catalytic residue [active]
487521009141	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
487521009142	intersubunit interface [polypeptide binding]; other site
487521009143	active site
487521009144	Zn2+ binding site [ion binding]; other site
487521009145	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521009146	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487521009147	non-specific DNA binding site [nucleotide binding]; other site
487521009148	salt bridge; other site
487521009149	sequence-specific DNA binding site [nucleotide binding]; other site
487521009150	Cupin domain; Region: Cupin_2; pfam07883
487521009151	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
487521009152	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
487521009153	active site
487521009154	metal binding site [ion binding]; metal-binding site
487521009155	Radical SAM superfamily; Region: Radical_SAM; pfam04055
487521009156	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
487521009157	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521009158	hydrophobic ligand binding site; other site
487521009159	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521009160	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521009161	active site
487521009162	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
487521009163	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
487521009164	dimer interface [polypeptide binding]; other site
487521009165	motif 1; other site
487521009166	active site
487521009167	motif 2; other site
487521009168	motif 3; other site
487521009169	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
487521009170	anticodon binding site; other site
487521009171	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
487521009172	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
487521009173	active site
487521009174	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
487521009175	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487521009176	Zn2+ binding site [ion binding]; other site
487521009177	Mg2+ binding site [ion binding]; other site
487521009178	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
487521009179	synthetase active site [active]
487521009180	NTP binding site [chemical binding]; other site
487521009181	metal binding site [ion binding]; metal-binding site
487521009182	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
487521009183	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
487521009184	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521009185	active site
487521009186	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
487521009187	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
487521009188	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
487521009189	Protein export membrane protein; Region: SecD_SecF; pfam02355
487521009190	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
487521009191	Protein export membrane protein; Region: SecD_SecF; cl14618
487521009192	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
487521009193	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
487521009194	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
487521009195	inhibitor-cofactor binding pocket; inhibition site
487521009196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521009197	catalytic residue [active]
487521009198	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
487521009199	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521009200	acyl-activating enzyme (AAE) consensus motif; other site
487521009201	AMP binding site [chemical binding]; other site
487521009202	active site
487521009203	CoA binding site [chemical binding]; other site
487521009204	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521009205	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
487521009206	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
487521009207	putative NAD(P) binding site [chemical binding]; other site
487521009208	active site
487521009209	putative substrate binding site [chemical binding]; other site
487521009210	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
487521009211	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
487521009212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521009213	Walker A motif; other site
487521009214	ATP binding site [chemical binding]; other site
487521009215	Walker B motif; other site
487521009216	arginine finger; other site
487521009217	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
487521009218	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
487521009219	RuvA N terminal domain; Region: RuvA_N; pfam01330
487521009220	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
487521009221	active site
487521009222	putative DNA-binding cleft [nucleotide binding]; other site
487521009223	dimer interface [polypeptide binding]; other site
487521009224	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
487521009225	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
487521009226	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
487521009227	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
487521009228	spermidine synthase; Provisional; Region: PRK03612
487521009229	Spermine/spermidine synthase; Region: Spermine_synth; pfam01564
487521009230	hypothetical protein; Validated; Region: PRK00110
487521009231	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
487521009232	predicted active site [active]
487521009233	catalytic triad [active]
487521009234	acyl-CoA thioesterase II; Region: tesB; TIGR00189
487521009235	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
487521009236	active site
487521009237	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
487521009238	catalytic triad [active]
487521009239	dimer interface [polypeptide binding]; other site
487521009240	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
487521009241	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
487521009242	active site
487521009243	multimer interface [polypeptide binding]; other site
487521009244	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
487521009245	nudix motif; other site
487521009246	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521009247	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521009248	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
487521009249	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
487521009250	putative acyl-acceptor binding pocket; other site
487521009251	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
487521009252	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
487521009253	nucleotide binding site/active site [active]
487521009254	HIT family signature motif; other site
487521009255	catalytic residue [active]
487521009256	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
487521009257	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
487521009258	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
487521009259	active site
487521009260	dimer interface [polypeptide binding]; other site
487521009261	motif 1; other site
487521009262	motif 2; other site
487521009263	motif 3; other site
487521009264	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
487521009265	anticodon binding site; other site
487521009266	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
487521009267	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521009268	CoenzymeA binding site [chemical binding]; other site
487521009269	subunit interaction site [polypeptide binding]; other site
487521009270	PHB binding site; other site
487521009271	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521009272	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521009273	active site
487521009274	catalytic tetrad [active]
487521009275	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
487521009276	Helix-turn-helix domain; Region: HTH_20; pfam12840
487521009277	Predicted transcriptional regulator [Transcription]; Region: COG2345
487521009278	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521009279	FMN binding site [chemical binding]; other site
487521009280	substrate binding site [chemical binding]; other site
487521009281	putative catalytic residue [active]
487521009282	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
487521009283	Predicted transcriptional regulator [Transcription]; Region: COG2345
487521009284	Helix-turn-helix domain; Region: HTH_20; pfam12840
487521009285	putative DNA binding site [nucleotide binding]; other site
487521009286	putative Zn2+ binding site [ion binding]; other site
487521009287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521009288	S-adenosylmethionine binding site [chemical binding]; other site
487521009289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521009290	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
487521009291	tetramer interface [polypeptide binding]; other site
487521009292	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
487521009293	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
487521009294	active site
487521009295	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
487521009296	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
487521009297	active site
487521009298	Hemerythrin-like domain; Region: Hr-like; cd12108
487521009299	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
487521009300	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521009301	iron-sulfur cluster [ion binding]; other site
487521009302	[2Fe-2S] cluster binding site [ion binding]; other site
487521009303	Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535
487521009304	alpha subunit interaction site [polypeptide binding]; other site
487521009305	beta subunit interaction site [polypeptide binding]; other site
487521009306	iron-sulfur cluster [ion binding]; other site
487521009307	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
487521009308	beta subunit interface [polypeptide binding]; other site
487521009309	alpha subunit interface [polypeptide binding]; other site
487521009310	active site
487521009311	substrate binding site [chemical binding]; other site
487521009312	Fe binding site [ion binding]; other site
487521009313	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
487521009314	inter-subunit interface; other site
487521009315	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
487521009316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521009317	NAD(P) binding site [chemical binding]; other site
487521009318	active site
487521009319	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
487521009320	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
487521009321	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521009322	Bacterial transcriptional regulator; Region: IclR; pfam01614
487521009323	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
487521009324	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
487521009325	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521009326	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521009327	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521009328	anti sigma factor interaction site; other site
487521009329	regulatory phosphorylation site [posttranslational modification]; other site
487521009330	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
487521009331	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
487521009332	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
487521009333	putative heme binding pocket [chemical binding]; other site
487521009334	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521009335	classical (c) SDRs; Region: SDR_c; cd05233
487521009336	NAD(P) binding site [chemical binding]; other site
487521009337	active site
487521009338	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
487521009339	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521009340	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521009341	acyl-activating enzyme (AAE) consensus motif; other site
487521009342	putative AMP binding site [chemical binding]; other site
487521009343	putative active site [active]
487521009344	putative CoA binding site [chemical binding]; other site
487521009345	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487521009346	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
487521009347	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521009348	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521009349	substrate binding site [chemical binding]; other site
487521009350	oxyanion hole (OAH) forming residues; other site
487521009351	trimer interface [polypeptide binding]; other site
487521009352	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521009353	hydrophobic ligand binding site; other site
487521009354	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521009355	Phage terminase, small subunit; Region: Terminase_4; cl01525
487521009356	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
487521009357	Phage capsid family; Region: Phage_capsid; pfam05065
487521009358	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
487521009359	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
487521009360	AAA domain; Region: AAA_25; pfam13481
487521009361	Walker B motif; other site
487521009362	Helix-turn-helix domain; Region: HTH_17; cl17695
487521009363	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521009364	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
487521009365	active site
487521009366	catalytic residues [active]
487521009367	DNA binding site [nucleotide binding]
487521009368	Int/Topo IB signature motif; other site
487521009369	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
487521009370	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521009371	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521009372	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
487521009373	classical (c) SDRs; Region: SDR_c; cd05233
487521009374	NAD(P) binding site [chemical binding]; other site
487521009375	active site
487521009376	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521009377	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
487521009378	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521009379	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
487521009380	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521009381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521009382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521009383	short chain dehydrogenase; Provisional; Region: PRK12827
487521009384	classical (c) SDRs; Region: SDR_c; cd05233
487521009385	NAD(P) binding site [chemical binding]; other site
487521009386	active site
487521009387	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521009388	classical (c) SDRs; Region: SDR_c; cd05233
487521009389	NAD(P) binding site [chemical binding]; other site
487521009390	active site
487521009391	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
487521009392	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
487521009393	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521009394	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
487521009395	NAD(P) binding site [chemical binding]; other site
487521009396	catalytic residues [active]
487521009397	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
487521009398	Cation efflux family; Region: Cation_efflux; cl00316
487521009399	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521009400	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521009401	Clp amino terminal domain; Region: Clp_N; pfam02861
487521009402	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521009403	Coenzyme A binding pocket [chemical binding]; other site
487521009404	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
487521009405	hypothetical protein; Provisional; Region: PRK14059
487521009406	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
487521009407	TAP-like protein; Region: Abhydrolase_4; pfam08386
487521009408	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
487521009409	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
487521009410	SelR domain; Region: SelR; pfam01641
487521009411	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521009412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521009413	S-adenosylmethionine binding site [chemical binding]; other site
487521009414	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
487521009415	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
487521009416	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521009417	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
487521009418	substrate binding site [chemical binding]; other site
487521009419	active site
487521009420	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521009421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521009422	substrate binding site [chemical binding]; other site
487521009423	oxyanion hole (OAH) forming residues; other site
487521009424	trimer interface [polypeptide binding]; other site
487521009425	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
487521009426	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
487521009427	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
487521009428	catalytic site [active]
487521009429	putative active site [active]
487521009430	putative substrate binding site [chemical binding]; other site
487521009431	Helicase and RNase D C-terminal; Region: HRDC; smart00341
487521009432	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
487521009433	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
487521009434	TPP-binding site; other site
487521009435	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
487521009436	PYR/PP interface [polypeptide binding]; other site
487521009437	dimer interface [polypeptide binding]; other site
487521009438	TPP binding site [chemical binding]; other site
487521009439	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
487521009440	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
487521009441	FOG: CBS domain [General function prediction only]; Region: COG0517
487521009442	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
487521009443	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
487521009444	transmembrane helices; other site
487521009445	TRAM domain; Region: TRAM; pfam01938
487521009446	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
487521009447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521009448	NAD(P) binding site [chemical binding]; other site
487521009449	active site
487521009450	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
487521009451	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
487521009452	TrkA-N domain; Region: TrkA_N; pfam02254
487521009453	TrkA-C domain; Region: TrkA_C; pfam02080
487521009454	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
487521009455	TrkA-N domain; Region: TrkA_N; pfam02254
487521009456	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
487521009457	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
487521009458	generic binding surface II; other site
487521009459	ssDNA binding site; other site
487521009460	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
487521009461	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
487521009462	trimer interface [polypeptide binding]; other site
487521009463	active site
487521009464	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
487521009465	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
487521009466	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
487521009467	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
487521009468	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
487521009469	active site
487521009470	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487521009471	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521009472	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
487521009473	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521009474	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
487521009475	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521009476	DNA binding residues [nucleotide binding]
487521009477	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
487521009478	homotrimer interaction site [polypeptide binding]; other site
487521009479	putative active site [active]
487521009480	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
487521009481	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
487521009482	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
487521009483	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
487521009484	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
487521009485	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521009486	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
487521009487	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521009488	DNA binding residues [nucleotide binding]
487521009489	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
487521009490	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
487521009491	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
487521009492	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
487521009493	Integrase core domain; Region: rve; pfam00665
487521009494	Integrase core domain; Region: rve_3; pfam13683
487521009495	Homeodomain-like domain; Region: HTH_23; cl17451
487521009496	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
487521009497	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
487521009498	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521009499	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521009500	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487521009501	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
487521009502	PAC2 family; Region: PAC2; pfam09754
487521009503	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521009504	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
487521009505	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
487521009506	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
487521009507	heme-binding site [chemical binding]; other site
487521009508	Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327
487521009509	ATP cone domain; Region: ATP-cone; pfam03477
487521009510	LexA repressor; Validated; Region: PRK00215
487521009511	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
487521009512	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
487521009513	Catalytic site [active]
487521009514	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
487521009515	LGFP repeat; Region: LGFP; pfam08310
487521009516	LGFP repeat; Region: LGFP; pfam08310
487521009517	LGFP repeat; Region: LGFP; pfam08310
487521009518	LGFP repeat; Region: LGFP; pfam08310
487521009519	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521009520	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521009521	active site
487521009522	GTPases [General function prediction only]; Region: HflX; COG2262
487521009523	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
487521009524	HflX GTPase family; Region: HflX; cd01878
487521009525	G1 box; other site
487521009526	GTP/Mg2+ binding site [chemical binding]; other site
487521009527	Switch I region; other site
487521009528	G2 box; other site
487521009529	G3 box; other site
487521009530	Switch II region; other site
487521009531	G4 box; other site
487521009532	G5 box; other site
487521009533	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
487521009534	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
487521009535	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
487521009536	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
487521009537	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
487521009538	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
487521009539	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
487521009540	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
487521009541	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
487521009542	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
487521009543	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521009544	FeS/SAM binding site; other site
487521009545	recombination regulator RecX; Reviewed; Region: recX; PRK00117
487521009546	recombinase A; Provisional; Region: recA; PRK09354
487521009547	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
487521009548	hexamer interface [polypeptide binding]; other site
487521009549	Walker A motif; other site
487521009550	ATP binding site [chemical binding]; other site
487521009551	Walker B motif; other site
487521009552	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
487521009553	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
487521009554	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
487521009555	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
487521009556	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
487521009557	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
487521009558	Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858
487521009559	PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674
487521009560	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
487521009561	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521009562	non-specific DNA binding site [nucleotide binding]; other site
487521009563	salt bridge; other site
487521009564	sequence-specific DNA binding site [nucleotide binding]; other site
487521009565	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
487521009566	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521009567	Coenzyme A binding pocket [chemical binding]; other site
487521009568	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
487521009569	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
487521009570	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521009571	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
487521009572	Uncharacterized conserved protein [Function unknown]; Region: COG1359
487521009573	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
487521009574	classical (c) SDRs; Region: SDR_c; cd05233
487521009575	NAD(P) binding site [chemical binding]; other site
487521009576	active site
487521009577	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521009578	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521009579	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
487521009580	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521009581	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
487521009582	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487521009583	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
487521009584	dimer interface [polypeptide binding]; other site
487521009585	active site
487521009586	catalytic residue [active]
487521009587	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
487521009588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
487521009589	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
487521009590	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
487521009591	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
487521009592	folate binding site [chemical binding]; other site
487521009593	NADP+ binding site [chemical binding]; other site
487521009594	thymidylate synthase; Reviewed; Region: thyA; PRK01827
487521009595	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
487521009596	dimerization interface [polypeptide binding]; other site
487521009597	active site
487521009598	Dienelactone hydrolase family; Region: DLH; pfam01738
487521009599	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521009600	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521009601	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521009602	active site
487521009603	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521009604	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521009605	active site
487521009606	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
487521009607	classical (c) SDRs; Region: SDR_c; cd05233
487521009608	NAD(P) binding site [chemical binding]; other site
487521009609	active site
487521009610	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
487521009611	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487521009612	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521009613	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
487521009614	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
487521009615	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
487521009616	carboxyltransferase (CT) interaction site; other site
487521009617	biotinylation site [posttranslational modification]; other site
487521009618	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
487521009619	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521009620	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521009621	acyl-activating enzyme (AAE) consensus motif; other site
487521009622	AMP binding site [chemical binding]; other site
487521009623	active site
487521009624	CoA binding site [chemical binding]; other site
487521009625	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487521009626	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521009627	CoenzymeA binding site [chemical binding]; other site
487521009628	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
487521009629	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
487521009630	dihydrodipicolinate reductase; Provisional; Region: PRK00048
487521009631	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487521009632	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
487521009633	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521009634	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
487521009635	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521009636	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521009637	iron-sulfur cluster [ion binding]; other site
487521009638	[2Fe-2S] cluster binding site [ion binding]; other site
487521009639	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
487521009640	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
487521009641	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
487521009642	FMN-binding pocket [chemical binding]; other site
487521009643	flavin binding motif; other site
487521009644	phosphate binding motif [ion binding]; other site
487521009645	beta-alpha-beta structure motif; other site
487521009646	NAD binding pocket [chemical binding]; other site
487521009647	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521009648	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
487521009649	catalytic loop [active]
487521009650	iron binding site [ion binding]; other site
487521009651	short chain dehydrogenase; Validated; Region: PRK05855
487521009652	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521009653	classical (c) SDRs; Region: SDR_c; cd05233
487521009654	NAD(P) binding site [chemical binding]; other site
487521009655	active site
487521009656	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
487521009657	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
487521009658	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521009659	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521009660	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521009661	hydrophobic ligand binding site; other site
487521009662	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
487521009663	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
487521009664	hexamer interface [polypeptide binding]; other site
487521009665	ligand binding site [chemical binding]; other site
487521009666	putative active site [active]
487521009667	NAD(P) binding site [chemical binding]; other site
487521009668	Nitronate monooxygenase; Region: NMO; pfam03060
487521009669	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521009670	FMN binding site [chemical binding]; other site
487521009671	substrate binding site [chemical binding]; other site
487521009672	putative catalytic residue [active]
487521009673	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
487521009674	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
487521009675	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
487521009676	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
487521009677	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
487521009678	oligomer interface [polypeptide binding]; other site
487521009679	RNA binding site [nucleotide binding]; other site
487521009680	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
487521009681	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
487521009682	RNase E interface [polypeptide binding]; other site
487521009683	trimer interface [polypeptide binding]; other site
487521009684	active site
487521009685	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
487521009686	putative nucleic acid binding region [nucleotide binding]; other site
487521009687	G-X-X-G motif; other site
487521009688	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
487521009689	RNA binding site [nucleotide binding]; other site
487521009690	domain interface; other site
487521009691	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
487521009692	16S/18S rRNA binding site [nucleotide binding]; other site
487521009693	S13e-L30e interaction site [polypeptide binding]; other site
487521009694	25S rRNA binding site [nucleotide binding]; other site
487521009695	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521009696	dimerization interface [polypeptide binding]; other site
487521009697	putative DNA binding site [nucleotide binding]; other site
487521009698	putative Zn2+ binding site [ion binding]; other site
487521009699	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
487521009700	putative hydrophobic ligand binding site [chemical binding]; other site
487521009701	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
487521009702	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
487521009703	active site
487521009704	Riboflavin kinase; Region: Flavokinase; pfam01687
487521009705	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
487521009706	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521009707	putative DNA binding site [nucleotide binding]; other site
487521009708	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
487521009709	FeoA domain; Region: FeoA; pfam04023
487521009710	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521009711	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521009712	active site
487521009713	lipid-transfer protein; Provisional; Region: PRK08256
487521009714	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521009715	active site
487521009716	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
487521009717	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
487521009718	RNA binding site [nucleotide binding]; other site
487521009719	active site
487521009720	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
487521009721	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
487521009722	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
487521009723	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
487521009724	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
487521009725	active site
487521009726	metal binding site [ion binding]; metal-binding site
487521009727	Predicted acyl esterases [General function prediction only]; Region: COG2936
487521009728	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
487521009729	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
487521009730	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
487521009731	enoyl-CoA hydratase; Provisional; Region: PRK06190
487521009732	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521009733	substrate binding site [chemical binding]; other site
487521009734	oxyanion hole (OAH) forming residues; other site
487521009735	trimer interface [polypeptide binding]; other site
487521009736	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
487521009737	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
487521009738	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
487521009739	DHH family; Region: DHH; pfam01368
487521009740	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
487521009741	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
487521009742	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
487521009743	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
487521009744	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
487521009745	G1 box; other site
487521009746	putative GEF interaction site [polypeptide binding]; other site
487521009747	GTP/Mg2+ binding site [chemical binding]; other site
487521009748	Switch I region; other site
487521009749	G2 box; other site
487521009750	G3 box; other site
487521009751	Switch II region; other site
487521009752	G4 box; other site
487521009753	G5 box; other site
487521009754	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
487521009755	Translation-initiation factor 2; Region: IF-2; pfam11987
487521009756	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
487521009757	Protein of unknown function (DUF448); Region: DUF448; pfam04296
487521009758	putative RNA binding cleft [nucleotide binding]; other site
487521009759	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
487521009760	NusA N-terminal domain; Region: NusA_N; pfam08529
487521009761	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
487521009762	RNA binding site [nucleotide binding]; other site
487521009763	homodimer interface [polypeptide binding]; other site
487521009764	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
487521009765	G-X-X-G motif; other site
487521009766	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
487521009767	G-X-X-G motif; other site
487521009768	ribosome maturation protein RimP; Reviewed; Region: PRK00092
487521009769	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
487521009770	putative oligomer interface [polypeptide binding]; other site
487521009771	putative RNA binding site [nucleotide binding]; other site
487521009772	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
487521009773	dinuclear metal binding motif [ion binding]; other site
487521009774	prolyl-tRNA synthetase; Provisional; Region: PRK09194
487521009775	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
487521009776	dimer interface [polypeptide binding]; other site
487521009777	motif 1; other site
487521009778	active site
487521009779	motif 2; other site
487521009780	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
487521009781	putative deacylase active site [active]
487521009782	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
487521009783	active site
487521009784	motif 3; other site
487521009785	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
487521009786	anticodon binding site; other site
487521009787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521009788	putative substrate translocation pore; other site
487521009789	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
487521009790	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
487521009791	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
487521009792	active site
487521009793	SAM binding site [chemical binding]; other site
487521009794	homodimer interface [polypeptide binding]; other site
487521009795	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
487521009796	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
487521009797	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
487521009798	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
487521009799	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
487521009800	Walker A motif; other site
487521009801	homodimer interface [polypeptide binding]; other site
487521009802	ATP binding site [chemical binding]; other site
487521009803	hydroxycobalamin binding site [chemical binding]; other site
487521009804	Walker B motif; other site
487521009805	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
487521009806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521009807	Walker A motif; other site
487521009808	ATP binding site [chemical binding]; other site
487521009809	Walker B motif; other site
487521009810	arginine finger; other site
487521009811	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
487521009812	metal ion-dependent adhesion site (MIDAS); other site
487521009813	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
487521009814	Coenzyme A binding pocket [chemical binding]; other site
487521009815	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
487521009816	malate:quinone oxidoreductase; Validated; Region: PRK05257
487521009817	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
487521009818	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521009819	mycothione reductase; Reviewed; Region: PRK07846
487521009820	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521009821	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521009822	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487521009823	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
487521009824	Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068
487521009825	nickel binding site [ion binding]; other site
487521009826	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
487521009827	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
487521009828	Uncharacterized conserved protein [Function unknown]; Region: COG3379
487521009829	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521009830	PPE family; Region: PPE; pfam00823
487521009831	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
487521009832	classical (c) SDRs; Region: SDR_c; cd05233
487521009833	NAD(P) binding site [chemical binding]; other site
487521009834	active site
487521009835	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521009836	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
487521009837	NAD(P) binding site [chemical binding]; other site
487521009838	catalytic residues [active]
487521009839	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
487521009840	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
487521009841	catalytic triad [active]
487521009842	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
487521009843	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
487521009844	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521009845	cobyric acid synthase; Provisional; Region: PRK00784
487521009846	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
487521009847	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
487521009848	catalytic triad [active]
487521009849	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
487521009850	active site
487521009851	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
487521009852	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
487521009853	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
487521009854	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
487521009855	Predicted acetyltransferase [General function prediction only]; Region: COG3393
487521009856	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
487521009857	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
487521009858	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
487521009859	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
487521009860	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
487521009861	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
487521009862	active site
487521009863	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
487521009864	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
487521009865	putative substrate binding region [chemical binding]; other site
487521009866	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
487521009867	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
487521009868	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
487521009869	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
487521009870	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
487521009871	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
487521009872	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487521009873	catalytic residues [active]
487521009874	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
487521009875	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521009876	FeS/SAM binding site; other site
487521009877	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
487521009878	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
487521009879	ribosome recycling factor; Reviewed; Region: frr; PRK00083
487521009880	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
487521009881	hinge region; other site
487521009882	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
487521009883	putative nucleotide binding site [chemical binding]; other site
487521009884	uridine monophosphate binding site [chemical binding]; other site
487521009885	homohexameric interface [polypeptide binding]; other site
487521009886	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521009887	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521009888	DNA binding site [nucleotide binding]
487521009889	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521009890	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
487521009891	putative acyl-acceptor binding pocket; other site
487521009892	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
487521009893	short chain dehydrogenase; Provisional; Region: PRK06701
487521009894	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521009895	NAD(P) binding site [chemical binding]; other site
487521009896	active site
487521009897	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
487521009898	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
487521009899	Moco binding site; other site
487521009900	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
487521009901	metal coordination site [ion binding]; other site
487521009902	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
487521009903	ChaB; Region: ChaB; pfam06150
487521009904	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
487521009905	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521009906	MarR family; Region: MarR; pfam01047
487521009907	amidase; Provisional; Region: PRK07869
487521009908	Amidase; Region: Amidase; pfam01425
487521009909	elongation factor Ts; Provisional; Region: tsf; PRK09377
487521009910	UBA/TS-N domain; Region: UBA; pfam00627
487521009911	Elongation factor TS; Region: EF_TS; pfam00889
487521009912	Elongation factor TS; Region: EF_TS; pfam00889
487521009913	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
487521009914	rRNA interaction site [nucleotide binding]; other site
487521009915	S8 interaction site; other site
487521009916	putative laminin-1 binding site; other site
487521009917	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
487521009918	Peptidase family M23; Region: Peptidase_M23; pfam01551
487521009919	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
487521009920	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521009921	active site
487521009922	DNA binding site [nucleotide binding]
487521009923	Int/Topo IB signature motif; other site
487521009924	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
487521009925	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
487521009926	putative active site [active]
487521009927	putative substrate binding site [chemical binding]; other site
487521009928	putative FMN binding site [chemical binding]; other site
487521009929	putative catalytic residues [active]
487521009930	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
487521009931	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
487521009932	FAD binding pocket [chemical binding]; other site
487521009933	FAD binding motif [chemical binding]; other site
487521009934	phosphate binding motif [ion binding]; other site
487521009935	NAD binding pocket [chemical binding]; other site
487521009936	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
487521009937	DNA protecting protein DprA; Region: dprA; TIGR00732
487521009938	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
487521009939	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
487521009940	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
487521009941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521009942	Walker A motif; other site
487521009943	ATP binding site [chemical binding]; other site
487521009944	Walker B motif; other site
487521009945	arginine finger; other site
487521009946	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
487521009947	hypothetical protein; Reviewed; Region: PRK12497
487521009948	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
487521009949	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
487521009950	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
487521009951	putative molybdopterin cofactor binding site [chemical binding]; other site
487521009952	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
487521009953	putative molybdopterin cofactor binding site; other site
487521009954	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521009955	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
487521009956	NAD(P) binding site [chemical binding]; other site
487521009957	active site
487521009958	ANTAR domain; Region: ANTAR; pfam03861
487521009959	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
487521009960	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
487521009961	RNA/DNA hybrid binding site [nucleotide binding]; other site
487521009962	active site
487521009963	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
487521009964	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
487521009965	Catalytic site [active]
487521009966	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
487521009967	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
487521009968	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
487521009969	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
487521009970	RimM N-terminal domain; Region: RimM; pfam01782
487521009971	PRC-barrel domain; Region: PRC; pfam05239
487521009972	hypothetical protein; Provisional; Region: PRK02821
487521009973	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
487521009974	G-X-X-G motif; other site
487521009975	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
487521009976	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
487521009977	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
487521009978	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
487521009979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521009980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521009981	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
487521009982	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521009983	active site
487521009984	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521009985	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
487521009986	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521009987	active site
487521009988	signal recognition particle protein; Provisional; Region: PRK10867
487521009989	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
487521009990	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
487521009991	P loop; other site
487521009992	GTP binding site [chemical binding]; other site
487521009993	Signal peptide binding domain; Region: SRP_SPB; pfam02978
487521009994	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521009995	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
487521009996	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
487521009997	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521009998	ATP binding site [chemical binding]; other site
487521009999	putative Mg++ binding site [ion binding]; other site
487521010000	Homeodomain-like domain; Region: HTH_23; cl17451
487521010001	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
487521010002	Integrase core domain; Region: rve; pfam00665
487521010003	Integrase core domain; Region: rve_3; pfam13683
487521010004	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521010005	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521010006	active site
487521010007	PII uridylyl-transferase; Provisional; Region: PRK03381
487521010008	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
487521010009	metal binding triad; other site
487521010010	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
487521010011	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
487521010012	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
487521010013	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
487521010014	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
487521010015	Nitrogen regulatory protein P-II; Region: P-II; smart00938
487521010016	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
487521010017	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
487521010018	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
487521010019	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
487521010020	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
487521010021	AAA domain; Region: AAA_23; pfam13476
487521010022	Walker A/P-loop; other site
487521010023	ATP binding site [chemical binding]; other site
487521010024	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
487521010025	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
487521010026	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
487521010027	ABC transporter signature motif; other site
487521010028	Walker B; other site
487521010029	D-loop; other site
487521010030	H-loop/switch region; other site
487521010031	acylphosphatase; Provisional; Region: PRK14422
487521010032	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
487521010033	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
487521010034	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
487521010035	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
487521010036	DNA binding site [nucleotide binding]
487521010037	catalytic residue [active]
487521010038	H2TH interface [polypeptide binding]; other site
487521010039	putative catalytic residues [active]
487521010040	turnover-facilitating residue; other site
487521010041	intercalation triad [nucleotide binding]; other site
487521010042	8OG recognition residue [nucleotide binding]; other site
487521010043	putative reading head residues; other site
487521010044	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
487521010045	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
487521010046	ribonuclease III; Reviewed; Region: rnc; PRK00102
487521010047	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
487521010048	dimerization interface [polypeptide binding]; other site
487521010049	active site
487521010050	metal binding site [ion binding]; metal-binding site
487521010051	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
487521010052	dsRNA binding site [nucleotide binding]; other site
487521010053	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
487521010054	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
487521010055	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
487521010056	Predicted permease; Region: DUF318; pfam03773
487521010057	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
487521010058	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487521010059	PYR/PP interface [polypeptide binding]; other site
487521010060	dimer interface [polypeptide binding]; other site
487521010061	TPP binding site [chemical binding]; other site
487521010062	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521010063	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
487521010064	TPP-binding site [chemical binding]; other site
487521010065	dimer interface [polypeptide binding]; other site
487521010066	Lysozyme family protein [General function prediction only]; Region: COG5526
487521010067	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
487521010068	(T/H)XGH motif; other site
487521010069	pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510
487521010070	active site
487521010071	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
487521010072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521010073	S-adenosylmethionine binding site [chemical binding]; other site
487521010074	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
487521010075	putative active site [active]
487521010076	redox center [active]
487521010077	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
487521010078	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
487521010079	catalytic residues [active]
487521010080	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521010081	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521010082	substrate binding pocket [chemical binding]; other site
487521010083	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521010084	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521010085	active site
487521010086	catalytic tetrad [active]
487521010087	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
487521010088	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
487521010089	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
487521010090	ssDNA binding site; other site
487521010091	generic binding surface II; other site
487521010092	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521010093	ATP binding site [chemical binding]; other site
487521010094	putative Mg++ binding site [ion binding]; other site
487521010095	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521010096	nucleotide binding region [chemical binding]; other site
487521010097	ATP-binding site [chemical binding]; other site
487521010098	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
487521010099	DAK2 domain; Region: Dak2; cl03685
487521010100	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
487521010101	N-acetyl-D-glucosamine binding site [chemical binding]; other site
487521010102	catalytic residue [active]
487521010103	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
487521010104	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521010105	classical (c) SDRs; Region: SDR_c; cd05233
487521010106	NAD(P) binding site [chemical binding]; other site
487521010107	active site
487521010108	short chain dehydrogenase; Provisional; Region: PRK06197
487521010109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010110	NAD(P) binding site [chemical binding]; other site
487521010111	active site
487521010112	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
487521010113	short chain dehydrogenase; Provisional; Region: PRK06180
487521010114	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
487521010115	NADP binding site [chemical binding]; other site
487521010116	active site
487521010117	steroid binding site; other site
487521010118	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
487521010119	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
487521010120	putative NAD(P) binding site [chemical binding]; other site
487521010121	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
487521010122	ligand binding site [chemical binding]; other site
487521010123	active site
487521010124	UGI interface [polypeptide binding]; other site
487521010125	catalytic site [active]
487521010126	thiamine monophosphate kinase; Provisional; Region: PRK05731
487521010127	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
487521010128	ATP binding site [chemical binding]; other site
487521010129	dimerization interface [polypeptide binding]; other site
487521010130	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
487521010131	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
487521010132	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
487521010133	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
487521010134	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
487521010135	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
487521010136	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
487521010137	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
487521010138	polyphosphate kinase; Provisional; Region: PRK05443
487521010139	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
487521010140	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
487521010141	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
487521010142	putative domain interface [polypeptide binding]; other site
487521010143	putative active site [active]
487521010144	catalytic site [active]
487521010145	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
487521010146	putative domain interface [polypeptide binding]; other site
487521010147	putative active site [active]
487521010148	catalytic site [active]
487521010149	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
487521010150	active site
487521010151	Ap6A binding site [chemical binding]; other site
487521010152	nudix motif; other site
487521010153	metal binding site [ion binding]; metal-binding site
487521010154	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521010155	catalytic core [active]
487521010156	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
487521010157	IHF - DNA interface [nucleotide binding]; other site
487521010158	IHF dimer interface [polypeptide binding]; other site
487521010159	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
487521010160	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
487521010161	substrate binding site [chemical binding]; other site
487521010162	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
487521010163	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
487521010164	substrate binding site [chemical binding]; other site
487521010165	ligand binding site [chemical binding]; other site
487521010166	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
487521010167	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521010168	Bacterial transcriptional regulator; Region: IclR; pfam01614
487521010169	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521010170	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
487521010171	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487521010172	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
487521010173	active site
487521010174	KMSKS motif; other site
487521010175	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
487521010176	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
487521010177	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
487521010178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521010179	Major Facilitator Superfamily; Region: MFS_1; pfam07690
487521010180	putative substrate translocation pore; other site
487521010181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521010182	Major Facilitator Superfamily; Region: MFS_1; pfam07690
487521010183	putative substrate translocation pore; other site
487521010184	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
487521010185	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
487521010186	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
487521010187	ligand binding site [chemical binding]; other site
487521010188	NAD binding site [chemical binding]; other site
487521010189	dimerization interface [polypeptide binding]; other site
487521010190	catalytic site [active]
487521010191	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
487521010192	putative L-serine binding site [chemical binding]; other site
487521010193	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
487521010194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521010195	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
487521010196	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
487521010197	ketol-acid reductoisomerase; Provisional; Region: PRK05479
487521010198	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
487521010199	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
487521010200	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
487521010201	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
487521010202	putative valine binding site [chemical binding]; other site
487521010203	dimer interface [polypeptide binding]; other site
487521010204	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
487521010205	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
487521010206	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487521010207	PYR/PP interface [polypeptide binding]; other site
487521010208	dimer interface [polypeptide binding]; other site
487521010209	TPP binding site [chemical binding]; other site
487521010210	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521010211	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
487521010212	TPP-binding site [chemical binding]; other site
487521010213	dimer interface [polypeptide binding]; other site
487521010214	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
487521010215	Predicted membrane protein [Function unknown]; Region: COG2259
487521010216	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
487521010217	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
487521010218	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
487521010219	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
487521010220	GatB domain; Region: GatB_Yqey; smart00845
487521010221	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
487521010222	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
487521010223	P-loop; other site
487521010224	Magnesium ion binding site [ion binding]; other site
487521010225	6-phosphofructokinase; Provisional; Region: PRK03202
487521010226	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
487521010227	active site
487521010228	ADP/pyrophosphate binding site [chemical binding]; other site
487521010229	dimerization interface [polypeptide binding]; other site
487521010230	allosteric effector site; other site
487521010231	fructose-1,6-bisphosphate binding site; other site
487521010232	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
487521010233	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
487521010234	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
487521010235	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
487521010236	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521010237	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521010238	active site
487521010239	Transposase; Region: HTH_Tnp_1; cl17663
487521010240	putative transposase OrfB; Reviewed; Region: PHA02517
487521010241	HTH-like domain; Region: HTH_21; pfam13276
487521010242	Integrase core domain; Region: rve; pfam00665
487521010243	Integrase core domain; Region: rve_3; pfam13683
487521010244	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521010245	potential frameshift: common BLAST hit: gi|224989953|ref|YP_002644640.1| transmembrane transport protein
487521010246	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
487521010247	MMPL family; Region: MMPL; pfam03176
487521010248	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521010249	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
487521010250	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010251	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521010252	cystathionine gamma-lyase; Validated; Region: PRK07582
487521010253	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
487521010254	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521010255	catalytic residue [active]
487521010256	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
487521010257	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
487521010258	nucleotide binding pocket [chemical binding]; other site
487521010259	K-X-D-G motif; other site
487521010260	catalytic site [active]
487521010261	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
487521010262	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
487521010263	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
487521010264	Dimer interface [polypeptide binding]; other site
487521010265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487521010266	putative DNA binding site [nucleotide binding]; other site
487521010267	putative Zn2+ binding site [ion binding]; other site
487521010268	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
487521010269	putative hydrophobic ligand binding site [chemical binding]; other site
487521010270	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
487521010271	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521010272	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
487521010273	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
487521010274	Ligand Binding Site [chemical binding]; other site
487521010275	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
487521010276	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
487521010277	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487521010278	catalytic residue [active]
487521010279	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521010280	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
487521010281	putative acyl-acceptor binding pocket; other site
487521010282	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
487521010283	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
487521010284	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
487521010285	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
487521010286	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
487521010287	Ligand binding site [chemical binding]; other site
487521010288	Electron transfer flavoprotein domain; Region: ETF; pfam01012
487521010289	Methyltransferase domain; Region: Methyltransf_23; pfam13489
487521010290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521010291	S-adenosylmethionine binding site [chemical binding]; other site
487521010292	Uncharacterized conserved protein [Function unknown]; Region: COG1543
487521010293	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
487521010294	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
487521010295	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521010296	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521010297	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
487521010298	putative hydrophobic ligand binding site [chemical binding]; other site
487521010299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010300	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
487521010301	NAD(P) binding site [chemical binding]; other site
487521010302	active site
487521010303	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521010304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010305	NAD(P) binding site [chemical binding]; other site
487521010306	active site
487521010307	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521010308	anti sigma factor interaction site; other site
487521010309	regulatory phosphorylation site [posttranslational modification]; other site
487521010310	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
487521010311	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
487521010312	substrate binding pocket [chemical binding]; other site
487521010313	chain length determination region; other site
487521010314	substrate-Mg2+ binding site; other site
487521010315	catalytic residues [active]
487521010316	aspartate-rich region 1; other site
487521010317	active site lid residues [active]
487521010318	aspartate-rich region 2; other site
487521010319	phytoene desaturase; Region: crtI_fam; TIGR02734
487521010320	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
487521010321	active site lid residues [active]
487521010322	substrate binding pocket [chemical binding]; other site
487521010323	catalytic residues [active]
487521010324	substrate-Mg2+ binding site; other site
487521010325	aspartate-rich region 1; other site
487521010326	aspartate-rich region 2; other site
487521010327	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
487521010328	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
487521010329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521010330	S-adenosylmethionine binding site [chemical binding]; other site
487521010331	Uncharacterized conserved protein [Function unknown]; Region: COG3349
487521010332	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521010333	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
487521010334	[2Fe-2S] cluster binding site [ion binding]; other site
487521010335	iron-sulfur cluster [ion binding]; other site
487521010336	Protein of unknown function (DUF3140); Region: DUF3140; pfam11338
487521010337	Transcriptional regulators [Transcription]; Region: MarR; COG1846
487521010338	MarR family; Region: MarR_2; pfam12802
487521010339	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
487521010340	glycosyltransferase, MGT family; Region: MGT; TIGR01426
487521010341	active site
487521010342	TDP-binding site; other site
487521010343	acceptor substrate-binding pocket; other site
487521010344	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
487521010345	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
487521010346	homotetramer interface [polypeptide binding]; other site
487521010347	FMN binding site [chemical binding]; other site
487521010348	homodimer contacts [polypeptide binding]; other site
487521010349	putative active site [active]
487521010350	putative substrate binding site [chemical binding]; other site
487521010351	MMPL family; Region: MMPL; pfam03176
487521010352	TspO/MBR family; Region: TspO_MBR; pfam03073
487521010353	DNA photolyase; Region: DNA_photolyase; pfam00875
487521010354	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
487521010355	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
487521010356	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
487521010357	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
487521010358	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
487521010359	trimer interface [polypeptide binding]; other site
487521010360	active site
487521010361	substrate binding site [chemical binding]; other site
487521010362	CoA binding site [chemical binding]; other site
487521010363	FOG: WD40-like repeat [Function unknown]; Region: COG1520
487521010364	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
487521010365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521010366	S-adenosylmethionine binding site [chemical binding]; other site
487521010367	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521010368	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521010369	substrate binding site [chemical binding]; other site
487521010370	oxyanion hole (OAH) forming residues; other site
487521010371	trimer interface [polypeptide binding]; other site
487521010372	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
487521010373	nudix motif; other site
487521010374	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
487521010375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521010376	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521010377	Walker A/P-loop; other site
487521010378	Walker A/P-loop; other site
487521010379	ATP binding site [chemical binding]; other site
487521010380	ATP binding site [chemical binding]; other site
487521010381	Q-loop/lid; other site
487521010382	ABC transporter signature motif; other site
487521010383	Walker B; other site
487521010384	D-loop; other site
487521010385	H-loop/switch region; other site
487521010386	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
487521010387	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
487521010388	phosphoserine phosphatase SerB; Region: serB; TIGR00338
487521010389	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521010390	motif II; other site
487521010391	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
487521010392	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
487521010393	D-pathway; other site
487521010394	Putative ubiquinol binding site [chemical binding]; other site
487521010395	Low-spin heme (heme b) binding site [chemical binding]; other site
487521010396	Putative water exit pathway; other site
487521010397	Binuclear center (heme o3/CuB) [ion binding]; other site
487521010398	K-pathway; other site
487521010399	Putative proton exit pathway; other site
487521010400	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
487521010401	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
487521010402	siderophore binding site; other site
487521010403	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
487521010404	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
487521010405	putative NAD(P) binding site [chemical binding]; other site
487521010406	putative substrate binding site [chemical binding]; other site
487521010407	catalytic Zn binding site [ion binding]; other site
487521010408	structural Zn binding site [ion binding]; other site
487521010409	dimer interface [polypeptide binding]; other site
487521010410	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
487521010411	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
487521010412	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
487521010413	dimer interface [polypeptide binding]; other site
487521010414	putative radical transfer pathway; other site
487521010415	diiron center [ion binding]; other site
487521010416	tyrosyl radical; other site
487521010417	Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862
487521010418	putative hydrophobic ligand binding site [chemical binding]; other site
487521010419	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010420	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521010421	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
487521010422	Ligand Binding Site [chemical binding]; other site
487521010423	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521010424	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521010425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521010427	Helix-turn-helix domain; Region: HTH_18; pfam12833
487521010428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521010429	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
487521010430	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
487521010431	Class I ribonucleotide reductase; Region: RNR_I; cd01679
487521010432	active site
487521010433	dimer interface [polypeptide binding]; other site
487521010434	catalytic residues [active]
487521010435	effector binding site; other site
487521010436	R2 peptide binding site; other site
487521010437	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
487521010438	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
487521010439	catalytic residues [active]
487521010440	Predicted flavoprotein [General function prediction only]; Region: COG0431
487521010441	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
487521010442	short chain dehydrogenase; Provisional; Region: PRK07832
487521010443	classical (c) SDRs; Region: SDR_c; cd05233
487521010444	NAD(P) binding site [chemical binding]; other site
487521010445	active site
487521010446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521010448	Cytochrome P450; Region: p450; cl12078
487521010449	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521010450	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
487521010451	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
487521010452	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
487521010453	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
487521010454	Transcriptional regulators [Transcription]; Region: FadR; COG2186
487521010455	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521010456	DNA-binding site [nucleotide binding]; DNA binding site
487521010457	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
487521010458	Transcriptional regulators [Transcription]; Region: FadR; COG2186
487521010459	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
487521010460	DNA-binding site [nucleotide binding]; DNA binding site
487521010461	FCD domain; Region: FCD; pfam07729
487521010462	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521010463	active site
487521010464	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521010465	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521010466	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521010467	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521010468	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521010469	active site
487521010470	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
487521010471	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010472	NAD(P) binding site [chemical binding]; other site
487521010473	active site
487521010474	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
487521010475	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
487521010476	active site
487521010477	DNA binding site [nucleotide binding]
487521010478	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
487521010479	DNA binding site [nucleotide binding]
487521010480	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
487521010481	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
487521010482	nucleotide binding site [chemical binding]; other site
487521010483	putative NEF/HSP70 interaction site [polypeptide binding]; other site
487521010484	SBD interface [polypeptide binding]; other site
487521010485	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
487521010486	FMN binding site [chemical binding]; other site
487521010487	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
487521010488	dimer interface [polypeptide binding]; other site
487521010489	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521010490	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
487521010491	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521010492	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
487521010493	dimer interface [polypeptide binding]; other site
487521010494	active site
487521010495	enoyl-CoA hydratase; Provisional; Region: PRK05864
487521010496	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521010497	substrate binding site [chemical binding]; other site
487521010498	oxyanion hole (OAH) forming residues; other site
487521010499	trimer interface [polypeptide binding]; other site
487521010500	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521010501	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521010502	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521010503	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521010504	active site
487521010505	MspA; Region: MspA; pfam09203
487521010506	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
487521010507	Phosphotransferase enzyme family; Region: APH; pfam01636
487521010508	putative active site [active]
487521010509	putative substrate binding site [chemical binding]; other site
487521010510	ATP binding site [chemical binding]; other site
487521010511	short chain dehydrogenase; Provisional; Region: PRK08278
487521010512	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010513	NAD(P) binding site [chemical binding]; other site
487521010514	active site
487521010515	Predicted membrane protein [Function unknown]; Region: COG2259
487521010516	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521010517	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
487521010518	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521010519	Transport protein; Region: actII; TIGR00833
487521010520	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521010521	classical (c) SDRs; Region: SDR_c; cd05233
487521010522	NAD(P) binding site [chemical binding]; other site
487521010523	active site
487521010524	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521010525	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
487521010526	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
487521010527	substrate binding pocket [chemical binding]; other site
487521010528	active site
487521010529	iron coordination sites [ion binding]; other site
487521010530	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521010531	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521010532	[2Fe-2S] cluster binding site [ion binding]; other site
487521010533	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
487521010534	alpha subunit interface [polypeptide binding]; other site
487521010535	active site
487521010536	substrate binding site [chemical binding]; other site
487521010537	Fe binding site [ion binding]; other site
487521010538	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521010539	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010540	NAD(P) binding site [chemical binding]; other site
487521010541	active site
487521010542	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
487521010543	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
487521010544	FAD binding pocket [chemical binding]; other site
487521010545	FAD binding motif [chemical binding]; other site
487521010546	phosphate binding motif [ion binding]; other site
487521010547	beta-alpha-beta structure motif; other site
487521010548	NAD(p) ribose binding residues [chemical binding]; other site
487521010549	NAD binding pocket [chemical binding]; other site
487521010550	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
487521010551	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521010552	catalytic loop [active]
487521010553	iron binding site [ion binding]; other site
487521010554	MarR family; Region: MarR_2; pfam12802
487521010555	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521010556	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
487521010557	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
487521010558	active site
487521010559	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521010560	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521010561	[2Fe-2S] cluster binding site [ion binding]; other site
487521010562	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
487521010563	alpha subunit interface [polypeptide binding]; other site
487521010564	active site
487521010565	substrate binding site [chemical binding]; other site
487521010566	Fe binding site [ion binding]; other site
487521010567	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521010568	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
487521010569	NAD binding site [chemical binding]; other site
487521010570	catalytic residues [active]
487521010571	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
487521010572	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521010573	acyl-activating enzyme (AAE) consensus motif; other site
487521010574	AMP binding site [chemical binding]; other site
487521010575	active site
487521010576	CoA binding site [chemical binding]; other site
487521010577	Fic/DOC family; Region: Fic; cl00960
487521010578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521010579	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
487521010580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521010581	phosphoglucomutase; Validated; Region: PRK07564
487521010582	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
487521010583	active site
487521010584	substrate binding site [chemical binding]; other site
487521010585	metal binding site [ion binding]; metal-binding site
487521010586	camphor resistance protein CrcB; Provisional; Region: PRK14216
487521010587	camphor resistance protein CrcB; Provisional; Region: PRK14228
487521010588	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
487521010589	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
487521010590	Protein of unknown function, DUF488; Region: DUF488; cl01246
487521010591	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521010592	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521010593	active site
487521010594	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
487521010595	Hemerythrin-like domain; Region: Hr-like; cd12108
487521010596	Fe binding site [ion binding]; other site
487521010597	Uncharacterized conserved protein [Function unknown]; Region: COG0397
487521010598	hypothetical protein; Validated; Region: PRK00029
487521010599	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521010600	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521010601	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
487521010602	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010603	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
487521010604	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521010605	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
487521010606	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
487521010607	putative active site [active]
487521010608	catalytic site [active]
487521010609	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
487521010610	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
487521010611	putative active site [active]
487521010612	putative active site [active]
487521010613	catalytic site [active]
487521010614	catalytic site [active]
487521010615	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
487521010616	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
487521010617	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521010618	Proteins of 100 residues with WXG; Region: WXG100; cl02005
487521010619	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
487521010620	NAD binding site [chemical binding]; other site
487521010621	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521010622	dimerization interface [polypeptide binding]; other site
487521010623	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521010624	cyclase homology domain; Region: CHD; cd07302
487521010625	nucleotidyl binding site; other site
487521010626	metal binding site [ion binding]; metal-binding site
487521010627	dimer interface [polypeptide binding]; other site
487521010628	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
487521010629	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521010630	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
487521010631	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
487521010632	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521010633	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521010634	[2Fe-2S] cluster binding site [ion binding]; other site
487521010635	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
487521010636	alpha subunit interface [polypeptide binding]; other site
487521010637	active site
487521010638	substrate binding site [chemical binding]; other site
487521010639	Fe binding site [ion binding]; other site
487521010640	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487521010641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521010642	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
487521010643	putative effector binding pocket; other site
487521010644	dimerization interface [polypeptide binding]; other site
487521010645	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521010646	phosphopeptide binding site; other site
487521010647	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521010648	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521010649	phosphopeptide binding site; other site
487521010650	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
487521010651	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
487521010652	Walker A/P-loop; other site
487521010653	ATP binding site [chemical binding]; other site
487521010654	Q-loop/lid; other site
487521010655	ABC transporter signature motif; other site
487521010656	Walker B; other site
487521010657	D-loop; other site
487521010658	H-loop/switch region; other site
487521010659	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
487521010660	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521010661	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521010662	active site
487521010663	ATP binding site [chemical binding]; other site
487521010664	substrate binding site [chemical binding]; other site
487521010665	activation loop (A-loop); other site
487521010666	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
487521010667	Galactose oxidase, central domain; Region: Kelch_3; cl02701
487521010668	Kelch domain; Region: Kelch; smart00612
487521010669	Kelch motif; Region: Kelch_1; pfam01344
487521010670	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
487521010671	Kelch motif; Region: Kelch_1; pfam01344
487521010672	Kelch domain; Region: Kelch; smart00612
487521010673	Kelch motif; Region: Kelch_6; pfam13964
487521010674	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
487521010675	Kelch motif; Region: Kelch_1; pfam01344
487521010676	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521010677	Domain of unknown function (DUF385); Region: DUF385; pfam04075
487521010678	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
487521010679	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
487521010680	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
487521010681	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
487521010682	EamA-like transporter family; Region: EamA; pfam00892
487521010683	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
487521010684	SmpB-tmRNA interface; other site
487521010685	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
487521010686	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
487521010687	FtsX-like permease family; Region: FtsX; pfam02687
487521010688	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
487521010689	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487521010690	Walker A/P-loop; other site
487521010691	ATP binding site [chemical binding]; other site
487521010692	Q-loop/lid; other site
487521010693	ABC transporter signature motif; other site
487521010694	Walker B; other site
487521010695	D-loop; other site
487521010696	H-loop/switch region; other site
487521010697	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
487521010698	Mechanosensitive ion channel; Region: MS_channel; pfam00924
487521010699	peptide chain release factor 2; Validated; Region: prfB; PRK00578
487521010700	This domain is found in peptide chain release factors; Region: PCRF; smart00937
487521010701	RF-1 domain; Region: RF-1; pfam00472
487521010702	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
487521010703	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
487521010704	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
487521010705	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
487521010706	Binuclear center (active site) [active]
487521010707	K-pathway; other site
487521010708	Putative proton exit pathway; other site
487521010709	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
487521010710	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
487521010711	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
487521010712	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521010713	PPE family; Region: PPE; pfam00823
487521010714	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521010715	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521010716	PPE family; Region: PPE; pfam00823
487521010717	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521010718	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
487521010719	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
487521010720	active site
487521010721	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521010722	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521010723	active site
487521010724	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521010725	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521010726	active site
487521010727	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521010728	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521010729	active site
487521010730	catalytic tetrad [active]
487521010731	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
487521010732	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
487521010733	NADP binding site [chemical binding]; other site
487521010734	dimer interface [polypeptide binding]; other site
487521010735	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
487521010736	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
487521010737	NAD(P) binding site [chemical binding]; other site
487521010738	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
487521010739	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521010740	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
487521010741	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521010742	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521010743	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
487521010744	active site
487521010745	catalytic residues [active]
487521010746	metal binding site [ion binding]; metal-binding site
487521010747	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010748	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521010749	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521010750	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521010751	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521010752	active site
487521010753	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
487521010754	Phosphotransferase enzyme family; Region: APH; pfam01636
487521010755	putative active site [active]
487521010756	putative substrate binding site [chemical binding]; other site
487521010757	ATP binding site [chemical binding]; other site
487521010758	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
487521010759	YceI-like domain; Region: YceI; pfam04264
487521010760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
487521010761	active site
487521010762	phosphorylation site [posttranslational modification]
487521010763	intermolecular recognition site; other site
487521010764	dimerization interface [polypeptide binding]; other site
487521010765	NADH dehydrogenase subunit A; Validated; Region: PRK07928
487521010766	NADH dehydrogenase subunit B; Validated; Region: PRK06411
487521010767	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
487521010768	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
487521010769	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
487521010770	NADH dehydrogenase subunit D; Validated; Region: PRK06075
487521010771	NADH dehydrogenase subunit E; Validated; Region: PRK07539
487521010772	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
487521010773	putative dimer interface [polypeptide binding]; other site
487521010774	[2Fe-2S] cluster binding site [ion binding]; other site
487521010775	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
487521010776	SLBB domain; Region: SLBB; pfam10531
487521010777	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
487521010778	NADH dehydrogenase subunit G; Validated; Region: PRK07860
487521010779	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521010780	catalytic loop [active]
487521010781	iron binding site [ion binding]; other site
487521010782	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
487521010783	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521010784	molybdopterin cofactor binding site; other site
487521010785	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
487521010786	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
487521010787	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
487521010788	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
487521010789	4Fe-4S binding domain; Region: Fer4; pfam00037
487521010790	4Fe-4S binding domain; Region: Fer4; pfam00037
487521010791	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
487521010792	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
487521010793	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
487521010794	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
487521010795	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
487521010796	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
487521010797	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
487521010798	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
487521010799	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
487521010800	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
487521010801	Protein of unknown function DUF58; Region: DUF58; pfam01882
487521010802	MoxR-like ATPases [General function prediction only]; Region: COG0714
487521010803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521010804	Walker A motif; other site
487521010805	ATP binding site [chemical binding]; other site
487521010806	Walker B motif; other site
487521010807	arginine finger; other site
487521010808	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
487521010809	classical (c) SDRs; Region: SDR_c; cd05233
487521010810	NAD(P) binding site [chemical binding]; other site
487521010811	active site
487521010812	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010813	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521010814	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
487521010815	putative active site [active]
487521010816	putative substrate binding site [chemical binding]; other site
487521010817	ATP binding site [chemical binding]; other site
487521010818	Phosphotransferase enzyme family; Region: APH; pfam01636
487521010819	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
487521010820	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521010821	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521010822	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521010823	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521010824	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
487521010825	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521010826	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
487521010827	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521010828	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521010829	anti sigma factor interaction site; other site
487521010830	regulatory phosphorylation site [posttranslational modification]; other site
487521010831	hydroperoxidase II; Provisional; Region: katE; PRK11249
487521010832	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
487521010833	tetramer interface [polypeptide binding]; other site
487521010834	heme binding pocket [chemical binding]; other site
487521010835	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
487521010836	domain interactions; other site
487521010837	transcription termination factor Rho; Provisional; Region: PRK12678
487521010838	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521010839	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
487521010840	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
487521010841	putative catalytic site [active]
487521010842	putative metal binding site [ion binding]; other site
487521010843	putative phosphate binding site [ion binding]; other site
487521010844	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
487521010845	NADH(P)-binding; Region: NAD_binding_10; pfam13460
487521010846	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010847	NAD(P) binding site [chemical binding]; other site
487521010848	active site
487521010849	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651
487521010850	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
487521010851	Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006
487521010852	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
487521010853	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
487521010854	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
487521010855	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
487521010856	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
487521010857	active site
487521010858	DNA binding site [nucleotide binding]
487521010859	Int/Topo IB signature motif; other site
487521010860	thiamine pyrophosphate protein; Provisional; Region: PRK08273
487521010861	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
487521010862	PYR/PP interface [polypeptide binding]; other site
487521010863	dimer interface [polypeptide binding]; other site
487521010864	tetramer interface [polypeptide binding]; other site
487521010865	TPP binding site [chemical binding]; other site
487521010866	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521010867	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
487521010868	TPP-binding site [chemical binding]; other site
487521010869	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
487521010870	Fe-S cluster binding site [ion binding]; other site
487521010871	active site
487521010872	Hemerythrin-like domain; Region: Hr-like; cd12108
487521010873	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
487521010874	PknH-like extracellular domain; Region: PknH_C; pfam14032
487521010875	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521010876	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521010877	active site
487521010878	catalytic tetrad [active]
487521010879	classical (c) SDRs; Region: SDR_c; cd05233
487521010880	NAD(P) binding site [chemical binding]; other site
487521010881	active site
487521010882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
487521010883	PAS fold; Region: PAS_3; pfam08447
487521010884	putative active site [active]
487521010885	heme pocket [chemical binding]; other site
487521010886	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
487521010887	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
487521010888	metal binding site [ion binding]; metal-binding site
487521010889	active site
487521010890	I-site; other site
487521010891	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
487521010892	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
487521010893	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
487521010894	active site
487521010895	catalytic site [active]
487521010896	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
487521010897	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521010898	NAD binding site [chemical binding]; other site
487521010899	catalytic Zn binding site [ion binding]; other site
487521010900	structural Zn binding site [ion binding]; other site
487521010901	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
487521010902	GAF domain; Region: GAF; pfam01590
487521010903	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521010904	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
487521010905	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
487521010906	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
487521010907	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487521010908	DNA binding residues [nucleotide binding]
487521010909	putative dimer interface [polypeptide binding]; other site
487521010910	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
487521010911	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
487521010912	putative dimer interface [polypeptide binding]; other site
487521010913	PAS fold; Region: PAS_3; pfam08447
487521010914	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521010915	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
487521010916	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521010917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521010918	active site
487521010919	phosphorylation site [posttranslational modification]
487521010920	intermolecular recognition site; other site
487521010921	dimerization interface [polypeptide binding]; other site
487521010922	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521010923	DNA binding residues [nucleotide binding]
487521010924	dimerization interface [polypeptide binding]; other site
487521010925	Acyltransferase family; Region: Acyl_transf_3; pfam01757
487521010926	yiaA/B two helix domain; Region: YiaAB; cl01759
487521010927	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521010928	classical (c) SDRs; Region: SDR_c; cd05233
487521010929	NAD(P) binding site [chemical binding]; other site
487521010930	active site
487521010931	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521010932	Cytochrome P450; Region: p450; cl12078
487521010933	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521010934	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521010935	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
487521010936	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487521010937	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521010938	NAD(P) binding site [chemical binding]; other site
487521010939	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521010940	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
487521010941	DNA-binding interface [nucleotide binding]; DNA binding site
487521010942	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
487521010943	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
487521010944	FMN-binding pocket [chemical binding]; other site
487521010945	flavin binding motif; other site
487521010946	phosphate binding motif [ion binding]; other site
487521010947	beta-alpha-beta structure motif; other site
487521010948	NAD binding pocket [chemical binding]; other site
487521010949	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521010950	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
487521010951	catalytic loop [active]
487521010952	iron binding site [ion binding]; other site
487521010953	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521010954	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
487521010955	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
487521010956	acyl-CoA synthetase; Validated; Region: PRK05850
487521010957	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
487521010958	acyl-activating enzyme (AAE) consensus motif; other site
487521010959	active site
487521010960	thioester reductase domain; Region: Thioester-redct; TIGR01746
487521010961	Male sterility protein; Region: NAD_binding_4; pfam07993
487521010962	NAD(P) binding site [chemical binding]; other site
487521010963	active site
487521010964	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
487521010965	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
487521010966	short chain dehydrogenase; Provisional; Region: PRK06197
487521010967	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521010968	NAD(P) binding site [chemical binding]; other site
487521010969	active site
487521010970	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521010971	mce related protein; Region: MCE; pfam02470
487521010972	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521010973	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521010974	mce related protein; Region: MCE; pfam02470
487521010975	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521010976	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
487521010977	catalytic residues [active]
487521010978	dimer interface [polypeptide binding]; other site
487521010979	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
487521010980	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
487521010981	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521010982	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521010983	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
487521010984	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
487521010985	Flavoprotein; Region: Flavoprotein; pfam02441
487521010986	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
487521010987	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
487521010988	dimerization interface [polypeptide binding]; other site
487521010989	DPS ferroxidase diiron center [ion binding]; other site
487521010990	ion pore; other site
487521010991	Helix-turn-helix domain; Region: HTH_18; pfam12833
487521010992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521010993	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
487521010994	Nitroreductase family; Region: Nitroreductase; pfam00881
487521010995	FMN binding site [chemical binding]; other site
487521010996	dimer interface [polypeptide binding]; other site
487521010997	choline dehydrogenase; Validated; Region: PRK02106
487521010998	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
487521010999	AAA ATPase domain; Region: AAA_16; pfam13191
487521011000	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521011001	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521011002	DNA binding residues [nucleotide binding]
487521011003	dimerization interface [polypeptide binding]; other site
487521011004	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
487521011005	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
487521011006	conserved cys residue [active]
487521011007	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521011008	short chain dehydrogenase; Provisional; Region: PRK08219
487521011009	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
487521011010	NADP binding site [chemical binding]; other site
487521011011	active site
487521011012	steroid binding site; other site
487521011013	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
487521011014	FMN binding site [chemical binding]; other site
487521011015	dimer interface [polypeptide binding]; other site
487521011016	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
487521011017	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
487521011018	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
487521011019	conserved cys residue [active]
487521011020	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487521011021	hypothetical protein; Validated; Region: PRK00068
487521011022	Uncharacterized conserved protein [Function unknown]; Region: COG1615
487521011023	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
487521011024	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
487521011025	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
487521011026	Uncharacterized conserved protein [Function unknown]; Region: COG5282
487521011027	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
487521011028	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
487521011029	ABC1 family; Region: ABC1; pfam03109
487521011030	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
487521011031	active site
487521011032	ATP binding site [chemical binding]; other site
487521011033	Transcription factor WhiB; Region: Whib; pfam02467
487521011034	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
487521011035	Part of AAA domain; Region: AAA_19; pfam13245
487521011036	Family description; Region: UvrD_C_2; pfam13538
487521011037	HRDC domain; Region: HRDC; pfam00570
487521011038	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
487521011039	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
487521011040	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
487521011041	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
487521011042	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
487521011043	putative NADH binding site [chemical binding]; other site
487521011044	putative active site [active]
487521011045	nudix motif; other site
487521011046	putative metal binding site [ion binding]; other site
487521011047	Ion channel; Region: Ion_trans_2; pfam07885
487521011048	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
487521011049	TrkA-N domain; Region: TrkA_N; pfam02254
487521011050	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
487521011051	Part of AAA domain; Region: AAA_19; pfam13245
487521011052	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
487521011053	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
487521011054	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
487521011055	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
487521011056	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521011057	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521011058	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
487521011059	catalytic site [active]
487521011060	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
487521011061	active site
487521011062	DNA binding site [nucleotide binding]
487521011063	TIGR02569 family protein; Region: TIGR02569_actnb
487521011064	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
487521011065	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
487521011066	ATP binding site [chemical binding]; other site
487521011067	substrate interface [chemical binding]; other site
487521011068	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
487521011069	active site residue [active]
487521011070	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
487521011071	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521011072	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521011073	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
487521011074	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
487521011075	dinuclear metal binding motif [ion binding]; other site
487521011076	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
487521011077	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
487521011078	ATP binding site [chemical binding]; other site
487521011079	Mg++ binding site [ion binding]; other site
487521011080	motif III; other site
487521011081	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521011082	nucleotide binding region [chemical binding]; other site
487521011083	ATP-binding site [chemical binding]; other site
487521011084	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
487521011085	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
487521011086	P-loop; other site
487521011087	Magnesium ion binding site [ion binding]; other site
487521011088	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
487521011089	Magnesium ion binding site [ion binding]; other site
487521011090	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521011091	catalytic core [active]
487521011092	isochorismate synthase DhbC; Validated; Region: PRK06923
487521011093	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
487521011094	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487521011095	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
487521011096	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
487521011097	Transcription factor WhiB; Region: Whib; pfam02467
487521011098	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
487521011099	PAS domain S-box; Region: sensory_box; TIGR00229
487521011100	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
487521011101	Histidine kinase; Region: HisKA_2; pfam07568
487521011102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521011103	ATP binding site [chemical binding]; other site
487521011104	Mg2+ binding site [ion binding]; other site
487521011105	G-X-G motif; other site
487521011106	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
487521011107	carboxyltransferase (CT) interaction site; other site
487521011108	biotinylation site [posttranslational modification]; other site
487521011109	anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin
487521011110	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
487521011111	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521011112	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521011113	DNA binding residues [nucleotide binding]
487521011114	short chain dehydrogenase; Provisional; Region: PRK08278
487521011115	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
487521011116	NAD(P) binding site [chemical binding]; other site
487521011117	homodimer interface [polypeptide binding]; other site
487521011118	active site
487521011119	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
487521011120	putative deacylase active site [active]
487521011121	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521011122	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487521011123	NAD(P) binding site [chemical binding]; other site
487521011124	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521011125	active site
487521011126	metal binding site [ion binding]; metal-binding site
487521011127	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
487521011128	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487521011129	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
487521011130	short chain dehydrogenase; Provisional; Region: PRK07856
487521011131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521011132	NAD(P) binding site [chemical binding]; other site
487521011133	active site
487521011134	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521011135	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521011136	classical (c) SDRs; Region: SDR_c; cd05233
487521011137	NAD(P) binding site [chemical binding]; other site
487521011138	active site
487521011139	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521011140	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521011141	Uncharacterized conserved protein [Function unknown]; Region: COG2135
487521011142	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
487521011143	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
487521011144	hinge; other site
487521011145	active site
487521011146	Predicted GTPases [General function prediction only]; Region: COG1162
487521011147	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
487521011148	GTPase/Zn-binding domain interface [polypeptide binding]; other site
487521011149	GTP/Mg2+ binding site [chemical binding]; other site
487521011150	G4 box; other site
487521011151	G5 box; other site
487521011152	G1 box; other site
487521011153	Switch I region; other site
487521011154	G2 box; other site
487521011155	G3 box; other site
487521011156	Switch II region; other site
487521011157	Predicted transcriptional regulators [Transcription]; Region: COG1733
487521011158	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
487521011159	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
487521011160	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521011161	dimer interface [polypeptide binding]; other site
487521011162	active site
487521011163	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
487521011164	Predicted amidohydrolase [General function prediction only]; Region: COG0388
487521011165	putative active site [active]
487521011166	catalytic triad [active]
487521011167	putative dimer interface [polypeptide binding]; other site
487521011168	Domain of unknown function DUF302; Region: DUF302; pfam03625
487521011169	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521011170	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
487521011171	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
487521011172	putative di-iron ligands [ion binding]; other site
487521011173	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
487521011174	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
487521011175	FAD binding pocket [chemical binding]; other site
487521011176	FAD binding motif [chemical binding]; other site
487521011177	phosphate binding motif [ion binding]; other site
487521011178	beta-alpha-beta structure motif; other site
487521011179	NAD binding pocket [chemical binding]; other site
487521011180	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521011181	catalytic loop [active]
487521011182	iron binding site [ion binding]; other site
487521011183	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521011184	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521011185	NnrU protein; Region: NnrU; cl17713
487521011186	Phospholipid methyltransferase; Region: PEMT; cl17370
487521011187	HD domain; Region: HD_5; pfam13487
487521011188	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487521011189	Zn2+ binding site [ion binding]; other site
487521011190	Mg2+ binding site [ion binding]; other site
487521011191	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521011192	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521011193	DNA binding residues [nucleotide binding]
487521011194	dimerization interface [polypeptide binding]; other site
487521011195	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
487521011196	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
487521011197	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
487521011198	30S subunit binding site; other site
487521011199	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
487521011200	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521011201	active site
487521011202	lipoprotein LpqB; Provisional; Region: PRK13616
487521011203	Sporulation and spore germination; Region: Germane; pfam10646
487521011204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521011205	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487521011206	dimerization interface [polypeptide binding]; other site
487521011207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521011208	dimer interface [polypeptide binding]; other site
487521011209	phosphorylation site [posttranslational modification]
487521011210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521011211	ATP binding site [chemical binding]; other site
487521011212	Mg2+ binding site [ion binding]; other site
487521011213	G-X-G motif; other site
487521011214	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521011215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521011216	active site
487521011217	phosphorylation site [posttranslational modification]
487521011218	intermolecular recognition site; other site
487521011219	dimerization interface [polypeptide binding]; other site
487521011220	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521011221	DNA binding site [nucleotide binding]
487521011222	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
487521011223	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
487521011224	TMP-binding site; other site
487521011225	ATP-binding site [chemical binding]; other site
487521011226	Adenosylhomocysteinase; Provisional; Region: PTZ00075
487521011227	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
487521011228	homotetramer interface [polypeptide binding]; other site
487521011229	ligand binding site [chemical binding]; other site
487521011230	catalytic site [active]
487521011231	NAD binding site [chemical binding]; other site
487521011232	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521011233	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521011234	Rubredoxin [Energy production and conversion]; Region: COG1773
487521011235	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
487521011236	iron binding site [ion binding]; other site
487521011237	Rubredoxin [Energy production and conversion]; Region: COG1773
487521011238	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
487521011239	iron binding site [ion binding]; other site
487521011240	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
487521011241	Fatty acid desaturase; Region: FA_desaturase; pfam00487
487521011242	Di-iron ligands [ion binding]; other site
487521011243	amino acid transporter; Region: 2A0306; TIGR00909
487521011244	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
487521011245	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
487521011246	hypothetical protein; Provisional; Region: PRK07236
487521011247	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
487521011248	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
487521011249	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
487521011250	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
487521011251	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
487521011252	active site
487521011253	substrate binding site [chemical binding]; other site
487521011254	metal binding site [ion binding]; metal-binding site
487521011255	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
487521011256	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
487521011257	Transcription factor WhiB; Region: Whib; pfam02467
487521011258	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
487521011259	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
487521011260	phosphate binding site [ion binding]; other site
487521011261	dimer interface [polypeptide binding]; other site
487521011262	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
487521011263	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
487521011264	F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553
487521011265	FMN binding site [chemical binding]; other site
487521011266	dimer interface [polypeptide binding]; other site
487521011267	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
487521011268	Methyltransferase domain; Region: Methyltransf_26; pfam13659
487521011269	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
487521011270	nudix motif; other site
487521011271	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
487521011272	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
487521011273	active site
487521011274	Substrate binding site; other site
487521011275	Mg++ binding site; other site
487521011276	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
487521011277	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
487521011278	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
487521011279	Probable Catalytic site; other site
487521011280	metal-binding site
487521011281	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
487521011282	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
487521011283	NADP binding site [chemical binding]; other site
487521011284	active site
487521011285	putative substrate binding site [chemical binding]; other site
487521011286	Transcriptional regulator [Transcription]; Region: LytR; COG1316
487521011287	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
487521011288	TIGR03089 family protein; Region: TIGR03089
487521011289	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
487521011290	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
487521011291	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521011292	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
487521011293	active site
487521011294	motif I; other site
487521011295	motif II; other site
487521011296	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
487521011297	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521011298	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521011299	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521011300	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521011301	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521011302	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521011303	active site
487521011304	ATP binding site [chemical binding]; other site
487521011305	substrate binding site [chemical binding]; other site
487521011306	activation loop (A-loop); other site
487521011307	Uncharacterized conserved protein [Function unknown]; Region: COG3391
487521011308	NHL repeat; Region: NHL; pfam01436
487521011309	NHL repeat; Region: NHL; pfam01436
487521011310	NHL repeat; Region: NHL; pfam01436
487521011311	NHL repeat; Region: NHL; pfam01436
487521011312	NHL repeat; Region: NHL; pfam01436
487521011313	PBP superfamily domain; Region: PBP_like_2; cl17296
487521011314	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
487521011315	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
487521011316	Walker A/P-loop; other site
487521011317	ATP binding site [chemical binding]; other site
487521011318	Q-loop/lid; other site
487521011319	ABC transporter signature motif; other site
487521011320	Walker B; other site
487521011321	D-loop; other site
487521011322	H-loop/switch region; other site
487521011323	PBP superfamily domain; Region: PBP_like_2; cl17296
487521011324	PBP superfamily domain; Region: PBP_like_2; cl17296
487521011325	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
487521011326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521011327	dimer interface [polypeptide binding]; other site
487521011328	conserved gate region; other site
487521011329	putative PBP binding loops; other site
487521011330	ABC-ATPase subunit interface; other site
487521011331	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
487521011332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487521011333	dimer interface [polypeptide binding]; other site
487521011334	conserved gate region; other site
487521011335	ABC-ATPase subunit interface; other site
487521011336	Response regulator receiver domain; Region: Response_reg; pfam00072
487521011337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521011338	active site
487521011339	phosphorylation site [posttranslational modification]
487521011340	intermolecular recognition site; other site
487521011341	dimerization interface [polypeptide binding]; other site
487521011342	CHASE3 domain; Region: CHASE3; pfam05227
487521011343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521011344	dimer interface [polypeptide binding]; other site
487521011345	phosphorylation site [posttranslational modification]
487521011346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521011347	ATP binding site [chemical binding]; other site
487521011348	Mg2+ binding site [ion binding]; other site
487521011349	G-X-G motif; other site
487521011350	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
487521011351	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521011352	active site
487521011353	phosphorylation site [posttranslational modification]
487521011354	intermolecular recognition site; other site
487521011355	dimerization interface [polypeptide binding]; other site
487521011356	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
487521011357	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521011358	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
487521011359	FAD binding site [chemical binding]; other site
487521011360	homotetramer interface [polypeptide binding]; other site
487521011361	substrate binding pocket [chemical binding]; other site
487521011362	catalytic base [active]
487521011363	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
487521011364	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
487521011365	ATP-grasp domain; Region: ATP-grasp; pfam02222
487521011366	Predicted membrane protein [Function unknown]; Region: COG2246
487521011367	GtrA-like protein; Region: GtrA; pfam04138
487521011368	Bacterial PH domain; Region: DUF304; pfam03703
487521011369	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
487521011370	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
487521011371	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
487521011372	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
487521011373	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
487521011374	acyl-CoA synthetase; Provisional; Region: PRK13388
487521011375	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521011376	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521011377	active site
487521011378	CoA binding site [chemical binding]; other site
487521011379	AMP binding site [chemical binding]; other site
487521011380	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521011381	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
487521011382	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
487521011383	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
487521011384	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
487521011385	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
487521011386	active site
487521011387	dimer interface [polypeptide binding]; other site
487521011388	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
487521011389	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
487521011390	active site residue [active]
487521011391	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
487521011392	active site residue [active]
487521011393	Fe-S metabolism associated domain; Region: SufE; cl00951
487521011394	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
487521011395	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487521011396	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
487521011397	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
487521011398	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
487521011399	carboxyltransferase (CT) interaction site; other site
487521011400	biotinylation site [posttranslational modification]; other site
487521011401	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521011402	anti sigma factor interaction site; other site
487521011403	regulatory phosphorylation site [posttranslational modification]; other site
487521011404	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
487521011405	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521011406	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
487521011407	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521011408	DNA binding residues [nucleotide binding]
487521011409	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
487521011410	L-lysine aminotransferase; Provisional; Region: PRK08297
487521011411	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
487521011412	inhibitor-cofactor binding pocket; inhibition site
487521011413	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521011414	catalytic residue [active]
487521011415	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
487521011416	AsnC family; Region: AsnC_trans_reg; pfam01037
487521011417	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
487521011418	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
487521011419	aldehyde dehydrogenase family 7 member; Region: PLN02315
487521011420	NAD(P) binding site [chemical binding]; other site
487521011421	catalytic residues [active]
487521011422	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487521011423	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
487521011424	ATP binding site [chemical binding]; other site
487521011425	putative Mg++ binding site [ion binding]; other site
487521011426	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487521011427	nucleotide binding region [chemical binding]; other site
487521011428	ATP-binding site [chemical binding]; other site
487521011429	DEAD/H associated; Region: DEAD_assoc; pfam08494
487521011430	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
487521011431	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
487521011432	putative DNA binding site [nucleotide binding]; other site
487521011433	catalytic residue [active]
487521011434	putative H2TH interface [polypeptide binding]; other site
487521011435	putative catalytic residues [active]
487521011436	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
487521011437	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
487521011438	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
487521011439	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521011440	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
487521011441	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
487521011442	oligomer interface [polypeptide binding]; other site
487521011443	metal binding site [ion binding]; metal-binding site
487521011444	metal binding site [ion binding]; metal-binding site
487521011445	putative Cl binding site [ion binding]; other site
487521011446	aspartate ring; other site
487521011447	basic sphincter; other site
487521011448	hydrophobic gate; other site
487521011449	periplasmic entrance; other site
487521011450	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521011451	PPE family; Region: PPE; pfam00823
487521011452	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521011453	PPE family; Region: PPE; pfam00823
487521011454	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487521011455	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
487521011456	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
487521011457	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
487521011458	active site
487521011459	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
487521011460	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
487521011461	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521011462	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521011463	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487521011464	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
487521011465	putative active site pocket [active]
487521011466	dimerization interface [polypeptide binding]; other site
487521011467	putative catalytic residue [active]
487521011468	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521011469	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521011470	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
487521011471	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
487521011472	metal binding site [ion binding]; metal-binding site
487521011473	putative dimer interface [polypeptide binding]; other site
487521011474	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
487521011475	amidohydrolase; Region: amidohydrolases; TIGR01891
487521011476	metal binding site [ion binding]; metal-binding site
487521011477	Cutinase; Region: Cutinase; pfam01083
487521011478	purine nucleoside phosphorylase; Provisional; Region: PRK08202
487521011479	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
487521011480	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
487521011481	active site
487521011482	substrate binding site [chemical binding]; other site
487521011483	metal binding site [ion binding]; metal-binding site
487521011484	Phosphoesterase family; Region: Phosphoesterase; pfam04185
487521011485	hypothetical protein; Provisional; Region: PRK13685
487521011486	von Willebrand factor type A domain; Region: VWA_2; pfam13519
487521011487	metal ion-dependent adhesion site (MIDAS); other site
487521011488	hypothetical protein; Provisional; Region: PRK13685
487521011489	von Willebrand factor type A domain; Region: VWA_2; pfam13519
487521011490	metal ion-dependent adhesion site (MIDAS); other site
487521011491	Cupin domain; Region: Cupin_2; cl17218
487521011492	Cupin domain; Region: Cupin_2; pfam07883
487521011493	Transcriptional regulators [Transcription]; Region: GntR; COG1802
487521011494	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521011495	DNA-binding site [nucleotide binding]; DNA binding site
487521011496	FCD domain; Region: FCD; pfam07729
487521011497	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
487521011498	adenosine deaminase; Provisional; Region: PRK09358
487521011499	active site
487521011500	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
487521011501	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
487521011502	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
487521011503	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
487521011504	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
487521011505	active site
487521011506	catalytic motif [active]
487521011507	Zn binding site [ion binding]; other site
487521011508	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
487521011509	putative Iron-sulfur protein interface [polypeptide binding]; other site
487521011510	putative proximal heme binding site [chemical binding]; other site
487521011511	putative SdhD-like interface [polypeptide binding]; other site
487521011512	putative distal heme binding site [chemical binding]; other site
487521011513	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
487521011514	putative Iron-sulfur protein interface [polypeptide binding]; other site
487521011515	putative proximal heme binding site [chemical binding]; other site
487521011516	putative SdhC-like subunit interface [polypeptide binding]; other site
487521011517	putative distal heme binding site [chemical binding]; other site
487521011518	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
487521011519	L-aspartate oxidase; Provisional; Region: PRK06175
487521011520	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
487521011521	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
487521011522	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
487521011523	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521011524	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
487521011525	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
487521011526	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
487521011527	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521011528	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521011529	DNA binding residues [nucleotide binding]
487521011530	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521011531	hypothetical protein; Provisional; Region: PRK06541
487521011532	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
487521011533	inhibitor-cofactor binding pocket; inhibition site
487521011534	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521011535	catalytic residue [active]
487521011536	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
487521011537	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
487521011538	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
487521011539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521011540	putative substrate translocation pore; other site
487521011541	Amidohydrolase; Region: Amidohydro_4; pfam13147
487521011542	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521011543	active site
487521011544	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
487521011545	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
487521011546	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
487521011547	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
487521011548	active site
487521011549	HIGH motif; other site
487521011550	dimer interface [polypeptide binding]; other site
487521011551	KMSKS motif; other site
487521011552	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521011553	isocitrate dehydrogenase; Validated; Region: PRK08299
487521011554	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
487521011555	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
487521011556	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
487521011557	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
487521011558	homodimer interface [polypeptide binding]; other site
487521011559	substrate-cofactor binding pocket; other site
487521011560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521011561	catalytic residue [active]
487521011562	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
487521011563	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
487521011564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521011565	S-adenosylmethionine binding site [chemical binding]; other site
487521011566	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521011567	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
487521011568	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521011569	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521011570	active site
487521011571	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521011572	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
487521011573	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
487521011574	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
487521011575	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
487521011576	homodimer interface [polypeptide binding]; other site
487521011577	NADP binding site [chemical binding]; other site
487521011578	substrate binding site [chemical binding]; other site
487521011579	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
487521011580	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
487521011581	active site
487521011582	FMN binding site [chemical binding]; other site
487521011583	substrate binding site [chemical binding]; other site
487521011584	putative catalytic residue [active]
487521011585	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521011586	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521011587	phosphopeptide binding site; other site
487521011588	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521011589	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521011590	phosphopeptide binding site; other site
487521011591	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487521011592	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
487521011593	Walker A/P-loop; other site
487521011594	ATP binding site [chemical binding]; other site
487521011595	Q-loop/lid; other site
487521011596	ABC transporter signature motif; other site
487521011597	Walker B; other site
487521011598	D-loop; other site
487521011599	H-loop/switch region; other site
487521011600	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
487521011601	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
487521011602	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521011603	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521011604	phosphopeptide binding site; other site
487521011605	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
487521011606	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
487521011607	phosphopeptide binding site; other site
487521011608	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487521011609	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
487521011610	Walker A/P-loop; other site
487521011611	ATP binding site [chemical binding]; other site
487521011612	Q-loop/lid; other site
487521011613	ABC transporter signature motif; other site
487521011614	Walker B; other site
487521011615	D-loop; other site
487521011616	H-loop/switch region; other site
487521011617	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487521011618	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
487521011619	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
487521011620	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
487521011621	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
487521011622	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
487521011623	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
487521011624	G1 box; other site
487521011625	GTP/Mg2+ binding site [chemical binding]; other site
487521011626	G2 box; other site
487521011627	Switch I region; other site
487521011628	G3 box; other site
487521011629	Switch II region; other site
487521011630	G4 box; other site
487521011631	G5 box; other site
487521011632	Protein of unknown function (DUF742); Region: DUF742; pfam05331
487521011633	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
487521011634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521011635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521011636	ATP binding site [chemical binding]; other site
487521011637	Mg2+ binding site [ion binding]; other site
487521011638	G-X-G motif; other site
487521011639	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521011640	S-adenosylmethionine binding site [chemical binding]; other site
487521011641	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
487521011642	YCII-related domain; Region: YCII; cl00999
487521011643	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
487521011644	FMN binding site [chemical binding]; other site
487521011645	dimer interface [polypeptide binding]; other site
487521011646	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521011647	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521011648	Integrase core domain; Region: rve; pfam00665
487521011649	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
487521011650	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
487521011651	active site
487521011652	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
487521011653	generic binding surface II; other site
487521011654	generic binding surface I; other site
487521011655	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
487521011656	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
487521011657	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521011658	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
487521011659	dimer interaction site [polypeptide binding]; other site
487521011660	substrate-binding tunnel; other site
487521011661	active site
487521011662	catalytic site [active]
487521011663	substrate binding site [chemical binding]; other site
487521011664	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521011665	catalytic core [active]
487521011666	short chain dehydrogenase; Provisional; Region: PRK07201
487521011667	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
487521011668	putative NAD(P) binding site [chemical binding]; other site
487521011669	active site
487521011670	putative substrate binding site [chemical binding]; other site
487521011671	classical (c) SDRs; Region: SDR_c; cd05233
487521011672	NAD(P) binding site [chemical binding]; other site
487521011673	active site
487521011674	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521011675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521011676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521011677	S-adenosylmethionine binding site [chemical binding]; other site
487521011678	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
487521011679	active site
487521011680	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
487521011681	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
487521011682	dimer interface [polypeptide binding]; other site
487521011683	active site
487521011684	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
487521011685	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
487521011686	putative active site [active]
487521011687	putative substrate binding site [chemical binding]; other site
487521011688	putative FMN binding site [chemical binding]; other site
487521011689	putative catalytic residues [active]
487521011690	DNA Polymerase Y-family; Region: PolY_like; cd03468
487521011691	DNA binding site [nucleotide binding]
487521011692	GMP synthase; Reviewed; Region: guaA; PRK00074
487521011693	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
487521011694	AMP/PPi binding site [chemical binding]; other site
487521011695	candidate oxyanion hole; other site
487521011696	catalytic triad [active]
487521011697	potential glutamine specificity residues [chemical binding]; other site
487521011698	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
487521011699	ATP Binding subdomain [chemical binding]; other site
487521011700	Ligand Binding sites [chemical binding]; other site
487521011701	Dimerization subdomain; other site
487521011702	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521011703	PPE family; Region: PPE; pfam00823
487521011704	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521011705	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
487521011706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521011707	motif II; other site
487521011708	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
487521011709	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
487521011710	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
487521011711	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
487521011712	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521011713	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521011714	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
487521011715	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
487521011716	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
487521011717	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
487521011718	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
487521011719	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
487521011720	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
487521011721	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487521011722	phosphate binding site [ion binding]; other site
487521011723	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
487521011724	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487521011725	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
487521011726	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
487521011727	active site
487521011728	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
487521011729	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521011730	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
487521011731	DNA binding residues [nucleotide binding]
487521011732	Transcription factor WhiB; Region: Whib; pfam02467
487521011733	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
487521011734	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
487521011735	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
487521011736	[2Fe-2S] cluster binding site [ion binding]; other site
487521011737	Hemerythrin-like domain; Region: Hr-like; cd12108
487521011738	Fe binding site [ion binding]; other site
487521011739	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
487521011740	E-class dimer interface [polypeptide binding]; other site
487521011741	P-class dimer interface [polypeptide binding]; other site
487521011742	active site
487521011743	Cu2+ binding site [ion binding]; other site
487521011744	Zn2+ binding site [ion binding]; other site
487521011745	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
487521011746	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
487521011747	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
487521011748	ring oligomerisation interface [polypeptide binding]; other site
487521011749	ATP/Mg binding site [chemical binding]; other site
487521011750	stacking interactions; other site
487521011751	hinge regions; other site
487521011752	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
487521011753	oligomerisation interface [polypeptide binding]; other site
487521011754	mobile loop; other site
487521011755	roof hairpin; other site
487521011756	UGMP family protein; Validated; Region: PRK09604
487521011757	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
487521011758	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
487521011759	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521011760	Coenzyme A binding pocket [chemical binding]; other site
487521011761	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
487521011762	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
487521011763	Glycoprotease family; Region: Peptidase_M22; pfam00814
487521011764	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
487521011765	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521011766	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521011767	alanine racemase; Reviewed; Region: alr; PRK00053
487521011768	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
487521011769	active site
487521011770	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487521011771	dimer interface [polypeptide binding]; other site
487521011772	substrate binding site [chemical binding]; other site
487521011773	catalytic residues [active]
487521011774	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
487521011775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521011776	catalytic residue [active]
487521011777	Uncharacterized conserved protein [Function unknown]; Region: COG0062
487521011778	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
487521011779	putative substrate binding site [chemical binding]; other site
487521011780	putative ATP binding site [chemical binding]; other site
487521011781	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
487521011782	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
487521011783	glutaminase active site [active]
487521011784	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
487521011785	dimer interface [polypeptide binding]; other site
487521011786	active site
487521011787	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
487521011788	dimer interface [polypeptide binding]; other site
487521011789	active site
487521011790	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521011791	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
487521011792	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521011793	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
487521011794	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
487521011795	active site
487521011796	substrate binding site [chemical binding]; other site
487521011797	metal binding site [ion binding]; metal-binding site
487521011798	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
487521011799	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
487521011800	23S rRNA interface [nucleotide binding]; other site
487521011801	L3 interface [polypeptide binding]; other site
487521011802	Proteins of 100 residues with WXG; Region: WXG100; cl02005
487521011803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
487521011804	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
487521011805	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
487521011806	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521011807	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
487521011808	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521011809	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521011810	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
487521011811	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
487521011812	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
487521011813	active site
487521011814	catalytic residues [active]
487521011815	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
487521011816	Cutinase; Region: Cutinase; pfam01083
487521011817	Cutinase; Region: Cutinase; pfam01083
487521011818	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
487521011819	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
487521011820	active site
487521011821	dimerization interface 3.5A [polypeptide binding]; other site
487521011822	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
487521011823	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
487521011824	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
487521011825	alphaNTD homodimer interface [polypeptide binding]; other site
487521011826	alphaNTD - beta interaction site [polypeptide binding]; other site
487521011827	alphaNTD - beta' interaction site [polypeptide binding]; other site
487521011828	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
487521011829	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
487521011830	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
487521011831	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487521011832	RNA binding surface [nucleotide binding]; other site
487521011833	30S ribosomal protein S11; Validated; Region: PRK05309
487521011834	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
487521011835	30S ribosomal protein S13; Region: bact_S13; TIGR03631
487521011836	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
487521011837	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
487521011838	rRNA binding site [nucleotide binding]; other site
487521011839	predicted 30S ribosome binding site; other site
487521011840	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
487521011841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521011842	active site
487521011843	phosphorylation site [posttranslational modification]
487521011844	intermolecular recognition site; other site
487521011845	dimerization interface [polypeptide binding]; other site
487521011846	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
487521011847	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521011848	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521011849	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
487521011850	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
487521011851	ligand binding site [chemical binding]; other site
487521011852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487521011853	flexible hinge region; other site
487521011854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521011855	ATP binding site [chemical binding]; other site
487521011856	Mg2+ binding site [ion binding]; other site
487521011857	G-X-G motif; other site
487521011858	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
487521011859	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
487521011860	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521011861	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
487521011862	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
487521011863	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
487521011864	NAD binding site [chemical binding]; other site
487521011865	substrate binding site [chemical binding]; other site
487521011866	homodimer interface [polypeptide binding]; other site
487521011867	active site
487521011868	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
487521011869	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521011870	Acyltransferase family; Region: Acyl_transf_3; pfam01757
487521011871	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521011872	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
487521011873	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
487521011874	active site
487521011875	metal binding site [ion binding]; metal-binding site
487521011876	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
487521011877	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
487521011878	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
487521011879	iron-sulfur cluster [ion binding]; other site
487521011880	[2Fe-2S] cluster binding site [ion binding]; other site
487521011881	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
487521011882	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521011883	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521011884	DNA binding residues [nucleotide binding]
487521011885	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521011886	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
487521011887	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
487521011888	tetrameric interface [polypeptide binding]; other site
487521011889	NAD binding site [chemical binding]; other site
487521011890	catalytic residues [active]
487521011891	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521011892	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521011893	active site
487521011894	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487521011895	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
487521011896	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521011897	MarR family; Region: MarR; pfam01047
487521011898	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
487521011899	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521011900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521011901	homodimer interface [polypeptide binding]; other site
487521011902	catalytic residue [active]
487521011903	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
487521011904	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
487521011905	active site
487521011906	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776
487521011907	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
487521011908	PYR/PP interface [polypeptide binding]; other site
487521011909	dimer interface [polypeptide binding]; other site
487521011910	TPP binding site [chemical binding]; other site
487521011911	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
487521011912	TPP-binding site [chemical binding]; other site
487521011913	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487521011914	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487521011915	Walker A/P-loop; other site
487521011916	ATP binding site [chemical binding]; other site
487521011917	Q-loop/lid; other site
487521011918	ABC transporter signature motif; other site
487521011919	Walker B; other site
487521011920	D-loop; other site
487521011921	H-loop/switch region; other site
487521011922	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
487521011923	FtsX-like permease family; Region: FtsX; pfam02687
487521011924	Methyltransferase domain; Region: Methyltransf_11; pfam08241
487521011925	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
487521011926	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
487521011927	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521011928	Putative zinc-finger; Region: zf-HC2; pfam13490
487521011929	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
487521011930	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521011931	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521011932	DNA binding residues [nucleotide binding]
487521011933	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
487521011934	active site
487521011935	adenylate kinase; Reviewed; Region: adk; PRK00279
487521011936	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
487521011937	AMP-binding site [chemical binding]; other site
487521011938	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
487521011939	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
487521011940	SecY translocase; Region: SecY; pfam00344
487521011941	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521011942	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521011943	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487521011944	Coenzyme A binding pocket [chemical binding]; other site
487521011945	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521011946	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
487521011947	nucleotide binding site [chemical binding]; other site
487521011948	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
487521011949	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
487521011950	NAD binding site [chemical binding]; other site
487521011951	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
487521011952	intersubunit interface [polypeptide binding]; other site
487521011953	active site
487521011954	Zn2+ binding site [ion binding]; other site
487521011955	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521011956	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487521011957	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521011958	NAD(P) binding site [chemical binding]; other site
487521011959	classical (c) SDRs; Region: SDR_c; cd05233
487521011960	NAD(P) binding site [chemical binding]; other site
487521011961	active site
487521011962	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521011963	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521011964	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521011965	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521011966	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521011967	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521011968	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
487521011969	tandem repeat interface [polypeptide binding]; other site
487521011970	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
487521011971	oligomer interface [polypeptide binding]; other site
487521011972	active site residues [active]
487521011973	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
487521011974	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
487521011975	tandem repeat interface [polypeptide binding]; other site
487521011976	oligomer interface [polypeptide binding]; other site
487521011977	active site residues [active]
487521011978	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521011979	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521011980	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
487521011981	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
487521011982	23S rRNA binding site [nucleotide binding]; other site
487521011983	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
487521011984	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
487521011985	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
487521011986	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
487521011987	5S rRNA interface [nucleotide binding]; other site
487521011988	L27 interface [polypeptide binding]; other site
487521011989	23S rRNA interface [nucleotide binding]; other site
487521011990	L5 interface [polypeptide binding]; other site
487521011991	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
487521011992	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
487521011993	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
487521011994	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
487521011995	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
487521011996	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
487521011997	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
487521011998	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
487521011999	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
487521012000	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
487521012001	RNA binding site [nucleotide binding]; other site
487521012002	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
487521012003	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521012004	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521012005	active site
487521012006	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
487521012007	Uncharacterized conserved protein [Function unknown]; Region: COG1262
487521012008	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
487521012009	Sulfatase; Region: Sulfatase; pfam00884
487521012010	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
487521012011	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
487521012012	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
487521012013	putative translocon interaction site; other site
487521012014	signal recognition particle (SRP54) interaction site; other site
487521012015	L23 interface [polypeptide binding]; other site
487521012016	trigger factor interaction site; other site
487521012017	23S rRNA interface [nucleotide binding]; other site
487521012018	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
487521012019	23S rRNA interface [nucleotide binding]; other site
487521012020	5S rRNA interface [nucleotide binding]; other site
487521012021	putative antibiotic binding site [chemical binding]; other site
487521012022	L25 interface [polypeptide binding]; other site
487521012023	L27 interface [polypeptide binding]; other site
487521012024	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
487521012025	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
487521012026	G-X-X-G motif; other site
487521012027	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
487521012028	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
487521012029	putative translocon binding site; other site
487521012030	protein-rRNA interface [nucleotide binding]; other site
487521012031	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
487521012032	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
487521012033	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
487521012034	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
487521012035	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
487521012036	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
487521012037	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
487521012038	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
487521012039	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521012040	Cytochrome P450; Region: p450; cl12078
487521012041	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
487521012042	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
487521012043	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
487521012044	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487521012045	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
487521012046	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
487521012047	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487521012048	phosphate binding site [ion binding]; other site
487521012049	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
487521012050	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487521012051	FeS/SAM binding site; other site
487521012052	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
487521012053	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
487521012054	mycofactocin precursor; Region: mycofactocin; TIGR03969
487521012055	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521012056	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012057	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837
487521012058	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521012059	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521012060	active site
487521012061	catalytic tetrad [active]
487521012062	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
487521012063	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
487521012064	active site
487521012065	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
487521012066	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521012067	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521012068	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521012069	classical (c) SDRs; Region: SDR_c; cd05233
487521012070	NAD(P) binding site [chemical binding]; other site
487521012071	active site
487521012072	Short C-terminal domain; Region: SHOCT; pfam09851
487521012073	PE family; Region: PE; pfam00934
487521012074	elongation factor Tu; Reviewed; Region: PRK00049
487521012075	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
487521012076	G1 box; other site
487521012077	GEF interaction site [polypeptide binding]; other site
487521012078	GTP/Mg2+ binding site [chemical binding]; other site
487521012079	Switch I region; other site
487521012080	G2 box; other site
487521012081	G3 box; other site
487521012082	Switch II region; other site
487521012083	G4 box; other site
487521012084	G5 box; other site
487521012085	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
487521012086	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
487521012087	Antibiotic Binding Site [chemical binding]; other site
487521012088	elongation factor G; Reviewed; Region: PRK00007
487521012089	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
487521012090	G1 box; other site
487521012091	putative GEF interaction site [polypeptide binding]; other site
487521012092	GTP/Mg2+ binding site [chemical binding]; other site
487521012093	Switch I region; other site
487521012094	G2 box; other site
487521012095	G3 box; other site
487521012096	Switch II region; other site
487521012097	G4 box; other site
487521012098	G5 box; other site
487521012099	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
487521012100	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
487521012101	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
487521012102	30S ribosomal protein S7; Validated; Region: PRK05302
487521012103	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
487521012104	S17 interaction site [polypeptide binding]; other site
487521012105	S8 interaction site; other site
487521012106	16S rRNA interaction site [nucleotide binding]; other site
487521012107	streptomycin interaction site [chemical binding]; other site
487521012108	23S rRNA interaction site [nucleotide binding]; other site
487521012109	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
487521012110	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521012111	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012112	WHG domain; Region: WHG; pfam13305
487521012113	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
487521012114	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
487521012115	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521012116	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521012117	substrate binding site [chemical binding]; other site
487521012118	oxyanion hole (OAH) forming residues; other site
487521012119	trimer interface [polypeptide binding]; other site
487521012120	PaaX-like protein; Region: PaaX; pfam07848
487521012121	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
487521012122	enoyl-CoA hydratase; Provisional; Region: PRK12478
487521012123	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521012124	substrate binding site [chemical binding]; other site
487521012125	oxyanion hole (OAH) forming residues; other site
487521012126	trimer interface [polypeptide binding]; other site
487521012127	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
487521012128	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521012129	active site
487521012130	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
487521012131	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521012132	endonuclease IV; Provisional; Region: PRK01060
487521012133	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
487521012134	AP (apurinic/apyrimidinic) site pocket; other site
487521012135	DNA interaction; other site
487521012136	Metal-binding active site; metal-binding site
487521012137	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
487521012138	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
487521012139	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
487521012140	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
487521012141	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
487521012142	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
487521012143	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
487521012144	G-loop; other site
487521012145	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
487521012146	DNA binding site [nucleotide binding]
487521012147	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
487521012148	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
487521012149	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
487521012150	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
487521012151	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
487521012152	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
487521012153	RPB10 interaction site [polypeptide binding]; other site
487521012154	RPB1 interaction site [polypeptide binding]; other site
487521012155	RPB11 interaction site [polypeptide binding]; other site
487521012156	RPB3 interaction site [polypeptide binding]; other site
487521012157	RPB12 interaction site [polypeptide binding]; other site
487521012158	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
487521012159	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
487521012160	Walker A/P-loop; other site
487521012161	ATP binding site [chemical binding]; other site
487521012162	Q-loop/lid; other site
487521012163	ABC transporter signature motif; other site
487521012164	Walker B; other site
487521012165	D-loop; other site
487521012166	H-loop/switch region; other site
487521012167	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
487521012168	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
487521012169	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521012170	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012171	WHG domain; Region: WHG; pfam13305
487521012172	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
487521012173	core dimer interface [polypeptide binding]; other site
487521012174	peripheral dimer interface [polypeptide binding]; other site
487521012175	L10 interface [polypeptide binding]; other site
487521012176	L11 interface [polypeptide binding]; other site
487521012177	putative EF-Tu interaction site [polypeptide binding]; other site
487521012178	putative EF-G interaction site [polypeptide binding]; other site
487521012179	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
487521012180	23S rRNA interface [nucleotide binding]; other site
487521012181	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
487521012182	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
487521012183	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487521012184	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521012185	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
487521012186	active site
487521012187	catalytic site [active]
487521012188	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
487521012189	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
487521012190	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
487521012191	DinB superfamily; Region: DinB_2; pfam12867
487521012192	Protein of unknown function (DUF664); Region: DUF664; pfam04978
487521012193	DinB superfamily; Region: DinB_2; pfam12867
487521012194	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
487521012195	ABC1 family; Region: ABC1; pfam03109
487521012196	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
487521012197	active site
487521012198	ATP binding site [chemical binding]; other site
487521012199	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521012200	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
487521012201	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521012202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012203	S-adenosylmethionine binding site [chemical binding]; other site
487521012204	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521012205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012206	S-adenosylmethionine binding site [chemical binding]; other site
487521012207	YCII-related domain; Region: YCII; cl00999
487521012208	YCII-related domain; Region: YCII; cl00999
487521012209	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
487521012210	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521012211	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
487521012212	DNA binding residues [nucleotide binding]
487521012213	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
487521012214	mRNA/rRNA interface [nucleotide binding]; other site
487521012215	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
487521012216	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
487521012217	23S rRNA interface [nucleotide binding]; other site
487521012218	L7/L12 interface [polypeptide binding]; other site
487521012219	putative thiostrepton binding site; other site
487521012220	L25 interface [polypeptide binding]; other site
487521012221	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
487521012222	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
487521012223	putative homodimer interface [polypeptide binding]; other site
487521012224	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
487521012225	heterodimer interface [polypeptide binding]; other site
487521012226	homodimer interface [polypeptide binding]; other site
487521012227	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
487521012228	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
487521012229	active site
487521012230	catalytic site [active]
487521012231	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
487521012232	active site
487521012233	catalytic site [active]
487521012234	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
487521012235	active site
487521012236	catalytic site [active]
487521012237	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
487521012238	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
487521012239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
487521012240	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521012241	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521012242	substrate binding site [chemical binding]; other site
487521012243	oxyanion hole (OAH) forming residues; other site
487521012244	trimer interface [polypeptide binding]; other site
487521012245	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
487521012246	[4Fe-4S] binding site [ion binding]; other site
487521012247	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
487521012248	molybdopterin cofactor binding site; other site
487521012249	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
487521012250	molybdopterin cofactor binding site; other site
487521012251	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
487521012252	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
487521012253	active site
487521012254	nucleophile elbow; other site
487521012255	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
487521012256	cyanate hydratase; Validated; Region: PRK02866
487521012257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
487521012258	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
487521012259	oligomer interface [polypeptide binding]; other site
487521012260	active site
487521012261	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012262	S-adenosylmethionine binding site [chemical binding]; other site
487521012263	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
487521012264	putative FMN binding site [chemical binding]; other site
487521012265	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521012266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012267	S-adenosylmethionine binding site [chemical binding]; other site
487521012268	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
487521012269	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
487521012270	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
487521012271	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
487521012272	Part of AAA domain; Region: AAA_19; pfam13245
487521012273	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
487521012274	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
487521012275	AAA domain; Region: AAA_30; pfam13604
487521012276	Family description; Region: UvrD_C_2; pfam13538
487521012277	Uncharacterized conserved protein [Function unknown]; Region: COG0398
487521012278	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
487521012279	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521012280	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521012281	active site
487521012282	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521012283	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521012284	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
487521012285	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
487521012286	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
487521012287	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
487521012288	PAS fold; Region: PAS_3; pfam08447
487521012289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
487521012290	putative active site [active]
487521012291	heme pocket [chemical binding]; other site
487521012292	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521012293	galactokinase; Provisional; Region: PRK00555
487521012294	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
487521012295	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
487521012296	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
487521012297	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
487521012298	dimer interface [polypeptide binding]; other site
487521012299	active site
487521012300	Predicted membrane protein [Function unknown]; Region: COG1289
487521012301	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
487521012302	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521012303	Cytochrome P450; Region: p450; cl12078
487521012304	hypothetical protein; Provisional; Region: PRK07588
487521012305	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521012306	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521012307	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521012308	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
487521012309	NYN domain; Region: NYN; pfam01936
487521012310	putative metal binding site [ion binding]; other site
487521012311	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879
487521012312	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521012313	Cytochrome P450; Region: p450; cl12078
487521012314	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
487521012315	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
487521012316	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
487521012317	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521012318	molybdopterin cofactor binding site; other site
487521012319	Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568
487521012320	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
487521012321	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
487521012322	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521012323	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521012324	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
487521012325	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
487521012326	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
487521012327	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
487521012328	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
487521012329	Sulfate transporter family; Region: Sulfate_transp; pfam00916
487521012330	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487521012331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521012332	salt bridge; other site
487521012333	non-specific DNA binding site [nucleotide binding]; other site
487521012334	sequence-specific DNA binding site [nucleotide binding]; other site
487521012335	heat shock protein HtpX; Provisional; Region: PRK03072
487521012336	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
487521012337	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
487521012338	substrate binding pocket [chemical binding]; other site
487521012339	chain length determination region; other site
487521012340	substrate-Mg2+ binding site; other site
487521012341	catalytic residues [active]
487521012342	aspartate-rich region 1; other site
487521012343	active site lid residues [active]
487521012344	aspartate-rich region 2; other site
487521012345	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
487521012346	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487521012347	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521012348	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
487521012349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012350	S-adenosylmethionine binding site [chemical binding]; other site
487521012351	short chain dehydrogenase; Provisional; Region: PRK08263
487521012352	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
487521012353	NADP binding site [chemical binding]; other site
487521012354	active site
487521012355	steroid binding site; other site
487521012356	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521012357	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
487521012358	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
487521012359	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
487521012360	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
487521012361	dimer interface [polypeptide binding]; other site
487521012362	tetramer interface [polypeptide binding]; other site
487521012363	PYR/PP interface [polypeptide binding]; other site
487521012364	TPP binding site [chemical binding]; other site
487521012365	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
487521012366	TPP-binding site; other site
487521012367	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
487521012368	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521012369	TAP-like protein; Region: Abhydrolase_4; pfam08386
487521012370	O-succinylbenzoate synthase; Provisional; Region: PRK02901
487521012371	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
487521012372	active site
487521012373	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
487521012374	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
487521012375	active site
487521012376	acyl-CoA synthetase; Validated; Region: PRK06188
487521012377	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521012378	putative active site [active]
487521012379	putative CoA binding site [chemical binding]; other site
487521012380	putative AMP binding site [chemical binding]; other site
487521012381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521012382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012383	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487521012384	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487521012385	active site
487521012386	catalytic tetrad [active]
487521012387	Domain of unknown function (DUF385); Region: DUF385; cl04387
487521012388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521012389	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
487521012390	substrate binding site [chemical binding]; other site
487521012391	oxyanion hole (OAH) forming residues; other site
487521012392	trimer interface [polypeptide binding]; other site
487521012393	short chain dehydrogenase; Provisional; Region: PRK05866
487521012394	classical (c) SDRs; Region: SDR_c; cd05233
487521012395	NAD(P) binding site [chemical binding]; other site
487521012396	active site
487521012397	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521012398	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521012399	active site
487521012400	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
487521012401	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
487521012402	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
487521012403	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521012404	acyl-activating enzyme (AAE) consensus motif; other site
487521012405	AMP binding site [chemical binding]; other site
487521012406	active site
487521012407	CoA binding site [chemical binding]; other site
487521012408	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521012409	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521012410	Integrase core domain; Region: rve; pfam00665
487521012411	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
487521012412	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
487521012413	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
487521012414	Ligand binding site; other site
487521012415	Putative Catalytic site; other site
487521012416	DXD motif; other site
487521012417	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521012418	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521012419	NAD(P) binding site [chemical binding]; other site
487521012420	active site
487521012421	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
487521012422	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
487521012423	UbiA prenyltransferase family; Region: UbiA; pfam01040
487521012424	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
487521012425	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
487521012426	dimer interface [polypeptide binding]; other site
487521012427	active site
487521012428	CoA binding pocket [chemical binding]; other site
487521012429	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
487521012430	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
487521012431	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
487521012432	P-loop; other site
487521012433	Magnesium ion binding site [ion binding]; other site
487521012434	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
487521012435	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
487521012436	ResB-like family; Region: ResB; pfam05140
487521012437	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
487521012438	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
487521012439	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
487521012440	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487521012441	catalytic residues [active]
487521012442	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521012443	catalytic core [active]
487521012444	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
487521012445	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
487521012446	inhibitor-cofactor binding pocket; inhibition site
487521012447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521012448	catalytic residue [active]
487521012449	Domain of unknown function (DUF385); Region: DUF385; cl04387
487521012450	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
487521012451	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
487521012452	metal binding site [ion binding]; metal-binding site
487521012453	substrate binding pocket [chemical binding]; other site
487521012454	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
487521012455	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
487521012456	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
487521012457	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
487521012458	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521012459	acyl-activating enzyme (AAE) consensus motif; other site
487521012460	AMP binding site [chemical binding]; other site
487521012461	active site
487521012462	CoA binding site [chemical binding]; other site
487521012463	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
487521012464	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
487521012465	putative NAD(P) binding site [chemical binding]; other site
487521012466	active site
487521012467	putative substrate binding site [chemical binding]; other site
487521012468	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
487521012469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521012470	metabolite-proton symporter; Region: 2A0106; TIGR00883
487521012471	putative substrate translocation pore; other site
487521012472	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
487521012473	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
487521012474	active site
487521012475	dimer interface [polypeptide binding]; other site
487521012476	non-prolyl cis peptide bond; other site
487521012477	insertion regions; other site
487521012478	Putative esterase; Region: Esterase; pfam00756
487521012479	S-formylglutathione hydrolase; Region: PLN02442
487521012480	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521012481	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
487521012482	active site
487521012483	catalytic triad [active]
487521012484	oxyanion hole [active]
487521012485	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521012486	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521012487	anti sigma factor interaction site; other site
487521012488	regulatory phosphorylation site [posttranslational modification]; other site
487521012489	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
487521012490	dimer interface [polypeptide binding]; other site
487521012491	active site
487521012492	Schiff base residues; other site
487521012493	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
487521012494	active site
487521012495	homodimer interface [polypeptide binding]; other site
487521012496	SAM binding site [chemical binding]; other site
487521012497	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
487521012498	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
487521012499	active site
487521012500	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
487521012501	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
487521012502	domain interfaces; other site
487521012503	active site
487521012504	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
487521012505	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
487521012506	tRNA; other site
487521012507	putative tRNA binding site [nucleotide binding]; other site
487521012508	putative NADP binding site [chemical binding]; other site
487521012509	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
487521012510	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
487521012511	Proteins of 100 residues with WXG; Region: WXG100; cl02005
487521012512	Proteins of 100 residues with WXG; Region: WXG100; cl02005
487521012513	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
487521012514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521012515	motif II; other site
487521012516	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
487521012517	active site
487521012518	catalytic site [active]
487521012519	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521012520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487521012521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012522	S-adenosylmethionine binding site [chemical binding]; other site
487521012523	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487521012524	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
487521012525	putative acyl-acceptor binding pocket; other site
487521012526	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
487521012527	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
487521012528	putative NAD(P) binding site [chemical binding]; other site
487521012529	active site
487521012530	putative substrate binding site [chemical binding]; other site
487521012531	DNA binding domain, excisionase family; Region: excise; TIGR01764
487521012532	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
487521012533	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
487521012534	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
487521012535	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487521012536	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521012537	active site 2 [active]
487521012538	active site 1 [active]
487521012539	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
487521012540	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487521012541	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
487521012542	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
487521012543	DNA interaction; other site
487521012544	dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144
487521012545	exopolyphosphatase; Region: exo_poly_only; TIGR03706
487521012546	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
487521012547	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487521012548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521012549	active site
487521012550	phosphorylation site [posttranslational modification]
487521012551	intermolecular recognition site; other site
487521012552	dimerization interface [polypeptide binding]; other site
487521012553	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487521012554	DNA binding site [nucleotide binding]
487521012555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487521012556	dimer interface [polypeptide binding]; other site
487521012557	phosphorylation site [posttranslational modification]
487521012558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487521012559	ATP binding site [chemical binding]; other site
487521012560	Mg2+ binding site [ion binding]; other site
487521012561	G-X-G motif; other site
487521012562	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521012563	catalytic core [active]
487521012564	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487521012565	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
487521012566	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
487521012567	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
487521012568	putative ADP-binding pocket [chemical binding]; other site
487521012569	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487521012570	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521012571	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
487521012572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521012573	NAD(P) binding site [chemical binding]; other site
487521012574	active site
487521012575	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
487521012576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
487521012577	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
487521012578	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
487521012579	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
487521012580	FAD binding domain; Region: FAD_binding_4; pfam01565
487521012581	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
487521012582	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
487521012583	Predicted amidohydrolase [General function prediction only]; Region: COG0388
487521012584	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
487521012585	putative active site [active]
487521012586	catalytic triad [active]
487521012587	putative dimer interface [polypeptide binding]; other site
487521012588	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
487521012589	deoxyribose-phosphate aldolase; Provisional; Region: PRK00507
487521012590	catalytic residue [active]
487521012591	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
487521012592	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
487521012593	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521012594	non-specific DNA binding site [nucleotide binding]; other site
487521012595	salt bridge; other site
487521012596	sequence-specific DNA binding site [nucleotide binding]; other site
487521012597	Predicted membrane protein [Function unknown]; Region: COG2733
487521012598	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521012599	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012600	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521012601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012602	S-adenosylmethionine binding site [chemical binding]; other site
487521012603	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
487521012604	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012605	S-adenosylmethionine binding site [chemical binding]; other site
487521012606	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
487521012607	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
487521012608	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
487521012609	isocitrate lyase; Provisional; Region: PRK15063
487521012610	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
487521012611	tetramer interface [polypeptide binding]; other site
487521012612	active site
487521012613	Mg2+/Mn2+ binding site [ion binding]; other site
487521012614	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
487521012615	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521012616	active site 2 [active]
487521012617	active site 1 [active]
487521012618	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521012619	active site 2 [active]
487521012620	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487521012621	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487521012622	non-specific DNA binding site [nucleotide binding]; other site
487521012623	salt bridge; other site
487521012624	sequence-specific DNA binding site [nucleotide binding]; other site
487521012625	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
487521012626	Domain of unknown function (DUF955); Region: DUF955; pfam06114
487521012627	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
487521012628	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487521012629	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521012630	Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; Region: Calpain_III; cl00165
487521012631	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
487521012632	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
487521012633	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521012634	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487521012635	Protein of unknown function (DUF779); Region: DUF779; cl01432
487521012636	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
487521012637	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521012638	NAD(P) binding site [chemical binding]; other site
487521012639	catalytic residues [active]
487521012640	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
487521012641	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521012642	enoyl-CoA hydratase; Provisional; Region: PRK12478
487521012643	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521012644	substrate binding site [chemical binding]; other site
487521012645	oxyanion hole (OAH) forming residues; other site
487521012646	trimer interface [polypeptide binding]; other site
487521012647	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
487521012648	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
487521012649	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
487521012650	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
487521012651	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
487521012652	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
487521012653	dimer interface [polypeptide binding]; other site
487521012654	putative radical transfer pathway; other site
487521012655	diiron center [ion binding]; other site
487521012656	tyrosyl radical; other site
487521012657	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
487521012658	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
487521012659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521012660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012661	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
487521012662	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
487521012663	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
487521012664	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487521012665	catalytic residues [active]
487521012666	Protein of unknown function (DUF664); Region: DUF664; pfam04978
487521012667	DinB superfamily; Region: DinB_2; pfam12867
487521012668	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
487521012669	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521012670	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
487521012671	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
487521012672	active site
487521012673	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521012674	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521012675	PPE family; Region: PPE; pfam00823
487521012676	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487521012677	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487521012678	classical (c) SDRs; Region: SDR_c; cd05233
487521012679	NAD(P) binding site [chemical binding]; other site
487521012680	active site
487521012681	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
487521012682	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
487521012683	ring oligomerisation interface [polypeptide binding]; other site
487521012684	ATP/Mg binding site [chemical binding]; other site
487521012685	stacking interactions; other site
487521012686	hinge regions; other site
487521012687	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
487521012688	active site
487521012689	Cupin domain; Region: Cupin_2; pfam07883
487521012690	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012691	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
487521012692	short chain dehydrogenase; Provisional; Region: PRK06197
487521012693	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
487521012694	putative NAD(P) binding site [chemical binding]; other site
487521012695	active site
487521012696	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
487521012697	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
487521012698	dimer interface [polypeptide binding]; other site
487521012699	putative functional site; other site
487521012700	putative MPT binding site; other site
487521012701	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
487521012702	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
487521012703	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
487521012704	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
487521012705	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
487521012706	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521012707	Walker A motif; other site
487521012708	ATP binding site [chemical binding]; other site
487521012709	Walker B motif; other site
487521012710	arginine finger; other site
487521012711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521012712	Walker A motif; other site
487521012713	ATP binding site [chemical binding]; other site
487521012714	Walker B motif; other site
487521012715	arginine finger; other site
487521012716	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521012717	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012718	oxidoreductase; Provisional; Region: PRK06196
487521012719	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
487521012720	putative NAD(P) binding site [chemical binding]; other site
487521012721	active site
487521012722	enoyl-CoA hydratase; Provisional; Region: PRK08260
487521012723	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521012724	substrate binding site [chemical binding]; other site
487521012725	oxyanion hole (OAH) forming residues; other site
487521012726	trimer interface [polypeptide binding]; other site
487521012727	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521012728	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521012729	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
487521012730	carboxylate-amine ligase; Provisional; Region: PRK13517
487521012731	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
487521012732	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
487521012733	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
487521012734	E-class dimer interface [polypeptide binding]; other site
487521012735	P-class dimer interface [polypeptide binding]; other site
487521012736	active site
487521012737	Cu2+ binding site [ion binding]; other site
487521012738	Zn2+ binding site [ion binding]; other site
487521012739	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
487521012740	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
487521012741	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
487521012742	active site
487521012743	catalytic residues [active]
487521012744	metal binding site [ion binding]; metal-binding site
487521012745	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
487521012746	putative catalytic site [active]
487521012747	putative phosphate binding site [ion binding]; other site
487521012748	active site
487521012749	metal binding site A [ion binding]; metal-binding site
487521012750	DNA binding site [nucleotide binding]
487521012751	putative AP binding site [nucleotide binding]; other site
487521012752	putative metal binding site B [ion binding]; other site
487521012753	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
487521012754	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521012755	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521012756	motif II; other site
487521012757	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
487521012758	PAS fold; Region: PAS_3; pfam08447
487521012759	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521012760	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
487521012761	ThiC-associated domain; Region: ThiC-associated; pfam13667
487521012762	ThiC family; Region: ThiC; pfam01964
487521012763	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
487521012764	dimer interface [polypeptide binding]; other site
487521012765	substrate binding site [chemical binding]; other site
487521012766	ATP binding site [chemical binding]; other site
487521012767	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
487521012768	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521012769	MarR family; Region: MarR; pfam01047
487521012770	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
487521012771	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521012772	Predicted metalloprotease [General function prediction only]; Region: COG2321
487521012773	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
487521012774	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487521012775	Beta-lactamase; Region: Beta-lactamase; pfam00144
487521012776	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521012777	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521012778	Domain of unknown function (DUF222); Region: DUF222; pfam02720
487521012779	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487521012780	active site
487521012781	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521012782	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521012783	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
487521012784	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487521012785	active site
487521012786	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
487521012787	Peptidase family M23; Region: Peptidase_M23; pfam01551
487521012788	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521012789	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
487521012790	NAD(P) binding site [chemical binding]; other site
487521012791	active site
487521012792	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
487521012793	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
487521012794	PA/protease or protease-like domain interface [polypeptide binding]; other site
487521012795	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
487521012796	Peptidase family M28; Region: Peptidase_M28; pfam04389
487521012797	active site
487521012798	metal binding site [ion binding]; metal-binding site
487521012799	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
487521012800	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
487521012801	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
487521012802	PA/protease or protease-like domain interface [polypeptide binding]; other site
487521012803	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
487521012804	active site
487521012805	metal binding site [ion binding]; metal-binding site
487521012806	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
487521012807	Interferon-induced transmembrane protein; Region: CD225; pfam04505
487521012808	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
487521012809	active site
487521012810	catalytic triad [active]
487521012811	oxyanion hole [active]
487521012812	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
487521012813	ThiS interaction site; other site
487521012814	putative active site [active]
487521012815	tetramer interface [polypeptide binding]; other site
487521012816	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
487521012817	thiS-thiF/thiG interaction site; other site
487521012818	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
487521012819	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
487521012820	thiamine phosphate binding site [chemical binding]; other site
487521012821	active site
487521012822	pyrophosphate binding site [ion binding]; other site
487521012823	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
487521012824	nudix motif; other site
487521012825	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487521012826	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487521012827	substrate binding pocket [chemical binding]; other site
487521012828	membrane-bound complex binding site; other site
487521012829	hinge residues; other site
487521012830	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487521012831	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487521012832	active site
487521012833	ATP binding site [chemical binding]; other site
487521012834	substrate binding site [chemical binding]; other site
487521012835	activation loop (A-loop); other site
487521012836	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
487521012837	putative active site [active]
487521012838	putative transposase OrfB; Reviewed; Region: PHA02517
487521012839	HTH-like domain; Region: HTH_21; pfam13276
487521012840	Integrase core domain; Region: rve; pfam00665
487521012841	Integrase core domain; Region: rve_3; pfam13683
487521012842	Transposase; Region: HTH_Tnp_1; cl17663
487521012843	Helix-turn-helix domain; Region: HTH_38; pfam13936
487521012844	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487521012845	Integrase core domain; Region: rve; pfam00665
487521012846	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
487521012847	propionate/acetate kinase; Provisional; Region: PRK12379
487521012848	phosphate acetyltransferase; Reviewed; Region: PRK05632
487521012849	DRTGG domain; Region: DRTGG; pfam07085
487521012850	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
487521012851	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
487521012852	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
487521012853	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521012854	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487521012855	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521012856	Leucine carboxyl methyltransferase; Region: LCM; cl01306
487521012857	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
487521012858	2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206
487521012859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521012860	NAD(P) binding site [chemical binding]; other site
487521012861	active site
487521012862	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
487521012863	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521012864	FAD binding site [chemical binding]; other site
487521012865	substrate binding pocket [chemical binding]; other site
487521012866	catalytic base [active]
487521012867	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521012868	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521012869	active site
487521012870	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521012871	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521012872	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
487521012873	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521012874	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
487521012875	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
487521012876	homodimer interface [polypeptide binding]; other site
487521012877	substrate-cofactor binding pocket; other site
487521012878	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521012879	catalytic residue [active]
487521012880	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
487521012881	active site residue [active]
487521012882	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
487521012883	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
487521012884	NAD binding site [chemical binding]; other site
487521012885	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487521012886	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521012887	CoenzymeA binding site [chemical binding]; other site
487521012888	subunit interaction site [polypeptide binding]; other site
487521012889	PHB binding site; other site
487521012890	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
487521012891	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
487521012892	GDP-binding site [chemical binding]; other site
487521012893	ACT binding site; other site
487521012894	IMP binding site; other site
487521012895	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
487521012896	catalytic core [active]
487521012897	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
487521012898	Peptidase family M50; Region: Peptidase_M50; pfam02163
487521012899	active site
487521012900	putative substrate binding region [chemical binding]; other site
487521012901	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
487521012902	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
487521012903	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
487521012904	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
487521012905	active site
487521012906	intersubunit interface [polypeptide binding]; other site
487521012907	zinc binding site [ion binding]; other site
487521012908	Na+ binding site [ion binding]; other site
487521012909	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
487521012910	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
487521012911	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
487521012912	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
487521012913	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
487521012914	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
487521012915	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
487521012916	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
487521012917	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487521012918	active site
487521012919	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487521012920	classical (c) SDRs; Region: SDR_c; cd05233
487521012921	NAD(P) binding site [chemical binding]; other site
487521012922	active site
487521012923	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521012924	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521012925	active site
487521012926	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
487521012927	Clp amino terminal domain; Region: Clp_N; pfam02861
487521012928	Clp amino terminal domain; Region: Clp_N; pfam02861
487521012929	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521012930	Walker A motif; other site
487521012931	ATP binding site [chemical binding]; other site
487521012932	Walker B motif; other site
487521012933	arginine finger; other site
487521012934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521012935	Walker A motif; other site
487521012936	ATP binding site [chemical binding]; other site
487521012937	Walker B motif; other site
487521012938	arginine finger; other site
487521012939	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
487521012940	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
487521012941	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
487521012942	heme-binding site [chemical binding]; other site
487521012943	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
487521012944	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
487521012945	FAD binding pocket [chemical binding]; other site
487521012946	FAD binding motif [chemical binding]; other site
487521012947	phosphate binding motif [ion binding]; other site
487521012948	beta-alpha-beta structure motif; other site
487521012949	NAD binding pocket [chemical binding]; other site
487521012950	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
487521012951	active site
487521012952	catalytic residues [active]
487521012953	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
487521012954	DNA binding residues [nucleotide binding]
487521012955	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487521012956	putative dimer interface [polypeptide binding]; other site
487521012957	chaperone protein DnaJ; Provisional; Region: PRK14279
487521012958	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
487521012959	HSP70 interaction site [polypeptide binding]; other site
487521012960	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
487521012961	Zn binding sites [ion binding]; other site
487521012962	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
487521012963	dimer interface [polypeptide binding]; other site
487521012964	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
487521012965	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
487521012966	dimer interface [polypeptide binding]; other site
487521012967	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
487521012968	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
487521012969	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521012970	nucleotide binding site [chemical binding]; other site
487521012971	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
487521012972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521012973	putative substrate translocation pore; other site
487521012974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521012975	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521012976	nucleotide binding site [chemical binding]; other site
487521012977	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
487521012978	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
487521012979	4Fe-4S binding domain; Region: Fer4; pfam00037
487521012980	Cysteine-rich domain; Region: CCG; pfam02754
487521012981	Cysteine-rich domain; Region: CCG; pfam02754
487521012982	aminotransferase AlaT; Validated; Region: PRK09265
487521012983	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487521012984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487521012985	homodimer interface [polypeptide binding]; other site
487521012986	catalytic residue [active]
487521012987	YibE/F-like protein; Region: YibE_F; pfam07907
487521012988	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
487521012989	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
487521012990	substrate binding site; other site
487521012991	tetramer interface; other site
487521012992	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521012993	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
487521012994	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
487521012995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521012996	S-adenosylmethionine binding site [chemical binding]; other site
487521012997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521012998	putative substrate translocation pore; other site
487521012999	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
487521013000	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
487521013001	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
487521013002	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
487521013003	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
487521013004	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
487521013005	trimer interface [polypeptide binding]; other site
487521013006	active site
487521013007	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
487521013008	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
487521013009	Methyltransferase domain; Region: Methyltransf_26; pfam13659
487521013010	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521013011	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487521013012	DNA binding site [nucleotide binding]
487521013013	active site
487521013014	Int/Topo IB signature motif; other site
487521013015	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
487521013016	catalytic residues [active]
487521013017	Recombinase; Region: Recombinase; pfam07508
487521013018	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
487521013019	polymerase nucleotide-binding site; other site
487521013020	DNA-binding residues [nucleotide binding]; DNA binding site
487521013021	nucleotide binding site [chemical binding]; other site
487521013022	primase nucleotide-binding site [nucleotide binding]; other site
487521013023	AAA domain; Region: AAA_25; pfam13481
487521013024	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
487521013025	ATP binding site [chemical binding]; other site
487521013026	Walker B motif; other site
487521013027	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
487521013028	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
487521013029	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
487521013030	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521013031	Emopamil binding protein; Region: EBP; pfam05241
487521013032	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
487521013033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
487521013034	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
487521013035	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521013036	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521013037	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
487521013038	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
487521013039	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
487521013040	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
487521013041	active site
487521013042	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
487521013043	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
487521013044	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
487521013045	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
487521013046	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
487521013047	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
487521013048	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
487521013049	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
487521013050	active site
487521013051	catalytic residues [active]
487521013052	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
487521013053	Prostaglandin dehydrogenases; Region: PGDH; cd05288
487521013054	NAD(P) binding site [chemical binding]; other site
487521013055	substrate binding site [chemical binding]; other site
487521013056	dimer interface [polypeptide binding]; other site
487521013057	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
487521013058	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487521013059	nucleotide binding site [chemical binding]; other site
487521013060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013062	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
487521013063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
487521013064	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
487521013065	active site
487521013066	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
487521013067	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
487521013068	putative FMN binding site [chemical binding]; other site
487521013069	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
487521013070	Sulfatase; Region: Sulfatase; pfam00884
487521013071	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
487521013072	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521013073	S-adenosylmethionine binding site [chemical binding]; other site
487521013074	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521013075	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521013076	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
487521013077	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
487521013078	Subtilase family; Region: Peptidase_S8; pfam00082
487521013079	catalytic residues [active]
487521013080	catalytic residues [active]
487521013081	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
487521013082	EspG family; Region: ESX-1_EspG; pfam14011
487521013083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
487521013084	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521013085	PPE family; Region: PPE; pfam00823
487521013086	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
487521013087	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521013088	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
487521013089	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521013090	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521013091	Protein of unknown function (DUF690); Region: DUF690; pfam05108
487521013092	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
487521013093	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487521013094	Walker A motif; other site
487521013095	ATP binding site [chemical binding]; other site
487521013096	Walker B motif; other site
487521013097	arginine finger; other site
487521013098	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521013099	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521013100	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
487521013101	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
487521013102	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
487521013103	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
487521013104	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
487521013105	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
487521013106	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
487521013107	30S ribosomal protein S18; Provisional; Region: PRK13401
487521013108	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521013109	PPE family; Region: PPE; pfam00823
487521013110	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521013111	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
487521013112	Condensation domain; Region: Condensation; pfam00668
487521013113	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
487521013114	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521013115	Zn binding site [ion binding]; other site
487521013116	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013117	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013118	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521013119	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013120	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521013121	active site
487521013122	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013123	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
487521013124	FAD binding site [chemical binding]; other site
487521013125	substrate binding site [chemical binding]; other site
487521013126	catalytic base [active]
487521013127	acyl-CoA synthetase; Validated; Region: PRK07788
487521013128	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013129	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013130	active site
487521013131	CoA binding site [chemical binding]; other site
487521013132	AMP binding site [chemical binding]; other site
487521013133	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
487521013134	nucleotide binding site [chemical binding]; other site
487521013135	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
487521013136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521013137	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
487521013138	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
487521013139	intersubunit interface [polypeptide binding]; other site
487521013140	Homeodomain-like domain; Region: HTH_23; cl17451
487521013141	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
487521013142	Integrase core domain; Region: rve; pfam00665
487521013143	Integrase core domain; Region: rve_3; pfam13683
487521013144	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
487521013145	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
487521013146	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
487521013147	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
487521013148	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
487521013149	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
487521013150	active site
487521013151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
487521013152	DNA binding site [nucleotide binding]
487521013153	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
487521013154	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
487521013155	putative active site [active]
487521013156	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
487521013157	active site
487521013158	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
487521013159	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
487521013160	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521013161	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
487521013162	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
487521013163	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
487521013164	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
487521013165	putative dimer interface [polypeptide binding]; other site
487521013166	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
487521013167	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
487521013168	tetramer interface [polypeptide binding]; other site
487521013169	active site
487521013170	Mg2+/Mn2+ binding site [ion binding]; other site
487521013171	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
487521013172	L-aspartate oxidase; Provisional; Region: PRK06175
487521013173	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
487521013174	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
487521013175	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521013176	catalytic loop [active]
487521013177	iron binding site [ion binding]; other site
487521013178	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
487521013179	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
487521013180	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
487521013181	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
487521013182	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
487521013183	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
487521013184	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
487521013185	FAD binding site [chemical binding]; other site
487521013186	substrate binding site [chemical binding]; other site
487521013187	catalytic residues [active]
487521013188	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
487521013189	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487521013190	MarR family; Region: MarR_2; pfam12802
487521013191	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487521013192	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
487521013193	active site
487521013194	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
487521013195	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
487521013196	dimer interface [polypeptide binding]; other site
487521013197	active site
487521013198	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
487521013199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013200	NAD(P) binding site [chemical binding]; other site
487521013201	active site
487521013202	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521013203	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521013204	active site 2 [active]
487521013205	active site 1 [active]
487521013206	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
487521013207	Cl- selectivity filter; other site
487521013208	Cl- binding residues [ion binding]; other site
487521013209	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
487521013210	pore gating glutamate residue; other site
487521013211	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013212	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013213	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
487521013214	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
487521013215	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
487521013216	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
487521013217	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
487521013218	Lipase maturation factor; Region: LMF1; pfam06762
487521013219	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
487521013220	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487521013221	substrate binding pocket [chemical binding]; other site
487521013222	membrane-bound complex binding site; other site
487521013223	hinge residues; other site
487521013224	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521013225	PPE family; Region: PPE; pfam00823
487521013226	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
487521013227	PPE family; Region: PPE; pfam00823
487521013228	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
487521013229	Protein of unknown function (DUF732); Region: DUF732; pfam05305
487521013230	formate dehydrogenase; Provisional; Region: PRK07574
487521013231	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
487521013232	dimerization interface [polypeptide binding]; other site
487521013233	ligand binding site [chemical binding]; other site
487521013234	NAD binding site [chemical binding]; other site
487521013235	catalytic site [active]
487521013236	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487521013237	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521013238	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
487521013239	dimerization interface [polypeptide binding]; other site
487521013240	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
487521013241	Protein of unknown function, DUF488; Region: DUF488; pfam04343
487521013242	Helix-turn-helix domain; Region: HTH_20; pfam12840
487521013243	putative DNA binding site [nucleotide binding]; other site
487521013244	Predicted transcriptional regulator [Transcription]; Region: COG2345
487521013245	putative Zn2+ binding site [ion binding]; other site
487521013246	Suppression of tumorigenicity 7; Region: ST7; cd11557
487521013247	Domain of unknown function (DUF309); Region: DUF309; pfam03745
487521013248	acetolactate synthase; Reviewed; Region: PRK08322
487521013249	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487521013250	PYR/PP interface [polypeptide binding]; other site
487521013251	dimer interface [polypeptide binding]; other site
487521013252	TPP binding site [chemical binding]; other site
487521013253	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521013254	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
487521013255	TPP-binding site [chemical binding]; other site
487521013256	dimer interface [polypeptide binding]; other site
487521013257	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
487521013258	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
487521013259	NAD(P) binding site [chemical binding]; other site
487521013260	catalytic residues [active]
487521013261	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
487521013262	active site
487521013263	diiron metal binding site [ion binding]; other site
487521013264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013266	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013267	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
487521013268	active site
487521013269	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
487521013270	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
487521013271	active site
487521013272	substrate binding pocket [chemical binding]; other site
487521013273	homodimer interaction site [polypeptide binding]; other site
487521013274	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013275	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
487521013276	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013277	AMP binding site [chemical binding]; other site
487521013278	active site
487521013279	acyl-activating enzyme (AAE) consensus motif; other site
487521013280	acyl-activating enzyme (AAE) consensus motif; other site
487521013281	CoA binding site [chemical binding]; other site
487521013282	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
487521013283	O-methyltransferase; Region: Methyltransf_2; pfam00891
487521013284	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521013285	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
487521013286	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487521013287	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487521013288	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
487521013289	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
487521013290	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
487521013291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521013292	S-adenosylmethionine binding site [chemical binding]; other site
487521013293	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
487521013294	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521013295	NAD binding site [chemical binding]; other site
487521013296	catalytic residues [active]
487521013297	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013298	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013299	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
487521013300	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013301	acyl-activating enzyme (AAE) consensus motif; other site
487521013302	AMP binding site [chemical binding]; other site
487521013303	active site
487521013304	CoA binding site [chemical binding]; other site
487521013305	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
487521013306	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013307	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013308	enoyl-CoA hydratase; Provisional; Region: PRK08252
487521013309	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521013310	substrate binding site [chemical binding]; other site
487521013311	oxyanion hole (OAH) forming residues; other site
487521013312	trimer interface [polypeptide binding]; other site
487521013313	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
487521013314	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
487521013315	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
487521013316	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521013317	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521013318	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487521013319	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
487521013320	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
487521013321	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521013322	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521013323	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521013324	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521013325	active site
487521013326	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521013327	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521013328	active site 2 [active]
487521013329	active site 1 [active]
487521013330	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
487521013331	active site 2 [active]
487521013332	active site 1 [active]
487521013333	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013334	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521013335	active site
487521013336	Interferon-induced transmembrane protein; Region: CD225; pfam04505
487521013337	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
487521013338	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487521013339	substrate binding site [chemical binding]; other site
487521013340	oxyanion hole (OAH) forming residues; other site
487521013341	trimer interface [polypeptide binding]; other site
487521013342	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
487521013343	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013344	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521013345	acyl-activating enzyme (AAE) consensus motif; other site
487521013346	acyl-activating enzyme (AAE) consensus motif; other site
487521013347	putative AMP binding site [chemical binding]; other site
487521013348	putative active site [active]
487521013349	putative CoA binding site [chemical binding]; other site
487521013350	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
487521013351	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
487521013352	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
487521013353	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
487521013354	metal binding site [ion binding]; metal-binding site
487521013355	active site
487521013356	I-site; other site
487521013357	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
487521013358	active site
487521013359	substrate-binding site [chemical binding]; other site
487521013360	metal-binding site [ion binding]
487521013361	GTP binding site [chemical binding]; other site
487521013362	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521013363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521013364	S-adenosylmethionine binding site [chemical binding]; other site
487521013365	LabA_like proteins; Region: LabA_like; cd06167
487521013366	putative metal binding site [ion binding]; other site
487521013367	MMPL family; Region: MMPL; pfam03176
487521013368	MMPL family; Region: MMPL; pfam03176
487521013369	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
487521013370	Domain of unknown function DUF20; Region: UPF0118; pfam01594
487521013371	Predicted integral membrane protein [Function unknown]; Region: COG0392
487521013372	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
487521013373	Protein export membrane protein; Region: SecD_SecF; cl14618
487521013374	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
487521013375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
487521013376	non-specific DNA binding site [nucleotide binding]; other site
487521013377	salt bridge; other site
487521013378	sequence-specific DNA binding site [nucleotide binding]; other site
487521013379	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
487521013380	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
487521013381	active site
487521013382	Zn binding site [ion binding]; other site
487521013383	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
487521013384	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521013385	molybdopterin cofactor binding site; other site
487521013386	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
487521013387	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
487521013388	putative molybdopterin cofactor binding site; other site
487521013389	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013390	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
487521013392	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
487521013393	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
487521013394	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
487521013395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487521013396	putative substrate translocation pore; other site
487521013397	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
487521013398	putative homodimer interface [polypeptide binding]; other site
487521013399	putative homotetramer interface [polypeptide binding]; other site
487521013400	putative allosteric switch controlling residues; other site
487521013401	putative metal binding site [ion binding]; other site
487521013402	putative homodimer-homodimer interface [polypeptide binding]; other site
487521013403	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
487521013404	6-phosphogluconate dehydratase; Region: edd; TIGR01196
487521013405	SPW repeat; Region: SPW; pfam03779
487521013406	SPW repeat; Region: SPW; pfam03779
487521013407	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487521013408	FMN binding site [chemical binding]; other site
487521013409	substrate binding site [chemical binding]; other site
487521013410	putative catalytic residue [active]
487521013411	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
487521013412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521013413	S-adenosylmethionine binding site [chemical binding]; other site
487521013414	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
487521013415	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
487521013416	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
487521013417	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
487521013418	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
487521013419	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
487521013420	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
487521013421	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521013422	RNA polymerase factor sigma-70; Validated; Region: PRK08241
487521013423	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521013424	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
487521013425	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521013426	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521013427	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521013428	Bacterial transcriptional regulator; Region: IclR; pfam01614
487521013429	Pirin-related protein [General function prediction only]; Region: COG1741
487521013430	Pirin; Region: Pirin; pfam02678
487521013431	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
487521013432	Protein of unknown function (DUF3533); Region: DUF3533; pfam12051
487521013433	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
487521013434	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
487521013435	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
487521013436	RDD family; Region: RDD; pfam06271
487521013437	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521013438	mce related protein; Region: MCE; pfam02470
487521013439	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521013440	mce related protein; Region: MCE; pfam02470
487521013441	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521013442	mce related protein; Region: MCE; pfam02470
487521013443	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521013444	mce related protein; Region: MCE; pfam02470
487521013445	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521013446	mce related protein; Region: MCE; pfam02470
487521013447	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
487521013448	mce related protein; Region: MCE; pfam02470
487521013449	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
487521013450	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521013451	Permease; Region: Permease; pfam02405
487521013452	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
487521013453	Permease; Region: Permease; pfam02405
487521013454	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
487521013455	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013456	acyl-activating enzyme (AAE) consensus motif; other site
487521013457	AMP binding site [chemical binding]; other site
487521013458	active site
487521013459	CoA binding site [chemical binding]; other site
487521013460	Transcriptional regulators [Transcription]; Region: GntR; COG1802
487521013461	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521013462	DNA-binding site [nucleotide binding]; DNA binding site
487521013463	FCD domain; Region: FCD; pfam07729
487521013464	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
487521013465	putative hydrophobic ligand binding site [chemical binding]; other site
487521013466	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
487521013467	active site
487521013468	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
487521013469	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487521013470	NAD(P) binding site [chemical binding]; other site
487521013471	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
487521013472	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
487521013473	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521013474	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521013475	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
487521013476	classical (c) SDRs; Region: SDR_c; cd05233
487521013477	NAD(P) binding site [chemical binding]; other site
487521013478	active site
487521013479	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
487521013480	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
487521013481	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487521013482	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521013483	NAD(P) binding site [chemical binding]; other site
487521013484	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521013485	Cytochrome P450; Region: p450; cl12078
487521013486	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521013487	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521013488	short chain dehydrogenase; Validated; Region: PRK08264
487521013489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013490	NAD(P) binding site [chemical binding]; other site
487521013491	active site
487521013492	Domain of unknown function (DUF427); Region: DUF427; cl00998
487521013493	Domain of unknown function (DUF427); Region: DUF427; pfam04248
487521013494	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013495	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521013496	active site
487521013497	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
487521013498	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
487521013499	acyl-CoA thioesterase II; Region: tesB; TIGR00189
487521013500	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
487521013501	active site
487521013502	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
487521013503	catalytic triad [active]
487521013504	dimer interface [polypeptide binding]; other site
487521013505	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521013506	hydrophobic ligand binding site; other site
487521013507	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
487521013508	Strictosidine synthase; Region: Str_synth; pfam03088
487521013509	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487521013510	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013511	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013512	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
487521013513	FAD binding domain; Region: FAD_binding_4; pfam01565
487521013514	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013515	NAD(P) binding site [chemical binding]; other site
487521013516	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521013517	active site
487521013518	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
487521013519	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
487521013520	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
487521013521	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013522	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013523	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
487521013524	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
487521013525	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
487521013526	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
487521013527	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
487521013528	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
487521013529	ligand binding site [chemical binding]; other site
487521013530	homodimer interface [polypeptide binding]; other site
487521013531	NAD(P) binding site [chemical binding]; other site
487521013532	trimer interface B [polypeptide binding]; other site
487521013533	trimer interface A [polypeptide binding]; other site
487521013534	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
487521013535	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521013536	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013537	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
487521013538	FAD binding site [chemical binding]; other site
487521013539	substrate binding site [chemical binding]; other site
487521013540	catalytic base [active]
487521013541	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
487521013542	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
487521013543	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
487521013544	short chain dehydrogenase; Provisional; Region: PRK07791
487521013545	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
487521013546	NAD binding site [chemical binding]; other site
487521013547	homodimer interface [polypeptide binding]; other site
487521013548	active site
487521013549	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
487521013550	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
487521013551	NAD(P) binding site [chemical binding]; other site
487521013552	catalytic residues [active]
487521013553	Transcriptional regulator [Transcription]; Region: LytR; COG1316
487521013554	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
487521013555	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521013556	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521013557	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521013558	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
487521013559	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013561	Pirin-related protein [General function prediction only]; Region: COG1741
487521013562	Pirin; Region: Pirin; pfam02678
487521013563	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
487521013564	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
487521013565	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
487521013566	dimerization interface [polypeptide binding]; other site
487521013567	DPS ferroxidase diiron center [ion binding]; other site
487521013568	ion pore; other site
487521013569	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
487521013570	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
487521013571	minor groove reading motif; other site
487521013572	helix-hairpin-helix signature motif; other site
487521013573	active site
487521013574	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
487521013575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
487521013576	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
487521013577	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
487521013578	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
487521013579	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013580	NAD(P) binding site [chemical binding]; other site
487521013581	active site
487521013582	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521013583	methionine sulfoxide reductase A; Provisional; Region: PRK14054
487521013584	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
487521013585	Cytochrome P450; Region: p450; cl12078
487521013586	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013587	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013588	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
487521013589	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521013590	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
487521013591	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013592	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013593	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521013594	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
487521013595	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521013596	hydrophobic ligand binding site; other site
487521013597	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
487521013598	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
487521013599	putative di-iron ligands [ion binding]; other site
487521013600	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
487521013601	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
487521013602	FAD binding pocket [chemical binding]; other site
487521013603	FAD binding motif [chemical binding]; other site
487521013604	phosphate binding motif [ion binding]; other site
487521013605	beta-alpha-beta structure motif; other site
487521013606	NAD binding pocket [chemical binding]; other site
487521013607	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
487521013608	catalytic loop [active]
487521013609	iron binding site [ion binding]; other site
487521013610	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
487521013611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013612	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
487521013613	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
487521013614	Coenzyme A binding pocket [chemical binding]; other site
487521013615	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
487521013616	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
487521013617	Hemerythrin-like domain; Region: Hr-like; cd12108
487521013618	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
487521013619	dimanganese center [ion binding]; other site
487521013620	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
487521013621	GAF domain; Region: GAF; pfam01590
487521013622	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
487521013623	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
487521013624	putative active site [active]
487521013625	putative catalytic site [active]
487521013626	Domain of unknown function DUF302; Region: DUF302; pfam03625
487521013627	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
487521013628	active site
487521013629	metal binding site [ion binding]; metal-binding site
487521013630	homotetramer interface [polypeptide binding]; other site
487521013631	MarR family; Region: MarR_2; pfam12802
487521013632	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
487521013633	Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265
487521013634	Walker A/P-loop; other site
487521013635	ATP binding site [chemical binding]; other site
487521013636	Q-loop/lid; other site
487521013637	ABC transporter signature motif; other site
487521013638	Walker B; other site
487521013639	D-loop; other site
487521013640	H-loop/switch region; other site
487521013641	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487521013642	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
487521013643	Predicted esterase [General function prediction only]; Region: COG0627
487521013644	Predicted membrane protein [Function unknown]; Region: COG3619
487521013645	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
487521013646	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
487521013647	trehalose synthase; Region: treS_nterm; TIGR02456
487521013648	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
487521013649	active site
487521013650	catalytic site [active]
487521013651	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
487521013652	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
487521013653	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
487521013654	protein binding site [polypeptide binding]; other site
487521013655	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
487521013656	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
487521013657	elongation factor G; Reviewed; Region: PRK12740
487521013658	G1 box; other site
487521013659	putative GEF interaction site [polypeptide binding]; other site
487521013660	GTP/Mg2+ binding site [chemical binding]; other site
487521013661	Switch I region; other site
487521013662	G2 box; other site
487521013663	G3 box; other site
487521013664	Switch II region; other site
487521013665	G4 box; other site
487521013666	G5 box; other site
487521013667	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
487521013668	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
487521013669	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
487521013670	acyl-CoA synthetase; Validated; Region: PRK05852
487521013671	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013672	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013673	acyl-activating enzyme (AAE) consensus motif; other site
487521013674	acyl-activating enzyme (AAE) consensus motif; other site
487521013675	AMP binding site [chemical binding]; other site
487521013676	active site
487521013677	CoA binding site [chemical binding]; other site
487521013678	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
487521013679	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487521013680	PYR/PP interface [polypeptide binding]; other site
487521013681	dimer interface [polypeptide binding]; other site
487521013682	TPP binding site [chemical binding]; other site
487521013683	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521013684	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
487521013685	TPP-binding site; other site
487521013686	dimer interface [polypeptide binding]; other site
487521013687	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487521013688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521013689	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
487521013690	dimerization interface [polypeptide binding]; other site
487521013691	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
487521013692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
487521013693	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
487521013694	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
487521013695	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013696	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013697	acyl-activating enzyme (AAE) consensus motif; other site
487521013698	acyl-activating enzyme (AAE) consensus motif; other site
487521013699	AMP binding site [chemical binding]; other site
487521013700	active site
487521013701	CoA binding site [chemical binding]; other site
487521013702	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
487521013703	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
487521013704	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
487521013705	putative NAD(P) binding site [chemical binding]; other site
487521013706	active site
487521013707	putative substrate binding site [chemical binding]; other site
487521013708	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
487521013709	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
487521013710	putative NAD(P) binding site [chemical binding]; other site
487521013711	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
487521013712	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
487521013713	Methyltransferase domain; Region: Methyltransf_24; pfam13578
487521013714	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521013715	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487521013716	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
487521013717	active site
487521013718	catalytic triad [active]
487521013719	oxyanion hole [active]
487521013720	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
487521013721	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
487521013722	NAD binding site [chemical binding]; other site
487521013723	catalytic residues [active]
487521013724	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
487521013725	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487521013726	PYR/PP interface [polypeptide binding]; other site
487521013727	dimer interface [polypeptide binding]; other site
487521013728	TPP binding site [chemical binding]; other site
487521013729	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487521013730	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
487521013731	TPP-binding site; other site
487521013732	dimer interface [polypeptide binding]; other site
487521013733	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521013734	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521013735	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013736	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521013737	NAD(P) binding site [chemical binding]; other site
487521013738	active site
487521013739	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521013740	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521013741	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521013742	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521013743	[2Fe-2S] cluster binding site [ion binding]; other site
487521013744	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
487521013745	putative alpha subunit interface [polypeptide binding]; other site
487521013746	putative active site [active]
487521013747	putative substrate binding site [chemical binding]; other site
487521013748	Fe binding site [ion binding]; other site
487521013749	classical (c) SDRs; Region: SDR_c; cd05233
487521013750	NAD(P) binding site [chemical binding]; other site
487521013751	active site
487521013752	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
487521013753	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
487521013754	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487521013755	DNA-binding site [nucleotide binding]; DNA binding site
487521013756	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
487521013757	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
487521013758	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
487521013759	acyl-activating enzyme (AAE) consensus motif; other site
487521013760	putative AMP binding site [chemical binding]; other site
487521013761	putative active site [active]
487521013762	putative CoA binding site [chemical binding]; other site
487521013763	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
487521013764	classical (c) SDRs; Region: SDR_c; cd05233
487521013765	NAD(P) binding site [chemical binding]; other site
487521013766	active site
487521013767	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
487521013768	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013769	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
487521013770	acyl-activating enzyme (AAE) consensus motif; other site
487521013771	acyl-activating enzyme (AAE) consensus motif; other site
487521013772	putative AMP binding site [chemical binding]; other site
487521013773	putative active site [active]
487521013774	putative CoA binding site [chemical binding]; other site
487521013775	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
487521013776	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
487521013777	NAD binding site [chemical binding]; other site
487521013778	catalytic Zn binding site [ion binding]; other site
487521013779	substrate binding site [chemical binding]; other site
487521013780	structural Zn binding site [ion binding]; other site
487521013781	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
487521013782	hydrophobic ligand binding site; other site
487521013783	SnoaL-like domain; Region: SnoaL_2; pfam12680
487521013784	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
487521013785	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013786	NAD(P) binding site [chemical binding]; other site
487521013787	active site
487521013788	RNA polymerase factor sigma-70; Validated; Region: PRK08241
487521013789	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521013790	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521013791	DNA binding residues [nucleotide binding]
487521013792	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487521013793	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521013794	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
487521013795	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
487521013796	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487521013797	motif II; other site
487521013798	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
487521013799	acyl-CoA synthetase; Provisional; Region: PRK13383
487521013800	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013801	acyl-activating enzyme (AAE) consensus motif; other site
487521013802	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013803	AMP binding site [chemical binding]; other site
487521013804	active site
487521013805	acyl-activating enzyme (AAE) consensus motif; other site
487521013806	CoA binding site [chemical binding]; other site
487521013807	short chain dehydrogenase; Provisional; Region: PRK07825
487521013808	classical (c) SDRs; Region: SDR_c; cd05233
487521013809	NAD(P) binding site [chemical binding]; other site
487521013810	active site
487521013811	Cutinase; Region: Cutinase; pfam01083
487521013812	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
487521013813	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
487521013814	putative NAD(P) binding site [chemical binding]; other site
487521013815	active site
487521013816	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
487521013817	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013818	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013819	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521013820	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
487521013821	cyclase homology domain; Region: CHD; cd07302
487521013822	nucleotidyl binding site; other site
487521013823	metal binding site [ion binding]; metal-binding site
487521013824	dimer interface [polypeptide binding]; other site
487521013825	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521013826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521013827	S-adenosylmethionine binding site [chemical binding]; other site
487521013828	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
487521013829	hydrophobic ligand binding site; other site
487521013830	short chain dehydrogenase; Validated; Region: PRK08264
487521013831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013832	NAD(P) binding site [chemical binding]; other site
487521013833	active site
487521013834	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
487521013835	CGNR zinc finger; Region: zf-CGNR; pfam11706
487521013836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487521013837	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487521013838	S-adenosylmethionine binding site [chemical binding]; other site
487521013839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013840	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
487521013841	NAD(P) binding site [chemical binding]; other site
487521013842	active site
487521013843	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487521013844	CoenzymeA binding site [chemical binding]; other site
487521013845	subunit interaction site [polypeptide binding]; other site
487521013846	PHB binding site; other site
487521013847	Predicted membrane protein [Function unknown]; Region: COG3305
487521013848	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
487521013849	2-methylcitrate dehydratase; Region: prpD; TIGR02330
487521013850	Transcriptional regulator [Transcription]; Region: IclR; COG1414
487521013851	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
487521013852	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
487521013853	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487521013854	putative NAD(P) binding site [chemical binding]; other site
487521013855	catalytic Zn binding site [ion binding]; other site
487521013856	SnoaL-like domain; Region: SnoaL_4; pfam13577
487521013857	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013858	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
487521013859	NAD(P) binding site [chemical binding]; other site
487521013860	active site
487521013861	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
487521013862	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
487521013863	short chain dehydrogenase; Provisional; Region: PRK06940
487521013864	classical (c) SDRs; Region: SDR_c; cd05233
487521013865	NAD(P) binding site [chemical binding]; other site
487521013866	active site
487521013867	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
487521013868	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
487521013869	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521013870	Protein of unknown function, DUF417; Region: DUF417; cl01162
487521013871	tetracycline repressor protein TetR; Provisional; Region: PRK13756
487521013872	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013873	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
487521013874	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
487521013875	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
487521013876	putative hydrophobic ligand binding site [chemical binding]; other site
487521013877	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487521013878	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487521013879	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
487521013880	dimerization interface [polypeptide binding]; other site
487521013881	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
487521013882	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487521013883	NAD(P) binding site [chemical binding]; other site
487521013884	active site
487521013885	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
487521013886	classical (c) SDRs; Region: SDR_c; cd05233
487521013887	NAD(P) binding site [chemical binding]; other site
487521013888	active site
487521013889	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
487521013890	classical (c) SDRs; Region: SDR_c; cd05233
487521013891	NAD(P) binding site [chemical binding]; other site
487521013892	active site
487521013893	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
487521013894	metal-binding site [ion binding]
487521013895	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
487521013896	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
487521013897	metal-binding site [ion binding]
487521013898	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487521013899	Predicted esterase [General function prediction only]; Region: COG0627
487521013900	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
487521013901	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
487521013902	NodB motif; other site
487521013903	active site
487521013904	catalytic site [active]
487521013905	metal binding site [ion binding]; metal-binding site
487521013906	Secretory lipase; Region: LIP; pfam03583
487521013907	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
487521013908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
487521013909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013911	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487521013912	classical (c) SDRs; Region: SDR_c; cd05233
487521013913	NAD(P) binding site [chemical binding]; other site
487521013914	active site
487521013915	acyl-CoA synthetase; Provisional; Region: PRK13388
487521013916	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
487521013917	acyl-activating enzyme (AAE) consensus motif; other site
487521013918	AMP binding site [chemical binding]; other site
487521013919	active site
487521013920	CoA binding site [chemical binding]; other site
487521013921	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521013922	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521013923	active site
487521013924	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521013925	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521013926	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
487521013927	CoA-transferase family III; Region: CoA_transf_3; pfam02515
487521013928	Amidohydrolase; Region: Amidohydro_2; pfam04909
487521013929	Transcriptional regulators [Transcription]; Region: PurR; COG1609
487521013930	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487521013931	DNA binding site [nucleotide binding]
487521013932	domain linker motif; other site
487521013933	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
487521013934	dimerization interface [polypeptide binding]; other site
487521013935	ligand binding site [chemical binding]; other site
487521013936	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
487521013937	DUF35 OB-fold domain; Region: DUF35; pfam01796
487521013938	acetyl-CoA acetyltransferase; Provisional; Region: PRK08142
487521013939	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
487521013940	active site
487521013941	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013942	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
487521013943	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521013944	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
487521013945	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
487521013946	active site
487521013947	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013948	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013949	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
487521013950	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013951	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
487521013952	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
487521013953	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
487521013954	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
487521013955	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
487521013956	Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949
487521013957	putative active site [active]
487521013958	catalytic residue [active]
487521013959	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
487521013960	anti sigma factor interaction site; other site
487521013961	regulatory phosphorylation site [posttranslational modification]; other site
487521013962	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
487521013963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
487521013964	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
487521013965	Phosphotransferase enzyme family; Region: APH; pfam01636
487521013966	putative active site [active]
487521013967	ATP binding site [chemical binding]; other site
487521013968	putative substrate binding site [chemical binding]; other site
487521013969	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487521013970	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487521013971	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
487521013972	Phosphotransferase enzyme family; Region: APH; pfam01636
487521013973	Ecdysteroid kinase; Region: EcKinase; cl17738
487521013974	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
487521013975	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
487521013976	active site
487521013977	putative substrate binding pocket [chemical binding]; other site
487521013978	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487521013979	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
487521013980	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
487521013981	[2Fe-2S] cluster binding site [ion binding]; other site
487521013982	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
487521013983	putative alpha subunit interface [polypeptide binding]; other site
487521013984	putative active site [active]
487521013985	putative substrate binding site [chemical binding]; other site
487521013986	Fe binding site [ion binding]; other site
487521013987	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487521013988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487521013989	active site
487521013990	phosphorylation site [posttranslational modification]
487521013991	intermolecular recognition site; other site
487521013992	dimerization interface [polypeptide binding]; other site
487521013993	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487521013994	DNA binding residues [nucleotide binding]
487521013995	dimerization interface [polypeptide binding]; other site
487521013996	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
487521013997	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
487521013998	Transport protein; Region: actII; TIGR00833
487521013999	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
487521014000	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521014001	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
487521014002	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521014003	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487521014004	Protein of unknown function (DUF690); Region: DUF690; pfam05108
487521014005	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
487521014006	catalytic residue [active]
487521014007	Protein of unknown function (DUF2563); Region: DUF2563; pfam10817
487521014008	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
487521014009	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
487521014010	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
487521014011	active site
487521014012	NTP binding site [chemical binding]; other site
487521014013	metal binding triad [ion binding]; metal-binding site
487521014014	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
487521014015	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487521014016	Zn2+ binding site [ion binding]; other site
487521014017	Mg2+ binding site [ion binding]; other site
487521014018	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
487521014019	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
487521014020	active site
487521014021	Ap6A binding site [chemical binding]; other site
487521014022	nudix motif; other site
487521014023	metal binding site [ion binding]; metal-binding site
487521014024	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
487521014025	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
487521014026	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
487521014027	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487521014028	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487521014029	DNA binding residues [nucleotide binding]
487521014030	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
487521014031	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487521014032	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487521014033	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
487521014034	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
487521014035	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
487521014036	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
487521014037	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
487521014038	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
487521014039	active site
487521014040	metal binding site [ion binding]; metal-binding site
487521014041	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
487521014042	ParB-like nuclease domain; Region: ParBc; pfam02195
487521014043	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
487521014044	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
487521014045	P-loop; other site
487521014046	Magnesium ion binding site [ion binding]; other site
487521014047	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
487521014048	Magnesium ion binding site [ion binding]; other site
487521014049	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
487521014050	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
487521014051	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
487521014052	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
487521014053	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
487521014054	G-X-X-G motif; other site
487521014055	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
487521014056	RxxxH motif; other site
487521014057	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
487521014058	Ribonuclease P; Region: Ribonuclease_P; cl00457