-- dump date   	20140619_151314
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
233413000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
233413000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413000003	Walker A motif; other site
233413000004	ATP binding site [chemical binding]; other site
233413000005	Walker B motif; other site
233413000006	arginine finger; other site
233413000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
233413000008	DnaA box-binding interface [nucleotide binding]; other site
233413000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
233413000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
233413000011	putative DNA binding surface [nucleotide binding]; other site
233413000012	dimer interface [polypeptide binding]; other site
233413000013	beta-clamp/clamp loader binding surface; other site
233413000014	beta-clamp/translesion DNA polymerase binding surface; other site
233413000015	recF protein; Region: recf; TIGR00611
233413000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
233413000017	Walker A/P-loop; other site
233413000018	ATP binding site [chemical binding]; other site
233413000019	Q-loop/lid; other site
233413000020	ABC transporter signature motif; other site
233413000021	Walker B; other site
233413000022	D-loop; other site
233413000023	H-loop/switch region; other site
233413000024	hypothetical protein; Provisional; Region: PRK03195
233413000025	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
233413000026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413000027	ATP binding site [chemical binding]; other site
233413000028	Mg2+ binding site [ion binding]; other site
233413000029	G-X-G motif; other site
233413000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
233413000031	anchoring element; other site
233413000032	dimer interface [polypeptide binding]; other site
233413000033	ATP binding site [chemical binding]; other site
233413000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
233413000035	active site
233413000036	putative metal-binding site [ion binding]; other site
233413000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
233413000038	DNA gyrase subunit A; Validated; Region: PRK05560
233413000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
233413000040	CAP-like domain; other site
233413000041	active site
233413000042	primary dimer interface [polypeptide binding]; other site
233413000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
233413000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
233413000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
233413000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
233413000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
233413000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
233413000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
233413000050	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
233413000051	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
233413000052	active site
233413000053	Bacterial PH domain; Region: bPH_6; pfam10756
233413000054	putative septation inhibitor protein; Reviewed; Region: PRK00159
233413000055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
233413000056	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
233413000057	Glutamine amidotransferase class-I; Region: GATase; pfam00117
233413000058	glutamine binding [chemical binding]; other site
233413000059	catalytic triad [active]
233413000060	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
233413000061	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413000062	active site
233413000063	ATP binding site [chemical binding]; other site
233413000064	substrate binding site [chemical binding]; other site
233413000065	activation loop (A-loop); other site
233413000066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
233413000067	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
233413000068	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
233413000069	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
233413000070	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
233413000071	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413000072	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413000073	active site
233413000074	ATP binding site [chemical binding]; other site
233413000075	substrate binding site [chemical binding]; other site
233413000076	activation loop (A-loop); other site
233413000077	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
233413000078	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
233413000079	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
233413000080	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
233413000081	active site
233413000082	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
233413000083	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413000084	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413000085	phosphopeptide binding site; other site
233413000086	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
233413000087	Arsenite-resistance protein 2; Region: ARS2; pfam04959
233413000088	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413000089	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413000090	phosphopeptide binding site; other site
233413000091	Nitronate monooxygenase; Region: NMO; pfam03060
233413000092	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
233413000093	FMN binding site [chemical binding]; other site
233413000094	substrate binding site [chemical binding]; other site
233413000095	putative catalytic residue [active]
233413000096	Transcription factor WhiB; Region: Whib; pfam02467
233413000097	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
233413000098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413000099	non-specific DNA binding site [nucleotide binding]; other site
233413000100	salt bridge; other site
233413000101	sequence-specific DNA binding site [nucleotide binding]; other site
233413000102	Mb0025, -, len: 89 aa. Equivalent to 3' end of Rv0024, len: 281 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 89 aa overlap). secreted protein, p60 homologue, similar in part to others and relatives proteins e.g. P60_LISIV|Q01837 protein p60 precursor (invasion-associated protein) from Listeria ivanovii (524 aa), FASTA scores: opt: 245, E(): 1.5e-08, (37.0% identity in 100 aa overlap); CAB92656.1|AL356832 NPL/P60 family secreted protein from Streptomyces coelicolor (347 aa) ; etc. Similar to Mycobacterium tuberculosis proteins Rv1477, Rv1478, Rv1566c, Rv2190c. And several homologues in Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517 probable secreted protein (338 aa), FASTA scores: opt: 399, E(): 9.8e-18, (34.9% identity in 292 aa overlap). COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0024 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts, Mb0024 and Mb0025.; SECRETED PROTEIN P60-RELATED PROTEIN [SECOND PART]
233413000103	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
233413000104	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
233413000105	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
233413000106	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
233413000107	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
233413000108	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
233413000109	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
233413000110	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
233413000111	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413000112	catalytic residue [active]
233413000113	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
233413000114	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
233413000115	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
233413000116	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413000117	acyl-activating enzyme (AAE) consensus motif; other site
233413000118	active site
233413000119	TIGR03084 family protein; Region: TIGR03084
233413000120	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
233413000121	Wyosine base formation; Region: Wyosine_form; pfam08608
233413000122	H+ Antiporter protein; Region: 2A0121; TIGR00900
233413000123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413000124	putative substrate translocation pore; other site
233413000125	hypothetical protein; Validated; Region: PRK00228
233413000126	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
233413000127	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
233413000128	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
233413000129	active site
233413000130	HIGH motif; other site
233413000131	nucleotide binding site [chemical binding]; other site
233413000132	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
233413000133	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
233413000134	active site
233413000135	KMSKS motif; other site
233413000136	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
233413000137	tRNA binding surface [nucleotide binding]; other site
233413000138	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413000139	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
233413000140	Transcriptional regulators [Transcription]; Region: GntR; COG1802
233413000141	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
233413000142	DNA-binding site [nucleotide binding]; DNA binding site
233413000143	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413000144	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413000145	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413000146	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413000147	inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450
233413000148	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
233413000149	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
233413000150	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
233413000151	Transglycosylase; Region: Transgly; pfam00912
233413000152	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
233413000153	Predicted integral membrane protein [Function unknown]; Region: COG5650
233413000154	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
233413000155	conserved cys residue [active]
233413000156	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
233413000157	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
233413000158	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
233413000159	dimer interface [polypeptide binding]; other site
233413000160	ssDNA binding site [nucleotide binding]; other site
233413000161	tetramer (dimer of dimers) interface [polypeptide binding]; other site
233413000162	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
233413000163	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
233413000164	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
233413000165	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
233413000166	replicative DNA helicase; Validated; Region: PRK07773
233413000167	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
233413000168	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
233413000169	Walker A motif; other site
233413000170	ATP binding site [chemical binding]; other site
233413000171	Walker B motif; other site
233413000172	DNA binding loops [nucleotide binding]
233413000173	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
233413000174	protein-splicing catalytic site; other site
233413000175	thioester formation/cholesterol transfer; other site
233413000176	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
233413000177	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
233413000178	protein-splicing catalytic site; other site
233413000179	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
233413000180	Domain of unknown function (DUF4433); Region: DUF4433; pfam14487
233413000181	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
233413000182	ADP-ribose binding site [chemical binding]; other site
233413000183	Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110
233413000184	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
233413000185	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413000186	FAD binding domain; Region: FAD_binding_4; pfam01565
233413000187	Berberine and berberine like; Region: BBE; pfam08031
233413000188	hypothetical protein; Provisional; Region: PRK12438
233413000189	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
233413000190	homotetrameric interface [polypeptide binding]; other site
233413000191	putative active site [active]
233413000192	metal binding site [ion binding]; metal-binding site
233413000193	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
233413000194	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000195	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000196	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
233413000197	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
233413000198	putative NAD(P) binding site [chemical binding]; other site
233413000199	active site
233413000200	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
233413000201	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
233413000202	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
233413000203	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
233413000204	dimer interface [polypeptide binding]; other site
233413000205	active site
233413000206	glycine-pyridoxal phosphate binding site [chemical binding]; other site
233413000207	folate binding site [chemical binding]; other site
233413000208	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
233413000209	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
233413000210	putative NTP binding site [chemical binding]; other site
233413000211	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
233413000212	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
233413000213	FtsX-like permease family; Region: FtsX; pfam02687
233413000214	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
233413000215	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
233413000216	Walker A/P-loop; other site
233413000217	ATP binding site [chemical binding]; other site
233413000218	Q-loop/lid; other site
233413000219	ABC transporter signature motif; other site
233413000220	Walker B; other site
233413000221	D-loop; other site
233413000222	H-loop/switch region; other site
233413000223	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
233413000224	Mb0075, -, len: 70 aa. Equivalent to 3' end of Rv0073, len: 330 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 70 aa overlap). Probable glutamine-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. NP_070646.1|NC_000917 ABC transporter ATP-binding protein from Archaeoglobus fulgidus (231 aa); T34822 ABC-transporter ATP binding protein from Streptomyces coelicolor (230 aa); YBJZ_ECOLI|P75831 hypothetical ABC transporter ATP-binding protein from Escherichia coli (648 aa), FASTA scores: opt: 531, E(): 6.8e-30, (38.6% identity in 233 aa overlap); etc. Also highly similar to Y0A4_MYCT|Q50734|MTCY9C4.04c hypothetical ABC transporter ATP-binding protein from Mycobacterium tuberculosis (330 aa), FASTA scores: E(): 0, (83.3% identity in 330 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop), PS00211 ABC transporters family signature, and PS00889 Cyclic nucleotide-binding domain signature 2. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Note that supposed act with near ORF Rv0072|MTV030.16 transmembrane ABC-transporter. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075.;PROBABLE GLUTAMINE-TRANSPORT PROTEIN ABC TRANSPORTER GLNQ
233413000225	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
233413000226	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
233413000227	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
233413000228	active site
233413000229	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
233413000230	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413000231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413000232	homodimer interface [polypeptide binding]; other site
233413000233	catalytic residue [active]
233413000234	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413000235	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413000236	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000237	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000238	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
233413000239	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
233413000240	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413000241	dimerization interface [polypeptide binding]; other site
233413000242	putative DNA binding site [nucleotide binding]; other site
233413000243	putative Zn2+ binding site [ion binding]; other site
233413000244	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
233413000245	hydrogenase 4 subunit B; Validated; Region: PRK06521
233413000246	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
233413000247	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
233413000248	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237
233413000249	hydrogenase 4 subunit F; Validated; Region: PRK06458
233413000250	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
233413000251	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
233413000252	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
233413000253	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
233413000254	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
233413000255	putative hydrophobic ligand binding site [chemical binding]; other site
233413000256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413000257	S-adenosylmethionine binding site [chemical binding]; other site
233413000258	Predicted membrane protein [Function unknown]; Region: COG3305
233413000259	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
233413000260	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
233413000261	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
233413000262	metal-binding site [ion binding]
233413000263	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413000264	Soluble P-type ATPase [General function prediction only]; Region: COG4087
233413000265	Predicted integral membrane protein [Function unknown]; Region: COG5660
233413000266	Putative zinc-finger; Region: zf-HC2; pfam13490
233413000267	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413000268	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413000269	active site
233413000270	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413000271	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000272	PPE family; Region: PPE; pfam00823
233413000273	Gammaherpesvirus capsid protein; Region: Herpes_capsid; pfam06112
233413000274	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
233413000275	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
233413000276	FcoT-like thioesterase domain; Region: FcoT; pfam10862
233413000277	acyl-CoA synthetase; Validated; Region: PRK05857
233413000278	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
233413000279	acyl-activating enzyme (AAE) consensus motif; other site
233413000280	AMP binding site [chemical binding]; other site
233413000281	active site
233413000282	CoA binding site [chemical binding]; other site
233413000283	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413000284	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413000285	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
233413000286	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413000287	acyl-activating enzyme (AAE) consensus motif; other site
233413000288	acyl-activating enzyme (AAE) consensus motif; other site
233413000289	AMP binding site [chemical binding]; other site
233413000290	active site
233413000291	CoA binding site [chemical binding]; other site
233413000292	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413000293	Condensation domain; Region: Condensation; pfam00668
233413000294	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
233413000295	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
233413000296	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
233413000297	acyl-activating enzyme (AAE) consensus motif; other site
233413000298	AMP binding site [chemical binding]; other site
233413000299	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413000300	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
233413000301	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
233413000302	putative NAD(P) binding site [chemical binding]; other site
233413000303	active site
233413000304	putative substrate binding site [chemical binding]; other site
233413000305	Predicted membrane protein [Function unknown]; Region: COG3336
233413000306	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
233413000307	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
233413000308	metal-binding site [ion binding]
233413000309	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413000310	Soluble P-type ATPase [General function prediction only]; Region: COG4087
233413000311	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
233413000312	NAD binding site [chemical binding]; other site
233413000313	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413000314	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413000315	ligand binding site [chemical binding]; other site
233413000316	flexible hinge region; other site
233413000317	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
233413000318	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
233413000319	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
233413000320	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
233413000321	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413000322	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
233413000323	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413000324	motif II; other site
233413000325	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
233413000326	PE family; Region: PE; pfam00934
233413000327	Rhomboid family; Region: Rhomboid; pfam01694
233413000328	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
233413000329	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
233413000330	active site
233413000331	catalytic triad [active]
233413000332	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413000333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413000334	NAD(P) binding site [chemical binding]; other site
233413000335	active site
233413000336	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
233413000337	dimer interface [polypeptide binding]; other site
233413000338	active site
233413000339	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
233413000340	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413000341	active site
233413000342	motif I; other site
233413000343	motif II; other site
233413000344	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
233413000345	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
233413000346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
233413000347	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
233413000348	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
233413000349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
233413000350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
233413000351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
233413000352	dimerization interface [polypeptide binding]; other site
233413000353	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
233413000354	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
233413000355	PYR/PP interface [polypeptide binding]; other site
233413000356	dimer interface [polypeptide binding]; other site
233413000357	TPP binding site [chemical binding]; other site
233413000358	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
233413000359	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
233413000360	TPP-binding site; other site
233413000361	dimer interface [polypeptide binding]; other site
233413000362	acyl-CoA synthetase; Validated; Region: PRK05852
233413000363	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413000364	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
233413000365	acyl-activating enzyme (AAE) consensus motif; other site
233413000366	acyl-activating enzyme (AAE) consensus motif; other site
233413000367	putative AMP binding site [chemical binding]; other site
233413000368	putative active site [active]
233413000369	putative CoA binding site [chemical binding]; other site
233413000370	elongation factor G; Reviewed; Region: PRK12740
233413000371	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
233413000372	G4 box; other site
233413000373	G5 box; other site
233413000374	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
233413000375	Elongation Factor G, domain II; Region: EFG_II; pfam14492
233413000376	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
233413000377	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
233413000378	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
233413000379	G1 box; other site
233413000380	GTP/Mg2+ binding site [chemical binding]; other site
233413000381	G2 box; other site
233413000382	Switch I region; other site
233413000383	G3 box; other site
233413000384	Switch II region; other site
233413000385	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
233413000386	PE family; Region: PE; pfam00934
233413000387	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
233413000388	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
233413000389	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
233413000390	protein binding site [polypeptide binding]; other site
233413000391	trehalose synthase; Region: treS_nterm; TIGR02456
233413000392	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
233413000393	active site
233413000394	catalytic site [active]
233413000395	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
233413000396	Predicted membrane protein [Function unknown]; Region: COG3619
233413000397	Predicted esterase [General function prediction only]; Region: COG0627
233413000398	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
233413000399	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
233413000400	putative active site [active]
233413000401	putative catalytic site [active]
233413000402	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413000403	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413000404	active site
233413000405	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413000406	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413000407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413000408	Coenzyme A binding pocket [chemical binding]; other site
233413000409	Mb0139-1, -, len: 128 aa. Pseudogene part1 of Rv0134/ephF
233413000410	Mb0139-2, -, len: 36 aa. Pseudogene part2 of Rv0134/ephF
233413000411	Mb0139-3, -, len: 80 aa. Pseudogene part3 of Rv0134/ephF
233413000412	Mb0139-4, -, len: 55 aa. Pseudogene part4 of Rv0134/ephF.
233413000413	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000414	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000415	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413000416	methionine sulfoxide reductase A; Provisional; Region: PRK14054
233413000417	SnoaL-like domain; Region: SnoaL_2; pfam12680
233413000418	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
233413000419	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413000420	NAD(P) binding site [chemical binding]; other site
233413000421	active site
233413000422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
233413000423	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
233413000424	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
233413000425	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
233413000426	minor groove reading motif; other site
233413000427	helix-hairpin-helix signature motif; other site
233413000428	active site
233413000429	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
233413000430	Cl- selectivity filter; other site
233413000431	Cl- binding residues [ion binding]; other site
233413000432	pore gating glutamate residue; other site
233413000433	dimer interface [polypeptide binding]; other site
233413000434	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000435	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000436	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413000437	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
233413000438	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
233413000439	NAD(P) binding site [chemical binding]; other site
233413000440	catalytic residues [active]
233413000441	short chain dehydrogenase; Provisional; Region: PRK07791
233413000442	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
233413000443	NAD binding site [chemical binding]; other site
233413000444	homodimer interface [polypeptide binding]; other site
233413000445	active site
233413000446	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
233413000447	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
233413000448	NAD(P) binding site [chemical binding]; other site
233413000449	PE family; Region: PE; pfam00934
233413000450	PE-PPE domain; Region: PE-PPE; pfam08237
233413000451	PE-PPE domain; Region: PE-PPE; pfam08237
233413000452	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
233413000453	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
233413000454	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
233413000455	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413000456	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
233413000457	FAD binding site [chemical binding]; other site
233413000458	substrate binding site [chemical binding]; other site
233413000459	catalytic base [active]
233413000460	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
233413000461	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
233413000462	ligand binding site [chemical binding]; other site
233413000463	homodimer interface [polypeptide binding]; other site
233413000464	NAD(P) binding site [chemical binding]; other site
233413000465	trimer interface B [polypeptide binding]; other site
233413000466	trimer interface A [polypeptide binding]; other site
233413000467	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
233413000468	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
233413000469	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
233413000470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000472	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
233413000473	PE family; Region: PE; pfam00934
233413000474	PE-PPE domain; Region: PE-PPE; pfam08237
233413000475	PE family; Region: PE; pfam00934
233413000476	PE-PPE domain; Region: PE-PPE; pfam08237
233413000477	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413000478	FAD binding domain; Region: FAD_binding_4; pfam01565
233413000479	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
233413000480	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
233413000481	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
233413000482	NAD(P) binding site [chemical binding]; other site
233413000483	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
233413000484	active site
233413000485	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
233413000486	putative hydrophobic ligand binding site [chemical binding]; other site
233413000487	Transcriptional regulators [Transcription]; Region: GntR; COG1802
233413000488	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
233413000489	DNA-binding site [nucleotide binding]; DNA binding site
233413000490	FCD domain; Region: FCD; pfam07729
233413000491	Mb0171c, -, len: 59 aa. Equivalent to 3' end of Rv0165c, len: 264 aa, from Mycobacterium tuberculosis strain H37Rv, (96.5% identity in 57 aa overlap). Possible transcriptional regulator, GntR family, showing some similarity to several e.g. NTRA_CHELE|P54988 nta operon transcriptional regulator (231 aa), FASTA scores: opt: 154, E(): 0.00058, (32.0% identity in 125 aa overlap); P46833|GNTR_BACLI GLUCONATE OPERON TRANSCRIPTIONAL REPRESSOR from Bacillus licheniformis (243 aa); GNTR_BACSU GLUCONATE OPERON REPRESSOR from Bacillus subtilis (243 aa). Also similar to Rv0043c from Mycobacterium tuberculosis. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH part. Mb0171c corresponds to the remnant COOH part of Rv0165c.;POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY)
233413000492	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
233413000493	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
233413000494	acyl-activating enzyme (AAE) consensus motif; other site
233413000495	putative AMP binding site [chemical binding]; other site
233413000496	putative active site [active]
233413000497	putative CoA binding site [chemical binding]; other site
233413000498	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
233413000499	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
233413000500	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413000501	mce related protein; Region: MCE; pfam02470
233413000502	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413000503	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
233413000504	mce related protein; Region: MCE; pfam02470
233413000505	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413000506	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413000507	mce related protein; Region: MCE; pfam02470
233413000508	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413000509	mce related protein; Region: MCE; pfam02470
233413000510	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413000511	mce related protein; Region: MCE; pfam02470
233413000512	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413000513	mce related protein; Region: MCE; pfam02470
233413000514	RDD family; Region: RDD; pfam06271
233413000515	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
233413000516	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
233413000517	Predicted membrane protein [Function unknown]; Region: COG1511
233413000518	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
233413000519	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
233413000520	Pirin-related protein [General function prediction only]; Region: COG1741
233413000521	Pirin; Region: Pirin; pfam02678
233413000522	RNA polymerase factor sigma-70; Validated; Region: PRK08241
233413000523	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413000524	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413000525	DNA binding residues [nucleotide binding]
233413000526	SnoaL-like domain; Region: SnoaL_2; pfam12680
233413000527	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
233413000528	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
233413000529	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413000530	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
233413000531	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
233413000532	Probable beta-xylosidase; Provisional; Region: PLN03080
233413000533	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
233413000534	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
233413000535	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
233413000536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413000537	S-adenosylmethionine binding site [chemical binding]; other site
233413000538	SPW repeat; Region: SPW; pfam03779
233413000539	SPW repeat; Region: SPW; pfam03779
233413000540	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
233413000541	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
233413000542	putative homodimer interface [polypeptide binding]; other site
233413000543	putative homotetramer interface [polypeptide binding]; other site
233413000544	putative allosteric switch controlling residues; other site
233413000545	putative metal binding site [ion binding]; other site
233413000546	putative homodimer-homodimer interface [polypeptide binding]; other site
233413000547	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
233413000548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413000549	putative substrate translocation pore; other site
233413000550	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
233413000551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
233413000552	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
233413000553	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
233413000554	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
233413000555	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413000556	Walker A/P-loop; other site
233413000557	ATP binding site [chemical binding]; other site
233413000558	Q-loop/lid; other site
233413000559	ABC transporter signature motif; other site
233413000560	Walker B; other site
233413000561	D-loop; other site
233413000562	H-loop/switch region; other site
233413000563	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
233413000564	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
233413000565	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413000566	Walker A/P-loop; other site
233413000567	ATP binding site [chemical binding]; other site
233413000568	Q-loop/lid; other site
233413000569	ABC transporter signature motif; other site
233413000570	Walker B; other site
233413000571	D-loop; other site
233413000572	H-loop/switch region; other site
233413000573	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413000574	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413000575	DNA binding residues [nucleotide binding]
233413000576	dimerization interface [polypeptide binding]; other site
233413000577	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000578	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000579	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
233413000580	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
233413000581	putative [Fe4-S4] binding site [ion binding]; other site
233413000582	putative molybdopterin cofactor binding site [chemical binding]; other site
233413000583	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
233413000584	putative molybdopterin cofactor binding site; other site
233413000585	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
233413000586	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
233413000587	active site
233413000588	Zn binding site [ion binding]; other site
233413000589	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413000590	MMPL family; Region: MMPL; cl14618
233413000591	MMPL family; Region: MMPL; cl14618
233413000592	Predicted integral membrane protein [Function unknown]; Region: COG0392
233413000593	Domain of unknown function DUF20; Region: UPF0118; pfam01594
233413000594	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
233413000595	MMPL family; Region: MMPL; cl14618
233413000596	MMPL family; Region: MMPL; cl14618
233413000597	LabA_like proteins; Region: LabA_like; cd06167
233413000598	putative metal binding site [ion binding]; other site
233413000599	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
233413000600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413000601	S-adenosylmethionine binding site [chemical binding]; other site
233413000602	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
233413000603	active site
233413000604	substrate-binding site [chemical binding]; other site
233413000605	metal-binding site [ion binding]
233413000606	GTP binding site [chemical binding]; other site
233413000607	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
233413000608	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
233413000609	active site
233413000610	(T/H)XGH motif; other site
233413000611	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
233413000612	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
233413000613	Radical SAM superfamily; Region: Radical_SAM; pfam04055
233413000614	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413000615	FeS/SAM binding site; other site
233413000616	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
233413000617	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
233413000618	acyl-activating enzyme (AAE) consensus motif; other site
233413000619	putative AMP binding site [chemical binding]; other site
233413000620	putative active site [active]
233413000621	putative CoA binding site [chemical binding]; other site
233413000622	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413000623	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413000624	active site
233413000625	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
233413000626	putative active site [active]
233413000627	putative catalytic site [active]
233413000628	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
233413000629	active site 2 [active]
233413000630	active site 1 [active]
233413000631	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413000632	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413000633	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
233413000634	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
233413000635	Moco binding site; other site
233413000636	metal coordination site [ion binding]; other site
233413000637	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413000638	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413000639	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413000640	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
233413000641	NAD(P) binding site [chemical binding]; other site
233413000642	catalytic residues [active]
233413000643	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413000644	S-adenosylmethionine binding site [chemical binding]; other site
233413000645	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
233413000646	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
233413000647	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
233413000648	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
233413000649	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
233413000650	putative active site [active]
233413000651	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
233413000652	active site
233413000653	substrate binding pocket [chemical binding]; other site
233413000654	homodimer interaction site [polypeptide binding]; other site
233413000655	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413000656	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413000657	active site
233413000658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000660	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
233413000661	active site
233413000662	diiron metal binding site [ion binding]; other site
233413000663	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
233413000664	NAD(P) binding site [chemical binding]; other site
233413000665	catalytic residues [active]
233413000666	Lipase maturation factor; Region: LMF1; pfam06762
233413000667	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
233413000668	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
233413000669	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
233413000670	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000672	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413000673	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
233413000674	MaoC like domain; Region: MaoC_dehydratas; pfam01575
233413000675	active site 2 [active]
233413000676	active site 1 [active]
233413000677	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
233413000678	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413000679	NAD(P) binding site [chemical binding]; other site
233413000680	active site
233413000681	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
233413000682	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
233413000683	dimer interface [polypeptide binding]; other site
233413000684	active site
233413000685	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
233413000686	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
233413000687	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
233413000688	FAD binding site [chemical binding]; other site
233413000689	substrate binding site [chemical binding]; other site
233413000690	catalytic residues [active]
233413000691	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
233413000692	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
233413000693	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
233413000694	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413000695	catalytic loop [active]
233413000696	iron binding site [ion binding]; other site
233413000697	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
233413000698	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
233413000699	L-aspartate oxidase; Provisional; Region: PRK06175
233413000700	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
233413000701	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
233413000702	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
233413000703	putative dimer interface [polypeptide binding]; other site
233413000704	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
233413000705	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413000706	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
233413000707	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
233413000708	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
233413000709	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
233413000710	Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase [Coenzyme metabolism]; Region: CobU; COG2087
233413000711	cobyric acid synthase; Provisional; Region: PRK00784
233413000712	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413000713	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
233413000714	catalytic triad [active]
233413000715	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000716	PPE family; Region: PPE; pfam00823
233413000717	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
233413000718	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
233413000719	putative active site [active]
233413000720	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
233413000721	putative active site [active]
233413000722	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
233413000723	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
233413000724	active site
233413000725	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
233413000726	DNA binding site [nucleotide binding]
233413000727	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
233413000728	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
233413000729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413000730	Coenzyme A binding pocket [chemical binding]; other site
233413000731	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
233413000732	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
233413000733	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
233413000734	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
233413000735	intersubunit interface [polypeptide binding]; other site
233413000736	5-oxoprolinase; Region: PLN02666
233413000737	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
233413000738	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
233413000739	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
233413000740	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
233413000741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413000742	putative substrate translocation pore; other site
233413000743	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
233413000744	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
233413000745	nucleotide binding site [chemical binding]; other site
233413000746	acyl-CoA synthetase; Validated; Region: PRK07788
233413000747	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413000748	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413000749	acyl-activating enzyme (AAE) consensus motif; other site
233413000750	acyl-activating enzyme (AAE) consensus motif; other site
233413000751	AMP binding site [chemical binding]; other site
233413000752	active site
233413000753	active site
233413000754	AMP binding site [chemical binding]; other site
233413000755	CoA binding site [chemical binding]; other site
233413000756	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413000757	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413000758	active site
233413000759	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
233413000760	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413000761	FAD binding site [chemical binding]; other site
233413000762	substrate binding site [chemical binding]; other site
233413000763	catalytic base [active]
233413000764	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413000765	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000766	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000767	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
233413000768	Zn binding site [ion binding]; other site
233413000769	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000770	Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382
233413000771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
233413000772	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413000773	putative active site [active]
233413000774	Mb0284c, PE_PGRS3b, len: 80 aa. Equivalent to 3' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 79 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b.;PE-PGRS FAMILY PROTEIN [SECOND PART]
233413000775	PE family; Region: PE; pfam00934
233413000776	PE family; Region: PE; pfam00934
233413000777	PE family; Region: PE; pfam00934
233413000778	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000779	PPE family; Region: PPE; pfam00823
233413000780	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413000781	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
233413000782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
233413000783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413000784	Walker A motif; other site
233413000785	ATP binding site [chemical binding]; other site
233413000786	Walker B motif; other site
233413000787	arginine finger; other site
233413000788	Protein of unknown function (DUF690); Region: DUF690; pfam05108
233413000789	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
233413000790	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413000791	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
233413000792	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413000793	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413000794	PE family; Region: PE; pfam00934
233413000795	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000796	PPE family; Region: PPE; pfam00823
233413000797	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
233413000798	EspG family; Region: ESX-1_EspG; pfam14011
233413000799	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
233413000800	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
233413000801	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
233413000802	active site
233413000803	catalytic residues [active]
233413000804	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
233413000805	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413000806	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
233413000807	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
233413000808	FtsJ-like methyltransferase; Region: FtsJ; cl17430
233413000809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413000810	S-adenosylmethionine binding site [chemical binding]; other site
233413000811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424
233413000812	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
233413000813	Sulfatase; Region: Sulfatase; pfam00884
233413000814	PE family; Region: PE; pfam00934
233413000815	hypothetical protein; Region: PHA01748
233413000816	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
233413000817	putative active site [active]
233413000818	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000819	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000820	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
233413000821	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
233413000822	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
233413000823	putative NAD(P) binding site [chemical binding]; other site
233413000824	active site
233413000825	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000826	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000827	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000828	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000829	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000830	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000831	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000832	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000833	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000834	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000835	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000836	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000837	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000838	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000839	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000840	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000841	PPE family; Region: PPE; pfam00823
233413000842	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000843	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000844	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000845	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000846	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000847	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000848	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000849	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000850	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000851	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000852	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000853	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000854	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000855	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000856	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000857	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000858	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000859	BDLF3; Provisional; Region: PHA03255
233413000860	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000861	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000862	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000863	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000864	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000865	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000866	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
233413000867	FMN binding site [chemical binding]; other site
233413000868	dimer interface [polypeptide binding]; other site
233413000869	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
233413000870	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
233413000871	active site
233413000872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
233413000873	SnoaL-like domain; Region: SnoaL_4; pfam13577
233413000874	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
233413000875	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
233413000876	nucleotide binding site [chemical binding]; other site
233413000877	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
233413000878	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
233413000879	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
233413000880	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
233413000881	active site
233413000882	catalytic residues [active]
233413000883	Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
233413000884	Muconolactone delta-isomerase; Region: MIase; cl01992
233413000885	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
233413000886	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
233413000887	putative active site [active]
233413000888	catalytic site [active]
233413000889	putative metal binding site [ion binding]; other site
233413000890	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
233413000891	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
233413000892	putative substrate binding pocket [chemical binding]; other site
233413000893	AC domain interface; other site
233413000894	catalytic triad [active]
233413000895	AB domain interface; other site
233413000896	interchain disulfide; other site
233413000897	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
233413000898	trimer interface [polypeptide binding]; other site
233413000899	active site
233413000900	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
233413000901	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
233413000902	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
233413000903	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
233413000904	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
233413000905	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413000906	dimerization interface [polypeptide binding]; other site
233413000907	putative DNA binding site [nucleotide binding]; other site
233413000908	putative Zn2+ binding site [ion binding]; other site
233413000909	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
233413000910	active site residue [active]
233413000911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413000912	S-adenosylmethionine binding site [chemical binding]; other site
233413000913	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413000914	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
233413000915	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000916	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
233413000917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413000918	S-adenosylmethionine binding site [chemical binding]; other site
233413000919	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413000920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413000921	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
233413000922	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413000923	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
233413000924	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
233413000925	SnoaL-like domain; Region: SnoaL_2; pfam12680
233413000926	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
233413000927	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
233413000928	substrate binding site; other site
233413000929	tetramer interface; other site
233413000930	PE family; Region: PE; pfam00934
233413000931	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413000932	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413000933	active site
233413000934	aminotransferase AlaT; Validated; Region: PRK09265
233413000935	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413000936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413000937	homodimer interface [polypeptide binding]; other site
233413000938	catalytic residue [active]
233413000939	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
233413000940	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
233413000941	Cysteine-rich domain; Region: CCG; pfam02754
233413000942	Cysteine-rich domain; Region: CCG; pfam02754
233413000943	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
233413000944	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413000945	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413000946	DNA binding residues [nucleotide binding]
233413000947	dimerization interface [polypeptide binding]; other site
233413000948	EBNA-3A; Provisional; Region: PHA03379
233413000949	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
233413000950	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
233413000951	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
233413000952	G3 box; other site
233413000953	Switch II region; other site
233413000954	GTP/Mg2+ binding site [chemical binding]; other site
233413000955	G4 box; other site
233413000956	G5 box; other site
233413000957	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
233413000958	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
233413000959	G1 box; other site
233413000960	GTP/Mg2+ binding site [chemical binding]; other site
233413000961	G2 box; other site
233413000962	Switch I region; other site
233413000963	G3 box; other site
233413000964	Switch II region; other site
233413000965	G4 box; other site
233413000966	G5 box; other site
233413000967	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
233413000968	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
233413000969	TIGR04255 family protein; Region: sporadTIGR04255
233413000970	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
233413000971	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
233413000972	nucleotide binding site [chemical binding]; other site
233413000973	NEF interaction site [polypeptide binding]; other site
233413000974	SBD interface [polypeptide binding]; other site
233413000975	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
233413000976	dimer interface [polypeptide binding]; other site
233413000977	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
233413000978	chaperone protein DnaJ; Provisional; Region: PRK14279
233413000979	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
233413000980	HSP70 interaction site [polypeptide binding]; other site
233413000981	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
233413000982	Zn binding sites [ion binding]; other site
233413000983	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
233413000984	dimer interface [polypeptide binding]; other site
233413000985	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
233413000986	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
233413000987	DNA binding residues [nucleotide binding]
233413000988	putative dimer interface [polypeptide binding]; other site
233413000989	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000990	PPE family; Region: PPE; pfam00823
233413000991	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000992	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413000993	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000994	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000995	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000996	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000997	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000998	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413000999	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001000	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001001	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001002	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001003	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001004	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001005	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001006	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001007	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001008	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001009	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001010	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001011	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001012	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001013	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001014	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001015	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001016	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001017	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001018	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001019	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001020	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001021	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001022	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001023	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001024	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001025	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001026	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001027	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001028	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001029	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001030	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001031	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001032	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
233413001033	CoenzymeA binding site [chemical binding]; other site
233413001034	subunit interaction site [polypeptide binding]; other site
233413001035	PHB binding site; other site
233413001036	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
233413001037	GDP-binding site [chemical binding]; other site
233413001038	ACT binding site; other site
233413001039	IMP binding site; other site
233413001040	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
233413001041	Peptidase family M50; Region: Peptidase_M50; pfam02163
233413001042	active site
233413001043	putative substrate binding region [chemical binding]; other site
233413001044	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
233413001045	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
233413001046	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
233413001047	MgtE intracellular N domain; Region: MgtE_N; pfam03448
233413001048	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
233413001049	Divalent cation transporter; Region: MgtE; pfam01769
233413001050	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
233413001051	active site
233413001052	intersubunit interface [polypeptide binding]; other site
233413001053	zinc binding site [ion binding]; other site
233413001054	Na+ binding site [ion binding]; other site
233413001055	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
233413001056	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
233413001057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
233413001058	AAA domain; Region: AAA_33; pfam13671
233413001059	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
233413001060	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
233413001061	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
233413001062	metal ion-dependent adhesion site (MIDAS); other site
233413001063	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
233413001064	putative hydrophobic ligand binding site [chemical binding]; other site
233413001065	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
233413001066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413001067	Walker A motif; other site
233413001068	ATP binding site [chemical binding]; other site
233413001069	Walker B motif; other site
233413001070	arginine finger; other site
233413001071	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
233413001072	Ligand binding site; other site
233413001073	metal-binding site
233413001074	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
233413001075	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
233413001076	XdhC Rossmann domain; Region: XdhC_C; pfam13478
233413001077	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
233413001078	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
233413001079	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
233413001080	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
233413001081	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413001082	catalytic loop [active]
233413001083	iron binding site [ion binding]; other site
233413001084	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
233413001085	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
233413001086	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
233413001087	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
233413001088	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
233413001089	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
233413001090	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
233413001091	XdhC Rossmann domain; Region: XdhC_C; pfam13478
233413001092	Transcriptional regulator [Transcription]; Region: LysR; COG0583
233413001093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
233413001094	LysR substrate binding domain; Region: LysR_substrate; pfam03466
233413001095	dimerization interface [polypeptide binding]; other site
233413001096	Uncharacterized conserved protein [Function unknown]; Region: COG3360
233413001097	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
233413001098	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
233413001099	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413001100	active site
233413001101	Proline-rich; Region: Pro-rich; pfam15240
233413001102	Clp amino terminal domain; Region: Clp_N; pfam02861
233413001103	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
233413001104	Clp amino terminal domain; Region: Clp_N; pfam02861
233413001105	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413001106	Walker A motif; other site
233413001107	ATP binding site [chemical binding]; other site
233413001108	Walker B motif; other site
233413001109	arginine finger; other site
233413001110	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
233413001111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413001112	Walker A motif; other site
233413001113	ATP binding site [chemical binding]; other site
233413001114	Walker B motif; other site
233413001115	arginine finger; other site
233413001116	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
233413001117	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
233413001118	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
233413001119	heme-binding site [chemical binding]; other site
233413001120	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
233413001121	FAD binding pocket [chemical binding]; other site
233413001122	FAD binding motif [chemical binding]; other site
233413001123	phosphate binding motif [ion binding]; other site
233413001124	beta-alpha-beta structure motif; other site
233413001125	NAD binding pocket [chemical binding]; other site
233413001126	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413001127	cyclase homology domain; Region: CHD; cd07302
233413001128	nucleotidyl binding site; other site
233413001129	metal binding site [ion binding]; metal-binding site
233413001130	dimer interface [polypeptide binding]; other site
233413001131	Predicted ATPase [General function prediction only]; Region: COG3903
233413001132	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413001133	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413001134	DNA binding residues [nucleotide binding]
233413001135	dimerization interface [polypeptide binding]; other site
233413001136	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001137	PPE family; Region: PPE; pfam00823
233413001138	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027
233413001139	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
233413001140	ATP-grasp domain; Region: ATP-grasp_4; cl17255
233413001141	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
233413001142	active site residue [active]
233413001143	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
233413001144	homodimer interface [polypeptide binding]; other site
233413001145	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
233413001146	substrate-cofactor binding pocket; other site
233413001147	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413001148	catalytic residue [active]
233413001149	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
233413001150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413001151	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413001152	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413001153	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413001154	active site
233413001155	PLD-like domain; Region: PLDc_2; pfam13091
233413001156	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413001157	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
233413001158	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413001159	FAD binding site [chemical binding]; other site
233413001160	substrate binding pocket [chemical binding]; other site
233413001161	catalytic base [active]
233413001162	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
233413001163	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413001164	MMPL family; Region: MMPL; pfam03176
233413001165	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413001166	MMPL family; Region: MMPL; pfam03176
233413001167	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
233413001168	acyl-CoA synthetase; Validated; Region: PRK05850
233413001169	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413001170	acyl-activating enzyme (AAE) consensus motif; other site
233413001171	active site
233413001172	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413001173	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413001174	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413001175	active site
233413001176	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413001177	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
233413001178	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413001179	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413001180	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413001181	Thioesterase; Region: PKS_TE; smart00824
233413001182	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
233413001183	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413001184	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413001185	phosphate acetyltransferase; Reviewed; Region: PRK05632
233413001186	DRTGG domain; Region: DRTGG; pfam07085
233413001187	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
233413001188	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
233413001189	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413001190	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413001191	active site
233413001192	ATP binding site [chemical binding]; other site
233413001193	substrate binding site [chemical binding]; other site
233413001194	activation loop (A-loop); other site
233413001195	Tetratricopeptide repeat; Region: TPR_16; pfam13432
233413001196	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
233413001197	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
233413001198	substrate binding pocket [chemical binding]; other site
233413001199	membrane-bound complex binding site; other site
233413001200	hinge residues; other site
233413001201	NUDIX domain; Region: NUDIX; pfam00293
233413001202	nudix motif; other site
233413001203	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
233413001204	thiamine phosphate binding site [chemical binding]; other site
233413001205	active site
233413001206	pyrophosphate binding site [ion binding]; other site
233413001207	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
233413001208	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
233413001209	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
233413001210	thiS-thiF/thiG interaction site; other site
233413001211	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
233413001212	ThiS interaction site; other site
233413001213	putative active site [active]
233413001214	tetramer interface [polypeptide binding]; other site
233413001215	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
233413001216	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
233413001217	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
233413001218	PA/protease or protease-like domain interface [polypeptide binding]; other site
233413001219	active site
233413001220	metal binding site [ion binding]; metal-binding site
233413001221	Predicted metalloprotease [General function prediction only]; Region: COG2321
233413001222	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
233413001223	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
233413001224	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
233413001225	dimer interface [polypeptide binding]; other site
233413001226	substrate binding site [chemical binding]; other site
233413001227	ATP binding site [chemical binding]; other site
233413001228	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
233413001229	ThiC-associated domain; Region: ThiC-associated; pfam13667
233413001230	ThiC family; Region: ThiC; pfam01964
233413001231	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
233413001232	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413001233	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413001234	motif II; other site
233413001235	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
233413001236	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
233413001237	putative catalytic site [active]
233413001238	putative phosphate binding site [ion binding]; other site
233413001239	active site
233413001240	metal binding site A [ion binding]; metal-binding site
233413001241	DNA binding site [nucleotide binding]
233413001242	putative AP binding site [nucleotide binding]; other site
233413001243	putative metal binding site B [ion binding]; other site
233413001244	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
233413001245	active site
233413001246	catalytic residues [active]
233413001247	metal binding site [ion binding]; metal-binding site
233413001248	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
233413001249	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
233413001250	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
233413001251	E-class dimer interface [polypeptide binding]; other site
233413001252	P-class dimer interface [polypeptide binding]; other site
233413001253	active site
233413001254	Cu2+ binding site [ion binding]; other site
233413001255	Zn2+ binding site [ion binding]; other site
233413001256	carboxylate-amine ligase; Provisional; Region: PRK13517
233413001257	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
233413001258	Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073
233413001259	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
233413001260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413001261	Walker A motif; other site
233413001262	ATP binding site [chemical binding]; other site
233413001263	Walker B motif; other site
233413001264	arginine finger; other site
233413001265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413001266	Walker A motif; other site
233413001267	ATP binding site [chemical binding]; other site
233413001268	Walker B motif; other site
233413001269	arginine finger; other site
233413001270	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
233413001271	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
233413001272	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
233413001273	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
233413001274	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
233413001275	dimer interface [polypeptide binding]; other site
233413001276	putative functional site; other site
233413001277	putative MPT binding site; other site
233413001278	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
233413001279	short chain dehydrogenase; Provisional; Region: PRK12828
233413001280	putative NAD(P) binding site [chemical binding]; other site
233413001281	active site
233413001282	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
233413001283	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
233413001284	ring oligomerisation interface [polypeptide binding]; other site
233413001285	ATP/Mg binding site [chemical binding]; other site
233413001286	stacking interactions; other site
233413001287	hinge regions; other site
233413001288	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001289	PPE family; Region: PPE; pfam00823
233413001290	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001291	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413001292	Protein of unknown function (DUF664); Region: DUF664; pfam04978
233413001293	putative anti-sigmaE protein; Provisional; Region: PRK13920
233413001294	Anti-sigma-K factor rskA; Region: RskA; pfam10099
233413001295	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
233413001296	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413001297	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413001298	DNA binding residues [nucleotide binding]
233413001299	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
233413001300	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001302	S-adenosylmethionine binding site [chemical binding]; other site
233413001303	Uncharacterized conserved protein [Function unknown]; Region: COG3496
233413001304	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
233413001305	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413001306	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
233413001307	dimer interface [polypeptide binding]; other site
233413001308	Transport protein; Region: actII; TIGR00833
233413001309	MMPL family; Region: MMPL; pfam03176
233413001310	MMPL family; Region: MMPL; pfam03176
233413001311	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
233413001312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413001313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413001314	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413001315	PPE family; Region: PPE; pfam00823
233413001316	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
233413001317	enoyl-CoA hydratase; Provisional; Region: PRK12478
233413001318	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413001319	substrate binding site [chemical binding]; other site
233413001320	oxyanion hole (OAH) forming residues; other site
233413001321	trimer interface [polypeptide binding]; other site
233413001322	PemK-like protein; Region: PemK; pfam02452
233413001323	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
233413001324	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
233413001325	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
233413001326	NAD(P) binding site [chemical binding]; other site
233413001327	catalytic residues [active]
233413001328	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
233413001329	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
233413001330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413001331	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413001332	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
233413001333	Uncharacterized conserved protein [Function unknown]; Region: COG2128
233413001334	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
233413001335	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
233413001336	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413001337	non-specific DNA binding site [nucleotide binding]; other site
233413001338	salt bridge; other site
233413001339	sequence-specific DNA binding site [nucleotide binding]; other site
233413001340	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
233413001341	Domain of unknown function (DUF955); Region: DUF955; pfam06114
233413001342	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
233413001343	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
233413001344	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
233413001345	active site
233413001346	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
233413001347	active site 2 [active]
233413001348	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556
233413001349	oligomerization interface [polypeptide binding]; other site
233413001350	active site
233413001351	metal binding site [ion binding]; metal-binding site
233413001352	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
233413001353	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
233413001354	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
233413001355	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001356	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413001357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001358	S-adenosylmethionine binding site [chemical binding]; other site
233413001359	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413001361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001362	S-adenosylmethionine binding site [chemical binding]; other site
233413001363	UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
233413001364	UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
233413001365	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413001366	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413001367	Predicted membrane protein [Function unknown]; Region: COG2733
233413001368	Protein of unknown function (DUF445); Region: DUF445; pfam04286
233413001369	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
233413001370	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413001371	non-specific DNA binding site [nucleotide binding]; other site
233413001372	salt bridge; other site
233413001373	sequence-specific DNA binding site [nucleotide binding]; other site
233413001374	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
233413001375	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
233413001376	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
233413001377	intersubunit interface [polypeptide binding]; other site
233413001378	active site
233413001379	catalytic residue [active]
233413001380	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
233413001381	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
233413001382	putative active site [active]
233413001383	catalytic triad [active]
233413001384	putative dimer interface [polypeptide binding]; other site
233413001385	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
233413001386	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
233413001387	FAD binding domain; Region: FAD_binding_4; pfam01565
233413001388	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
233413001389	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
233413001390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
233413001391	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
233413001392	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
233413001393	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
233413001394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413001395	NAD(P) binding site [chemical binding]; other site
233413001396	active site
233413001397	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
233413001398	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
233413001399	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
233413001400	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
233413001401	putative ADP-binding pocket [chemical binding]; other site
233413001402	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
233413001403	L-lysine exporter; Region: 2a75; TIGR00948
233413001404	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413001405	catalytic core [active]
233413001406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413001407	dimer interface [polypeptide binding]; other site
233413001408	phosphorylation site [posttranslational modification]
233413001409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413001410	ATP binding site [chemical binding]; other site
233413001411	Mg2+ binding site [ion binding]; other site
233413001412	G-X-G motif; other site
233413001413	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413001414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413001415	active site
233413001416	phosphorylation site [posttranslational modification]
233413001417	intermolecular recognition site; other site
233413001418	dimerization interface [polypeptide binding]; other site
233413001419	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413001420	DNA binding site [nucleotide binding]
233413001421	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
233413001422	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413001423	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
233413001424	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
233413001425	Transcriptional regulators [Transcription]; Region: FadR; COG2186
233413001426	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
233413001427	DNA-binding site [nucleotide binding]; DNA binding site
233413001428	FCD domain; Region: FCD; pfam07729
233413001429	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
233413001430	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
233413001431	Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667
233413001432	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
233413001433	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
233413001434	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
233413001435	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
233413001436	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
233413001437	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
233413001438	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
233413001439	DNA binding domain, excisionase family; Region: excise; TIGR01764
233413001440	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413001441	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
233413001442	putative NAD(P) binding site [chemical binding]; other site
233413001443	active site
233413001444	putative substrate binding site [chemical binding]; other site
233413001445	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
233413001446	putative acyl-acceptor binding pocket; other site
233413001447	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413001449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001450	S-adenosylmethionine binding site [chemical binding]; other site
233413001451	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
233413001452	active site
233413001453	catalytic site [active]
233413001454	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
233413001455	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
233413001456	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
233413001457	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413001458	MMPL family; Region: MMPL; pfam03176
233413001459	MMPL family; Region: MMPL; pfam03176
233413001460	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
233413001461	glutamyl-tRNA reductase; Region: hemA; TIGR01035
233413001462	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
233413001463	tRNA; other site
233413001464	putative tRNA binding site [nucleotide binding]; other site
233413001465	putative NADP binding site [chemical binding]; other site
233413001466	Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
233413001467	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
233413001468	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
233413001469	domain interfaces; other site
233413001470	active site
233413001471	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
233413001472	active site
233413001473	homodimer interface [polypeptide binding]; other site
233413001474	SAM binding site [chemical binding]; other site
233413001475	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
233413001476	active site
233413001477	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
233413001478	dimer interface [polypeptide binding]; other site
233413001479	active site
233413001480	Schiff base residues; other site
233413001481	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413001482	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413001483	active site
233413001484	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
233413001485	anti sigma factor interaction site; other site
233413001486	regulatory phosphorylation site [posttranslational modification]; other site
233413001487	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
233413001488	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
233413001489	active site
233413001490	catalytic triad [active]
233413001491	oxyanion hole [active]
233413001492	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
233413001493	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413001494	S-formylglutathione hydrolase; Region: PLN02442
233413001495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001496	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413001497	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
233413001498	Domain of unknown function (DUF385); Region: DUF385; pfam04075
233413001499	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
233413001500	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
233413001501	inhibitor-cofactor binding pocket; inhibition site
233413001502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413001503	catalytic residue [active]
233413001504	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
233413001505	catalytic core [active]
233413001506	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
233413001507	catalytic residues [active]
233413001508	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
233413001509	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
233413001510	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
233413001511	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
233413001512	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
233413001513	P-loop; other site
233413001514	Magnesium ion binding site [ion binding]; other site
233413001515	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
233413001516	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
233413001517	PE family; Region: PE; pfam00934
233413001518	Mb0546, PE_PGRS6b, len: 75 aa. Equivalent to 3' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 75 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b.;PE-PGRS FAMILY PROTEIN [SECOND PART]
233413001519	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
233413001520	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
233413001521	dimer interface [polypeptide binding]; other site
233413001522	active site
233413001523	CoA binding pocket [chemical binding]; other site
233413001524	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
233413001525	putative active site [active]
233413001526	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
233413001527	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
233413001528	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413001529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413001530	NAD(P) binding site [chemical binding]; other site
233413001531	active site
233413001532	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
233413001533	Ligand binding site; other site
233413001534	Putative Catalytic site; other site
233413001535	DXD motif; other site
233413001536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222
233413001537	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
233413001538	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413001539	acyl-activating enzyme (AAE) consensus motif; other site
233413001540	AMP binding site [chemical binding]; other site
233413001541	active site
233413001542	CoA binding site [chemical binding]; other site
233413001543	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
233413001544	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
233413001545	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
233413001546	active site
233413001547	short chain dehydrogenase; Provisional; Region: PRK05866
233413001548	classical (c) SDRs; Region: SDR_c; cd05233
233413001549	NAD(P) binding site [chemical binding]; other site
233413001550	active site
233413001551	Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447
233413001552	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413001553	substrate binding site [chemical binding]; other site
233413001554	oxyanion hole (OAH) forming residues; other site
233413001555	trimer interface [polypeptide binding]; other site
233413001556	Mb0563c, -, len: 45 aa. Similar to 3' end of Rv0549c, len: 137 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 45 aa overlap). Conserved hypothetical protein, similar to Rv0960, Rv0065, and Rv1720c from Mycobacterium tuberculosis. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts, Mb0563c and Mb0564c.;CONSERVED HYPOTHETICAL PROTEIN [SECOND PART]
233413001557	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
233413001558	putative active site [active]
233413001559	homotetrameric interface [polypeptide binding]; other site
233413001560	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302
233413001561	acyl-CoA synthetase; Validated; Region: PRK06188
233413001562	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
233413001563	putative active site [active]
233413001564	putative CoA binding site [chemical binding]; other site
233413001565	putative AMP binding site [chemical binding]; other site
233413001566	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
233413001567	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
233413001568	active site
233413001569	O-succinylbenzoate synthase; Provisional; Region: PRK02901
233413001570	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
233413001571	active site
233413001572	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413001573	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413001574	TAP-like protein; Region: Abhydrolase_4; pfam08386
233413001575	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
233413001576	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
233413001577	dimer interface [polypeptide binding]; other site
233413001578	tetramer interface [polypeptide binding]; other site
233413001579	PYR/PP interface [polypeptide binding]; other site
233413001580	TPP binding site [chemical binding]; other site
233413001581	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
233413001582	TPP-binding site; other site
233413001583	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
233413001584	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
233413001585	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
233413001586	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
233413001587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001588	S-adenosylmethionine binding site [chemical binding]; other site
233413001589	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413001590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001591	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413001592	S-adenosylmethionine binding site [chemical binding]; other site
233413001593	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
233413001594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413001595	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413001596	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
233413001597	substrate binding pocket [chemical binding]; other site
233413001598	chain length determination region; other site
233413001599	substrate-Mg2+ binding site; other site
233413001600	catalytic residues [active]
233413001601	aspartate-rich region 1; other site
233413001602	active site lid residues [active]
233413001603	aspartate-rich region 2; other site
233413001604	heat shock protein HtpX; Provisional; Region: PRK03072
233413001605	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
233413001606	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
233413001607	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
233413001608	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413001609	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
233413001610	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
233413001611	O-methyltransferase; Region: Methyltransf_2; pfam00891
233413001612	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413001613	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
233413001614	ATP cone domain; Region: ATP-cone; pfam03477
233413001615	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
233413001616	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
233413001617	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
233413001618	active site
233413001619	dimer interface [polypeptide binding]; other site
233413001620	effector binding site; other site
233413001621	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413001622	active site
233413001623	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413001624	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
233413001625	nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484
233413001626	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
233413001627	active site
233413001628	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
233413001629	putative active site [active]
233413001630	putative metal binding site [ion binding]; other site
233413001631	hypothetical protein; Provisional; Region: PRK07588
233413001632	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
233413001633	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413001634	dimerization interface [polypeptide binding]; other site
233413001635	putative DNA binding site [nucleotide binding]; other site
233413001636	putative Zn2+ binding site [ion binding]; other site
233413001637	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
233413001638	putative hydrophobic ligand binding site [chemical binding]; other site
233413001639	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413001640	TIGR03086 family protein; Region: TIGR03086
233413001641	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
233413001642	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
233413001643	PE family; Region: PE; pfam00934
233413001644	Mut7-C ubiquitin; Region: Ub-Mut7C; pfam14451
233413001645	Mut7-C RNAse domain; Region: Mut7-C; pfam01927
233413001646	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413001647	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413001648	putative active site [active]
233413001649	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
233413001650	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
233413001651	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
233413001652	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
233413001653	Transcriptional regulators [Transcription]; Region: FadR; COG2186
233413001654	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
233413001655	DNA-binding site [nucleotide binding]; DNA binding site
233413001656	FCD domain; Region: FCD; pfam07729
233413001657	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
233413001658	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
233413001659	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413001660	mce related protein; Region: MCE; pfam02470
233413001661	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413001662	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
233413001663	mce related protein; Region: MCE; pfam02470
233413001664	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413001665	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413001666	mce related protein; Region: MCE; pfam02470
233413001667	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413001668	mce related protein; Region: MCE; pfam02470
233413001669	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413001670	Mb0608, mce2Db, len: 47 aa. Equivalent to 3' end of Rv0592, len: 508 aa, from Mycobacterium tuberculosis strain H37Rv, (95.7% identity in 47 aa overlap). mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly similar to others e.g. NP_302659.1|NC_002677  secreted protein from Mycobacterium leprae (531 aa); CAC12795.1|AL445327  secreted protein from Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich C-terminus and may contain N-terminal signal or anchor sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits mce2D into 2 parts, mce2Da and mce2Db.;MCE-FAMILY PROTEIN MCE2DB [SECOND PART]
233413001671	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413001672	mce related protein; Region: MCE; pfam02470
233413001673	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413001674	mce related protein; Region: MCE; pfam02470
233413001675	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
233413001676	oligomeric interface; other site
233413001677	putative active site [active]
233413001678	homodimer interface [polypeptide binding]; other site
233413001679	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
233413001680	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
233413001681	AAA domain; Region: AAA_14; pfam13173
233413001682	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
233413001683	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413001684	putative active site [active]
233413001685	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
233413001686	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413001687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413001688	ATP binding site [chemical binding]; other site
233413001689	Mg2+ binding site [ion binding]; other site
233413001690	G-X-G motif; other site
233413001691	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413001692	dimerization interface [polypeptide binding]; other site
233413001693	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413001694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413001695	active site
233413001696	phosphorylation site [posttranslational modification]
233413001697	intermolecular recognition site; other site
233413001698	dimerization interface [polypeptide binding]; other site
233413001699	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413001700	DNA binding site [nucleotide binding]
233413001701	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
233413001702	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
233413001703	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
233413001704	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
233413001705	catalytic residues [active]
233413001706	catalytic nucleophile [active]
233413001707	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
233413001708	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
233413001709	Probable transposase; Region: OrfB_IS605; pfam01385
233413001710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
233413001711	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
233413001712	putative active site [active]
233413001713	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
233413001714	SEC-C motif; Region: SEC-C; pfam02810
233413001715	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
233413001716	putative active site [active]
233413001717	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
233413001718	dimer interface [polypeptide binding]; other site
233413001719	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
233413001720	active site
233413001721	galactokinase; Provisional; Region: PRK00555
233413001722	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
233413001723	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
233413001724	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
233413001725	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413001726	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
233413001727	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
233413001728	putative active site [active]
233413001729	Uncharacterized conserved protein [Function unknown]; Region: COG0398
233413001730	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
233413001731	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
233413001732	oligomeric interface; other site
233413001733	putative active site [active]
233413001734	homodimer interface [polypeptide binding]; other site
233413001735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
233413001736	FIST N domain; Region: FIST; pfam08495
233413001737	FIST C domain; Region: FIST_C; pfam10442
233413001738	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
233413001739	AAA domain; Region: AAA_30; pfam13604
233413001740	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
233413001741	Mb0646c, recBb, len: 234 aa. Equivalent to 3' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 234 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V, beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICase, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb.;PROBABLE EXONUCLEASE V (BETA CHAIN) RECBB [SECOND PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE)
233413001742	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
233413001743	Part of AAA domain; Region: AAA_19; pfam13245
233413001744	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
233413001745	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
233413001746	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
233413001747	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
233413001748	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413001749	substrate binding site [chemical binding]; other site
233413001750	oxyanion hole (OAH) forming residues; other site
233413001751	trimer interface [polypeptide binding]; other site
233413001752	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
233413001753	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
233413001754	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
233413001755	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
233413001756	active site
233413001757	catalytic site [active]
233413001758	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
233413001759	active site
233413001760	catalytic site [active]
233413001761	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
233413001762	active site
233413001763	catalytic site [active]
233413001764	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
233413001765	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
233413001766	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
233413001767	putative homodimer interface [polypeptide binding]; other site
233413001768	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
233413001769	heterodimer interface [polypeptide binding]; other site
233413001770	homodimer interface [polypeptide binding]; other site
233413001771	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
233413001772	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
233413001773	23S rRNA interface [nucleotide binding]; other site
233413001774	L7/L12 interface [polypeptide binding]; other site
233413001775	putative thiostrepton binding site; other site
233413001776	L25 interface [polypeptide binding]; other site
233413001777	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
233413001778	mRNA/rRNA interface [nucleotide binding]; other site
233413001779	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001781	S-adenosylmethionine binding site [chemical binding]; other site
233413001782	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413001784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001785	S-adenosylmethionine binding site [chemical binding]; other site
233413001786	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413001788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001789	S-adenosylmethionine binding site [chemical binding]; other site
233413001790	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413001791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413001792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413001793	S-adenosylmethionine binding site [chemical binding]; other site
233413001794	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413001795	TAP-like protein; Region: Abhydrolase_4; pfam08386
233413001796	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
233413001797	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
233413001798	active site
233413001799	ATP binding site [chemical binding]; other site
233413001800	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
233413001801	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
233413001802	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
233413001803	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
233413001804	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
233413001805	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
233413001806	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
233413001807	nucleotide binding site [chemical binding]; other site
233413001808	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
233413001809	23S rRNA interface [nucleotide binding]; other site
233413001810	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
233413001811	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
233413001812	core dimer interface [polypeptide binding]; other site
233413001813	peripheral dimer interface [polypeptide binding]; other site
233413001814	L10 interface [polypeptide binding]; other site
233413001815	L11 interface [polypeptide binding]; other site
233413001816	putative EF-Tu interaction site [polypeptide binding]; other site
233413001817	putative EF-G interaction site [polypeptide binding]; other site
233413001818	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413001819	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413001820	WHG domain; Region: WHG; pfam13305
233413001821	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
233413001822	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
233413001823	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
233413001824	Walker A/P-loop; other site
233413001825	ATP binding site [chemical binding]; other site
233413001826	Q-loop/lid; other site
233413001827	ABC transporter signature motif; other site
233413001828	Walker B; other site
233413001829	D-loop; other site
233413001830	H-loop/switch region; other site
233413001831	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
233413001832	putative active site [active]
233413001833	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
233413001834	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
233413001835	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
233413001836	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
233413001837	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
233413001838	Sulfatase; Region: Sulfatase; pfam00884
233413001839	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
233413001840	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
233413001841	putative active site [active]
233413001842	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
233413001843	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
233413001844	RPB12 interaction site [polypeptide binding]; other site
233413001845	RPB1 interaction site [polypeptide binding]; other site
233413001846	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
233413001847	RPB10 interaction site [polypeptide binding]; other site
233413001848	RPB11 interaction site [polypeptide binding]; other site
233413001849	RPB3 interaction site [polypeptide binding]; other site
233413001850	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
233413001851	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
233413001852	beta and beta' interface [polypeptide binding]; other site
233413001853	beta' and sigma factor interface [polypeptide binding]; other site
233413001854	Zn-binding [ion binding]; other site
233413001855	active site region [active]
233413001856	catalytic site [active]
233413001857	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
233413001858	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
233413001859	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
233413001860	G-loop; other site
233413001861	DNA binding site [nucleotide binding]
233413001862	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
233413001863	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
233413001864	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
233413001865	AP (apurinic/apyrimidinic) site pocket; other site
233413001866	DNA interaction; other site
233413001867	Metal-binding active site; metal-binding site
233413001868	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
233413001869	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
233413001870	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413001871	active site
233413001872	enoyl-CoA hydratase; Provisional; Region: PRK08272
233413001873	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413001874	substrate binding site [chemical binding]; other site
233413001875	oxyanion hole (OAH) forming residues; other site
233413001876	trimer interface [polypeptide binding]; other site
233413001877	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
233413001878	PaaX-like protein; Region: PaaX; pfam07848
233413001879	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
233413001880	enoyl-CoA hydratase; Provisional; Region: PRK08259
233413001881	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413001882	substrate binding site [chemical binding]; other site
233413001883	oxyanion hole (OAH) forming residues; other site
233413001884	trimer interface [polypeptide binding]; other site
233413001885	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413001886	MMPL family; Region: MMPL; pfam03176
233413001887	MMPL family; Region: MMPL; pfam03176
233413001888	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
233413001889	MarR family; Region: MarR_2; cl17246
233413001890	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
233413001891	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
233413001892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413001893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413001894	WHG domain; Region: WHG; pfam13305
233413001895	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
233413001896	S17 interaction site [polypeptide binding]; other site
233413001897	S8 interaction site; other site
233413001898	16S rRNA interaction site [nucleotide binding]; other site
233413001899	streptomycin interaction site [chemical binding]; other site
233413001900	23S rRNA interaction site [nucleotide binding]; other site
233413001901	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
233413001902	30S ribosomal protein S7; Validated; Region: PRK05302
233413001903	elongation factor G; Reviewed; Region: PRK00007
233413001904	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
233413001905	G1 box; other site
233413001906	putative GEF interaction site [polypeptide binding]; other site
233413001907	GTP/Mg2+ binding site [chemical binding]; other site
233413001908	Switch I region; other site
233413001909	G2 box; other site
233413001910	G3 box; other site
233413001911	Switch II region; other site
233413001912	G4 box; other site
233413001913	G5 box; other site
233413001914	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
233413001915	Elongation Factor G, domain II; Region: EFG_II; pfam14492
233413001916	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
233413001917	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
233413001918	elongation factor Tu; Reviewed; Region: PRK00049
233413001919	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
233413001920	G1 box; other site
233413001921	GEF interaction site [polypeptide binding]; other site
233413001922	GTP/Mg2+ binding site [chemical binding]; other site
233413001923	Switch I region; other site
233413001924	G2 box; other site
233413001925	G3 box; other site
233413001926	Switch II region; other site
233413001927	G4 box; other site
233413001928	G5 box; other site
233413001929	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
233413001930	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
233413001931	Antibiotic Binding Site [chemical binding]; other site
233413001932	Short C-terminal domain; Region: SHOCT; pfam09851
233413001933	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
233413001934	classical (c) SDRs; Region: SDR_c; cd05233
233413001935	NAD(P) binding site [chemical binding]; other site
233413001936	active site
233413001937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
233413001938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413001939	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413001940	Reductase C-terminal; Region: Reductase_C; pfam14759
233413001941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427
233413001942	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
233413001943	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413001944	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
233413001945	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
233413001946	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413001947	FeS/SAM binding site; other site
233413001948	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
233413001949	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
233413001950	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
233413001951	active site
233413001952	substrate binding site [chemical binding]; other site
233413001953	FMN binding site [chemical binding]; other site
233413001954	putative catalytic residues [active]
233413001955	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
233413001956	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
233413001957	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
233413001958	active site
233413001959	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
233413001960	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413001961	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
233413001962	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
233413001963	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
233413001964	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
233413001965	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
233413001966	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
233413001967	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
233413001968	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
233413001969	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
233413001970	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
233413001971	putative translocon binding site; other site
233413001972	protein-rRNA interface [nucleotide binding]; other site
233413001973	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
233413001974	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
233413001975	G-X-X-G motif; other site
233413001976	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
233413001977	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
233413001978	23S rRNA interface [nucleotide binding]; other site
233413001979	5S rRNA interface [nucleotide binding]; other site
233413001980	putative antibiotic binding site [chemical binding]; other site
233413001981	L25 interface [polypeptide binding]; other site
233413001982	L27 interface [polypeptide binding]; other site
233413001983	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
233413001984	putative translocon interaction site; other site
233413001985	23S rRNA interface [nucleotide binding]; other site
233413001986	signal recognition particle (SRP54) interaction site; other site
233413001987	L23 interface [polypeptide binding]; other site
233413001988	trigger factor interaction site; other site
233413001989	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
233413001990	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
233413001991	Sulfatase; Region: Sulfatase; cl19157
233413001992	Sulfatase; Region: Sulfatase; cl19157
233413001993	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
233413001994	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
233413001995	Uncharacterized conserved protein [Function unknown]; Region: COG1262
233413001996	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781
233413001997	Domain of unknown function (DUF4436); Region: DUF4436; pfam14494
233413001998	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
233413001999	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
233413002000	RNA binding site [nucleotide binding]; other site
233413002001	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
233413002002	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
233413002003	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
233413002004	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
233413002005	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
233413002006	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
233413002007	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
233413002008	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
233413002009	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
233413002010	5S rRNA interface [nucleotide binding]; other site
233413002011	L27 interface [polypeptide binding]; other site
233413002012	23S rRNA interface [nucleotide binding]; other site
233413002013	L5 interface [polypeptide binding]; other site
233413002014	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
233413002015	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
233413002016	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
233413002017	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
233413002018	23S rRNA binding site [nucleotide binding]; other site
233413002019	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
233413002020	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
233413002021	tandem repeat interface [polypeptide binding]; other site
233413002022	oligomer interface [polypeptide binding]; other site
233413002023	active site residues [active]
233413002024	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
233413002025	tandem repeat interface [polypeptide binding]; other site
233413002026	oligomer interface [polypeptide binding]; other site
233413002027	active site residues [active]
233413002028	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413002029	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413002030	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
233413002031	intersubunit interface [polypeptide binding]; other site
233413002032	active site
233413002033	Zn2+ binding site [ion binding]; other site
233413002034	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
233413002035	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
233413002036	NAD binding site [chemical binding]; other site
233413002037	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
233413002038	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
233413002039	nucleotide binding site [chemical binding]; other site
233413002040	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
233413002041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413002042	Coenzyme A binding pocket [chemical binding]; other site
233413002043	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
233413002044	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
233413002045	SecY translocase; Region: SecY; pfam00344
233413002046	adenylate kinase; Reviewed; Region: adk; PRK00279
233413002047	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
233413002048	AMP-binding site [chemical binding]; other site
233413002049	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
233413002050	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
233413002051	active site
233413002052	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
233413002053	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413002054	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413002055	DNA binding residues [nucleotide binding]
233413002056	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
233413002057	Putative zinc-finger; Region: zf-HC2; pfam13490
233413002058	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413002059	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
233413002060	putative DNA binding site [nucleotide binding]; other site
233413002061	putative Zn2+ binding site [ion binding]; other site
233413002062	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413002063	TIGR03086 family protein; Region: TIGR03086
233413002064	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
233413002065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
233413002066	Transposase; Region: DDE_Tnp_ISL3; pfam01610
233413002067	PE family; Region: PE; pfam00934
233413002068	Helix-turn-helix domain; Region: HTH_17; pfam12728
233413002069	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
233413002070	PE family; Region: PE; pfam00934
233413002071	PE family; Region: PE; pfam00934
233413002072	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413002073	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413002074	putative active site [active]
233413002075	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
233413002076	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
233413002077	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
233413002078	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413002079	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
233413002080	substrate binding pocket [chemical binding]; other site
233413002081	FAD binding site [chemical binding]; other site
233413002082	catalytic base [active]
233413002083	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
233413002084	tetrameric interface [polypeptide binding]; other site
233413002085	NAD binding site [chemical binding]; other site
233413002086	catalytic residues [active]
233413002087	PE family; Region: PE; pfam00934
233413002088	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
233413002089	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413002090	PPE family; Region: PPE; pfam00823
233413002091	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002092	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002093	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002094	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002095	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002096	Helix-turn-helix domain; Region: HTH_28; pfam13518
233413002097	Winged helix-turn helix; Region: HTH_29; pfam13551
233413002098	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
233413002099	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413002100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413002101	active site
233413002102	phosphorylation site [posttranslational modification]
233413002103	intermolecular recognition site; other site
233413002104	dimerization interface [polypeptide binding]; other site
233413002105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413002106	DNA binding site [nucleotide binding]
233413002107	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413002108	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413002109	dimerization interface [polypeptide binding]; other site
233413002110	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413002111	dimer interface [polypeptide binding]; other site
233413002112	phosphorylation site [posttranslational modification]
233413002113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413002114	ATP binding site [chemical binding]; other site
233413002115	Mg2+ binding site [ion binding]; other site
233413002116	G-X-G motif; other site
233413002117	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
233413002118	nucleotide binding site/active site [active]
233413002119	HIT family signature motif; other site
233413002120	catalytic residue [active]
233413002121	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
233413002122	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
233413002123	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
233413002124	NAD binding site [chemical binding]; other site
233413002125	catalytic Zn binding site [ion binding]; other site
233413002126	substrate binding site [chemical binding]; other site
233413002127	structural Zn binding site [ion binding]; other site
233413002128	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
233413002129	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
233413002130	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413002131	short chain dehydrogenase; Provisional; Region: PRK07775
233413002132	classical (c) SDRs; Region: SDR_c; cd05233
233413002133	NAD(P) binding site [chemical binding]; other site
233413002134	active site
233413002135	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413002136	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413002137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413002138	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
233413002139	NAD binding site [chemical binding]; other site
233413002140	catalytic residues [active]
233413002141	short chain dehydrogenase; Provisional; Region: PRK07774
233413002142	classical (c) SDRs; Region: SDR_c; cd05233
233413002143	NAD(P) binding site [chemical binding]; other site
233413002144	active site
233413002145	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
233413002146	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
233413002147	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
233413002148	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
233413002149	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
233413002150	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
233413002151	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
233413002152	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
233413002153	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
233413002154	Predicted esterase [General function prediction only]; Region: COG0627
233413002155	S-formylglutathione hydrolase; Region: PLN02442
233413002156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
233413002157	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413002158	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
233413002159	adenylosuccinate lyase; Region: purB; TIGR00928
233413002160	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
233413002161	tetramer interface [polypeptide binding]; other site
233413002162	active site
233413002163	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413002164	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
233413002165	ATP binding site [chemical binding]; other site
233413002166	active site
233413002167	phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959
233413002168	substrate binding site [chemical binding]; other site
233413002169	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
233413002170	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
233413002171	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
233413002172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413002173	putative substrate translocation pore; other site
233413002174	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
233413002175	putative active site [active]
233413002176	putative Zn binding site [ion binding]; other site
233413002177	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
233413002178	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
233413002179	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
233413002180	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
233413002181	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
233413002182	putative active site [active]
233413002183	catalytic triad [active]
233413002184	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
233413002185	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
233413002186	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
233413002187	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
233413002188	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413002189	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413002190	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
233413002191	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
233413002192	DNA-binding site [nucleotide binding]; DNA binding site
233413002193	UTRA domain; Region: UTRA; pfam07702
233413002194	Uncharacterized conserved protein [Function unknown]; Region: COG1359
233413002195	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
233413002196	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
233413002197	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413002198	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
233413002199	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
233413002200	NAD binding site [chemical binding]; other site
233413002201	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413002202	Transposase; Region: DEDD_Tnp_IS110; pfam01548
233413002203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
233413002204	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
233413002205	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
233413002206	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
233413002207	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
233413002208	active site
233413002209	metal binding site [ion binding]; metal-binding site
233413002210	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
233413002211	active site
233413002212	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
233413002213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
233413002214	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
233413002215	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
233413002216	dimerization interface [polypeptide binding]; other site
233413002217	ATP binding site [chemical binding]; other site
233413002218	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
233413002219	dimerization interface [polypeptide binding]; other site
233413002220	ATP binding site [chemical binding]; other site
233413002221	CAAX protease self-immunity; Region: Abi; pfam02517
233413002222	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
233413002223	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
233413002224	active site
233413002225	metal binding site [ion binding]; metal-binding site
233413002226	hexamer interface [polypeptide binding]; other site
233413002227	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
233413002228	amidophosphoribosyltransferase; Provisional; Region: PRK07847
233413002229	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
233413002230	active site
233413002231	tetramer interface [polypeptide binding]; other site
233413002232	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413002233	active site
233413002234	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
233413002235	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
233413002236	dimerization interface [polypeptide binding]; other site
233413002237	putative ATP binding site [chemical binding]; other site
233413002238	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
233413002239	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
233413002240	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
233413002241	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
233413002242	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
233413002243	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
233413002244	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413002245	catalytic residue [active]
233413002246	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
233413002247	heme-binding site [chemical binding]; other site
233413002248	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
233413002249	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
233413002250	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
233413002251	active site residue [active]
233413002252	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
233413002253	active site residue [active]
233413002254	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
233413002255	catalytic residues [active]
233413002256	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
233413002257	DNA-binding response regulator CreB; Provisional; Region: PRK11083
233413002258	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413002259	DNA binding site [nucleotide binding]
233413002260	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
233413002261	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413002262	Coenzyme A binding pocket [chemical binding]; other site
233413002263	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413002264	Coenzyme A binding pocket [chemical binding]; other site
233413002265	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
233413002266	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
233413002267	Walker A/P-loop; other site
233413002268	ATP binding site [chemical binding]; other site
233413002269	Q-loop/lid; other site
233413002270	ABC transporter signature motif; other site
233413002271	Walker B; other site
233413002272	D-loop; other site
233413002273	H-loop/switch region; other site
233413002274	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
233413002275	PhoU domain; Region: PhoU; pfam01895
233413002276	PhoU domain; Region: PhoU; pfam01895
233413002277	cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350
233413002278	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
233413002279	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
233413002280	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
233413002281	FMN binding site [chemical binding]; other site
233413002282	active site
233413002283	catalytic residues [active]
233413002284	substrate binding site [chemical binding]; other site
233413002285	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
233413002286	homodimer interface [polypeptide binding]; other site
233413002287	putative substrate binding pocket [chemical binding]; other site
233413002288	diiron center [ion binding]; other site
233413002289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413002290	Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382
233413002291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
233413002292	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413002293	dimerization interface [polypeptide binding]; other site
233413002294	putative DNA binding site [nucleotide binding]; other site
233413002295	putative Zn2+ binding site [ion binding]; other site
233413002296	Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590
233413002297	active site
233413002298	Zn binding site [ion binding]; other site
233413002299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
233413002300	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
233413002301	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413002302	TIGR04255 family protein; Region: sporadTIGR04255
233413002303	PE family; Region: PE; pfam00934
233413002304	PE family; Region: PE; pfam00934
233413002305	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413002306	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
233413002307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
233413002308	D-ala-D-ala dipeptidase; Region: Peptidase_M15; pfam01427
233413002309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413002310	S-adenosylmethionine binding site [chemical binding]; other site
233413002311	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
233413002312	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413002313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413002314	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413002315	putative substrate translocation pore; other site
233413002316	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
233413002317	tetramer interface [polypeptide binding]; other site
233413002318	TPP-binding site [chemical binding]; other site
233413002319	heterodimer interface [polypeptide binding]; other site
233413002320	phosphorylation loop region [posttranslational modification]
233413002321	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413002322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413002323	active site
233413002324	phosphorylation site [posttranslational modification]
233413002325	intermolecular recognition site; other site
233413002326	dimerization interface [polypeptide binding]; other site
233413002327	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413002328	DNA binding residues [nucleotide binding]
233413002329	dimerization interface [polypeptide binding]; other site
233413002330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413002331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413002332	ATP binding site [chemical binding]; other site
233413002333	Mg2+ binding site [ion binding]; other site
233413002334	G-X-G motif; other site
233413002335	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
233413002336	The first cupredoxin domain of CumA like multicopper oxidase; Region: CuRO_1_CumA_like; cd13861
233413002337	putative Domain 2 interface [polypeptide binding]; other site
233413002338	putative Domain 3 interface [polypeptide binding]; other site
233413002339	trinuclear Cu binding site [ion binding]; other site
233413002340	The second cupredoxin domain of CopA copper resistance protein like family; Region: CuRO_2_CopA_like_1; cd13870
233413002341	putative Domain 1 interface [polypeptide binding]; other site
233413002342	putative Domain 3 interface [polypeptide binding]; other site
233413002343	The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896
233413002344	putative Domain 2 interface [polypeptide binding]; other site
233413002345	Type 1 (T1) Cu binding site [ion binding]; other site
233413002346	putative Domain 1 interface [polypeptide binding]; other site
233413002347	trinuclear Cu binding site [ion binding]; other site
233413002348	cysteine synthase; Region: PLN02565
233413002349	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
233413002350	dimer interface [polypeptide binding]; other site
233413002351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413002352	catalytic residue [active]
233413002353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413002354	multidrug resistance protein MdtH; Provisional; Region: PRK11646
233413002355	putative substrate translocation pore; other site
233413002356	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
233413002357	hypothetical protein; Provisional; Region: PRK06194
233413002358	classical (c) SDRs; Region: SDR_c; cd05233
233413002359	NAD(P) binding site [chemical binding]; other site
233413002360	active site
233413002361	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413002362	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
233413002363	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
233413002364	dimer interface [polypeptide binding]; other site
233413002365	PYR/PP interface [polypeptide binding]; other site
233413002366	TPP binding site [chemical binding]; other site
233413002367	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
233413002368	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
233413002369	TPP-binding site [chemical binding]; other site
233413002370	dimer interface [polypeptide binding]; other site
233413002371	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
233413002372	putative hydrophobic ligand binding site [chemical binding]; other site
233413002373	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
233413002374	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
233413002375	putative hydrophobic ligand binding site [chemical binding]; other site
233413002376	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
233413002377	putative hydrophobic ligand binding site [chemical binding]; other site
233413002378	aminotransferase; Validated; Region: PRK07777
233413002379	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413002380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413002381	homodimer interface [polypeptide binding]; other site
233413002382	catalytic residue [active]
233413002383	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
233413002384	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
233413002385	dimer interface [polypeptide binding]; other site
233413002386	active site
233413002387	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
233413002388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413002389	substrate binding site [chemical binding]; other site
233413002390	oxyanion hole (OAH) forming residues; other site
233413002391	trimer interface [polypeptide binding]; other site
233413002392	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
233413002393	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
233413002394	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
233413002395	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
233413002396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413002397	ATP binding site [chemical binding]; other site
233413002398	putative Mg++ binding site [ion binding]; other site
233413002399	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413002400	nucleotide binding region [chemical binding]; other site
233413002401	ATP-binding site [chemical binding]; other site
233413002402	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
233413002403	WYL domain; Region: WYL; pfam13280
233413002404	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
233413002405	trimer interface [polypeptide binding]; other site
233413002406	dimer interface [polypeptide binding]; other site
233413002407	putative active site [active]
233413002408	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
233413002409	MPT binding site; other site
233413002410	trimer interface [polypeptide binding]; other site
233413002411	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
233413002412	MoaE homodimer interface [polypeptide binding]; other site
233413002413	MoaD interaction [polypeptide binding]; other site
233413002414	active site residues [active]
233413002415	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
233413002416	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
233413002417	MoaE interaction surface [polypeptide binding]; other site
233413002418	MoeB interaction surface [polypeptide binding]; other site
233413002419	thiocarboxylated glycine; other site
233413002420	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
233413002421	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413002422	FeS/SAM binding site; other site
233413002423	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
233413002424	hypothetical protein; Provisional; Region: PRK11770
233413002425	Domain of unknown function (DUF307); Region: DUF307; pfam03733
233413002426	Domain of unknown function (DUF307); Region: DUF307; pfam03733
233413002427	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
233413002428	DNA-binding site [nucleotide binding]; DNA binding site
233413002429	RNA-binding motif; other site
233413002430	PE family; Region: PE; pfam00934
233413002431	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413002432	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413002433	active site
233413002434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
233413002435	FIST N domain; Region: FIST; pfam08495
233413002436	FIST C domain; Region: FIST_C; pfam10442
233413002437	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
233413002438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413002439	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413002440	putative substrate translocation pore; other site
233413002441	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
233413002442	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413002443	PPE family; Region: PPE; pfam00823
233413002444	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002445	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002446	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413002447	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
233413002448	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413002449	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
233413002450	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
233413002451	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
233413002452	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
233413002453	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
233413002454	phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
233413002455	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413002456	catalytic residue [active]
233413002457	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
233413002458	Ferredoxin [Energy production and conversion]; Region: COG1146
233413002459	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
233413002460	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
233413002461	ferredoxin-NADP+ reductase; Region: PLN02852
233413002462	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413002463	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
233413002464	putative dimer interface [polypeptide binding]; other site
233413002465	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
233413002466	putative catalytic site [active]
233413002467	putative phosphate binding site [ion binding]; other site
233413002468	putative metal binding site [ion binding]; other site
233413002469	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
233413002470	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
233413002471	dimer interface [polypeptide binding]; other site
233413002472	active site
233413002473	citrylCoA binding site [chemical binding]; other site
233413002474	oxalacetate/citrate binding site [chemical binding]; other site
233413002475	coenzyme A binding site [chemical binding]; other site
233413002476	catalytic triad [active]
233413002477	Predicted ATPase [General function prediction only]; Region: COG3903
233413002478	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413002479	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413002480	DNA binding residues [nucleotide binding]
233413002481	dimerization interface [polypeptide binding]; other site
233413002482	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413002483	cyclase homology domain; Region: CHD; cd07302
233413002484	nucleotidyl binding site; other site
233413002485	metal binding site [ion binding]; metal-binding site
233413002486	dimer interface [polypeptide binding]; other site
233413002487	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413002488	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
233413002489	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
233413002490	Predicted ATPase [General function prediction only]; Region: COG3903
233413002491	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413002492	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413002493	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
233413002494	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
233413002495	dimer interface [polypeptide binding]; other site
233413002496	active site
233413002497	citrylCoA binding site [chemical binding]; other site
233413002498	NADH binding [chemical binding]; other site
233413002499	cationic pore residues; other site
233413002500	oxalacetate/citrate binding site [chemical binding]; other site
233413002501	coenzyme A binding site [chemical binding]; other site
233413002502	catalytic triad [active]
233413002503	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
233413002504	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413002505	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
233413002506	BON domain; Region: BON; pfam04972
233413002507	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
233413002508	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
233413002509	ligand binding site [chemical binding]; other site
233413002510	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
233413002511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413002512	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413002513	dimerization interface [polypeptide binding]; other site
233413002514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413002515	dimer interface [polypeptide binding]; other site
233413002516	phosphorylation site [posttranslational modification]
233413002517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413002518	ATP binding site [chemical binding]; other site
233413002519	Mg2+ binding site [ion binding]; other site
233413002520	G-X-G motif; other site
233413002521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413002522	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413002523	active site
233413002524	phosphorylation site [posttranslational modification]
233413002525	intermolecular recognition site; other site
233413002526	dimerization interface [polypeptide binding]; other site
233413002527	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413002528	DNA binding site [nucleotide binding]
233413002529	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
233413002530	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
233413002531	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
233413002532	enoyl-CoA hydratase; Provisional; Region: PRK07854
233413002533	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413002534	substrate binding site [chemical binding]; other site
233413002535	oxyanion hole (OAH) forming residues; other site
233413002536	trimer interface [polypeptide binding]; other site
233413002537	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
233413002538	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
233413002539	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
233413002540	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
233413002541	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413002542	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
233413002543	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
233413002544	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
233413002545	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
233413002546	hydrophobic ligand binding site; other site
233413002547	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
233413002548	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
233413002549	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
233413002550	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
233413002551	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
233413002552	active site
233413002553	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413002554	PPE family; Region: PPE; pfam00823
233413002555	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413002556	PE family; Region: PE; pfam00934
233413002557	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
233413002558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
233413002559	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413002560	Coenzyme A binding pocket [chemical binding]; other site
233413002561	Transposase, Mutator family; Region: Transposase_mut; pfam00872
233413002562	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413002563	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
233413002564	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
233413002565	catalytic residues [active]
233413002566	catalytic nucleophile [active]
233413002567	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
233413002568	Probable transposase; Region: OrfB_IS605; pfam01385
233413002569	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
233413002570	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
233413002571	putative active site pocket [active]
233413002572	dimerization interface [polypeptide binding]; other site
233413002573	putative catalytic residue [active]
233413002574	Phage-related replication protein [General function prediction only]; Region: COG4195
233413002575	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
233413002576	manganese transport protein MntH; Reviewed; Region: PRK00701
233413002577	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
233413002578	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
233413002579	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
233413002580	short chain dehydrogenase; Provisional; Region: PRK07814
233413002581	classical (c) SDRs; Region: SDR_c; cd05233
233413002582	NAD(P) binding site [chemical binding]; other site
233413002583	active site
233413002584	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
233413002585	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
233413002586	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413002587	dimer interface [polypeptide binding]; other site
233413002588	conserved gate region; other site
233413002589	putative PBP binding loops; other site
233413002590	ABC-ATPase subunit interface; other site
233413002591	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
233413002592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413002593	dimer interface [polypeptide binding]; other site
233413002594	conserved gate region; other site
233413002595	putative PBP binding loops; other site
233413002596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
233413002597	ABC-ATPase subunit interface; other site
233413002598	Uncharacterized conserved protein [Function unknown]; Region: COG3391
233413002599	SdiA-regulated; Region: SdiA-regulated; cl19046
233413002600	putative active site [active]
233413002601	NHL repeat; Region: NHL; pfam01436
233413002602	NHL repeat; Region: NHL; pfam01436
233413002603	NHL repeat; Region: NHL; pfam01436
233413002604	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413002605	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413002606	active site
233413002607	ATP binding site [chemical binding]; other site
233413002608	substrate binding site [chemical binding]; other site
233413002609	activation loop (A-loop); other site
233413002610	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
233413002611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413002612	Walker A/P-loop; other site
233413002613	ATP binding site [chemical binding]; other site
233413002614	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
233413002615	Q-loop/lid; other site
233413002616	ABC transporter signature motif; other site
233413002617	Walker B; other site
233413002618	D-loop; other site
233413002619	H-loop/switch region; other site
233413002620	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
233413002621	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
233413002622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413002623	dimer interface [polypeptide binding]; other site
233413002624	conserved gate region; other site
233413002625	putative PBP binding loops; other site
233413002626	ABC-ATPase subunit interface; other site
233413002627	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
233413002628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413002629	dimer interface [polypeptide binding]; other site
233413002630	conserved gate region; other site
233413002631	putative PBP binding loops; other site
233413002632	ABC-ATPase subunit interface; other site
233413002633	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
233413002634	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
233413002635	putative DNA binding site [nucleotide binding]; other site
233413002636	putative homodimer interface [polypeptide binding]; other site
233413002637	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
233413002638	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
233413002639	nucleotide binding site [chemical binding]; other site
233413002640	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
233413002641	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
233413002642	active site
233413002643	DNA binding site [nucleotide binding]
233413002644	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
233413002645	DNA binding site [nucleotide binding]
233413002646	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
233413002647	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
233413002648	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
233413002649	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413002650	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
233413002651	anti sigma factor interaction site; other site
233413002652	regulatory phosphorylation site [posttranslational modification]; other site
233413002653	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413002654	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
233413002655	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
233413002656	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
233413002657	short chain dehydrogenase; Provisional; Region: PRK07024
233413002658	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
233413002659	putative NAD(P) binding site [chemical binding]; other site
233413002660	active site
233413002661	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
233413002662	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
233413002663	active site
233413002664	dimer interface [polypeptide binding]; other site
233413002665	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
233413002666	dimer interface [polypeptide binding]; other site
233413002667	active site
233413002668	Predicted esterase [General function prediction only]; Region: COG0627
233413002669	hypothetical protein; Provisional; Region: PRK07857
233413002670	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
233413002671	Part of AAA domain; Region: AAA_19; pfam13245
233413002672	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
233413002673	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
233413002674	Peptidase family M23; Region: Peptidase_M23; pfam01551
233413002675	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
233413002676	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
233413002677	CoA-ligase; Region: Ligase_CoA; pfam00549
233413002678	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
233413002679	CoA binding domain; Region: CoA_binding; smart00881
233413002680	CoA-ligase; Region: Ligase_CoA; pfam00549
233413002681	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
233413002682	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
233413002683	active site
233413002684	substrate binding site [chemical binding]; other site
233413002685	cosubstrate binding site; other site
233413002686	catalytic site [active]
233413002687	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
233413002688	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
233413002689	purine monophosphate binding site [chemical binding]; other site
233413002690	dimer interface [polypeptide binding]; other site
233413002691	putative catalytic residues [active]
233413002692	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; pfam01808
233413002693	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
233413002694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
233413002695	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
233413002696	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
233413002697	metal ion-dependent adhesion site (MIDAS); other site
233413002698	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
233413002699	homotetrameric interface [polypeptide binding]; other site
233413002700	putative active site [active]
233413002701	metal binding site [ion binding]; metal-binding site
233413002702	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
233413002703	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
233413002704	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
233413002705	putative homodimer interface [polypeptide binding]; other site
233413002706	putative homotetramer interface [polypeptide binding]; other site
233413002707	allosteric switch controlling residues; other site
233413002708	putative metal binding site [ion binding]; other site
233413002709	putative homodimer-homodimer interface [polypeptide binding]; other site
233413002710	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
233413002711	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
233413002712	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413002713	Soluble P-type ATPase [General function prediction only]; Region: COG4087
233413002714	enoyl-CoA hydratase; Provisional; Region: PRK07827
233413002715	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413002716	substrate binding site [chemical binding]; other site
233413002717	oxyanion hole (OAH) forming residues; other site
233413002718	trimer interface [polypeptide binding]; other site
233413002719	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413002720	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
233413002721	active site
233413002722	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
233413002723	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
233413002724	ATP-grasp domain; Region: ATP-grasp_4; cl17255
233413002725	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
233413002726	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
233413002727	carboxyltransferase (CT) interaction site; other site
233413002728	biotinylation site [posttranslational modification]; other site
233413002729	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
233413002730	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413002731	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413002732	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413002733	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413002734	active site
233413002735	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
233413002736	PE family; Region: PE; pfam00934
233413002737	PE family; Region: PE; pfam00934
233413002738	Uncharacterized conserved protein [Function unknown]; Region: COG3391
233413002739	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
233413002740	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
233413002741	PE family; Region: PE; pfam00934
233413002742	Uncharacterized conserved protein [Function unknown]; Region: COG3391
233413002743	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
233413002744	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
233413002745	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
233413002746	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413002747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413002748	active site
233413002749	phosphorylation site [posttranslational modification]
233413002750	intermolecular recognition site; other site
233413002751	dimerization interface [polypeptide binding]; other site
233413002752	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413002753	DNA binding site [nucleotide binding]
233413002754	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
233413002755	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413002756	dimerization interface [polypeptide binding]; other site
233413002757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413002758	dimer interface [polypeptide binding]; other site
233413002759	phosphorylation site [posttranslational modification]
233413002760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413002761	ATP binding site [chemical binding]; other site
233413002762	Mg2+ binding site [ion binding]; other site
233413002763	G-X-G motif; other site
233413002764	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
233413002765	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
233413002766	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
233413002767	MPT binding site; other site
233413002768	trimer interface [polypeptide binding]; other site
233413002769	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
233413002770	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
233413002771	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
233413002772	Walker A/P-loop; other site
233413002773	ATP binding site [chemical binding]; other site
233413002774	Q-loop/lid; other site
233413002775	ABC transporter signature motif; other site
233413002776	Walker B; other site
233413002777	D-loop; other site
233413002778	H-loop/switch region; other site
233413002779	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
233413002780	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
233413002781	FtsX-like permease family; Region: FtsX; pfam02687
233413002782	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
233413002783	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
233413002784	FtsX-like permease family; Region: FtsX; pfam02687
233413002785	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
233413002786	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
233413002787	substrate binding pocket [chemical binding]; other site
233413002788	chain length determination region; other site
233413002789	substrate-Mg2+ binding site; other site
233413002790	catalytic residues [active]
233413002791	aspartate-rich region 1; other site
233413002792	active site lid residues [active]
233413002793	aspartate-rich region 2; other site
233413002794	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
233413002795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
233413002796	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
233413002797	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
233413002798	active site
233413002799	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
233413002800	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
233413002801	dimer interface [polypeptide binding]; other site
233413002802	putative functional site; other site
233413002803	putative MPT binding site; other site
233413002804	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
233413002805	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
233413002806	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413002807	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413002808	ligand binding site [chemical binding]; other site
233413002809	flexible hinge region; other site
233413002810	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
233413002811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413002812	Coenzyme A binding pocket [chemical binding]; other site
233413002813	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
233413002814	arginine deiminase; Provisional; Region: PRK01388
233413002815	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
233413002816	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
233413002817	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
233413002818	putative SAM binding site [chemical binding]; other site
233413002819	putative homodimer interface [polypeptide binding]; other site
233413002820	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
233413002821	chorismate binding enzyme; Region: Chorismate_bind; cl10555
233413002822	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
233413002823	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
233413002824	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
233413002825	active site
233413002826	HIGH motif; other site
233413002827	KMSKS motif; other site
233413002828	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
233413002829	tRNA binding surface [nucleotide binding]; other site
233413002830	anticodon binding site; other site
233413002831	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
233413002832	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
233413002833	active site
233413002834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
233413002835	Domain of unknown function (DUF348); Region: DUF348; pfam03990
233413002836	Domain of unknown function (DUF348); Region: DUF348; pfam03990
233413002837	Domain of unknown function (DUF348); Region: DUF348; pfam03990
233413002838	G5 domain; Region: G5; pfam07501
233413002839	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
233413002840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413002841	S-adenosylmethionine binding site [chemical binding]; other site
233413002842	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
233413002843	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
233413002844	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
233413002845	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
233413002846	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413002847	acyl-activating enzyme (AAE) consensus motif; other site
233413002848	AMP binding site [chemical binding]; other site
233413002849	active site
233413002850	CoA binding site [chemical binding]; other site
233413002851	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
233413002852	putative active site [active]
233413002853	catalytic residue [active]
233413002854	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
233413002855	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
233413002856	5S rRNA interface [nucleotide binding]; other site
233413002857	CTC domain interface [polypeptide binding]; other site
233413002858	L16 interface [polypeptide binding]; other site
233413002859	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
233413002860	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
233413002861	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
233413002862	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
233413002863	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413002864	active site
233413002865	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
233413002866	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
233413002867	Substrate binding site; other site
233413002868	Mg++ binding site; other site
233413002869	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
233413002870	active site
233413002871	substrate binding site [chemical binding]; other site
233413002872	CoA binding site [chemical binding]; other site
233413002873	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413002874	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413002875	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
233413002876	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
233413002877	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413002878	ATP binding site [chemical binding]; other site
233413002879	putative Mg++ binding site [ion binding]; other site
233413002880	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413002881	nucleotide binding region [chemical binding]; other site
233413002882	ATP-binding site [chemical binding]; other site
233413002883	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
233413002884	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
233413002885	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
233413002886	homodimer interface [polypeptide binding]; other site
233413002887	metal binding site [ion binding]; metal-binding site
233413002888	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
233413002889	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
233413002890	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
233413002891	N-acetyl-D-glucosamine binding site [chemical binding]; other site
233413002892	enolase; Provisional; Region: eno; PRK00077
233413002893	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
233413002894	dimer interface [polypeptide binding]; other site
233413002895	metal binding site [ion binding]; metal-binding site
233413002896	substrate binding pocket [chemical binding]; other site
233413002897	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
233413002898	Uncharacterized conserved protein [Function unknown]; Region: COG1507
233413002899	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
233413002900	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
233413002901	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
233413002902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413002903	active site
233413002904	phosphorylation site [posttranslational modification]
233413002905	intermolecular recognition site; other site
233413002906	dimerization interface [polypeptide binding]; other site
233413002907	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413002908	DNA binding site [nucleotide binding]
233413002909	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
233413002910	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
233413002911	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
233413002912	Ligand Binding Site [chemical binding]; other site
233413002913	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
233413002914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413002915	dimer interface [polypeptide binding]; other site
233413002916	phosphorylation site [posttranslational modification]
233413002917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413002918	ATP binding site [chemical binding]; other site
233413002919	Mg2+ binding site [ion binding]; other site
233413002920	G-X-G motif; other site
233413002921	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
233413002922	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
233413002923	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413002924	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
233413002925	potassium-transporting ATPase subunit C; Provisional; Region: PRK14001
233413002926	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413002927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413002928	dimer interface [polypeptide binding]; other site
233413002929	phosphorylation site [posttranslational modification]
233413002930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413002931	ATP binding site [chemical binding]; other site
233413002932	Mg2+ binding site [ion binding]; other site
233413002933	G-X-G motif; other site
233413002934	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413002935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413002936	active site
233413002937	phosphorylation site [posttranslational modification]
233413002938	intermolecular recognition site; other site
233413002939	dimerization interface [polypeptide binding]; other site
233413002940	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413002941	DNA binding site [nucleotide binding]
233413002942	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
233413002943	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
233413002944	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
233413002945	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
233413002946	Transposase domain (DUF772); Region: DUF772; pfam05598
233413002947	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
233413002948	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
233413002949	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413002950	PPE family; Region: PPE; pfam00823
233413002951	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413002952	PE family; Region: PE; pfam00934
233413002953	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413002954	Mb1070c, -, len: 183 aa. Equivalent to Rv1041c, len: 287 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 183 aa overlap). Probable IS like-2 transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (186 aa), FASTA scores: opt: 173, E(): 0.00016, (40.9% identity in 176 aa overlap). Similar to Rv1150, C-terminal part of transposase of  Mycobacterium tuberculosis IS like-1. MTCY10G2.07 and MTCY10G2.08 are frameshifted with respect to Mycobacterium tuberculosis Q50761 transposase, the 10G2 cosmid sequence appears to be correct.; IS LIKE-2 TRANSPOSASE
233413002955	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
233413002956	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
233413002957	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
233413002958	Predicted transcriptional regulator [Transcription]; Region: COG5340
233413002959	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
233413002960	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
233413002961	Transposase, Mutator family; Region: Transposase_mut; pfam00872
233413002962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413002963	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413002964	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
233413002965	putative DNA binding site [nucleotide binding]; other site
233413002966	putative Zn2+ binding site [ion binding]; other site
233413002967	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
233413002968	classical (c) SDRs; Region: SDR_c; cd05233
233413002969	NAD(P) binding site [chemical binding]; other site
233413002970	active site
233413002971	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
233413002972	Helix-turn-helix domain; Region: HTH_17; pfam12728
233413002973	mobile mystery protein B; Region: mob_myst_B; TIGR02613
233413002974	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
233413002975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
233413002976	Uncharacterized conserved protein [Function unknown]; Region: COG3391
233413002977	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
233413002978	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
233413002979	dimer interface [polypeptide binding]; other site
233413002980	acyl-activating enzyme (AAE) consensus motif; other site
233413002981	putative active site [active]
233413002982	AMP binding site [chemical binding]; other site
233413002983	putative CoA binding site [chemical binding]; other site
233413002984	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
233413002985	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
233413002986	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
233413002987	hydrophobic ligand binding site; other site
233413002988	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
233413002989	putative active site [active]
233413002990	putative dimer interface [polypeptide binding]; other site
233413002991	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
233413002992	Patatin-like phospholipase; Region: Patatin; pfam01734
233413002993	active site
233413002994	nucleophile elbow; other site
233413002995	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
233413002996	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
233413002997	active site
233413002998	nucleophile elbow; other site
233413002999	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
233413003000	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
233413003001	active site residue [active]
233413003002	PE family; Region: PE; pfam00934
233413003003	PE family; Region: PE; pfam00934
233413003004	Predicted membrane protein [Function unknown]; Region: COG4425
233413003005	Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420
233413003006	Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081
233413003007	enoyl-CoA hydratase; Provisional; Region: PRK05862
233413003008	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413003009	substrate binding site [chemical binding]; other site
233413003010	oxyanion hole (OAH) forming residues; other site
233413003011	trimer interface [polypeptide binding]; other site
233413003012	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
233413003013	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
233413003014	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413003015	substrate binding site [chemical binding]; other site
233413003016	oxyanion hole (OAH) forming residues; other site
233413003017	trimer interface [polypeptide binding]; other site
233413003018	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
233413003019	Predicted membrane protein [Function unknown]; Region: COG4760
233413003020	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
233413003021	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
233413003022	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
233413003023	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
233413003024	dimer interface [polypeptide binding]; other site
233413003025	active site
233413003026	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
233413003027	active site
233413003028	catalytic triad [active]
233413003029	oxyanion hole [active]
233413003030	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
233413003031	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413003032	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
233413003033	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
233413003034	dimer interface [polypeptide binding]; other site
233413003035	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413003036	catalytic residue [active]
233413003037	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
233413003038	RDD family; Region: RDD; pfam06271
233413003039	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
233413003040	homodimer interface [polypeptide binding]; other site
233413003041	substrate-cofactor binding pocket; other site
233413003042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413003043	catalytic residue [active]
233413003044	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
233413003045	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
233413003046	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
233413003047	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
233413003048	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
233413003049	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
233413003050	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
233413003051	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
233413003052	catalytic residues [active]
233413003053	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
233413003054	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
233413003055	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
233413003056	active site
233413003057	dimer interface [polypeptide binding]; other site
233413003058	PE family; Region: PE; pfam00934
233413003059	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
233413003060	dimer interface [polypeptide binding]; other site
233413003061	PE family; Region: PE; pfam00934
233413003062	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670
233413003063	PE family; Region: PE; pfam00934
233413003064	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
233413003065	ATP-binding site [chemical binding]; other site
233413003066	CoA-binding site [chemical binding]; other site
233413003067	Mg2+-binding site [ion binding]; other site
233413003068	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
233413003069	dimer interface [polypeptide binding]; other site
233413003070	active site
233413003071	glycine-pyridoxal phosphate binding site [chemical binding]; other site
233413003072	folate binding site [chemical binding]; other site
233413003073	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
233413003074	dinuclear metal binding motif [ion binding]; other site
233413003075	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
233413003076	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
233413003077	putative active site [active]
233413003078	PhoH-like protein; Region: PhoH; pfam02562
233413003079	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
233413003080	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
233413003081	NodB motif; other site
233413003082	active site
233413003083	catalytic site [active]
233413003084	metal binding site [ion binding]; metal-binding site
233413003085	fumarate hydratase; Reviewed; Region: fumC; PRK00485
233413003086	Class II fumarases; Region: Fumarase_classII; cd01362
233413003087	active site
233413003088	tetramer interface [polypeptide binding]; other site
233413003089	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
233413003090	putative active site [active]
233413003091	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
233413003092	Domain of unknown function DUF20; Region: UPF0118; pfam01594
233413003093	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
233413003094	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
233413003095	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
233413003096	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
233413003097	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413003098	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
233413003099	putative NAD(P) binding site [chemical binding]; other site
233413003100	active site
233413003101	putative substrate binding site [chemical binding]; other site
233413003102	exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280
233413003103	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
233413003104	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
233413003105	generic binding surface II; other site
233413003106	generic binding surface I; other site
233413003107	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
233413003108	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
233413003109	Fe-S cluster binding site [ion binding]; other site
233413003110	substrate binding site [chemical binding]; other site
233413003111	catalytic site [active]
233413003112	Yip1 domain; Region: Yip1; pfam04893
233413003113	GTP-binding protein YchF; Reviewed; Region: PRK09601
233413003114	YchF GTPase; Region: YchF; cd01900
233413003115	G1 box; other site
233413003116	GTP/Mg2+ binding site [chemical binding]; other site
233413003117	Switch I region; other site
233413003118	G2 box; other site
233413003119	Switch II region; other site
233413003120	G3 box; other site
233413003121	G4 box; other site
233413003122	G5 box; other site
233413003123	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
233413003124	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
233413003125	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413003126	putative active site [active]
233413003127	Uncharacterized conserved protein [Function unknown]; Region: COG1359
233413003128	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413003129	cyclase homology domain; Region: CHD; cd07302
233413003130	nucleotidyl binding site; other site
233413003131	metal binding site [ion binding]; metal-binding site
233413003132	dimer interface [polypeptide binding]; other site
233413003133	glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871
233413003134	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
233413003135	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
233413003136	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
233413003137	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
233413003138	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
233413003139	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413003140	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413003141	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413003142	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413003143	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413003144	pyruvate phosphate dikinase; Provisional; Region: PRK05878
233413003145	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
233413003146	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
233413003147	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413003148	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413003149	active site
233413003150	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
233413003151	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413003152	non-specific DNA binding site [nucleotide binding]; other site
233413003153	salt bridge; other site
233413003154	sequence-specific DNA binding site [nucleotide binding]; other site
233413003155	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
233413003156	Domain of unknown function (DUF955); Region: DUF955; pfam06114
233413003157	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
233413003158	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
233413003159	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
233413003160	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
233413003161	dimer interface [polypeptide binding]; other site
233413003162	active site
233413003163	citrylCoA binding site [chemical binding]; other site
233413003164	oxalacetate/citrate binding site [chemical binding]; other site
233413003165	coenzyme A binding site [chemical binding]; other site
233413003166	catalytic triad [active]
233413003167	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
233413003168	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
233413003169	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
233413003170	THF binding site; other site
233413003171	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
233413003172	substrate binding site [chemical binding]; other site
233413003173	THF binding site; other site
233413003174	zinc-binding site [ion binding]; other site
233413003175	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413003176	PPE family; Region: PPE; pfam00823
233413003177	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413003178	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413003179	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413003180	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413003181	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413003182	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413003183	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
233413003184	active site
233413003185	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
233413003186	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413003187	substrate binding site [chemical binding]; other site
233413003188	oxyanion hole (OAH) forming residues; other site
233413003189	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
233413003190	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413003191	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413003192	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413003193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
233413003194	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
233413003195	enoyl-CoA hydratase; Provisional; Region: PRK06688
233413003196	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413003197	substrate binding site [chemical binding]; other site
233413003198	trimer interface [polypeptide binding]; other site
233413003199	oxyanion hole (OAH) forming residues; other site
233413003200	enoyl-CoA hydratase; Provisional; Region: PRK06688
233413003201	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413003202	substrate binding site [chemical binding]; other site
233413003203	oxyanion hole (OAH) forming residues; other site
233413003204	trimer interface [polypeptide binding]; other site
233413003205	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
233413003206	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
233413003207	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
233413003208	NAD binding site [chemical binding]; other site
233413003209	homodimer interface [polypeptide binding]; other site
233413003210	homotetramer interface [polypeptide binding]; other site
233413003211	active site
233413003212	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
233413003213	MMPL family; Region: MMPL; cl14618
233413003214	MMPL family; Region: MMPL; cl14618
233413003215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413003216	S-adenosylmethionine binding site [chemical binding]; other site
233413003217	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413003218	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413003219	active site
233413003220	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
233413003221	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
233413003222	Mb1181, -, len: 183 aa. Equivalent to Rv1150, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 183 aa overlap). Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of  Mycobacterium tuberculosis IS element (308 aa), FASTA scores: opt: 959, E(): 0, (99.3% identity in 145 aa overlap). The transposase described here may be made by a -1 frame shifting mechanism during translation that fuses Rv1149|MTCI65.16 and Rv1150|MTCI65.17. No evidence found to account for discrepancy with previously published sequence. Second copy is Rv1041c|MTCY10G2.08. TBparse score is 0.914.;POSSIBLE TRANSPOSASE (FRAGMENT)
233413003223	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
233413003224	NAD+ binding site [chemical binding]; other site
233413003225	substrate binding site [chemical binding]; other site
233413003226	Zn binding site [ion binding]; other site
233413003227	Predicted transcriptional regulators [Transcription]; Region: COG1725
233413003228	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
233413003229	DNA-binding site [nucleotide binding]; DNA binding site
233413003230	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413003231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
233413003232	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
233413003233	uncharacterized HhH-GPD family protein; Region: TIGR03252
233413003234	minor groove reading motif; other site
233413003235	helix-hairpin-helix signature motif; other site
233413003236	Transcription factor IIA, alpha/beta subunit; Region: TFIIA; pfam03153
233413003237	mannosyltransferase; Provisional; Region: pimE; PRK13375
233413003238	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
233413003239	aromatic arch; other site
233413003240	DCoH dimer interaction site [polypeptide binding]; other site
233413003241	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
233413003242	DCoH tetramer interaction site [polypeptide binding]; other site
233413003243	substrate binding site [chemical binding]; other site
233413003244	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
233413003245	active site
233413003246	8-oxo-dGMP binding site [chemical binding]; other site
233413003247	nudix motif; other site
233413003248	metal binding site [ion binding]; metal-binding site
233413003249	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
233413003250	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
233413003251	[4Fe-4S] binding site [ion binding]; other site
233413003252	molybdopterin cofactor binding site [chemical binding]; other site
233413003253	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
233413003254	molybdopterin cofactor binding site; other site
233413003255	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
233413003256	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
233413003257	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
233413003258	nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684
233413003259	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
233413003260	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
233413003261	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
233413003262	G1 box; other site
233413003263	putative GEF interaction site [polypeptide binding]; other site
233413003264	GTP/Mg2+ binding site [chemical binding]; other site
233413003265	Switch I region; other site
233413003266	G2 box; other site
233413003267	G3 box; other site
233413003268	Switch II region; other site
233413003269	G4 box; other site
233413003270	G5 box; other site
233413003271	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
233413003272	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
233413003273	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
233413003274	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
233413003275	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413003276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413003277	Mb1200c, PPE17b, len: 181 aa. Equivalent to 3' end of Rv1168c, len: 346 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: opt: 504, E(): 0, (36.6% identity in 388 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b.;PPE FAMILY PROTEIN [SECOND PART]
233413003278	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413003279	PPE family; Region: PPE; pfam00823
233413003280	PE family; Region: PE; pfam00934
233413003281	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
233413003282	PE family; Region: PE; pfam00934
233413003283	FO synthase; Reviewed; Region: fbiC; PRK09234
233413003284	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413003285	FeS/SAM binding site; other site
233413003286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413003287	FeS/SAM binding site; other site
233413003288	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
233413003289	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
233413003290	active site
233413003291	FMN binding site [chemical binding]; other site
233413003292	2,4-decadienoyl-CoA binding site; other site
233413003293	catalytic residue [active]
233413003294	4Fe-4S cluster binding site [ion binding]; other site
233413003295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413003296	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413003297	Predicted transcriptional regulators [Transcription]; Region: COG1695
233413003298	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
233413003299	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
233413003300	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
233413003301	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
233413003302	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413003303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413003304	homodimer interface [polypeptide binding]; other site
233413003305	catalytic residue [active]
233413003306	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
233413003307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
233413003308	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413003309	ATP-binding site [chemical binding]; other site
233413003310	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413003311	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413003312	active site
233413003313	Acyl transferase domain; Region: Acyl_transf_1; cl08282
233413003314	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413003315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413003316	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413003317	Enoylreductase; Region: PKS_ER; smart00829
233413003318	NAD(P) binding site [chemical binding]; other site
233413003319	short chain dehydrogenase; Region: adh_short; pfam00106
233413003320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413003321	NAD(P) binding site [chemical binding]; other site
233413003322	active site
233413003323	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413003324	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
233413003325	Condensation domain; Region: Condensation; cl19241
233413003326	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413003327	MMPL family; Region: MMPL; pfam03176
233413003328	MMPL family; Region: MMPL; pfam03176
233413003329	PE-PPE domain; Region: PE-PPE; pfam08237
233413003330	acyl-CoA synthetase; Validated; Region: PRK05850
233413003331	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413003332	acyl-activating enzyme (AAE) consensus motif; other site
233413003333	active site
233413003334	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
233413003335	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
233413003336	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
233413003337	Glutamate binding site [chemical binding]; other site
233413003338	NAD binding site [chemical binding]; other site
233413003339	catalytic residues [active]
233413003340	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
233413003341	Proline dehydrogenase; Region: Pro_dh; pfam01619
233413003342	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
233413003343	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413003344	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
233413003345	DNA binding residues [nucleotide binding]
233413003346	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413003347	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
233413003348	catalytic site [active]
233413003349	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413003350	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413003351	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413003352	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413003353	PGAP1-like protein; Region: PGAP1; pfam07819
233413003354	acyl-CoA synthetase; Validated; Region: PRK07787
233413003355	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413003356	acyl-activating enzyme (AAE) consensus motif; other site
233413003357	AMP binding site [chemical binding]; other site
233413003358	active site
233413003359	CoA binding site [chemical binding]; other site
233413003360	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
233413003361	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
233413003362	PE family; Region: PE; pfam00934
233413003363	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413003364	PPE family; Region: PPE; pfam00823
233413003365	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413003366	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
233413003367	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
233413003368	Transposase, Mutator family; Region: Transposase_mut; pfam00872
233413003369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413003370	metabolite-proton symporter; Region: 2A0106; TIGR00883
233413003371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413003372	putative substrate translocation pore; other site
233413003373	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
233413003374	Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789
233413003375	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
233413003376	putative trimer interface [polypeptide binding]; other site
233413003377	putative CoA binding site [chemical binding]; other site
233413003378	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
233413003379	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
233413003380	metal binding site [ion binding]; metal-binding site
233413003381	putative dimer interface [polypeptide binding]; other site
233413003382	AAA ATPase domain; Region: AAA_16; pfam13191
233413003383	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
233413003384	TIGR00730 family protein; Region: TIGR00730
233413003385	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
233413003386	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
233413003387	acyl-activating enzyme (AAE) consensus motif; other site
233413003388	putative AMP binding site [chemical binding]; other site
233413003389	putative active site [active]
233413003390	putative CoA binding site [chemical binding]; other site
233413003391	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
233413003392	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
233413003393	substrate binding pocket [chemical binding]; other site
233413003394	dimer interface [polypeptide binding]; other site
233413003395	inhibitor binding site; inhibition site
233413003396	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
233413003397	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
233413003398	DivIVA domain; Region: DivI1A_domain; TIGR03544
233413003399	DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624
233413003400	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
233413003401	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
233413003402	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
233413003403	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
233413003404	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
233413003405	ligand binding site; other site
233413003406	oligomer interface; other site
233413003407	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
233413003408	dimer interface [polypeptide binding]; other site
233413003409	N-terminal domain interface [polypeptide binding]; other site
233413003410	sulfate 1 binding site; other site
233413003411	PE family; Region: PE; pfam00934
233413003412	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
233413003413	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413003414	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
233413003415	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
233413003416	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
233413003417	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
233413003418	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
233413003419	Walker A/P-loop; other site
233413003420	ATP binding site [chemical binding]; other site
233413003421	Q-loop/lid; other site
233413003422	ABC transporter signature motif; other site
233413003423	Walker B; other site
233413003424	D-loop; other site
233413003425	H-loop/switch region; other site
233413003426	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
233413003427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413003428	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413003429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413003430	S-adenosylmethionine binding site [chemical binding]; other site
233413003431	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
233413003432	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413003433	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413003434	DNA binding residues [nucleotide binding]
233413003435	chaperone protein DnaJ; Provisional; Region: PRK10767
233413003436	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
233413003437	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
233413003438	protein binding site [polypeptide binding]; other site
233413003439	sec-independent translocase; Provisional; Region: PRK03100
233413003440	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
233413003441	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
233413003442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413003443	Predicted membrane protein [Function unknown]; Region: COG3428
233413003444	Bacterial PH domain; Region: bPH_2; pfam03703
233413003445	Uncharacterized conserved protein [Function unknown]; Region: COG3402
233413003446	Domain of unknown function DUF59; Region: DUF59; cl00941
233413003447	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
233413003448	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
233413003449	Walker A motif; other site
233413003450	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
233413003451	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
233413003452	N-acetyl-D-glucosamine binding site [chemical binding]; other site
233413003453	catalytic residue [active]
233413003454	Predicted membrane protein [Function unknown]; Region: COG4420
233413003455	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
233413003456	MgtE intracellular N domain; Region: MgtE_N; smart00924
233413003457	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
233413003458	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
233413003459	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
233413003460	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
233413003461	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
233413003462	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
233413003463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413003464	dimer interface [polypeptide binding]; other site
233413003465	conserved gate region; other site
233413003466	putative PBP binding loops; other site
233413003467	ABC-ATPase subunit interface; other site
233413003468	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
233413003469	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413003470	dimer interface [polypeptide binding]; other site
233413003471	conserved gate region; other site
233413003472	putative PBP binding loops; other site
233413003473	ABC-ATPase subunit interface; other site
233413003474	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
233413003475	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
233413003476	Walker A/P-loop; other site
233413003477	ATP binding site [chemical binding]; other site
233413003478	Q-loop/lid; other site
233413003479	ABC transporter signature motif; other site
233413003480	Walker B; other site
233413003481	D-loop; other site
233413003482	H-loop/switch region; other site
233413003483	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
233413003484	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
233413003485	oligomer interface [polypeptide binding]; other site
233413003486	metal binding site [ion binding]; metal-binding site
233413003487	metal binding site [ion binding]; metal-binding site
233413003488	putative Cl binding site [ion binding]; other site
233413003489	basic sphincter; other site
233413003490	hydrophobic gate; other site
233413003491	periplasmic entrance; other site
233413003492	malate dehydrogenase; Provisional; Region: PRK05442
233413003493	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
233413003494	NAD(P) binding site [chemical binding]; other site
233413003495	dimer interface [polypeptide binding]; other site
233413003496	malate binding site [chemical binding]; other site
233413003497	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413003498	PE family; Region: PE; pfam00934
233413003499	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
233413003500	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
233413003501	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413003502	NAD(P) binding site [chemical binding]; other site
233413003503	active site
233413003504	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
233413003505	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
233413003506	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
233413003507	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
233413003508	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
233413003509	TPP-binding site [chemical binding]; other site
233413003510	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
233413003511	dimer interface [polypeptide binding]; other site
233413003512	PYR/PP interface [polypeptide binding]; other site
233413003513	TPP binding site [chemical binding]; other site
233413003514	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
233413003515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413003516	putative substrate translocation pore; other site
233413003517	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
233413003518	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
233413003519	RNase_H superfamily; Region: RNase_H_2; pfam13482
233413003520	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
233413003521	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413003522	ATP binding site [chemical binding]; other site
233413003523	putative Mg++ binding site [ion binding]; other site
233413003524	AAA domain; Region: AAA_12; pfam13087
233413003525	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
233413003526	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
233413003527	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
233413003528	ATP binding site [chemical binding]; other site
233413003529	Mg++ binding site [ion binding]; other site
233413003530	motif III; other site
233413003531	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413003532	nucleotide binding region [chemical binding]; other site
233413003533	ATP-binding site [chemical binding]; other site
233413003534	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
233413003535	putative RNA binding site [nucleotide binding]; other site
233413003536	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
233413003537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413003538	H+ Antiporter protein; Region: 2A0121; TIGR00900
233413003539	putative substrate translocation pore; other site
233413003540	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
233413003541	Fe-S cluster binding site [ion binding]; other site
233413003542	DNA binding site [nucleotide binding]
233413003543	active site
233413003544	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
233413003545	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413003546	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413003547	Domain of unknown function (DUF385); Region: DUF385; pfam04075
233413003548	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
233413003549	HIT family signature motif; other site
233413003550	catalytic residue [active]
233413003551	amidase; Provisional; Region: PRK12470
233413003552	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413003553	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cd07556
233413003554	nucleotidyl binding site; other site
233413003555	metal binding site [ion binding]; metal-binding site
233413003556	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413003557	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413003558	active site
233413003559	ATP binding site [chemical binding]; other site
233413003560	substrate binding site [chemical binding]; other site
233413003561	activation loop (A-loop); other site
233413003562	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413003563	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
233413003564	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
233413003565	DNA binding site [nucleotide binding]
233413003566	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413003567	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413003568	phosphopeptide binding site; other site
233413003569	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
233413003570	putative active site [active]
233413003571	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
233413003572	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
233413003573	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413003574	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
233413003575	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
233413003576	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
233413003577	Walker A/P-loop; other site
233413003578	ATP binding site [chemical binding]; other site
233413003579	Q-loop/lid; other site
233413003580	ABC transporter signature motif; other site
233413003581	Walker B; other site
233413003582	D-loop; other site
233413003583	H-loop/switch region; other site
233413003584	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
233413003585	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
233413003586	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413003587	Walker A/P-loop; other site
233413003588	ATP binding site [chemical binding]; other site
233413003589	Q-loop/lid; other site
233413003590	ABC transporter signature motif; other site
233413003591	Walker B; other site
233413003592	D-loop; other site
233413003593	H-loop/switch region; other site
233413003594	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
233413003595	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
233413003596	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413003597	catalytic core [active]
233413003598	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
233413003599	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
233413003600	active site
233413003601	metal binding site [ion binding]; metal-binding site
233413003602	DNA binding site [nucleotide binding]
233413003603	AAA domain; Region: AAA_23; pfam13476
233413003604	Walker A/P-loop; other site
233413003605	ATP binding site [chemical binding]; other site
233413003606	AAA domain; Region: AAA_27; pfam13514
233413003607	choline dehydrogenase; Validated; Region: PRK02106
233413003608	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
233413003609	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
233413003610	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
233413003611	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
233413003612	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
233413003613	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
233413003614	Walker A/P-loop; other site
233413003615	ATP binding site [chemical binding]; other site
233413003616	Q-loop/lid; other site
233413003617	ABC transporter signature motif; other site
233413003618	Walker B; other site
233413003619	D-loop; other site
233413003620	H-loop/switch region; other site
233413003621	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
233413003622	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
233413003623	Walker A/P-loop; other site
233413003624	ATP binding site [chemical binding]; other site
233413003625	Q-loop/lid; other site
233413003626	ABC transporter signature motif; other site
233413003627	Walker B; other site
233413003628	D-loop; other site
233413003629	H-loop/switch region; other site
233413003630	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
233413003631	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
233413003632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413003633	dimer interface [polypeptide binding]; other site
233413003634	conserved gate region; other site
233413003635	putative PBP binding loops; other site
233413003636	ABC-ATPase subunit interface; other site
233413003637	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
233413003638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413003639	dimer interface [polypeptide binding]; other site
233413003640	conserved gate region; other site
233413003641	putative PBP binding loops; other site
233413003642	ABC-ATPase subunit interface; other site
233413003643	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
233413003644	active site clefts [active]
233413003645	zinc binding site [ion binding]; other site
233413003646	dimer interface [polypeptide binding]; other site
233413003647	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
233413003648	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
233413003649	Active Sites [active]
233413003650	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
233413003651	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
233413003652	CysD dimerization site [polypeptide binding]; other site
233413003653	G1 box; other site
233413003654	putative GEF interaction site [polypeptide binding]; other site
233413003655	GTP/Mg2+ binding site [chemical binding]; other site
233413003656	Switch I region; other site
233413003657	G2 box; other site
233413003658	G3 box; other site
233413003659	Switch II region; other site
233413003660	G4 box; other site
233413003661	G5 box; other site
233413003662	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
233413003663	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
233413003664	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413003665	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
233413003666	Walker A/P-loop; other site
233413003667	ligand-binding site [chemical binding]; other site
233413003668	ATP binding site [chemical binding]; other site
233413003669	Predicted transcriptional regulator [Transcription]; Region: COG1959
233413003670	Rrf2 family protein; Region: rrf2_super; TIGR00738
233413003671	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
233413003672	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
233413003673	Putative esterase; Region: Esterase; pfam00756
233413003674	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
233413003675	Predicted membrane protein [Function unknown]; Region: COG4325
233413003676	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
233413003677	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413003678	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
233413003679	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
233413003680	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
233413003681	active site
233413003682	HIGH motif; other site
233413003683	KMSK motif region; other site
233413003684	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
233413003685	tRNA binding surface [nucleotide binding]; other site
233413003686	anticodon binding site; other site
233413003687	diaminopimelate decarboxylase; Region: lysA; TIGR01048
233413003688	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
233413003689	active site
233413003690	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
233413003691	substrate binding site [chemical binding]; other site
233413003692	catalytic residues [active]
233413003693	dimer interface [polypeptide binding]; other site
233413003694	homoserine dehydrogenase; Provisional; Region: PRK06349
233413003695	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
233413003696	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
233413003697	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
233413003698	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
233413003699	homodimer interface [polypeptide binding]; other site
233413003700	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413003701	catalytic residue [active]
233413003702	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
233413003703	transcription termination factor Rho; Provisional; Region: PRK12678
233413003704	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
233413003705	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
233413003706	RNA binding site [nucleotide binding]; other site
233413003707	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
233413003708	multimer interface [polypeptide binding]; other site
233413003709	Walker A motif; other site
233413003710	ATP binding site [chemical binding]; other site
233413003711	Walker B motif; other site
233413003712	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
233413003713	peptide chain release factor 1; Validated; Region: prfA; PRK00591
233413003714	This domain is found in peptide chain release factors; Region: PCRF; smart00937
233413003715	RF-1 domain; Region: RF-1; pfam00472
233413003716	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
233413003717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413003718	S-adenosylmethionine binding site [chemical binding]; other site
233413003719	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
233413003720	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
233413003721	Mg++ binding site [ion binding]; other site
233413003722	putative catalytic motif [active]
233413003723	substrate binding site [chemical binding]; other site
233413003724	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
233413003725	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
233413003726	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
233413003727	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
233413003728	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
233413003729	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
233413003730	ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210
233413003731	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
233413003732	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
233413003733	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
233413003734	beta subunit interaction interface [polypeptide binding]; other site
233413003735	Walker A motif; other site
233413003736	ATP binding site [chemical binding]; other site
233413003737	Walker B motif; other site
233413003738	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
233413003739	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
233413003740	core domain interface [polypeptide binding]; other site
233413003741	delta subunit interface [polypeptide binding]; other site
233413003742	epsilon subunit interface [polypeptide binding]; other site
233413003743	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
233413003744	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
233413003745	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
233413003746	alpha subunit interaction interface [polypeptide binding]; other site
233413003747	Walker A motif; other site
233413003748	ATP binding site [chemical binding]; other site
233413003749	Walker B motif; other site
233413003750	inhibitor binding site; inhibition site
233413003751	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
233413003752	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
233413003753	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
233413003754	gamma subunit interface [polypeptide binding]; other site
233413003755	epsilon subunit interface [polypeptide binding]; other site
233413003756	LBP interface [polypeptide binding]; other site
233413003757	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
233413003758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
233413003759	Transposase; Region: DDE_Tnp_ISL3; pfam01610
233413003760	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
233413003761	zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
233413003762	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
233413003763	Transposase; Region: DDE_Tnp_ISL3; pfam01610
233413003764	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
233413003765	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
233413003766	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
233413003767	hinge; other site
233413003768	active site
233413003769	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
233413003770	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
233413003771	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
233413003772	DNA binding site [nucleotide binding]
233413003773	active site
233413003774	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
233413003775	AlkA N-terminal domain; Region: AlkA_N; pfam06029
233413003776	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
233413003777	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
233413003778	minor groove reading motif; other site
233413003779	helix-hairpin-helix signature motif; other site
233413003780	substrate binding pocket [chemical binding]; other site
233413003781	active site
233413003782	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
233413003783	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
233413003784	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
233413003785	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413003786	dimerization interface [polypeptide binding]; other site
233413003787	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413003788	cyclase homology domain; Region: CHD; cd07302
233413003789	nucleotidyl binding site; other site
233413003790	metal binding site [ion binding]; metal-binding site
233413003791	dimer interface [polypeptide binding]; other site
233413003792	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
233413003793	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413003794	dimerization interface [polypeptide binding]; other site
233413003795	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413003796	cyclase homology domain; Region: CHD; cd07302
233413003797	nucleotidyl binding site; other site
233413003798	metal binding site [ion binding]; metal-binding site
233413003799	dimer interface [polypeptide binding]; other site
233413003800	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
233413003801	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413003802	dimerization interface [polypeptide binding]; other site
233413003803	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413003804	cyclase homology domain; Region: CHD; cd07302
233413003805	nucleotidyl binding site; other site
233413003806	metal binding site [ion binding]; metal-binding site
233413003807	dimer interface [polypeptide binding]; other site
233413003808	hypothetical protein; Provisional; Region: PRK03298
233413003809	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
233413003810	dimer interface [polypeptide binding]; other site
233413003811	substrate binding site [chemical binding]; other site
233413003812	metal binding site [ion binding]; metal-binding site
233413003813	putative acyltransferase; Provisional; Region: PRK05790
233413003814	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
233413003815	dimer interface [polypeptide binding]; other site
233413003816	active site
233413003817	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
233413003818	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
233413003819	Tetratricopeptide repeat; Region: TPR_20; pfam14561
233413003820	PE family; Region: PE; pfam00934
233413003821	glycogen branching enzyme; Provisional; Region: PRK05402
233413003822	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
233413003823	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
233413003824	active site
233413003825	catalytic site [active]
233413003826	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
233413003827	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
233413003828	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
233413003829	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
233413003830	active site
233413003831	homodimer interface [polypeptide binding]; other site
233413003832	catalytic site [active]
233413003833	acceptor binding site [chemical binding]; other site
233413003834	Glucan phosphorylase [Carbohydrate transport and metabolism]; Region: GlgP; COG0058
233413003835	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
233413003836	putative homodimer interface [polypeptide binding]; other site
233413003837	putative active site pocket [active]
233413003838	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
233413003839	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
233413003840	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708
233413003841	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
233413003842	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
233413003843	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
233413003844	active site
233413003845	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
233413003846	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
233413003847	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
233413003848	putative active site pocket [active]
233413003849	cleavage site
233413003850	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
233413003851	MPN+ (JAMM) motif; other site
233413003852	Zinc-binding site [ion binding]; other site
233413003853	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
233413003854	MoaE interaction surface [polypeptide binding]; other site
233413003855	MoeB interaction surface [polypeptide binding]; other site
233413003856	thiocarboxylated glycine; other site
233413003857	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
233413003858	dimer interface [polypeptide binding]; other site
233413003859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413003860	catalytic residue [active]
233413003861	Rhomboid family; Region: Rhomboid; pfam01694
233413003862	glutamate racemase; Provisional; Region: PRK00865
233413003863	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
233413003864	ribonuclease PH; Reviewed; Region: rph; PRK00173
233413003865	Ribonuclease PH; Region: RNase_PH_bact; cd11362
233413003866	hexamer interface [polypeptide binding]; other site
233413003867	active site
233413003868	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
233413003869	active site
233413003870	dimerization interface [polypeptide binding]; other site
233413003871	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
233413003872	Glucitol operon activator [Transcription]; Region: GutM; COG4578
233413003873	acyl carrier protein; Validated; Region: PRK05883
233413003874	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
233413003875	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413003876	acyl-activating enzyme (AAE) consensus motif; other site
233413003877	active site
233413003878	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413003879	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413003880	active site
233413003881	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
233413003882	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
233413003883	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
233413003884	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
233413003885	FAD binding pocket [chemical binding]; other site
233413003886	FAD binding motif [chemical binding]; other site
233413003887	phosphate binding motif [ion binding]; other site
233413003888	NAD binding pocket [chemical binding]; other site
233413003889	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
233413003890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413003891	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
233413003892	Walker A/P-loop; other site
233413003893	ATP binding site [chemical binding]; other site
233413003894	Q-loop/lid; other site
233413003895	ABC transporter signature motif; other site
233413003896	Walker B; other site
233413003897	D-loop; other site
233413003898	H-loop/switch region; other site
233413003899	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
233413003900	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413003901	Walker A/P-loop; other site
233413003902	ATP binding site [chemical binding]; other site
233413003903	Q-loop/lid; other site
233413003904	ABC transporter signature motif; other site
233413003905	Walker B; other site
233413003906	D-loop; other site
233413003907	H-loop/switch region; other site
233413003908	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
233413003909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413003910	NAD(P) binding site [chemical binding]; other site
233413003911	active site
233413003912	tetracycline repressor protein TetR; Provisional; Region: PRK13756
233413003913	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413003914	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
233413003915	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
233413003916	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
233413003917	metal binding site [ion binding]; metal-binding site
233413003918	active site
233413003919	I-site; other site
233413003920	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
233413003921	hypothetical protein; Provisional; Region: PRK07877
233413003922	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
233413003923	ATP binding site [chemical binding]; other site
233413003924	substrate interface [chemical binding]; other site
233413003925	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
233413003926	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
233413003927	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
233413003928	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413003929	cyclase homology domain; Region: CHD; cd07302
233413003930	nucleotidyl binding site; other site
233413003931	metal binding site [ion binding]; metal-binding site
233413003932	dimer interface [polypeptide binding]; other site
233413003933	Predicted ATPase [General function prediction only]; Region: COG3903
233413003934	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413003935	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413003936	DNA binding residues [nucleotide binding]
233413003937	dimerization interface [polypeptide binding]; other site
233413003938	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413003939	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
233413003940	metal binding site [ion binding]; metal-binding site
233413003941	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413003942	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413003943	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413003944	PPE family; Region: PPE; pfam00823
233413003945	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413003946	PAS domain S-box; Region: sensory_box; TIGR00229
233413003947	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
233413003948	putative active site [active]
233413003949	heme pocket [chemical binding]; other site
233413003950	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
233413003951	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
233413003952	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
233413003953	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
233413003954	anti sigma factor interaction site; other site
233413003955	regulatory phosphorylation site [posttranslational modification]; other site
233413003956	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
233413003957	anti sigma factor interaction site; other site
233413003958	regulatory phosphorylation site [posttranslational modification]; other site
233413003959	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
233413003960	synthetase active site [active]
233413003961	NTP binding site [chemical binding]; other site
233413003962	metal binding site [ion binding]; metal-binding site
233413003963	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413003964	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
233413003965	Mb1404, -, len: 317 aa. Similar to 5' end of Rv1371, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (90.9% identity in 166 aa overlap). Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052, (22.4% identity in 438 aa overlap); and Homo sapiens. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, Mb1404 and Mb1405, with the latter being the more likely product.;PROBABLE CONSERVED MEMBRANE PROTEIN
233413003966	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
233413003967	putative di-iron ligands [ion binding]; other site
233413003968	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
233413003969	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
233413003970	malonyl-CoA binding site [chemical binding]; other site
233413003971	dimer interface [polypeptide binding]; other site
233413003972	active site
233413003973	product binding site; other site
233413003974	Sulfotransferase domain; Region: Sulfotransfer_1; cl19239
233413003975	Mb1408, -, len: 172 aa. Equivalent to the 3' end of Rv1373, len: 326 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 172 aa overlap). Glycolipid sulfotransferase (EC 2.8.2.-) (see citation below); slight similarity to sulfotransferases e.g. SUOE_CAVPO|P49887 estrogen sulfotransferase from Cavia porcellus (Guinea pig) (EC 2.8.2.4) (296 aa), FASTA scores, opt: 165, E():0.00054, (24.5% identity in 294 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408.;GLYCOLIPID SULFOTRANSFERASE [SECOND PART]
233413003976	uncharacterized domain; Region: TIGR00702
233413003977	Uncharacterized conserved protein [Function unknown]; Region: COG3482
233413003978	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413003979	S-adenosylmethionine binding site [chemical binding]; other site
233413003980	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413003981	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413003982	active site
233413003983	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413003984	active site
233413003985	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
233413003986	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
233413003987	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
233413003988	dihydroorotase; Validated; Region: pyrC; PRK09357
233413003989	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
233413003990	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
233413003991	active site
233413003992	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
233413003993	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
233413003994	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
233413003995	catalytic site [active]
233413003996	subunit interface [polypeptide binding]; other site
233413003997	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
233413003998	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
233413003999	ATP-grasp domain; Region: ATP-grasp_4; cl17255
233413004000	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
233413004001	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
233413004002	ATP-grasp domain; Region: ATP-grasp_4; cl17255
233413004003	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
233413004004	IMP binding site; other site
233413004005	dimer interface [polypeptide binding]; other site
233413004006	interdomain contacts; other site
233413004007	partial ornithine binding site; other site
233413004008	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
233413004009	active site
233413004010	dimer interface [polypeptide binding]; other site
233413004011	PE family; Region: PE; pfam00934
233413004012	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413004013	PPE family; Region: PPE; pfam00823
233413004014	Guanylate kinase; Region: Guanylate_kin; pfam00625
233413004015	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
233413004016	catalytic site [active]
233413004017	G-X2-G-X-G-K; other site
233413004018	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
233413004019	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
233413004020	Flavoprotein; Region: Flavoprotein; cl19190
233413004021	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
233413004022	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
233413004023	S-adenosylmethionine synthetase; Validated; Region: PRK05250
233413004024	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
233413004025	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
233413004026	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413004027	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
233413004028	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413004029	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
233413004030	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
233413004031	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
233413004032	PE family; Region: PE; pfam00934
233413004033	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
233413004034	oligomeric interface; other site
233413004035	putative active site [active]
233413004036	homodimer interface [polypeptide binding]; other site
233413004037	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413004038	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413004039	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413004040	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413004041	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413004042	Predicted membrane protein [Function unknown]; Region: COG3714
233413004043	primosome assembly protein PriA; Provisional; Region: PRK14873
233413004044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413004045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004046	S-adenosylmethionine binding site [chemical binding]; other site
233413004047	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413004048	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
233413004049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004050	S-adenosylmethionine binding site [chemical binding]; other site
233413004051	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
233413004052	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
233413004053	putative active site [active]
233413004054	substrate binding site [chemical binding]; other site
233413004055	putative cosubstrate binding site; other site
233413004056	catalytic site [active]
233413004057	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
233413004058	substrate binding site [chemical binding]; other site
233413004059	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
233413004060	putative RNA binding site [nucleotide binding]; other site
233413004061	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
233413004062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004063	S-adenosylmethionine binding site [chemical binding]; other site
233413004064	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
233413004065	substrate binding site [chemical binding]; other site
233413004066	hexamer interface [polypeptide binding]; other site
233413004067	metal binding site [ion binding]; metal-binding site
233413004068	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
233413004069	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
233413004070	catalytic motif [active]
233413004071	Zn binding site [ion binding]; other site
233413004072	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
233413004073	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413004074	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
233413004075	putative substrate translocation pore; other site
233413004076	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
233413004077	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
233413004078	Lumazine binding domain; Region: Lum_binding; pfam00677
233413004079	Lumazine binding domain; Region: Lum_binding; pfam00677
233413004080	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
233413004081	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
233413004082	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
233413004083	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
233413004084	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
233413004085	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
233413004086	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
233413004087	dimerization interface [polypeptide binding]; other site
233413004088	active site
233413004089	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
233413004090	homopentamer interface [polypeptide binding]; other site
233413004091	active site
233413004092	Bacterial PH domain; Region: bPH_6; pfam10756
233413004093	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413004094	Ricin-type beta-trefoil; Region: RICIN; smart00458
233413004095	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
233413004096	putative sugar binding sites [chemical binding]; other site
233413004097	Q-X-W motif; other site
233413004098	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
233413004099	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
233413004100	GIY-YIG motif/motif A; other site
233413004101	active site
233413004102	catalytic site [active]
233413004103	putative DNA binding site [nucleotide binding]; other site
233413004104	metal binding site [ion binding]; metal-binding site
233413004105	UvrB/uvrC motif; Region: UVR; pfam02151
233413004106	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
233413004107	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
233413004108	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
233413004109	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
233413004110	phosphate binding site [ion binding]; other site
233413004111	putative substrate binding pocket [chemical binding]; other site
233413004112	dimer interface [polypeptide binding]; other site
233413004113	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
233413004114	WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298
233413004115	WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527
233413004116	WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650
233413004117	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413004118	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413004119	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413004120	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413004121	acyl-CoA synthetase; Provisional; Region: PRK13382
233413004122	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
233413004123	acyl-activating enzyme (AAE) consensus motif; other site
233413004124	putative AMP binding site [chemical binding]; other site
233413004125	putative active site [active]
233413004126	putative CoA binding site [chemical binding]; other site
233413004127	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
233413004128	putative acyl-acceptor binding pocket; other site
233413004129	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
233413004130	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
233413004131	PE family; Region: PE; pfam00934
233413004132	PE-PPE domain; Region: PE-PPE; pfam08237
233413004133	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
233413004134	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
233413004135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413004136	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
233413004137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
233413004138	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
233413004139	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
233413004140	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
233413004141	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
233413004142	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
233413004143	substrate binding site [chemical binding]; other site
233413004144	hinge regions; other site
233413004145	ADP binding site [chemical binding]; other site
233413004146	catalytic site [active]
233413004147	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
233413004148	substrate binding site [chemical binding]; other site
233413004149	dimer interface [polypeptide binding]; other site
233413004150	catalytic triad [active]
233413004151	SnoaL-like domain; Region: SnoaL_2; pfam12680
233413004152	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
233413004153	PE family; Region: PE; pfam00934
233413004154	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
233413004155	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
233413004156	molybdopterin cofactor binding site [chemical binding]; other site
233413004157	substrate binding site [chemical binding]; other site
233413004158	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
233413004159	molybdopterin cofactor binding site; other site
233413004160	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
233413004161	hydrophobic ligand binding site; other site
233413004162	Proteins of 100 residues with WXG; Region: WXG100; cl02005
233413004163	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
233413004164	putative active site [active]
233413004165	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
233413004166	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
233413004167	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
233413004168	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
233413004169	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
233413004170	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
233413004171	putative active site [active]
233413004172	catalytic residue [active]
233413004173	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
233413004174	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
233413004175	TPP-binding site [chemical binding]; other site
233413004176	dimer interface [polypeptide binding]; other site
233413004177	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
233413004178	PYR/PP interface [polypeptide binding]; other site
233413004179	dimer interface [polypeptide binding]; other site
233413004180	TPP binding site [chemical binding]; other site
233413004181	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
233413004182	PE family; Region: PE; pfam00934
233413004183	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
233413004184	putative active site [active]
233413004185	PE family; Region: PE; pfam00934
233413004186	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
233413004187	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
233413004188	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
233413004189	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
233413004190	NADP binding site [chemical binding]; other site
233413004191	dimer interface [polypeptide binding]; other site
233413004192	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
233413004193	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
233413004194	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
233413004195	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
233413004196	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
233413004197	Walker A/P-loop; other site
233413004198	ATP binding site [chemical binding]; other site
233413004199	Q-loop/lid; other site
233413004200	ABC transporter signature motif; other site
233413004201	Walker B; other site
233413004202	D-loop; other site
233413004203	H-loop/switch region; other site
233413004204	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
233413004205	Predicted transcriptional regulator [Transcription]; Region: COG2345
233413004206	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413004207	putative DNA binding site [nucleotide binding]; other site
233413004208	putative Zn2+ binding site [ion binding]; other site
233413004209	Transcriptional regulator PadR-like family; Region: PadR; cl17335
233413004210	Uncharacterized protein family (UPF0051); Region: UPF0051; cl19515
233413004211	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
233413004212	protein-splicing catalytic site; other site
233413004213	thioester formation/cholesterol transfer; other site
233413004214	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
233413004215	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
233413004216	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
233413004217	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
233413004218	protein-splicing catalytic site; other site
233413004219	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
233413004220	FeS assembly protein SufD; Region: sufD; TIGR01981
233413004221	FeS assembly ATPase SufC; Region: sufC; TIGR01978
233413004222	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
233413004223	Walker A/P-loop; other site
233413004224	ATP binding site [chemical binding]; other site
233413004225	Q-loop/lid; other site
233413004226	ABC transporter signature motif; other site
233413004227	Walker B; other site
233413004228	D-loop; other site
233413004229	H-loop/switch region; other site
233413004230	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
233413004231	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413004232	catalytic residue [active]
233413004233	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
233413004234	trimerization site [polypeptide binding]; other site
233413004235	active site
233413004236	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
233413004237	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
233413004238	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
233413004239	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413004240	active site
233413004241	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
233413004242	PE family; Region: PE; pfam00934
233413004243	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
233413004244	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413004245	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
233413004246	catalytic residues [active]
233413004247	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
233413004248	catalytic residues [active]
233413004249	enoyl-CoA hydratase; Provisional; Region: PRK05864
233413004250	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413004251	substrate binding site [chemical binding]; other site
233413004252	oxyanion hole (OAH) forming residues; other site
233413004253	trimer interface [polypeptide binding]; other site
233413004254	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
233413004255	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
233413004256	ABC transporter; Region: ABC_tran_2; pfam12848
233413004257	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
233413004258	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413004259	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413004260	aconitate hydratase; Validated; Region: PRK09277
233413004261	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
233413004262	substrate binding site [chemical binding]; other site
233413004263	ligand binding site [chemical binding]; other site
233413004264	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
233413004265	substrate binding site [chemical binding]; other site
233413004266	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
233413004267	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
233413004268	NlpC/P60 family; Region: NLPC_P60; pfam00877
233413004269	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
233413004270	NlpC/P60 family; Region: NLPC_P60; pfam00877
233413004271	MoxR-like ATPases [General function prediction only]; Region: COG0714
233413004272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413004273	Walker A motif; other site
233413004274	ATP binding site [chemical binding]; other site
233413004275	Walker B motif; other site
233413004276	arginine finger; other site
233413004277	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
233413004278	Protein of unknown function DUF58; Region: DUF58; pfam01882
233413004279	hypothetical protein; Provisional; Region: PRK13685
233413004280	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
233413004281	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
233413004282	metal ion-dependent adhesion site (MIDAS); other site
233413004283	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
233413004284	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
233413004285	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
233413004286	NAD(P) binding site [chemical binding]; other site
233413004287	homotetramer interface [polypeptide binding]; other site
233413004288	homodimer interface [polypeptide binding]; other site
233413004289	active site
233413004290	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
233413004291	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
233413004292	NAD binding site [chemical binding]; other site
233413004293	homotetramer interface [polypeptide binding]; other site
233413004294	homodimer interface [polypeptide binding]; other site
233413004295	substrate binding site [chemical binding]; other site
233413004296	active site
233413004297	ferrochelatase; Reviewed; Region: hemH; PRK00035
233413004298	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
233413004299	C-terminal domain interface [polypeptide binding]; other site
233413004300	active site
233413004301	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
233413004302	active site
233413004303	N-terminal domain interface [polypeptide binding]; other site
233413004304	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
233413004305	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
233413004306	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
233413004307	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
233413004308	DoxX-like family; Region: DoxX_2; pfam13564
233413004309	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
233413004310	Uncharacterized conserved protein [Function unknown]; Region: COG0398
233413004311	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
233413004312	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
233413004313	heterodimer interface [polypeptide binding]; other site
233413004314	substrate interaction site [chemical binding]; other site
233413004315	Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
233413004316	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
233413004317	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
233413004318	active site
233413004319	substrate binding site [chemical binding]; other site
233413004320	coenzyme B12 binding site [chemical binding]; other site
233413004321	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
233413004322	B12 binding site [chemical binding]; other site
233413004323	cobalt ligand [ion binding]; other site
233413004324	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
233413004325	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
233413004326	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
233413004327	Walker A; other site
233413004328	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
233413004329	G4 box; other site
233413004330	G5 box; other site
233413004331	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413004332	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413004333	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004334	S-adenosylmethionine binding site [chemical binding]; other site
233413004335	Dodecin; Region: Dodecin; pfam07311
233413004336	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
233413004337	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
233413004338	Ligand binding site; other site
233413004339	Putative Catalytic site; other site
233413004340	DXD motif; other site
233413004341	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
233413004342	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
233413004343	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
233413004344	inhibitor-cofactor binding pocket; inhibition site
233413004345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413004346	catalytic residue [active]
233413004347	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
233413004348	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
233413004349	putative trimer interface [polypeptide binding]; other site
233413004350	putative CoA binding site [chemical binding]; other site
233413004351	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
233413004352	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
233413004353	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
233413004354	active site
233413004355	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
233413004356	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
233413004357	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
233413004358	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
233413004359	active site
233413004360	acyl-CoA synthetase; Validated; Region: PRK05850
233413004361	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413004362	acyl-activating enzyme (AAE) consensus motif; other site
233413004363	active site
233413004364	Transport protein; Region: actII; TIGR00833
233413004365	MMPL family; Region: MMPL; pfam03176
233413004366	MMPL family; Region: MMPL; pfam03176
233413004367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004368	S-adenosylmethionine binding site [chemical binding]; other site
233413004369	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
233413004370	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
233413004371	homodimer interface [polypeptide binding]; other site
233413004372	active site
233413004373	TDP-binding site; other site
233413004374	acceptor substrate-binding pocket; other site
233413004375	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
233413004376	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
233413004377	Probable Catalytic site; other site
233413004378	metal-binding site
233413004379	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
233413004380	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
233413004381	homodimer interface [polypeptide binding]; other site
233413004382	active site
233413004383	TDP-binding site; other site
233413004384	acceptor substrate-binding pocket; other site
233413004385	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413004386	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413004387	active site
233413004388	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
233413004389	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413004390	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413004391	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413004392	Enoylreductase; Region: PKS_ER; smart00829
233413004393	NAD(P) binding site [chemical binding]; other site
233413004394	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413004395	short chain dehydrogenase; Region: adh_short; pfam00106
233413004396	NAD(P) binding site [chemical binding]; other site
233413004397	active site
233413004398	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413004399	acyl-CoA synthetase; Validated; Region: PRK05850
233413004400	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413004401	acyl-activating enzyme (AAE) consensus motif; other site
233413004402	active site
233413004403	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
233413004404	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
233413004405	NAD(P) binding site [chemical binding]; other site
233413004406	Uncharacterized conserved protein [Function unknown]; Region: COG2128
233413004407	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
233413004408	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
233413004409	CoenzymeA binding site [chemical binding]; other site
233413004410	subunit interaction site [polypeptide binding]; other site
233413004411	PHB binding site; other site
233413004412	Nitronate monooxygenase; Region: NMO; pfam03060
233413004413	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
233413004414	FMN binding site [chemical binding]; other site
233413004415	substrate binding site [chemical binding]; other site
233413004416	putative catalytic residue [active]
233413004417	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413004418	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413004419	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
233413004420	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
233413004421	active site
233413004422	HIGH motif; other site
233413004423	nucleotide binding site [chemical binding]; other site
233413004424	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
233413004425	active site
233413004426	KMSKS motif; other site
233413004427	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
233413004428	tRNA binding surface [nucleotide binding]; other site
233413004429	anticodon binding site; other site
233413004430	DNA polymerase IV; Provisional; Region: PRK03348
233413004431	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
233413004432	active site
233413004433	DNA binding site [nucleotide binding]
233413004434	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
233413004435	active site
233413004436	homodimer interface [polypeptide binding]; other site
233413004437	homotetramer interface [polypeptide binding]; other site
233413004438	lipoprotein signal peptidase; Provisional; Region: PRK14764
233413004439	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
233413004440	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
233413004441	active site
233413004442	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
233413004443	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
233413004444	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
233413004445	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
233413004446	apolar tunnel; other site
233413004447	heme binding site [chemical binding]; other site
233413004448	dimerization interface [polypeptide binding]; other site
233413004449	short chain dehydrogenase; Provisional; Region: PRK05866
233413004450	classical (c) SDRs; Region: SDR_c; cd05233
233413004451	NAD(P) binding site [chemical binding]; other site
233413004452	active site
233413004453	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
233413004454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413004455	NAD(P) binding site [chemical binding]; other site
233413004456	active site
233413004457	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
233413004458	hydrophobic ligand binding site; other site
233413004459	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
233413004460	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
233413004461	active site
233413004462	PHP Thumb interface [polypeptide binding]; other site
233413004463	metal binding site [ion binding]; metal-binding site
233413004464	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
233413004465	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
233413004466	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
233413004467	generic binding surface II; other site
233413004468	generic binding surface I; other site
233413004469	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413004470	PPE family; Region: PPE; pfam00823
233413004471	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413004472	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413004473	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413004474	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413004475	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413004476	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413004477	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
233413004478	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
233413004479	acyl-activating enzyme (AAE) consensus motif; other site
233413004480	putative AMP binding site [chemical binding]; other site
233413004481	putative active site [active]
233413004482	putative CoA binding site [chemical binding]; other site
233413004483	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
233413004484	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
233413004485	putative acyl-acceptor binding pocket; other site
233413004486	fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176
233413004487	L-aspartate oxidase; Provisional; Region: PRK06175
233413004488	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
233413004489	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
233413004490	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
233413004491	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
233413004492	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
233413004493	D-subunit interface [polypeptide binding]; other site
233413004494	Iron-sulfur protein interface; other site
233413004495	proximal quinone binding site [chemical binding]; other site
233413004496	distal quinone binding site [chemical binding]; other site
233413004497	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
233413004498	Iron-sulfur protein interface; other site
233413004499	proximal quinone binding site [chemical binding]; other site
233413004500	C-subunit interface; other site
233413004501	distal quinone binding site; other site
233413004502	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413004503	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413004504	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
233413004505	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413004506	MMPL family; Region: MMPL; pfam03176
233413004507	MMPL family; Region: MMPL; pfam03176
233413004508	Domain of unknown function (DUF385); Region: DUF385; pfam04075
233413004509	threonine dehydratase; Validated; Region: PRK08639
233413004510	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
233413004511	tetramer interface [polypeptide binding]; other site
233413004512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413004513	catalytic residue [active]
233413004514	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
233413004515	putative Ile/Val binding site [chemical binding]; other site
233413004516	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
233413004517	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
233413004518	putative active site [active]
233413004519	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
233413004520	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
233413004521	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
233413004522	catalytic site [active]
233413004523	active site
233413004524	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
233413004525	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
233413004526	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
233413004527	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
233413004528	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
233413004529	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
233413004530	active site
233413004531	catalytic site [active]
233413004532	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
233413004533	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
233413004534	NlpC/P60 family; Region: NLPC_P60; pfam00877
233413004535	hypothetical protein; Provisional; Region: PHA03160
233413004536	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
233413004537	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
233413004538	inhibitor-cofactor binding pocket; inhibition site
233413004539	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413004540	catalytic residue [active]
233413004541	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
233413004542	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
233413004543	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413004544	catalytic residue [active]
233413004545	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413004546	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
233413004547	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
233413004548	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
233413004549	Phage head maturation protease [General function prediction only]; Region: COG3740
233413004550	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: COG3747
233413004551	Phage associated DNA primase [General function prediction only]; Region: COG3378
233413004552	D5 N terminal like; Region: D5_N; smart00885
233413004553	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
233413004554	Protein of unknown function (DUF2742); Region: DUF2742; pfam10888
233413004555	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
233413004556	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
233413004557	catalytic residues [active]
233413004558	catalytic nucleophile [active]
233413004559	Recombinase; Region: Recombinase; pfam07508
233413004560	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
233413004561	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413004562	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413004563	active site
233413004564	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413004565	biotin synthase; Validated; Region: PRK06256
233413004566	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413004567	FeS/SAM binding site; other site
233413004568	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
233413004569	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
233413004570	Secretory lipase; Region: LIP; pfam03583
233413004571	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
233413004572	nudix motif; other site
233413004573	quinolinate synthetase; Provisional; Region: PRK09375
233413004574	L-aspartate oxidase; Provisional; Region: PRK07804
233413004575	L-aspartate oxidase; Provisional; Region: PRK06175
233413004576	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
233413004577	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
233413004578	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
233413004579	dimerization interface [polypeptide binding]; other site
233413004580	active site
233413004581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004582	S-adenosylmethionine binding site [chemical binding]; other site
233413004583	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
233413004584	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
233413004585	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
233413004586	NAD binding site [chemical binding]; other site
233413004587	dimerization interface [polypeptide binding]; other site
233413004588	product binding site; other site
233413004589	substrate binding site [chemical binding]; other site
233413004590	zinc binding site [ion binding]; other site
233413004591	catalytic residues [active]
233413004592	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
233413004593	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413004594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413004595	homodimer interface [polypeptide binding]; other site
233413004596	catalytic residue [active]
233413004597	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
233413004598	putative active site pocket [active]
233413004599	4-fold oligomerization interface [polypeptide binding]; other site
233413004600	metal binding residues [ion binding]; metal-binding site
233413004601	3-fold/trimer interface [polypeptide binding]; other site
233413004602	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
233413004603	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
233413004604	putative active site [active]
233413004605	oxyanion strand; other site
233413004606	catalytic triad [active]
233413004607	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
233413004608	catalytic residues [active]
233413004609	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
233413004610	active site
233413004611	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
233413004612	substrate binding site [chemical binding]; other site
233413004613	glutamase interaction surface [polypeptide binding]; other site
233413004614	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
233413004615	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
233413004616	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
233413004617	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
233413004618	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
233413004619	catalytic triad [active]
233413004620	anthranilate synthase component I; Provisional; Region: PRK13571
233413004621	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
233413004622	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
233413004623	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
233413004624	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
233413004625	active site
233413004626	ribulose/triose binding site [chemical binding]; other site
233413004627	phosphate binding site [ion binding]; other site
233413004628	substrate (anthranilate) binding pocket [chemical binding]; other site
233413004629	product (indole) binding pocket [chemical binding]; other site
233413004630	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
233413004631	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413004632	catalytic residue [active]
233413004633	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
233413004634	substrate binding site [chemical binding]; other site
233413004635	active site
233413004636	catalytic residues [active]
233413004637	heterodimer interface [polypeptide binding]; other site
233413004638	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
233413004639	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
233413004640	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
233413004641	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
233413004642	pyruvate kinase; Provisional; Region: PRK06247
233413004643	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
233413004644	domain interfaces; other site
233413004645	active site
233413004646	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
233413004647	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
233413004648	active site
233413004649	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
233413004650	catalytic triad [active]
233413004651	dimer interface [polypeptide binding]; other site
233413004652	Uncharacterized conserved protein [Function unknown]; Region: COG2898
233413004653	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
233413004654	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
233413004655	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
233413004656	Walker A/P-loop; other site
233413004657	ATP binding site [chemical binding]; other site
233413004658	Q-loop/lid; other site
233413004659	ABC transporter signature motif; other site
233413004660	Walker B; other site
233413004661	D-loop; other site
233413004662	H-loop/switch region; other site
233413004663	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
233413004664	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
233413004665	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
233413004666	Walker A/P-loop; other site
233413004667	ATP binding site [chemical binding]; other site
233413004668	Q-loop/lid; other site
233413004669	ABC transporter signature motif; other site
233413004670	Walker B; other site
233413004671	D-loop; other site
233413004672	H-loop/switch region; other site
233413004673	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
233413004674	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
233413004675	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
233413004676	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
233413004677	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
233413004678	cyclase homology domain; Region: CHD; cd07302
233413004679	nucleotidyl binding site; other site
233413004680	metal binding site [ion binding]; metal-binding site
233413004681	dimer interface [polypeptide binding]; other site
233413004682	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
233413004683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413004684	active site
233413004685	phosphorylation site [posttranslational modification]
233413004686	intermolecular recognition site; other site
233413004687	dimerization interface [polypeptide binding]; other site
233413004688	ANTAR domain; Region: ANTAR; pfam03861
233413004689	lipid-transfer protein; Provisional; Region: PRK06059
233413004690	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
233413004691	active site
233413004692	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
233413004693	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
233413004694	DUF35 OB-fold domain; Region: DUF35; pfam01796
233413004695	DNA polymerase I; Provisional; Region: PRK05755
233413004696	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
233413004697	active site
233413004698	metal binding site 1 [ion binding]; metal-binding site
233413004699	putative 5' ssDNA interaction site; other site
233413004700	metal binding site 3; metal-binding site
233413004701	metal binding site 2 [ion binding]; metal-binding site
233413004702	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
233413004703	putative DNA binding site [nucleotide binding]; other site
233413004704	putative metal binding site [ion binding]; other site
233413004705	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
233413004706	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
233413004707	active site
233413004708	DNA binding site [nucleotide binding]
233413004709	catalytic site [active]
233413004710	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
233413004711	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
233413004712	RNA binding site [nucleotide binding]; other site
233413004713	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
233413004714	RNA binding site [nucleotide binding]; other site
233413004715	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
233413004716	RNA binding site [nucleotide binding]; other site
233413004717	S1 RNA binding domain; Region: S1; pfam00575
233413004718	RNA binding site [nucleotide binding]; other site
233413004719	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
233413004720	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
233413004721	CoA-binding site [chemical binding]; other site
233413004722	ATP-binding [chemical binding]; other site
233413004723	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
233413004724	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
233413004725	excinuclease ABC subunit B; Provisional; Region: PRK05298
233413004726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413004727	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413004728	Walker A/P-loop; other site
233413004729	ATP binding site [chemical binding]; other site
233413004730	ATP binding site [chemical binding]; other site
233413004731	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413004732	nucleotide binding region [chemical binding]; other site
233413004733	ATP-binding site [chemical binding]; other site
233413004734	Ultra-violet resistance protein B; Region: UvrB; pfam12344
233413004735	UvrB/uvrC motif; Region: UVR; pfam02151
233413004736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413004737	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413004738	putative substrate translocation pore; other site
233413004739	Predicted membrane protein [Function unknown]; Region: COG5305
233413004740	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413004741	Ligand Binding Site [chemical binding]; other site
233413004742	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
233413004743	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
233413004744	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
233413004745	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
233413004746	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
233413004747	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
233413004748	Predicted esterase [General function prediction only]; Region: COG0627
233413004749	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
233413004750	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
233413004751	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
233413004752	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
233413004753	dimer interface [polypeptide binding]; other site
233413004754	putative anticodon binding site; other site
233413004755	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
233413004756	motif 1; other site
233413004757	dimer interface [polypeptide binding]; other site
233413004758	active site
233413004759	motif 2; other site
233413004760	motif 3; other site
233413004761	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
233413004762	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
233413004763	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
233413004764	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
233413004765	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
233413004766	23S rRNA binding site [nucleotide binding]; other site
233413004767	L21 binding site [polypeptide binding]; other site
233413004768	L13 binding site [polypeptide binding]; other site
233413004769	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
233413004770	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
233413004771	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
233413004772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
233413004773	PE family; Region: PE; pfam00934
233413004774	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413004775	cyclase homology domain; Region: CHD; cd07302
233413004776	nucleotidyl binding site; other site
233413004777	metal binding site [ion binding]; metal-binding site
233413004778	dimer interface [polypeptide binding]; other site
233413004779	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
233413004780	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
233413004781	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
233413004782	dimer interface [polypeptide binding]; other site
233413004783	motif 1; other site
233413004784	active site
233413004785	motif 2; other site
233413004786	motif 3; other site
233413004787	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
233413004788	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
233413004789	putative tRNA-binding site [nucleotide binding]; other site
233413004790	B3/4 domain; Region: B3_4; pfam03483
233413004791	tRNA synthetase B5 domain; Region: B5; smart00874
233413004792	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
233413004793	dimer interface [polypeptide binding]; other site
233413004794	motif 1; other site
233413004795	motif 3; other site
233413004796	motif 2; other site
233413004797	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
233413004798	PE family; Region: PE; pfam00934
233413004799	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
233413004800	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
233413004801	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
233413004802	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
233413004803	heterotetramer interface [polypeptide binding]; other site
233413004804	active site pocket [active]
233413004805	cleavage site
233413004806	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
233413004807	feedback inhibition sensing region; other site
233413004808	homohexameric interface [polypeptide binding]; other site
233413004809	nucleotide binding site [chemical binding]; other site
233413004810	N-acetyl-L-glutamate binding site [chemical binding]; other site
233413004811	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
233413004812	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
233413004813	inhibitor-cofactor binding pocket; inhibition site
233413004814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413004815	catalytic residue [active]
233413004816	ornithine carbamoyltransferase; Provisional; Region: PRK00779
233413004817	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
233413004818	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
233413004819	arginine repressor; Provisional; Region: PRK03341
233413004820	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
233413004821	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
233413004822	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
233413004823	ANP binding site [chemical binding]; other site
233413004824	Substrate Binding Site II [chemical binding]; other site
233413004825	Substrate Binding Site I [chemical binding]; other site
233413004826	argininosuccinate lyase; Region: argH; TIGR00838
233413004827	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
233413004828	active sites [active]
233413004829	tetramer interface [polypeptide binding]; other site
233413004830	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
233413004831	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
233413004832	malonyl-CoA binding site [chemical binding]; other site
233413004833	dimer interface [polypeptide binding]; other site
233413004834	active site
233413004835	product binding site; other site
233413004836	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413004837	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413004838	active site
233413004839	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413004840	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413004841	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413004842	Enoylreductase; Region: PKS_ER; smart00829
233413004843	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413004844	NAD(P) binding site [chemical binding]; other site
233413004845	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
233413004846	short chain dehydrogenase; Region: adh_short; pfam00106
233413004847	putative NADP binding site [chemical binding]; other site
233413004848	active site
233413004849	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413004850	Erythronolide synthase docking; Region: Docking; pfam08990
233413004851	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413004852	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413004853	active site
233413004854	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413004855	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413004856	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413004857	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413004858	Enoylreductase; Region: PKS_ER; smart00829
233413004859	NAD(P) binding site [chemical binding]; other site
233413004860	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
233413004861	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
233413004862	short chain dehydrogenase; Region: adh_short; pfam00106
233413004863	putative NADP binding site [chemical binding]; other site
233413004864	active site
233413004865	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413004866	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
233413004867	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413004868	active site
233413004869	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413004870	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413004871	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
233413004872	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
233413004873	malonyl-CoA binding site [chemical binding]; other site
233413004874	dimer interface [polypeptide binding]; other site
233413004875	active site
233413004876	product binding site; other site
233413004877	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413004878	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
233413004879	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
233413004880	ABC transporter; Region: ABC_tran_2; pfam12848
233413004881	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
233413004882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
233413004883	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
233413004884	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413004885	putative substrate translocation pore; other site
233413004886	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
233413004887	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
233413004888	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413004889	dimerization interface [polypeptide binding]; other site
233413004890	putative DNA binding site [nucleotide binding]; other site
233413004891	putative Zn2+ binding site [ion binding]; other site
233413004892	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
233413004893	active site residue [active]
233413004894	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413004895	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413004896	ligand binding site [chemical binding]; other site
233413004897	flexible hinge region; other site
233413004898	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
233413004899	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
233413004900	putative catalytic residues [active]
233413004901	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
233413004902	catalytic residues [active]
233413004903	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413004904	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
233413004905	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
233413004906	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
233413004907	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
233413004908	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
233413004909	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413004910	FeS/SAM binding site; other site
233413004911	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
233413004912	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
233413004913	acyl-CoA synthetase; Validated; Region: PRK07868
233413004914	PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415
233413004915	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413004916	acyl-activating enzyme (AAE) consensus motif; other site
233413004917	AMP binding site [chemical binding]; other site
233413004918	active site
233413004919	CoA binding site [chemical binding]; other site
233413004920	Uncharacterized conserved protein [Function unknown]; Region: COG2835
233413004921	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413004922	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413004923	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
233413004924	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
233413004925	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
233413004926	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
233413004927	Walker A/P-loop; other site
233413004928	ATP binding site [chemical binding]; other site
233413004929	Q-loop/lid; other site
233413004930	ABC transporter signature motif; other site
233413004931	Walker B; other site
233413004932	D-loop; other site
233413004933	H-loop/switch region; other site
233413004934	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
233413004935	active site
233413004936	DNA binding site [nucleotide binding]
233413004937	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
233413004938	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
233413004939	active site
233413004940	HIGH motif; other site
233413004941	dimer interface [polypeptide binding]; other site
233413004942	KMSKS motif; other site
233413004943	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
233413004944	RNA binding surface [nucleotide binding]; other site
233413004945	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413004946	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
233413004947	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
233413004948	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
233413004949	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
233413004950	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
233413004951	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
233413004952	RNA binding surface [nucleotide binding]; other site
233413004953	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
233413004954	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004955	S-adenosylmethionine binding site [chemical binding]; other site
233413004956	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
233413004957	DNA repair protein RecN; Region: recN; TIGR00634
233413004958	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
233413004959	Walker A/P-loop; other site
233413004960	ATP binding site [chemical binding]; other site
233413004961	Q-loop/lid; other site
233413004962	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
233413004963	ABC transporter signature motif; other site
233413004964	Walker B; other site
233413004965	D-loop; other site
233413004966	H-loop/switch region; other site
233413004967	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
233413004968	Thiamine pyrophosphokinase; Region: TPK; cd07995
233413004969	active site
233413004970	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
233413004971	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
233413004972	CTP synthetase; Validated; Region: pyrG; PRK05380
233413004973	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
233413004974	Catalytic site [active]
233413004975	active site
233413004976	UTP binding site [chemical binding]; other site
233413004977	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
233413004978	active site
233413004979	putative oxyanion hole; other site
233413004980	catalytic triad [active]
233413004981	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
233413004982	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
233413004983	dimer interface [polypeptide binding]; other site
233413004984	ADP-ribose binding site [chemical binding]; other site
233413004985	active site
233413004986	nudix motif; other site
233413004987	metal binding site [ion binding]; metal-binding site
233413004988	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
233413004989	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
233413004990	active site
233413004991	Int/Topo IB signature motif; other site
233413004992	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413004993	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413004994	active site
233413004995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413004996	S-adenosylmethionine binding site [chemical binding]; other site
233413004997	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
233413004998	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413004999	PPE family; Region: PPE; pfam00823
233413005000	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005001	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005002	PPE family; Region: PPE; pfam00823
233413005003	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005004	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
233413005005	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
233413005006	Sulfate transporter family; Region: Sulfate_transp; pfam00916
233413005007	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
233413005008	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
233413005009	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
233413005010	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413005011	P-loop; other site
233413005012	Magnesium ion binding site [ion binding]; other site
233413005013	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
233413005014	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
233413005015	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
233413005016	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
233413005017	RNA binding surface [nucleotide binding]; other site
233413005018	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
233413005019	active site
233413005020	cytidylate kinase; Provisional; Region: cmk; PRK00023
233413005021	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
233413005022	CMP-binding site; other site
233413005023	The sites determining sugar specificity; other site
233413005024	GTP-binding protein Der; Reviewed; Region: PRK03003
233413005025	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
233413005026	G1 box; other site
233413005027	GTP/Mg2+ binding site [chemical binding]; other site
233413005028	Switch I region; other site
233413005029	G2 box; other site
233413005030	Switch II region; other site
233413005031	G3 box; other site
233413005032	G4 box; other site
233413005033	G5 box; other site
233413005034	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
233413005035	G1 box; other site
233413005036	GTP/Mg2+ binding site [chemical binding]; other site
233413005037	Switch I region; other site
233413005038	G2 box; other site
233413005039	G3 box; other site
233413005040	Switch II region; other site
233413005041	G4 box; other site
233413005042	G5 box; other site
233413005043	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
233413005044	short chain dehydrogenase; Provisional; Region: PRK07060
233413005045	classical (c) SDRs; Region: SDR_c; cd05233
233413005046	NAD(P) binding site [chemical binding]; other site
233413005047	active site
233413005048	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
233413005049	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
233413005050	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
233413005051	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
233413005052	Cupin domain; Region: Cupin_2; cl17218
233413005053	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
233413005054	Transcriptional regulator [Transcription]; Region: IclR; COG1414
233413005055	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
233413005056	putative switch regulator; other site
233413005057	non-specific DNA interactions [nucleotide binding]; other site
233413005058	DNA binding site [nucleotide binding]
233413005059	sequence specific DNA binding site [nucleotide binding]; other site
233413005060	putative cAMP binding site [chemical binding]; other site
233413005061	Bacterial transcriptional regulator; Region: IclR; pfam01614
233413005062	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
233413005063	putative active site [active]
233413005064	homotetrameric interface [polypeptide binding]; other site
233413005065	metal binding site [ion binding]; metal-binding site
233413005066	biotin carboxylase-like protein; Validated; Region: PRK06524
233413005067	ATP-grasp domain; Region: ATP-grasp_4; cl17255
233413005068	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
233413005069	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413005070	dimerization interface [polypeptide binding]; other site
233413005071	putative DNA binding site [nucleotide binding]; other site
233413005072	putative Zn2+ binding site [ion binding]; other site
233413005073	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413005074	FAD binding domain; Region: FAD_binding_4; pfam01565
233413005075	Berberine and berberine like; Region: BBE; pfam08031
233413005076	TIGR03086 family protein; Region: TIGR03086
233413005077	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413005078	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413005079	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413005080	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
233413005081	NAD(P) binding site [chemical binding]; other site
233413005082	catalytic residues [active]
233413005083	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
233413005084	putative catalytic residue [active]
233413005085	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
233413005086	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
233413005087	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
233413005088	gating phenylalanine in ion channel; other site
233413005089	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
233413005090	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
233413005091	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
233413005092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413005093	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
233413005094	putative substrate translocation pore; other site
233413005095	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
233413005096	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
233413005097	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
233413005098	Sulfate transporter family; Region: Sulfate_transp; pfam00916
233413005099	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
233413005100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
233413005101	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
233413005102	putative active site [active]
233413005103	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413005104	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413005105	active site
233413005106	ATP binding site [chemical binding]; other site
233413005107	substrate binding site [chemical binding]; other site
233413005108	activation loop (A-loop); other site
233413005109	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
233413005110	Thioredoxin; Region: Thioredoxin_4; cl17273
233413005111	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
233413005112	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
233413005113	active site
233413005114	metal binding site [ion binding]; metal-binding site
233413005115	nudix motif; other site
233413005116	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413005117	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413005118	active site
233413005119	ATP binding site [chemical binding]; other site
233413005120	substrate binding site [chemical binding]; other site
233413005121	activation loop (A-loop); other site
233413005122	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413005123	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413005124	phosphopeptide binding site; other site
233413005125	Proline-rich; Region: Pro-rich; pfam15240
233413005126	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413005127	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413005128	phosphopeptide binding site; other site
233413005129	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
233413005130	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
233413005131	Walker A/P-loop; other site
233413005132	ATP binding site [chemical binding]; other site
233413005133	Q-loop/lid; other site
233413005134	ABC transporter signature motif; other site
233413005135	Walker B; other site
233413005136	D-loop; other site
233413005137	H-loop/switch region; other site
233413005138	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
233413005139	acyl-CoA synthetase; Provisional; Region: PRK13388
233413005140	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413005141	acyl-activating enzyme (AAE) consensus motif; other site
233413005142	AMP binding site [chemical binding]; other site
233413005143	active site
233413005144	CoA binding site [chemical binding]; other site
233413005145	hypothetical protein; Provisional; Region: PRK06185
233413005146	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413005147	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
233413005148	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005149	PPE family; Region: PPE; pfam00823
233413005150	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005151	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005152	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005153	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005154	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005155	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
233413005156	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
233413005157	Phosphoesterase family; Region: Phosphoesterase; pfam04185
233413005158	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
233413005159	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
233413005160	sulfite oxidase; Provisional; Region: PLN00177
233413005161	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
233413005162	Moco binding site; other site
233413005163	metal coordination site [ion binding]; other site
233413005164	dimerization interface [polypeptide binding]; other site
233413005165	Transport protein; Region: actII; TIGR00833
233413005166	MMPL family; Region: MMPL; pfam03176
233413005167	MMPL family; Region: MMPL; pfam03176
233413005168	Cutinase; Region: Cutinase; pfam01083
233413005169	PE family; Region: PE; pfam00934
233413005170	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413005171	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413005172	Uncharacterized conserved protein [Function unknown]; Region: COG0393
233413005173	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
233413005174	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413005175	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413005176	active site
233413005177	Integrase core domain; Region: rve; pfam00665
233413005178	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
233413005179	putative homodimer interface [polypeptide binding]; other site
233413005180	putative homotetramer interface [polypeptide binding]; other site
233413005181	putative allosteric switch controlling residues; other site
233413005182	putative metal binding site [ion binding]; other site
233413005183	putative homodimer-homodimer interface [polypeptide binding]; other site
233413005184	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
233413005185	PE family; Region: PE; pfam00934
233413005186	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
233413005187	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
233413005188	dimer interface [polypeptide binding]; other site
233413005189	active site
233413005190	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
233413005191	substrate binding site [chemical binding]; other site
233413005192	catalytic residue [active]
233413005193	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
233413005194	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
233413005195	metal binding site [ion binding]; metal-binding site
233413005196	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
233413005197	FAD binding domain; Region: FAD_binding_4; pfam01565
233413005198	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
233413005199	ANTAR domain; Region: ANTAR; pfam03861
233413005200	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
233413005201	Transcriptional regulator [Transcription]; Region: IclR; COG1414
233413005202	Bacterial transcriptional regulator; Region: IclR; pfam01614
233413005203	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413005204	FAD binding domain; Region: FAD_binding_4; pfam01565
233413005205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413005206	Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382
233413005207	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413005208	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
233413005209	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
233413005210	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
233413005211	Protein of unknown function (DUF690); Region: DUF690; pfam05108
233413005212	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
233413005213	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413005214	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
233413005215	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413005216	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413005217	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413005218	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
233413005219	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005220	PPE family; Region: PPE; pfam00823
233413005221	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005222	PE family; Region: PE; pfam00934
233413005223	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005224	PPE family; Region: PPE; pfam00823
233413005225	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005226	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005227	PPE family; Region: PPE; pfam00823
233413005228	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005229	PE family; Region: PE; pfam00934
233413005230	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
233413005231	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
233413005232	EspG family; Region: ESX-1_EspG; pfam14011
233413005233	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
233413005234	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
233413005235	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
233413005236	catalytic residues [active]
233413005237	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
233413005238	active site
233413005239	catalytic residues [active]
233413005240	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
233413005241	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
233413005242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
233413005243	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413005244	Walker A motif; other site
233413005245	ATP binding site [chemical binding]; other site
233413005246	Walker B motif; other site
233413005247	arginine finger; other site
233413005248	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005249	PPE family; Region: PPE; pfam00823
233413005250	PE-PPE domain; Region: PE-PPE; pfam08237
233413005251	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005252	PPE family; Region: PPE; pfam00823
233413005253	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005254	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005255	PPE family; Region: PPE; pfam00823
233413005256	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005257	PE family; Region: PE; pfam00934
233413005258	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413005259	PE family; Region: PE; pfam00934
233413005260	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005261	PPE family; Region: PPE; pfam00823
233413005262	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005263	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005264	PPE family; Region: PPE; pfam00823
233413005265	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413005266	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005267	PPE family; Region: PPE; pfam00823
233413005268	Mb1839, PPE33b, len: 282 aa. Equivalent to 3' end of Rv1809, len: 468 aa, from Mycobacterium tuberculosis strain H37Rv, (). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, E(): 0, (51.2% identity in 471 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (c-t), splits PPE33 into 2 parts, PPE33a and PPE33b, with PPE33a being truncated.;PPE FAMILY PROTEIN [SECOND PART]
233413005269	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413005270	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
233413005271	MgtC family; Region: MgtC; pfam02308
233413005272	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
233413005273	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413005274	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
233413005275	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
233413005276	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
233413005277	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413005278	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413005279	similar to hypothetical protein; Mb1847, -, len: 26 aa. Equivalent to Rv1816A, len: 26 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 26 aa overlap). Conserved hypothetical protein.
233413005280	hypothetical protein; Validated; Region: PRK07121
233413005281	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413005282	PE family; Region: PE; pfam00934
233413005283	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
233413005284	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
233413005285	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
233413005286	hypothetical protein; Provisional; Region: PRK05858
233413005287	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
233413005288	PYR/PP interface [polypeptide binding]; other site
233413005289	dimer interface [polypeptide binding]; other site
233413005290	TPP binding site [chemical binding]; other site
233413005291	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
233413005292	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
233413005293	TPP-binding site; other site
233413005294	dimer interface [polypeptide binding]; other site
233413005295	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
233413005296	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
233413005297	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413005298	nucleotide binding region [chemical binding]; other site
233413005299	ATP-binding site [chemical binding]; other site
233413005300	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
233413005301	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
233413005302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
233413005303	Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856
233413005304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
233413005305	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
233413005306	lipoyl attachment site [posttranslational modification]; other site
233413005307	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413005308	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413005309	phosphopeptide binding site; other site
233413005310	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
233413005311	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
233413005312	DNA binding residues [nucleotide binding]
233413005313	Bifunctional nuclease; Region: DNase-RNase; pfam02577
233413005314	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
233413005315	DNA binding residues [nucleotide binding]
233413005316	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
233413005317	putative dimer interface [polypeptide binding]; other site
233413005318	glycine dehydrogenase; Provisional; Region: PRK05367
233413005319	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
233413005320	tetramer interface [polypeptide binding]; other site
233413005321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413005322	catalytic residue [active]
233413005323	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
233413005324	tetramer interface [polypeptide binding]; other site
233413005325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413005326	catalytic residue [active]
233413005327	haloalkane dehalogenase; Provisional; Region: PRK03204
233413005328	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413005329	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
233413005330	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
233413005331	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
233413005332	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
233413005333	metal ion-dependent adhesion site (MIDAS); other site
233413005334	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
233413005335	active site
233413005336	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413005337	putative active site [active]
233413005338	PE family; Region: PE; pfam00934
233413005339	Domain of unknown function DUF21; Region: DUF21; pfam01595
233413005340	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
233413005341	FOG: CBS domain [General function prediction only]; Region: COG0517
233413005342	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
233413005343	Domain of unknown function DUF21; Region: DUF21; pfam01595
233413005344	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
233413005345	Transporter associated domain; Region: CorC_HlyC; smart01091
233413005346	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
233413005347	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
233413005348	active site
233413005349	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
233413005350	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
233413005351	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
233413005352	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
233413005353	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
233413005354	Predicted transcriptional regulator [Transcription]; Region: COG3682
233413005355	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
233413005356	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
233413005357	CoenzymeA binding site [chemical binding]; other site
233413005358	subunit interaction site [polypeptide binding]; other site
233413005359	PHB binding site; other site
233413005360	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
233413005361	alpha-gamma subunit interface [polypeptide binding]; other site
233413005362	beta-gamma subunit interface [polypeptide binding]; other site
233413005363	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
233413005364	gamma-beta subunit interface [polypeptide binding]; other site
233413005365	alpha-beta subunit interface [polypeptide binding]; other site
233413005366	urease subunit alpha; Reviewed; Region: ureC; PRK13206
233413005367	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
233413005368	subunit interactions [polypeptide binding]; other site
233413005369	active site
233413005370	flap region; other site
233413005371	UreF; Region: UreF; cl19817
233413005372	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413005373	UreD urease accessory protein; Region: UreD; cl00530
233413005374	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
233413005375	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413005376	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
233413005377	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413005378	classical (c) SDRs; Region: SDR_c; cd05233
233413005379	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
233413005380	NAD(P) binding site [chemical binding]; other site
233413005381	active site
233413005382	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
233413005383	sulfate transport protein; Provisional; Region: cysT; CHL00187
233413005384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413005385	dimer interface [polypeptide binding]; other site
233413005386	conserved gate region; other site
233413005387	putative PBP binding loops; other site
233413005388	ABC-ATPase subunit interface; other site
233413005389	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
233413005390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413005391	Walker A/P-loop; other site
233413005392	ATP binding site [chemical binding]; other site
233413005393	Q-loop/lid; other site
233413005394	ABC transporter signature motif; other site
233413005395	Walker B; other site
233413005396	D-loop; other site
233413005397	H-loop/switch region; other site
233413005398	TOBE domain; Region: TOBE; pfam03459
233413005399	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
233413005400	Predicted membrane protein [Function unknown]; Region: COG2261
233413005401	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
233413005402	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
233413005403	putative NAD(P) binding site [chemical binding]; other site
233413005404	putative substrate binding site [chemical binding]; other site
233413005405	catalytic Zn binding site [ion binding]; other site
233413005406	structural Zn binding site [ion binding]; other site
233413005407	CAAX protease self-immunity; Region: Abi; pfam02517
233413005408	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
233413005409	MOSC domain; Region: MOSC; pfam03473
233413005410	short chain dehydrogenase; Provisional; Region: PRK07825
233413005411	classical (c) SDRs; Region: SDR_c; cd05233
233413005412	NAD(P) binding site [chemical binding]; other site
233413005413	active site
233413005414	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
233413005415	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
233413005416	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
233413005417	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
233413005418	active site
233413005419	hypothetical protein; Provisional; Region: PRK12320
233413005420	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413005421	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
233413005422	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413005423	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413005424	Reductase C-terminal; Region: Reductase_C; pfam14759
233413005425	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
233413005426	Domain of unknown function (DUF385); Region: DUF385; pfam04075
233413005427	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
233413005428	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
233413005429	active site
233413005430	substrate binding site [chemical binding]; other site
233413005431	FMN binding site [chemical binding]; other site
233413005432	putative catalytic residues [active]
233413005433	Uncharacterized conserved protein [Function unknown]; Region: COG5579
233413005434	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
233413005435	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
233413005436	Ferritin-like domain; Region: Ferritin; pfam00210
233413005437	heme binding site [chemical binding]; other site
233413005438	ferroxidase pore; other site
233413005439	ferroxidase diiron center [ion binding]; other site
233413005440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413005441	putative substrate translocation pore; other site
233413005442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413005443	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
233413005444	23S rRNA interface [nucleotide binding]; other site
233413005445	L3 interface [polypeptide binding]; other site
233413005446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
233413005447	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
233413005448	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
233413005449	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
233413005450	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413005451	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
233413005452	short chain dehydrogenase; Provisional; Region: PRK08267
233413005453	classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931
233413005454	putative NAD(P) binding site [chemical binding]; other site
233413005455	active site
233413005456	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
233413005457	hydrophobic ligand binding site; other site
233413005458	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
233413005459	chorismate mutase; Provisional; Region: PRK09269
233413005460	chorismate mutase, putative; Region: CM_mono2; TIGR01806
233413005461	Predicted esterase [General function prediction only]; Region: COG0627
233413005462	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
233413005463	Leucine carboxyl methyltransferase; Region: LCM; cl01306
233413005464	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413005465	Uncharacterized conserved protein [Function unknown]; Region: COG2353
233413005466	Nitronate monooxygenase; Region: NMO; pfam03060
233413005467	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
233413005468	FMN binding site [chemical binding]; other site
233413005469	substrate binding site [chemical binding]; other site
233413005470	putative catalytic residue [active]
233413005471	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
233413005472	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
233413005473	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
233413005474	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
233413005475	NAD(P) binding site [chemical binding]; other site
233413005476	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
233413005477	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
233413005478	putative active site [active]
233413005479	dimerization interface [polypeptide binding]; other site
233413005480	putative tRNAtyr binding site [nucleotide binding]; other site
233413005481	Domain of unknown function DUF77; Region: DUF77; pfam01910
233413005482	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
233413005483	putative ADP-ribose binding site [chemical binding]; other site
233413005484	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413005485	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413005486	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413005487	cyclase homology domain; Region: CHD; cd07302
233413005488	nucleotidyl binding site; other site
233413005489	metal binding site [ion binding]; metal-binding site
233413005490	dimer interface [polypeptide binding]; other site
233413005491	competence damage-inducible protein A; Provisional; Region: PRK00549
233413005492	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
233413005493	putative MPT binding site; other site
233413005494	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
233413005495	putative sialic acid transporter; Region: 2A0112; TIGR00891
233413005496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413005497	putative substrate translocation pore; other site
233413005498	Predicted membrane protein [Function unknown]; Region: COG1950
233413005499	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
233413005500	anti sigma factor interaction site; other site
233413005501	regulatory phosphorylation site [posttranslational modification]; other site
233413005502	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413005503	FAD dependent oxidoreductase; Region: DAO; pfam01266
233413005504	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413005505	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
233413005506	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
233413005507	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
233413005508	dimer interface [polypeptide binding]; other site
233413005509	active site
233413005510	heme binding site [chemical binding]; other site
233413005511	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
233413005512	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
233413005513	metal binding site 2 [ion binding]; metal-binding site
233413005514	putative DNA binding helix; other site
233413005515	metal binding site 1 [ion binding]; metal-binding site
233413005516	dimer interface [polypeptide binding]; other site
233413005517	structural Zn2+ binding site [ion binding]; other site
233413005518	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
233413005519	substrate binding site [chemical binding]; other site
233413005520	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
233413005521	substrate binding site [chemical binding]; other site
233413005522	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
233413005523	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275
233413005524	putative NAD(P) binding site [chemical binding]; other site
233413005525	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
233413005526	isocitrate lyase; Region: PLN02892
233413005527	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
233413005528	tetramer interface [polypeptide binding]; other site
233413005529	active site
233413005530	Mg2+/Mn2+ binding site [ion binding]; other site
233413005531	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005532	PPE family; Region: PPE; pfam00823
233413005533	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005534	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005535	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005536	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005537	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005538	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005539	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005540	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005541	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005542	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005543	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005544	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005545	Mb1952c, PPE35b, len: 334 aa. Equivalent to 3' end of Rv1918c, len: 987 aa, from Mycobacterium tuberculosis strain H37Rv, (99.1% identity in 334 aa overlap). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 M. tuberculosis cosmid (1053 aa), FASTA scores: opt: 3404, E(): 0, (65.6% identity in 1058 aa overlap). Also similar to MTV004.05, MTY13E10.17, MTV014.03, MTCY3C7.23, MTCY6G11.05, MTCY48.17, MTV004.03, MTCY31.07, MTCY4C12.36, MTCY180.01, etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts, PPE35a and PPE35b.;PPE FAMILY PROTEIN
233413005546	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005547	PPE family; Region: PPE; pfam00823
233413005548	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005549	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005550	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005551	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413005552	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
233413005553	putative hydrophobic ligand binding site [chemical binding]; other site
233413005554	protein interface [polypeptide binding]; other site
233413005555	gate; other site
233413005556	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
233413005557	putative acyl-acceptor binding pocket; other site
233413005558	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
233413005559	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
233413005560	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
233413005561	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413005562	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
233413005563	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413005564	acyl-activating enzyme (AAE) consensus motif; other site
233413005565	active site
233413005566	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
233413005567	Uncharacterized conserved protein [Function unknown]; Region: COG3361
233413005568	short chain dehydrogenase; Provisional; Region: PRK05867
233413005569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413005570	NAD(P) binding site [chemical binding]; other site
233413005571	active site
233413005572	TIGR03085 family protein; Region: TIGR03085
233413005573	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413005574	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
233413005575	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
233413005576	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
233413005577	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
233413005578	conserved cys residue [active]
233413005579	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
233413005580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
233413005581	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
233413005582	dimer interface [polypeptide binding]; other site
233413005583	catalytic triad [active]
233413005584	peroxidatic and resolving cysteines [active]
233413005585	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413005586	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
233413005587	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
233413005588	active site
233413005589	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413005590	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
233413005591	FAD binding site [chemical binding]; other site
233413005592	substrate binding site [chemical binding]; other site
233413005593	catalytic base [active]
233413005594	enoyl-CoA hydratase; Provisional; Region: PRK08290
233413005595	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413005596	substrate binding site [chemical binding]; other site
233413005597	oxyanion hole (OAH) forming residues; other site
233413005598	trimer interface [polypeptide binding]; other site
233413005599	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
233413005600	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
233413005601	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413005602	catalytic loop [active]
233413005603	iron binding site [ion binding]; other site
233413005604	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
233413005605	FAD binding pocket [chemical binding]; other site
233413005606	FAD binding motif [chemical binding]; other site
233413005607	phosphate binding motif [ion binding]; other site
233413005608	beta-alpha-beta structure motif; other site
233413005609	NAD binding pocket [chemical binding]; other site
233413005610	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
233413005611	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413005612	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413005613	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413005614	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
233413005615	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
233413005616	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
233413005617	dimerization interface [polypeptide binding]; other site
233413005618	active site
233413005619	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
233413005620	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
233413005621	putative NAD(P) binding site [chemical binding]; other site
233413005622	homodimer interface [polypeptide binding]; other site
233413005623	active site
233413005624	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
233413005625	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
233413005626	SEC-C motif; Region: SEC-C; cl19389
233413005627	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413005628	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413005629	active site
233413005630	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
233413005631	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
233413005632	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
233413005633	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413005634	non-specific DNA binding site [nucleotide binding]; other site
233413005635	salt bridge; other site
233413005636	sequence-specific DNA binding site [nucleotide binding]; other site
233413005637	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
233413005638	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
233413005639	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
233413005640	putative active site [active]
233413005641	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413005642	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413005643	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413005644	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413005645	Permease; Region: Permease; cl00510
233413005646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413005647	S-adenosylmethionine binding site [chemical binding]; other site
233413005648	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
233413005649	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
233413005650	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
233413005651	dimer interface [polypeptide binding]; other site
233413005652	putative radical transfer pathway; other site
233413005653	diiron center [ion binding]; other site
233413005654	tyrosyl radical; other site
233413005655	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
233413005656	putative active site [active]
233413005657	PE family; Region: PE; pfam00934
233413005658	Cutinase; Region: Cutinase; pfam01083
233413005659	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
233413005660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
233413005661	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
233413005662	dimerization interface [polypeptide binding]; other site
233413005663	Lysine efflux permease [General function prediction only]; Region: COG1279
233413005664	Cellulose binding domain; Region: CBM_2; pfam00553
233413005665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413005666	S-adenosylmethionine binding site [chemical binding]; other site
233413005667	Uncharacterized conserved protein [Function unknown]; Region: COG5654
233413005668	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
233413005669	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413005670	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
233413005671	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
233413005672	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413005673	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
233413005674	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
233413005675	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413005676	dimerization interface [polypeptide binding]; other site
233413005677	putative DNA binding site [nucleotide binding]; other site
233413005678	putative Zn2+ binding site [ion binding]; other site
233413005679	Hemerythrin-like domain; Region: Hr-like; cd12108
233413005680	Fe binding site [ion binding]; other site
233413005681	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413005682	Ligand Binding Site [chemical binding]; other site
233413005683	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413005684	Ligand Binding Site [chemical binding]; other site
233413005685	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
233413005686	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
233413005687	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413005688	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
233413005689	Soluble P-type ATPase [General function prediction only]; Region: COG4087
233413005690	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
233413005691	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
233413005692	tetramer interface [polypeptide binding]; other site
233413005693	active site
233413005694	Mg2+/Mn2+ binding site [ion binding]; other site
233413005695	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
233413005696	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
233413005697	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
233413005698	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
233413005699	homotetramer interface [polypeptide binding]; other site
233413005700	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
233413005701	NAD binding site [chemical binding]; other site
233413005702	homodimer interface [polypeptide binding]; other site
233413005703	active site
233413005704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413005705	S-adenosylmethionine binding site [chemical binding]; other site
233413005706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
233413005707	Predicted kinase [General function prediction only]; Region: COG0645
233413005708	AAA domain; Region: AAA_33; pfam13671
233413005709	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413005710	Ligand Binding Site [chemical binding]; other site
233413005711	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413005712	Ligand Binding Site [chemical binding]; other site
233413005713	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
233413005714	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
233413005715	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
233413005716	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
233413005717	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
233413005718	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
233413005719	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
233413005720	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
233413005721	Ferredoxin [Energy production and conversion]; Region: COG1146
233413005722	4Fe-4S binding domain; Region: Fer4; pfam00037
233413005723	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
233413005724	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
233413005725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413005726	Walker A motif; other site
233413005727	ATP binding site [chemical binding]; other site
233413005728	Walker B motif; other site
233413005729	arginine finger; other site
233413005730	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
233413005731	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
233413005732	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
233413005733	putative active site [active]
233413005734	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413005735	MarR family; Region: MarR_2; pfam12802
233413005736	Phage envelope protein [General function prediction only]; Region: COG5562
233413005737	Transposase; Region: DEDD_Tnp_IS110; pfam01548
233413005738	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
233413005739	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
233413005740	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
233413005741	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413005742	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413005743	active site
233413005744	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413005745	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
233413005746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413005747	non-specific DNA binding site [nucleotide binding]; other site
233413005748	salt bridge; other site
233413005749	sequence-specific DNA binding site [nucleotide binding]; other site
233413005750	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
233413005751	Uncharacterized conserved protein [Function unknown]; Region: COG2442
233413005752	Predicted helicase [General function prediction only]; Region: COG4889
233413005753	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413005754	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
233413005755	non-specific DNA binding site [nucleotide binding]; other site
233413005756	salt bridge; other site
233413005757	sequence-specific DNA binding site [nucleotide binding]; other site
233413005758	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
233413005759	Predicted helicase [General function prediction only]; Region: COG4889
233413005760	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
233413005761	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413005762	ATP binding site [chemical binding]; other site
233413005763	putative Mg++ binding site [ion binding]; other site
233413005764	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
233413005765	Methyltransferase domain; Region: Methyltransf_26; pfam13659
233413005766	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
233413005767	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413005768	Ligand Binding Site [chemical binding]; other site
233413005769	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413005770	Ligand Binding Site [chemical binding]; other site
233413005771	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
233413005772	GAF domain; Region: GAF_3; pfam13492
233413005773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
233413005774	Histidine kinase; Region: HisKA_3; pfam07730
233413005775	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413005776	Ligand Binding Site [chemical binding]; other site
233413005777	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
233413005778	putative substrate binding site [chemical binding]; other site
233413005779	putative ATP binding site [chemical binding]; other site
233413005780	Erythromycin esterase; Region: Erythro_esteras; cl17110
233413005781	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413005782	active site
233413005783	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
233413005784	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
233413005785	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
233413005786	putative dimer interface [polypeptide binding]; other site
233413005787	Nitroreductase family; Region: Nitroreductase; pfam00881
233413005788	dimer interface [polypeptide binding]; other site
233413005789	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
233413005790	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413005791	putative DNA binding site [nucleotide binding]; other site
233413005792	dimerization interface [polypeptide binding]; other site
233413005793	putative Zn2+ binding site [ion binding]; other site
233413005794	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
233413005795	putative hydrophobic ligand binding site [chemical binding]; other site
233413005796	CLM binding site; other site
233413005797	L1 loop; other site
233413005798	DNA binding site [nucleotide binding]
233413005799	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
233413005800	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413005801	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
233413005802	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
233413005803	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
233413005804	active site
233413005805	nucleophile elbow; other site
233413005806	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
233413005807	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
233413005808	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
233413005809	Walker A/P-loop; other site
233413005810	ATP binding site [chemical binding]; other site
233413005811	Q-loop/lid; other site
233413005812	ABC transporter signature motif; other site
233413005813	Walker B; other site
233413005814	D-loop; other site
233413005815	H-loop/switch region; other site
233413005816	TOBE domain; Region: TOBE_2; pfam08402
233413005817	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
233413005818	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413005819	dimer interface [polypeptide binding]; other site
233413005820	conserved gate region; other site
233413005821	putative PBP binding loops; other site
233413005822	ABC-ATPase subunit interface; other site
233413005823	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
233413005824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413005825	dimer interface [polypeptide binding]; other site
233413005826	conserved gate region; other site
233413005827	putative PBP binding loops; other site
233413005828	ABC-ATPase subunit interface; other site
233413005829	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
233413005830	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
233413005831	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
233413005832	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
233413005833	catalytic triad [active]
233413005834	metal binding site [ion binding]; metal-binding site
233413005835	conserved cis-peptide bond; other site
233413005836	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
233413005837	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
233413005838	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
233413005839	substrate binding pocket [chemical binding]; other site
233413005840	catalytic triad [active]
233413005841	hypothetical protein; Provisional; Region: PRK05865
233413005842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413005843	NAD(P) binding site [chemical binding]; other site
233413005844	active site
233413005845	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
233413005846	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413005847	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413005848	active site
233413005849	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413005850	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413005851	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413005852	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413005853	Enoylreductase; Region: PKS_ER; smart00829
233413005854	NAD(P) binding site [chemical binding]; other site
233413005855	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
233413005856	short chain dehydrogenase; Region: adh_short; pfam00106
233413005857	putative NADP binding site [chemical binding]; other site
233413005858	active site
233413005859	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413005860	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413005861	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413005862	active site
233413005863	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413005864	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413005865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413005866	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413005867	Enoylreductase; Region: PKS_ER; smart00829
233413005868	NAD(P) binding site [chemical binding]; other site
233413005869	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
233413005870	short chain dehydrogenase; Region: adh_short; pfam00106
233413005871	putative NADP binding site [chemical binding]; other site
233413005872	active site
233413005873	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413005874	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
233413005875	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
233413005876	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
233413005877	putative active site [active]
233413005878	catalytic triad [active]
233413005879	putative dimer interface [polypeptide binding]; other site
233413005880	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
233413005881	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
233413005882	Ligand binding site; other site
233413005883	Putative Catalytic site; other site
233413005884	DXD motif; other site
233413005885	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
233413005886	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
233413005887	active site
233413005888	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
233413005889	Dienelactone hydrolase family; Region: DLH; pfam01738
233413005890	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413005891	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
233413005892	30S ribosomal protein S18; Provisional; Region: PRK13401
233413005893	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
233413005894	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
233413005895	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
233413005896	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
233413005897	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
233413005898	intersubunit interface [polypeptide binding]; other site
233413005899	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
233413005900	ABC-ATPase subunit  interface; other site
233413005901	putative PBP binding regions; other site
233413005902	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
233413005903	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
233413005904	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
233413005905	precorrin-3B synthase; Region: CobG; TIGR02435
233413005906	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
233413005907	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
233413005908	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
233413005909	active site
233413005910	SAM binding site [chemical binding]; other site
233413005911	homodimer interface [polypeptide binding]; other site
233413005912	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
233413005913	active site
233413005914	SAM binding site [chemical binding]; other site
233413005915	homodimer interface [polypeptide binding]; other site
233413005916	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413005917	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413005918	S-adenosylmethionine binding site [chemical binding]; other site
233413005919	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
233413005920	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
233413005921	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
233413005922	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413005923	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
233413005924	DNA binding residues [nucleotide binding]
233413005925	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
233413005926	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
233413005927	active site
233413005928	SAM binding site [chemical binding]; other site
233413005929	homodimer interface [polypeptide binding]; other site
233413005930	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
233413005931	active site
233413005932	SAM binding site [chemical binding]; other site
233413005933	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
233413005934	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
233413005935	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
233413005936	active site
233413005937	catalytic site [active]
233413005938	Translocation protein Sec62; Region: Sec62; cl02170
233413005939	Protein of unknown function (DUF2563); Region: DUF2563; pfam10817
233413005940	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
233413005941	Mb2111, -, len: 110 aa. Similar to 3' end of Rv2084, len: 378 aa, from Mycobacterium tuberculosis strain H37Rv, (97.0% identity in 100 aa overlap). Hypothetical unknown protein. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis stain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts, Mb2110 and Mb2111.;HYPOTHETICAL PROTEIN
233413005942	putative transposase OrfB; Reviewed; Region: PHA02517
233413005943	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413005944	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413005945	active site
233413005946	ATP binding site [chemical binding]; other site
233413005947	substrate binding site [chemical binding]; other site
233413005948	activation loop (A-loop); other site
233413005949	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413005950	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
233413005951	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
233413005952	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
233413005953	active site
233413005954	5'-3' exonuclease; Region: 53EXOc; smart00475
233413005955	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
233413005956	active site
233413005957	metal binding site 1 [ion binding]; metal-binding site
233413005958	putative 5' ssDNA interaction site; other site
233413005959	metal binding site 3; metal-binding site
233413005960	metal binding site 2 [ion binding]; metal-binding site
233413005961	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
233413005962	putative DNA binding site [nucleotide binding]; other site
233413005963	putative metal binding site [ion binding]; other site
233413005964	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
233413005965	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
233413005966	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413005967	ATP binding site [chemical binding]; other site
233413005968	putative Mg++ binding site [ion binding]; other site
233413005969	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413005970	nucleotide binding region [chemical binding]; other site
233413005971	ATP-binding site [chemical binding]; other site
233413005972	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
233413005973	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
233413005974	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
233413005975	Predicted transcriptional regulator [Transcription]; Region: COG2378
233413005976	WYL domain; Region: WYL; pfam13280
233413005977	Predicted transcriptional regulator [Transcription]; Region: COG2378
233413005978	WYL domain; Region: WYL; pfam13280
233413005979	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
233413005980	PE family; Region: PE; pfam00934
233413005981	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413005982	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413005983	active site
233413005984	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
233413005985	SNF2 Helicase protein; Region: DUF3670; pfam12419
233413005986	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413005987	ATP binding site [chemical binding]; other site
233413005988	putative Mg++ binding site [ion binding]; other site
233413005989	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413005990	nucleotide binding region [chemical binding]; other site
233413005991	ATP-binding site [chemical binding]; other site
233413005992	Uncharacterized conserved protein [Function unknown]; Region: COG4279
233413005993	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413005994	putative active site [active]
233413005995	PE family; Region: PE; pfam00934
233413005996	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413005997	PPE family; Region: PPE; pfam00823
233413005998	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
233413005999	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
233413006000	active site
233413006001	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
233413006002	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
233413006003	active site
233413006004	Pup-like protein; Region: Pup; pfam05639
233413006005	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
233413006006	proteasome ATPase; Region: pup_AAA; TIGR03689
233413006007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413006008	Walker A motif; other site
233413006009	ATP binding site [chemical binding]; other site
233413006010	Walker B motif; other site
233413006011	arginine finger; other site
233413006012	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
233413006013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
233413006014	tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801
233413006015	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
233413006016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413006017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413006018	S-adenosylmethionine binding site [chemical binding]; other site
233413006019	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
233413006020	Predicted membrane protein [Function unknown]; Region: COG3918
233413006021	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
233413006022	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
233413006023	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
233413006024	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
233413006025	homodimer interface [polypeptide binding]; other site
233413006026	putative metal binding site [ion binding]; other site
233413006027	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413006028	PPE family; Region: PPE; pfam00823
233413006029	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
233413006030	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
233413006031	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
233413006032	substrate binding pocket [chemical binding]; other site
233413006033	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
233413006034	B12 binding site [chemical binding]; other site
233413006035	cobalt ligand [ion binding]; other site
233413006036	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
233413006037	PAC2 family; Region: PAC2; pfam09754
233413006038	PE family; Region: PE; pfam00934
233413006039	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
233413006040	short chain dehydrogenase; Provisional; Region: PRK05872
233413006041	classical (c) SDRs; Region: SDR_c; cd05233
233413006042	NAD(P) binding site [chemical binding]; other site
233413006043	active site
233413006044	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
233413006045	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
233413006046	active site
233413006047	HIGH motif; other site
233413006048	KMSKS motif; other site
233413006049	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
233413006050	putative tRNA binding surface [nucleotide binding]; other site
233413006051	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
233413006052	active site
233413006053	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413006054	conserved hypothetical protein; Region: TIGR03843
233413006055	conserved hypothetical protein; Region: TIGR03847
233413006056	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413006057	catalytic core [active]
233413006058	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
233413006059	dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036
233413006060	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
233413006061	quinone interaction residues [chemical binding]; other site
233413006062	active site
233413006063	catalytic residues [active]
233413006064	FMN binding site [chemical binding]; other site
233413006065	substrate binding site [chemical binding]; other site
233413006066	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
233413006067	substrate binding site [chemical binding]; other site
233413006068	hypothetical protein; Provisional; Region: PRK07906
233413006069	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
233413006070	putative metal binding site [ion binding]; other site
233413006071	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
233413006072	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
233413006073	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413006074	active site
233413006075	DivIVA protein; Region: DivIVA; pfam05103
233413006076	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
233413006077	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
233413006078	Predicted integral membrane protein [Function unknown]; Region: COG0762
233413006079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
233413006080	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
233413006081	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
233413006082	catalytic residue [active]
233413006083	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
233413006084	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
233413006085	nucleotide binding site [chemical binding]; other site
233413006086	Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091
233413006087	SulA interaction site; other site
233413006088	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
233413006089	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
233413006090	Cell division protein FtsQ; Region: FtsQ; pfam03799
233413006091	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
233413006092	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
233413006093	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
233413006094	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
233413006095	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
233413006096	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
233413006097	active site
233413006098	homodimer interface [polypeptide binding]; other site
233413006099	cell division protein FtsW; Region: ftsW; TIGR02614
233413006100	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
233413006101	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
233413006102	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
233413006103	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
233413006104	Mg++ binding site [ion binding]; other site
233413006105	putative catalytic motif [active]
233413006106	putative substrate binding site [chemical binding]; other site
233413006107	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
233413006108	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
233413006109	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
233413006110	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
233413006111	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
233413006112	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
233413006113	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
233413006114	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
233413006115	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413006116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413006117	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413006118	PE family; Region: PE; pfam00934
233413006119	GAGA binding protein-like family; Region: GAGA_bind; pfam06217
233413006120	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
233413006121	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
233413006122	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
233413006123	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
233413006124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
233413006125	MraZ protein; Region: MraZ; pfam02381
233413006126	MraZ protein; Region: MraZ; pfam02381
233413006127	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
233413006128	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
233413006129	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
233413006130	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
233413006131	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
233413006132	substrate binding pocket [chemical binding]; other site
233413006133	chain length determination region; other site
233413006134	substrate-Mg2+ binding site; other site
233413006135	catalytic residues [active]
233413006136	aspartate-rich region 1; other site
233413006137	active site lid residues [active]
233413006138	aspartate-rich region 2; other site
233413006139	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
233413006140	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413006141	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413006142	active site
233413006143	ATP binding site [chemical binding]; other site
233413006144	substrate binding site [chemical binding]; other site
233413006145	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
233413006146	substrate binding site [chemical binding]; other site
233413006147	activation loop (A-loop); other site
233413006148	activation loop (A-loop); other site
233413006149	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
233413006150	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
233413006151	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
233413006152	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
233413006153	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
233413006154	putative acyl-acceptor binding pocket; other site
233413006155	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
233413006156	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
233413006157	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
233413006158	putative hydrophobic ligand binding site [chemical binding]; other site
233413006159	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413006160	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
233413006161	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
233413006162	acyl-activating enzyme (AAE) consensus motif; other site
233413006163	putative AMP binding site [chemical binding]; other site
233413006164	putative active site [active]
233413006165	putative CoA binding site [chemical binding]; other site
233413006166	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
233413006167	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
233413006168	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
233413006169	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
233413006170	NlpC/P60 family; Region: NLPC_P60; pfam00877
233413006171	hypothetical protein; Validated; Region: PRK07883
233413006172	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
233413006173	active site
233413006174	catalytic site [active]
233413006175	substrate binding site [chemical binding]; other site
233413006176	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
233413006177	GIY-YIG motif/motif A; other site
233413006178	active site
233413006179	catalytic site [active]
233413006180	putative DNA binding site [nucleotide binding]; other site
233413006181	metal binding site [ion binding]; metal-binding site
233413006182	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
233413006183	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
233413006184	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
233413006185	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
233413006186	Subunit I/III interface [polypeptide binding]; other site
233413006187	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
233413006188	cytochrome c-550; Provisional; Region: psbV; cl17239
233413006189	Cytochrome c; Region: Cytochrom_C; pfam00034
233413006190	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
233413006191	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
233413006192	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
233413006193	iron-sulfur cluster [ion binding]; other site
233413006194	[2Fe-2S] cluster binding site [ion binding]; other site
233413006195	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
233413006196	heme bH binding site [chemical binding]; other site
233413006197	Qi binding site; other site
233413006198	intrachain domain interface; other site
233413006199	heme bL binding site [chemical binding]; other site
233413006200	interchain domain interface [polypeptide binding]; other site
233413006201	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
233413006202	Qo binding site; other site
233413006203	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
233413006204	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
233413006205	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
233413006206	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
233413006207	Cupredoxin superfamily; Region: Cupredoxin; cl19115
233413006208	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
233413006209	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
233413006210	dimer interface [polypeptide binding]; other site
233413006211	active site
233413006212	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
233413006213	Ligand Binding Site [chemical binding]; other site
233413006214	Molecular Tunnel; other site
233413006215	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
233413006216	substrate binding site [chemical binding]; other site
233413006217	ATP binding site [chemical binding]; other site
233413006218	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
233413006219	Glycerate kinase family; Region: Gly_kinase; pfam02595
233413006220	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
233413006221	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
233413006222	putative dimer interface [polypeptide binding]; other site
233413006223	active site pocket [active]
233413006224	putative cataytic base [active]
233413006225	Cobalamin-5-phosphate synthase; Region: CobS; pfam02654
233413006226	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
233413006227	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
233413006228	homodimer interface [polypeptide binding]; other site
233413006229	substrate-cofactor binding pocket; other site
233413006230	catalytic residue [active]
233413006231	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
233413006232	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
233413006233	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
233413006234	cyclase homology domain; Region: CHD; cd07302
233413006235	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413006236	nucleotidyl binding site; other site
233413006237	metal binding site [ion binding]; metal-binding site
233413006238	dimer interface [polypeptide binding]; other site
233413006239	multifunctional aminopeptidase A; Provisional; Region: PRK00913
233413006240	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
233413006241	interface (dimer of trimers) [polypeptide binding]; other site
233413006242	Substrate-binding/catalytic site; other site
233413006243	Zn-binding sites [ion binding]; other site
233413006244	short chain dehydrogenase; Validated; Region: PRK05855
233413006245	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413006246	classical (c) SDRs; Region: SDR_c; cd05233
233413006247	NAD(P) binding site [chemical binding]; other site
233413006248	active site
233413006249	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927
233413006250	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
233413006251	E3 interaction surface; other site
233413006252	lipoyl attachment site [posttranslational modification]; other site
233413006253	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
233413006254	E3 interaction surface; other site
233413006255	lipoyl attachment site [posttranslational modification]; other site
233413006256	e3 binding domain; Region: E3_binding; pfam02817
233413006257	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
233413006258	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
233413006259	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
233413006260	putative NAD(P) binding site [chemical binding]; other site
233413006261	putative active site [active]
233413006262	lipoate-protein ligase B; Provisional; Region: PRK14345
233413006263	lipoyl synthase; Provisional; Region: PRK05481
233413006264	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413006265	FeS/SAM binding site; other site
233413006266	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
233413006267	RDD family; Region: RDD; pfam06271
233413006268	glutamine synthetase, type I; Region: GlnA; TIGR00653
233413006269	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
233413006270	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
233413006271	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
233413006272	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
233413006273	metal binding triad; other site
233413006274	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
233413006275	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
233413006276	metal binding triad; other site
233413006277	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
233413006278	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
233413006279	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
233413006280	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
233413006281	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Region: ACP_syn_III; cl19161
233413006282	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
233413006283	TAP-like protein; Region: Abhydrolase_4; pfam08386
233413006284	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
233413006285	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413006286	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413006287	TAP-like protein; Region: Abhydrolase_4; pfam08386
233413006288	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
233413006289	oligomerization interface [polypeptide binding]; other site
233413006290	active site
233413006291	metal binding site [ion binding]; metal-binding site
233413006292	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
233413006293	putative active site; other site
233413006294	putative metal binding residues [ion binding]; other site
233413006295	signature motif; other site
233413006296	putative triphosphate binding site [ion binding]; other site
233413006297	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
233413006298	Oxygenase, catalyzing oxidative methylation of damaged DNA; Region: Oxygenase-NA; cl17606
233413006299	Oxygenase, catalyzing oxidative methylation of damaged DNA; Region: Oxygenase-NA; cl17606
233413006300	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
233413006301	RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279
233413006302	RNA/DNA hybrid binding site [nucleotide binding]; other site
233413006303	active site
233413006304	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413006305	catalytic core [active]
233413006306	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
233413006307	Putative zinc ribbon domain; Region: DUF164; pfam02591
233413006308	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
233413006309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
233413006310	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
233413006311	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413006312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413006313	homodimer interface [polypeptide binding]; other site
233413006314	catalytic residue [active]
233413006315	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
233413006316	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413006317	active site
233413006318	motif I; other site
233413006319	motif II; other site
233413006320	Low molecular weight phosphatase family; Region: LMWPc; cd00115
233413006321	active site
233413006322	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
233413006323	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
233413006324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
233413006325	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
233413006326	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
233413006327	dimer interface [polypeptide binding]; other site
233413006328	catalytic triad [active]
233413006329	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
233413006330	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
233413006331	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
233413006332	dimer interface [polypeptide binding]; other site
233413006333	TPP-binding site [chemical binding]; other site
233413006334	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
233413006335	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
233413006336	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
233413006337	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
233413006338	acyl carrier protein; Provisional; Region: acpP; PRK00982
233413006339	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
233413006340	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
233413006341	dimer interface [polypeptide binding]; other site
233413006342	active site
233413006343	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
233413006344	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
233413006345	dimer interface [polypeptide binding]; other site
233413006346	active site
233413006347	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
233413006348	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413006349	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413006350	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
233413006351	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
233413006352	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
233413006353	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413006354	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413006355	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413006356	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413006357	FAD binding domain; Region: FAD_binding_4; pfam01565
233413006358	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
233413006359	diacylglycerol kinase; Reviewed; Region: PRK11914
233413006360	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
233413006361	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
233413006362	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413006363	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413006364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413006365	S-adenosylmethionine binding site [chemical binding]; other site
233413006366	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
233413006367	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
233413006368	NAD binding site [chemical binding]; other site
233413006369	catalytic Zn binding site [ion binding]; other site
233413006370	substrate binding site [chemical binding]; other site
233413006371	structural Zn binding site [ion binding]; other site
233413006372	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
233413006373	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
233413006374	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
233413006375	putative active site [active]
233413006376	catalytic triad [active]
233413006377	putative dimer interface [polypeptide binding]; other site
233413006378	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
233413006379	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
233413006380	putative NAD(P) binding site [chemical binding]; other site
233413006381	active site
233413006382	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
233413006383	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
233413006384	nucleotide binding site [chemical binding]; other site
233413006385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413006386	putative substrate translocation pore; other site
233413006387	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413006388	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413006389	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
233413006390	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413006391	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
233413006392	dimerization interface [polypeptide binding]; other site
233413006393	ATP binding site [chemical binding]; other site
233413006394	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
233413006395	Septum formation; Region: Septum_form; pfam13845
233413006396	Protein of unknown function (DUF2695); Region: DUF2695; pfam10905
233413006397	Predicted membrane protein [Function unknown]; Region: COG2149
233413006398	Domain of unknown function (DUF202); Region: DUF202; pfam02656
233413006399	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413006400	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
233413006401	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
233413006402	putative active site [active]
233413006403	catalytic site [active]
233413006404	putative metal binding site [ion binding]; other site
233413006405	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413006406	FAD binding domain; Region: FAD_binding_4; pfam01565
233413006407	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
233413006408	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
233413006409	Transcriptional regulator [Transcription]; Region: LysR; COG0583
233413006410	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
233413006411	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
233413006412	dimerization interface [polypeptide binding]; other site
233413006413	Mediator of RNA pol II transcription subunit 19; Region: Med19; pfam10278
233413006414	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
233413006415	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
233413006416	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413006417	Secretory lipase; Region: LIP; pfam03583
233413006418	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413006419	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413006420	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
233413006421	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
233413006422	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
233413006423	CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134
233413006424	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
233413006425	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
233413006426	active site residue [active]
233413006427	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
233413006428	active site residue [active]
233413006429	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
233413006430	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
233413006431	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
233413006432	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413006433	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413006434	homodimer interface [polypeptide binding]; other site
233413006435	catalytic residue [active]
233413006436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196
233413006437	haloalkane dehalogenase; Provisional; Region: PRK00870
233413006438	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413006439	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
233413006440	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
233413006441	active site
233413006442	catalytic tetrad [active]
233413006443	heat shock protein 90; Provisional; Region: PRK05218
233413006444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413006445	ATP binding site [chemical binding]; other site
233413006446	Mg2+ binding site [ion binding]; other site
233413006447	G-X-G motif; other site
233413006448	Hsp90 protein; Region: HSP90; pfam00183
233413006449	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
233413006450	Cutinase; Region: Cutinase; pfam01083
233413006451	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
233413006452	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
233413006453	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
233413006454	Condensation domain; Region: Condensation; cl19241
233413006455	Uncharacterized conserved protein [Function unknown]; Region: COG0398
233413006456	Uncharacterized conserved protein [Function unknown]; Region: COG0398
233413006457	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413006458	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
233413006459	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413006460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
233413006461	Uncharacterized conserved protein [Function unknown]; Region: COG2442
233413006462	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
233413006463	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
233413006464	DNA binding site [nucleotide binding]
233413006465	active site
233413006466	Int/Topo IB signature motif; other site
233413006467	DNA binding domain, excisionase family; Region: excise; TIGR01764
233413006468	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
233413006469	Uncharacterized conserved protein [Function unknown]; Region: COG2128
233413006470	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
233413006471	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
233413006472	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
233413006473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413006474	dimer interface [polypeptide binding]; other site
233413006475	putative PBP binding loops; other site
233413006476	ABC-ATPase subunit interface; other site
233413006477	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
233413006478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413006479	dimer interface [polypeptide binding]; other site
233413006480	conserved gate region; other site
233413006481	putative PBP binding loops; other site
233413006482	ABC-ATPase subunit interface; other site
233413006483	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
233413006484	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
233413006485	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413006486	Ligand Binding Site [chemical binding]; other site
233413006487	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413006488	Ligand Binding Site [chemical binding]; other site
233413006489	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
233413006490	amino acid transporter; Region: 2A0306; TIGR00909
233413006491	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
233413006492	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
233413006493	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
233413006494	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413006495	catalytic residue [active]
233413006496	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
233413006497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413006498	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
233413006499	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
233413006500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413006501	putative DNA binding site [nucleotide binding]; other site
233413006502	putative Zn2+ binding site [ion binding]; other site
233413006503	AsnC family; Region: AsnC_trans_reg; pfam01037
233413006504	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
233413006505	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
233413006506	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
233413006507	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
233413006508	Walker A/P-loop; other site
233413006509	ATP binding site [chemical binding]; other site
233413006510	Q-loop/lid; other site
233413006511	ABC transporter signature motif; other site
233413006512	Walker B; other site
233413006513	D-loop; other site
233413006514	H-loop/switch region; other site
233413006515	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
233413006516	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
233413006517	Walker A/P-loop; other site
233413006518	ATP binding site [chemical binding]; other site
233413006519	Q-loop/lid; other site
233413006520	ABC transporter signature motif; other site
233413006521	Walker B; other site
233413006522	D-loop; other site
233413006523	H-loop/switch region; other site
233413006524	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413006525	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
233413006526	PE family; Region: PE; pfam00934
233413006527	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
233413006528	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413006529	putative substrate translocation pore; other site
233413006530	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
233413006531	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
233413006532	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
233413006533	conserved FAD binding motif [chemical binding]; other site
233413006534	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
233413006535	malate dehydrogenase; Provisional; Region: PRK13529
233413006536	Malic enzyme, N-terminal domain; Region: malic; pfam00390
233413006537	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
233413006538	NAD(P) binding site [chemical binding]; other site
233413006539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413006540	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413006541	putative substrate translocation pore; other site
233413006542	cysteine synthase; Region: PLN02565
233413006543	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
233413006544	dimer interface [polypeptide binding]; other site
233413006545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413006546	catalytic residue [active]
233413006547	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
233413006548	serine O-acetyltransferase; Region: cysE; TIGR01172
233413006549	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
233413006550	trimer interface [polypeptide binding]; other site
233413006551	active site
233413006552	substrate binding site [chemical binding]; other site
233413006553	CoA binding site [chemical binding]; other site
233413006554	Nitroreductase family; Region: Nitroreductase; pfam00881
233413006555	hypothetical protein; Validated; Region: PRK08223
233413006556	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
233413006557	ATP binding site [chemical binding]; other site
233413006558	substrate interface [chemical binding]; other site
233413006559	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413006560	MMPL family; Region: MMPL; pfam03176
233413006561	MMPL family; Region: MMPL; cl14618
233413006562	MMPL family; Region: MMPL; cl14618
233413006563	PE family; Region: PE; pfam00934
233413006564	DNA primase; Validated; Region: dnaG; PRK05667
233413006565	CHC2 zinc finger; Region: zf-CHC2; pfam01807
233413006566	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
233413006567	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
233413006568	active site
233413006569	metal binding site [ion binding]; metal-binding site
233413006570	interdomain interaction site; other site
233413006571	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
233413006572	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
233413006573	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
233413006574	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
233413006575	Zn2+ binding site [ion binding]; other site
233413006576	Mg2+ binding site [ion binding]; other site
233413006577	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
233413006578	TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536
233413006579	Proteins of 100 residues with WXG; Region: WXG100; cl02005
233413006580	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413006581	PPE family; Region: PPE; pfam00823
233413006582	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006583	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006584	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006585	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006586	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413006587	PPE family; Region: PPE; pfam00823
233413006588	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006589	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006590	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006591	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006592	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006593	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006594	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006595	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413006596	glycyl-tRNA synthetase; Provisional; Region: PRK04173
233413006597	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
233413006598	dimer interface [polypeptide binding]; other site
233413006599	motif 1; other site
233413006600	active site
233413006601	motif 2; other site
233413006602	motif 3; other site
233413006603	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
233413006604	anticodon binding site; other site
233413006605	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413006606	dimerization interface [polypeptide binding]; other site
233413006607	putative DNA binding site [nucleotide binding]; other site
233413006608	putative Zn2+ binding site [ion binding]; other site
233413006609	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
233413006610	metal binding site 2 [ion binding]; metal-binding site
233413006611	putative DNA binding helix; other site
233413006612	metal binding site 1 [ion binding]; metal-binding site
233413006613	dimer interface [polypeptide binding]; other site
233413006614	structural Zn2+ binding site [ion binding]; other site
233413006615	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
233413006616	active site
233413006617	dimer interface [polypeptide binding]; other site
233413006618	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
233413006619	Recombination protein O N terminal; Region: RecO_N; pfam11967
233413006620	Recombination protein O C terminal; Region: RecO_C; pfam02565
233413006621	amidase; Provisional; Region: PRK06061
233413006622	GTPase Era; Reviewed; Region: era; PRK00089
233413006623	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
233413006624	G1 box; other site
233413006625	GTP/Mg2+ binding site [chemical binding]; other site
233413006626	Switch I region; other site
233413006627	G2 box; other site
233413006628	Switch II region; other site
233413006629	G3 box; other site
233413006630	G4 box; other site
233413006631	G5 box; other site
233413006632	KH domain; Region: KH_2; pfam07650
233413006633	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
233413006634	Domain of unknown function DUF21; Region: DUF21; pfam01595
233413006635	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
233413006636	Transporter associated domain; Region: CorC_HlyC; smart01091
233413006637	metal-binding heat shock protein; Provisional; Region: PRK00016
233413006638	K homology RNA-binding domain; Region: KH; smart00322
233413006639	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
233413006640	PhoH-like protein; Region: PhoH; pfam02562
233413006641	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
233413006642	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
233413006643	PE family; Region: PE; pfam00934
233413006644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
233413006645	chaperone protein DnaJ; Provisional; Region: PRK14278
233413006646	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
233413006647	HSP70 interaction site [polypeptide binding]; other site
233413006648	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
233413006649	Zn binding sites [ion binding]; other site
233413006650	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
233413006651	dimer interface [polypeptide binding]; other site
233413006652	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
233413006653	HrcA protein C terminal domain; Region: HrcA; pfam01628
233413006654	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
233413006655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
233413006656	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413006657	Condensation domain; Region: Condensation; pfam00668
233413006658	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
233413006659	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
233413006660	acyl-activating enzyme (AAE) consensus motif; other site
233413006661	AMP binding site [chemical binding]; other site
233413006662	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413006663	Condensation domain; Region: Condensation; cl19241
233413006664	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
233413006665	Condensation domain; Region: Condensation; cl19241
233413006666	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
233413006667	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
233413006668	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
233413006669	acyl-activating enzyme (AAE) consensus motif; other site
233413006670	AMP binding site [chemical binding]; other site
233413006671	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413006672	Condensation domain; Region: Condensation; cl19241
233413006673	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
233413006674	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413006675	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413006676	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413006677	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413006678	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
233413006679	NADP binding site [chemical binding]; other site
233413006680	active site
233413006681	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413006682	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413006683	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
233413006684	active site
233413006685	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
233413006686	Condensation domain; Region: Condensation; cl19241
233413006687	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
233413006688	Nonribosomal peptide synthase; Region: NRPS; pfam08415
233413006689	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
233413006690	acyl-activating enzyme (AAE) consensus motif; other site
233413006691	AMP binding site [chemical binding]; other site
233413006692	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413006693	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
233413006694	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413006695	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
233413006696	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
233413006697	acyl-activating enzyme (AAE) consensus motif; other site
233413006698	active site
233413006699	AMP binding site [chemical binding]; other site
233413006700	substrate binding site [chemical binding]; other site
233413006701	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
233413006702	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413006703	salicylate synthase MbtI; Reviewed; Region: PRK07912
233413006704	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
233413006705	Predicted permease [General function prediction only]; Region: COG3329
233413006706	coproporphyrinogen III oxidase; Validated; Region: PRK05628
233413006707	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
233413006708	HemN C-terminal domain; Region: HemN_C; pfam06969
233413006709	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
233413006710	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
233413006711	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
233413006712	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
233413006713	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
233413006714	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
233413006715	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
233413006716	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
233413006717	Active Sites [active]
233413006718	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
233413006719	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
233413006720	putative active site [active]
233413006721	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
233413006722	putative active site [active]
233413006723	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
233413006724	OPT oligopeptide transporter protein; Region: OPT; cl14607
233413006725	OPT oligopeptide transporter protein; Region: OPT; cl14607
233413006726	PE family; Region: PE; pfam00934
233413006727	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
233413006728	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
233413006729	Walker A/P-loop; other site
233413006730	ATP binding site [chemical binding]; other site
233413006731	Q-loop/lid; other site
233413006732	ABC transporter signature motif; other site
233413006733	Walker B; other site
233413006734	D-loop; other site
233413006735	H-loop/switch region; other site
233413006736	TOBE domain; Region: TOBE; pfam03459
233413006737	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
233413006738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413006739	dimer interface [polypeptide binding]; other site
233413006740	conserved gate region; other site
233413006741	putative PBP binding loops; other site
233413006742	ABC-ATPase subunit interface; other site
233413006743	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
233413006744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413006745	dimer interface [polypeptide binding]; other site
233413006746	conserved gate region; other site
233413006747	putative PBP binding loops; other site
233413006748	ABC-ATPase subunit interface; other site
233413006749	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
233413006750	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
233413006751	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
233413006752	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413006753	GTP-binding protein LepA; Provisional; Region: PRK05433
233413006754	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
233413006755	G1 box; other site
233413006756	putative GEF interaction site [polypeptide binding]; other site
233413006757	GTP/Mg2+ binding site [chemical binding]; other site
233413006758	Switch I region; other site
233413006759	G2 box; other site
233413006760	G3 box; other site
233413006761	Switch II region; other site
233413006762	G4 box; other site
233413006763	G5 box; other site
233413006764	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
233413006765	Elongation Factor G, domain II; Region: EFG_II; pfam14492
233413006766	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
233413006767	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
233413006768	PemK-like protein; Region: PemK; pfam02452
233413006769	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
233413006770	FOG: CBS domain [General function prediction only]; Region: COG0517
233413006771	ribonuclease Z; Reviewed; Region: PRK00055
233413006772	PE family; Region: PE; pfam00934
233413006773	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
233413006774	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
233413006775	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
233413006776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
233413006777	Uncharacterized conserved protein [Function unknown]; Region: COG2308
233413006778	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
233413006779	hypothetical protein; Reviewed; Region: PRK07914
233413006780	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
233413006781	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
233413006782	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
233413006783	Competence protein; Region: Competence; pfam03772
233413006784	comEA protein; Region: comE; TIGR01259
233413006785	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
233413006786	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
233413006787	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413006788	Coenzyme A binding pocket [chemical binding]; other site
233413006789	Sterol carrier protein domain; Region: SCP2_2; pfam13530
233413006790	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
233413006791	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
233413006792	active site
233413006793	catalytic triad [active]
233413006794	oxyanion hole [active]
233413006795	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413006796	catalytic core [active]
233413006797	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
233413006798	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
233413006799	active site
233413006800	(T/H)XGH motif; other site
233413006801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413006802	S-adenosylmethionine binding site [chemical binding]; other site
233413006803	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
233413006804	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
233413006805	Transposase; Region: DEDD_Tnp_IS110; pfam01548
233413006806	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
233413006807	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
233413006808	metal ion-dependent adhesion site (MIDAS); other site
233413006809	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
233413006810	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413006811	Walker A motif; other site
233413006812	ATP binding site [chemical binding]; other site
233413006813	Walker B motif; other site
233413006814	arginine finger; other site
233413006815	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
233413006816	putative catalytic cysteine [active]
233413006817	Mb2452c, -, len: 101 aa. Equivalent to the second part of oxyR' pseudogene (see citation below).
233413006818	Mb2453c, -, len: 66 aa. Equivalent to the first part of oxyR' pseudogene (see citation below).
233413006819	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
233413006820	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
233413006821	dimer interface [polypeptide binding]; other site
233413006822	decamer (pentamer of dimers) interface [polypeptide binding]; other site
233413006823	catalytic triad [active]
233413006824	peroxidatic and resolving cysteines [active]
233413006825	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
233413006826	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
233413006827	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413006828	PPE family; Region: PPE; pfam00823
233413006829	PE family; Region: PE; pfam00934
233413006830	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
233413006831	Mechanosensitive ion channel; Region: MS_channel; pfam00924
233413006832	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413006833	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413006834	ligand binding site [chemical binding]; other site
233413006835	flexible hinge region; other site
233413006836	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413006837	dimerization interface [polypeptide binding]; other site
233413006838	Heme NO binding associated; Region: HNOBA; pfam07701
233413006839	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
233413006840	cyclase homology domain; Region: CHD; cd07302
233413006841	nucleotidyl binding site; other site
233413006842	metal binding site [ion binding]; metal-binding site
233413006843	dimer interface [polypeptide binding]; other site
233413006844	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
233413006845	substrate binding site [chemical binding]; other site
233413006846	dimer interface [polypeptide binding]; other site
233413006847	ATP binding site [chemical binding]; other site
233413006848	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
233413006849	NAD synthetase; Reviewed; Region: nadE; PRK02628
233413006850	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
233413006851	multimer interface [polypeptide binding]; other site
233413006852	active site
233413006853	catalytic triad [active]
233413006854	protein interface 1 [polypeptide binding]; other site
233413006855	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
233413006856	homodimer interface [polypeptide binding]; other site
233413006857	NAD binding pocket [chemical binding]; other site
233413006858	ATP binding pocket [chemical binding]; other site
233413006859	Mg binding site [ion binding]; other site
233413006860	active-site loop [active]
233413006861	gamma-glutamyl kinase; Provisional; Region: PRK05429
233413006862	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
233413006863	nucleotide binding site [chemical binding]; other site
233413006864	homotetrameric interface [polypeptide binding]; other site
233413006865	putative phosphate binding site [ion binding]; other site
233413006866	putative allosteric binding site; other site
233413006867	PUA domain; Region: PUA; pfam01472
233413006868	GTPase CgtA; Reviewed; Region: obgE; PRK12296
233413006869	GTP1/OBG; Region: GTP1_OBG; pfam01018
233413006870	Obg GTPase; Region: Obg; cd01898
233413006871	G1 box; other site
233413006872	GTP/Mg2+ binding site [chemical binding]; other site
233413006873	Switch I region; other site
233413006874	G2 box; other site
233413006875	G3 box; other site
233413006876	Switch II region; other site
233413006877	G4 box; other site
233413006878	G5 box; other site
233413006879	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
233413006880	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
233413006881	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
233413006882	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
233413006883	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
233413006884	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
233413006885	homodimer interface [polypeptide binding]; other site
233413006886	oligonucleotide binding site [chemical binding]; other site
233413006887	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
233413006888	Nucleoside diphosphate kinase; Region: NDK; pfam00334
233413006889	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
233413006890	active site
233413006891	multimer interface [polypeptide binding]; other site
233413006892	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
233413006893	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
233413006894	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
233413006895	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
233413006896	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
233413006897	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
233413006898	active site
233413006899	HIGH motif; other site
233413006900	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
233413006901	KMSKS motif; other site
233413006902	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
233413006903	tRNA binding surface [nucleotide binding]; other site
233413006904	anticodon binding site; other site
233413006905	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
233413006906	Uncharacterized conserved protein [Function unknown]; Region: COG3268
233413006907	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
233413006908	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
233413006909	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
233413006910	GTP binding site; other site
233413006911	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
233413006912	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
233413006913	TPP-binding site [chemical binding]; other site
233413006914	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
233413006915	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
233413006916	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
233413006917	dimer interface [polypeptide binding]; other site
233413006918	PYR/PP interface [polypeptide binding]; other site
233413006919	TPP binding site [chemical binding]; other site
233413006920	substrate binding site [chemical binding]; other site
233413006921	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413006922	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413006923	putative substrate translocation pore; other site
233413006924	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
233413006925	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
233413006926	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413006927	Walker A motif; other site
233413006928	ATP binding site [chemical binding]; other site
233413006929	Walker B motif; other site
233413006930	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
233413006931	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
233413006932	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
233413006933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413006934	putative substrate translocation pore; other site
233413006935	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
233413006936	oligomer interface [polypeptide binding]; other site
233413006937	active site residues [active]
233413006938	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
233413006939	oligomer interface [polypeptide binding]; other site
233413006940	active site residues [active]
233413006941	trigger factor; Provisional; Region: tig; PRK01490
233413006942	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
233413006943	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
233413006944	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
233413006945	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413006946	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
233413006947	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
233413006948	putative DNA binding site [nucleotide binding]; other site
233413006949	catalytic residue [active]
233413006950	putative H2TH interface [polypeptide binding]; other site
233413006951	putative catalytic residues [active]
233413006952	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
233413006953	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
233413006954	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
233413006955	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
233413006956	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
233413006957	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
233413006958	Zn binding site [ion binding]; other site
233413006959	ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838
233413006960	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413006961	active site
233413006962	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
233413006963	apolar tunnel; other site
233413006964	heme binding site [chemical binding]; other site
233413006965	dimerization interface [polypeptide binding]; other site
233413006966	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
233413006967	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
233413006968	active site
233413006969	catalytic site [active]
233413006970	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
233413006971	active site
233413006972	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
233413006973	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
233413006974	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
233413006975	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
233413006976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413006977	Walker A/P-loop; other site
233413006978	ATP binding site [chemical binding]; other site
233413006979	Q-loop/lid; other site
233413006980	ABC transporter signature motif; other site
233413006981	ABC transporter; Region: ABC_tran_2; pfam12848
233413006982	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
233413006983	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
233413006984	dimer interface [polypeptide binding]; other site
233413006985	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
233413006986	ssDNA binding site [nucleotide binding]; other site
233413006987	tetramer (dimer of dimers) interface [polypeptide binding]; other site
233413006988	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
233413006989	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
233413006990	putative acyl-acceptor binding pocket; other site
233413006991	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
233413006992	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
233413006993	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
233413006994	putative acyl-acceptor binding pocket; other site
233413006995	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413006996	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413006997	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
233413006998	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094
233413006999	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413007000	enoyl-CoA hydratase; Provisional; Region: PRK05870
233413007001	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413007002	substrate binding site [chemical binding]; other site
233413007003	oxyanion hole (OAH) forming residues; other site
233413007004	trimer interface [polypeptide binding]; other site
233413007005	Mb2512c, PE_PGRS42d, len: 274 aa. Similar to 3' end of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 274 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d.;PE-PGRS FAMILY PROTEIN [THIRD PART]
233413007006	Mb2513c, PE_PGRS42b, len: 284 aa. Similar to middle section of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 284 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d.;PE-PGRS FAMILY PROTEIN [SECOND PART]
233413007007	PE family; Region: PE; pfam00934
233413007008	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413007009	cyclase homology domain; Region: CHD; cd07302
233413007010	nucleotidyl binding site; other site
233413007011	metal binding site [ion binding]; metal-binding site
233413007012	dimer interface [polypeptide binding]; other site
233413007013	Predicted ATPase [General function prediction only]; Region: COG3903
233413007014	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413007015	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413007016	DNA binding residues [nucleotide binding]
233413007017	dimerization interface [polypeptide binding]; other site
233413007018	PE family; Region: PE; pfam00934
233413007019	TIGR00725 family protein; Region: TIGR00725
233413007020	thymidylate synthase; Provisional; Region: thyA; PRK00956
233413007021	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413007022	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
233413007023	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
233413007024	E3 interaction surface; other site
233413007025	lipoyl attachment site [posttranslational modification]; other site
233413007026	e3 binding domain; Region: E3_binding; pfam02817
233413007027	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
233413007028	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
233413007029	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
233413007030	alpha subunit interface [polypeptide binding]; other site
233413007031	TPP binding site [chemical binding]; other site
233413007032	heterodimer interface [polypeptide binding]; other site
233413007033	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
233413007034	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
233413007035	tetramer interface [polypeptide binding]; other site
233413007036	TPP-binding site [chemical binding]; other site
233413007037	heterodimer interface [polypeptide binding]; other site
233413007038	phosphorylation loop region [posttranslational modification]
233413007039	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
233413007040	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
233413007041	putative active site [active]
233413007042	putative catalytic site [active]
233413007043	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413007044	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413007045	active site
233413007046	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
233413007047	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
233413007048	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
233413007049	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
233413007050	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
233413007051	carboxyltransferase (CT) interaction site; other site
233413007052	biotinylation site [posttranslational modification]; other site
233413007053	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
233413007054	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
233413007055	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413007056	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413007057	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
233413007058	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
233413007059	AMP-binding domain protein; Validated; Region: PRK08315
233413007060	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
233413007061	acyl-activating enzyme (AAE) consensus motif; other site
233413007062	putative AMP binding site [chemical binding]; other site
233413007063	putative active site [active]
233413007064	putative CoA binding site [chemical binding]; other site
233413007065	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413007066	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413007067	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
233413007068	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
233413007069	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413007070	NAD(P) binding site [chemical binding]; other site
233413007071	active site
233413007072	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
233413007073	Domain of unknown function DUF87; Region: DUF87; cl19135
233413007074	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
233413007075	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
233413007076	catalytic site [active]
233413007077	putative active site [active]
233413007078	putative substrate binding site [chemical binding]; other site
233413007079	dimer interface [polypeptide binding]; other site
233413007080	Transposase, Mutator family; Region: Transposase_mut; pfam00872
233413007081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413007082	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
233413007083	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413007084	non-specific DNA binding site [nucleotide binding]; other site
233413007085	salt bridge; other site
233413007086	sequence-specific DNA binding site [nucleotide binding]; other site
233413007087	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
233413007088	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893
233413007089	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cd13430
233413007090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
233413007091	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
233413007092	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
233413007093	PE family; Region: PE; pfam00934
233413007094	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
233413007095	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
233413007096	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
233413007097	catalytic triad [active]
233413007098	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
233413007099	hypothetical protein; Provisional; Region: PRK08201
233413007100	active site
233413007101	metal binding site [ion binding]; metal-binding site
233413007102	dimer interface [polypeptide binding]; other site
233413007103	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
233413007104	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
233413007105	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
233413007106	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
233413007107	phosphate binding site [ion binding]; other site
233413007108	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
233413007109	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
233413007110	putative active site [active]
233413007111	putative catalytic site [active]
233413007112	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
233413007113	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
233413007114	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
233413007115	putative NAD(P) binding site [chemical binding]; other site
233413007116	active site
233413007117	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
233413007118	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
233413007119	active site
233413007120	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
233413007121	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
233413007122	putative active site [active]
233413007123	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
233413007124	Mrr N-terminal domain; Region: Mrr_N; pfam14338
233413007125	Restriction endonuclease; Region: Mrr_cat; pfam04471
233413007126	ERCC4 domain; Region: ERCC4; pfam02732
233413007127	Lsr2; Region: Lsr2; pfam11774
233413007128	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413007129	putative active site [active]
233413007130	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
233413007131	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
233413007132	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413007133	catalytic residue [active]
233413007134	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
233413007135	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
233413007136	putative RNA binding site [nucleotide binding]; other site
233413007137	elongation factor P; Validated; Region: PRK00529
233413007138	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
233413007139	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
233413007140	RNA binding site [nucleotide binding]; other site
233413007141	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
233413007142	RNA binding site [nucleotide binding]; other site
233413007143	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
233413007144	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
233413007145	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
233413007146	active site
233413007147	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
233413007148	trimer interface [polypeptide binding]; other site
233413007149	active site
233413007150	dimer interface [polypeptide binding]; other site
233413007151	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
233413007152	active site
233413007153	dimer interface [polypeptide binding]; other site
233413007154	metal binding site [ion binding]; metal-binding site
233413007155	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
233413007156	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
233413007157	ADP binding site [chemical binding]; other site
233413007158	magnesium binding site [ion binding]; other site
233413007159	putative shikimate binding site; other site
233413007160	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
233413007161	Tetramer interface [polypeptide binding]; other site
233413007162	active site
233413007163	FMN-binding site [chemical binding]; other site
233413007164	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
233413007165	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
233413007166	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
233413007167	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
233413007168	putative active site [active]
233413007169	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413007170	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
233413007171	oligomeric interface; other site
233413007172	putative active site [active]
233413007173	homodimer interface [polypeptide binding]; other site
233413007174	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
233413007175	putative active site [active]
233413007176	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413007177	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
233413007178	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
233413007179	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
233413007180	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
233413007181	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
233413007182	NAD(P) binding site [chemical binding]; other site
233413007183	shikimate binding site; other site
233413007184	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
233413007185	dimerization interface [polypeptide binding]; other site
233413007186	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
233413007187	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
233413007188	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
233413007189	motif 1; other site
233413007190	active site
233413007191	motif 2; other site
233413007192	motif 3; other site
233413007193	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
233413007194	DHHA1 domain; Region: DHHA1; pfam02272
233413007195	Uncharacterized conserved protein [Function unknown]; Region: COG0432
233413007196	recombination factor protein RarA; Reviewed; Region: PRK13342
233413007197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413007198	Walker A motif; other site
233413007199	ATP binding site [chemical binding]; other site
233413007200	Walker B motif; other site
233413007201	arginine finger; other site
233413007202	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
233413007203	Predicted integral membrane protein [Function unknown]; Region: COG5473
233413007204	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
233413007205	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
233413007206	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
233413007207	FtsX-like permease family; Region: FtsX; pfam02687
233413007208	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
233413007209	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
233413007210	Walker A/P-loop; other site
233413007211	ATP binding site [chemical binding]; other site
233413007212	Q-loop/lid; other site
233413007213	ABC transporter signature motif; other site
233413007214	Walker B; other site
233413007215	D-loop; other site
233413007216	H-loop/switch region; other site
233413007217	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413007218	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413007219	ligand binding site [chemical binding]; other site
233413007220	flexible hinge region; other site
233413007221	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413007222	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413007223	ligand binding site [chemical binding]; other site
233413007224	flexible hinge region; other site
233413007225	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
233413007226	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
233413007227	active site
233413007228	nucleophile elbow; other site
233413007229	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
233413007230	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
233413007231	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
233413007232	Putative amidoligase enzyme (DUF2126); Region: DUF2126; cl19857
233413007233	Putative amidoligase enzyme (DUF2126); Region: DUF2126; cl19857
233413007234	Uncharacterized conserved protein [Function unknown]; Region: COG2308
233413007235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
233413007236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
233413007237	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
233413007238	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
233413007239	Transglutaminase/protease-like homologues; Region: TGc; smart00460
233413007240	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801
233413007241	Predicted membrane protein [Function unknown]; Region: COG4129
233413007242	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
233413007243	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
233413007244	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
233413007245	dimer interface [polypeptide binding]; other site
233413007246	anticodon binding site; other site
233413007247	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
233413007248	homodimer interface [polypeptide binding]; other site
233413007249	motif 1; other site
233413007250	active site
233413007251	motif 2; other site
233413007252	GAD domain; Region: GAD; pfam02938
233413007253	motif 3; other site
233413007254	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
233413007255	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
233413007256	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
233413007257	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
233413007258	putative hydrophobic ligand binding site [chemical binding]; other site
233413007259	protein interface [polypeptide binding]; other site
233413007260	gate; other site
233413007261	Predicted metalloprotease [General function prediction only]; Region: COG2321
233413007262	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
233413007263	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
233413007264	active site
233413007265	metal binding site [ion binding]; metal-binding site
233413007266	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
233413007267	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413007268	FeS/SAM binding site; other site
233413007269	haloalkane dehalogenase; Provisional; Region: PRK03592
233413007270	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
233413007271	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
233413007272	dimer interface [polypeptide binding]; other site
233413007273	motif 1; other site
233413007274	active site
233413007275	motif 2; other site
233413007276	motif 3; other site
233413007277	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
233413007278	anticodon binding site; other site
233413007279	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
233413007280	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
233413007281	active site
233413007282	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
233413007283	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
233413007284	Zn2+ binding site [ion binding]; other site
233413007285	Mg2+ binding site [ion binding]; other site
233413007286	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
233413007287	synthetase active site [active]
233413007288	NTP binding site [chemical binding]; other site
233413007289	metal binding site [ion binding]; metal-binding site
233413007290	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
233413007291	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
233413007292	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413007293	active site
233413007294	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
233413007295	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
233413007296	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
233413007297	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
233413007298	Protein export membrane protein; Region: SecD_SecF; pfam02355
233413007299	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
233413007300	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
233413007301	MMPL family; Region: MMPL; cl14618
233413007302	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
233413007303	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
233413007304	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
233413007305	inhibitor-cofactor binding pocket; inhibition site
233413007306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413007307	catalytic residue [active]
233413007308	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
233413007309	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413007310	acyl-activating enzyme (AAE) consensus motif; other site
233413007311	AMP binding site [chemical binding]; other site
233413007312	active site
233413007313	CoA binding site [chemical binding]; other site
233413007314	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413007315	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
233413007316	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
233413007317	putative NAD(P) binding site [chemical binding]; other site
233413007318	active site
233413007319	putative substrate binding site [chemical binding]; other site
233413007320	PE family; Region: PE; pfam00934
233413007321	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
233413007322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413007323	Walker A motif; other site
233413007324	ATP binding site [chemical binding]; other site
233413007325	Walker B motif; other site
233413007326	arginine finger; other site
233413007327	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
233413007328	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
233413007329	RuvA N terminal domain; Region: RuvA_N; pfam01330
233413007330	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
233413007331	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
233413007332	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
233413007333	active site
233413007334	putative DNA-binding cleft [nucleotide binding]; other site
233413007335	dimer interface [polypeptide binding]; other site
233413007336	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
233413007337	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413007338	putative active site [active]
233413007339	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
233413007340	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
233413007341	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
233413007342	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
233413007343	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
233413007344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413007345	S-adenosylmethionine binding site [chemical binding]; other site
233413007346	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
233413007347	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413007348	hypothetical protein; Validated; Region: PRK00110
233413007349	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
233413007350	predicted active site [active]
233413007351	catalytic triad [active]
233413007352	acyl-CoA thioesterase II; Region: tesB; TIGR00189
233413007353	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
233413007354	active site
233413007355	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
233413007356	catalytic triad [active]
233413007357	dimer interface [polypeptide binding]; other site
233413007358	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
233413007359	active site
233413007360	multimer interface [polypeptide binding]; other site
233413007361	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
233413007362	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
233413007363	Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114
233413007364	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
233413007365	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413007366	PPE family; Region: PPE; pfam00823
233413007367	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413007368	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413007369	PE-PPE domain; Region: PE-PPE; pfam08237
233413007370	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
233413007371	nudix motif; other site
233413007372	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
233413007373	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
233413007374	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
233413007375	putative acyl-acceptor binding pocket; other site
233413007376	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
233413007377	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
233413007378	nucleotide binding site/active site [active]
233413007379	HIT family signature motif; other site
233413007380	catalytic residue [active]
233413007381	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
233413007382	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
233413007383	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
233413007384	active site
233413007385	dimer interface [polypeptide binding]; other site
233413007386	motif 1; other site
233413007387	motif 2; other site
233413007388	motif 3; other site
233413007389	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
233413007390	anticodon binding site; other site
233413007391	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
233413007392	phosphate binding site [ion binding]; other site
233413007393	PE family; Region: PE; pfam00934
233413007394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
233413007395	Predicted transcriptional regulator [Transcription]; Region: COG2345
233413007396	Helix-turn-helix domain; Region: HTH_20; pfam12840
233413007397	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
233413007398	Predicted transcriptional regulator [Transcription]; Region: COG2345
233413007399	Helix-turn-helix domain; Region: HTH_20; pfam12840
233413007400	putative DNA binding site [nucleotide binding]; other site
233413007401	putative Zn2+ binding site [ion binding]; other site
233413007402	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413007403	S-adenosylmethionine binding site [chemical binding]; other site
233413007404	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413007405	Ligand Binding Site [chemical binding]; other site
233413007406	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413007407	Ligand Binding Site [chemical binding]; other site
233413007408	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413007409	Ligand Binding Site [chemical binding]; other site
233413007410	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413007411	Ligand Binding Site [chemical binding]; other site
233413007412	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
233413007413	Peptidase family M50; Region: Peptidase_M50; pfam02163
233413007414	active site
233413007415	putative substrate binding region [chemical binding]; other site
233413007416	FOG: CBS domain [General function prediction only]; Region: COG0517
233413007417	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
233413007418	FOG: CBS domain [General function prediction only]; Region: COG0517
233413007419	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
233413007420	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
233413007421	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
233413007422	eRF1 domain 3; Region: eRF1_3; pfam03465
233413007423	SHS2 domain protein implicated in nucleic acid metabolism [General function prediction    only]; Region: COG1371
233413007424	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
233413007425	tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
233413007426	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
233413007427	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
233413007428	Fe binding site [ion binding]; other site
233413007429	PE family; Region: PE; pfam00934
233413007430	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227
233413007431	P-loop motif; other site
233413007432	ATP binding site [chemical binding]; other site
233413007433	Chloramphenicol (Cm) binding site [chemical binding]; other site
233413007434	catalytic residue [active]
233413007435	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
233413007436	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
233413007437	anti sigma factor interaction site; other site
233413007438	regulatory phosphorylation site [posttranslational modification]; other site
233413007439	hypothetical protein; Provisional; Region: PRK02237
233413007440	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413007441	dimerization interface [polypeptide binding]; other site
233413007442	putative DNA binding site [nucleotide binding]; other site
233413007443	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413007444	putative Zn2+ binding site [ion binding]; other site
233413007445	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
233413007446	putative metal binding site [ion binding]; other site
233413007447	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413007448	dimerization interface [polypeptide binding]; other site
233413007449	putative DNA binding site [nucleotide binding]; other site
233413007450	putative Zn2+ binding site [ion binding]; other site
233413007451	arsenical-resistance protein; Region: acr3; TIGR00832
233413007452	Low molecular weight phosphatase family; Region: LMWPc; cd00115
233413007453	active site
233413007454	nitrous-oxide reductase; Validated; Region: PRK02888
233413007455	Transposase, Mutator family; Region: Transposase_mut; cl19537
233413007456	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413007457	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
233413007458	Clp amino terminal domain; Region: Clp_N; pfam02861
233413007459	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
233413007460	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413007461	Coenzyme A binding pocket [chemical binding]; other site
233413007462	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
233413007463	hypothetical protein; Provisional; Region: PRK14059
233413007464	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413007465	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413007466	TAP-like protein; Region: Abhydrolase_4; pfam08386
233413007467	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
233413007468	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
233413007469	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413007470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413007471	S-adenosylmethionine binding site [chemical binding]; other site
233413007472	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
233413007473	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
233413007474	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413007475	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413007476	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
233413007477	substrate binding site [chemical binding]; other site
233413007478	active site
233413007479	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413007480	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
233413007481	substrate binding site [chemical binding]; other site
233413007482	oxyanion hole (OAH) forming residues; other site
233413007483	trimer interface [polypeptide binding]; other site
233413007484	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
233413007485	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
233413007486	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
233413007487	catalytic site [active]
233413007488	putative active site [active]
233413007489	putative substrate binding site [chemical binding]; other site
233413007490	Helicase and RNase D C-terminal; Region: HRDC; smart00341
233413007491	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
233413007492	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
233413007493	TPP-binding site; other site
233413007494	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
233413007495	PYR/PP interface [polypeptide binding]; other site
233413007496	dimer interface [polypeptide binding]; other site
233413007497	TPP binding site [chemical binding]; other site
233413007498	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
233413007499	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
233413007500	FOG: CBS domain [General function prediction only]; Region: COG0517
233413007501	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
233413007502	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
233413007503	transmembrane helices; other site
233413007504	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
233413007505	transmembrane helices; other site
233413007506	Citrate transporter; Region: CitMHS; pfam03600
233413007507	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
233413007508	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
233413007509	Walker A/P-loop; other site
233413007510	ATP binding site [chemical binding]; other site
233413007511	Q-loop/lid; other site
233413007512	ABC transporter signature motif; other site
233413007513	Walker B; other site
233413007514	D-loop; other site
233413007515	H-loop/switch region; other site
233413007516	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
233413007517	TRAM domain; Region: TRAM; cl01282
233413007518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413007519	S-adenosylmethionine binding site [chemical binding]; other site
233413007520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413007521	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
233413007522	K+ potassium transporter; Region: K_trans; cl15781
233413007523	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
233413007524	TrkA-N domain; Region: TrkA_N; pfam02254
233413007525	TrkA-C domain; Region: TrkA_C; pfam02080
233413007526	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
233413007527	TrkA-N domain; Region: TrkA_N; pfam02254
233413007528	TrkA-C domain; Region: TrkA_C; pfam02080
233413007529	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
233413007530	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
233413007531	generic binding surface II; other site
233413007532	ssDNA binding site; other site
233413007533	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
233413007534	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
233413007535	trimer interface [polypeptide binding]; other site
233413007536	active site
233413007537	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
233413007538	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
233413007539	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
233413007540	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
233413007541	active site
233413007542	dimerization interface [polypeptide binding]; other site
233413007543	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
233413007544	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
233413007545	nucleotide binding site [chemical binding]; other site
233413007546	RNA polymerase sigma factor; Provisional; Region: PRK05901
233413007547	Merozoite surface antigen 2c; Region: MSA-2c; pfam12238
233413007548	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
233413007549	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413007550	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
233413007551	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413007552	DNA binding residues [nucleotide binding]
233413007553	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
233413007554	homotrimer interaction site [polypeptide binding]; other site
233413007555	putative active site [active]
233413007556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
233413007557	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
233413007558	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
233413007559	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
233413007560	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
233413007561	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
233413007562	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413007563	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
233413007564	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413007565	DNA binding residues [nucleotide binding]
233413007566	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
233413007567	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
233413007568	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
233413007569	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
233413007570	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
233413007571	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
233413007572	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413007573	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413007574	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
233413007575	PAC2 family; Region: PAC2; pfam09754
233413007576	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413007577	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413007578	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
233413007579	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
233413007580	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
233413007581	heme-binding site [chemical binding]; other site
233413007582	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
233413007583	ATP cone domain; Region: ATP-cone; pfam03477
233413007584	LysM domain; Region: LysM; pfam01476
233413007585	LexA repressor; Validated; Region: PRK00215
233413007586	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
233413007587	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
233413007588	Catalytic site [active]
233413007589	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
233413007590	LGFP repeat; Region: LGFP; pfam08310
233413007591	LGFP repeat; Region: LGFP; pfam08310
233413007592	LGFP repeat; Region: LGFP; pfam08310
233413007593	LGFP repeat; Region: LGFP; pfam08310
233413007594	LGFP repeat; Region: LGFP; pfam08310
233413007595	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
233413007596	Integral membrane protein TerC family; Region: TerC; cl10468
233413007597	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413007598	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413007599	active site
233413007600	GTPases [General function prediction only]; Region: HflX; COG2262
233413007601	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
233413007602	HflX GTPase family; Region: HflX; cd01878
233413007603	G1 box; other site
233413007604	GTP/Mg2+ binding site [chemical binding]; other site
233413007605	Switch I region; other site
233413007606	G2 box; other site
233413007607	G3 box; other site
233413007608	Switch II region; other site
233413007609	G4 box; other site
233413007610	G5 box; other site
233413007611	diaminopimelate epimerase; Region: DapF; TIGR00652
233413007612	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
233413007613	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
233413007614	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
233413007615	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
233413007616	active site
233413007617	metal binding site [ion binding]; metal-binding site
233413007618	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
233413007619	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
233413007620	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
233413007621	Herpesvirus UL25 family; Region: Herpes_UL25; pfam01499
233413007622	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
233413007623	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
233413007624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413007625	FeS/SAM binding site; other site
233413007626	TRAM domain; Region: TRAM; cl01282
233413007627	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413007628	FeS/SAM binding site; other site
233413007629	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
233413007630	DNA recombination protein RecA; Reviewed; Region: recA; PRK09519
233413007631	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
233413007632	hexamer interface [polypeptide binding]; other site
233413007633	Walker A motif; other site
233413007634	ATP binding site [chemical binding]; other site
233413007635	Walker B motif; other site
233413007636	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
233413007637	protein-splicing catalytic site; other site
233413007638	thioester formation/cholesterol transfer; other site
233413007639	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
233413007640	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
233413007641	recA bacterial DNA recombination protein; Region: RecA; cl19152
233413007642	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
233413007643	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
233413007644	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
233413007645	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
233413007646	Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308
233413007647	PE family; Region: PE; pfam00934
233413007648	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
233413007649	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
233413007650	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413007651	non-specific DNA binding site [nucleotide binding]; other site
233413007652	salt bridge; other site
233413007653	sequence-specific DNA binding site [nucleotide binding]; other site
233413007654	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
233413007655	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413007656	Coenzyme A binding pocket [chemical binding]; other site
233413007657	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
233413007658	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
233413007659	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413007660	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
233413007661	Uncharacterized conserved protein [Function unknown]; Region: COG1359
233413007662	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
233413007663	classical (c) SDRs; Region: SDR_c; cd05233
233413007664	NAD(P) binding site [chemical binding]; other site
233413007665	active site
233413007666	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
233413007667	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
233413007668	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
233413007669	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
233413007670	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
233413007671	dimer interface [polypeptide binding]; other site
233413007672	active site
233413007673	catalytic residue [active]
233413007674	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
233413007675	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
233413007676	HsdM N-terminal domain; Region: HsdM_N; pfam12161
233413007677	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
233413007678	Methyltransferase domain; Region: Methyltransf_26; pfam13659
233413007679	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
233413007680	putative active site [active]
233413007681	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
233413007682	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
233413007683	putative active site [active]
233413007684	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
233413007685	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
233413007686	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
233413007687	Winged helix DNA-binding domain; Region: HTH_42; cl19833
233413007688	Winged helix DNA-binding domain; Region: HTH_42; cl19833
233413007689	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
233413007690	folate binding site [chemical binding]; other site
233413007691	NADP+ binding site [chemical binding]; other site
233413007692	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
233413007693	dimerization interface [polypeptide binding]; other site
233413007694	active site
233413007695	Dienelactone hydrolase family; Region: DLH; pfam01738
233413007696	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
233413007697	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
233413007698	classical (c) SDRs; Region: SDR_c; cd05233
233413007699	NAD(P) binding site [chemical binding]; other site
233413007700	active site
233413007701	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413007702	PPE family; Region: PPE; pfam00823
233413007703	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413007704	PE family; Region: PE; pfam00934
233413007705	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413007706	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413007707	PPE family; Region: PPE; pfam00823
233413007708	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413007709	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
233413007710	dihydrodipicolinate reductase; Provisional; Region: PRK00048
233413007711	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
233413007712	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
233413007713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413007714	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
233413007715	Coenzyme A binding pocket [chemical binding]; other site
233413007716	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
233413007717	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
233413007718	FMN-binding pocket [chemical binding]; other site
233413007719	flavin binding motif; other site
233413007720	phosphate binding motif [ion binding]; other site
233413007721	beta-alpha-beta structure motif; other site
233413007722	NAD binding pocket [chemical binding]; other site
233413007723	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413007724	catalytic loop [active]
233413007725	iron binding site [ion binding]; other site
233413007726	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
233413007727	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
233413007728	hydrophobic ligand binding site; other site
233413007729	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
233413007730	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413007731	putative DNA binding site [nucleotide binding]; other site
233413007732	putative Zn2+ binding site [ion binding]; other site
233413007733	AsnC family; Region: AsnC_trans_reg; pfam01037
233413007734	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
233413007735	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
233413007736	NAD(P) binding site [chemical binding]; other site
233413007737	hexamer interface [polypeptide binding]; other site
233413007738	putative active site [active]
233413007739	Nitronate monooxygenase; Region: NMO; pfam03060
233413007740	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
233413007741	FMN binding site [chemical binding]; other site
233413007742	substrate binding site [chemical binding]; other site
233413007743	putative catalytic residue [active]
233413007744	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
233413007745	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
233413007746	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
233413007747	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
233413007748	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
233413007749	oligomer interface [polypeptide binding]; other site
233413007750	RNA binding site [nucleotide binding]; other site
233413007751	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
233413007752	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
233413007753	RNase E interface [polypeptide binding]; other site
233413007754	trimer interface [polypeptide binding]; other site
233413007755	active site
233413007756	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
233413007757	putative nucleic acid binding region [nucleotide binding]; other site
233413007758	G-X-X-G motif; other site
233413007759	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
233413007760	RNA binding site [nucleotide binding]; other site
233413007761	domain interface; other site
233413007762	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
233413007763	16S/18S rRNA binding site [nucleotide binding]; other site
233413007764	S13e-L30e interaction site [polypeptide binding]; other site
233413007765	25S rRNA binding site [nucleotide binding]; other site
233413007766	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
233413007767	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
233413007768	active site
233413007769	Riboflavin kinase; Region: Flavokinase; pfam01687
233413007770	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
233413007771	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
233413007772	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
233413007773	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413007774	putative DNA binding site [nucleotide binding]; other site
233413007775	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
233413007776	FeoA domain; Region: FeoA; pfam04023
233413007777	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413007778	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413007779	active site
233413007780	lipid-transfer protein; Provisional; Region: PRK08256
233413007781	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
233413007782	active site
233413007783	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
233413007784	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
233413007785	Probable transposase; Region: OrfB_IS605; pfam01385
233413007786	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
233413007787	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
233413007788	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
233413007789	catalytic residues [active]
233413007790	catalytic nucleophile [active]
233413007791	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
233413007792	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
233413007793	RNA binding site [nucleotide binding]; other site
233413007794	active site
233413007795	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
233413007796	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
233413007797	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
233413007798	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
233413007799	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
233413007800	active site
233413007801	metal binding site [ion binding]; metal-binding site
233413007802	Uncharacterized conserved protein [Function unknown]; Region: COG4717
233413007803	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
233413007804	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
233413007805	Predicted acyl esterases [General function prediction only]; Region: COG2936
233413007806	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
233413007807	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
233413007808	Uncharacterized conserved protein [Function unknown]; Region: COG5586
233413007809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
233413007810	Integrase core domain; Region: rve; pfam00665
233413007811	Mb2833c, -, len: 133 aa. Equivalent to Rv2810c, len: 133 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 133 aa overlap). Probable transposase for IS1555, similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA TRANSPOSASE from Arthrobacter sp. TM1 (435 aa), FASTA scores: opt: 294, E(): 1.8e-13, (55.1% identity in 98 aa overlap); Q50440|TNPA INSERTION ELEMENT TNPR AND TNPA GENE from Mycobacterium smegmatis (413 aa), FASTA scores: opt: 274, E(): 4.7e-12, (56.25% identity in 96 aa overlap); etc.;PROBABLE TRANSPOSASE
233413007812	Helix-turn-helix domain; Region: HTH_28; pfam13518
233413007813	Winged helix-turn helix; Region: HTH_29; pfam13551
233413007814	Homeodomain-like domain; Region: HTH_32; pfam13565
233413007815	Integrase core domain; Region: rve; pfam00665
233413007816	Integrase core domain; Region: rve; pfam00665
233413007817	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
233413007818	Integrase core domain; Region: rve_3; pfam13683
233413007819	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
233413007820	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
233413007821	AAA domain; Region: AAA_22; pfam13401
233413007822	putative transposase OrfB; Reviewed; Region: PHA02517
233413007823	HTH-like domain; Region: HTH_21; pfam13276
233413007824	Integrase core domain; Region: rve; pfam00665
233413007825	Integrase core domain; Region: rve_3; pfam13683
233413007826	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
233413007827	Transposase; Region: HTH_Tnp_1; cl17663
233413007828	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
233413007829	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636
233413007830	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
233413007831	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662
233413007832	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663
233413007833	CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684
233413007834	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
233413007835	Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353
233413007836	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
233413007837	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
233413007838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293
233413007839	Uncharacterized conserved protein [Function unknown]; Region: COG2253
233413007840	Protein of unknown function (DUF2005); Region: DUF2005; pfam09407
233413007841	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
233413007842	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
233413007843	putative active site [active]
233413007844	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
233413007845	enoyl-CoA hydratase; Provisional; Region: PRK06190
233413007846	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413007847	substrate binding site [chemical binding]; other site
233413007848	oxyanion hole (OAH) forming residues; other site
233413007849	trimer interface [polypeptide binding]; other site
233413007850	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
233413007851	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
233413007852	Walker A/P-loop; other site
233413007853	ATP binding site [chemical binding]; other site
233413007854	Q-loop/lid; other site
233413007855	ABC transporter signature motif; other site
233413007856	Walker B; other site
233413007857	D-loop; other site
233413007858	H-loop/switch region; other site
233413007859	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
233413007860	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
233413007861	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
233413007862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413007863	dimer interface [polypeptide binding]; other site
233413007864	conserved gate region; other site
233413007865	putative PBP binding loops; other site
233413007866	ABC-ATPase subunit interface; other site
233413007867	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413007868	putative PBP binding loops; other site
233413007869	dimer interface [polypeptide binding]; other site
233413007870	ABC-ATPase subunit interface; other site
233413007871	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
233413007872	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
233413007873	putative efflux protein, MATE family; Region: matE; TIGR00797
233413007874	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
233413007875	DHH family; Region: DHH; pfam01368
233413007876	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
233413007877	translation initiation factor IF-2; Validated; Region: infB; PRK05306
233413007878	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
233413007879	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
233413007880	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
233413007881	G1 box; other site
233413007882	putative GEF interaction site [polypeptide binding]; other site
233413007883	GTP/Mg2+ binding site [chemical binding]; other site
233413007884	Switch I region; other site
233413007885	G2 box; other site
233413007886	G3 box; other site
233413007887	Switch II region; other site
233413007888	G4 box; other site
233413007889	G5 box; other site
233413007890	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
233413007891	Translation-initiation factor 2; Region: IF-2; pfam11987
233413007892	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
233413007893	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
233413007894	putative RNA binding cleft [nucleotide binding]; other site
233413007895	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
233413007896	NusA N-terminal domain; Region: NusA_N; pfam08529
233413007897	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
233413007898	RNA binding site [nucleotide binding]; other site
233413007899	homodimer interface [polypeptide binding]; other site
233413007900	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
233413007901	G-X-X-G motif; other site
233413007902	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
233413007903	G-X-X-G motif; other site
233413007904	Sm and related proteins; Region: Sm_like; cl00259
233413007905	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
233413007906	putative oligomer interface [polypeptide binding]; other site
233413007907	putative RNA binding site [nucleotide binding]; other site
233413007908	Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718
233413007909	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
233413007910	dinuclear metal binding motif [ion binding]; other site
233413007911	prolyl-tRNA synthetase; Provisional; Region: PRK09194
233413007912	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
233413007913	dimer interface [polypeptide binding]; other site
233413007914	motif 1; other site
233413007915	active site
233413007916	motif 2; other site
233413007917	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
233413007918	putative deacylase active site [active]
233413007919	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
233413007920	anticodon binding site; other site
233413007921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413007922	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413007923	putative substrate translocation pore; other site
233413007924	siroheme synthase; Provisional; Region: cysG; PRK10637
233413007925	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
233413007926	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
233413007927	active site
233413007928	SAM binding site [chemical binding]; other site
233413007929	homodimer interface [polypeptide binding]; other site
233413007930	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
233413007931	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413007932	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
233413007933	catalytic triad [active]
233413007934	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
233413007935	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
233413007936	homodimer interface [polypeptide binding]; other site
233413007937	Walker A motif; other site
233413007938	ATP binding site [chemical binding]; other site
233413007939	hydroxycobalamin binding site [chemical binding]; other site
233413007940	Walker B motif; other site
233413007941	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
233413007942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413007943	Walker A motif; other site
233413007944	ATP binding site [chemical binding]; other site
233413007945	Walker B motif; other site
233413007946	arginine finger; other site
233413007947	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
233413007948	metal ion-dependent adhesion site (MIDAS); other site
233413007949	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
233413007950	Predicted dehydrogenase [General function prediction only]; Region: COG0579
233413007951	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
233413007952	PE family; Region: PE; pfam00934
233413007953	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
233413007954	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413007955	mycothione reductase; Reviewed; Region: PRK07846
233413007956	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413007957	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413007958	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
233413007959	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
233413007960	short chain dehydrogenase; Provisional; Region: PRK06057
233413007961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413007962	NAD(P) binding site [chemical binding]; other site
233413007963	active site
233413007964	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
233413007965	NAD(P) binding site [chemical binding]; other site
233413007966	catalytic residues [active]
233413007967	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
233413007968	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
233413007969	catalytic triad [active]
233413007970	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
233413007971	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
233413007972	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
233413007973	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
233413007974	active site
233413007975	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
233413007976	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413007977	putative active site [active]
233413007978	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
233413007979	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
233413007980	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
233413007981	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
233413007982	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
233413007983	Predicted acetyltransferase [General function prediction only]; Region: COG3393
233413007984	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
233413007985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
233413007986	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
233413007987	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
233413007988	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
233413007989	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
233413007990	active site
233413007991	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
233413007992	protein binding site [polypeptide binding]; other site
233413007993	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
233413007994	putative substrate binding region [chemical binding]; other site
233413007995	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
233413007996	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
233413007997	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
233413007998	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
233413007999	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413008000	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413008001	putative active site [active]
233413008002	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
233413008003	Fasciclin domain; Region: Fasciclin; pfam02469
233413008004	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
233413008005	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
233413008006	catalytic residues [active]
233413008007	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
233413008008	Fasciclin domain; Region: Fasciclin; pfam02469
233413008009	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
233413008010	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
233413008011	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
233413008012	catalytic residues [active]
233413008013	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
233413008014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413008015	FeS/SAM binding site; other site
233413008016	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
233413008017	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
233413008018	hinge region; other site
233413008019	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
233413008020	putative nucleotide binding site [chemical binding]; other site
233413008021	uridine monophosphate binding site [chemical binding]; other site
233413008022	homohexameric interface [polypeptide binding]; other site
233413008023	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413008024	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413008025	DNA binding site [nucleotide binding]
233413008026	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
233413008027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
233413008028	Probable transposase; Region: OrfB_IS605; pfam01385
233413008029	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
233413008030	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
233413008031	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
233413008032	catalytic residues [active]
233413008033	catalytic nucleophile [active]
233413008034	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
233413008035	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413008036	amidase; Provisional; Region: PRK07869
233413008037	elongation factor Ts; Provisional; Region: tsf; PRK09377
233413008038	UBA/TS-N domain; Region: UBA; pfam00627
233413008039	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
233413008040	rRNA interaction site [nucleotide binding]; other site
233413008041	S8 interaction site; other site
233413008042	putative laminin-1 binding site; other site
233413008043	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
233413008044	Peptidase family M23; Region: Peptidase_M23; pfam01551
233413008045	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008046	PPE family; Region: PPE; pfam00823
233413008047	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413008048	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
233413008049	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
233413008050	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
233413008051	active site
233413008052	DNA binding site [nucleotide binding]
233413008053	Int/Topo IB signature motif; other site
233413008054	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
233413008055	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
233413008056	FAD binding pocket [chemical binding]; other site
233413008057	FAD binding motif [chemical binding]; other site
233413008058	phosphate binding motif [ion binding]; other site
233413008059	NAD binding pocket [chemical binding]; other site
233413008060	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
233413008061	DNA protecting protein DprA; Region: dprA; TIGR00732
233413008062	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
233413008063	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
233413008064	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
233413008065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
233413008066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413008067	Walker A motif; other site
233413008068	ATP binding site [chemical binding]; other site
233413008069	Walker B motif; other site
233413008070	arginine finger; other site
233413008071	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
233413008072	hypothetical protein; Reviewed; Region: PRK12497
233413008073	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
233413008074	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
233413008075	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
233413008076	putative molybdopterin cofactor binding site [chemical binding]; other site
233413008077	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
233413008078	putative molybdopterin cofactor binding site; other site
233413008079	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
233413008080	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
233413008081	RNA/DNA hybrid binding site [nucleotide binding]; other site
233413008082	active site
233413008083	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
233413008084	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
233413008085	Catalytic site [active]
233413008086	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
233413008087	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
233413008088	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
233413008089	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
233413008090	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
233413008091	RimM N-terminal domain; Region: RimM; pfam01782
233413008092	hypothetical protein; Provisional; Region: PRK02821
233413008093	G-X-X-G motif; other site
233413008094	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
233413008095	ribosomal protein S16; Region: S16; TIGR00002
233413008096	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
233413008097	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
233413008098	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
233413008099	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413008100	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008101	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
233413008102	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
233413008103	active site
233413008104	putative substrate binding pocket [chemical binding]; other site
233413008105	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413008106	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413008107	active site
233413008108	ATP binding site [chemical binding]; other site
233413008109	substrate binding site [chemical binding]; other site
233413008110	activation loop (A-loop); other site
233413008111	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
233413008112	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
233413008113	active site
233413008114	signal recognition particle protein; Provisional; Region: PRK10867
233413008115	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
233413008116	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
233413008117	P loop; other site
233413008118	GTP binding site [chemical binding]; other site
233413008119	Signal peptide binding domain; Region: SRP_SPB; pfam02978
233413008120	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
233413008121	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413008122	ATP binding site [chemical binding]; other site
233413008123	putative Mg++ binding site [ion binding]; other site
233413008124	PII uridylyl-transferase; Provisional; Region: PRK03381
233413008125	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
233413008126	metal binding triad; other site
233413008127	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
233413008128	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
233413008129	Zn2+ binding site [ion binding]; other site
233413008130	Mg2+ binding site [ion binding]; other site
233413008131	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
233413008132	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
233413008133	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
233413008134	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
233413008135	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
233413008136	SRP54-type protein, GTPase domain; Region: SRP54; pfam00448
233413008137	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
233413008138	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
233413008139	Walker A/P-loop; other site
233413008140	ATP binding site [chemical binding]; other site
233413008141	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
233413008142	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
233413008143	ABC transporter signature motif; other site
233413008144	Walker B; other site
233413008145	D-loop; other site
233413008146	H-loop/switch region; other site
233413008147	acylphosphatase; Provisional; Region: PRK14422
233413008148	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
233413008149	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
233413008150	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
233413008151	DNA binding site [nucleotide binding]
233413008152	catalytic residue [active]
233413008153	H2TH interface [polypeptide binding]; other site
233413008154	putative catalytic residues [active]
233413008155	turnover-facilitating residue; other site
233413008156	intercalation triad [nucleotide binding]; other site
233413008157	8OG recognition residue [nucleotide binding]; other site
233413008158	putative reading head residues; other site
233413008159	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
233413008160	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
233413008161	ribonuclease III; Reviewed; Region: rnc; PRK00102
233413008162	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
233413008163	dimerization interface [polypeptide binding]; other site
233413008164	active site
233413008165	metal binding site [ion binding]; metal-binding site
233413008166	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
233413008167	dsRNA binding site [nucleotide binding]; other site
233413008168	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
233413008169	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
233413008170	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
233413008171	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
233413008172	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413008173	acyl-CoA synthetase; Validated; Region: PRK05850
233413008174	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413008175	acyl-activating enzyme (AAE) consensus motif; other site
233413008176	active site
233413008177	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413008178	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413008179	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413008180	active site
233413008181	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
233413008182	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413008183	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
233413008184	NADP binding site [chemical binding]; other site
233413008185	short chain dehydrogenase; Region: adh_short; pfam00106
233413008186	active site
233413008187	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413008188	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413008189	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413008190	active site
233413008191	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
233413008192	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
233413008193	short chain dehydrogenase; Region: adh_short; pfam00106
233413008194	NADP binding site [chemical binding]; other site
233413008195	active site
233413008196	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413008197	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413008198	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413008199	active site
233413008200	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
233413008201	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413008202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413008203	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413008204	Enoylreductase; Region: PKS_ER; smart00829
233413008205	NAD(P) binding site [chemical binding]; other site
233413008206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413008207	short chain dehydrogenase; Region: adh_short; pfam00106
233413008208	NAD(P) binding site [chemical binding]; other site
233413008209	active site
233413008210	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413008211	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413008212	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413008213	active site
233413008214	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413008215	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413008216	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
233413008217	putative NADP binding site [chemical binding]; other site
233413008218	short chain dehydrogenase; Region: adh_short; pfam00106
233413008219	active site
233413008220	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413008221	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413008222	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413008223	active site
233413008224	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413008225	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413008226	Condensation domain; Region: Condensation; cl19241
233413008227	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
233413008228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413008229	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
233413008230	Walker A/P-loop; other site
233413008231	ATP binding site [chemical binding]; other site
233413008232	Q-loop/lid; other site
233413008233	ABC transporter signature motif; other site
233413008234	Walker B; other site
233413008235	D-loop; other site
233413008236	H-loop/switch region; other site
233413008237	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
233413008238	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
233413008239	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
233413008240	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
233413008241	acyltransferase PapA5; Provisional; Region: PRK09294
233413008242	Condensation domain; Region: Condensation; cl19241
233413008243	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413008244	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413008245	active site
233413008246	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
233413008247	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413008248	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413008249	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413008250	Enoylreductase; Region: PKS_ER; smart00829
233413008251	NAD(P) binding site [chemical binding]; other site
233413008252	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413008253	NAD(P) binding site [chemical binding]; other site
233413008254	short chain dehydrogenase; Region: adh_short; pfam00106
233413008255	active site
233413008256	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413008257	acyl-CoA synthetase; Validated; Region: PRK05850
233413008258	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413008259	acyl-activating enzyme (AAE) consensus motif; other site
233413008260	active site
233413008261	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413008262	MMPL family; Region: MMPL; pfam03176
233413008263	MMPL family; Region: MMPL; cl14618
233413008264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
233413008265	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
233413008266	DNA-binding interface [nucleotide binding]; DNA binding site
233413008267	Integrase core domain; Region: rve; pfam00665
233413008268	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
233413008269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
233413008270	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
233413008271	Erythronolide synthase docking; Region: Docking; pfam08990
233413008272	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413008273	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413008274	active site
233413008275	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413008276	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413008277	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413008278	Enoylreductase; Region: PKS_ER; smart00829
233413008279	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413008280	NAD(P) binding site [chemical binding]; other site
233413008281	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
233413008282	short chain dehydrogenase; Region: adh_short; pfam00106
233413008283	putative NADP binding site [chemical binding]; other site
233413008284	active site
233413008285	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413008286	acyl-CoA synthetase; Validated; Region: PRK06060
233413008287	Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919
233413008288	dimer interface [polypeptide binding]; other site
233413008289	acyl-activating enzyme (AAE) consensus motif; other site
233413008290	putative active site [active]
233413008291	putative AMP binding site [chemical binding]; other site
233413008292	putative CoA binding site [chemical binding]; other site
233413008293	chemical substrate binding site [chemical binding]; other site
233413008294	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413008295	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
233413008296	acyl-CoA synthetase; Validated; Region: PRK05850
233413008297	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413008298	acyl-activating enzyme (AAE) consensus motif; other site
233413008299	active site
233413008300	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413008301	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413008302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413008303	S-adenosylmethionine binding site [chemical binding]; other site
233413008304	Uncharacterized conserved protein [Function unknown]; Region: COG3268
233413008305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413008306	S-adenosylmethionine binding site [chemical binding]; other site
233413008307	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
233413008308	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
233413008309	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
233413008310	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
233413008311	metal-binding site
233413008312	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
233413008313	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
233413008314	Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510
233413008315	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
233413008316	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
233413008317	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
233413008318	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
233413008319	active site
233413008320	TDP-binding site; other site
233413008321	acceptor substrate-binding pocket; other site
233413008322	Predicted permease; Region: DUF318; pfam03773
233413008323	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
233413008324	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
233413008325	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
233413008326	putative active site [active]
233413008327	putative substrate binding site [chemical binding]; other site
233413008328	putative cosubstrate binding site; other site
233413008329	catalytic site [active]
233413008330	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
233413008331	active site
233413008332	(T/H)XGH motif; other site
233413008333	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413008334	S-adenosylmethionine binding site [chemical binding]; other site
233413008335	pyruvate carboxylase; Reviewed; Region: PRK12999
233413008336	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
233413008337	ATP-grasp domain; Region: ATP-grasp_4; cl17255
233413008338	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
233413008339	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
233413008340	active site
233413008341	catalytic residues [active]
233413008342	metal binding site [ion binding]; metal-binding site
233413008343	homodimer binding site [polypeptide binding]; other site
233413008344	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
233413008345	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
233413008346	carboxyltransferase (CT) interaction site; other site
233413008347	biotinylation site [posttranslational modification]; other site
233413008348	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
233413008349	putative active site [active]
233413008350	redox center [active]
233413008351	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
233413008352	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
233413008353	catalytic residues [active]
233413008354	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413008355	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413008356	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
233413008357	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
233413008358	active site
233413008359	catalytic tetrad [active]
233413008360	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
233413008361	ATP-dependent DNA helicase RecG; Region: recG; TIGR00643
233413008362	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
233413008363	generic binding surface II; other site
233413008364	ssDNA binding site; other site
233413008365	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413008366	ATP binding site [chemical binding]; other site
233413008367	putative Mg++ binding site [ion binding]; other site
233413008368	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413008369	nucleotide binding region [chemical binding]; other site
233413008370	ATP-binding site [chemical binding]; other site
233413008371	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
233413008372	DAK2 domain; Region: Dak2; cl03685
233413008373	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
233413008374	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
233413008375	ligand binding site [chemical binding]; other site
233413008376	active site
233413008377	UGI interface [polypeptide binding]; other site
233413008378	catalytic site [active]
233413008379	thiamine monophosphate kinase; Provisional; Region: PRK05731
233413008380	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
233413008381	ATP binding site [chemical binding]; other site
233413008382	dimerization interface [polypeptide binding]; other site
233413008383	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
233413008384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
233413008385	Probable transposase; Region: OrfB_IS605; pfam01385
233413008386	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
233413008387	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
233413008388	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
233413008389	catalytic residues [active]
233413008390	catalytic nucleophile [active]
233413008391	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
233413008392	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
233413008393	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
233413008394	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
233413008395	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
233413008396	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
233413008397	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
233413008398	Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920
233413008399	polyphosphate kinase; Provisional; Region: PRK05443
233413008400	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
233413008401	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
233413008402	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
233413008403	putative domain interface [polypeptide binding]; other site
233413008404	putative active site [active]
233413008405	catalytic site [active]
233413008406	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
233413008407	putative active site [active]
233413008408	catalytic site [active]
233413008409	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
233413008410	active site
233413008411	Ap6A binding site [chemical binding]; other site
233413008412	nudix motif; other site
233413008413	metal binding site [ion binding]; metal-binding site
233413008414	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413008415	catalytic core [active]
233413008416	histone-like DNA-binding protein HU; Region: HU; cd13831
233413008417	dimer interface [polypeptide binding]; other site
233413008418	DNA binding site [nucleotide binding]
233413008419	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
233413008420	substrate binding site [chemical binding]; other site
233413008421	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
233413008422	substrate binding site [chemical binding]; other site
233413008423	ligand binding site [chemical binding]; other site
233413008424	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
233413008425	Transcriptional regulator [Transcription]; Region: IclR; COG1414
233413008426	Bacterial transcriptional regulator; Region: IclR; pfam01614
233413008427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413008428	S-adenosylmethionine binding site [chemical binding]; other site
233413008429	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
233413008430	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
233413008431	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
233413008432	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
233413008433	active site
233413008434	HIGH motif; other site
233413008435	KMSKS motif; other site
233413008436	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
233413008437	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
233413008438	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
233413008439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413008440	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413008441	putative substrate translocation pore; other site
233413008442	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
233413008443	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
233413008444	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
233413008445	ligand binding site [chemical binding]; other site
233413008446	NAD binding site [chemical binding]; other site
233413008447	dimerization interface [polypeptide binding]; other site
233413008448	catalytic site [active]
233413008449	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
233413008450	putative L-serine binding site [chemical binding]; other site
233413008451	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
233413008452	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413008453	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
233413008454	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413008455	phosphorylation site [posttranslational modification]
233413008456	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
233413008457	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
233413008458	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
233413008459	ketol-acid reductoisomerase; Provisional; Region: PRK05479
233413008460	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
233413008461	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
233413008462	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
233413008463	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
233413008464	putative valine binding site [chemical binding]; other site
233413008465	dimer interface [polypeptide binding]; other site
233413008466	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
233413008467	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
233413008468	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
233413008469	PYR/PP interface [polypeptide binding]; other site
233413008470	dimer interface [polypeptide binding]; other site
233413008471	TPP binding site [chemical binding]; other site
233413008472	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
233413008473	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
233413008474	TPP-binding site [chemical binding]; other site
233413008475	dimer interface [polypeptide binding]; other site
233413008476	Bacterial PH domain; Region: bPH_6; pfam10756
233413008477	Predicted membrane protein [Function unknown]; Region: COG2259
233413008478	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
233413008479	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
233413008480	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
233413008481	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
233413008482	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
233413008483	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
233413008484	GatB domain; Region: GatB_Yqey; pfam02637
233413008485	6-phosphofructokinase; Provisional; Region: PRK03202
233413008486	active site
233413008487	ADP/pyrophosphate binding site [chemical binding]; other site
233413008488	dimerization interface [polypeptide binding]; other site
233413008489	allosteric effector site; other site
233413008490	fructose-1,6-bisphosphate binding site; other site
233413008491	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
233413008492	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
233413008493	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
233413008494	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
233413008495	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
233413008496	nucleotide binding pocket [chemical binding]; other site
233413008497	K-X-D-G motif; other site
233413008498	catalytic site [active]
233413008499	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
233413008500	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
233413008501	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
233413008502	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
233413008503	Dimer interface [polypeptide binding]; other site
233413008504	Cobalamin-independent synthase, Catalytic domain; Region: Meth_synt_2; pfam01717
233413008505	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413008506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
233413008507	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008508	PPE family; Region: PPE; pfam00823
233413008509	similar to PE family protein; Mb3044c, PE27A, len: 28 aa. Equivalent to Rv3018A, len: 28 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 28 aa overlap). Member of M. tuberculosis PE family, most similar to Rv0285 (102 aa), FASTA scores: opt: 147, E(): 3.5e-05, (92.85% identity in 28 aa overlap); etc.
233413008510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
233413008511	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008512	PPE family; Region: PPE; pfam00823
233413008513	PE family; Region: PE; pfam00934
233413008514	Transposase, Mutator family; Region: Transposase_mut; pfam00872
233413008515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413008516	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
233413008517	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
233413008518	Ligand Binding Site [chemical binding]; other site
233413008519	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
233413008520	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413008521	catalytic residue [active]
233413008522	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
233413008523	putative acyl-acceptor binding pocket; other site
233413008524	Putative hemolysin [General function prediction only]; Region: COG3176
233413008525	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
233413008526	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
233413008527	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
233413008528	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
233413008529	Ligand binding site [chemical binding]; other site
233413008530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413008531	S-adenosylmethionine binding site [chemical binding]; other site
233413008532	Uncharacterized conserved protein [Function unknown]; Region: COG1543
233413008533	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
233413008534	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
233413008535	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
233413008536	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
233413008537	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
233413008538	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
233413008539	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
233413008540	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
233413008541	trimer interface [polypeptide binding]; other site
233413008542	active site
233413008543	substrate binding site [chemical binding]; other site
233413008544	CoA binding site [chemical binding]; other site
233413008545	FOG: WD40-like repeat [Function unknown]; Region: COG1520
233413008546	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
233413008547	active site
233413008548	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
233413008549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413008550	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413008551	S-adenosylmethionine binding site [chemical binding]; other site
233413008552	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413008553	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
233413008554	substrate binding site [chemical binding]; other site
233413008555	oxyanion hole (OAH) forming residues; other site
233413008556	trimer interface [polypeptide binding]; other site
233413008557	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
233413008558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413008559	Walker A/P-loop; other site
233413008560	ATP binding site [chemical binding]; other site
233413008561	Q-loop/lid; other site
233413008562	ABC transporter signature motif; other site
233413008563	Walker B; other site
233413008564	D-loop; other site
233413008565	H-loop/switch region; other site
233413008566	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
233413008567	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
233413008568	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
233413008569	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413008570	motif II; other site
233413008571	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
233413008572	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
233413008573	D-pathway; other site
233413008574	Putative ubiquinol binding site [chemical binding]; other site
233413008575	Low-spin heme (heme b) binding site [chemical binding]; other site
233413008576	Putative water exit pathway; other site
233413008577	Binuclear center (heme o3/CuB) [ion binding]; other site
233413008578	K-pathway; other site
233413008579	Putative proton exit pathway; other site
233413008580	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
233413008581	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
233413008582	siderophore binding site; other site
233413008583	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
233413008584	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
233413008585	putative NAD(P) binding site [chemical binding]; other site
233413008586	putative substrate binding site [chemical binding]; other site
233413008587	catalytic Zn binding site [ion binding]; other site
233413008588	structural Zn binding site [ion binding]; other site
233413008589	dimer interface [polypeptide binding]; other site
233413008590	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
233413008591	chaperone protein DnaJ; Provisional; Region: PRK14289
233413008592	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
233413008593	dimer interface [polypeptide binding]; other site
233413008594	putative radical transfer pathway; other site
233413008595	diiron center [ion binding]; other site
233413008596	tyrosyl radical; other site
233413008597	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413008598	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
233413008599	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413008600	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008601	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
233413008602	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
233413008603	Class I ribonucleotide reductase; Region: RNR_I; cd01679
233413008604	active site
233413008605	dimer interface [polypeptide binding]; other site
233413008606	catalytic residues [active]
233413008607	effector binding site; other site
233413008608	R2 peptide binding site; other site
233413008609	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
233413008610	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
233413008611	catalytic residues [active]
233413008612	Predicted flavoprotein [General function prediction only]; Region: COG0431
233413008613	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413008614	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008615	DNA polymerase IV; Validated; Region: PRK03352
233413008616	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
233413008617	active site
233413008618	DNA binding site [nucleotide binding]
233413008619	short chain dehydrogenase; Provisional; Region: PRK05650
233413008620	classical (c) SDRs; Region: SDR_c; cd05233
233413008621	NAD(P) binding site [chemical binding]; other site
233413008622	active site
233413008623	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413008624	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008625	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413008626	Transcriptional regulators [Transcription]; Region: FadR; COG2186
233413008627	DNA-binding site [nucleotide binding]; DNA binding site
233413008628	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
233413008629	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
233413008630	Transcriptional regulators [Transcription]; Region: FadR; COG2186
233413008631	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
233413008632	DNA-binding site [nucleotide binding]; DNA binding site
233413008633	FCD domain; Region: FCD; pfam07729
233413008634	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413008635	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413008636	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413008637	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413008638	active site
233413008639	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413008640	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
233413008641	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
233413008642	DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675
233413008643	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
233413008644	active site
233413008645	DNA binding site [nucleotide binding]
233413008646	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
233413008647	DNA binding site [nucleotide binding]
233413008648	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
233413008649	Carbon starvation protein CstA; Region: CstA; pfam02554
233413008650	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
233413008651	Predicted membrane protein [Function unknown]; Region: COG2259
233413008652	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
233413008653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
233413008654	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008655	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413008656	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
233413008657	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
233413008658	active site
233413008659	substrate binding site [chemical binding]; other site
233413008660	metal binding site [ion binding]; metal-binding site
233413008661	camphor resistance protein CrcB; Provisional; Region: PRK14216
233413008662	camphor resistance protein CrcB; Provisional; Region: PRK14228
233413008663	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
233413008664	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
233413008665	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413008666	Uncharacterized conserved protein [Function unknown]; Region: COG3189
233413008667	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413008668	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413008669	active site
233413008670	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
233413008671	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
233413008672	putative hydrophobic ligand binding site [chemical binding]; other site
233413008673	protein interface [polypeptide binding]; other site
233413008674	gate; other site
233413008675	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
233413008676	Sulfatase; Region: Sulfatase; pfam00884
233413008677	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
233413008678	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
233413008679	Catalytic domain of Protein Kinases; Region: PKc; cd00180
233413008680	active site
233413008681	ATP binding site [chemical binding]; other site
233413008682	substrate binding site [chemical binding]; other site
233413008683	activation loop (A-loop); other site
233413008684	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
233413008685	AAA ATPase domain; Region: AAA_16; pfam13191
233413008686	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970
233413008687	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
233413008688	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
233413008689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
233413008690	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413008691	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
233413008692	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
233413008693	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413008694	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
233413008695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413008696	NAD(P) binding site [chemical binding]; other site
233413008697	active site
233413008698	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
233413008699	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
233413008700	NAD binding site [chemical binding]; other site
233413008701	catalytic Zn binding site [ion binding]; other site
233413008702	substrate binding site [chemical binding]; other site
233413008703	structural Zn binding site [ion binding]; other site
233413008704	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413008705	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413008706	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413008707	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413008708	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
233413008709	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
233413008710	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413008711	acyl-activating enzyme (AAE) consensus motif; other site
233413008712	AMP binding site [chemical binding]; other site
233413008713	active site
233413008714	CoA binding site [chemical binding]; other site
233413008715	SPFH domain / Band 7 family; Region: Band_7; pfam01145
233413008716	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
233413008717	Patatin-like phospholipase; Region: Patatin; pfam01734
233413008718	nucleophile elbow; other site
233413008719	Protein of unknown function (DUF808); Region: DUF808; cl01002
233413008720	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
233413008721	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413008722	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413008723	active site
233413008724	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413008725	dimerization interface [polypeptide binding]; other site
233413008726	putative DNA binding site [nucleotide binding]; other site
233413008727	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413008728	putative Zn2+ binding site [ion binding]; other site
233413008729	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
233413008730	PE family; Region: PE; pfam00934
233413008731	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413008732	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413008733	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413008734	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
233413008735	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
233413008736	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
233413008737	SmpB-tmRNA interface; other site
233413008738	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
233413008739	FtsX-like permease family; Region: FtsX; pfam02687
233413008740	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
233413008741	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413008742	Walker A/P-loop; other site
233413008743	ATP binding site [chemical binding]; other site
233413008744	Q-loop/lid; other site
233413008745	ABC transporter signature motif; other site
233413008746	Walker B; other site
233413008747	D-loop; other site
233413008748	H-loop/switch region; other site
233413008749	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
233413008750	Mechanosensitive ion channel; Region: MS_channel; pfam00924
233413008751	peptide chain release factor 2; Validated; Region: prfB; PRK00578
233413008752	This domain is found in peptide chain release factors; Region: PCRF; smart00937
233413008753	RF-1 domain; Region: RF-1; pfam00472
233413008754	ferredoxin-NADP+ reductase; Region: PLN02852
233413008755	Bacterial protein of unknown function (DUF871); Region: DUF871; cl19843
233413008756	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413008757	FAD binding domain; Region: FAD_binding_4; pfam01565
233413008758	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
233413008759	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
233413008760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413008761	FeS/SAM binding site; other site
233413008762	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
233413008763	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
233413008764	aromatic arch; other site
233413008765	DCoH dimer interaction site [polypeptide binding]; other site
233413008766	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
233413008767	DCoH tetramer interaction site [polypeptide binding]; other site
233413008768	substrate binding site [chemical binding]; other site
233413008769	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
233413008770	trimer interface [polypeptide binding]; other site
233413008771	dimer interface [polypeptide binding]; other site
233413008772	putative active site [active]
233413008773	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
233413008774	MoaE interaction surface [polypeptide binding]; other site
233413008775	MoeB interaction surface [polypeptide binding]; other site
233413008776	thiocarboxylated glycine; other site
233413008777	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
233413008778	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
233413008779	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
233413008780	nucleoside/Zn binding site; other site
233413008781	dimer interface [polypeptide binding]; other site
233413008782	catalytic motif [active]
233413008783	Transposase, Mutator family; Region: Transposase_mut; pfam00872
233413008784	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413008785	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
233413008786	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
233413008787	ATP binding site [chemical binding]; other site
233413008788	substrate interface [chemical binding]; other site
233413008789	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
233413008790	active site residue [active]
233413008791	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
233413008792	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
233413008793	active site residue [active]
233413008794	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
233413008795	active site residue [active]
233413008796	Cytochrome P450; Region: p450; cl12078
233413008797	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
233413008798	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
233413008799	DNA binding site [nucleotide binding]
233413008800	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008801	PPE family; Region: PPE; pfam00823
233413008802	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
233413008803	Integrase core domain; Region: rve; pfam00665
233413008804	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
233413008805	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413008806	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413008807	Nitroreductase family; Region: Nitroreductase; pfam00881
233413008808	dimer interface [polypeptide binding]; other site
233413008809	Nitroreductase family; Region: Nitroreductase; pfam00881
233413008810	dimer interface [polypeptide binding]; other site
233413008811	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
233413008812	GAF domain; Region: GAF_3; pfam13492
233413008813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
233413008814	Histidine kinase; Region: HisKA_3; pfam07730
233413008815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413008816	ATP binding site [chemical binding]; other site
233413008817	Mg2+ binding site [ion binding]; other site
233413008818	G-X-G motif; other site
233413008819	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
233413008820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413008821	active site
233413008822	phosphorylation site [posttranslational modification]
233413008823	intermolecular recognition site; other site
233413008824	dimerization interface [polypeptide binding]; other site
233413008825	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
233413008826	DNA binding residues [nucleotide binding]
233413008827	dimerization interface [polypeptide binding]; other site
233413008828	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
233413008829	Ligand Binding Site [chemical binding]; other site
233413008830	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008831	PPE family; Region: PPE; pfam00823
233413008832	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413008833	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008834	PPE family; Region: PPE; pfam00823
233413008835	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413008836	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
233413008837	active site
233413008838	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
233413008839	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413008840	FeS/SAM binding site; other site
233413008841	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413008842	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413008843	active site
233413008844	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413008845	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413008846	active site
233413008847	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
233413008848	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
233413008849	NAD(P) binding site [chemical binding]; other site
233413008850	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413008851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413008852	active site
233413008853	phosphorylation site [posttranslational modification]
233413008854	intermolecular recognition site; other site
233413008855	dimerization interface [polypeptide binding]; other site
233413008856	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008857	PPE family; Region: PPE; pfam00823
233413008858	NADH dehydrogenase subunit A; Validated; Region: PRK07928
233413008859	NADH dehydrogenase subunit B; Validated; Region: PRK06411
233413008860	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
233413008861	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
233413008862	NADH dehydrogenase subunit D; Validated; Region: PRK06075
233413008863	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
233413008864	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
233413008865	putative dimer interface [polypeptide binding]; other site
233413008866	[2Fe-2S] cluster binding site [ion binding]; other site
233413008867	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
233413008868	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
233413008869	SLBB domain; Region: SLBB; pfam10531
233413008870	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
233413008871	NADH dehydrogenase subunit G; Validated; Region: PRK07860
233413008872	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413008873	catalytic loop [active]
233413008874	iron binding site [ion binding]; other site
233413008875	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
233413008876	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
233413008877	[4Fe-4S] binding site [ion binding]; other site
233413008878	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
233413008879	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
233413008880	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
233413008881	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
233413008882	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
233413008883	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
233413008884	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
233413008885	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
233413008886	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
233413008887	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
233413008888	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
233413008889	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
233413008890	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
233413008891	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008892	PPE family; Region: PPE; pfam00823
233413008893	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008894	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008895	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008896	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008897	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008898	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008899	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413008900	PPE family; Region: PPE; pfam00823
233413008901	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008902	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008903	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008904	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008905	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008906	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008907	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008908	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413008909	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
233413008910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008911	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
233413008912	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
233413008913	[2Fe-2S] cluster binding site [ion binding]; other site
233413008914	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
233413008915	putative alpha subunit interface [polypeptide binding]; other site
233413008916	putative active site [active]
233413008917	putative substrate binding site [chemical binding]; other site
233413008918	Fe binding site [ion binding]; other site
233413008919	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
233413008920	Protein of unknown function DUF58; Region: DUF58; pfam01882
233413008921	MoxR-like ATPases [General function prediction only]; Region: COG0714
233413008922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413008923	Walker A motif; other site
233413008924	ATP binding site [chemical binding]; other site
233413008925	Walker B motif; other site
233413008926	arginine finger; other site
233413008927	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
233413008928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413008929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008930	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
233413008931	putative active site [active]
233413008932	putative substrate binding site [chemical binding]; other site
233413008933	ATP binding site [chemical binding]; other site
233413008934	Phosphotransferase enzyme family; Region: APH; pfam01636
233413008935	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
233413008936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413008937	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413008938	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413008939	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413008940	TAP-like protein; Region: Abhydrolase_4; pfam08386
233413008941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413008942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413008943	short chain dehydrogenase; Validated; Region: PRK08264
233413008944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413008945	NAD(P) binding site [chemical binding]; other site
233413008946	active site
233413008947	amidase; Provisional; Region: PRK06170
233413008948	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413008949	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
233413008950	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413008951	Domain of unknown function (DUF385); Region: DUF385; pfam04075
233413008952	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
233413008953	AAA domain; Region: AAA_14; pfam13173
233413008954	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
233413008955	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
233413008956	putative active site [active]
233413008957	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
233413008958	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
233413008959	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
233413008960	non-specific DNA binding site [nucleotide binding]; other site
233413008961	salt bridge; other site
233413008962	sequence-specific DNA binding site [nucleotide binding]; other site
233413008963	RES domain; Region: RES; pfam08808
233413008964	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
233413008965	Helix-turn-helix domain; Region: HTH_38; pfam13936
233413008966	Integrase core domain; Region: rve; pfam00665
233413008967	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
233413008968	hypothetical protein; Validated; Region: PRK00068
233413008969	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
233413008970	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
233413008971	Uncharacterized conserved protein [Function unknown]; Region: COG5282
233413008972	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
233413008973	ABC1 family; Region: ABC1; pfam03109
233413008974	Phosphotransferase enzyme family; Region: APH; pfam01636
233413008975	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
233413008976	active site
233413008977	ATP binding site [chemical binding]; other site
233413008978	Transcription factor WhiB; Region: Whib; pfam02467
233413008979	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
233413008980	Part of AAA domain; Region: AAA_19; pfam13245
233413008981	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
233413008982	HRDC domain; Region: HRDC; pfam00570
233413008983	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
233413008984	catalytic residues [active]
233413008985	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
233413008986	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
233413008987	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
233413008988	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
233413008989	putative NADH binding site [chemical binding]; other site
233413008990	putative active site [active]
233413008991	nudix motif; other site
233413008992	putative metal binding site [ion binding]; other site
233413008993	Ion channel; Region: Ion_trans_2; pfam07885
233413008994	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
233413008995	TrkA-N domain; Region: TrkA_N; pfam02254
233413008996	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
233413008997	Part of AAA domain; Region: AAA_19; pfam13245
233413008998	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
233413008999	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
233413009000	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
233413009001	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
233413009002	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
233413009003	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413009004	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
233413009005	catalytic site [active]
233413009006	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
233413009007	active site
233413009008	DNA binding site [nucleotide binding]
233413009009	TIGR02569 family protein; Region: TIGR02569_actnb
233413009010	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
233413009011	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
233413009012	ATP binding site [chemical binding]; other site
233413009013	substrate interface [chemical binding]; other site
233413009014	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
233413009015	active site residue [active]
233413009016	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
233413009017	Zinc-dependent metalloprotease; Region: ZnMc; smart00235
233413009018	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413009019	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413009020	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
233413009021	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
233413009022	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
233413009023	dinuclear metal binding motif [ion binding]; other site
233413009024	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
233413009025	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
233413009026	ATP binding site [chemical binding]; other site
233413009027	Mg++ binding site [ion binding]; other site
233413009028	motif III; other site
233413009029	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413009030	nucleotide binding region [chemical binding]; other site
233413009031	ATP-binding site [chemical binding]; other site
233413009032	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
233413009033	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
233413009034	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413009035	P-loop; other site
233413009036	Magnesium ion binding site [ion binding]; other site
233413009037	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413009038	catalytic core [active]
233413009039	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
233413009040	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
233413009041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413009042	Coenzyme A binding pocket [chemical binding]; other site
233413009043	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
233413009044	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
233413009045	Transcription factor WhiB; Region: Whib; pfam02467
233413009046	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
233413009047	PAS domain S-box; Region: sensory_box; TIGR00229
233413009048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
233413009049	Histidine kinase; Region: HisKA_2; pfam07568
233413009050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413009051	ATP binding site [chemical binding]; other site
233413009052	Mg2+ binding site [ion binding]; other site
233413009053	G-X-G motif; other site
233413009054	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
233413009055	carboxyltransferase (CT) interaction site; other site
233413009056	biotinylation site [posttranslational modification]; other site
233413009057	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
233413009058	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
233413009059	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413009060	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413009061	DNA binding residues [nucleotide binding]
233413009062	short chain dehydrogenase; Provisional; Region: PRK08278
233413009063	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
233413009064	NAD(P) binding site [chemical binding]; other site
233413009065	homodimer interface [polypeptide binding]; other site
233413009066	active site
233413009067	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
233413009068	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
233413009069	putative deacylase active site [active]
233413009070	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
233413009071	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413009072	Coenzyme A binding pocket [chemical binding]; other site
233413009073	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
233413009074	Phosphotransferase enzyme family; Region: APH; pfam01636
233413009075	putative active site [active]
233413009076	putative substrate binding site [chemical binding]; other site
233413009077	ATP binding site [chemical binding]; other site
233413009078	Uncharacterized conserved protein [Function unknown]; Region: COG2135
233413009079	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
233413009080	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
233413009081	hinge; other site
233413009082	active site
233413009083	Predicted GTPases [General function prediction only]; Region: COG1162
233413009084	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
233413009085	GTPase/Zn-binding domain interface [polypeptide binding]; other site
233413009086	GTP/Mg2+ binding site [chemical binding]; other site
233413009087	G4 box; other site
233413009088	G5 box; other site
233413009089	G1 box; other site
233413009090	Switch I region; other site
233413009091	G2 box; other site
233413009092	G3 box; other site
233413009093	Switch II region; other site
233413009094	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
233413009095	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
233413009096	putative di-iron ligands [ion binding]; other site
233413009097	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
233413009098	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
233413009099	FAD binding pocket [chemical binding]; other site
233413009100	FAD binding motif [chemical binding]; other site
233413009101	phosphate binding motif [ion binding]; other site
233413009102	beta-alpha-beta structure motif; other site
233413009103	NAD binding pocket [chemical binding]; other site
233413009104	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413009105	catalytic loop [active]
233413009106	iron binding site [ion binding]; other site
233413009107	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
233413009108	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413009109	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413009110	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
233413009111	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
233413009112	TrkA-C domain; Region: TrkA_C; pfam02080
233413009113	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
233413009114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413009115	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413009116	putative substrate translocation pore; other site
233413009117	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413009118	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413009119	ligand binding site [chemical binding]; other site
233413009120	flexible hinge region; other site
233413009121	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
233413009122	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
233413009123	active site
233413009124	nucleophile elbow; other site
233413009125	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
233413009126	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413009127	ATP binding site [chemical binding]; other site
233413009128	putative Mg++ binding site [ion binding]; other site
233413009129	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
233413009130	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
233413009131	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
233413009132	30S subunit binding site; other site
233413009133	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
233413009134	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413009135	active site
233413009136	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
233413009137	lipoprotein LpqB; Provisional; Region: PRK13616
233413009138	Sporulation and spore germination; Region: Germane; pfam10646
233413009139	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413009140	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413009141	dimerization interface [polypeptide binding]; other site
233413009142	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413009143	dimer interface [polypeptide binding]; other site
233413009144	phosphorylation site [posttranslational modification]
233413009145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413009146	ATP binding site [chemical binding]; other site
233413009147	Mg2+ binding site [ion binding]; other site
233413009148	G-X-G motif; other site
233413009149	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413009150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413009151	active site
233413009152	phosphorylation site [posttranslational modification]
233413009153	intermolecular recognition site; other site
233413009154	dimerization interface [polypeptide binding]; other site
233413009155	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413009156	DNA binding site [nucleotide binding]
233413009157	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
233413009158	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
233413009159	TMP-binding site; other site
233413009160	ATP-binding site [chemical binding]; other site
233413009161	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
233413009162	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
233413009163	homotetramer interface [polypeptide binding]; other site
233413009164	ligand binding site [chemical binding]; other site
233413009165	catalytic site [active]
233413009166	NAD binding site [chemical binding]; other site
233413009167	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413009168	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413009169	Rubredoxin [Energy production and conversion]; Region: COG1773
233413009170	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
233413009171	iron binding site [ion binding]; other site
233413009172	Rubredoxin [Energy production and conversion]; Region: COG1773
233413009173	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
233413009174	iron binding site [ion binding]; other site
233413009175	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
233413009176	Di-iron ligands [ion binding]; other site
233413009177	amino acid transporter; Region: 2A0306; TIGR00909
233413009178	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
233413009179	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
233413009180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413009181	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
233413009182	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
233413009183	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057
233413009184	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
233413009185	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
233413009186	active site
233413009187	substrate binding site [chemical binding]; other site
233413009188	metal binding site [ion binding]; metal-binding site
233413009189	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
233413009190	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
233413009191	Transcription factor WhiB; Region: Whib; pfam02467
233413009192	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
233413009193	phosphate binding site [ion binding]; other site
233413009194	dimer interface [polypeptide binding]; other site
233413009195	substrate binding site [chemical binding]; other site
233413009196	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
233413009197	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
233413009198	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
233413009199	putative FMN binding site [chemical binding]; other site
233413009200	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
233413009201	Methyltransferase domain; Region: Methyltransf_26; pfam13659
233413009202	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
233413009203	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
233413009204	active site
233413009205	Substrate binding site; other site
233413009206	Mg++ binding site; other site
233413009207	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
233413009208	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
233413009209	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
233413009210	Probable Catalytic site; other site
233413009211	metal-binding site
233413009212	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
233413009213	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
233413009214	NADP binding site [chemical binding]; other site
233413009215	active site
233413009216	putative substrate binding site [chemical binding]; other site
233413009217	Transcriptional regulator [Transcription]; Region: LytR; COG1316
233413009218	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
233413009219	TIGR03089 family protein; Region: TIGR03089
233413009220	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
233413009221	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
233413009222	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413009223	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413009224	active site
233413009225	motif I; other site
233413009226	motif II; other site
233413009227	Cation efflux family; Region: Cation_efflux; cl00316
233413009228	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
233413009229	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
233413009230	Sulfate transporter family; Region: Sulfate_transp; pfam00916
233413009231	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
233413009232	active site clefts [active]
233413009233	zinc binding site [ion binding]; other site
233413009234	dimer interface [polypeptide binding]; other site
233413009235	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413009236	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
233413009237	FAD binding site [chemical binding]; other site
233413009238	homotetramer interface [polypeptide binding]; other site
233413009239	substrate binding pocket [chemical binding]; other site
233413009240	catalytic base [active]
233413009241	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
233413009242	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
233413009243	ATP-grasp domain; Region: ATP-grasp; pfam02222
233413009244	Predicted membrane protein [Function unknown]; Region: COG2246
233413009245	Bacterial PH domain; Region: bPH_2; pfam03703
233413009246	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
233413009247	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
233413009248	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
233413009249	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
233413009250	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
233413009251	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413009252	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
233413009253	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
233413009254	active site
233413009255	dimer interface [polypeptide binding]; other site
233413009256	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
233413009257	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
233413009258	active site residue [active]
233413009259	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
233413009260	active site residue [active]
233413009261	Fe-S metabolizm associated domain; Region: SufE; pfam02657
233413009262	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
233413009263	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
233413009264	ATP-grasp domain; Region: ATP-grasp_4; cl17255
233413009265	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
233413009266	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
233413009267	carboxyltransferase (CT) interaction site; other site
233413009268	biotinylation site [posttranslational modification]; other site
233413009269	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
233413009270	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413009271	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
233413009272	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413009273	DNA binding residues [nucleotide binding]
233413009274	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
233413009275	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
233413009276	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
233413009277	inhibitor-cofactor binding pocket; inhibition site
233413009278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413009279	catalytic residue [active]
233413009280	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
233413009281	putative DNA binding site [nucleotide binding]; other site
233413009282	dimerization interface [polypeptide binding]; other site
233413009283	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
233413009284	putative Zn2+ binding site [ion binding]; other site
233413009285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
233413009286	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
233413009287	tetrameric interface [polypeptide binding]; other site
233413009288	NAD binding site [chemical binding]; other site
233413009289	catalytic residues [active]
233413009290	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
233413009291	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
233413009292	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413009293	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413009294	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413009295	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
233413009296	ATP binding site [chemical binding]; other site
233413009297	putative Mg++ binding site [ion binding]; other site
233413009298	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413009299	nucleotide binding region [chemical binding]; other site
233413009300	ATP-binding site [chemical binding]; other site
233413009301	DEAD/H associated; Region: DEAD_assoc; pfam08494
233413009302	Winged helix DNA-binding domain; Region: HTH_42; cl19833
233413009303	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
233413009304	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
233413009305	putative DNA binding site [nucleotide binding]; other site
233413009306	catalytic residue [active]
233413009307	putative H2TH interface [polypeptide binding]; other site
233413009308	putative catalytic residues [active]
233413009309	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
233413009310	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
233413009311	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
233413009312	Sulfatase; Region: Sulfatase; pfam00884
233413009313	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
233413009314	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
233413009315	probable active site [active]
233413009316	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
233413009317	PhoU domain; Region: PhoU; pfam01895
233413009318	PhoU domain; Region: PhoU; pfam01895
233413009319	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
233413009320	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413009321	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
233413009322	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413009323	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413009324	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
233413009325	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
233413009326	putative active site pocket [active]
233413009327	dimerization interface [polypeptide binding]; other site
233413009328	putative catalytic residue [active]
233413009329	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
233413009330	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
233413009331	metal binding site [ion binding]; metal-binding site
233413009332	putative dimer interface [polypeptide binding]; other site
233413009333	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
233413009334	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
233413009335	metal binding site [ion binding]; metal-binding site
233413009336	purine nucleoside phosphorylase; Provisional; Region: PRK08202
233413009337	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
233413009338	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
233413009339	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
233413009340	active site
233413009341	substrate binding site [chemical binding]; other site
233413009342	metal binding site [ion binding]; metal-binding site
233413009343	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413009344	active site
233413009345	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167
233413009346	Phosphoesterase family; Region: Phosphoesterase; pfam04185
233413009347	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413009348	adenosine deaminase; Provisional; Region: PRK09358
233413009349	active site
233413009350	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
233413009351	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
233413009352	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
233413009353	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
233413009354	Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295
233413009355	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
233413009356	active site
233413009357	catalytic motif [active]
233413009358	Zn binding site [ion binding]; other site
233413009359	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
233413009360	putative Iron-sulfur protein interface [polypeptide binding]; other site
233413009361	putative proximal heme binding site [chemical binding]; other site
233413009362	putative SdhD-like interface [polypeptide binding]; other site
233413009363	putative distal heme binding site [chemical binding]; other site
233413009364	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
233413009365	putative Iron-sulfur protein interface [polypeptide binding]; other site
233413009366	putative proximal heme binding site [chemical binding]; other site
233413009367	putative SdhC-like subunit interface [polypeptide binding]; other site
233413009368	putative distal heme binding site [chemical binding]; other site
233413009369	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
233413009370	L-aspartate oxidase; Provisional; Region: PRK06175
233413009371	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
233413009372	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
233413009373	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
233413009374	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
233413009375	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
233413009376	putative active site [active]
233413009377	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
233413009378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413009379	S-adenosylmethionine binding site [chemical binding]; other site
233413009380	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
233413009381	MoaE interaction surface [polypeptide binding]; other site
233413009382	MoeB interaction surface [polypeptide binding]; other site
233413009383	thiocarboxylated glycine; other site
233413009384	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
233413009385	MoaE homodimer interface [polypeptide binding]; other site
233413009386	MoaD interaction [polypeptide binding]; other site
233413009387	active site residues [active]
233413009388	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
233413009389	trimer interface [polypeptide binding]; other site
233413009390	dimer interface [polypeptide binding]; other site
233413009391	putative active site [active]
233413009392	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
233413009393	aromatic arch; other site
233413009394	DCoH dimer interaction site [polypeptide binding]; other site
233413009395	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
233413009396	DCoH tetramer interaction site [polypeptide binding]; other site
233413009397	substrate binding site [chemical binding]; other site
233413009398	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
233413009399	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413009400	FeS/SAM binding site; other site
233413009401	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
233413009402	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
233413009403	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
233413009404	DNA binding site [nucleotide binding]
233413009405	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413009406	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413009407	phosphopeptide binding site; other site
233413009408	Condensation domain; Region: Condensation; cl19241
233413009409	Transposase; Region: DEDD_Tnp_IS110; pfam01548
233413009410	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
233413009411	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
233413009412	Uncharacterized conserved protein [Function unknown]; Region: COG2128
233413009413	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
233413009414	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
233413009415	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413009416	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
233413009417	DNA binding residues [nucleotide binding]
233413009418	SnoaL-like domain; Region: SnoaL_2; pfam12680
233413009419	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
233413009420	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
233413009421	inhibitor-cofactor binding pocket; inhibition site
233413009422	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413009423	catalytic residue [active]
233413009424	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
233413009425	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
233413009426	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
233413009427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413009428	putative substrate translocation pore; other site
233413009429	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
233413009430	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
233413009431	active site
233413009432	dimer interface [polypeptide binding]; other site
233413009433	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413009434	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
233413009435	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
233413009436	DNA binding residues [nucleotide binding]
233413009437	dimer interface [polypeptide binding]; other site
233413009438	metal binding site [ion binding]; metal-binding site
233413009439	inner membrane protein YhjD; Region: TIGR00766
233413009440	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
233413009441	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
233413009442	active site
233413009443	HIGH motif; other site
233413009444	dimer interface [polypeptide binding]; other site
233413009445	KMSKS motif; other site
233413009446	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413009447	isocitrate dehydrogenase; Validated; Region: PRK08299
233413009448	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
233413009449	homodimer interface [polypeptide binding]; other site
233413009450	substrate-cofactor binding pocket; other site
233413009451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413009452	catalytic residue [active]
233413009453	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
233413009454	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
233413009455	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413009456	S-adenosylmethionine binding site [chemical binding]; other site
233413009457	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009458	PPE family; Region: PPE; pfam00823
233413009459	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009460	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009461	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009462	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009463	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009464	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009465	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009466	Mb3376c, PE_PGRS50b, len: 1337 aa. Equivalent to middle part of Rv3345c (PE_PGRS50) and Rv3344c (PE_PGRS49), len: 1538 aa and 484 aa, from Mycobacterium tuberculosis strain H37Rv, (81.45% identity in 992 aa overlap and 100.000% identity in 477 aa overlap). Rv3345c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to AAK47791 from strain CDC1551 but with some big gaps (after residues 501 and 1419; and for AAK47791 after residue 991). Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551 e.g. O53559|Rv3514|MTV023.21 (1489 aa), FASTA scores: opt: 4508, E(): 7e-161, (52.1% identity in 1529 aa overlap); MTV004_1, MTV023_21, MTV023_15, MTCY493_4, MTV039_16, MTV008_46, MTV023_14, MTV023_19, MTV043_26, MTCY493_2, MTCY441_4; etc. Rv3344c: Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins. Appears to be a gene fragment, should be in-frame with following ORF, MTV016.45c, frameshift required around 49595 but could not be found on checking BAC and cosmid clones. Similar to many from M. tuberculosis strains H37Rv and CDC1551 e.g. O53557|Rv3512|MTV023.19 (1079 aa), FASTA scores: opt: 1595, E(): 1.8e-54, (52.0% identity in 544 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b. Also in Mycobacterium tuberculosis strain H37Rv, PE_PGRS49 and PE_PGRS50 exist as 2 genes. In Mycobacterium bovis, a single base deletion (c-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product.;PE-PGRS FAMILY PROTEIN [SECOND PART]
233413009467	PE family; Region: PE; pfam00934
233413009468	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
233413009469	Mb3379c, PPE55b, len: 1061 aa. Equivalent to 3' end of Rv3347c, len: 3157 aa, from Mycobacterium tuberculosis strain H37Rv, (99.812% identity in 1061 aa overlap). Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-, Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC1551, e.g. O50379|Rv3350c|MTV004.07c (3716 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); and other upstream ORFs MTV004_5, MTY13E10_15, MTCY28_16, MTCY63_9, MTY13E10_17, MTCY180_1; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b.;PPE FAMILY PROTEIN [SECOND PART]
233413009470	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009471	PPE family; Region: PPE; pfam00823
233413009472	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009473	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009474	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009475	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009476	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009477	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009478	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009479	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009480	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009481	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009482	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009483	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009484	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009485	Transposase; Region: DEDD_Tnp_IS110; pfam01548
233413009486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
233413009487	Transposase; Region: DDE_Tnp_ISL3; pfam01610
233413009488	Mb3383c, PPE56d, len: 1219 aa. Equivalent to 3' end of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (100.000% identity in 1219 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d.;PPE FAMILY PROTEIN [THIRD PART]
233413009489	Mb3384c, PPE56b, len: 2044 aa. Equivalent to middle part of Rv3350c, len: 3716 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 2018 aa overlap). Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-, Asn-rich proteins, similar to many M. tuberculosis proteins from strains H37Rv and CDC1551, e.g. O50378|Rv3347c|MTV004.03c (3157 aa), FASTA scores: opt: 6497, E(): 0, (61.65% identity in 3756 aa overlap); MTCY28_16, MTV050_2, MTY13E10_17, MTCY63_10, MTCY180_1, MTCY63_9, MTV050_1, MTV014_3, MTY13E10_15; etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d.;PPE FAMILY PROTEIN [SECOND PART]
233413009490	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009491	PPE family; Region: PPE; pfam00823
233413009492	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009493	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009494	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009495	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009496	Berberine and berberine like; Region: BBE; pfam08031
233413009497	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413009498	Protein of unknown function (DUF732); Region: DUF732; pfam05305
233413009499	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
233413009500	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
233413009501	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
233413009502	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
233413009503	homodimer interface [polypeptide binding]; other site
233413009504	NADP binding site [chemical binding]; other site
233413009505	substrate binding site [chemical binding]; other site
233413009506	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
233413009507	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
233413009508	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
233413009509	active site
233413009510	FMN binding site [chemical binding]; other site
233413009511	substrate binding site [chemical binding]; other site
233413009512	putative catalytic residue [active]
233413009513	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413009514	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
233413009515	phosphopeptide binding site; other site
233413009516	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
233413009517	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
233413009518	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
233413009519	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
233413009520	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
233413009521	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
233413009522	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
233413009523	G1 box; other site
233413009524	GTP/Mg2+ binding site [chemical binding]; other site
233413009525	G2 box; other site
233413009526	Switch I region; other site
233413009527	G3 box; other site
233413009528	Switch II region; other site
233413009529	G4 box; other site
233413009530	G5 box; other site
233413009531	Protein of unknown function (DUF742); Region: DUF742; pfam05331
233413009532	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
233413009533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413009534	HAMP domain; Region: HAMP; pfam00672
233413009535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413009536	ATP binding site [chemical binding]; other site
233413009537	Mg2+ binding site [ion binding]; other site
233413009538	G-X-G motif; other site
233413009539	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
233413009540	PE family; Region: PE; pfam00934
233413009541	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
233413009542	FMN binding site [chemical binding]; other site
233413009543	dimer interface [polypeptide binding]; other site
233413009544	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
233413009545	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
233413009546	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
233413009547	active site
233413009548	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
233413009549	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
233413009550	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
233413009551	generic binding surface II; other site
233413009552	generic binding surface I; other site
233413009553	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413009554	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413009555	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
233413009556	trehalose-phosphatase; Region: T6PP; TIGR00685
233413009557	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
233413009558	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413009559	active site
233413009560	motif I; other site
233413009561	motif II; other site
233413009562	enoyl-CoA hydratase; Provisional; Region: PRK06144
233413009563	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413009564	substrate binding site [chemical binding]; other site
233413009565	oxyanion hole (OAH) forming residues; other site
233413009566	trimer interface [polypeptide binding]; other site
233413009567	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
233413009568	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
233413009569	HAD-hyrolase-like; Region: Hydrolase_like; cl19142
233413009570	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413009571	motif II; other site
233413009572	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
233413009573	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
233413009574	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571
233413009575	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
233413009576	TPP-binding site; other site
233413009577	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
233413009578	PYR/PP interface [polypeptide binding]; other site
233413009579	dimer interface [polypeptide binding]; other site
233413009580	TPP binding site [chemical binding]; other site
233413009581	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
233413009582	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
233413009583	Fe-S cluster binding site [ion binding]; other site
233413009584	substrate binding site [chemical binding]; other site
233413009585	catalytic site [active]
233413009586	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
233413009587	substrate binding pocket [chemical binding]; other site
233413009588	chain length determination region; other site
233413009589	substrate-Mg2+ binding site; other site
233413009590	catalytic residues [active]
233413009591	aspartate-rich region 1; other site
233413009592	active site lid residues [active]
233413009593	aspartate-rich region 2; other site
233413009594	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
233413009595	putative active site [active]
233413009596	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
233413009597	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
233413009598	Transposase domain (DUF772); Region: DUF772; pfam05598
233413009599	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
233413009600	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
233413009601	PE family; Region: PE; pfam00934
233413009602	enoyl-CoA hydratase; Region: PLN02864
233413009603	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
233413009604	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
233413009605	dimer interaction site [polypeptide binding]; other site
233413009606	substrate-binding tunnel; other site
233413009607	active site
233413009608	catalytic site [active]
233413009609	substrate binding site [chemical binding]; other site
233413009610	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413009611	short chain dehydrogenase; Provisional; Region: PRK07201
233413009612	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
233413009613	putative NAD(P) binding site [chemical binding]; other site
233413009614	active site
233413009615	putative substrate binding site [chemical binding]; other site
233413009616	classical (c) SDRs; Region: SDR_c; cd05233
233413009617	NAD(P) binding site [chemical binding]; other site
233413009618	active site
233413009619	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413009620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
233413009621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413009622	S-adenosylmethionine binding site [chemical binding]; other site
233413009623	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
233413009624	active site
233413009625	DNA Polymerase Y-family; Region: PolY_like; cd03468
233413009626	active site
233413009627	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
233413009628	DNA binding site [nucleotide binding]
233413009629	GMP synthase; Reviewed; Region: guaA; PRK00074
233413009630	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
233413009631	AMP/PPi binding site [chemical binding]; other site
233413009632	candidate oxyanion hole; other site
233413009633	catalytic triad [active]
233413009634	potential glutamine specificity residues [chemical binding]; other site
233413009635	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
233413009636	ATP Binding subdomain [chemical binding]; other site
233413009637	Ligand Binding sites [chemical binding]; other site
233413009638	Dimerization subdomain; other site
233413009639	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
233413009640	active site lid residues [active]
233413009641	substrate binding pocket [chemical binding]; other site
233413009642	catalytic residues [active]
233413009643	substrate-Mg2+ binding site; other site
233413009644	aspartate-rich region 1; other site
233413009645	aspartate-rich region 2; other site
233413009646	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
233413009647	substrate binding pocket [chemical binding]; other site
233413009648	chain length determination region; other site
233413009649	substrate-Mg2+ binding site; other site
233413009650	catalytic residues [active]
233413009651	aspartate-rich region 1; other site
233413009652	active site lid residues [active]
233413009653	aspartate-rich region 2; other site
233413009654	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413009655	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
233413009656	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
233413009657	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413009658	motif II; other site
233413009659	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
233413009660	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
233413009661	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
233413009662	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
233413009663	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
233413009664	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413009665	catalytic residue [active]
233413009666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
233413009667	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413009668	hypothetical protein; Provisional; Region: PRK07579
233413009669	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
233413009670	active site
233413009671	cosubstrate binding site; other site
233413009672	substrate binding site [chemical binding]; other site
233413009673	catalytic site [active]
233413009674	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413009675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413009676	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
233413009677	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
233413009678	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
233413009679	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
233413009680	putative active site [active]
233413009681	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
233413009682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413009683	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413009684	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
233413009685	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
233413009686	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
233413009687	phosphate binding site [ion binding]; other site
233413009688	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
233413009689	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
233413009690	active site
233413009691	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
233413009692	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
233413009693	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413009694	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
233413009695	DNA binding residues [nucleotide binding]
233413009696	tetratricopeptide repeat protein; Provisional; Region: PRK11788
233413009697	Transcription factor WhiB; Region: Whib; pfam02467
233413009698	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
233413009699	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
233413009700	ring oligomerisation interface [polypeptide binding]; other site
233413009701	ATP/Mg binding site [chemical binding]; other site
233413009702	stacking interactions; other site
233413009703	hinge regions; other site
233413009704	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
233413009705	oligomerisation interface [polypeptide binding]; other site
233413009706	mobile loop; other site
233413009707	roof hairpin; other site
233413009708	UGMP family protein; Validated; Region: PRK09604
233413009709	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
233413009710	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
233413009711	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
233413009712	Coenzyme A binding pocket [chemical binding]; other site
233413009713	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
233413009714	Glycoprotease family; Region: Peptidase_M22; pfam00814
233413009715	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
233413009716	alanine racemase; Reviewed; Region: alr; PRK00053
233413009717	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
233413009718	active site
233413009719	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
233413009720	dimer interface [polypeptide binding]; other site
233413009721	substrate binding site [chemical binding]; other site
233413009722	catalytic residues [active]
233413009723	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009724	PPE family; Region: PPE; pfam00823
233413009725	putative transposase OrfB; Reviewed; Region: PHA02517
233413009726	Integrase core domain; Region: rve; pfam00665
233413009727	Integrase core domain; Region: rve_3; pfam13683
233413009728	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413009729	Transposase, Mutator family; Region: Transposase_mut; cl19537
233413009730	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
233413009731	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413009732	catalytic residue [active]
233413009733	Uncharacterized conserved protein [Function unknown]; Region: COG0062
233413009734	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
233413009735	putative substrate binding site [chemical binding]; other site
233413009736	putative ATP binding site [chemical binding]; other site
233413009737	Domain of unknown function (DUF4436); Region: DUF4436; pfam14494
233413009738	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
233413009739	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
233413009740	glutaminase active site [active]
233413009741	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
233413009742	dimer interface [polypeptide binding]; other site
233413009743	active site
233413009744	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
233413009745	dimer interface [polypeptide binding]; other site
233413009746	active site
233413009747	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
233413009748	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413009749	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
233413009750	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
233413009751	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
233413009752	active site
233413009753	substrate binding site [chemical binding]; other site
233413009754	metal binding site [ion binding]; metal-binding site
233413009755	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
233413009756	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
233413009757	23S rRNA interface [nucleotide binding]; other site
233413009758	L3 interface [polypeptide binding]; other site
233413009759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
233413009760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
233413009761	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
233413009762	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
233413009763	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413009764	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
233413009765	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413009766	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413009767	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
233413009768	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
233413009769	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
233413009770	active site
233413009771	catalytic residues [active]
233413009772	Protein of unknown function (DUF690); Region: DUF690; pfam05108
233413009773	Cutinase; Region: Cutinase; pfam01083
233413009774	Cutinase; Region: Cutinase; pfam01083
233413009775	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
233413009776	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
233413009777	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
233413009778	dimerization interface 3.5A [polypeptide binding]; other site
233413009779	active site
233413009780	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
233413009781	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
233413009782	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
233413009783	alphaNTD - beta interaction site [polypeptide binding]; other site
233413009784	alphaNTD homodimer interface [polypeptide binding]; other site
233413009785	alphaNTD - beta' interaction site [polypeptide binding]; other site
233413009786	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
233413009787	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
233413009788	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
233413009789	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
233413009790	RNA binding surface [nucleotide binding]; other site
233413009791	30S ribosomal protein S11; Validated; Region: PRK05309
233413009792	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
233413009793	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
233413009794	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
233413009795	rRNA binding site [nucleotide binding]; other site
233413009796	predicted 30S ribosome binding site; other site
233413009797	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
233413009798	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
233413009799	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
233413009800	NAD binding site [chemical binding]; other site
233413009801	substrate binding site [chemical binding]; other site
233413009802	homodimer interface [polypeptide binding]; other site
233413009803	active site
233413009804	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
233413009805	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413009806	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413009807	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413009808	active site
233413009809	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413009810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413009811	NAD(P) binding site [chemical binding]; other site
233413009812	active site
233413009813	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
233413009814	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
233413009815	active site
233413009816	catalytic residues [active]
233413009817	metal binding site [ion binding]; metal-binding site
233413009818	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
233413009819	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
233413009820	PYR/PP interface [polypeptide binding]; other site
233413009821	dimer interface [polypeptide binding]; other site
233413009822	TPP binding site [chemical binding]; other site
233413009823	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
233413009824	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
233413009825	TPP-binding site [chemical binding]; other site
233413009826	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
233413009827	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
233413009828	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413009829	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
233413009830	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413009831	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413009832	metabolite-proton symporter; Region: 2A0106; TIGR00883
233413009833	putative substrate translocation pore; other site
233413009834	PE family; Region: PE; pfam00934
233413009835	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009836	PPE family; Region: PPE; pfam00823
233413009837	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413009838	Patatin-like phospholipase; Region: Patatin; pfam01734
233413009839	nucleophile elbow; other site
233413009840	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
233413009841	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
233413009842	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413009843	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413009844	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
233413009845	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413009846	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
233413009847	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
233413009848	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
233413009849	Transcriptional regulator [Transcription]; Region: LytR; COG1316
233413009850	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
233413009851	short chain dehydrogenase; Provisional; Region: PRK07774
233413009852	classical (c) SDRs; Region: SDR_c; cd05233
233413009853	NAD(P) binding site [chemical binding]; other site
233413009854	active site
233413009855	Predicted membrane protein [Function unknown]; Region: COG2259
233413009856	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
233413009857	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
233413009858	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
233413009859	Transcriptional regulators [Transcription]; Region: MarR; COG1846
233413009860	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
233413009861	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
233413009862	active site
233413009863	homotetramer interface [polypeptide binding]; other site
233413009864	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413009865	mce related protein; Region: MCE; pfam02470
233413009866	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413009867	mce related protein; Region: MCE; pfam02470
233413009868	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413009869	mce related protein; Region: MCE; pfam02470
233413009870	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413009871	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413009872	mce related protein; Region: MCE; pfam02470
233413009873	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413009874	mce related protein; Region: MCE; pfam02470
233413009875	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413009876	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
233413009877	mce related protein; Region: MCE; pfam02470
233413009878	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
233413009879	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
233413009880	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
233413009881	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
233413009882	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413009883	NAD(P) binding site [chemical binding]; other site
233413009884	active site
233413009885	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
233413009886	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413009887	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
233413009888	FAD binding site [chemical binding]; other site
233413009889	substrate binding site [chemical binding]; other site
233413009890	catalytic base [active]
233413009891	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413009892	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
233413009893	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
233413009894	active site
233413009895	acyl-CoA synthetase; Validated; Region: PRK07867
233413009896	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
233413009897	acyl-activating enzyme (AAE) consensus motif; other site
233413009898	putative AMP binding site [chemical binding]; other site
233413009899	putative active site [active]
233413009900	putative CoA binding site [chemical binding]; other site
233413009901	PE family; Region: PE; pfam00934
233413009902	PE family; Region: PE; pfam00934
233413009903	hypothetical protein; Validated; Region: PRK07586
233413009904	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
233413009905	PYR/PP interface [polypeptide binding]; other site
233413009906	dimer interface [polypeptide binding]; other site
233413009907	TPP binding site [chemical binding]; other site
233413009908	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
233413009909	TPP-binding site [chemical binding]; other site
233413009910	dimer interface [polypeptide binding]; other site
233413009911	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
233413009912	PE family; Region: PE; pfam00934
233413009913	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413009914	CoA binding site [chemical binding]; other site
233413009915	PE family; Region: PE; pfam00934
233413009916	acyl-CoA synthetase; Validated; Region: PRK07798
233413009917	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413009918	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
233413009919	acyl-activating enzyme (AAE) consensus motif; other site
233413009920	acyl-activating enzyme (AAE) consensus motif; other site
233413009921	putative AMP binding site [chemical binding]; other site
233413009922	putative active site [active]
233413009923	putative CoA binding site [chemical binding]; other site
233413009924	enoyl-CoA hydratase; Provisional; Region: PRK07799
233413009925	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413009926	substrate binding site [chemical binding]; other site
233413009927	oxyanion hole (OAH) forming residues; other site
233413009928	trimer interface [polypeptide binding]; other site
233413009929	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
233413009930	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413009931	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413009932	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
233413009933	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
233413009934	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
233413009935	DUF35 OB-fold domain; Region: DUF35; pfam01796
233413009936	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
233413009937	DUF35 OB-fold domain; Region: DUF35; pfam01796
233413009938	lipid-transfer protein; Provisional; Region: PRK07937
233413009939	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
233413009940	active site
233413009941	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
233413009942	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
233413009943	active site
233413009944	Uncharacterized conserved protein [Function unknown]; Region: COG3391
233413009945	NHL repeat; Region: NHL; pfam01436
233413009946	NHL repeat; Region: NHL; pfam01436
233413009947	NHL repeat; Region: NHL; pfam01436
233413009948	NHL repeat; Region: NHL; pfam01436
233413009949	NHL repeat; Region: NHL; pfam01436
233413009950	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
233413009951	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
233413009952	trimer interface [polypeptide binding]; other site
233413009953	putative metal binding site [ion binding]; other site
233413009954	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
233413009955	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
233413009956	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
233413009957	short chain dehydrogenase; Provisional; Region: PRK07890
233413009958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413009959	NAD(P) binding site [chemical binding]; other site
233413009960	active site
233413009961	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009962	PPE family; Region: PPE; pfam00823
233413009963	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
233413009964	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009965	PPE family; Region: PPE; pfam00823
233413009966	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009967	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009968	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009969	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009970	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009971	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009972	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413009973	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
233413009974	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
233413009975	active site
233413009976	catalytic residues [active]
233413009977	metal binding site [ion binding]; metal-binding site
233413009978	DmpG-like communication domain; Region: DmpG_comm; pfam07836
233413009979	acetaldehyde dehydrogenase; Validated; Region: PRK08300
233413009980	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
233413009981	Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290
233413009982	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
233413009983	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
233413009984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413009985	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413009986	enoyl-CoA hydratase; Region: PLN02864
233413009987	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
233413009988	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
233413009989	dimer interaction site [polypeptide binding]; other site
233413009990	substrate-binding tunnel; other site
233413009991	active site
233413009992	catalytic site [active]
233413009993	substrate binding site [chemical binding]; other site
233413009994	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413009995	PPE family; Region: PPE; pfam00823
233413009996	PE-PPE domain; Region: PE-PPE; pfam08237
233413009997	lipid-transfer protein; Provisional; Region: PRK07855
233413009998	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
233413009999	active site
233413010000	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
233413010001	putative active site [active]
233413010002	putative catalytic site [active]
233413010003	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
233413010004	active site
233413010005	catalytic site [active]
233413010006	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
233413010007	DUF35 OB-fold domain; Region: DUF35; pfam01796
233413010008	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010009	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010010	active site
233413010011	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010012	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
233413010013	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010014	active site
233413010015	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413010016	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
233413010017	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
233413010018	dimer interface [polypeptide binding]; other site
233413010019	active site
233413010020	Domain of unknown function (DUF385); Region: DUF385; pfam04075
233413010021	short chain dehydrogenase; Provisional; Region: PRK07791
233413010022	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
233413010023	homodimer interface [polypeptide binding]; other site
233413010024	NAD binding site [chemical binding]; other site
233413010025	active site
233413010026	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
233413010027	classical (c) SDRs; Region: SDR_c; cd05233
233413010028	NAD(P) binding site [chemical binding]; other site
233413010029	active site
233413010030	enoyl-CoA hydratase; Provisional; Region: PRK07938
233413010031	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413010032	substrate binding site [chemical binding]; other site
233413010033	oxyanion hole (OAH) forming residues; other site
233413010034	trimer interface [polypeptide binding]; other site
233413010035	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
233413010036	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
233413010037	Nitronate monooxygenase; Region: NMO; pfam03060
233413010038	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
233413010039	FMN binding site [chemical binding]; other site
233413010040	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
233413010041	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
233413010042	putative di-iron ligands [ion binding]; other site
233413010043	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
233413010044	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
233413010045	FAD binding pocket [chemical binding]; other site
233413010046	FAD binding motif [chemical binding]; other site
233413010047	phosphate binding motif [ion binding]; other site
233413010048	beta-alpha-beta structure motif; other site
233413010049	NAD(p) ribose binding residues [chemical binding]; other site
233413010050	NAD binding pocket [chemical binding]; other site
233413010051	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
233413010052	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413010053	catalytic loop [active]
233413010054	iron binding site [ion binding]; other site
233413010055	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
233413010056	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
233413010057	putative active site [active]
233413010058	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
233413010059	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
233413010060	dimer interface [polypeptide binding]; other site
233413010061	active site
233413010062	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413010063	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413010064	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413010065	PPE family; Region: PPE; pfam00823
233413010066	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413010067	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413010068	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
233413010069	short chain dehydrogenase; Provisional; Region: PRK07831
233413010070	classical (c) SDRs; Region: SDR_c; cd05233
233413010071	NAD(P) binding site [chemical binding]; other site
233413010072	active site
233413010073	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
233413010074	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010075	active site
233413010076	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
233413010077	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
233413010078	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
233413010079	acyl-activating enzyme (AAE) consensus motif; other site
233413010080	acyl-activating enzyme (AAE) consensus motif; other site
233413010081	putative AMP binding site [chemical binding]; other site
233413010082	putative active site [active]
233413010083	putative CoA binding site [chemical binding]; other site
233413010084	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010085	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010086	active site
233413010087	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010088	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932
233413010089	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010090	active site
233413010091	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010092	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010093	active site
233413010094	aspartate aminotransferase; Provisional; Region: PRK05764
233413010095	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413010096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413010097	homodimer interface [polypeptide binding]; other site
233413010098	catalytic residue [active]
233413010099	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
233413010100	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
233413010101	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
233413010102	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
233413010103	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
233413010104	active site
233413010105	Fe binding site [ion binding]; other site
233413010106	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
233413010107	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413010108	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010109	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
233413010110	Flavin binding site [chemical binding]; other site
233413010111	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
233413010112	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
233413010113	FAD binding pocket [chemical binding]; other site
233413010114	FAD binding motif [chemical binding]; other site
233413010115	phosphate binding motif [ion binding]; other site
233413010116	beta-alpha-beta structure motif; other site
233413010117	NAD(p) ribose binding residues [chemical binding]; other site
233413010118	NAD binding pocket [chemical binding]; other site
233413010119	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
233413010120	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
233413010121	catalytic loop [active]
233413010122	iron binding site [ion binding]; other site
233413010123	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010124	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010125	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
233413010126	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
233413010127	active site
233413010128	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413010129	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413010130	Transcriptional regulators [Transcription]; Region: PurR; COG1609
233413010131	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
233413010132	DNA binding site [nucleotide binding]
233413010133	domain linker motif; other site
233413010134	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
233413010135	putative dimerization interface [polypeptide binding]; other site
233413010136	putative ligand binding site [chemical binding]; other site
233413010137	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413010138	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
233413010139	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
233413010140	transmembrane helices; other site
233413010141	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
233413010142	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
233413010143	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
233413010144	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
233413010145	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
233413010146	active site
233413010147	HIGH motif; other site
233413010148	KMSKS motif; other site
233413010149	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
233413010150	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
233413010151	homotrimer interaction site [polypeptide binding]; other site
233413010152	zinc binding site [ion binding]; other site
233413010153	CDP-binding sites; other site
233413010154	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
233413010155	substrate binding site; other site
233413010156	dimer interface; other site
233413010157	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
233413010158	DNA repair protein RadA; Provisional; Region: PRK11823
233413010159	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
233413010160	Walker A motif/ATP binding site; other site
233413010161	ATP binding site [chemical binding]; other site
233413010162	Walker B motif; other site
233413010163	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
233413010164	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
233413010165	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
233413010166	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
233413010167	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
233413010168	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
233413010169	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
233413010170	active site clefts [active]
233413010171	zinc binding site [ion binding]; other site
233413010172	dimer interface [polypeptide binding]; other site
233413010173	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
233413010174	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
233413010175	minor groove reading motif; other site
233413010176	helix-hairpin-helix signature motif; other site
233413010177	substrate binding pocket [chemical binding]; other site
233413010178	active site
233413010179	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
233413010180	PE family; Region: PE; pfam00934
233413010181	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413010182	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413010183	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
233413010184	catalytic site [active]
233413010185	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
233413010186	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
233413010187	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
233413010188	Ami_2 domain; Region: Ami_2; smart00644
233413010189	amidase catalytic site [active]
233413010190	Zn binding residues [ion binding]; other site
233413010191	substrate binding site [chemical binding]; other site
233413010192	PE family; Region: PE; pfam00934
233413010193	Clp protease ATP binding subunit; Region: clpC; CHL00095
233413010194	Clp amino terminal domain; Region: Clp_N; pfam02861
233413010195	Clp amino terminal domain; Region: Clp_N; pfam02861
233413010196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010197	Walker A motif; other site
233413010198	ATP binding site [chemical binding]; other site
233413010199	Walker B motif; other site
233413010200	arginine finger; other site
233413010201	UvrB/uvrC motif; Region: UVR; pfam02151
233413010202	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010203	Walker A motif; other site
233413010204	ATP binding site [chemical binding]; other site
233413010205	Walker B motif; other site
233413010206	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
233413010207	Lsr2; Region: Lsr2; pfam11774
233413010208	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
233413010209	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
233413010210	dimer interface [polypeptide binding]; other site
233413010211	putative anticodon binding site; other site
233413010212	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
233413010213	motif 1; other site
233413010214	dimer interface [polypeptide binding]; other site
233413010215	active site
233413010216	motif 2; other site
233413010217	motif 3; other site
233413010218	pantothenate kinase; Reviewed; Region: PRK13318
233413010219	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
233413010220	tetramerization interface [polypeptide binding]; other site
233413010221	active site
233413010222	Pantoate-beta-alanine ligase; Region: PanC; cd00560
233413010223	active site
233413010224	ATP-binding site [chemical binding]; other site
233413010225	pantoate-binding site; other site
233413010226	HXXH motif; other site
233413010227	Uncharacterized conserved protein [Function unknown]; Region: COG5495
233413010228	Rossmann-like domain; Region: Rossmann-like; pfam10727
233413010229	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
233413010230	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
233413010231	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
233413010232	catalytic center binding site [active]
233413010233	ATP binding site [chemical binding]; other site
233413010234	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
233413010235	homooctamer interface [polypeptide binding]; other site
233413010236	active site
233413010237	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
233413010238	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
233413010239	substrate binding pocket [chemical binding]; other site
233413010240	dimer interface [polypeptide binding]; other site
233413010241	inhibitor binding site; inhibition site
233413010242	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
233413010243	active site
233413010244	FtsH Extracellular; Region: FtsH_ext; pfam06480
233413010245	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
233413010246	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010247	Walker A motif; other site
233413010248	ATP binding site [chemical binding]; other site
233413010249	Walker B motif; other site
233413010250	arginine finger; other site
233413010251	Peptidase family M41; Region: Peptidase_M41; pfam01434
233413010252	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
233413010253	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
233413010254	Protein of unknown function (DUF541); Region: SIMPL; cl01077
233413010255	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
233413010256	active site
233413010257	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
233413010258	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
233413010259	Ligand Binding Site [chemical binding]; other site
233413010260	TilS substrate binding domain; Region: TilS; pfam09179
233413010261	Uncharacterized conserved protein [Function unknown]; Region: COG5282
233413010262	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
233413010263	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
233413010264	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
233413010265	dimer interface [polypeptide binding]; other site
233413010266	substrate binding site [chemical binding]; other site
233413010267	metal binding sites [ion binding]; metal-binding site
233413010268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
233413010269	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
233413010270	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
233413010271	Ligand binding site; other site
233413010272	Putative Catalytic site; other site
233413010273	DXD motif; other site
233413010274	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
233413010275	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
233413010276	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413010277	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413010278	NAD(P) binding site [chemical binding]; other site
233413010279	active site
233413010280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
233413010281	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
233413010282	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
233413010283	DNA-binding interface [nucleotide binding]; DNA binding site
233413010284	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
233413010285	transposase; Provisional; Region: PRK06526
233413010286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010287	Walker B motif; other site
233413010288	Transposase, Mutator family; Region: Transposase_mut; pfam00872
233413010289	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
233413010290	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
233413010291	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
233413010292	FIC domain binding interface [polypeptide binding]; other site
233413010293	DNA polymerase III subunit delta'; Validated; Region: PRK07940
233413010294	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010295	Walker A motif; other site
233413010296	ATP binding site [chemical binding]; other site
233413010297	Walker B motif; other site
233413010298	arginine finger; other site
233413010299	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413010300	dimerization interface [polypeptide binding]; other site
233413010301	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
233413010302	cyclase homology domain; Region: CHD; cd07302
233413010303	nucleotidyl binding site; other site
233413010304	metal binding site [ion binding]; metal-binding site
233413010305	dimer interface [polypeptide binding]; other site
233413010306	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
233413010307	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
233413010308	active site
233413010309	interdomain interaction site; other site
233413010310	putative metal-binding site [ion binding]; other site
233413010311	nucleotide binding site [chemical binding]; other site
233413010312	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
233413010313	domain I; other site
233413010314	DNA binding groove [nucleotide binding]
233413010315	phosphate binding site [ion binding]; other site
233413010316	domain II; other site
233413010317	domain III; other site
233413010318	nucleotide binding site [chemical binding]; other site
233413010319	catalytic site [active]
233413010320	domain IV; other site
233413010321	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
233413010322	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
233413010323	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
233413010324	DNA-binding site [nucleotide binding]; DNA binding site
233413010325	RNA-binding motif; other site
233413010326	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
233413010327	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
233413010328	ATP binding site [chemical binding]; other site
233413010329	putative Mg++ binding site [ion binding]; other site
233413010330	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
233413010331	nucleotide binding region [chemical binding]; other site
233413010332	ATP-binding site [chemical binding]; other site
233413010333	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
233413010334	PE family; Region: PE; pfam00934
233413010335	PE family; Region: PE; pfam00934
233413010336	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
233413010337	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
233413010338	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
233413010339	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
233413010340	Walker A motif; other site
233413010341	hexamer interface [polypeptide binding]; other site
233413010342	ATP binding site [chemical binding]; other site
233413010343	Walker B motif; other site
233413010344	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
233413010345	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
233413010346	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413010347	motif II; other site
233413010348	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
233413010349	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
233413010350	Walker A/P-loop; other site
233413010351	ATP binding site [chemical binding]; other site
233413010352	Q-loop/lid; other site
233413010353	ABC transporter signature motif; other site
233413010354	Walker B; other site
233413010355	D-loop; other site
233413010356	H-loop/switch region; other site
233413010357	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
233413010358	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
233413010359	Walker A/P-loop; other site
233413010360	ATP binding site [chemical binding]; other site
233413010361	Q-loop/lid; other site
233413010362	ABC transporter signature motif; other site
233413010363	Walker B; other site
233413010364	D-loop; other site
233413010365	H-loop/switch region; other site
233413010366	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
233413010367	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
233413010368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413010369	dimer interface [polypeptide binding]; other site
233413010370	conserved gate region; other site
233413010371	putative PBP binding loops; other site
233413010372	ABC-ATPase subunit interface; other site
233413010373	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
233413010374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413010375	dimer interface [polypeptide binding]; other site
233413010376	conserved gate region; other site
233413010377	putative PBP binding loops; other site
233413010378	ABC-ATPase subunit interface; other site
233413010379	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
233413010380	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
233413010381	acetyl-CoA synthetase; Provisional; Region: PRK00174
233413010382	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
233413010383	active site
233413010384	CoA binding site [chemical binding]; other site
233413010385	acyl-activating enzyme (AAE) consensus motif; other site
233413010386	AMP binding site [chemical binding]; other site
233413010387	acetate binding site [chemical binding]; other site
233413010388	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
233413010389	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
233413010390	Putative lysophospholipase; Region: Hydrolase_4; cl19140
233413010391	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
233413010392	Colicin V production protein; Region: Colicin_V; pfam02674
233413010393	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
233413010394	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
233413010395	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
233413010396	putative active site [active]
233413010397	putative CoA binding site [chemical binding]; other site
233413010398	nudix motif; other site
233413010399	metal binding site [ion binding]; metal-binding site
233413010400	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
233413010401	catalytic residues [active]
233413010402	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
233413010403	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
233413010404	minor groove reading motif; other site
233413010405	helix-hairpin-helix signature motif; other site
233413010406	substrate binding pocket [chemical binding]; other site
233413010407	active site
233413010408	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
233413010409	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413010410	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413010411	ligand binding site [chemical binding]; other site
233413010412	flexible hinge region; other site
233413010413	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
233413010414	putative switch regulator; other site
233413010415	non-specific DNA interactions [nucleotide binding]; other site
233413010416	DNA binding site [nucleotide binding]
233413010417	sequence specific DNA binding site [nucleotide binding]; other site
233413010418	putative cAMP binding site [chemical binding]; other site
233413010419	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
233413010420	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
233413010421	homotrimer interaction site [polypeptide binding]; other site
233413010422	putative active site [active]
233413010423	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
233413010424	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
233413010425	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
233413010426	P loop; other site
233413010427	Nucleotide binding site [chemical binding]; other site
233413010428	DTAP/Switch II; other site
233413010429	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
233413010430	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
233413010431	P loop; other site
233413010432	Nucleotide binding site [chemical binding]; other site
233413010433	DTAP/Switch II; other site
233413010434	Switch I; other site
233413010435	Transcription factor WhiB; Region: Whib; pfam02467
233413010436	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
233413010437	Transglycosylase; Region: Transgly; pfam00912
233413010438	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
233413010439	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
233413010440	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
233413010441	putative active site [active]
233413010442	putative metal binding site [ion binding]; other site
233413010443	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
233413010444	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413010445	catalytic residue [active]
233413010446	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
233413010447	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366
233413010448	Uncharacterized conserved protein [Function unknown]; Region: COG1610
233413010449	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
233413010450	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
233413010451	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
233413010452	MoxR-like ATPases [General function prediction only]; Region: COG0714
233413010453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010454	Walker A motif; other site
233413010455	ATP binding site [chemical binding]; other site
233413010456	Walker B motif; other site
233413010457	arginine finger; other site
233413010458	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
233413010459	Protein of unknown function DUF58; Region: DUF58; pfam01882
233413010460	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
233413010461	Predicted membrane protein/domain [Function unknown]; Region: COG1714
233413010462	Mb3721c, glpKb, len: 326 aa. Equivalent to 3' end of Rv3696c, len: 517 aa, from Mycobacterium tuberculosis strain H37Rv, (99.4% identity in 326 aa overlap). Probable glpK, glycerol kinase (EC 2.7.1.30), equivalent to Q9CB81|GLPK_MYCLE|ML2314 GLYCEROL KINASE from Mycobacterium leprae (508 aa), FASTA scores: opt: 3120, E(): 4.7e-189, (91.35% identity in 508 aa overlap). Also highly similar to others e.g. Q9RJM2|GLPK from Streptomyces coelicolor (507 aa), FASTA scores: opt: 2606, E(): 1.1e-156, (75.35% identity in 503 aa overlap); Q9ADA7|GLPK from Streptomyces coelicolor (512 aa) FASTA scores: opt: 2002, E(): 1.3e-118, (59.05% identity in 503 aa overlap); Q9X1E4|GLK2_THEMA|TM1430 from Thermotoga maritima (496 aa), FASTA scores: opt: 1838, E(): 2.7e-108, (54.8% identity in 498 aa overlap); P08859|GLPK_ECOLI|B3926 from Escherichia coli strain K12 (501 aa), FASTA scores: opt: 1740, E(): 4.1e-102, (52.3% identity in 499 aa overlap); etc. Contains PS00933 FGGY family of carbohydrate kinases signature 1, PS00070 Aldehyde dehydrogenases cysteine active site, PS00445 FGGY family of carbohydrate kinases signature 2. BELONGS TO THE FUCOKINASE / GLUCONOKINASE / GLYCEROKINASE / XYLULOKINase. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, glpK exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-g), splits glpK into 2 parts, glpKa and glpKb and removes activity.;PROBABLE GLYCEROL KINASE GLPKB [SECOND PART] (ATP:GLYCEROL 3-PHOSPHOTRANSFERASE)(GLYCEROKINASE) (GK)
233413010463	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
233413010464	nucleotide binding site [chemical binding]; other site
233413010465	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
233413010466	putative active site [active]
233413010467	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
233413010468	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
233413010469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413010470	S-adenosylmethionine binding site [chemical binding]; other site
233413010471	ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343
233413010472	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413010473	catalytic residue [active]
233413010474	Uncharacterized conserved protein [Function unknown]; Region: COG4301
233413010475	Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017
233413010476	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
233413010477	putative active site [active]
233413010478	putative dimer interface [polypeptide binding]; other site
233413010479	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
233413010480	DinB superfamily; Region: DinB_2; pfam12867
233413010481	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781
233413010482	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
233413010483	PknH-like extracellular domain; Region: PknH_C; pfam14032
233413010484	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
233413010485	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
233413010486	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
233413010487	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
233413010488	aspartate kinase; Reviewed; Region: PRK06635
233413010489	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
233413010490	putative nucleotide binding site [chemical binding]; other site
233413010491	putative catalytic residues [active]
233413010492	putative Mg ion binding site [ion binding]; other site
233413010493	putative aspartate binding site [chemical binding]; other site
233413010494	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
233413010495	putative allosteric regulatory site; other site
233413010496	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
233413010497	2-isopropylmalate synthase; Validated; Region: PRK03739
233413010498	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
233413010499	active site
233413010500	catalytic residues [active]
233413010501	metal binding site [ion binding]; metal-binding site
233413010502	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
233413010503	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
233413010504	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
233413010505	active site
233413010506	catalytic site [active]
233413010507	substrate binding site [chemical binding]; other site
233413010508	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
233413010509	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
233413010510	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
233413010511	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
233413010512	catalytic triad [active]
233413010513	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
233413010514	putative active site [active]
233413010515	recombination protein RecR; Reviewed; Region: recR; PRK00076
233413010516	Helix-hairpin-helix motif; Region: HHH; pfam00633
233413010517	RecR protein; Region: RecR; pfam02132
233413010518	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
233413010519	putative active site [active]
233413010520	putative metal-binding site [ion binding]; other site
233413010521	tetramer interface [polypeptide binding]; other site
233413010522	hypothetical protein; Validated; Region: PRK00153
233413010523	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
233413010524	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
233413010525	active site
233413010526	metal binding site [ion binding]; metal-binding site
233413010527	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
233413010528	hydrophobic ligand binding site; other site
233413010529	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413010530	FAD binding domain; Region: FAD_binding_4; cl19922
233413010531	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
233413010532	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413010533	S-adenosylmethionine binding site [chemical binding]; other site
233413010534	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
233413010535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010536	Walker A motif; other site
233413010537	ATP binding site [chemical binding]; other site
233413010538	Walker B motif; other site
233413010539	arginine finger; other site
233413010540	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
233413010541	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
233413010542	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
233413010543	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413010544	catalytic residue [active]
233413010545	Cutinase; Region: Cutinase; pfam01083
233413010546	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
233413010547	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413010548	NAD(P) binding site [chemical binding]; other site
233413010549	active site
233413010550	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
233413010551	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
233413010552	putative NAD(P) binding site [chemical binding]; other site
233413010553	catalytic Zn binding site [ion binding]; other site
233413010554	Uncharacterized conserved protein [Function unknown]; Region: COG3349
233413010555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413010556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
233413010557	Major Facilitator Superfamily; Region: MFS_1; pfam07690
233413010558	putative substrate translocation pore; other site
233413010559	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
233413010560	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
233413010561	ligand binding site [chemical binding]; other site
233413010562	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
233413010563	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
233413010564	active site
233413010565	nucleophile elbow; other site
233413010566	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
233413010567	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
233413010568	FeS/SAM binding site; other site
233413010569	Methyltransferase domain; Region: Methyltransf_31; pfam13847
233413010570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413010571	S-adenosylmethionine binding site [chemical binding]; other site
233413010572	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
233413010573	nucleotide binding site [chemical binding]; other site
233413010574	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
233413010575	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
233413010576	active site
233413010577	DNA binding site [nucleotide binding]
233413010578	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
233413010579	DNA binding site [nucleotide binding]
233413010580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
233413010581	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662
233413010582	nudix motif; other site
233413010583	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413010584	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413010585	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
233413010586	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
233413010587	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
233413010588	Uncharacterized conserved protein [Function unknown]; Region: COG2966
233413010589	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
233413010590	Uncharacterized conserved protein [Function unknown]; Region: COG3610
233413010591	Mb3765c, PPE66, len: 118 aa. Equivalent to 3' end of Rv3738c, len: 315 aa, from Mycobacterium tuberculosis strain H37Rv, (98.1% identity in 105 aa overlap). Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa), FASTA scores: opt: 464, E(): 2.2e-17, (47.05% identity in 338 aa overlap). Probably a continuation of the upstream ORF MTV025.87c. At position 97470-72 a stop codon is present which interrupts a possibly longer ORF, observed in related ORFs MTV012_32 or MTCY21B4_4. The sequence has been checked and no errors were detected. A similar situation, but with a frameshift separating the ORFs is found in MTV012_36/MTV012_35. Sequence similarity is also seen with MTCY251_15; MTCY261_19; MLCB2492_30 from Mycobacterium leprae; MTCY10G2_10; MTY21C12_9; MTCI125_26; MTCY164_36; MTCY6A4_1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a deletion of 1166 bp leads to the loss of the NH2 part of PPE66 and of Rv3739c compared to its homolog in Mycobacterium tuberculosis strain H37Rv.;PPE FAMILY PROTEIN
233413010592	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
233413010593	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
233413010594	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413010595	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413010596	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
233413010597	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
233413010598	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
233413010599	Soluble P-type ATPase [General function prediction only]; Region: COG4087
233413010600	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
233413010601	dimerization interface [polypeptide binding]; other site
233413010602	putative DNA binding site [nucleotide binding]; other site
233413010603	putative Zn2+ binding site [ion binding]; other site
233413010604	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651
233413010605	PIN domain; Region: PIN_3; pfam13470
233413010606	DNA binding domain, excisionase family; Region: excise; TIGR01764
233413010607	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
233413010608	DNA binding site [nucleotide binding]
233413010609	active site
233413010610	Int/Topo IB signature motif; other site
233413010611	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
233413010612	nucleoside/Zn binding site; other site
233413010613	dimer interface [polypeptide binding]; other site
233413010614	catalytic motif [active]
233413010615	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
233413010616	prephenate dehydrogenase; Validated; Region: PRK06545
233413010617	prephenate dehydrogenase; Validated; Region: PRK08507
233413010618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554
233413010619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413010620	dimer interface [polypeptide binding]; other site
233413010621	conserved gate region; other site
233413010622	putative PBP binding loops; other site
233413010623	ABC-ATPase subunit interface; other site
233413010624	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
233413010625	dimer interface [polypeptide binding]; other site
233413010626	conserved gate region; other site
233413010627	putative PBP binding loops; other site
233413010628	ABC-ATPase subunit interface; other site
233413010629	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
233413010630	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
233413010631	Walker A/P-loop; other site
233413010632	ATP binding site [chemical binding]; other site
233413010633	Q-loop/lid; other site
233413010634	ABC transporter signature motif; other site
233413010635	Walker B; other site
233413010636	D-loop; other site
233413010637	H-loop/switch region; other site
233413010638	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
233413010639	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
233413010640	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
233413010641	Phosphotransferase enzyme family; Region: APH; pfam01636
233413010642	putative active site [active]
233413010643	putative substrate binding site [chemical binding]; other site
233413010644	ATP binding site [chemical binding]; other site
233413010645	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
233413010646	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
233413010647	Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863
233413010648	Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864
233413010649	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
233413010650	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
233413010651	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
233413010652	dimerization interface [polypeptide binding]; other site
233413010653	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
233413010654	dimer interface [polypeptide binding]; other site
233413010655	phosphorylation site [posttranslational modification]
233413010656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
233413010657	ATP binding site [chemical binding]; other site
233413010658	Mg2+ binding site [ion binding]; other site
233413010659	G-X-G motif; other site
233413010660	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
233413010661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
233413010662	active site
233413010663	phosphorylation site [posttranslational modification]
233413010664	intermolecular recognition site; other site
233413010665	dimerization interface [polypeptide binding]; other site
233413010666	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
233413010667	DNA binding site [nucleotide binding]
233413010668	Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243
233413010669	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
233413010670	SnoaL-like domain; Region: SnoaL_2; pfam12680
233413010671	putative aminotransferase; Provisional; Region: PRK03321
233413010672	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
233413010673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
233413010674	homodimer interface [polypeptide binding]; other site
233413010675	catalytic residue [active]
233413010676	TIGR03086 family protein; Region: TIGR03086
233413010677	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
233413010678	enoyl-CoA hydratase; Provisional; Region: PRK06142
233413010679	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
233413010680	substrate binding site [chemical binding]; other site
233413010681	oxyanion hole (OAH) forming residues; other site
233413010682	trimer interface [polypeptide binding]; other site
233413010683	Beta-lactamase; Region: Beta-lactamase; pfam00144
233413010684	Domain of unknown function (DUF222); Region: DUF222; pfam02720
233413010685	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
233413010686	active site
233413010687	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
233413010688	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
233413010689	NAD(P) binding site [chemical binding]; other site
233413010690	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
233413010691	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
233413010692	catalytic residue [active]
233413010693	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
233413010694	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
233413010695	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
233413010696	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
233413010697	Walker A/P-loop; other site
233413010698	ATP binding site [chemical binding]; other site
233413010699	Q-loop/lid; other site
233413010700	ABC transporter signature motif; other site
233413010701	Walker B; other site
233413010702	D-loop; other site
233413010703	H-loop/switch region; other site
233413010704	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
233413010705	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
233413010706	active site
233413010707	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
233413010708	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
233413010709	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
233413010710	NAD binding site [chemical binding]; other site
233413010711	substrate binding site [chemical binding]; other site
233413010712	active site
233413010713	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
233413010714	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
233413010715	active site
233413010716	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
233413010717	Peptidase family M23; Region: Peptidase_M23; pfam01551
233413010718	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
233413010719	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
233413010720	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
233413010721	Predicted membrane protein [Function unknown]; Region: COG2246
233413010722	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
233413010723	FAD binding domain; Region: FAD_binding_4; pfam01565
233413010724	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
233413010725	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
233413010726	classical (c) SDRs; Region: SDR_c; cd05233
233413010727	NAD(P) binding site [chemical binding]; other site
233413010728	active site
233413010729	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
233413010730	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
233413010731	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
233413010732	EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896
233413010733	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
233413010734	EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896
233413010735	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
233413010736	EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896
233413010737	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
233413010738	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
233413010739	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
233413010740	FAD binding site [chemical binding]; other site
233413010741	substrate binding site [chemical binding]; other site
233413010742	catalytic residues [active]
233413010743	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
233413010744	zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
233413010745	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
233413010746	Transposase; Region: DDE_Tnp_ISL3; pfam01610
233413010747	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
233413010748	Transposase; Region: DDE_Tnp_ISL3; pfam01610
233413010749	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
233413010750	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
233413010751	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
233413010752	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413010753	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413010754	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413010755	active site
233413010756	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
233413010757	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
233413010758	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
233413010759	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
233413010760	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413010761	acyl-activating enzyme (AAE) consensus motif; other site
233413010762	active site
233413010763	Cutinase; Region: Cutinase; pfam01083
233413010764	Predicted esterase [General function prediction only]; Region: COG0627
233413010765	Predicted esterase [General function prediction only]; Region: COG0627
233413010766	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
233413010767	UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963
233413010768	putative active site [active]
233413010769	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
233413010770	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
233413010771	active site
233413010772	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
233413010773	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
233413010774	active site
233413010775	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
233413010776	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413010777	UDP-galactopyranose mutase; Region: GLF; pfam03275
233413010778	poly-U binding splicing factor, half-pint family; Region: half-pint; TIGR01645
233413010779	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
233413010780	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
233413010781	amidase catalytic site [active]
233413010782	Zn binding residues [ion binding]; other site
233413010783	substrate binding site [chemical binding]; other site
233413010784	LGFP repeat; Region: LGFP; pfam08310
233413010785	PE family; Region: PE; pfam00934
233413010786	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
233413010787	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
233413010788	active site
233413010789	motif I; other site
233413010790	motif II; other site
233413010791	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
233413010792	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
233413010793	putative acyl-acceptor binding pocket; other site
233413010794	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
233413010795	putative acyl-acceptor binding pocket; other site
233413010796	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
233413010797	putative acyl-acceptor binding pocket; other site
233413010798	Aminoglycoside phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: Aph; COG3231
233413010799	Phosphotransferase enzyme family; Region: APH; pfam01636
233413010800	active site
233413010801	ATP binding site [chemical binding]; other site
233413010802	substrate binding site [chemical binding]; other site
233413010803	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
233413010804	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
233413010805	iron-sulfur cluster [ion binding]; other site
233413010806	[2Fe-2S] cluster binding site [ion binding]; other site
233413010807	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
233413010808	Condensation domain; Region: Condensation; cl19241
233413010809	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
233413010810	PE-PPE domain; Region: PE-PPE; pfam08237
233413010811	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
233413010812	MMPL family; Region: MMPL; pfam03176
233413010813	MMPL family; Region: MMPL; pfam03176
233413010814	Condensation domain; Region: Condensation; cl19241
233413010815	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
233413010816	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
233413010817	active site
233413010818	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
233413010819	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
233413010820	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
233413010821	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
233413010822	Enoylreductase; Region: PKS_ER; smart00829
233413010823	NAD(P) binding site [chemical binding]; other site
233413010824	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
233413010825	short chain dehydrogenase; Region: adh_short; pfam00106
233413010826	putative NADP binding site [chemical binding]; other site
233413010827	active site
233413010828	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
233413010829	acyl-CoA synthetase; Validated; Region: PRK05850
233413010830	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
233413010831	acyl-activating enzyme (AAE) consensus motif; other site
233413010832	active site
233413010833	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
233413010834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
233413010835	Probable transposase; Region: OrfB_IS605; pfam01385
233413010836	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
233413010837	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
233413010838	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
233413010839	catalytic residues [active]
233413010840	catalytic nucleophile [active]
233413010841	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
233413010842	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413010843	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
233413010844	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413010845	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
233413010846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
233413010847	S-adenosylmethionine binding site [chemical binding]; other site
233413010848	Cupin domain; Region: Cupin_2; cl17218
233413010849	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
233413010850	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
233413010851	seryl-tRNA synthetase; Provisional; Region: PRK05431
233413010852	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
233413010853	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
233413010854	dimer interface [polypeptide binding]; other site
233413010855	active site
233413010856	motif 1; other site
233413010857	motif 2; other site
233413010858	motif 3; other site
233413010859	Septum formation; Region: Septum_form; pfam13845
233413010860	Septum formation; Region: Septum_form; pfam13845
233413010861	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
233413010862	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
233413010863	catalytic core [active]
233413010864	prephenate dehydratase; Provisional; Region: PRK11898
233413010865	Prephenate dehydratase; Region: PDT; pfam00800
233413010866	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
233413010867	putative L-Phe binding site [chemical binding]; other site
233413010868	Transcriptional regulator [Transcription]; Region: LytR; COG1316
233413010869	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
233413010870	Ferritin-like domain; Region: Ferritin; pfam00210
233413010871	ferroxidase diiron center [ion binding]; other site
233413010872	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
233413010873	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
233413010874	putative active site [active]
233413010875	catalytic site [active]
233413010876	putative metal binding site [ion binding]; other site
233413010877	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
233413010878	Transposase; Region: DEDD_Tnp_IS110; pfam01548
233413010879	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
233413010880	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
233413010881	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
233413010882	Predicted membrane protein [Function unknown]; Region: COG2119
233413010883	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
233413010884	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
233413010885	Fimbrial protein; Region: Fimbrial; cl01416
233413010886	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
233413010887	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
233413010888	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
233413010889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
233413010890	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
233413010891	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
233413010892	hypothetical protein; Provisional; Region: PRK07945
233413010893	Helix-hairpin-helix domain; Region: HHH_8; pfam14716
233413010894	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
233413010895	active site
233413010896	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
233413010897	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
233413010898	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
233413010899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
233413010900	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
233413010901	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
233413010902	active site
233413010903	dimer interface [polypeptide binding]; other site
233413010904	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
233413010905	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
233413010906	active site
233413010907	FMN binding site [chemical binding]; other site
233413010908	substrate binding site [chemical binding]; other site
233413010909	3Fe-4S cluster binding site [ion binding]; other site
233413010910	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
233413010911	domain interface; other site
233413010912	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
233413010913	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
233413010914	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413010915	Transcription factor WhiB; Region: Whib; pfam02467
233413010916	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
233413010917	104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449
233413010918	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
233413010919	EspG family; Region: ESX-1_EspG; pfam14011
233413010920	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
233413010921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010922	Walker A motif; other site
233413010923	ATP binding site [chemical binding]; other site
233413010924	Walker B motif; other site
233413010925	arginine finger; other site
233413010926	Protein of unknown function (DUF690); Region: DUF690; pfam05108
233413010927	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
233413010928	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413010929	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
233413010930	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413010931	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413010932	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010933	Walker A motif; other site
233413010934	ATP binding site [chemical binding]; other site
233413010935	PE family; Region: PE; pfam00934
233413010936	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
233413010937	PPE family; Region: PPE; pfam00823
233413010938	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
233413010939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
233413010940	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
233413010941	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
233413010942	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
233413010943	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
233413010944	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
233413010945	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
233413010946	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
233413010947	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
233413010948	active site
233413010949	catalytic residues [active]
233413010950	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
233413010951	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
233413010952	Walker A motif; other site
233413010953	ATP binding site [chemical binding]; other site
233413010954	Walker B motif; other site
233413010955	arginine finger; other site
233413010956	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
233413010957	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
233413010958	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
233413010959	active site
233413010960	catalytic residues [active]
233413010961	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
233413010962	EspG family; Region: ESX-1_EspG; pfam14011
233413010963	Proteins of 100 residues with WXG; Region: WXG100; cl02005
233413010964	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
233413010965	PPE family; Region: PPE; pfam00823
233413010966	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
233413010967	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413010968	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413010969	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
233413010970	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
233413010971	Protein of unknown function (DUF690); Region: DUF690; pfam05108
233413010972	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
233413010973	catalytic residue [active]
233413010974	Mb3929c, -, len: 247 aa. Equivalent to 5' end of Rv3899c, len: 410 aa, from Mycobacterium tuberculosis strain H37Rv, (90.8% identity in 130 aa overlap). Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 HYPOTHETICAL 15.1 KDA PROTEIN (FRAGMENT) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 HYPOTHETICAL 13.7 KDA PROTEIN (FRAGMENT) (143 aa), FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 HYPOTHETICAL 73.6 KDA PROTEIN (721 aa), FASTA scores: opt: 1388, E(): 1.5e-48, (55.25% identity in 409 aa overlap). And similar to P71599|Rv0029|MTCY10H4.29 HYPOTHETICAL 39.6 KDA PROTEIN (365 aa), FASTA scores: opt: 403, E(): 1.7e-09, (33.75% identity in 252 aa overlap). Note that MTCY15F10.12 and MTCY15F10.13 appear frameshifted with respect to MTCY49.21 although the sequence appears to be correct. In Mycobacterium tuberculosis strain H37Rv, Rv3899c (len: 410 aa) exists as a single gene on a single reading frame. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product.;CONSERVED HYPOTHETICAL PROTEIN
233413010975	Immunity protein 37; Region: Imm37; pfam15598
233413010976	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
233413010977	Proteins of 100 residues with WXG; Region: WXG100; cl02005
233413010978	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
233413010979	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
233413010980	active site
233413010981	NTP binding site [chemical binding]; other site
233413010982	metal binding triad [ion binding]; metal-binding site
233413010983	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
233413010984	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
233413010985	Zn2+ binding site [ion binding]; other site
233413010986	Mg2+ binding site [ion binding]; other site
233413010987	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
233413010988	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
233413010989	active site
233413010990	Ap6A binding site [chemical binding]; other site
233413010991	nudix motif; other site
233413010992	metal binding site [ion binding]; metal-binding site
233413010993	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
233413010994	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
233413010995	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
233413010996	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
233413010997	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
233413010998	DNA binding residues [nucleotide binding]
233413010999	Mb3942, sigMb, len: 62 aa. Equivalent to 3' end of Rv3911, len: 222 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 62 aa overlap). Possible sigM, alternative RNA polymerase sigma factor (see citation below), highly similar to others e.g. Q9S6U3|SCH24.14c (alias O86856|SIGT)  RNA POLYMERASE SIGMA FACTOR from Streptomyces coelicolor (236 aa), FASTA scores: opt: 336, E(): 2.8e-13, (41.5% identity in 212 aa overlap); Q98KG8|MLR1481 PROBABLE RNA POLYMERASE SIGMA SUBUNIT from Rhizobium loti (Mesorhizobium loti) (307 aa), FASTA scores: opt: 221, E(): 2.9e-06, (32.95% identity in 179 aa overlap); Q9A4S9|CC2751  RNA POLYMERASE SIGMA FACTOR from Caulobacter crescentus (186 aa), FASTA scores: opt: 217, E(): 3.3e-06, (36.95% identity in 138 aa overlap); etc. Also similarity with other mycobacterial factors e.g. O06289|SIGE|Rv1221|MTCI61.04  RNA POLYMERASE SIGMA FACTOR from Mycobacterium tuberculosis (257 aa), FASTA scores: opt: 193, E(): 0.00012, (33.15% identity in 163 aa overlap); and O05735|SIGE  RNA POLYMERASE SIGMA FACTOR from Mycobacterium avium (251 aa), FASTA scores: opt: 192, E(): 0.00014, (33.15% identity in 163 aa overlap). Equivalent to AAK48395|MT4030 RNA POLYMERASE SIGMA-70 FACTOR from Mycobacterium tuberculosis strain CDC1551 (196 aa) but without similarity at the C-terminal end. BELONGS TO THE SIGMA-70 FACTOR FAMILY, ECF SUBFAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis, sigM exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2bp to 1bp substitution (cg-t) splits sigM into 2 parts, sigMa and sigMb.;POSSIBLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGMb [SECOND PART]
233413011000	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
233413011001	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
233413011002	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
233413011003	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
233413011004	catalytic residues [active]
233413011005	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
233413011006	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
233413011007	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
233413011008	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
233413011009	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
233413011010	active site
233413011011	metal binding site [ion binding]; metal-binding site
233413011012	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
233413011013	ParB-like nuclease domain; Region: ParBc; pfam02195
233413011014	KorB domain; Region: KorB; pfam08535
233413011015	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
233413011016	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
233413011017	P-loop; other site
233413011018	Magnesium ion binding site [ion binding]; other site
233413011019	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
233413011020	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
233413011021	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
233413011022	G-X-X-G motif; other site
233413011023	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
233413011024	RxxxH motif; other site
233413011025	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
233413011026	Uncharacterized conserved protein [Function unknown]; Region: COG0759
233413011027	ribonuclease P; Reviewed; Region: rnpA; PRK00588
233413011028	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399