-- dump date 20140619_151144 -- class Genbank::misc_feature -- table misc_feature_note -- id note 262316000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 262316000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316000003 Walker A motif; other site 262316000004 ATP binding site [chemical binding]; other site 262316000005 Walker B motif; other site 262316000006 arginine finger; other site 262316000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 262316000008 DnaA box-binding interface [nucleotide binding]; other site 262316000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 262316000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 262316000011 putative DNA binding surface [nucleotide binding]; other site 262316000012 dimer interface [polypeptide binding]; other site 262316000013 beta-clamp/clamp loader binding surface; other site 262316000014 beta-clamp/translesion DNA polymerase binding surface; other site 262316000015 recombination protein F; Reviewed; Region: recF; PRK00064 262316000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 262316000017 Walker A/P-loop; other site 262316000018 ATP binding site [chemical binding]; other site 262316000019 Q-loop/lid; other site 262316000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316000021 ABC transporter signature motif; other site 262316000022 Walker B; other site 262316000023 D-loop; other site 262316000024 H-loop/switch region; other site 262316000025 hypothetical protein; Provisional; Region: PRK03195 262316000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 262316000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316000028 Mg2+ binding site [ion binding]; other site 262316000029 G-X-G motif; other site 262316000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 262316000031 anchoring element; other site 262316000032 dimer interface [polypeptide binding]; other site 262316000033 ATP binding site [chemical binding]; other site 262316000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 262316000035 active site 262316000036 putative metal-binding site [ion binding]; other site 262316000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 262316000038 DNA gyrase subunit A; Validated; Region: PRK05560 262316000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 262316000040 CAP-like domain; other site 262316000041 active site 262316000042 primary dimer interface [polypeptide binding]; other site 262316000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262316000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 262316000050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000052 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316000053 Cytochrome P450; Region: p450; cl12078 262316000054 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 262316000055 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 262316000056 active site 262316000057 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 262316000058 putative septation inhibitor protein; Reviewed; Region: PRK00159 262316000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 262316000060 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 262316000061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 262316000062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 262316000063 glutamine binding [chemical binding]; other site 262316000064 catalytic triad [active] 262316000065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316000066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316000067 active site 262316000068 ATP binding site [chemical binding]; other site 262316000069 substrate binding site [chemical binding]; other site 262316000070 activation loop (A-loop); other site 262316000071 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316000072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 262316000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262316000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262316000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262316000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262316000077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316000078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316000079 active site 262316000080 ATP binding site [chemical binding]; other site 262316000081 substrate binding site [chemical binding]; other site 262316000082 activation loop (A-loop); other site 262316000083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 262316000084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 262316000085 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 262316000086 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 262316000087 active site 262316000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316000089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316000090 phosphopeptide binding site; other site 262316000091 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 262316000092 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316000093 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316000094 phosphopeptide binding site; other site 262316000095 DinB superfamily; Region: DinB_2; pfam12867 262316000096 acyl carrier protein; Validated; Region: PRK05883 262316000097 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 262316000098 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316000099 acyl-activating enzyme (AAE) consensus motif; other site 262316000100 AMP binding site [chemical binding]; other site 262316000101 active site 262316000102 CoA binding site [chemical binding]; other site 262316000103 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 262316000104 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316000105 MULE transposase domain; Region: MULE; pfam10551 262316000106 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316000107 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316000108 active site 262316000109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316000110 Coenzyme A binding pocket [chemical binding]; other site 262316000111 Pirin-related protein [General function prediction only]; Region: COG1741 262316000112 Pirin; Region: Pirin; pfam02678 262316000113 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 262316000114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316000115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000116 active site 262316000117 Transcription factor WhiB; Region: Whib; pfam02467 262316000118 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316000119 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316000120 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316000121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316000122 non-specific DNA binding site [nucleotide binding]; other site 262316000123 salt bridge; other site 262316000124 sequence-specific DNA binding site [nucleotide binding]; other site 262316000125 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262316000126 NlpC/P60 family; Region: NLPC_P60; pfam00877 262316000127 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 262316000128 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 262316000129 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 262316000130 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 262316000131 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 262316000132 TIGR03084 family protein; Region: TIGR03084 262316000133 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 262316000134 Wyosine base formation; Region: Wyosine_form; pfam08608 262316000135 H+ Antiporter protein; Region: 2A0121; TIGR00900 262316000136 hypothetical protein; Validated; Region: PRK00228 262316000137 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 262316000138 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 262316000139 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316000140 active site 262316000141 HIGH motif; other site 262316000142 nucleotide binding site [chemical binding]; other site 262316000143 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 262316000144 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316000145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316000146 active site 262316000147 KMSKS motif; other site 262316000148 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 262316000149 tRNA binding surface [nucleotide binding]; other site 262316000150 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262316000151 short chain dehydrogenase; Provisional; Region: PRK08219 262316000152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000153 NAD(P) binding site [chemical binding]; other site 262316000154 active site 262316000155 Transcriptional regulators [Transcription]; Region: MarR; COG1846 262316000156 MarR family; Region: MarR; pfam01047 262316000157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316000158 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 262316000159 Walker A/P-loop; other site 262316000160 ATP binding site [chemical binding]; other site 262316000161 Q-loop/lid; other site 262316000162 ABC transporter signature motif; other site 262316000163 Walker B; other site 262316000164 D-loop; other site 262316000165 H-loop/switch region; other site 262316000166 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262316000167 substrate binding pocket [chemical binding]; other site 262316000168 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262316000169 membrane-bound complex binding site; other site 262316000170 hinge residues; other site 262316000171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316000172 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 262316000173 dimer interface [polypeptide binding]; other site 262316000174 conserved gate region; other site 262316000175 putative PBP binding loops; other site 262316000176 ABC-ATPase subunit interface; other site 262316000177 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316000178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316000179 DNA-binding site [nucleotide binding]; DNA binding site 262316000180 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 262316000181 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000182 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316000183 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 262316000184 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 262316000185 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 262316000186 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316000187 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000188 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 262316000189 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 262316000190 Predicted transcriptional regulators [Transcription]; Region: COG1695 262316000191 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 262316000192 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 262316000193 Transglycosylase; Region: Transgly; pfam00912 262316000194 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 262316000195 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 262316000196 Predicted integral membrane protein [Function unknown]; Region: COG5650 262316000197 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 262316000198 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 262316000199 conserved cys residue [active] 262316000200 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 262316000201 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 262316000202 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 262316000203 dimer interface [polypeptide binding]; other site 262316000204 ssDNA binding site [nucleotide binding]; other site 262316000205 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262316000206 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 262316000207 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 262316000208 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 262316000209 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 262316000210 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 262316000211 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 262316000212 Walker A motif; other site 262316000213 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 262316000214 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 262316000215 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 262316000216 ATP binding site [chemical binding]; other site 262316000217 Walker B motif; other site 262316000218 DNA binding loops [nucleotide binding] 262316000219 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316000220 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316000221 putative acyl-acceptor binding pocket; other site 262316000222 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262316000223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316000224 S-adenosylmethionine binding site [chemical binding]; other site 262316000225 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 262316000226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000227 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316000228 Transport protein; Region: actII; TIGR00833 262316000229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316000230 classical (c) SDRs; Region: SDR_c; cd05233 262316000231 NAD(P) binding site [chemical binding]; other site 262316000232 active site 262316000233 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316000234 FAD binding domain; Region: FAD_binding_4; pfam01565 262316000235 Berberine and berberine like; Region: BBE; pfam08031 262316000236 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262316000237 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316000238 ligand binding site [chemical binding]; other site 262316000239 flexible hinge region; other site 262316000240 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 262316000241 putative switch regulator; other site 262316000242 non-specific DNA interactions [nucleotide binding]; other site 262316000243 DNA binding site [nucleotide binding] 262316000244 sequence specific DNA binding site [nucleotide binding]; other site 262316000245 putative cAMP binding site [chemical binding]; other site 262316000246 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316000247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316000248 active site 262316000249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316000250 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316000251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316000252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316000253 dimerization interface [polypeptide binding]; other site 262316000254 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 262316000255 EamA-like transporter family; Region: EamA; pfam00892 262316000256 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 262316000257 conserved hypothetical protein; Region: TIGR02246 262316000258 SnoaL-like domain; Region: SnoaL_3; pfam13474 262316000259 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 262316000260 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262316000261 Permease; Region: Permease; pfam02405 262316000262 Permease; Region: Permease; pfam02405 262316000263 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 262316000264 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 262316000265 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 262316000266 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 262316000267 putative di-iron ligands [ion binding]; other site 262316000268 tetracycline repressor protein TetR; Provisional; Region: PRK13756 262316000269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000270 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 262316000271 CsbD-like; Region: CsbD; pfam05532 262316000272 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316000273 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316000274 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316000275 MULE transposase domain; Region: MULE; pfam10551 262316000276 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 262316000277 active site 262316000278 Int/Topo IB signature motif; other site 262316000279 catalytic residues [active] 262316000280 DNA binding site [nucleotide binding] 262316000281 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 262316000282 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316000283 active site 262316000284 DNA binding site [nucleotide binding] 262316000285 Int/Topo IB signature motif; other site 262316000286 Permease; Region: Permease; pfam02405 262316000287 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 262316000288 mce related protein; Region: MCE; pfam02470 262316000289 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316000290 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 262316000291 mce related protein; Region: MCE; pfam02470 262316000292 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000293 mce related protein; Region: MCE; pfam02470 262316000294 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000295 mce related protein; Region: MCE; pfam02470 262316000296 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 262316000297 mce related protein; Region: MCE; pfam02470 262316000298 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316000299 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316000300 mce related protein; Region: MCE; pfam02470 262316000301 Mannan-binding protein; Region: MVL; pfam12151 262316000302 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 262316000303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000307 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 262316000308 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316000309 PPE family; Region: PPE; pfam00823 262316000310 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 262316000311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316000312 S-adenosylmethionine binding site [chemical binding]; other site 262316000313 Domain of unknown function (DUF385); Region: DUF385; pfam04075 262316000314 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 262316000315 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 262316000316 Sulfate transporter family; Region: Sulfate_transp; pfam00916 262316000317 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000318 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316000319 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 262316000320 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 262316000321 putative ligand binding site [chemical binding]; other site 262316000322 NAD binding site [chemical binding]; other site 262316000323 catalytic site [active] 262316000324 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 262316000325 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316000326 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316000327 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 262316000328 PhoU domain; Region: PhoU; pfam01895 262316000329 proline/glycine betaine transporter; Provisional; Region: PRK10642 262316000330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316000331 putative substrate translocation pore; other site 262316000332 Hemerythrin-like domain; Region: Hr-like; cd12108 262316000333 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316000334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316000335 S-adenosylmethionine binding site [chemical binding]; other site 262316000336 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316000337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316000338 active site 262316000339 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 262316000340 Predicted transcriptional regulators [Transcription]; Region: COG1695 262316000341 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 262316000342 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 262316000343 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316000344 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 262316000345 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316000347 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 262316000348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316000349 Walker A/P-loop; other site 262316000350 ATP binding site [chemical binding]; other site 262316000351 Q-loop/lid; other site 262316000352 ABC transporter signature motif; other site 262316000353 Walker B; other site 262316000354 D-loop; other site 262316000355 H-loop/switch region; other site 262316000356 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 262316000357 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262316000358 substrate binding pocket [chemical binding]; other site 262316000359 membrane-bound complex binding site; other site 262316000360 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 262316000361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316000362 dimer interface [polypeptide binding]; other site 262316000363 conserved gate region; other site 262316000364 putative PBP binding loops; other site 262316000365 ABC-ATPase subunit interface; other site 262316000366 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262316000367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316000368 hypothetical protein; Provisional; Region: PRK01346 262316000369 hypothetical protein; Provisional; Region: PRK01346 262316000370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316000371 Coenzyme A binding pocket [chemical binding]; other site 262316000372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316000373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000374 active site 262316000375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316000378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316000379 dimer interface [polypeptide binding]; other site 262316000380 phosphorylation site [posttranslational modification] 262316000381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316000382 ATP binding site [chemical binding]; other site 262316000383 Mg2+ binding site [ion binding]; other site 262316000384 G-X-G motif; other site 262316000385 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316000386 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316000387 substrate binding site [chemical binding]; other site 262316000388 oxyanion hole (OAH) forming residues; other site 262316000389 trimer interface [polypeptide binding]; other site 262316000390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000392 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 262316000393 putative dimer interface [polypeptide binding]; other site 262316000394 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316000395 ligand binding site [chemical binding]; other site 262316000396 Zn binding site [ion binding]; other site 262316000397 PPE family; Region: PPE; pfam00823 262316000398 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316000399 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316000400 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316000401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 262316000402 EspG family; Region: ESX-1_EspG; pfam14011 262316000403 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316000404 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 262316000405 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 262316000406 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316000407 catalytic residues [active] 262316000408 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 262316000409 active site 262316000410 catalytic residues [active] 262316000411 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 262316000412 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 262316000413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316000414 Walker A motif; other site 262316000415 ATP binding site [chemical binding]; other site 262316000416 Walker B motif; other site 262316000417 arginine finger; other site 262316000418 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316000419 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 262316000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000421 NAD(P) binding site [chemical binding]; other site 262316000422 active site 262316000423 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 262316000424 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316000425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316000426 DNA binding residues [nucleotide binding] 262316000427 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316000428 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 262316000429 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 262316000430 active site 262316000431 dimer interface [polypeptide binding]; other site 262316000432 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 262316000433 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 262316000434 active site 262316000435 FMN binding site [chemical binding]; other site 262316000436 substrate binding site [chemical binding]; other site 262316000437 3Fe-4S cluster binding site [ion binding]; other site 262316000438 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 262316000439 domain interface; other site 262316000440 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 262316000441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316000442 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316000443 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000444 hypothetical protein; Provisional; Region: PRK07945 262316000445 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 262316000446 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 262316000447 active site 262316000448 DNA polymerase IV; Validated; Region: PRK03858 262316000449 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262316000450 active site 262316000451 DNA binding site [nucleotide binding] 262316000452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000454 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316000455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316000456 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 262316000457 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 262316000458 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 262316000459 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 262316000460 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 262316000461 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 262316000462 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 262316000463 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 262316000464 putative active site [active] 262316000465 catalytic site [active] 262316000466 putative metal binding site [ion binding]; other site 262316000467 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 262316000468 prephenate dehydratase; Provisional; Region: PRK11898 262316000469 Prephenate dehydratase; Region: PDT; pfam00800 262316000470 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 262316000471 putative L-Phe binding site [chemical binding]; other site 262316000472 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 262316000473 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316000474 catalytic core [active] 262316000475 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 262316000476 Septum formation; Region: Septum_form; pfam13845 262316000477 Septum formation; Region: Septum_form; pfam13845 262316000478 seryl-tRNA synthetase; Provisional; Region: PRK05431 262316000479 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 262316000480 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 262316000481 dimer interface [polypeptide binding]; other site 262316000482 active site 262316000483 motif 1; other site 262316000484 motif 2; other site 262316000485 motif 3; other site 262316000486 Cupin domain; Region: Cupin_2; cl17218 262316000487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316000488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262316000489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316000490 S-adenosylmethionine binding site [chemical binding]; other site 262316000491 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 262316000492 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316000493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000494 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316000495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316000496 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 262316000497 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 262316000498 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316000499 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 262316000500 iron-sulfur cluster [ion binding]; other site 262316000501 [2Fe-2S] cluster binding site [ion binding]; other site 262316000502 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316000503 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316000504 putative acyl-acceptor binding pocket; other site 262316000505 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316000506 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316000507 putative acyl-acceptor binding pocket; other site 262316000508 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316000509 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316000510 putative acyl-acceptor binding pocket; other site 262316000511 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262316000512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316000513 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 262316000514 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 262316000515 amidase catalytic site [active] 262316000516 Zn binding residues [ion binding]; other site 262316000517 substrate binding site [chemical binding]; other site 262316000518 LGFP repeat; Region: LGFP; pfam08310 262316000519 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 262316000520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316000521 UDP-galactopyranose mutase; Region: GLF; pfam03275 262316000522 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 262316000523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 262316000524 active site 262316000525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316000526 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 262316000527 Putative esterase; Region: Esterase; pfam00756 262316000528 Putative esterase; Region: Esterase; pfam00756 262316000529 Cutinase; Region: Cutinase; pfam01083 262316000530 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 262316000531 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316000532 acyl-activating enzyme (AAE) consensus motif; other site 262316000533 active site 262316000534 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316000535 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316000536 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316000537 active site 262316000538 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316000539 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316000540 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316000541 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 262316000542 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316000543 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262316000544 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316000545 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316000546 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316000547 Helix-turn-helix domain; Region: HTH_18; pfam12833 262316000548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316000549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000550 active site 262316000551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316000552 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 262316000553 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 262316000554 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 262316000555 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 262316000556 AsnC family; Region: AsnC_trans_reg; pfam01037 262316000557 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316000558 NSP11; Region: NSP11; pfam06471 262316000559 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 262316000560 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 262316000561 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 262316000562 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 262316000563 DNA binding site [nucleotide binding] 262316000564 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316000565 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316000566 phosphopeptide binding site; other site 262316000567 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 262316000568 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 262316000569 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 262316000570 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 262316000571 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 262316000572 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 262316000573 short chain dehydrogenase; Provisional; Region: PRK07904 262316000574 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316000575 NAD(P) binding site [chemical binding]; other site 262316000576 active site 262316000577 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316000578 FAD binding domain; Region: FAD_binding_4; pfam01565 262316000579 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 262316000580 Predicted membrane protein [Function unknown]; Region: COG2246 262316000581 GtrA-like protein; Region: GtrA; pfam04138 262316000582 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 262316000583 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 262316000584 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 262316000585 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 262316000586 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 262316000587 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 262316000588 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 262316000589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316000590 active site 262316000591 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 262316000592 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 262316000593 Walker A/P-loop; other site 262316000594 ATP binding site [chemical binding]; other site 262316000595 Q-loop/lid; other site 262316000596 ABC transporter signature motif; other site 262316000597 Walker B; other site 262316000598 D-loop; other site 262316000599 H-loop/switch region; other site 262316000600 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 262316000601 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316000602 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000604 catalytic residue [active] 262316000605 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 262316000606 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 262316000607 NAD(P) binding site [chemical binding]; other site 262316000608 peptide chain release factor 1, archaeal and eukaryotic forms; Region: aRF1/eRF1; TIGR03676 262316000609 eRF1 domain 3; Region: eRF1_3; pfam03465 262316000610 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316000611 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316000612 enoyl-CoA hydratase; Provisional; Region: PRK06142 262316000613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316000614 substrate binding site [chemical binding]; other site 262316000615 oxyanion hole (OAH) forming residues; other site 262316000616 trimer interface [polypeptide binding]; other site 262316000617 TIGR03086 family protein; Region: TIGR03086 262316000618 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 262316000619 GXWXG protein; Region: GXWXG; pfam14231 262316000620 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 262316000621 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 262316000622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316000623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316000624 homodimer interface [polypeptide binding]; other site 262316000625 catalytic residue [active] 262316000626 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 262316000627 Winged helix-turn helix; Region: HTH_29; pfam13551 262316000628 DNA-binding interface [nucleotide binding]; DNA binding site 262316000629 Homeodomain-like domain; Region: HTH_32; pfam13565 262316000630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316000631 Integrase core domain; Region: rve; pfam00665 262316000632 Integrase core domain; Region: rve_3; pfam13683 262316000633 Phosphotransferase enzyme family; Region: APH; pfam01636 262316000634 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 262316000635 putative active site [active] 262316000636 putative substrate binding site [chemical binding]; other site 262316000637 ATP binding site [chemical binding]; other site 262316000638 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316000639 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316000640 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316000641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316000642 active site 262316000643 phosphorylation site [posttranslational modification] 262316000644 intermolecular recognition site; other site 262316000645 dimerization interface [polypeptide binding]; other site 262316000646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316000647 DNA binding site [nucleotide binding] 262316000648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316000649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316000650 dimerization interface [polypeptide binding]; other site 262316000651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316000652 dimer interface [polypeptide binding]; other site 262316000653 phosphorylation site [posttranslational modification] 262316000654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316000655 ATP binding site [chemical binding]; other site 262316000656 Mg2+ binding site [ion binding]; other site 262316000657 G-X-G motif; other site 262316000658 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316000659 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 262316000660 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316000661 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262316000662 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 262316000663 NAD(P) binding site [chemical binding]; other site 262316000664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000666 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316000667 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316000668 active site 262316000669 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 262316000670 classical (c) SDRs; Region: SDR_c; cd05233 262316000671 NAD(P) binding site [chemical binding]; other site 262316000672 active site 262316000673 Phosphotransferase enzyme family; Region: APH; pfam01636 262316000674 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 262316000675 putative active site [active] 262316000676 putative substrate binding site [chemical binding]; other site 262316000677 ATP binding site [chemical binding]; other site 262316000678 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 262316000679 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316000680 catalytic core [active] 262316000681 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 262316000682 putative active site [active] 262316000683 putative substrate binding site [chemical binding]; other site 262316000684 ATP binding site [chemical binding]; other site 262316000685 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 262316000686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316000687 Walker A/P-loop; other site 262316000688 ATP binding site [chemical binding]; other site 262316000689 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 262316000690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316000691 ABC transporter signature motif; other site 262316000692 Walker B; other site 262316000693 D-loop; other site 262316000694 H-loop/switch region; other site 262316000695 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 262316000696 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 262316000697 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 262316000698 prephenate dehydrogenase; Validated; Region: PRK06545 262316000699 prephenate dehydrogenase; Validated; Region: PRK08507 262316000700 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 262316000701 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 262316000702 nucleoside/Zn binding site; other site 262316000703 dimer interface [polypeptide binding]; other site 262316000704 catalytic motif [active] 262316000705 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 262316000706 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 262316000707 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 262316000708 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 262316000709 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 262316000710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316000711 active site 262316000712 metal binding site [ion binding]; metal-binding site 262316000713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 262316000714 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316000715 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316000716 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316000717 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 262316000718 pyruvate carboxylase; Reviewed; Region: PRK12999 262316000719 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316000720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316000721 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 262316000722 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 262316000723 active site 262316000724 catalytic residues [active] 262316000725 metal binding site [ion binding]; metal-binding site 262316000726 homodimer binding site [polypeptide binding]; other site 262316000727 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262316000728 carboxyltransferase (CT) interaction site; other site 262316000729 biotinylation site [posttranslational modification]; other site 262316000730 citrate synthase; Provisional; Region: PRK14033 262316000731 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 262316000732 dimer interface [polypeptide binding]; other site 262316000733 active site 262316000734 citrylCoA binding site [chemical binding]; other site 262316000735 oxalacetate/citrate binding site [chemical binding]; other site 262316000736 coenzyme A binding site [chemical binding]; other site 262316000737 catalytic triad [active] 262316000738 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 262316000739 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316000740 tetramer interface [polypeptide binding]; other site 262316000741 active site 262316000742 Mg2+/Mn2+ binding site [ion binding]; other site 262316000743 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 262316000744 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316000745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316000746 non-specific DNA binding site [nucleotide binding]; other site 262316000747 salt bridge; other site 262316000748 sequence-specific DNA binding site [nucleotide binding]; other site 262316000749 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 262316000750 Domain of unknown function (DUF955); Region: DUF955; pfam06114 262316000751 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 262316000752 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 262316000753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262316000754 substrate binding site [chemical binding]; other site 262316000755 dimer interface [polypeptide binding]; other site 262316000756 ATP binding site [chemical binding]; other site 262316000757 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 262316000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316000759 S-adenosylmethionine binding site [chemical binding]; other site 262316000760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000761 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316000762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000763 catalytic residue [active] 262316000764 Uncharacterized conserved protein [Function unknown]; Region: COG4301 262316000765 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 262316000766 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 262316000767 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 262316000768 putative active site [active] 262316000769 putative dimer interface [polypeptide binding]; other site 262316000770 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 262316000771 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 262316000772 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 262316000773 PknH-like extracellular domain; Region: PknH_C; pfam14032 262316000774 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 262316000775 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 262316000776 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 262316000777 aspartate kinase; Reviewed; Region: PRK06635 262316000778 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 262316000779 putative nucleotide binding site [chemical binding]; other site 262316000780 putative catalytic residues [active] 262316000781 putative Mg ion binding site [ion binding]; other site 262316000782 putative aspartate binding site [chemical binding]; other site 262316000783 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 262316000784 putative allosteric regulatory site; other site 262316000785 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 262316000786 putative allosteric regulatory residue; other site 262316000787 2-isopropylmalate synthase; Validated; Region: PRK03739 262316000788 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 262316000789 active site 262316000790 catalytic residues [active] 262316000791 metal binding site [ion binding]; metal-binding site 262316000792 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 262316000793 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 262316000794 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 262316000795 active site 262316000796 catalytic site [active] 262316000797 substrate binding site [chemical binding]; other site 262316000798 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 262316000799 Dimer interface [polypeptide binding]; other site 262316000800 BRCT sequence motif; other site 262316000801 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 262316000802 catalytic triad [active] 262316000803 recombination protein RecR; Reviewed; Region: recR; PRK00076 262316000804 RecR protein; Region: RecR; pfam02132 262316000805 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 262316000806 putative active site [active] 262316000807 putative metal-binding site [ion binding]; other site 262316000808 tetramer interface [polypeptide binding]; other site 262316000809 hypothetical protein; Validated; Region: PRK00153 262316000810 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 262316000811 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262316000812 active site 262316000813 metal binding site [ion binding]; metal-binding site 262316000814 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 262316000815 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316000816 FAD binding domain; Region: FAD_binding_4; pfam01565 262316000817 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316000818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316000819 S-adenosylmethionine binding site [chemical binding]; other site 262316000820 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 262316000821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316000822 Walker A motif; other site 262316000823 ATP binding site [chemical binding]; other site 262316000824 Walker B motif; other site 262316000825 arginine finger; other site 262316000826 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 262316000827 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 262316000828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000830 catalytic residue [active] 262316000831 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316000832 CHAT domain; Region: CHAT; cl17868 262316000833 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316000834 Cutinase; Region: Cutinase; pfam01083 262316000835 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 262316000836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316000837 NAD(P) binding site [chemical binding]; other site 262316000838 active site 262316000839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316000840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000841 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316000842 Cytochrome P450; Region: p450; cl12078 262316000843 Transposase domain (DUF772); Region: DUF772; pfam05598 262316000844 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 262316000845 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 262316000846 nucleotide binding site [chemical binding]; other site 262316000847 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 262316000848 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 262316000849 active site 262316000850 DNA binding site [nucleotide binding] 262316000851 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 262316000852 DNA binding site [nucleotide binding] 262316000853 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316000854 Cytochrome P450; Region: p450; cl12078 262316000855 haloalkane dehalogenase; Provisional; Region: PRK00870 262316000856 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 262316000857 nudix motif; other site 262316000858 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316000859 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316000860 short chain dehydrogenase; Provisional; Region: PRK07856 262316000861 classical (c) SDRs; Region: SDR_c; cd05233 262316000862 NAD(P) binding site [chemical binding]; other site 262316000863 active site 262316000864 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316000865 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 262316000866 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316000867 classical (c) SDRs; Region: SDR_c; cd05233 262316000868 NAD(P) binding site [chemical binding]; other site 262316000869 active site 262316000870 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316000871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316000872 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 262316000873 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 262316000874 NAD binding site [chemical binding]; other site 262316000875 dimerization interface [polypeptide binding]; other site 262316000876 ligand binding site [chemical binding]; other site 262316000877 catalytic site [active] 262316000878 glycerol kinase; Provisional; Region: glpK; PRK00047 262316000879 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316000880 nucleotide binding site [chemical binding]; other site 262316000881 Predicted transcriptional regulators [Transcription]; Region: COG1695 262316000882 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 262316000883 Predicted membrane protein/domain [Function unknown]; Region: COG1714 262316000884 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 262316000885 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262316000886 Protein of unknown function DUF58; Region: DUF58; pfam01882 262316000887 MoxR-like ATPases [General function prediction only]; Region: COG0714 262316000888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 262316000889 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 262316000890 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 262316000891 Yqey-like protein; Region: YqeY; pfam09424 262316000892 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 262316000893 G1 box; other site 262316000894 putative GEF interaction site [polypeptide binding]; other site 262316000895 GTP/Mg2+ binding site [chemical binding]; other site 262316000896 Switch I region; other site 262316000897 G2 box; other site 262316000898 G3 box; other site 262316000899 Switch II region; other site 262316000900 G4 box; other site 262316000901 G5 box; other site 262316000902 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 262316000903 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 262316000904 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316000905 selenocysteine synthase; Provisional; Region: PRK04311 262316000906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000907 catalytic residue [active] 262316000908 selenophosphate synthetase; Provisional; Region: PRK00943 262316000909 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 262316000910 dimerization interface [polypeptide binding]; other site 262316000911 putative ATP binding site [chemical binding]; other site 262316000912 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316000913 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316000914 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316000915 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316000916 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 262316000917 molybdopterin cofactor binding site; other site 262316000918 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 262316000919 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 262316000920 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316000921 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 262316000922 intracellular protease, PfpI family; Region: PfpI; TIGR01382 262316000923 proposed catalytic triad [active] 262316000924 conserved cys residue [active] 262316000925 putative methyltransferase; Provisional; Region: PRK14967 262316000926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316000927 S-adenosylmethionine binding site [chemical binding]; other site 262316000928 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 262316000929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316000930 PAS domain; Region: PAS_9; pfam13426 262316000931 putative active site [active] 262316000932 heme pocket [chemical binding]; other site 262316000933 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 262316000934 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 262316000935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 262316000936 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 262316000937 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 262316000938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316000939 ATP binding site [chemical binding]; other site 262316000940 G-X-G motif; other site 262316000941 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 262316000942 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 262316000943 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 262316000944 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316000945 anti sigma factor interaction site; other site 262316000946 regulatory phosphorylation site [posttranslational modification]; other site 262316000947 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 262316000948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316000949 motif II; other site 262316000950 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 262316000951 Restriction endonuclease; Region: Mrr_cat; pfam04471 262316000952 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316000953 GAF domain; Region: GAF; pfam01590 262316000954 ANTAR domain; Region: ANTAR; pfam03861 262316000955 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 262316000956 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 262316000957 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 262316000958 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316000959 catalytic residue [active] 262316000960 phosphodiesterase YaeI; Provisional; Region: PRK11340 262316000961 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 262316000962 putative active site [active] 262316000963 putative metal binding site [ion binding]; other site 262316000964 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 262316000965 Transglycosylase; Region: Transgly; pfam00912 262316000966 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 262316000967 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 262316000968 Transcription factor WhiB; Region: Whib; pfam02467 262316000969 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 262316000970 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316000971 DTAP/Switch II; other site 262316000972 Switch I; other site 262316000973 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316000974 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 262316000975 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316000976 P loop; other site 262316000977 Nucleotide binding site [chemical binding]; other site 262316000978 DTAP/Switch II; other site 262316000979 Switch I; other site 262316000980 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 262316000981 homotrimer interaction site [polypeptide binding]; other site 262316000982 putative active site [active] 262316000983 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316000984 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262316000985 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316000986 ligand binding site [chemical binding]; other site 262316000987 flexible hinge region; other site 262316000988 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 262316000989 putative switch regulator; other site 262316000990 non-specific DNA interactions [nucleotide binding]; other site 262316000991 DNA binding site [nucleotide binding] 262316000992 sequence specific DNA binding site [nucleotide binding]; other site 262316000993 putative cAMP binding site [chemical binding]; other site 262316000994 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 262316000995 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316000996 minor groove reading motif; other site 262316000997 helix-hairpin-helix signature motif; other site 262316000998 substrate binding pocket [chemical binding]; other site 262316000999 active site 262316001000 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 262316001001 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 262316001002 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262316001003 catalytic residues [active] 262316001004 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 262316001005 putative active site [active] 262316001006 putative CoA binding site [chemical binding]; other site 262316001007 nudix motif; other site 262316001008 metal binding site [ion binding]; metal-binding site 262316001009 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 262316001010 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262316001011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316001012 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 262316001013 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262316001014 acetyl-CoA synthetase; Provisional; Region: PRK00174 262316001015 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 262316001016 active site 262316001017 CoA binding site [chemical binding]; other site 262316001018 acyl-activating enzyme (AAE) consensus motif; other site 262316001019 AMP binding site [chemical binding]; other site 262316001020 acetate binding site [chemical binding]; other site 262316001021 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 262316001022 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262316001023 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 262316001024 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262316001025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316001026 dimer interface [polypeptide binding]; other site 262316001027 conserved gate region; other site 262316001028 ABC-ATPase subunit interface; other site 262316001029 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 262316001030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316001031 dimer interface [polypeptide binding]; other site 262316001032 conserved gate region; other site 262316001033 putative PBP binding loops; other site 262316001034 ABC-ATPase subunit interface; other site 262316001035 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 262316001036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262316001037 Walker A/P-loop; other site 262316001038 ATP binding site [chemical binding]; other site 262316001039 Q-loop/lid; other site 262316001040 ABC transporter signature motif; other site 262316001041 Walker B; other site 262316001042 D-loop; other site 262316001043 H-loop/switch region; other site 262316001044 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316001045 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262316001046 Walker A/P-loop; other site 262316001047 ATP binding site [chemical binding]; other site 262316001048 Q-loop/lid; other site 262316001049 ABC transporter signature motif; other site 262316001050 Walker B; other site 262316001051 D-loop; other site 262316001052 H-loop/switch region; other site 262316001053 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316001054 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 262316001055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316001056 motif II; other site 262316001057 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 262316001058 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 262316001059 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 262316001060 hexamer interface [polypeptide binding]; other site 262316001061 Walker B motif; other site 262316001062 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 262316001063 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 262316001064 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 262316001065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316001066 ATP binding site [chemical binding]; other site 262316001067 putative Mg++ binding site [ion binding]; other site 262316001068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316001069 nucleotide binding region [chemical binding]; other site 262316001070 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 262316001071 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262316001072 DNA-binding site [nucleotide binding]; DNA binding site 262316001073 RNA-binding motif; other site 262316001074 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 262316001075 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 262316001076 active site 262316001077 interdomain interaction site; other site 262316001078 putative metal-binding site [ion binding]; other site 262316001079 nucleotide binding site [chemical binding]; other site 262316001080 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 262316001081 domain I; other site 262316001082 phosphate binding site [ion binding]; other site 262316001083 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 262316001084 domain II; other site 262316001085 domain III; other site 262316001086 nucleotide binding site [chemical binding]; other site 262316001087 DNA binding groove [nucleotide binding] 262316001088 catalytic site [active] 262316001089 domain IV; other site 262316001090 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 262316001091 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 262316001092 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 262316001093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316001094 dimerization interface [polypeptide binding]; other site 262316001095 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316001096 cyclase homology domain; Region: CHD; cd07302 262316001097 nucleotidyl binding site; other site 262316001098 metal binding site [ion binding]; metal-binding site 262316001099 dimer interface [polypeptide binding]; other site 262316001100 DNA polymerase III subunit delta'; Validated; Region: PRK07940 262316001101 DNA polymerase III subunit delta'; Validated; Region: PRK08485 262316001102 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 262316001103 Helix-turn-helix domain; Region: HTH_28; pfam13518 262316001104 Winged helix-turn helix; Region: HTH_29; pfam13551 262316001105 Homeodomain-like domain; Region: HTH_32; pfam13565 262316001106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316001107 Integrase core domain; Region: rve; pfam00665 262316001108 Integrase core domain; Region: rve_3; pfam13683 262316001109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316001110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001111 NAD(P) binding site [chemical binding]; other site 262316001112 active site 262316001113 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 262316001114 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 262316001115 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 262316001116 Ligand binding site; other site 262316001117 Putative Catalytic site; other site 262316001118 DXD motif; other site 262316001119 Protein of unknown function (DUF475); Region: DUF475; pfam04332 262316001120 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 262316001121 dimer interface [polypeptide binding]; other site 262316001122 substrate binding site [chemical binding]; other site 262316001123 metal binding sites [ion binding]; metal-binding site 262316001124 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 262316001125 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 262316001126 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 262316001127 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 262316001128 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 262316001129 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 262316001130 Ligand Binding Site [chemical binding]; other site 262316001131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316001132 active site 262316001133 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 262316001134 PE family; Region: PE; pfam00934 262316001135 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316001136 PPE family; Region: PPE; pfam00823 262316001137 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316001138 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316001139 active site 262316001140 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316001141 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 262316001142 putative NAD(P) binding site [chemical binding]; other site 262316001143 catalytic Zn binding site [ion binding]; other site 262316001144 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001145 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316001146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316001147 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316001148 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 262316001149 dimer interface [polypeptide binding]; other site 262316001150 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316001151 metal binding site [ion binding]; metal-binding site 262316001152 FtsH Extracellular; Region: FtsH_ext; pfam06480 262316001153 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 262316001154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316001155 Walker A motif; other site 262316001156 ATP binding site [chemical binding]; other site 262316001157 Walker B motif; other site 262316001158 arginine finger; other site 262316001159 Peptidase family M41; Region: Peptidase_M41; pfam01434 262316001160 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 262316001161 homodecamer interface [polypeptide binding]; other site 262316001162 GTP cyclohydrolase I; Provisional; Region: PLN03044 262316001163 active site 262316001164 putative catalytic site residues [active] 262316001165 zinc binding site [ion binding]; other site 262316001166 GTP-CH-I/GFRP interaction surface; other site 262316001167 dihydropteroate synthase; Region: DHPS; TIGR01496 262316001168 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 262316001169 substrate binding pocket [chemical binding]; other site 262316001170 dimer interface [polypeptide binding]; other site 262316001171 inhibitor binding site; inhibition site 262316001172 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 262316001173 homooctamer interface [polypeptide binding]; other site 262316001174 active site 262316001175 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 262316001176 catalytic center binding site [active] 262316001177 ATP binding site [chemical binding]; other site 262316001178 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 262316001179 Rossmann-like domain; Region: Rossmann-like; pfam10727 262316001180 Uncharacterized conserved protein [Function unknown]; Region: COG5495 262316001181 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 262316001182 Pantoate-beta-alanine ligase; Region: PanC; cd00560 262316001183 pantoate--beta-alanine ligase; Region: panC; TIGR00018 262316001184 active site 262316001185 ATP-binding site [chemical binding]; other site 262316001186 pantoate-binding site; other site 262316001187 HXXH motif; other site 262316001188 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 262316001189 tetramerization interface [polypeptide binding]; other site 262316001190 active site 262316001191 pantothenate kinase; Reviewed; Region: PRK13318 262316001192 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 262316001193 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 262316001194 dimer interface [polypeptide binding]; other site 262316001195 putative anticodon binding site; other site 262316001196 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316001197 motif 1; other site 262316001198 dimer interface [polypeptide binding]; other site 262316001199 active site 262316001200 motif 2; other site 262316001201 motif 3; other site 262316001202 Lsr2; Region: Lsr2; pfam11774 262316001203 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 262316001204 Clp amino terminal domain; Region: Clp_N; pfam02861 262316001205 Clp amino terminal domain; Region: Clp_N; pfam02861 262316001206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316001207 Walker A motif; other site 262316001208 ATP binding site [chemical binding]; other site 262316001209 Walker B motif; other site 262316001210 arginine finger; other site 262316001211 UvrB/uvrC motif; Region: UVR; pfam02151 262316001212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316001213 Walker A motif; other site 262316001214 ATP binding site [chemical binding]; other site 262316001215 Walker B motif; other site 262316001216 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 262316001217 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 262316001218 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316001219 catalytic core [active] 262316001220 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 262316001221 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 262316001222 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 262316001223 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 262316001224 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 262316001225 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001226 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 262316001227 catalytic site [active] 262316001228 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 262316001229 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316001230 minor groove reading motif; other site 262316001231 helix-hairpin-helix signature motif; other site 262316001232 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 262316001233 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 262316001234 active site clefts [active] 262316001235 zinc binding site [ion binding]; other site 262316001236 dimer interface [polypeptide binding]; other site 262316001237 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 262316001238 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 262316001239 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 262316001240 DNA repair protein RadA; Provisional; Region: PRK11823 262316001241 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 262316001242 Walker A motif; other site 262316001243 ATP binding site [chemical binding]; other site 262316001244 Walker B motif; other site 262316001245 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 262316001246 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 262316001247 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 262316001248 substrate binding site; other site 262316001249 dimer interface; other site 262316001250 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 262316001251 homotrimer interaction site [polypeptide binding]; other site 262316001252 zinc binding site [ion binding]; other site 262316001253 CDP-binding sites; other site 262316001254 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 262316001255 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316001256 active site 262316001257 HIGH motif; other site 262316001258 nucleotide binding site [chemical binding]; other site 262316001259 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 262316001260 KMSKS motif; other site 262316001261 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262316001262 tRNA binding surface [nucleotide binding]; other site 262316001263 anticodon binding site; other site 262316001264 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262316001265 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 262316001266 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262316001267 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 262316001268 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 262316001269 active site 262316001270 catalytic site [active] 262316001271 metal binding site [ion binding]; metal-binding site 262316001272 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 262316001273 Predicted ATPase [General function prediction only]; Region: COG3899 262316001274 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316001275 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316001276 DNA binding residues [nucleotide binding] 262316001277 dimerization interface [polypeptide binding]; other site 262316001278 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 262316001279 transmembrane helices; other site 262316001280 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 262316001281 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 262316001282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316001283 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 262316001284 putative active site [active] 262316001285 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 262316001286 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 262316001287 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 262316001288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316001289 Walker A/P-loop; other site 262316001290 ATP binding site [chemical binding]; other site 262316001291 Q-loop/lid; other site 262316001292 ABC transporter signature motif; other site 262316001293 Walker B; other site 262316001294 D-loop; other site 262316001295 H-loop/switch region; other site 262316001296 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 262316001297 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 262316001298 intersubunit interface [polypeptide binding]; other site 262316001299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262316001300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262316001301 DNA binding site [nucleotide binding] 262316001302 domain linker motif; other site 262316001303 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 262316001304 putative dimerization interface [polypeptide binding]; other site 262316001305 putative ligand binding site [chemical binding]; other site 262316001306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001308 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001309 active site 262316001310 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001311 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001312 active site 262316001313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001314 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 262316001315 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316001316 putative NAD(P) binding site [chemical binding]; other site 262316001317 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 262316001318 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 262316001319 FAD binding pocket [chemical binding]; other site 262316001320 FAD binding motif [chemical binding]; other site 262316001321 phosphate binding motif [ion binding]; other site 262316001322 beta-alpha-beta structure motif; other site 262316001323 NAD(p) ribose binding residues [chemical binding]; other site 262316001324 NAD binding pocket [chemical binding]; other site 262316001325 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 262316001326 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316001327 catalytic loop [active] 262316001328 iron binding site [ion binding]; other site 262316001329 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001330 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 262316001331 Flavin binding site [chemical binding]; other site 262316001332 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 262316001333 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 262316001334 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 262316001335 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 262316001336 active site 262316001337 Fe binding site [ion binding]; other site 262316001338 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 262316001339 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 262316001340 aspartate aminotransferase; Provisional; Region: PRK05764 262316001341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316001342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316001343 homodimer interface [polypeptide binding]; other site 262316001344 catalytic residue [active] 262316001345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001346 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001348 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001350 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001351 active site 262316001352 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001353 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001354 active site 262316001355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316001356 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316001357 acyl-activating enzyme (AAE) consensus motif; other site 262316001358 acyl-activating enzyme (AAE) consensus motif; other site 262316001359 active site 262316001360 AMP binding site [chemical binding]; other site 262316001361 CoA binding site [chemical binding]; other site 262316001362 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001364 active site 262316001365 short chain dehydrogenase; Provisional; Region: PRK07831 262316001366 classical (c) SDRs; Region: SDR_c; cd05233 262316001367 NAD(P) binding site [chemical binding]; other site 262316001368 active site 262316001369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001371 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 262316001372 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316001373 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001374 dimer interface [polypeptide binding]; other site 262316001375 active site 262316001376 Nitronate monooxygenase; Region: NMO; pfam03060 262316001377 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262316001378 FMN binding site [chemical binding]; other site 262316001379 substrate binding site [chemical binding]; other site 262316001380 putative catalytic residue [active] 262316001381 Coenzyme A transferase; Region: CoA_trans; cl17247 262316001382 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 262316001383 enoyl-CoA hydratase; Provisional; Region: PRK06495 262316001384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316001385 substrate binding site [chemical binding]; other site 262316001386 oxyanion hole (OAH) forming residues; other site 262316001387 trimer interface [polypeptide binding]; other site 262316001388 short chain dehydrogenase; Provisional; Region: PRK07856 262316001389 classical (c) SDRs; Region: SDR_c; cd05233 262316001390 NAD(P) binding site [chemical binding]; other site 262316001391 active site 262316001392 short chain dehydrogenase; Provisional; Region: PRK07791 262316001393 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 262316001394 homodimer interface [polypeptide binding]; other site 262316001395 NAD binding site [chemical binding]; other site 262316001396 active site 262316001397 Domain of unknown function (DUF385); Region: DUF385; pfam04075 262316001398 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 262316001399 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001400 dimer interface [polypeptide binding]; other site 262316001401 active site 262316001402 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001403 Cytochrome P450; Region: p450; cl12078 262316001404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001405 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001406 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001407 active site 262316001408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001410 active site 262316001411 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316001412 active site 262316001413 catalytic site [active] 262316001414 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316001415 active site 2 [active] 262316001416 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316001417 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001418 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316001419 putative active site [active] 262316001420 putative catalytic site [active] 262316001421 lipid-transfer protein; Provisional; Region: PRK07855 262316001422 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316001423 active site 262316001424 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 262316001425 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316001426 putative active site [active] 262316001427 enoyl-CoA hydratase; Region: PLN02864 262316001428 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 262316001429 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 262316001430 dimer interaction site [polypeptide binding]; other site 262316001431 substrate-binding tunnel; other site 262316001432 active site 262316001433 catalytic site [active] 262316001434 substrate binding site [chemical binding]; other site 262316001435 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 262316001436 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262316001437 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 262316001438 acetaldehyde dehydrogenase; Validated; Region: PRK08300 262316001439 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 262316001440 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 262316001441 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 262316001442 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 262316001443 active site 262316001444 catalytic residues [active] 262316001445 metal binding site [ion binding]; metal-binding site 262316001446 DmpG-like communication domain; Region: DmpG_comm; pfam07836 262316001447 short chain dehydrogenase; Provisional; Region: PRK07890 262316001448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001449 NAD(P) binding site [chemical binding]; other site 262316001450 active site 262316001451 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 262316001452 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 262316001453 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 262316001454 trimer interface [polypeptide binding]; other site 262316001455 putative metal binding site [ion binding]; other site 262316001456 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316001457 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 262316001458 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316001459 active site 262316001460 lipid-transfer protein; Provisional; Region: PRK07937 262316001461 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316001462 active site 262316001463 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316001464 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001465 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316001466 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001467 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316001468 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 262316001469 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 262316001470 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001471 Cytochrome P450; Region: p450; cl12078 262316001472 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316001473 putative active site [active] 262316001474 enoyl-CoA hydratase; Provisional; Region: PRK07799 262316001475 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316001476 substrate binding site [chemical binding]; other site 262316001477 oxyanion hole (OAH) forming residues; other site 262316001478 trimer interface [polypeptide binding]; other site 262316001479 acyl-CoA synthetase; Validated; Region: PRK07798 262316001480 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316001481 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 262316001482 acyl-activating enzyme (AAE) consensus motif; other site 262316001483 acyl-activating enzyme (AAE) consensus motif; other site 262316001484 putative AMP binding site [chemical binding]; other site 262316001485 putative active site [active] 262316001486 putative CoA binding site [chemical binding]; other site 262316001487 Fructosamine kinase; Region: Fructosamin_kin; cl17579 262316001488 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 262316001489 hypothetical protein; Validated; Region: PRK07586 262316001490 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316001491 PYR/PP interface [polypeptide binding]; other site 262316001492 dimer interface [polypeptide binding]; other site 262316001493 TPP binding site [chemical binding]; other site 262316001494 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 262316001495 TPP-binding site [chemical binding]; other site 262316001496 acyl-CoA synthetase; Validated; Region: PRK07867 262316001497 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 262316001498 acyl-activating enzyme (AAE) consensus motif; other site 262316001499 putative AMP binding site [chemical binding]; other site 262316001500 putative active site [active] 262316001501 putative CoA binding site [chemical binding]; other site 262316001502 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001503 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316001504 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001505 active site 262316001506 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001507 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 262316001508 FAD binding site [chemical binding]; other site 262316001509 substrate binding site [chemical binding]; other site 262316001510 catalytic base [active] 262316001511 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316001512 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316001513 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 262316001514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001515 NAD(P) binding site [chemical binding]; other site 262316001516 active site 262316001517 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316001518 Permease; Region: Permease; pfam02405 262316001519 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316001520 Permease; Region: Permease; pfam02405 262316001521 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001522 mce related protein; Region: MCE; pfam02470 262316001523 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316001524 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001525 mce related protein; Region: MCE; pfam02470 262316001526 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316001527 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001528 mce related protein; Region: MCE; pfam02470 262316001529 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 262316001530 mce related protein; Region: MCE; pfam02470 262316001531 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001532 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001533 mce related protein; Region: MCE; pfam02470 262316001534 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316001535 mce related protein; Region: MCE; pfam02470 262316001536 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 262316001537 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 262316001538 active site 262316001539 homotetramer interface [polypeptide binding]; other site 262316001540 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 262316001541 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 262316001542 Walker A/P-loop; other site 262316001543 ATP binding site [chemical binding]; other site 262316001544 Q-loop/lid; other site 262316001545 ABC transporter signature motif; other site 262316001546 Walker B; other site 262316001547 D-loop; other site 262316001548 H-loop/switch region; other site 262316001549 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 262316001550 enoyl-CoA hydratase; Provisional; Region: PRK08290 262316001551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316001552 substrate binding site [chemical binding]; other site 262316001553 oxyanion hole (OAH) forming residues; other site 262316001554 trimer interface [polypeptide binding]; other site 262316001555 short chain dehydrogenase; Provisional; Region: PRK05875 262316001556 classical (c) SDRs; Region: SDR_c; cd05233 262316001557 NAD(P) binding site [chemical binding]; other site 262316001558 active site 262316001559 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316001560 classical (c) SDRs; Region: SDR_c; cd05233 262316001561 NAD(P) binding site [chemical binding]; other site 262316001562 active site 262316001563 Transcriptional regulator [Transcription]; Region: LytR; COG1316 262316001564 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 262316001565 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 262316001566 Amidase; Region: Amidase; pfam01425 262316001567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001568 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 262316001569 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316001570 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 262316001571 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262316001572 catalytic residue [active] 262316001573 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316001574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 262316001575 binding surface 262316001576 TPR motif; other site 262316001577 Helix-turn-helix domain; Region: HTH_28; pfam13518 262316001578 Winged helix-turn helix; Region: HTH_29; pfam13551 262316001579 Homeodomain-like domain; Region: HTH_32; pfam13565 262316001580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316001581 Integrase core domain; Region: rve; pfam00665 262316001582 Integrase core domain; Region: rve_3; pfam13683 262316001583 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316001584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316001585 active site 262316001586 phosphorylation site [posttranslational modification] 262316001587 intermolecular recognition site; other site 262316001588 dimerization interface [polypeptide binding]; other site 262316001589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316001590 DNA binding site [nucleotide binding] 262316001591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316001592 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316001593 dimerization interface [polypeptide binding]; other site 262316001594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316001595 dimer interface [polypeptide binding]; other site 262316001596 phosphorylation site [posttranslational modification] 262316001597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316001598 ATP binding site [chemical binding]; other site 262316001599 Mg2+ binding site [ion binding]; other site 262316001600 G-X-G motif; other site 262316001601 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 262316001602 nucleotide binding site/active site [active] 262316001603 HIT family signature motif; other site 262316001604 catalytic residue [active] 262316001605 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 262316001606 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 262316001607 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316001608 NAD binding site [chemical binding]; other site 262316001609 catalytic Zn binding site [ion binding]; other site 262316001610 substrate binding site [chemical binding]; other site 262316001611 structural Zn binding site [ion binding]; other site 262316001612 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316001613 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 262316001614 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001615 Cytochrome P450; Region: p450; cl12078 262316001616 short chain dehydrogenase; Provisional; Region: PRK07775 262316001617 classical (c) SDRs; Region: SDR_c; cd05233 262316001618 NAD(P) binding site [chemical binding]; other site 262316001619 active site 262316001620 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001621 Cytochrome P450; Region: p450; cl12078 262316001622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001623 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 262316001624 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 262316001625 NAD binding site [chemical binding]; other site 262316001626 catalytic residues [active] 262316001627 short chain dehydrogenase; Provisional; Region: PRK07774 262316001628 classical (c) SDRs; Region: SDR_c; cd05233 262316001629 NAD(P) binding site [chemical binding]; other site 262316001630 active site 262316001631 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 262316001632 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262316001633 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 262316001634 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 262316001635 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 262316001636 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 262316001637 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 262316001638 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 262316001639 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 262316001640 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 262316001641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 262316001642 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 262316001643 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 262316001644 adenylosuccinate lyase; Region: purB; TIGR00928 262316001645 tetramer interface [polypeptide binding]; other site 262316001646 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001647 Cytochrome P450; Region: p450; cl12078 262316001648 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 262316001649 ATP binding site [chemical binding]; other site 262316001650 active site 262316001651 substrate binding site [chemical binding]; other site 262316001652 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 262316001653 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316001654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001656 WHG domain; Region: WHG; pfam13305 262316001657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316001658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316001659 putative substrate translocation pore; other site 262316001660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316001661 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 262316001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316001663 putative substrate translocation pore; other site 262316001664 Predicted deacetylase [General function prediction only]; Region: COG3233 262316001665 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 262316001666 putative active site [active] 262316001667 putative Zn binding site [ion binding]; other site 262316001668 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262316001669 FAD binding domain; Region: FAD_binding_2; pfam00890 262316001670 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 262316001671 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316001672 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 262316001673 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 262316001674 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 262316001675 putative active site [active] 262316001676 catalytic triad [active] 262316001677 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262316001678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316001679 DNA-binding site [nucleotide binding]; DNA binding site 262316001680 UTRA domain; Region: UTRA; pfam07702 262316001681 Cupin domain; Region: Cupin_2; cl17218 262316001682 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 262316001683 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 262316001684 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 262316001685 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 262316001686 active site 262316001687 metal binding site [ion binding]; metal-binding site 262316001688 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316001689 active site 262316001690 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316001691 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 262316001692 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 262316001693 dimerization interface [polypeptide binding]; other site 262316001694 ATP binding site [chemical binding]; other site 262316001695 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 262316001696 dimerization interface [polypeptide binding]; other site 262316001697 ATP binding site [chemical binding]; other site 262316001698 CAAX protease self-immunity; Region: Abi; pfam02517 262316001699 amidophosphoribosyltransferase; Provisional; Region: PRK07847 262316001700 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 262316001701 active site 262316001702 tetramer interface [polypeptide binding]; other site 262316001703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316001704 active site 262316001705 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 262316001706 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 262316001707 dimerization interface [polypeptide binding]; other site 262316001708 putative ATP binding site [chemical binding]; other site 262316001709 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 262316001710 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 262316001711 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 262316001712 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 262316001713 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 262316001714 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 262316001715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316001716 catalytic residue [active] 262316001717 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 262316001718 heme-binding site [chemical binding]; other site 262316001719 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 262316001720 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 262316001721 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 262316001722 active site residue [active] 262316001723 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 262316001724 active site residue [active] 262316001725 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 262316001726 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262316001727 catalytic residues [active] 262316001728 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 262316001729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316001730 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316001731 DNA binding site [nucleotide binding] 262316001732 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 262316001733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316001734 Coenzyme A binding pocket [chemical binding]; other site 262316001735 PBP superfamily domain; Region: PBP_like_2; cl17296 262316001736 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 262316001737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316001738 dimer interface [polypeptide binding]; other site 262316001739 conserved gate region; other site 262316001740 putative PBP binding loops; other site 262316001741 ABC-ATPase subunit interface; other site 262316001742 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 262316001743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316001744 dimer interface [polypeptide binding]; other site 262316001745 conserved gate region; other site 262316001746 putative PBP binding loops; other site 262316001747 ABC-ATPase subunit interface; other site 262316001748 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 262316001749 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 262316001750 Walker A/P-loop; other site 262316001751 ATP binding site [chemical binding]; other site 262316001752 Q-loop/lid; other site 262316001753 ABC transporter signature motif; other site 262316001754 Walker B; other site 262316001755 D-loop; other site 262316001756 H-loop/switch region; other site 262316001757 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 262316001758 PhoU domain; Region: PhoU; pfam01895 262316001759 PhoU domain; Region: PhoU; pfam01895 262316001760 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 262316001761 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 262316001762 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 262316001763 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 262316001764 FMN binding site [chemical binding]; other site 262316001765 active site 262316001766 catalytic residues [active] 262316001767 substrate binding site [chemical binding]; other site 262316001768 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 262316001769 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 262316001770 homodimer interface [polypeptide binding]; other site 262316001771 putative substrate binding pocket [chemical binding]; other site 262316001772 diiron center [ion binding]; other site 262316001773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 262316001775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316001776 dimerization interface [polypeptide binding]; other site 262316001777 putative DNA binding site [nucleotide binding]; other site 262316001778 putative Zn2+ binding site [ion binding]; other site 262316001779 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 262316001780 nucleoside/Zn binding site; other site 262316001781 dimer interface [polypeptide binding]; other site 262316001782 catalytic motif [active] 262316001783 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316001784 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316001785 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 262316001786 Winged helix-turn helix; Region: HTH_29; pfam13551 262316001787 DNA-binding interface [nucleotide binding]; DNA binding site 262316001788 Homeodomain-like domain; Region: HTH_32; pfam13565 262316001789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316001790 Integrase core domain; Region: rve; pfam00665 262316001791 Integrase core domain; Region: rve_3; pfam13683 262316001792 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316001793 classical (c) SDRs; Region: SDR_c; cd05233 262316001794 NAD(P) binding site [chemical binding]; other site 262316001795 active site 262316001796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001798 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316001799 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316001800 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001801 Cytochrome P450; Region: p450; cl12078 262316001802 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262316001803 DNA-binding site [nucleotide binding]; DNA binding site 262316001804 RNA-binding motif; other site 262316001805 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 262316001806 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262316001807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316001808 S-adenosylmethionine binding site [chemical binding]; other site 262316001809 short chain dehydrogenase; Provisional; Region: PRK08278 262316001810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001811 NAD(P) binding site [chemical binding]; other site 262316001812 active site 262316001813 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 262316001814 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 262316001815 B12 binding site [chemical binding]; other site 262316001816 cobalt ligand [ion binding]; other site 262316001817 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316001818 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001819 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316001820 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316001821 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316001822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316001823 catalytic loop [active] 262316001824 iron binding site [ion binding]; other site 262316001825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 262316001826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316001827 acyl-activating enzyme (AAE) consensus motif; other site 262316001828 AMP binding site [chemical binding]; other site 262316001829 active site 262316001830 CoA binding site [chemical binding]; other site 262316001831 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001833 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001835 active site 262316001836 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316001837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316001838 substrate binding site [chemical binding]; other site 262316001839 oxyanion hole (OAH) forming residues; other site 262316001840 trimer interface [polypeptide binding]; other site 262316001841 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 262316001842 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 262316001843 putative acyltransferase; Provisional; Region: PRK05790 262316001844 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001845 dimer interface [polypeptide binding]; other site 262316001846 active site 262316001847 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 262316001848 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262316001849 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 262316001850 G4 box; other site 262316001851 G5 box; other site 262316001852 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 262316001853 TPP-binding site [chemical binding]; other site 262316001854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316001855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316001856 active site 262316001857 phosphorylation site [posttranslational modification] 262316001858 intermolecular recognition site; other site 262316001859 dimerization interface [polypeptide binding]; other site 262316001860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316001861 DNA binding residues [nucleotide binding] 262316001862 dimerization interface [polypeptide binding]; other site 262316001863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 262316001864 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 262316001865 ATP binding site [chemical binding]; other site 262316001866 Mg2+ binding site [ion binding]; other site 262316001867 G-X-G motif; other site 262316001868 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 262316001869 Predicted oxidoreductase [General function prediction only]; Region: COG3573 262316001870 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316001871 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 262316001872 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316001873 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316001874 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 262316001875 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316001876 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 262316001877 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 262316001878 putative active site [active] 262316001879 Fe(II) binding site [ion binding]; other site 262316001880 putative dimer interface [polypeptide binding]; other site 262316001881 putative tetramer interface [polypeptide binding]; other site 262316001882 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 262316001883 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262316001884 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316001885 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 262316001886 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316001887 NAD(P) binding site [chemical binding]; other site 262316001888 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 262316001889 active site 262316001890 Putative cyclase; Region: Cyclase; pfam04199 262316001891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316001892 TAP-like protein; Region: Abhydrolase_4; pfam08386 262316001893 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 262316001894 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 262316001895 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 262316001896 Multicopper oxidase; Region: Cu-oxidase; pfam00394 262316001897 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 262316001898 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 262316001899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001900 NAD(P) binding site [chemical binding]; other site 262316001901 active site 262316001902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001904 Cytochrome P450; Region: p450; cl12078 262316001905 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001906 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316001907 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316001908 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316001909 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 262316001910 active site 262316001911 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316001912 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316001913 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 262316001914 active site 262316001915 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316001916 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316001917 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316001918 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316001919 classical (c) SDRs; Region: SDR_c; cd05233 262316001920 NAD(P) binding site [chemical binding]; other site 262316001921 active site 262316001922 short chain dehydrogenase; Provisional; Region: PRK05876 262316001923 classical (c) SDRs; Region: SDR_c; cd05233 262316001924 NAD(P) binding site [chemical binding]; other site 262316001925 active site 262316001926 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316001927 classical (c) SDRs; Region: SDR_c; cd05233 262316001928 NAD(P) binding site [chemical binding]; other site 262316001929 active site 262316001930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316001931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001932 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001933 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001934 active site 262316001935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001937 active site 262316001938 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001939 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001940 active site 262316001941 SnoaL-like domain; Region: SnoaL_4; pfam13577 262316001942 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 262316001943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316001944 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 262316001945 active site 262316001946 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316001947 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316001948 [2Fe-2S] cluster binding site [ion binding]; other site 262316001949 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 262316001950 alpha subunit interface [polypeptide binding]; other site 262316001951 active site 262316001952 substrate binding site [chemical binding]; other site 262316001953 Fe binding site [ion binding]; other site 262316001954 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316001955 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316001956 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316001957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316001958 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316001959 active site 262316001960 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316001961 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316001962 dimer interface [polypeptide binding]; other site 262316001963 active site 262316001964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316001965 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001966 Cytochrome P450; Region: p450; cl12078 262316001967 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 262316001968 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316001969 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 262316001970 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316001971 Cytochrome P450; Region: p450; cl12078 262316001972 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262316001973 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 262316001974 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316001975 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316001976 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316001977 lipid-transfer protein; Provisional; Region: PRK07855 262316001978 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316001979 active site 262316001980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316001981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316001982 NAD(P) binding site [chemical binding]; other site 262316001983 active site 262316001984 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316001985 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316001986 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316001987 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 262316001988 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316001989 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 262316001990 iron-sulfur cluster [ion binding]; other site 262316001991 [2Fe-2S] cluster binding site [ion binding]; other site 262316001992 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316001993 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316001994 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 262316001995 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262316001996 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316001997 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 262316001998 FMN binding site [chemical binding]; other site 262316001999 dimer interface [polypeptide binding]; other site 262316002000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316002001 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316002002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002003 active site 262316002004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316002005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002006 active site 262316002007 Predicted esterase [General function prediction only]; Region: COG0627 262316002008 Cytochrome P450; Region: p450; cl12078 262316002009 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316002010 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 262316002011 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316002012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002013 NAD(P) binding site [chemical binding]; other site 262316002014 active site 262316002015 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 262316002016 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 262316002017 NAD binding site [chemical binding]; other site 262316002018 catalytic residues [active] 262316002019 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316002020 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316002021 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316002022 Permease; Region: Permease; pfam02405 262316002023 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316002024 Permease; Region: Permease; pfam02405 262316002025 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 262316002026 mce related protein; Region: MCE; pfam02470 262316002027 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316002028 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316002029 mce related protein; Region: MCE; pfam02470 262316002030 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316002031 mce related protein; Region: MCE; pfam02470 262316002032 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316002033 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316002034 mce related protein; Region: MCE; pfam02470 262316002035 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316002036 mce related protein; Region: MCE; pfam02470 262316002037 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316002038 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316002039 mce related protein; Region: MCE; pfam02470 262316002040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002042 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 262316002043 Subunit I/III interface [polypeptide binding]; other site 262316002044 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316002045 Cytochrome P450; Region: p450; cl12078 262316002046 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002047 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002048 enoyl-CoA hydratase; Provisional; Region: PRK06688 262316002049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316002050 substrate binding site [chemical binding]; other site 262316002051 oxyanion hole (OAH) forming residues; other site 262316002052 trimer interface [polypeptide binding]; other site 262316002053 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316002054 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316002055 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 262316002056 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316002057 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 262316002058 acyl-activating enzyme (AAE) consensus motif; other site 262316002059 acyl-activating enzyme (AAE) consensus motif; other site 262316002060 putative AMP binding site [chemical binding]; other site 262316002061 putative active site [active] 262316002062 putative CoA binding site [chemical binding]; other site 262316002063 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 262316002064 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 262316002065 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 262316002066 dimer interface [polypeptide binding]; other site 262316002067 PYR/PP interface [polypeptide binding]; other site 262316002068 TPP binding site [chemical binding]; other site 262316002069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316002070 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 262316002071 TPP-binding site [chemical binding]; other site 262316002072 dimer interface [polypeptide binding]; other site 262316002073 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316002074 putative hydrophobic ligand binding site [chemical binding]; other site 262316002075 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316002076 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316002077 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316002078 putative hydrophobic ligand binding site [chemical binding]; other site 262316002079 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316002080 putative hydrophobic ligand binding site [chemical binding]; other site 262316002081 aminotransferase; Validated; Region: PRK07777 262316002082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316002084 homodimer interface [polypeptide binding]; other site 262316002085 catalytic residue [active] 262316002086 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 262316002087 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316002088 dimer interface [polypeptide binding]; other site 262316002089 active site 262316002090 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 262316002091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316002092 substrate binding site [chemical binding]; other site 262316002093 oxyanion hole (OAH) forming residues; other site 262316002094 trimer interface [polypeptide binding]; other site 262316002095 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316002096 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262316002097 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 262316002098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316002099 S-adenosylmethionine binding site [chemical binding]; other site 262316002100 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 262316002101 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316002102 hypothetical protein; Provisional; Region: PRK07236 262316002103 hypothetical protein; Provisional; Region: PRK07588 262316002104 hypothetical protein; Provisional; Region: PRK07236 262316002105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002107 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316002108 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002109 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 262316002110 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316002111 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316002112 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 262316002113 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316002114 active site 262316002115 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 262316002116 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 262316002117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316002118 ATP binding site [chemical binding]; other site 262316002119 putative Mg++ binding site [ion binding]; other site 262316002120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316002121 nucleotide binding region [chemical binding]; other site 262316002122 ATP-binding site [chemical binding]; other site 262316002123 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 262316002124 WYL domain; Region: WYL; pfam13280 262316002125 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 262316002126 trimer interface [polypeptide binding]; other site 262316002127 dimer interface [polypeptide binding]; other site 262316002128 putative active site [active] 262316002129 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 262316002130 MPT binding site; other site 262316002131 trimer interface [polypeptide binding]; other site 262316002132 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 262316002133 MoaE homodimer interface [polypeptide binding]; other site 262316002134 MoaD interaction [polypeptide binding]; other site 262316002135 active site residues [active] 262316002136 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 262316002137 Ubiquitin-like proteins; Region: UBQ; cl00155 262316002138 charged pocket; other site 262316002139 hydrophobic patch; other site 262316002140 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 262316002141 hypothetical protein; Provisional; Region: PRK11770 262316002142 Domain of unknown function (DUF307); Region: DUF307; pfam03733 262316002143 Domain of unknown function (DUF307); Region: DUF307; pfam03733 262316002144 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 262316002145 DNA-binding site [nucleotide binding]; DNA binding site 262316002146 RNA-binding motif; other site 262316002147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002148 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316002149 active site 262316002150 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 262316002151 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 262316002152 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 262316002153 putative dimer interface [polypeptide binding]; other site 262316002154 N-terminal domain interface [polypeptide binding]; other site 262316002155 putative substrate binding pocket (H-site) [chemical binding]; other site 262316002156 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316002157 putative active site [active] 262316002158 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 262316002159 H+ Antiporter protein; Region: 2A0121; TIGR00900 262316002160 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 262316002161 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316002162 hydrophobic ligand binding site; other site 262316002163 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 262316002164 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316002165 MarR family; Region: MarR; pfam01047 262316002166 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262316002167 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262316002168 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 262316002169 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 262316002170 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316002171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316002172 catalytic residue [active] 262316002173 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 262316002174 Ferredoxin [Energy production and conversion]; Region: COG1146 262316002175 4Fe-4S binding domain; Region: Fer4; pfam00037 262316002176 ferredoxin-NADP+ reductase; Region: PLN02852 262316002177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316002178 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 262316002179 putative dimer interface [polypeptide binding]; other site 262316002180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316002181 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 262316002182 dimer interface [polypeptide binding]; other site 262316002183 Citrate synthase; Region: Citrate_synt; pfam00285 262316002184 active site 262316002185 citrylCoA binding site [chemical binding]; other site 262316002186 oxalacetate/citrate binding site [chemical binding]; other site 262316002187 coenzyme A binding site [chemical binding]; other site 262316002188 catalytic triad [active] 262316002189 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 262316002190 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 262316002191 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 262316002192 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 262316002193 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 262316002194 dimer interface [polypeptide binding]; other site 262316002195 active site 262316002196 citrylCoA binding site [chemical binding]; other site 262316002197 NADH binding [chemical binding]; other site 262316002198 cationic pore residues; other site 262316002199 oxalacetate/citrate binding site [chemical binding]; other site 262316002200 coenzyme A binding site [chemical binding]; other site 262316002201 catalytic triad [active] 262316002202 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316002203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316002204 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 262316002205 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316002206 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316002207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316002208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316002209 dimer interface [polypeptide binding]; other site 262316002210 phosphorylation site [posttranslational modification] 262316002211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002212 Mg2+ binding site [ion binding]; other site 262316002213 G-X-G motif; other site 262316002214 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316002215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316002216 active site 262316002217 phosphorylation site [posttranslational modification] 262316002218 intermolecular recognition site; other site 262316002219 dimerization interface [polypeptide binding]; other site 262316002220 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316002221 DNA binding site [nucleotide binding] 262316002222 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 262316002223 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 262316002224 putative ADP-binding pocket [chemical binding]; other site 262316002225 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 262316002226 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 262316002227 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316002228 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 262316002229 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262316002230 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316002231 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316002232 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316002233 substrate binding site [chemical binding]; other site 262316002234 oxyanion hole (OAH) forming residues; other site 262316002235 trimer interface [polypeptide binding]; other site 262316002236 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 262316002237 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 262316002238 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316002239 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316002240 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 262316002241 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316002242 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 262316002243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316002244 motif II; other site 262316002245 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 262316002246 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316002247 hydrophobic ligand binding site; other site 262316002248 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 262316002249 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316002250 MULE transposase domain; Region: MULE; pfam10551 262316002251 Helix-turn-helix domain; Region: HTH_28; pfam13518 262316002252 Winged helix-turn helix; Region: HTH_29; pfam13551 262316002253 Homeodomain-like domain; Region: HTH_32; pfam13565 262316002254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316002255 Integrase core domain; Region: rve; pfam00665 262316002256 Integrase core domain; Region: rve_3; pfam13683 262316002257 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 262316002258 KaiC; Region: KaiC; pfam06745 262316002259 Walker A motif; other site 262316002260 ATP binding site [chemical binding]; other site 262316002261 Walker B motif; other site 262316002262 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 262316002263 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 262316002264 putative active site [active] 262316002265 putative metal binding site [ion binding]; other site 262316002266 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 262316002267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316002268 active site 262316002269 DNA binding site [nucleotide binding] 262316002270 Int/Topo IB signature motif; other site 262316002271 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 262316002272 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002273 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 262316002274 putative active site pocket [active] 262316002275 dimerization interface [polypeptide binding]; other site 262316002276 putative catalytic residue [active] 262316002277 Protein of unknown function (DUF867); Region: DUF867; pfam05908 262316002278 manganese transport protein MntH; Reviewed; Region: PRK00701 262316002279 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 262316002280 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316002281 short chain dehydrogenase; Provisional; Region: PRK07814 262316002282 classical (c) SDRs; Region: SDR_c; cd05233 262316002283 NAD(P) binding site [chemical binding]; other site 262316002284 active site 262316002285 PBP superfamily domain; Region: PBP_like_2; cl17296 262316002286 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 262316002287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316002288 dimer interface [polypeptide binding]; other site 262316002289 conserved gate region; other site 262316002290 putative PBP binding loops; other site 262316002291 ABC-ATPase subunit interface; other site 262316002292 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 262316002293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316002294 dimer interface [polypeptide binding]; other site 262316002295 conserved gate region; other site 262316002296 putative PBP binding loops; other site 262316002297 ABC-ATPase subunit interface; other site 262316002298 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 262316002299 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 262316002300 putative DNA binding site [nucleotide binding]; other site 262316002301 putative homodimer interface [polypeptide binding]; other site 262316002302 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262316002303 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 262316002304 putative substrate binding site [chemical binding]; other site 262316002305 putative ATP binding site [chemical binding]; other site 262316002306 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 262316002307 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262316002308 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262316002309 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 262316002310 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 262316002311 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262316002312 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262316002313 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 262316002314 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 262316002315 nucleotide binding site [chemical binding]; other site 262316002316 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 262316002317 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 262316002318 active site 262316002319 DNA binding site [nucleotide binding] 262316002320 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 262316002321 DNA binding site [nucleotide binding] 262316002322 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 262316002323 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 262316002324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316002325 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316002326 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316002327 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316002328 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316002329 substrate binding site [chemical binding]; other site 262316002330 oxyanion hole (OAH) forming residues; other site 262316002331 trimer interface [polypeptide binding]; other site 262316002332 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002333 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316002334 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316002335 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316002336 anti sigma factor interaction site; other site 262316002337 regulatory phosphorylation site [posttranslational modification]; other site 262316002338 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 262316002339 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 262316002340 active site 262316002341 SAM binding site [chemical binding]; other site 262316002342 homodimer interface [polypeptide binding]; other site 262316002343 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 262316002344 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 262316002345 putative DNA binding site [nucleotide binding]; other site 262316002346 catalytic residue [active] 262316002347 putative H2TH interface [polypeptide binding]; other site 262316002348 putative catalytic residues [active] 262316002349 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316002350 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316002351 short chain dehydrogenase; Provisional; Region: PRK08251 262316002352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316002353 NAD(P) binding site [chemical binding]; other site 262316002354 active site 262316002355 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 262316002356 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 262316002357 active site 262316002358 dimer interface [polypeptide binding]; other site 262316002359 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 262316002360 dimer interface [polypeptide binding]; other site 262316002361 active site 262316002362 hypothetical protein; Provisional; Region: PRK07857 262316002363 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 262316002364 Part of AAA domain; Region: AAA_19; pfam13245 262316002365 Family description; Region: UvrD_C_2; pfam13538 262316002366 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262316002367 Peptidase family M23; Region: Peptidase_M23; pfam01551 262316002368 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 262316002369 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 262316002370 CoA-ligase; Region: Ligase_CoA; pfam00549 262316002371 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 262316002372 CoA binding domain; Region: CoA_binding; smart00881 262316002373 CoA-ligase; Region: Ligase_CoA; pfam00549 262316002374 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 262316002375 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316002376 active site 262316002377 Omptin family; Region: Omptin; cl01886 262316002378 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316002379 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002380 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 262316002381 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 262316002382 active site 262316002383 cosubstrate binding site; other site 262316002384 substrate binding site [chemical binding]; other site 262316002385 catalytic site [active] 262316002386 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 262316002387 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 262316002388 purine monophosphate binding site [chemical binding]; other site 262316002389 dimer interface [polypeptide binding]; other site 262316002390 putative catalytic residues [active] 262316002391 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 262316002392 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 262316002393 LGFP repeat; Region: LGFP; pfam08310 262316002394 LGFP repeat; Region: LGFP; pfam08310 262316002395 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 262316002396 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 262316002397 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 262316002398 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316002399 metal ion-dependent adhesion site (MIDAS); other site 262316002400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316002401 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316002402 active site 262316002403 catalytic tetrad [active] 262316002404 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 262316002405 enoyl-CoA hydratase; Provisional; Region: PRK07827 262316002406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316002407 substrate binding site [chemical binding]; other site 262316002408 oxyanion hole (OAH) forming residues; other site 262316002409 trimer interface [polypeptide binding]; other site 262316002410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316002411 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316002412 active site 262316002413 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 262316002414 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316002415 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316002416 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 262316002417 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262316002418 carboxyltransferase (CT) interaction site; other site 262316002419 biotinylation site [posttranslational modification]; other site 262316002420 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316002421 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316002422 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316002423 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316002424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002425 active site 262316002426 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 262316002427 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316002428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316002429 active site 262316002430 phosphorylation site [posttranslational modification] 262316002431 intermolecular recognition site; other site 262316002432 dimerization interface [polypeptide binding]; other site 262316002433 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316002434 DNA binding site [nucleotide binding] 262316002435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316002436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316002437 dimerization interface [polypeptide binding]; other site 262316002438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316002439 dimer interface [polypeptide binding]; other site 262316002440 phosphorylation site [posttranslational modification] 262316002441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002442 ATP binding site [chemical binding]; other site 262316002443 Mg2+ binding site [ion binding]; other site 262316002444 G-X-G motif; other site 262316002445 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 262316002446 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262316002447 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 262316002448 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 262316002449 MPT binding site; other site 262316002450 trimer interface [polypeptide binding]; other site 262316002451 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 262316002452 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 262316002453 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 262316002454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 262316002455 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 262316002456 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 262316002457 active site 262316002458 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 262316002459 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 262316002460 dimer interface [polypeptide binding]; other site 262316002461 putative functional site; other site 262316002462 putative MPT binding site; other site 262316002463 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 262316002464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262316002465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002467 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316002468 CoenzymeA binding site [chemical binding]; other site 262316002469 subunit interaction site [polypeptide binding]; other site 262316002470 PHB binding site; other site 262316002471 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 262316002472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002473 DNA-binding interface [nucleotide binding]; DNA binding site 262316002474 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316002475 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316002476 [2Fe-2S] cluster binding site [ion binding]; other site 262316002477 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 262316002478 putative alpha subunit interface [polypeptide binding]; other site 262316002479 putative active site [active] 262316002480 putative substrate binding site [chemical binding]; other site 262316002481 Fe binding site [ion binding]; other site 262316002482 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 262316002483 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 262316002484 metal binding site [ion binding]; metal-binding site 262316002485 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 262316002486 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 262316002487 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 262316002488 active site 262316002489 dimer interface [polypeptide binding]; other site 262316002490 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 262316002491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316002492 active site 262316002493 motif I; other site 262316002494 motif II; other site 262316002495 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262316002496 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316002497 ligand binding site [chemical binding]; other site 262316002498 flexible hinge region; other site 262316002499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262316002500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316002501 Coenzyme A binding pocket [chemical binding]; other site 262316002502 arginine deiminase; Provisional; Region: PRK01388 262316002503 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 262316002504 Predicted methyltransferases [General function prediction only]; Region: COG0313 262316002505 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 262316002506 putative SAM binding site [chemical binding]; other site 262316002507 putative homodimer interface [polypeptide binding]; other site 262316002508 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 262316002509 chorismate binding enzyme; Region: Chorismate_bind; cl10555 262316002510 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 262316002511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316002512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316002513 DNA binding residues [nucleotide binding] 262316002514 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316002515 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316002516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316002517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316002518 GAF domain; Region: GAF; cl17456 262316002519 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262316002520 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316002521 metal binding site [ion binding]; metal-binding site 262316002522 active site 262316002523 I-site; other site 262316002524 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262316002525 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 262316002526 Chain length determinant protein; Region: Wzz; pfam02706 262316002527 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 262316002528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316002529 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316002530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316002531 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316002532 catalytic tetrad [active] 262316002533 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 262316002534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316002535 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316002536 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 262316002537 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262316002538 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 262316002539 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 262316002540 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 262316002541 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262316002542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316002543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316002544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316002545 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316002546 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 262316002547 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 262316002548 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 262316002549 Bacterial sugar transferase; Region: Bac_transf; pfam02397 262316002550 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 262316002551 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316002552 PPE family; Region: PPE; pfam00823 262316002553 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316002554 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316002555 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316002556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002560 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 262316002561 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 262316002562 putative active site [active] 262316002563 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 262316002564 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 262316002565 active site 262316002566 HIGH motif; other site 262316002567 KMSKS motif; other site 262316002568 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 262316002569 tRNA binding surface [nucleotide binding]; other site 262316002570 anticodon binding site; other site 262316002571 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 262316002572 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 262316002573 active site 262316002574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 262316002575 Domain of unknown function (DUF348); Region: DUF348; pfam03990 262316002576 Domain of unknown function (DUF348); Region: DUF348; pfam03990 262316002577 G5 domain; Region: G5; pfam07501 262316002578 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 262316002579 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 262316002580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316002581 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 262316002582 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 262316002583 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316002584 acyl-activating enzyme (AAE) consensus motif; other site 262316002585 active site 262316002586 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 262316002587 putative active site [active] 262316002588 catalytic residue [active] 262316002589 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 262316002590 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 262316002591 5S rRNA interface [nucleotide binding]; other site 262316002592 CTC domain interface [polypeptide binding]; other site 262316002593 L16 interface [polypeptide binding]; other site 262316002594 short chain dehydrogenase; Provisional; Region: PRK06197 262316002595 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316002596 putative NAD(P) binding site [chemical binding]; other site 262316002597 active site 262316002598 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 262316002599 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 262316002600 ArsC family; Region: ArsC; pfam03960 262316002601 catalytic residues [active] 262316002602 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 262316002603 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 262316002604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316002605 active site 262316002606 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 262316002607 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 262316002608 Substrate binding site; other site 262316002609 Mg++ binding site; other site 262316002610 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 262316002611 active site 262316002612 substrate binding site [chemical binding]; other site 262316002613 CoA binding site [chemical binding]; other site 262316002614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316002615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316002616 diaminopimelate decarboxylase; Region: lysA; TIGR01048 262316002617 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 262316002618 active site 262316002619 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316002620 substrate binding site [chemical binding]; other site 262316002621 catalytic residues [active] 262316002622 dimer interface [polypeptide binding]; other site 262316002623 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 262316002624 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 262316002625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316002626 ATP binding site [chemical binding]; other site 262316002627 putative Mg++ binding site [ion binding]; other site 262316002628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316002629 nucleotide binding region [chemical binding]; other site 262316002630 ATP-binding site [chemical binding]; other site 262316002631 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 262316002632 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 262316002633 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 262316002634 homodimer interface [polypeptide binding]; other site 262316002635 metal binding site [ion binding]; metal-binding site 262316002636 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 262316002637 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 262316002638 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262316002639 enolase; Provisional; Region: eno; PRK00077 262316002640 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 262316002641 dimer interface [polypeptide binding]; other site 262316002642 metal binding site [ion binding]; metal-binding site 262316002643 substrate binding pocket [chemical binding]; other site 262316002644 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 262316002645 Septum formation initiator; Region: DivIC; pfam04977 262316002646 Uncharacterized conserved protein [Function unknown]; Region: COG1507 262316002647 exopolyphosphatase; Region: exo_poly_only; TIGR03706 262316002648 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 262316002649 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 262316002650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316002651 active site 262316002652 phosphorylation site [posttranslational modification] 262316002653 intermolecular recognition site; other site 262316002654 dimerization interface [polypeptide binding]; other site 262316002655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316002656 DNA binding site [nucleotide binding] 262316002657 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 262316002658 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 262316002659 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 262316002660 Ligand Binding Site [chemical binding]; other site 262316002661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316002662 dimer interface [polypeptide binding]; other site 262316002663 phosphorylation site [posttranslational modification] 262316002664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002665 ATP binding site [chemical binding]; other site 262316002666 Mg2+ binding site [ion binding]; other site 262316002667 G-X-G motif; other site 262316002668 K+-transporting ATPase, c chain; Region: KdpC; cl00944 262316002669 K+-transporting ATPase, c chain; Region: KdpC; cl00944 262316002670 Soluble P-type ATPase [General function prediction only]; Region: COG4087 262316002671 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316002672 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 262316002673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316002674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316002675 dimer interface [polypeptide binding]; other site 262316002676 phosphorylation site [posttranslational modification] 262316002677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316002678 ATP binding site [chemical binding]; other site 262316002679 Mg2+ binding site [ion binding]; other site 262316002680 G-X-G motif; other site 262316002681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316002682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316002683 active site 262316002684 phosphorylation site [posttranslational modification] 262316002685 intermolecular recognition site; other site 262316002686 dimerization interface [polypeptide binding]; other site 262316002687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316002688 DNA binding site [nucleotide binding] 262316002689 PE family; Region: PE; pfam00934 262316002690 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316002691 PPE family; Region: PPE; pfam00823 262316002692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262316002693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316002694 S-adenosylmethionine binding site [chemical binding]; other site 262316002695 Domain of unknown function (DUF427); Region: DUF427; cl00998 262316002696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 262316002697 Uncharacterized conserved protein [Function unknown]; Region: COG3391 262316002698 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 262316002699 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 262316002700 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 262316002701 dimer interface [polypeptide binding]; other site 262316002702 acyl-activating enzyme (AAE) consensus motif; other site 262316002703 putative active site [active] 262316002704 AMP binding site [chemical binding]; other site 262316002705 putative CoA binding site [chemical binding]; other site 262316002706 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 262316002707 putative hydrophobic ligand binding site [chemical binding]; other site 262316002708 protein interface [polypeptide binding]; other site 262316002709 gate; other site 262316002710 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 262316002711 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 262316002712 putative active site [active] 262316002713 putative dimer interface [polypeptide binding]; other site 262316002714 Patatin-like phospholipase; Region: Patatin; pfam01734 262316002715 nucleophile elbow; other site 262316002716 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 262316002717 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 262316002718 active site 262316002719 nucleophile elbow; other site 262316002720 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 262316002721 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 262316002722 active site residue [active] 262316002723 Predicted membrane protein [Function unknown]; Region: COG4425 262316002724 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 262316002725 enoyl-CoA hydratase; Provisional; Region: PRK05862 262316002726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316002727 substrate binding site [chemical binding]; other site 262316002728 oxyanion hole (OAH) forming residues; other site 262316002729 trimer interface [polypeptide binding]; other site 262316002730 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 262316002731 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316002732 substrate binding site [chemical binding]; other site 262316002733 oxyanion hole (OAH) forming residues; other site 262316002734 trimer interface [polypeptide binding]; other site 262316002735 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 262316002736 Bax inhibitor 1 like; Region: BaxI_1; cl17691 262316002737 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316002738 active site 262316002739 Thiolase, N-terminal domain; Region: Thiolase_N; pfam00108 262316002740 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316002741 dimer interface [polypeptide binding]; other site 262316002742 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 262316002743 active site 262316002744 catalytic triad [active] 262316002745 oxyanion hole [active] 262316002746 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316002747 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316002748 substrate binding pocket [chemical binding]; other site 262316002749 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 262316002750 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 262316002751 dimer interface [polypeptide binding]; other site 262316002752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316002753 catalytic residue [active] 262316002754 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 262316002755 RDD family; Region: RDD; pfam06271 262316002756 cystathionine gamma-synthase; Provisional; Region: PRK07811 262316002757 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 262316002758 homodimer interface [polypeptide binding]; other site 262316002759 substrate-cofactor binding pocket; other site 262316002760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316002761 catalytic residue [active] 262316002762 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 262316002763 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 262316002764 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 262316002765 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 262316002766 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 262316002767 hypothetical protein; Validated; Region: PRK00110 262316002768 spermidine synthase; Provisional; Region: PRK03612 262316002769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316002770 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 262316002771 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316002772 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316002773 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 262316002774 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 262316002775 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 262316002776 active site 262316002777 putative DNA-binding cleft [nucleotide binding]; other site 262316002778 dimer interface [polypeptide binding]; other site 262316002779 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 262316002780 RuvA N terminal domain; Region: RuvA_N; pfam01330 262316002781 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 262316002782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316002783 Walker A motif; other site 262316002784 ATP binding site [chemical binding]; other site 262316002785 Walker B motif; other site 262316002786 arginine finger; other site 262316002787 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 262316002788 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316002789 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316002790 acyl-activating enzyme (AAE) consensus motif; other site 262316002791 AMP binding site [chemical binding]; other site 262316002792 active site 262316002793 CoA binding site [chemical binding]; other site 262316002794 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316002795 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 262316002796 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 262316002797 putative NAD(P) binding site [chemical binding]; other site 262316002798 active site 262316002799 putative substrate binding site [chemical binding]; other site 262316002800 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 262316002801 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262316002802 inhibitor-cofactor binding pocket; inhibition site 262316002803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316002804 catalytic residue [active] 262316002805 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 262316002806 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 262316002807 Protein export membrane protein; Region: SecD_SecF; cl14618 262316002808 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 262316002809 Protein export membrane protein; Region: SecD_SecF; pfam02355 262316002810 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262316002811 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 262316002812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316002813 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 262316002814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262316002815 Zn2+ binding site [ion binding]; other site 262316002816 Mg2+ binding site [ion binding]; other site 262316002817 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 262316002818 synthetase active site [active] 262316002819 NTP binding site [chemical binding]; other site 262316002820 metal binding site [ion binding]; metal-binding site 262316002821 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 262316002822 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 262316002823 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 262316002824 Winged helix-turn helix; Region: HTH_29; pfam13551 262316002825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316002826 Integrase core domain; Region: rve; pfam00665 262316002827 Integrase core domain; Region: rve_3; pfam13683 262316002828 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316002829 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316002830 active site 262316002831 ATP binding site [chemical binding]; other site 262316002832 substrate binding site [chemical binding]; other site 262316002833 activation loop (A-loop); other site 262316002834 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 262316002835 active site 262316002836 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 262316002837 active site 262316002838 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 262316002839 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 262316002840 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 262316002841 dimer interface [polypeptide binding]; other site 262316002842 motif 1; other site 262316002843 active site 262316002844 motif 2; other site 262316002845 motif 3; other site 262316002846 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 262316002847 anticodon binding site; other site 262316002848 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316002849 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316002850 active site 262316002851 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 262316002852 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262316002853 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 262316002854 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262316002855 active site 262316002856 metal binding site [ion binding]; metal-binding site 262316002857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316002858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316002859 non-specific DNA binding site [nucleotide binding]; other site 262316002860 salt bridge; other site 262316002861 sequence-specific DNA binding site [nucleotide binding]; other site 262316002862 Cupin domain; Region: Cupin_2; pfam07883 262316002863 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 262316002864 intersubunit interface [polypeptide binding]; other site 262316002865 active site 262316002866 Zn2+ binding site [ion binding]; other site 262316002867 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 262316002868 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 262316002869 inhibitor site; inhibition site 262316002870 active site 262316002871 dimer interface [polypeptide binding]; other site 262316002872 catalytic residue [active] 262316002873 Predicted metalloprotease [General function prediction only]; Region: COG2321 262316002874 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 262316002875 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 262316002876 putative hydrophobic ligand binding site [chemical binding]; other site 262316002877 protein interface [polypeptide binding]; other site 262316002878 gate; other site 262316002879 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 262316002880 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 262316002881 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 262316002882 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 262316002883 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 262316002884 dimer interface [polypeptide binding]; other site 262316002885 anticodon binding site; other site 262316002886 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 262316002887 homodimer interface [polypeptide binding]; other site 262316002888 motif 1; other site 262316002889 active site 262316002890 motif 2; other site 262316002891 GAD domain; Region: GAD; pfam02938 262316002892 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316002893 active site 262316002894 motif 3; other site 262316002895 Domain of unknown function (DUF385); Region: DUF385; pfam04075 262316002896 Predicted membrane protein [Function unknown]; Region: COG4129 262316002897 Protein of unknown function (DUF419); Region: DUF419; cl15265 262316002898 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 262316002899 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 262316002900 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 262316002901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 262316002902 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 262316002903 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 262316002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 262316002905 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 262316002906 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 262316002907 recombination factor protein RarA; Reviewed; Region: PRK13342 262316002908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316002909 Walker A motif; other site 262316002910 ATP binding site [chemical binding]; other site 262316002911 Walker B motif; other site 262316002912 arginine finger; other site 262316002913 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 262316002914 Uncharacterized conserved protein [Function unknown]; Region: COG0432 262316002915 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 262316002916 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 262316002917 motif 1; other site 262316002918 active site 262316002919 motif 2; other site 262316002920 motif 3; other site 262316002921 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 262316002922 DHHA1 domain; Region: DHHA1; pfam02272 262316002923 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 262316002924 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 262316002925 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 262316002926 dimerization interface [polypeptide binding]; other site 262316002927 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 262316002928 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 262316002929 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 262316002930 NAD(P) binding site [chemical binding]; other site 262316002931 shikimate binding site; other site 262316002932 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 262316002933 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 262316002934 active site 262316002935 dimer interface [polypeptide binding]; other site 262316002936 non-prolyl cis peptide bond; other site 262316002937 insertion regions; other site 262316002938 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 262316002939 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 262316002940 active site 262316002941 non-prolyl cis peptide bond; other site 262316002942 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316002943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316002944 active site 262316002945 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 262316002946 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262316002947 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262316002948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 262316002949 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262316002950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 262316002951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 262316002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316002953 dimer interface [polypeptide binding]; other site 262316002954 conserved gate region; other site 262316002955 putative PBP binding loops; other site 262316002956 ABC-ATPase subunit interface; other site 262316002957 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 262316002958 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262316002959 Walker A/P-loop; other site 262316002960 ATP binding site [chemical binding]; other site 262316002961 Q-loop/lid; other site 262316002962 ABC transporter signature motif; other site 262316002963 Walker B; other site 262316002964 D-loop; other site 262316002965 H-loop/switch region; other site 262316002966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262316002967 Walker A/P-loop; other site 262316002968 ATP binding site [chemical binding]; other site 262316002969 Q-loop/lid; other site 262316002970 ABC transporter signature motif; other site 262316002971 Walker B; other site 262316002972 D-loop; other site 262316002973 H-loop/switch region; other site 262316002974 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 262316002975 chorismate synthase; Validated; Region: PRK05382 262316002976 Tetramer interface [polypeptide binding]; other site 262316002977 active site 262316002978 FMN-binding site [chemical binding]; other site 262316002979 shikimate kinase; Reviewed; Region: aroK; PRK00131 262316002980 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 262316002981 ADP binding site [chemical binding]; other site 262316002982 magnesium binding site [ion binding]; other site 262316002983 putative shikimate binding site; other site 262316002984 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 262316002985 active site 262316002986 dimer interface [polypeptide binding]; other site 262316002987 metal binding site [ion binding]; metal-binding site 262316002988 Dehydroquinase class II; Region: DHquinase_II; pfam01220 262316002989 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 262316002990 trimer interface [polypeptide binding]; other site 262316002991 active site 262316002992 dimer interface [polypeptide binding]; other site 262316002993 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316002994 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316002995 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 262316002996 active site 262316002997 elongation factor P; Validated; Region: PRK00529 262316002998 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 262316002999 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 262316003000 RNA binding site [nucleotide binding]; other site 262316003001 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 262316003002 RNA binding site [nucleotide binding]; other site 262316003003 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 262316003004 putative RNA binding site [nucleotide binding]; other site 262316003005 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 262316003006 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316003007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316003008 catalytic residue [active] 262316003009 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 262316003010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316003011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316003012 dimerization interface [polypeptide binding]; other site 262316003013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316003014 dimer interface [polypeptide binding]; other site 262316003015 phosphorylation site [posttranslational modification] 262316003016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316003017 ATP binding site [chemical binding]; other site 262316003018 Mg2+ binding site [ion binding]; other site 262316003019 G-X-G motif; other site 262316003020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316003021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316003022 active site 262316003023 phosphorylation site [posttranslational modification] 262316003024 intermolecular recognition site; other site 262316003025 dimerization interface [polypeptide binding]; other site 262316003026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316003027 DNA binding site [nucleotide binding] 262316003028 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316003029 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316003030 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316003031 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 262316003032 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262316003033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316003034 DNA-binding site [nucleotide binding]; DNA binding site 262316003035 UTRA domain; Region: UTRA; pfam07702 262316003036 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 262316003037 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 262316003038 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 262316003039 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 262316003040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316003041 dimer interface [polypeptide binding]; other site 262316003042 conserved gate region; other site 262316003043 putative PBP binding loops; other site 262316003044 ABC-ATPase subunit interface; other site 262316003045 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 262316003046 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 262316003047 Walker A/P-loop; other site 262316003048 ATP binding site [chemical binding]; other site 262316003049 Q-loop/lid; other site 262316003050 ABC transporter signature motif; other site 262316003051 Walker B; other site 262316003052 D-loop; other site 262316003053 H-loop/switch region; other site 262316003054 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 262316003055 L-aspartate oxidase; Provisional; Region: PRK06175 262316003056 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 262316003057 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262316003058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262316003059 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316003060 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316003061 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 262316003062 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316003063 active site 262316003064 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 262316003065 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 262316003066 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 262316003067 dihydroorotase; Validated; Region: pyrC; PRK09357 262316003068 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316003069 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 262316003070 active site 262316003071 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 262316003072 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 262316003073 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 262316003074 catalytic site [active] 262316003075 subunit interface [polypeptide binding]; other site 262316003076 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 262316003077 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316003078 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316003079 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 262316003080 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316003081 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316003082 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 262316003083 IMP binding site; other site 262316003084 dimer interface [polypeptide binding]; other site 262316003085 interdomain contacts; other site 262316003086 partial ornithine binding site; other site 262316003087 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 262316003088 active site 262316003089 dimer interface [polypeptide binding]; other site 262316003090 Homeodomain-like domain; Region: HTH_23; pfam13384 262316003091 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 262316003092 DNA binding residues [nucleotide binding] 262316003093 TOBE domain; Region: TOBE; cl01440 262316003094 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 262316003095 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 262316003096 catalytic site [active] 262316003097 G-X2-G-X-G-K; other site 262316003098 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 262316003099 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 262316003100 Flavoprotein; Region: Flavoprotein; pfam02441 262316003101 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 262316003102 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 262316003103 S-adenosylmethionine synthetase; Validated; Region: PRK05250 262316003104 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 262316003105 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 262316003106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316003107 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316003108 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316003109 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316003110 substrate binding pocket [chemical binding]; other site 262316003111 Predicted membrane protein [Function unknown]; Region: COG3714 262316003112 primosome assembly protein PriA; Provisional; Region: PRK14873 262316003113 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316003114 MarR family; Region: MarR; pfam01047 262316003115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316003116 S-adenosylmethionine binding site [chemical binding]; other site 262316003117 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 262316003118 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 262316003119 putative active site [active] 262316003120 substrate binding site [chemical binding]; other site 262316003121 putative cosubstrate binding site; other site 262316003122 catalytic site [active] 262316003123 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 262316003124 substrate binding site [chemical binding]; other site 262316003125 16S rRNA methyltransferase B; Provisional; Region: PRK14902 262316003126 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 262316003127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316003128 S-adenosylmethionine binding site [chemical binding]; other site 262316003129 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 262316003130 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 262316003131 substrate binding site [chemical binding]; other site 262316003132 hexamer interface [polypeptide binding]; other site 262316003133 metal binding site [ion binding]; metal-binding site 262316003134 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 262316003135 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 262316003136 catalytic motif [active] 262316003137 Zn binding site [ion binding]; other site 262316003138 RibD C-terminal domain; Region: RibD_C; pfam01872 262316003139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316003140 putative substrate translocation pore; other site 262316003141 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 262316003142 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 262316003143 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 262316003144 Lumazine binding domain; Region: Lum_binding; pfam00677 262316003145 Lumazine binding domain; Region: Lum_binding; pfam00677 262316003146 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 262316003147 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 262316003148 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 262316003149 dimerization interface [polypeptide binding]; other site 262316003150 active site 262316003151 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 262316003152 homopentamer interface [polypeptide binding]; other site 262316003153 active site 262316003154 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 262316003155 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316003156 PPE family; Region: PPE; pfam00823 262316003157 Cupin superfamily protein; Region: Cupin_4; pfam08007 262316003158 Cupin-like domain; Region: Cupin_8; pfam13621 262316003159 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 262316003160 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 262316003161 GIY-YIG motif/motif A; other site 262316003162 active site 262316003163 catalytic site [active] 262316003164 putative DNA binding site [nucleotide binding]; other site 262316003165 metal binding site [ion binding]; metal-binding site 262316003166 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 262316003167 Helix-hairpin-helix motif; Region: HHH; pfam00633 262316003168 helix-hairpin-helix signature motif; other site 262316003169 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 262316003170 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 262316003171 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 262316003172 phosphate binding site [ion binding]; other site 262316003173 putative substrate binding pocket [chemical binding]; other site 262316003174 dimer interface [polypeptide binding]; other site 262316003175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 262316003176 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 262316003177 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316003178 MULE transposase domain; Region: MULE; pfam10551 262316003179 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316003180 PPE family; Region: PPE; pfam00823 262316003181 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316003182 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316003183 PPE family; Region: PPE; pfam00823 262316003184 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316003185 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316003186 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316003187 PPE family; Region: PPE; pfam00823 262316003188 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316003189 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316003190 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316003191 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316003192 substrate binding pocket [chemical binding]; other site 262316003193 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316003194 acyl-CoA synthetase; Provisional; Region: PRK13382 262316003195 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 262316003196 acyl-activating enzyme (AAE) consensus motif; other site 262316003197 putative AMP binding site [chemical binding]; other site 262316003198 putative active site [active] 262316003199 putative CoA binding site [chemical binding]; other site 262316003200 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316003201 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316003202 putative acyl-acceptor binding pocket; other site 262316003203 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 262316003204 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316003205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316003206 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 262316003207 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 262316003208 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 262316003209 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 262316003210 Phosphoglycerate kinase; Region: PGK; pfam00162 262316003211 substrate binding site [chemical binding]; other site 262316003212 hinge regions; other site 262316003213 ADP binding site [chemical binding]; other site 262316003214 catalytic site [active] 262316003215 triosephosphate isomerase; Provisional; Region: PRK14567 262316003216 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 262316003217 substrate binding site [chemical binding]; other site 262316003218 dimer interface [polypeptide binding]; other site 262316003219 catalytic triad [active] 262316003220 Preprotein translocase SecG subunit; Region: SecG; cl09123 262316003221 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316003222 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316003223 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 262316003224 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 262316003225 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 262316003226 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 262316003227 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316003228 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316003229 active site 262316003230 catalytic tetrad [active] 262316003231 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 262316003232 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 262316003233 putative active site [active] 262316003234 Zn binding site [ion binding]; other site 262316003235 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 262316003236 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 262316003237 putative active site [active] 262316003238 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 262316003239 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 262316003240 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 262316003241 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 262316003242 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 262316003243 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 262316003244 putative active site [active] 262316003245 transaldolase; Provisional; Region: PRK03903 262316003246 catalytic residue [active] 262316003247 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 262316003248 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 262316003249 TPP-binding site [chemical binding]; other site 262316003250 dimer interface [polypeptide binding]; other site 262316003251 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 262316003252 PYR/PP interface [polypeptide binding]; other site 262316003253 dimer interface [polypeptide binding]; other site 262316003254 TPP binding site [chemical binding]; other site 262316003255 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316003256 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 262316003257 UbiA prenyltransferase family; Region: UbiA; pfam01040 262316003258 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 262316003259 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 262316003260 NADP binding site [chemical binding]; other site 262316003261 dimer interface [polypeptide binding]; other site 262316003262 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 262316003263 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 262316003264 ABC-2 type transporter; Region: ABC2_membrane; cl17235 262316003265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262316003266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262316003267 Walker A/P-loop; other site 262316003268 ATP binding site [chemical binding]; other site 262316003269 Q-loop/lid; other site 262316003270 ABC transporter signature motif; other site 262316003271 Walker B; other site 262316003272 D-loop; other site 262316003273 H-loop/switch region; other site 262316003274 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 262316003275 Predicted transcriptional regulator [Transcription]; Region: COG2345 262316003276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316003277 putative DNA binding site [nucleotide binding]; other site 262316003278 putative Zn2+ binding site [ion binding]; other site 262316003279 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 262316003280 FeS assembly protein SufB; Region: sufB; TIGR01980 262316003281 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 262316003282 FeS assembly protein SufD; Region: sufD; TIGR01981 262316003283 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 262316003284 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 262316003285 Walker A/P-loop; other site 262316003286 ATP binding site [chemical binding]; other site 262316003287 Q-loop/lid; other site 262316003288 ABC transporter signature motif; other site 262316003289 Walker B; other site 262316003290 D-loop; other site 262316003291 H-loop/switch region; other site 262316003292 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316003293 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 262316003294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316003295 catalytic residue [active] 262316003296 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 262316003297 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 262316003298 trimerization site [polypeptide binding]; other site 262316003299 active site 262316003300 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 262316003301 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 262316003302 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 262316003303 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316003304 active site 262316003305 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 262316003306 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262316003307 catalytic residues [active] 262316003308 enoyl-CoA hydratase; Provisional; Region: PRK05864 262316003309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316003310 substrate binding site [chemical binding]; other site 262316003311 oxyanion hole (OAH) forming residues; other site 262316003312 trimer interface [polypeptide binding]; other site 262316003313 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262316003314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316003315 Walker A/P-loop; other site 262316003316 ATP binding site [chemical binding]; other site 262316003317 Q-loop/lid; other site 262316003318 ABC transporter signature motif; other site 262316003319 Walker B; other site 262316003320 D-loop; other site 262316003321 H-loop/switch region; other site 262316003322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262316003323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316003324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003325 aconitate hydratase; Validated; Region: PRK09277 262316003326 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 262316003327 substrate binding site [chemical binding]; other site 262316003328 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 262316003329 ligand binding site [chemical binding]; other site 262316003330 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 262316003331 substrate binding site [chemical binding]; other site 262316003332 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262316003333 NlpC/P60 family; Region: NLPC_P60; pfam00877 262316003334 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262316003335 NlpC/P60 family; Region: NLPC_P60; pfam00877 262316003336 MoxR-like ATPases [General function prediction only]; Region: COG0714 262316003337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316003338 Walker A motif; other site 262316003339 ATP binding site [chemical binding]; other site 262316003340 Walker B motif; other site 262316003341 arginine finger; other site 262316003342 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262316003343 Protein of unknown function DUF58; Region: DUF58; pfam01882 262316003344 hypothetical protein; Provisional; Region: PRK13685 262316003345 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 262316003346 metal ion-dependent adhesion site (MIDAS); other site 262316003347 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 262316003348 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 262316003349 NAD(P) binding site [chemical binding]; other site 262316003350 homotetramer interface [polypeptide binding]; other site 262316003351 homodimer interface [polypeptide binding]; other site 262316003352 active site 262316003353 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 262316003354 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 262316003355 NAD binding site [chemical binding]; other site 262316003356 homotetramer interface [polypeptide binding]; other site 262316003357 homodimer interface [polypeptide binding]; other site 262316003358 substrate binding site [chemical binding]; other site 262316003359 active site 262316003360 ferrochelatase; Reviewed; Region: hemH; PRK00035 262316003361 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 262316003362 C-terminal domain interface [polypeptide binding]; other site 262316003363 active site 262316003364 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 262316003365 active site 262316003366 N-terminal domain interface [polypeptide binding]; other site 262316003367 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 262316003368 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 262316003369 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 262316003370 DoxX-like family; Region: DoxX_2; pfam13564 262316003371 PknH-like extracellular domain; Region: PknH_C; pfam14032 262316003372 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 262316003373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316003374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316003375 active site 262316003376 phosphorylation site [posttranslational modification] 262316003377 intermolecular recognition site; other site 262316003378 dimerization interface [polypeptide binding]; other site 262316003379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316003380 DNA binding site [nucleotide binding] 262316003381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316003382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316003383 dimerization interface [polypeptide binding]; other site 262316003384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316003385 dimer interface [polypeptide binding]; other site 262316003386 phosphorylation site [posttranslational modification] 262316003387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316003388 Mg2+ binding site [ion binding]; other site 262316003389 G-X-G motif; other site 262316003390 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 262316003391 Uncharacterized conserved protein [Function unknown]; Region: COG0398 262316003392 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262316003393 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 262316003394 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 262316003395 heterodimer interface [polypeptide binding]; other site 262316003396 substrate interaction site [chemical binding]; other site 262316003397 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 262316003398 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 262316003399 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 262316003400 active site 262316003401 substrate binding site [chemical binding]; other site 262316003402 coenzyme B12 binding site [chemical binding]; other site 262316003403 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 262316003404 B12 binding site [chemical binding]; other site 262316003405 cobalt ligand [ion binding]; other site 262316003406 membrane ATPase/protein kinase; Provisional; Region: PRK09435 262316003407 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 262316003408 Walker A; other site 262316003409 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316003410 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316003411 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316003412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 262316003413 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 262316003414 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 262316003415 NADP-binding site; other site 262316003416 homotetramer interface [polypeptide binding]; other site 262316003417 substrate binding site [chemical binding]; other site 262316003418 homodimer interface [polypeptide binding]; other site 262316003419 active site 262316003420 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 262316003421 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 262316003422 NADP binding site [chemical binding]; other site 262316003423 active site 262316003424 putative substrate binding site [chemical binding]; other site 262316003425 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 262316003426 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 262316003427 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 262316003428 metal-binding site 262316003429 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316003430 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 262316003431 daunorubicin resistance protein C; Region: drrC; TIGR01248 262316003432 ABC-2 type transporter; Region: ABC2_membrane; cl17235 262316003433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316003434 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 262316003435 Walker A/P-loop; other site 262316003436 ATP binding site [chemical binding]; other site 262316003437 Q-loop/lid; other site 262316003438 ABC transporter signature motif; other site 262316003439 Walker B; other site 262316003440 D-loop; other site 262316003441 H-loop/switch region; other site 262316003442 Transport protein; Region: actII; TIGR00833 262316003443 Transport protein; Region: actII; TIGR00833 262316003444 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316003445 Condensation domain; Region: Condensation; pfam00668 262316003446 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316003447 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003448 acyl-activating enzyme (AAE) consensus motif; other site 262316003449 AMP binding site [chemical binding]; other site 262316003450 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316003451 Condensation domain; Region: Condensation; pfam00668 262316003452 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 262316003453 Condensation domain; Region: Condensation; pfam00668 262316003454 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316003455 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316003456 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316003457 acyl-activating enzyme (AAE) consensus motif; other site 262316003458 AMP binding site [chemical binding]; other site 262316003459 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316003460 Condensation domain; Region: Condensation; pfam00668 262316003461 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316003462 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316003463 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316003464 acyl-activating enzyme (AAE) consensus motif; other site 262316003465 AMP binding site [chemical binding]; other site 262316003466 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316003467 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 262316003468 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 262316003469 putative NAD(P) binding site [chemical binding]; other site 262316003470 active site 262316003471 putative substrate binding site [chemical binding]; other site 262316003472 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316003473 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316003474 Nitronate monooxygenase; Region: NMO; pfam03060 262316003475 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262316003476 FMN binding site [chemical binding]; other site 262316003477 substrate binding site [chemical binding]; other site 262316003478 putative catalytic residue [active] 262316003479 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 262316003480 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 262316003481 HIGH motif; other site 262316003482 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 262316003483 active site 262316003484 KMSKS motif; other site 262316003485 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 262316003486 tRNA binding surface [nucleotide binding]; other site 262316003487 anticodon binding site; other site 262316003488 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 262316003489 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316003490 putative active site [active] 262316003491 DNA polymerase IV; Provisional; Region: PRK03348 262316003492 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262316003493 active site 262316003494 DNA binding site [nucleotide binding] 262316003495 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 262316003496 active site 262316003497 homodimer interface [polypeptide binding]; other site 262316003498 homotetramer interface [polypeptide binding]; other site 262316003499 lipoprotein signal peptidase; Provisional; Region: PRK14764 262316003500 lipoprotein signal peptidase; Provisional; Region: PRK14787 262316003501 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 262316003502 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 262316003503 active site 262316003504 Methyltransferase domain; Region: Methyltransf_11; pfam08241 262316003505 S-adenosylmethionine binding site [chemical binding]; other site 262316003506 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 262316003507 apolar tunnel; other site 262316003508 heme binding site [chemical binding]; other site 262316003509 dimerization interface [polypeptide binding]; other site 262316003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003511 NAD(P) binding site [chemical binding]; other site 262316003512 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316003513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003514 NAD(P) binding site [chemical binding]; other site 262316003515 active site 262316003516 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316003517 hydrophobic ligand binding site; other site 262316003518 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 262316003519 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 262316003520 active site 262316003521 PHP Thumb interface [polypeptide binding]; other site 262316003522 metal binding site [ion binding]; metal-binding site 262316003523 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 262316003524 generic binding surface II; other site 262316003525 generic binding surface I; other site 262316003526 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 262316003527 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 262316003528 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316003529 DNA binding residues [nucleotide binding] 262316003530 putative dimer interface [polypeptide binding]; other site 262316003531 putative metal binding residues [ion binding]; other site 262316003532 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316003533 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 262316003534 acyl-activating enzyme (AAE) consensus motif; other site 262316003535 putative AMP binding site [chemical binding]; other site 262316003536 putative active site [active] 262316003537 putative CoA binding site [chemical binding]; other site 262316003538 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 262316003539 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 262316003540 putative acyl-acceptor binding pocket; other site 262316003541 Domain of unknown function (DUF385); Region: DUF385; pfam04075 262316003542 threonine dehydratase; Validated; Region: PRK08639 262316003543 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 262316003544 tetramer interface [polypeptide binding]; other site 262316003545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003546 catalytic residue [active] 262316003547 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 262316003548 putative Ile/Val binding site [chemical binding]; other site 262316003549 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 262316003550 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 262316003551 active site 262316003552 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 262316003553 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 262316003554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316003555 DNA-binding site [nucleotide binding]; DNA binding site 262316003556 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316003557 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316003558 catalytic residue [active] 262316003559 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 262316003560 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 262316003561 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 262316003562 catalytic site [active] 262316003563 active site 262316003564 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 262316003565 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 262316003566 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 262316003567 active site 262316003568 catalytic site [active] 262316003569 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 262316003570 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 262316003571 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 262316003572 active site 262316003573 catalytic site [active] 262316003574 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316003575 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262316003576 NlpC/P60 family; Region: NLPC_P60; pfam00877 262316003577 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 262316003578 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262316003579 inhibitor-cofactor binding pocket; inhibition site 262316003580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003581 catalytic residue [active] 262316003582 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 262316003583 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 262316003584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316003585 catalytic residue [active] 262316003586 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 262316003587 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 262316003588 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 262316003589 Mechanosensitive ion channel; Region: MS_channel; pfam00924 262316003590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316003591 dimerization interface [polypeptide binding]; other site 262316003592 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 262316003593 cyclase homology domain; Region: CHD; cd07302 262316003594 nucleotidyl binding site; other site 262316003595 metal binding site [ion binding]; metal-binding site 262316003596 dimer interface [polypeptide binding]; other site 262316003597 biotin synthase; Validated; Region: PRK06256 262316003598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262316003599 FeS/SAM binding site; other site 262316003600 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 262316003601 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 262316003602 Secretory lipase; Region: LIP; pfam03583 262316003603 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316003604 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316003605 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 262316003606 nudix motif; other site 262316003607 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 262316003608 quinolinate synthetase; Provisional; Region: PRK09375 262316003609 L-aspartate oxidase; Provisional; Region: PRK07804 262316003610 L-aspartate oxidase; Provisional; Region: PRK06175 262316003611 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 262316003612 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 262316003613 dimerization interface [polypeptide binding]; other site 262316003614 active site 262316003615 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316003616 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 262316003617 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 262316003618 NAD binding site [chemical binding]; other site 262316003619 dimerization interface [polypeptide binding]; other site 262316003620 product binding site; other site 262316003621 substrate binding site [chemical binding]; other site 262316003622 zinc binding site [ion binding]; other site 262316003623 catalytic residues [active] 262316003624 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 262316003625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316003626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003627 homodimer interface [polypeptide binding]; other site 262316003628 catalytic residue [active] 262316003629 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 262316003630 putative active site pocket [active] 262316003631 4-fold oligomerization interface [polypeptide binding]; other site 262316003632 metal binding residues [ion binding]; metal-binding site 262316003633 3-fold/trimer interface [polypeptide binding]; other site 262316003634 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 262316003635 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 262316003636 putative active site [active] 262316003637 oxyanion strand; other site 262316003638 catalytic triad [active] 262316003639 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 262316003640 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 262316003641 catalytic residues [active] 262316003642 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 262316003643 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 262316003644 active site 262316003645 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 262316003646 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 262316003647 substrate binding site [chemical binding]; other site 262316003648 glutamase interaction surface [polypeptide binding]; other site 262316003649 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 262316003650 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 262316003651 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 262316003652 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 262316003653 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 262316003654 catalytic triad [active] 262316003655 anthranilate synthase component I; Provisional; Region: PRK13571 262316003656 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 262316003657 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 262316003658 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 262316003659 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 262316003660 active site 262316003661 ribulose/triose binding site [chemical binding]; other site 262316003662 phosphate binding site [ion binding]; other site 262316003663 substrate (anthranilate) binding pocket [chemical binding]; other site 262316003664 product (indole) binding pocket [chemical binding]; other site 262316003665 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 262316003666 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 262316003667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003668 catalytic residue [active] 262316003669 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 262316003670 substrate binding site [chemical binding]; other site 262316003671 active site 262316003672 catalytic residues [active] 262316003673 heterodimer interface [polypeptide binding]; other site 262316003674 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 262316003675 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 262316003676 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 262316003677 pyruvate kinase; Provisional; Region: PRK06247 262316003678 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 262316003679 domain interfaces; other site 262316003680 active site 262316003681 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 262316003682 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316003683 active site 262316003684 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316003685 catalytic triad [active] 262316003686 dimer interface [polypeptide binding]; other site 262316003687 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 262316003688 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 262316003689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316003690 Walker A/P-loop; other site 262316003691 ATP binding site [chemical binding]; other site 262316003692 Q-loop/lid; other site 262316003693 ABC transporter signature motif; other site 262316003694 Walker B; other site 262316003695 D-loop; other site 262316003696 H-loop/switch region; other site 262316003697 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 262316003698 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 262316003699 Walker A/P-loop; other site 262316003700 ATP binding site [chemical binding]; other site 262316003701 Q-loop/lid; other site 262316003702 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 262316003703 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 262316003704 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 262316003705 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 262316003706 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 262316003707 Heme NO binding associated; Region: HNOBA; pfam07701 262316003708 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 262316003709 cyclase homology domain; Region: CHD; cd07302 262316003710 nucleotidyl binding site; other site 262316003711 metal binding site [ion binding]; metal-binding site 262316003712 dimer interface [polypeptide binding]; other site 262316003713 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 262316003714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316003715 active site 262316003716 phosphorylation site [posttranslational modification] 262316003717 intermolecular recognition site; other site 262316003718 dimerization interface [polypeptide binding]; other site 262316003719 ANTAR domain; Region: ANTAR; pfam03861 262316003720 lipid-transfer protein; Provisional; Region: PRK06059 262316003721 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316003722 active site 262316003723 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 262316003724 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316003725 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316003726 5'-3' exonuclease; Region: 53EXOc; smart00475 262316003727 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 262316003728 active site 262316003729 metal binding site 1 [ion binding]; metal-binding site 262316003730 putative 5' ssDNA interaction site; other site 262316003731 metal binding site 3; metal-binding site 262316003732 metal binding site 2 [ion binding]; metal-binding site 262316003733 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 262316003734 putative DNA binding site [nucleotide binding]; other site 262316003735 putative metal binding site [ion binding]; other site 262316003736 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 262316003737 DNA polymerase I; Provisional; Region: PRK05755 262316003738 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 262316003739 active site 262316003740 DNA binding site [nucleotide binding] 262316003741 catalytic site [active] 262316003742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316003743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003744 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 262316003745 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 262316003746 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 262316003747 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 262316003748 RNA binding site [nucleotide binding]; other site 262316003749 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 262316003750 RNA binding site [nucleotide binding]; other site 262316003751 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 262316003752 RNA binding site [nucleotide binding]; other site 262316003753 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 262316003754 RNA binding site [nucleotide binding]; other site 262316003755 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 262316003756 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 262316003757 CoA-binding site [chemical binding]; other site 262316003758 ATP-binding [chemical binding]; other site 262316003759 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 262316003760 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 262316003761 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 262316003762 DNA binding site [nucleotide binding] 262316003763 catalytic residue [active] 262316003764 H2TH interface [polypeptide binding]; other site 262316003765 putative catalytic residues [active] 262316003766 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316003767 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316003768 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 262316003769 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 262316003770 active site 262316003771 DNA binding site [nucleotide binding] 262316003772 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 262316003773 DNA binding site [nucleotide binding] 262316003774 Protein of unknown function (DUF402); Region: DUF402; cl00979 262316003775 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316003776 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316003777 phosphopeptide binding site; other site 262316003778 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316003779 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316003780 phosphopeptide binding site; other site 262316003781 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316003782 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 262316003783 Walker A/P-loop; other site 262316003784 ATP binding site [chemical binding]; other site 262316003785 Q-loop/lid; other site 262316003786 ABC transporter signature motif; other site 262316003787 Walker B; other site 262316003788 D-loop; other site 262316003789 H-loop/switch region; other site 262316003790 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 262316003791 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 262316003792 Protein kinase domain; Region: Pkinase; pfam00069 262316003793 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316003794 active site 262316003795 ATP binding site [chemical binding]; other site 262316003796 substrate binding site [chemical binding]; other site 262316003797 activation loop (A-loop); other site 262316003798 excinuclease ABC subunit B; Provisional; Region: PRK05298 262316003799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316003800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316003801 nucleotide binding region [chemical binding]; other site 262316003802 ATP-binding site [chemical binding]; other site 262316003803 Ultra-violet resistance protein B; Region: UvrB; pfam12344 262316003804 UvrB/uvrC motif; Region: UVR; pfam02151 262316003805 MgtC family; Region: MgtC; pfam02308 262316003806 Predicted membrane protein [Function unknown]; Region: COG5305 262316003807 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316003808 Ligand Binding Site [chemical binding]; other site 262316003809 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 262316003810 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 262316003811 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 262316003812 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 262316003813 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 262316003814 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 262316003815 Cytochrome P450; Region: p450; cl12078 262316003816 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316003817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316003818 S-adenosylmethionine binding site [chemical binding]; other site 262316003819 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316003820 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262316003821 GAF domain; Region: GAF; pfam01590 262316003822 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262316003823 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 262316003824 hypothetical protein; Provisional; Region: PRK07877 262316003825 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 262316003826 ATP binding site [chemical binding]; other site 262316003827 substrate interface [chemical binding]; other site 262316003828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316003829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003830 Predicted esterase [General function prediction only]; Region: COG0627 262316003831 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 262316003832 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 262316003833 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 262316003834 dimer interface [polypeptide binding]; other site 262316003835 putative anticodon binding site; other site 262316003836 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316003837 motif 1; other site 262316003838 dimer interface [polypeptide binding]; other site 262316003839 active site 262316003840 motif 2; other site 262316003841 motif 3; other site 262316003842 translation initiation factor IF-3; Region: infC; TIGR00168 262316003843 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 262316003844 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 262316003845 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 262316003846 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 262316003847 23S rRNA binding site [nucleotide binding]; other site 262316003848 L21 binding site [polypeptide binding]; other site 262316003849 L13 binding site [polypeptide binding]; other site 262316003850 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262316003851 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 262316003852 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262316003853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 262316003854 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316003855 cyclase homology domain; Region: CHD; cd07302 262316003856 nucleotidyl binding site; other site 262316003857 metal binding site [ion binding]; metal-binding site 262316003858 dimer interface [polypeptide binding]; other site 262316003859 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 262316003860 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 262316003861 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 262316003862 dimer interface [polypeptide binding]; other site 262316003863 motif 1; other site 262316003864 active site 262316003865 motif 2; other site 262316003866 motif 3; other site 262316003867 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 262316003868 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 262316003869 putative tRNA-binding site [nucleotide binding]; other site 262316003870 B3/4 domain; Region: B3_4; pfam03483 262316003871 tRNA synthetase B5 domain; Region: B5; smart00874 262316003872 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 262316003873 dimer interface [polypeptide binding]; other site 262316003874 motif 1; other site 262316003875 motif 3; other site 262316003876 motif 2; other site 262316003877 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 262316003878 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 262316003879 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 262316003880 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 262316003881 heterotetramer interface [polypeptide binding]; other site 262316003882 active site pocket [active] 262316003883 cleavage site 262316003884 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 262316003885 feedback inhibition sensing region; other site 262316003886 homohexameric interface [polypeptide binding]; other site 262316003887 nucleotide binding site [chemical binding]; other site 262316003888 N-acetyl-L-glutamate binding site [chemical binding]; other site 262316003889 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 262316003890 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262316003891 inhibitor-cofactor binding pocket; inhibition site 262316003892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316003893 catalytic residue [active] 262316003894 ornithine carbamoyltransferase; Provisional; Region: PRK00779 262316003895 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 262316003896 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 262316003897 Arginine repressor [Transcription]; Region: ArgR; COG1438 262316003898 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 262316003899 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 262316003900 argininosuccinate synthase; Provisional; Region: PRK13820 262316003901 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 262316003902 ANP binding site [chemical binding]; other site 262316003903 Substrate Binding Site II [chemical binding]; other site 262316003904 Substrate Binding Site I [chemical binding]; other site 262316003905 argininosuccinate lyase; Provisional; Region: PRK00855 262316003906 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 262316003907 active sites [active] 262316003908 tetramer interface [polypeptide binding]; other site 262316003909 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 262316003910 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 262316003911 malonyl-CoA binding site [chemical binding]; other site 262316003912 dimer interface [polypeptide binding]; other site 262316003913 active site 262316003914 product binding site; other site 262316003915 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316003916 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 262316003917 active site 262316003918 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316003919 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316003920 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316003921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316003922 Enoylreductase; Region: PKS_ER; smart00829 262316003923 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316003924 NAD(P) binding site [chemical binding]; other site 262316003925 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 262316003926 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 262316003927 putative NADP binding site [chemical binding]; other site 262316003928 active site 262316003929 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316003930 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316003931 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316003932 active site 262316003933 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316003934 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316003935 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316003936 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 262316003937 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 262316003938 malonyl-CoA binding site [chemical binding]; other site 262316003939 dimer interface [polypeptide binding]; other site 262316003940 active site 262316003941 product binding site; other site 262316003942 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316003943 Cytochrome P450; Region: p450; cl12078 262316003944 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 262316003945 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262316003946 ABC transporter; Region: ABC_tran_2; pfam12848 262316003947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316003948 Walker A/P-loop; other site 262316003949 ATP binding site [chemical binding]; other site 262316003950 Q-loop/lid; other site 262316003951 ABC transporter signature motif; other site 262316003952 Walker B; other site 262316003953 D-loop; other site 262316003954 H-loop/switch region; other site 262316003955 PAS fold; Region: PAS_3; pfam08447 262316003956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316003957 putative active site [active] 262316003958 heme pocket [chemical binding]; other site 262316003959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316003960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316003961 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262316003962 dimerization interface [polypeptide binding]; other site 262316003963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316003964 classical (c) SDRs; Region: SDR_c; cd05233 262316003965 NAD(P) binding site [chemical binding]; other site 262316003966 active site 262316003967 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316003968 classical (c) SDRs; Region: SDR_c; cd05233 262316003969 NAD(P) binding site [chemical binding]; other site 262316003970 active site 262316003971 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316003972 classical (c) SDRs; Region: SDR_c; cd05233 262316003973 NAD(P) binding site [chemical binding]; other site 262316003974 active site 262316003975 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 262316003976 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 262316003977 putative active site pocket [active] 262316003978 putative metal binding site [ion binding]; other site 262316003979 short chain dehydrogenase; Provisional; Region: PRK07109 262316003980 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 262316003981 putative NAD(P) binding site [chemical binding]; other site 262316003982 active site 262316003983 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 262316003984 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 262316003985 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 262316003986 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316003987 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 262316003988 acyl-CoA synthetase; Validated; Region: PRK07868 262316003989 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316003990 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316003991 active site 262316003992 CoA binding site [chemical binding]; other site 262316003993 AMP binding site [chemical binding]; other site 262316003994 Uncharacterized conserved protein [Function unknown]; Region: COG2835 262316003995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316003996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316003997 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 262316003998 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 262316003999 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 262316004000 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262316004001 Walker A/P-loop; other site 262316004002 ATP binding site [chemical binding]; other site 262316004003 Q-loop/lid; other site 262316004004 ABC transporter signature motif; other site 262316004005 Walker B; other site 262316004006 D-loop; other site 262316004007 H-loop/switch region; other site 262316004008 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 262316004009 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 262316004010 active site 262316004011 DNA binding site [nucleotide binding] 262316004012 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 262316004013 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 262316004014 active site 262316004015 HIGH motif; other site 262316004016 dimer interface [polypeptide binding]; other site 262316004017 KMSKS motif; other site 262316004018 S4 RNA-binding domain; Region: S4; smart00363 262316004019 RNA binding surface [nucleotide binding]; other site 262316004020 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316004021 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 262316004022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316004023 active site 262316004024 motif I; other site 262316004025 motif II; other site 262316004026 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 262316004027 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 262316004028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262316004029 RNA binding surface [nucleotide binding]; other site 262316004030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316004031 S-adenosylmethionine binding site [chemical binding]; other site 262316004032 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 262316004033 ATP-NAD kinase; Region: NAD_kinase; pfam01513 262316004034 DNA repair protein RecN; Region: recN; TIGR00634 262316004035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316004036 Walker A/P-loop; other site 262316004037 ATP binding site [chemical binding]; other site 262316004038 Q-loop/lid; other site 262316004039 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 262316004040 ABC transporter signature motif; other site 262316004041 Walker B; other site 262316004042 D-loop; other site 262316004043 H-loop/switch region; other site 262316004044 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 262316004045 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 262316004046 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 262316004047 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 262316004048 CTP synthetase; Validated; Region: pyrG; PRK05380 262316004049 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 262316004050 Catalytic site [active] 262316004051 active site 262316004052 UTP binding site [chemical binding]; other site 262316004053 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 262316004054 active site 262316004055 putative oxyanion hole; other site 262316004056 catalytic triad [active] 262316004057 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 262316004058 dimer interface [polypeptide binding]; other site 262316004059 ADP-ribose binding site [chemical binding]; other site 262316004060 active site 262316004061 nudix motif; other site 262316004062 metal binding site [ion binding]; metal-binding site 262316004063 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 262316004064 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316004065 active site 262316004066 DNA binding site [nucleotide binding] 262316004067 Int/Topo IB signature motif; other site 262316004068 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316004069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262316004070 S-adenosylmethionine binding site [chemical binding]; other site 262316004071 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 262316004072 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 262316004073 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 262316004074 Magnesium ion binding site [ion binding]; other site 262316004075 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 262316004076 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 262316004077 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 262316004078 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262316004079 RNA binding surface [nucleotide binding]; other site 262316004080 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 262316004081 active site 262316004082 cytidylate kinase; Provisional; Region: cmk; PRK00023 262316004083 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 262316004084 CMP-binding site; other site 262316004085 The sites determining sugar specificity; other site 262316004086 GTP-binding protein Der; Reviewed; Region: PRK03003 262316004087 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 262316004088 G1 box; other site 262316004089 GTP/Mg2+ binding site [chemical binding]; other site 262316004090 Switch I region; other site 262316004091 G2 box; other site 262316004092 Switch II region; other site 262316004093 G3 box; other site 262316004094 G4 box; other site 262316004095 G5 box; other site 262316004096 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 262316004097 G1 box; other site 262316004098 GTP/Mg2+ binding site [chemical binding]; other site 262316004099 Switch I region; other site 262316004100 G2 box; other site 262316004101 G3 box; other site 262316004102 Switch II region; other site 262316004103 G4 box; other site 262316004104 G5 box; other site 262316004105 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 262316004106 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 262316004107 MbtH-like protein; Region: MbtH; pfam03621 262316004108 Condensation domain; Region: Condensation; pfam00668 262316004109 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316004110 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316004111 acyl-activating enzyme (AAE) consensus motif; other site 262316004112 AMP binding site [chemical binding]; other site 262316004113 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316004114 Condensation domain; Region: Condensation; pfam00668 262316004115 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 262316004116 Condensation domain; Region: Condensation; pfam00668 262316004117 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316004118 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316004119 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316004120 acyl-activating enzyme (AAE) consensus motif; other site 262316004121 AMP binding site [chemical binding]; other site 262316004122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316004123 S-adenosylmethionine binding site [chemical binding]; other site 262316004124 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316004125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316004126 Condensation domain; Region: Condensation; pfam00668 262316004127 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316004128 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316004129 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316004130 acyl-activating enzyme (AAE) consensus motif; other site 262316004131 AMP binding site [chemical binding]; other site 262316004132 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316004133 Condensation domain; Region: Condensation; pfam00668 262316004134 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316004135 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316004136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316004137 acyl-activating enzyme (AAE) consensus motif; other site 262316004138 AMP binding site [chemical binding]; other site 262316004139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316004140 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 262316004141 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316004142 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316004143 acyl-activating enzyme (AAE) consensus motif; other site 262316004144 AMP binding site [chemical binding]; other site 262316004145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316004146 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 262316004147 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 262316004148 active site 262316004149 dimer interface [polypeptide binding]; other site 262316004150 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 262316004151 Ligand Binding Site [chemical binding]; other site 262316004152 Molecular Tunnel; other site 262316004153 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 262316004154 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262316004155 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316004156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004158 hypothetical protein; Provisional; Region: PRK14059 262316004159 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 262316004160 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 262316004161 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 262316004162 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 262316004163 Multicopper oxidase; Region: Cu-oxidase; pfam00394 262316004164 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 262316004165 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316004166 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316004167 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316004168 Predicted transcriptional regulators [Transcription]; Region: COG1695 262316004169 Transcriptional regulator PadR-like family; Region: PadR; cl17335 262316004170 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316004171 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316004172 active site 262316004173 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 262316004174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316004175 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262316004176 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316004177 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 262316004178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004179 NAD(P) binding site [chemical binding]; other site 262316004180 active site 262316004181 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262316004182 classical (c) SDRs; Region: SDR_c; cd05233 262316004183 NAD(P) binding site [chemical binding]; other site 262316004184 active site 262316004185 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316004186 classical (c) SDRs; Region: SDR_c; cd05233 262316004187 NAD(P) binding site [chemical binding]; other site 262316004188 active site 262316004189 SnoaL-like domain; Region: SnoaL_4; pfam13577 262316004190 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316004191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316004192 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 262316004193 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 262316004194 NAD(P) binding site [chemical binding]; other site 262316004195 homodimer interface [polypeptide binding]; other site 262316004196 active site 262316004197 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 262316004198 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316004199 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316004200 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316004201 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 262316004202 Bacterial transcriptional regulator; Region: IclR; pfam01614 262316004203 hypothetical protein; Validated; Region: PRK07121 262316004204 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004206 active site 262316004207 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316004208 classical (c) SDRs; Region: SDR_c; cd05233 262316004209 NAD(P) binding site [chemical binding]; other site 262316004210 active site 262316004211 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316004212 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316004213 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316004214 classical (c) SDRs; Region: SDR_c; cd05233 262316004215 NAD(P) binding site [chemical binding]; other site 262316004216 active site 262316004217 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316004218 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316004219 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316004220 classical (c) SDRs; Region: SDR_c; cd05233 262316004221 NAD(P) binding site [chemical binding]; other site 262316004222 active site 262316004223 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316004224 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316004225 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316004226 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316004227 phosphopeptide binding site; other site 262316004228 YppG-like protein; Region: YppG; pfam14179 262316004229 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316004230 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316004231 phosphopeptide binding site; other site 262316004232 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 262316004233 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316004234 Walker A/P-loop; other site 262316004235 ATP binding site [chemical binding]; other site 262316004236 Q-loop/lid; other site 262316004237 ABC transporter signature motif; other site 262316004238 Walker B; other site 262316004239 D-loop; other site 262316004240 H-loop/switch region; other site 262316004241 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 262316004242 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 262316004243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004245 active site 262316004246 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004247 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004248 active site 262316004249 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316004250 active site 262316004251 catalytic site [active] 262316004252 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316004253 putative active site [active] 262316004254 putative catalytic site [active] 262316004255 thiolase; Provisional; Region: PRK06158 262316004256 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316004257 active site 262316004258 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316004259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316004260 acyl-CoA synthetase; Provisional; Region: PRK13388 262316004261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316004262 acyl-activating enzyme (AAE) consensus motif; other site 262316004263 AMP binding site [chemical binding]; other site 262316004264 active site 262316004265 CoA binding site [chemical binding]; other site 262316004266 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316004267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316004268 active site 262316004269 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316004270 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316004271 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 262316004272 active site 262316004273 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316004274 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316004275 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 262316004276 active site 262316004277 short chain dehydrogenase; Provisional; Region: PRK05854 262316004278 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316004279 putative NAD(P) binding site [chemical binding]; other site 262316004280 active site 262316004281 Cytochrome P450; Region: p450; cl12078 262316004282 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316004283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004284 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 262316004285 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 262316004286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316004287 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316004288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316004289 DNA binding residues [nucleotide binding] 262316004290 classical (c) SDRs; Region: SDR_c; cd05233 262316004291 NAD(P) binding site [chemical binding]; other site 262316004292 active site 262316004293 Cutinase; Region: Cutinase; pfam01083 262316004294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004296 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316004297 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316004298 active site 262316004299 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316004300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316004303 S-adenosylmethionine binding site [chemical binding]; other site 262316004304 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 262316004305 DEAD-like helicases superfamily; Region: DEXDc; smart00487 262316004306 ATP binding site [chemical binding]; other site 262316004307 Mg++ binding site [ion binding]; other site 262316004308 motif III; other site 262316004309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316004310 nucleotide binding region [chemical binding]; other site 262316004311 ATP-binding site [chemical binding]; other site 262316004312 enoyl-CoA hydratase; Provisional; Region: PRK06190 262316004313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316004314 substrate binding site [chemical binding]; other site 262316004315 oxyanion hole (OAH) forming residues; other site 262316004316 trimer interface [polypeptide binding]; other site 262316004317 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 262316004318 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316004319 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316004320 [2Fe-2S] cluster binding site [ion binding]; other site 262316004321 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 262316004322 putative alpha subunit interface [polypeptide binding]; other site 262316004323 putative active site [active] 262316004324 putative substrate binding site [chemical binding]; other site 262316004325 Fe binding site [ion binding]; other site 262316004326 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316004327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316004328 acyl-activating enzyme (AAE) consensus motif; other site 262316004329 active site 262316004330 AMP binding site [chemical binding]; other site 262316004331 acyl-activating enzyme (AAE) consensus motif; other site 262316004332 CoA binding site [chemical binding]; other site 262316004333 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316004334 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316004335 substrate binding site [chemical binding]; other site 262316004336 oxyanion hole (OAH) forming residues; other site 262316004337 trimer interface [polypeptide binding]; other site 262316004338 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262316004339 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262316004340 alpha subunit interface [polypeptide binding]; other site 262316004341 TPP binding site [chemical binding]; other site 262316004342 heterodimer interface [polypeptide binding]; other site 262316004343 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316004344 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 262316004345 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262316004346 tetramer interface [polypeptide binding]; other site 262316004347 TPP-binding site [chemical binding]; other site 262316004348 heterodimer interface [polypeptide binding]; other site 262316004349 phosphorylation loop region [posttranslational modification] 262316004350 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316004351 classical (c) SDRs; Region: SDR_c; cd05233 262316004352 NAD(P) binding site [chemical binding]; other site 262316004353 active site 262316004354 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316004355 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316004356 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316004357 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 262316004358 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 262316004359 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 262316004360 hydrophobic ligand binding site; other site 262316004361 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 262316004362 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 262316004363 Moco binding site; other site 262316004364 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 262316004365 metal coordination site [ion binding]; other site 262316004366 SnoaL-like domain; Region: SnoaL_4; pfam13577 262316004367 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316004368 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316004369 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 262316004370 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 262316004371 Protein of unknown function (DUF690); Region: DUF690; pfam05108 262316004372 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316004373 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316004374 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316004375 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316004376 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316004377 Cytochrome P450; Region: p450; cl12078 262316004378 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316004379 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004380 PPE family; Region: PPE; pfam00823 262316004381 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004382 PPE family; Region: PPE; pfam00823 262316004383 PE family; Region: PE; pfam00934 262316004384 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 262316004385 EspG family; Region: ESX-1_EspG; pfam14011 262316004386 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 262316004387 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316004388 catalytic residues [active] 262316004389 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 262316004390 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 262316004391 active site 262316004392 catalytic residues [active] 262316004393 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 262316004394 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 262316004395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 262316004396 TPR motif; other site 262316004397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316004398 Walker A motif; other site 262316004399 ATP binding site [chemical binding]; other site 262316004400 Walker B motif; other site 262316004401 arginine finger; other site 262316004402 PE family; Region: PE; pfam00934 262316004403 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004404 PPE family; Region: PPE; pfam00823 262316004405 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316004406 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004407 PPE family; Region: PPE; pfam00823 262316004408 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316004409 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316004410 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004411 PPE family; Region: PPE; pfam00823 262316004412 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316004413 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004414 PPE family; Region: PPE; pfam00823 262316004415 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316004416 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316004417 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004418 PPE family; Region: PPE; pfam00823 262316004419 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316004420 PPE family; Region: PPE; pfam00823 262316004421 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316004422 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316004423 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 262316004424 MgtC family; Region: MgtC; pfam02308 262316004425 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 262316004426 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 262316004427 Domain of unknown function (DUF385); Region: DUF385; cl04387 262316004428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004429 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 262316004430 active site 262316004431 hypothetical protein; Validated; Region: PRK07121 262316004432 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262316004433 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 262316004434 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 262316004435 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 262316004436 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316004437 PYR/PP interface [polypeptide binding]; other site 262316004438 dimer interface [polypeptide binding]; other site 262316004439 TPP binding site [chemical binding]; other site 262316004440 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316004441 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 262316004442 TPP-binding site; other site 262316004443 dimer interface [polypeptide binding]; other site 262316004444 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 262316004445 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 262316004446 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 262316004447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 262316004448 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 262316004449 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 262316004450 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 262316004451 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 262316004452 lipoyl attachment site [posttranslational modification]; other site 262316004453 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316004454 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316004455 phosphopeptide binding site; other site 262316004456 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 262316004457 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316004458 DNA binding residues [nucleotide binding] 262316004459 Bifunctional nuclease; Region: DNase-RNase; pfam02577 262316004460 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 262316004461 DNA binding residues [nucleotide binding] 262316004462 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316004463 putative dimer interface [polypeptide binding]; other site 262316004464 glycine dehydrogenase; Provisional; Region: PRK05367 262316004465 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 262316004466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316004467 tetramer interface [polypeptide binding]; other site 262316004468 catalytic residue [active] 262316004469 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 262316004470 tetramer interface [polypeptide binding]; other site 262316004471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316004472 catalytic residue [active] 262316004473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004475 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 262316004476 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 262316004477 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316004478 metal ion-dependent adhesion site (MIDAS); other site 262316004479 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 262316004480 active site 262316004481 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262316004482 Domain of unknown function DUF21; Region: DUF21; pfam01595 262316004483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262316004484 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262316004485 Domain of unknown function DUF21; Region: DUF21; pfam01595 262316004486 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262316004487 Transporter associated domain; Region: CorC_HlyC; smart01091 262316004488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 262316004489 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004490 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004491 active site 262316004492 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 262316004493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316004494 acyl-activating enzyme (AAE) consensus motif; other site 262316004495 AMP binding site [chemical binding]; other site 262316004496 active site 262316004497 CoA binding site [chemical binding]; other site 262316004498 acyl carrier protein; Validated; Region: PRK05883 262316004499 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 262316004500 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262316004501 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 262316004502 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 262316004503 active site 262316004504 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262316004505 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 262316004506 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 262316004507 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 262316004508 Predicted transcriptional regulator [Transcription]; Region: COG3682 262316004509 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316004510 CoenzymeA binding site [chemical binding]; other site 262316004511 subunit interaction site [polypeptide binding]; other site 262316004512 PHB binding site; other site 262316004513 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316004514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316004515 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316004516 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316004517 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316004518 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316004519 classical (c) SDRs; Region: SDR_c; cd05233 262316004520 NAD(P) binding site [chemical binding]; other site 262316004521 active site 262316004522 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 262316004523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 262316004524 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 262316004525 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 262316004526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316004527 putative PBP binding loops; other site 262316004528 ABC-ATPase subunit interface; other site 262316004529 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 262316004530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316004531 Walker A/P-loop; other site 262316004532 ATP binding site [chemical binding]; other site 262316004533 Q-loop/lid; other site 262316004534 ABC transporter signature motif; other site 262316004535 Walker B; other site 262316004536 D-loop; other site 262316004537 H-loop/switch region; other site 262316004538 TOBE domain; Region: TOBE; cl01440 262316004539 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 262316004540 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 262316004541 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 262316004542 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 262316004543 putative NAD(P) binding site [chemical binding]; other site 262316004544 putative substrate binding site [chemical binding]; other site 262316004545 catalytic Zn binding site [ion binding]; other site 262316004546 structural Zn binding site [ion binding]; other site 262316004547 CAAX protease self-immunity; Region: Abi; pfam02517 262316004548 putative phosphoketolase; Provisional; Region: PRK05261 262316004549 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 262316004550 TPP-binding site; other site 262316004551 XFP C-terminal domain; Region: XFP_C; pfam09363 262316004552 short chain dehydrogenase; Provisional; Region: PRK07825 262316004553 classical (c) SDRs; Region: SDR_c; cd05233 262316004554 NAD(P) binding site [chemical binding]; other site 262316004555 active site 262316004556 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 262316004557 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316004558 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316004559 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316004560 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316004561 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 262316004562 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316004563 active site 262316004564 hypothetical protein; Provisional; Region: PRK12320 262316004565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004566 NAD(P) binding site [chemical binding]; other site 262316004567 active site 262316004568 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 262316004569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316004570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316004571 Protein of unknown function DUF72; Region: DUF72; pfam01904 262316004572 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 262316004573 helix-hairpin-helix signature motif; other site 262316004574 Domain of unknown function (DUF385); Region: DUF385; pfam04075 262316004575 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 262316004576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316004577 Walker A motif; other site 262316004578 ATP binding site [chemical binding]; other site 262316004579 Walker B motif; other site 262316004580 arginine finger; other site 262316004581 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262316004582 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 262316004583 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 262316004584 active site 262316004585 substrate binding site [chemical binding]; other site 262316004586 FMN binding site [chemical binding]; other site 262316004587 putative catalytic residues [active] 262316004588 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 262316004589 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 262316004590 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 262316004591 active site 262316004592 catalytic site [active] 262316004593 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 262316004594 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316004595 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 262316004596 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 262316004597 dimer interface [polypeptide binding]; other site 262316004598 decamer (pentamer of dimers) interface [polypeptide binding]; other site 262316004599 catalytic triad [active] 262316004600 peroxidatic and resolving cysteines [active] 262316004601 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 262316004602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316004603 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 262316004604 dimerization interface [polypeptide binding]; other site 262316004605 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 262316004606 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316004607 substrate binding site [chemical binding]; other site 262316004608 oxyanion hole (OAH) forming residues; other site 262316004609 trimer interface [polypeptide binding]; other site 262316004610 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 262316004611 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 262316004612 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 262316004613 heme binding site [chemical binding]; other site 262316004614 ferroxidase pore; other site 262316004615 ferroxidase diiron center [ion binding]; other site 262316004616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004617 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316004618 putative substrate translocation pore; other site 262316004619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004620 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316004621 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316004622 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 262316004623 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 262316004624 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 262316004625 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316004626 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316004627 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316004628 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316004629 Cytochrome P450; Region: p450; cl12078 262316004630 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 262316004631 short chain dehydrogenase; Provisional; Region: PRK08267 262316004632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004633 NAD(P) binding site [chemical binding]; other site 262316004634 active site 262316004635 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316004636 hydrophobic ligand binding site; other site 262316004637 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 262316004638 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262316004639 catalytic residue [active] 262316004640 chorismate mutase; Provisional; Region: PRK09269 262316004641 Chorismate mutase type II; Region: CM_2; cl00693 262316004642 Putative esterase; Region: Esterase; pfam00756 262316004643 YceI-like domain; Region: YceI; smart00867 262316004644 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 262316004645 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 262316004646 putative NAD(P) binding site [chemical binding]; other site 262316004647 putative substrate binding site [chemical binding]; other site 262316004648 catalytic Zn binding site [ion binding]; other site 262316004649 structural Zn binding site [ion binding]; other site 262316004650 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316004651 Cytochrome P450; Region: p450; cl12078 262316004652 Nitronate monooxygenase; Region: NMO; pfam03060 262316004653 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262316004654 FMN binding site [chemical binding]; other site 262316004655 substrate binding site [chemical binding]; other site 262316004656 putative catalytic residue [active] 262316004657 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316004658 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316004659 active site 262316004660 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316004661 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316004662 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 262316004663 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316004664 NAD(P) binding site [chemical binding]; other site 262316004665 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316004666 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316004667 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 262316004668 putative active site [active] 262316004669 dimerization interface [polypeptide binding]; other site 262316004670 putative tRNAtyr binding site [nucleotide binding]; other site 262316004671 Domain of unknown function DUF77; Region: DUF77; cl00307 262316004672 competence damage-inducible protein A; Provisional; Region: PRK00549 262316004673 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 262316004674 putative MPT binding site; other site 262316004675 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 262316004676 putative sialic acid transporter; Region: 2A0112; TIGR00891 262316004677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004678 putative substrate translocation pore; other site 262316004679 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316004680 Predicted membrane protein [Function unknown]; Region: COG1950 262316004681 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262316004682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316004685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316004687 DoxX-like family; Region: DoxX_2; pfam13564 262316004688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316004689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316004690 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 262316004691 putative dimerization interface [polypeptide binding]; other site 262316004692 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 262316004693 Flavoprotein; Region: Flavoprotein; pfam02441 262316004694 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 262316004695 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 262316004696 substrate binding site [chemical binding]; other site 262316004697 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316004698 putative hydrophobic ligand binding site [chemical binding]; other site 262316004699 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 262316004700 putative hydrophobic ligand binding site [chemical binding]; other site 262316004701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316004702 dimerization interface [polypeptide binding]; other site 262316004703 putative DNA binding site [nucleotide binding]; other site 262316004704 putative Zn2+ binding site [ion binding]; other site 262316004705 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316004706 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316004707 tetramer interface [polypeptide binding]; other site 262316004708 active site 262316004709 Mg2+/Mn2+ binding site [ion binding]; other site 262316004710 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 262316004711 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 262316004712 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 262316004713 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 262316004714 putative hydrophobic ligand binding site [chemical binding]; other site 262316004715 protein interface [polypeptide binding]; other site 262316004716 gate; other site 262316004717 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 262316004718 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316004719 acyl-activating enzyme (AAE) consensus motif; other site 262316004720 active site 262316004721 short chain dehydrogenase; Provisional; Region: PRK05867 262316004722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316004723 NAD(P) binding site [chemical binding]; other site 262316004724 active site 262316004725 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316004726 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 262316004727 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 262316004728 conserved cys residue [active] 262316004729 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 262316004730 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 262316004731 conserved cys residue [active] 262316004732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316004733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316004734 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 262316004735 dimer interface [polypeptide binding]; other site 262316004736 catalytic triad [active] 262316004737 peroxidatic and resolving cysteines [active] 262316004738 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 262316004739 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262316004740 FMN binding site [chemical binding]; other site 262316004741 substrate binding site [chemical binding]; other site 262316004742 putative catalytic residue [active] 262316004743 YacP-like NYN domain; Region: NYN_YacP; cl01491 262316004744 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004746 active site 262316004747 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 262316004748 extended (e) SDRs; Region: SDR_e; cd08946 262316004749 NAD(P) binding site [chemical binding]; other site 262316004750 active site 262316004751 substrate binding site [chemical binding]; other site 262316004752 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316004753 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316004754 NAD(P) binding site [chemical binding]; other site 262316004755 catalytic residues [active] 262316004756 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 262316004757 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 262316004758 active site 262316004759 catalytic residues [active] 262316004760 Cutinase; Region: Cutinase; pfam01083 262316004761 Methyltransferase domain; Region: Methyltransf_24; pfam13578 262316004762 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 262316004763 Protein of unknown function, DUF608; Region: DUF608; pfam04685 262316004764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316004765 S-adenosylmethionine binding site [chemical binding]; other site 262316004766 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316004767 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316004768 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 262316004769 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 262316004770 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 262316004771 dimer interface [polypeptide binding]; other site 262316004772 active site 262316004773 heme binding site [chemical binding]; other site 262316004774 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 262316004775 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262316004776 metal binding site 2 [ion binding]; metal-binding site 262316004777 putative DNA binding helix; other site 262316004778 metal binding site 1 [ion binding]; metal-binding site 262316004779 dimer interface [polypeptide binding]; other site 262316004780 structural Zn2+ binding site [ion binding]; other site 262316004781 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 262316004782 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 262316004783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316004784 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316004785 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262316004786 hydroxyglutarate oxidase; Provisional; Region: PRK11728 262316004787 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 262316004788 iron-sulfur cluster [ion binding]; other site 262316004789 [2Fe-2S] cluster binding site [ion binding]; other site 262316004790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316004791 S-adenosylmethionine binding site [chemical binding]; other site 262316004792 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316004793 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316004794 homodimer interface [polypeptide binding]; other site 262316004795 active site 262316004796 TDP-binding site; other site 262316004797 acceptor substrate-binding pocket; other site 262316004798 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004799 PPE family; Region: PPE; pfam00823 262316004800 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004801 PPE family; Region: PPE; pfam00823 262316004802 Short C-terminal domain; Region: SHOCT; pfam09851 262316004803 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 262316004804 putative active site [active] 262316004805 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 262316004806 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 262316004807 MOSC domain; Region: MOSC; pfam03473 262316004808 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 262316004809 Cutinase; Region: Cutinase; pfam01083 262316004810 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316004811 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316004812 substrate binding site [chemical binding]; other site 262316004813 oxyanion hole (OAH) forming residues; other site 262316004814 trimer interface [polypeptide binding]; other site 262316004815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262316004816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316004817 metal binding site [ion binding]; metal-binding site 262316004818 active site 262316004819 I-site; other site 262316004820 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 262316004821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316004822 ATP binding site [chemical binding]; other site 262316004823 putative Mg++ binding site [ion binding]; other site 262316004824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316004825 nucleotide binding region [chemical binding]; other site 262316004826 ATP-binding site [chemical binding]; other site 262316004827 Helicase associated domain (HA2); Region: HA2; pfam04408 262316004828 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 262316004829 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 262316004830 hypothetical protein; Provisional; Region: PRK06834 262316004831 hypothetical protein; Provisional; Region: PRK07236 262316004832 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316004833 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 262316004834 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 262316004835 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 262316004836 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 262316004837 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 262316004838 putative oligomer interface [polypeptide binding]; other site 262316004839 putative active site [active] 262316004840 metal binding site [ion binding]; metal-binding site 262316004841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316004842 S-adenosylmethionine binding site [chemical binding]; other site 262316004843 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 262316004844 short chain dehydrogenase; Provisional; Region: PRK06500 262316004845 classical (c) SDRs; Region: SDR_c; cd05233 262316004846 NAD(P) binding site [chemical binding]; other site 262316004847 active site 262316004848 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 262316004849 Condensation domain; Region: Condensation; pfam00668 262316004850 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 262316004851 HSP70 interaction site [polypeptide binding]; other site 262316004852 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 262316004853 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 262316004854 putative dimer interface [polypeptide binding]; other site 262316004855 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 262316004856 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316004857 DNA binding residues [nucleotide binding] 262316004858 putative dimer interface [polypeptide binding]; other site 262316004859 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 262316004860 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 262316004861 putative dimer interface [polypeptide binding]; other site 262316004862 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 262316004863 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 262316004864 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 262316004865 Ligand Binding Site [chemical binding]; other site 262316004866 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316004867 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316004868 biotin carboxylase-like protein; Validated; Region: PRK06524 262316004869 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316004870 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 262316004871 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316004872 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 262316004873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316004874 Helix-turn-helix domain; Region: HTH_18; pfam12833 262316004875 Cellulose binding domain; Region: CBM_2; pfam00553 262316004876 short chain dehydrogenase; Provisional; Region: PRK07577 262316004877 classical (c) SDRs; Region: SDR_c; cd05233 262316004878 NAD(P) binding site [chemical binding]; other site 262316004879 active site 262316004880 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 262316004881 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316004882 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 262316004883 acyl-activating enzyme (AAE) consensus motif; other site 262316004884 putative AMP binding site [chemical binding]; other site 262316004885 putative active site [active] 262316004886 putative CoA binding site [chemical binding]; other site 262316004887 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 262316004888 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 262316004889 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316004890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004892 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316004893 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004895 active site 262316004896 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 262316004897 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316004898 dimer interface [polypeptide binding]; other site 262316004899 active site 262316004900 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 262316004901 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316004902 substrate binding site [chemical binding]; other site 262316004903 oxyanion hole (OAH) forming residues; other site 262316004904 trimer interface [polypeptide binding]; other site 262316004905 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316004906 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262316004907 short chain dehydrogenase; Provisional; Region: PRK07825 262316004908 classical (c) SDRs; Region: SDR_c; cd05233 262316004909 NAD(P) binding site [chemical binding]; other site 262316004910 active site 262316004911 LGFP repeat; Region: LGFP; pfam08310 262316004912 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 262316004913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004915 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 262316004916 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316004917 putative NAD(P) binding site [chemical binding]; other site 262316004918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004920 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316004921 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316004922 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 262316004923 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 262316004924 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 262316004925 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 262316004926 putative heme binding pocket [chemical binding]; other site 262316004927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004929 WHG domain; Region: WHG; pfam13305 262316004930 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 262316004931 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316004932 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316004933 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 262316004934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316004935 motif II; other site 262316004936 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 262316004937 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316004938 active site 262316004939 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316004940 catalytic triad [active] 262316004941 dimer interface [polypeptide binding]; other site 262316004942 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316004943 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 262316004944 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 262316004945 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 262316004946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316004947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316004949 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316004950 PPE family; Region: PPE; pfam00823 262316004951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316004952 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316004953 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316004954 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316004955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316004956 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316004957 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316004958 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 262316004959 homotetramer interface [polypeptide binding]; other site 262316004960 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316004961 NAD binding site [chemical binding]; other site 262316004962 homodimer interface [polypeptide binding]; other site 262316004963 active site 262316004964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316004965 PAS domain; Region: PAS_9; pfam13426 262316004966 putative active site [active] 262316004967 heme pocket [chemical binding]; other site 262316004968 PAS domain S-box; Region: sensory_box; TIGR00229 262316004969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316004970 putative active site [active] 262316004971 heme pocket [chemical binding]; other site 262316004972 Histidine kinase; Region: HisKA_3; pfam07730 262316004973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316004974 Mg2+ binding site [ion binding]; other site 262316004975 G-X-G motif; other site 262316004976 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316004977 Ligand Binding Site [chemical binding]; other site 262316004978 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316004979 Ligand Binding Site [chemical binding]; other site 262316004980 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316004981 Ligand Binding Site [chemical binding]; other site 262316004982 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316004983 dimer interface [polypeptide binding]; other site 262316004984 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 262316004985 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316004986 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316004987 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316004988 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316004989 active site 262316004990 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 262316004991 SnoaL-like domain; Region: SnoaL_4; pfam13577 262316004992 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316004993 extended (e) SDRs; Region: SDR_e; cd08946 262316004994 NAD(P) binding site [chemical binding]; other site 262316004995 active site 262316004996 substrate binding site [chemical binding]; other site 262316004997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316004998 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316004999 active site 262316005000 catalytic tetrad [active] 262316005001 Acyltransferase family; Region: Acyl_transf_3; pfam01757 262316005002 Universal stress protein family; Region: Usp; pfam00582 262316005003 Ligand Binding Site [chemical binding]; other site 262316005004 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316005005 Ligand Binding Site [chemical binding]; other site 262316005006 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 262316005007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316005008 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 262316005009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316005010 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316005011 OsmC-like protein; Region: OsmC; pfam02566 262316005012 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 262316005013 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 262316005014 Imelysin; Region: Peptidase_M75; pfam09375 262316005015 Iron permease FTR1 family; Region: FTR1; cl00475 262316005016 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 262316005017 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 262316005018 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 262316005019 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 262316005020 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 262316005021 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 262316005022 Walker A/P-loop; other site 262316005023 ATP binding site [chemical binding]; other site 262316005024 Q-loop/lid; other site 262316005025 ABC transporter signature motif; other site 262316005026 Walker B; other site 262316005027 D-loop; other site 262316005028 H-loop/switch region; other site 262316005029 TOBE domain; Region: TOBE_2; pfam08402 262316005030 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262316005031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316005032 dimer interface [polypeptide binding]; other site 262316005033 conserved gate region; other site 262316005034 putative PBP binding loops; other site 262316005035 ABC-ATPase subunit interface; other site 262316005036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316005037 dimer interface [polypeptide binding]; other site 262316005038 conserved gate region; other site 262316005039 putative PBP binding loops; other site 262316005040 ABC-ATPase subunit interface; other site 262316005041 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262316005042 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 262316005043 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 262316005044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316005045 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 262316005046 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005047 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005048 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 262316005049 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 262316005050 Isochorismatase family; Region: Isochorismatase; pfam00857 262316005051 catalytic triad [active] 262316005052 conserved cis-peptide bond; other site 262316005053 Predicted membrane protein [Function unknown]; Region: COG2259 262316005054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 262316005055 AAA domain; Region: AAA_33; pfam13671 262316005056 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 262316005057 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 262316005058 Phosphotransferase enzyme family; Region: APH; pfam01636 262316005059 Ecdysteroid kinase; Region: EcKinase; cl17738 262316005060 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 262316005061 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316005062 substrate binding pocket [chemical binding]; other site 262316005063 catalytic triad [active] 262316005064 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316005065 Cytochrome P450; Region: p450; cl12078 262316005066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005067 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005068 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005069 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316005070 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 262316005071 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316005072 classical (c) SDRs; Region: SDR_c; cd05233 262316005073 NAD(P) binding site [chemical binding]; other site 262316005074 active site 262316005075 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316005076 metal ion-dependent adhesion site (MIDAS); other site 262316005077 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 262316005078 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 262316005079 Walker A motif; other site 262316005080 ATP binding site [chemical binding]; other site 262316005081 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 262316005082 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005083 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005084 hypothetical protein; Provisional; Region: PRK05865 262316005085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005086 NAD(P) binding site [chemical binding]; other site 262316005087 active site 262316005088 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 262316005089 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 262316005090 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316005091 active site 262316005092 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316005093 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316005094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005095 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316005096 Enoylreductase; Region: PKS_ER; smart00829 262316005097 NAD(P) binding site [chemical binding]; other site 262316005098 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 262316005099 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 262316005100 putative NADP binding site [chemical binding]; other site 262316005101 active site 262316005102 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316005103 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 262316005104 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316005105 active site 262316005106 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316005107 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316005108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005109 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316005110 Enoylreductase; Region: PKS_ER; smart00829 262316005111 NAD(P) binding site [chemical binding]; other site 262316005112 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 262316005113 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 262316005114 putative NADP binding site [chemical binding]; other site 262316005115 active site 262316005116 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316005117 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 262316005118 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 262316005119 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 262316005120 Ligand binding site; other site 262316005121 Putative Catalytic site; other site 262316005122 DXD motif; other site 262316005123 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 262316005124 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 262316005125 putative active site [active] 262316005126 catalytic triad [active] 262316005127 putative dimer interface [polypeptide binding]; other site 262316005128 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 262316005129 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316005130 active site 262316005131 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 262316005132 Dienelactone hydrolase family; Region: DLH; pfam01738 262316005133 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 262316005134 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 262316005135 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 262316005136 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 262316005137 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 262316005138 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262316005139 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316005140 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 262316005141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262316005142 substrate binding pocket [chemical binding]; other site 262316005143 membrane-bound complex binding site; other site 262316005144 hinge residues; other site 262316005145 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 262316005146 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 262316005147 Walker A/P-loop; other site 262316005148 ATP binding site [chemical binding]; other site 262316005149 Q-loop/lid; other site 262316005150 ABC transporter signature motif; other site 262316005151 Walker B; other site 262316005152 D-loop; other site 262316005153 H-loop/switch region; other site 262316005154 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 262316005155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316005156 dimer interface [polypeptide binding]; other site 262316005157 conserved gate region; other site 262316005158 putative PBP binding loops; other site 262316005159 ABC-ATPase subunit interface; other site 262316005160 precorrin-3B synthase; Region: CobG; TIGR02435 262316005161 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005162 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005163 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 262316005164 Precorrin-8X methylmutase; Region: CbiC; pfam02570 262316005165 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 262316005166 active site 262316005167 SAM binding site [chemical binding]; other site 262316005168 homodimer interface [polypeptide binding]; other site 262316005169 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 262316005170 active site 262316005171 SAM binding site [chemical binding]; other site 262316005172 homodimer interface [polypeptide binding]; other site 262316005173 PPE family; Region: PPE; pfam00823 262316005174 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316005175 Putative zinc-finger; Region: zf-HC2; pfam13490 262316005176 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 262316005177 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 262316005178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316005179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316005180 DNA binding residues [nucleotide binding] 262316005181 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 262316005182 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 262316005183 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 262316005184 active site 262316005185 SAM binding site [chemical binding]; other site 262316005186 homodimer interface [polypeptide binding]; other site 262316005187 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 262316005188 active site 262316005189 putative homodimer interface [polypeptide binding]; other site 262316005190 SAM binding site [chemical binding]; other site 262316005191 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 262316005192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262316005193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005194 classical (c) SDRs; Region: SDR_c; cd05233 262316005195 NAD(P) binding site [chemical binding]; other site 262316005196 active site 262316005197 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 262316005198 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 262316005199 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262316005200 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262316005201 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 262316005202 active site 262316005203 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316005204 Helix-turn-helix domain; Region: HTH_38; pfam13936 262316005205 DNA-binding interface [nucleotide binding]; DNA binding site 262316005206 Integrase core domain; Region: rve; pfam00665 262316005207 5'-3' exonuclease; Region: 53EXOc; smart00475 262316005208 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 262316005209 active site 262316005210 metal binding site 1 [ion binding]; metal-binding site 262316005211 putative 5' ssDNA interaction site; other site 262316005212 metal binding site 3; metal-binding site 262316005213 metal binding site 2 [ion binding]; metal-binding site 262316005214 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 262316005215 putative DNA binding site [nucleotide binding]; other site 262316005216 putative metal binding site [ion binding]; other site 262316005217 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 262316005218 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 262316005219 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 262316005220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316005221 ATP binding site [chemical binding]; other site 262316005222 putative Mg++ binding site [ion binding]; other site 262316005223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316005224 nucleotide binding region [chemical binding]; other site 262316005225 ATP-binding site [chemical binding]; other site 262316005226 Predicted transcriptional regulator [Transcription]; Region: COG3432 262316005227 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 262316005228 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 262316005229 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 262316005230 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 262316005231 Predicted transcriptional regulator [Transcription]; Region: COG2378 262316005232 WYL domain; Region: WYL; pfam13280 262316005233 Predicted transcriptional regulator [Transcription]; Region: COG2378 262316005234 WYL domain; Region: WYL; pfam13280 262316005235 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 262316005236 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 262316005237 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 262316005238 active site 262316005239 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 262316005240 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 262316005241 active site 262316005242 Pup-like protein; Region: Pup; pfam05639 262316005243 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 262316005244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 262316005245 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 262316005246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316005247 S-adenosylmethionine binding site [chemical binding]; other site 262316005248 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 262316005249 mercuric reductase; Validated; Region: PRK06370 262316005250 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316005251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316005252 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316005253 Predicted membrane protein [Function unknown]; Region: COG3918 262316005254 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 262316005255 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 262316005256 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 262316005257 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 262316005258 homodimer interface [polypeptide binding]; other site 262316005259 putative metal binding site [ion binding]; other site 262316005260 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316005261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005262 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316005263 Permease; Region: Permease; pfam02405 262316005264 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316005265 Permease; Region: Permease; pfam02405 262316005266 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 262316005267 mce related protein; Region: MCE; pfam02470 262316005268 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316005269 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005270 mce related protein; Region: MCE; pfam02470 262316005271 mce related protein; Region: MCE; pfam02470 262316005272 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005273 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005274 mce related protein; Region: MCE; pfam02470 262316005275 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005276 mce related protein; Region: MCE; pfam02470 262316005277 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005278 mce related protein; Region: MCE; pfam02470 262316005279 Mannan-binding protein; Region: MVL; pfam12151 262316005280 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 262316005281 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 262316005282 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 262316005283 substrate binding pocket [chemical binding]; other site 262316005284 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 262316005285 B12 binding site [chemical binding]; other site 262316005286 cobalt ligand [ion binding]; other site 262316005287 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 262316005288 PAC2 family; Region: PAC2; pfam09754 262316005289 short chain dehydrogenase; Provisional; Region: PRK05872 262316005290 classical (c) SDRs; Region: SDR_c; cd05233 262316005291 NAD(P) binding site [chemical binding]; other site 262316005292 active site 262316005293 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316005294 active site 262316005295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316005296 acyl-activating enzyme (AAE) consensus motif; other site 262316005297 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 262316005298 FAD binding pocket [chemical binding]; other site 262316005299 FAD binding motif [chemical binding]; other site 262316005300 phosphate binding motif [ion binding]; other site 262316005301 NAD binding pocket [chemical binding]; other site 262316005302 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316005303 Cytochrome P450; Region: p450; cl12078 262316005304 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316005305 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 262316005306 active site 262316005307 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 262316005308 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316005309 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316005310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005311 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316005312 Enoylreductase; Region: PKS_ER; smart00829 262316005313 NAD(P) binding site [chemical binding]; other site 262316005314 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316005315 KR domain; Region: KR; pfam08659 262316005316 putative NADP binding site [chemical binding]; other site 262316005317 active site 262316005318 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316005319 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 262316005320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316005321 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 262316005322 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316005323 AMP binding site [chemical binding]; other site 262316005324 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316005325 Condensation domain; Region: Condensation; pfam00668 262316005326 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316005327 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316005328 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316005329 acyl-activating enzyme (AAE) consensus motif; other site 262316005330 AMP binding site [chemical binding]; other site 262316005331 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316005332 Condensation domain; Region: Condensation; pfam00668 262316005333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316005334 acyl-activating enzyme (AAE) consensus motif; other site 262316005335 MbtH-like protein; Region: MbtH; pfam03621 262316005336 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 262316005337 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316005338 PYR/PP interface [polypeptide binding]; other site 262316005339 dimer interface [polypeptide binding]; other site 262316005340 TPP binding site [chemical binding]; other site 262316005341 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 262316005342 TPP-binding site [chemical binding]; other site 262316005343 AAA ATPase domain; Region: AAA_16; pfam13191 262316005344 AAA domain; Region: AAA_22; pfam13401 262316005345 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316005346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316005347 DNA binding residues [nucleotide binding] 262316005348 dimerization interface [polypeptide binding]; other site 262316005349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316005350 Walker A motif; other site 262316005351 ATP binding site [chemical binding]; other site 262316005352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316005353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316005354 DNA binding residues [nucleotide binding] 262316005355 dimerization interface [polypeptide binding]; other site 262316005356 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316005357 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 262316005358 active site 262316005359 HIGH motif; other site 262316005360 nucleotide binding site [chemical binding]; other site 262316005361 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316005362 active site 262316005363 KMSKS motif; other site 262316005364 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 262316005365 putative tRNA binding surface [nucleotide binding]; other site 262316005366 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 262316005367 active site 262316005368 conserved hypothetical protein; Region: TIGR03843 262316005369 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 262316005370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316005371 catalytic core [active] 262316005372 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 262316005373 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 262316005374 quinone interaction residues [chemical binding]; other site 262316005375 active site 262316005376 catalytic residues [active] 262316005377 FMN binding site [chemical binding]; other site 262316005378 substrate binding site [chemical binding]; other site 262316005379 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316005380 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316005381 active site 262316005382 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 262316005383 substrate binding site [chemical binding]; other site 262316005384 hypothetical protein; Provisional; Region: PRK07906 262316005385 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 262316005386 putative metal binding site [ion binding]; other site 262316005387 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316005388 active site 262316005389 DivIVA domain; Region: DivI1A_domain; TIGR03544 262316005390 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 262316005391 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 262316005392 Predicted integral membrane protein [Function unknown]; Region: COG0762 262316005393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 262316005394 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 262316005395 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316005396 catalytic residue [active] 262316005397 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 262316005398 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 262316005399 cell division protein FtsZ; Validated; Region: PRK09330 262316005400 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 262316005401 nucleotide binding site [chemical binding]; other site 262316005402 SulA interaction site; other site 262316005403 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 262316005404 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262316005405 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316005406 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316005407 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 262316005408 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 262316005409 active site 262316005410 homodimer interface [polypeptide binding]; other site 262316005411 cell division protein FtsW; Region: ftsW; TIGR02614 262316005412 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 262316005413 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316005414 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316005415 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 262316005416 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 262316005417 Mg++ binding site [ion binding]; other site 262316005418 putative catalytic motif [active] 262316005419 putative substrate binding site [chemical binding]; other site 262316005420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316005421 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316005422 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 262316005423 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 262316005424 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 262316005425 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316005426 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 262316005427 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 262316005428 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 262316005429 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 262316005430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316005431 S-adenosylmethionine binding site [chemical binding]; other site 262316005432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 262316005433 MraZ protein; Region: MraZ; pfam02381 262316005434 MraZ protein; Region: MraZ; pfam02381 262316005435 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 262316005436 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 262316005437 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 262316005438 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316005439 substrate binding pocket [chemical binding]; other site 262316005440 chain length determination region; other site 262316005441 substrate-Mg2+ binding site; other site 262316005442 catalytic residues [active] 262316005443 aspartate-rich region 1; other site 262316005444 active site lid residues [active] 262316005445 aspartate-rich region 2; other site 262316005446 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 262316005447 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316005448 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316005449 active site 262316005450 ATP binding site [chemical binding]; other site 262316005451 substrate binding site [chemical binding]; other site 262316005452 activation loop (A-loop); other site 262316005453 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 262316005454 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 262316005455 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 262316005456 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316005457 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316005458 putative acyl-acceptor binding pocket; other site 262316005459 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 262316005460 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 262316005461 DTAP/Switch II; other site 262316005462 Switch I; other site 262316005463 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316005464 putative hydrophobic ligand binding site [chemical binding]; other site 262316005465 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 262316005466 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 262316005467 acyl-activating enzyme (AAE) consensus motif; other site 262316005468 putative AMP binding site [chemical binding]; other site 262316005469 putative active site [active] 262316005470 putative CoA binding site [chemical binding]; other site 262316005471 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316005472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316005473 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 262316005474 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262316005475 NlpC/P60 family; Region: NLPC_P60; pfam00877 262316005476 hypothetical protein; Validated; Region: PRK07883 262316005477 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 262316005478 active site 262316005479 substrate binding site [chemical binding]; other site 262316005480 catalytic site [active] 262316005481 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 262316005482 GIY-YIG motif/motif A; other site 262316005483 active site 262316005484 catalytic site [active] 262316005485 putative DNA binding site [nucleotide binding]; other site 262316005486 metal binding site [ion binding]; metal-binding site 262316005487 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 262316005488 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 262316005489 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 262316005490 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 262316005491 Subunit I/III interface [polypeptide binding]; other site 262316005492 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 262316005493 Cytochrome c; Region: Cytochrom_C; pfam00034 262316005494 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 262316005495 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 262316005496 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 262316005497 iron-sulfur cluster [ion binding]; other site 262316005498 [2Fe-2S] cluster binding site [ion binding]; other site 262316005499 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 262316005500 heme bH binding site [chemical binding]; other site 262316005501 intrachain domain interface; other site 262316005502 heme bL binding site [chemical binding]; other site 262316005503 interchain domain interface [polypeptide binding]; other site 262316005504 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 262316005505 Qo binding site; other site 262316005506 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 262316005507 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316005508 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 262316005509 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 262316005510 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 262316005511 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 262316005512 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 262316005513 dimer interface [polypeptide binding]; other site 262316005514 active site 262316005515 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 262316005516 Ligand Binding Site [chemical binding]; other site 262316005517 Molecular Tunnel; other site 262316005518 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 262316005519 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262316005520 substrate binding site [chemical binding]; other site 262316005521 ATP binding site [chemical binding]; other site 262316005522 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 262316005523 Glycerate kinase family; Region: Gly_kinase; pfam02595 262316005524 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 262316005525 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 262316005526 homotrimer interface [polypeptide binding]; other site 262316005527 Walker A motif; other site 262316005528 GTP binding site [chemical binding]; other site 262316005529 Walker B motif; other site 262316005530 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 262316005531 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 262316005532 putative dimer interface [polypeptide binding]; other site 262316005533 active site pocket [active] 262316005534 putative cataytic base [active] 262316005535 cobalamin synthase; Reviewed; Region: cobS; PRK00235 262316005536 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 262316005537 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 262316005538 homodimer interface [polypeptide binding]; other site 262316005539 substrate-cofactor binding pocket; other site 262316005540 catalytic residue [active] 262316005541 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 262316005542 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 262316005543 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 262316005545 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005546 multifunctional aminopeptidase A; Provisional; Region: PRK00913 262316005547 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 262316005548 interface (dimer of trimers) [polypeptide binding]; other site 262316005549 Substrate-binding/catalytic site; other site 262316005550 Zn-binding sites [ion binding]; other site 262316005551 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316005552 hydrophobic ligand binding site; other site 262316005553 short chain dehydrogenase; Validated; Region: PRK05855 262316005554 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316005555 classical (c) SDRs; Region: SDR_c; cd05233 262316005556 NAD(P) binding site [chemical binding]; other site 262316005557 active site 262316005558 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262316005559 E3 interaction surface; other site 262316005560 lipoyl attachment site [posttranslational modification]; other site 262316005561 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262316005562 E3 interaction surface; other site 262316005563 lipoyl attachment site [posttranslational modification]; other site 262316005564 e3 binding domain; Region: E3_binding; pfam02817 262316005565 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 262316005566 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262316005567 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 262316005568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316005569 NAD(P) binding site [chemical binding]; other site 262316005570 active site 262316005571 lipoate-protein ligase B; Provisional; Region: PRK14345 262316005572 lipoyl synthase; Provisional; Region: PRK05481 262316005573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262316005574 FeS/SAM binding site; other site 262316005575 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 262316005576 RDD family; Region: RDD; pfam06271 262316005577 glutamine synthetase, type I; Region: GlnA; TIGR00653 262316005578 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 262316005579 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316005580 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316005581 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316005582 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316005583 CoenzymeA binding site [chemical binding]; other site 262316005584 subunit interaction site [polypeptide binding]; other site 262316005585 PHB binding site; other site 262316005586 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 262316005587 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 262316005588 metal binding triad; other site 262316005589 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 262316005590 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 262316005591 metal binding triad; other site 262316005592 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 262316005593 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 262316005594 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 262316005595 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316005596 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 262316005597 TAP-like protein; Region: Abhydrolase_4; pfam08386 262316005598 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 262316005599 TAP-like protein; Region: Abhydrolase_4; pfam08386 262316005600 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316005601 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316005602 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 262316005603 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 262316005604 oligomerization interface [polypeptide binding]; other site 262316005605 active site 262316005606 metal binding site [ion binding]; metal-binding site 262316005607 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 262316005608 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 262316005609 putative active site; other site 262316005610 putative metal binding residues [ion binding]; other site 262316005611 signature motif; other site 262316005612 putative triphosphate binding site [ion binding]; other site 262316005613 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 262316005614 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 262316005615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316005616 S-adenosylmethionine binding site [chemical binding]; other site 262316005617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316005618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316005619 sequence-specific DNA binding site [nucleotide binding]; other site 262316005620 salt bridge; other site 262316005621 Cupin domain; Region: Cupin_2; pfam07883 262316005622 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316005623 Cytochrome P450; Region: p450; cl12078 262316005624 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 262316005625 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 262316005626 RNA/DNA hybrid binding site [nucleotide binding]; other site 262316005627 active site 262316005628 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316005629 catalytic core [active] 262316005630 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 262316005631 5' nucleotidase family; Region: 5_nucleotid; cl17687 262316005632 Putative zinc ribbon domain; Region: DUF164; pfam02591 262316005633 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 262316005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 262316005635 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 262316005636 hypothetical protein; Provisional; Region: PRK07908 262316005637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316005638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316005639 homodimer interface [polypeptide binding]; other site 262316005640 catalytic residue [active] 262316005641 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 262316005642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316005643 motif II; other site 262316005644 Low molecular weight phosphatase family; Region: LMWPc; cd00115 262316005645 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 262316005646 active site 262316005647 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 262316005648 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 262316005649 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316005650 Epoxide hydrolase N terminus; Region: EHN; pfam06441 262316005651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316005652 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 262316005653 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 262316005654 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 262316005655 dimer interface [polypeptide binding]; other site 262316005656 catalytic triad [active] 262316005657 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 262316005658 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 262316005659 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 262316005660 dimer interface [polypeptide binding]; other site 262316005661 TPP-binding site [chemical binding]; other site 262316005662 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 262316005663 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 262316005664 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 262316005665 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316005666 acyl carrier protein; Provisional; Region: acpP; PRK00982 262316005667 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 262316005668 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 262316005669 dimer interface [polypeptide binding]; other site 262316005670 active site 262316005671 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 262316005672 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 262316005673 dimer interface [polypeptide binding]; other site 262316005674 active site 262316005675 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262316005676 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316005677 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316005678 FAD binding domain; Region: FAD_binding_3; pfam01494 262316005679 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316005680 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 262316005681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005683 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316005684 FAD binding domain; Region: FAD_binding_4; pfam01565 262316005685 diacylglycerol kinase; Reviewed; Region: PRK11914 262316005686 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 262316005687 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316005688 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316005689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316005690 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262316005691 S-adenosylmethionine binding site [chemical binding]; other site 262316005692 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 262316005693 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316005694 NAD binding site [chemical binding]; other site 262316005695 catalytic Zn binding site [ion binding]; other site 262316005696 substrate binding site [chemical binding]; other site 262316005697 structural Zn binding site [ion binding]; other site 262316005698 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316005699 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 262316005700 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316005701 nucleotide binding site [chemical binding]; other site 262316005702 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316005703 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 262316005704 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316005705 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316005706 Cytochrome P450; Region: p450; cl12078 262316005707 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316005708 Septum formation; Region: Septum_form; pfam13845 262316005709 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316005710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316005711 Cutinase; Region: Cutinase; pfam01083 262316005712 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 262316005713 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262316005714 active site 262316005715 metal binding site [ion binding]; metal-binding site 262316005716 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316005717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316005718 active site 262316005719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005721 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316005722 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316005723 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316005724 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316005725 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316005726 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316005727 active site 262316005728 ATP binding site [chemical binding]; other site 262316005729 substrate binding site [chemical binding]; other site 262316005730 activation loop (A-loop); other site 262316005731 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 262316005732 oligomeric interface; other site 262316005733 putative active site [active] 262316005734 homodimer interface [polypeptide binding]; other site 262316005735 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 262316005736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316005737 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316005738 active site 262316005739 metal binding site [ion binding]; metal-binding site 262316005740 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316005741 Cytochrome P450; Region: p450; cl12078 262316005742 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316005743 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316005744 active site 262316005745 ATP binding site [chemical binding]; other site 262316005746 substrate binding site [chemical binding]; other site 262316005747 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 262316005748 activation loop (A-loop); other site 262316005749 activation loop (A-loop); other site 262316005750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005752 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316005753 Cytochrome P450; Region: p450; cl12078 262316005754 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005755 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005756 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 262316005757 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005758 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316005759 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 262316005760 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 262316005761 Active Sites [active] 262316005762 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 262316005763 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 262316005764 putative active site [active] 262316005765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316005766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316005767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 262316005768 dimerization interface [polypeptide binding]; other site 262316005769 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 262316005770 4Fe-4S binding domain; Region: Fer4; cl02805 262316005771 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 262316005772 HicB family; Region: HicB; pfam05534 262316005773 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316005774 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316005775 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316005776 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 262316005777 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 262316005778 Predicted ATPase [General function prediction only]; Region: COG4637 262316005779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316005780 Walker A/P-loop; other site 262316005781 ATP binding site [chemical binding]; other site 262316005782 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316005783 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 262316005784 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 262316005785 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 262316005786 active site residue [active] 262316005787 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 262316005788 active site residue [active] 262316005789 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316005790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316005791 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005792 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005793 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316005794 Cytochrome P450; Region: p450; cl12078 262316005795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316005796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316005797 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316005798 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 262316005799 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 262316005800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316005801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316005802 homodimer interface [polypeptide binding]; other site 262316005803 catalytic residue [active] 262316005804 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 262316005805 haloalkane dehalogenase; Provisional; Region: PRK00870 262316005806 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 262316005807 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 262316005808 active site 262316005809 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316005810 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 262316005811 dimer interface [polypeptide binding]; other site 262316005812 active site 262316005813 Predicted membrane protein [Function unknown]; Region: COG4270 262316005814 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 262316005815 dimer interface [polypeptide binding]; other site 262316005816 ligand binding site [chemical binding]; other site 262316005817 PknH-like extracellular domain; Region: PknH_C; pfam14032 262316005818 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 262316005819 MgtE intracellular N domain; Region: MgtE_N; smart00924 262316005820 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 262316005821 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 262316005822 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 262316005823 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316005824 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316005825 heat shock protein 90; Provisional; Region: PRK05218 262316005826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316005827 ATP binding site [chemical binding]; other site 262316005828 Mg2+ binding site [ion binding]; other site 262316005829 G-X-G motif; other site 262316005830 TIGR03085 family protein; Region: TIGR03085 262316005831 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 262316005832 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316005833 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 262316005834 acyl-activating enzyme (AAE) consensus motif; other site 262316005835 putative AMP binding site [chemical binding]; other site 262316005836 putative active site [active] 262316005837 putative CoA binding site [chemical binding]; other site 262316005838 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 262316005839 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 262316005840 active site 2 [active] 262316005841 active site 1 [active] 262316005842 CCC1-related family of proteins; Region: CCC1_like; cl00278 262316005843 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262316005844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316005845 S-adenosylmethionine binding site [chemical binding]; other site 262316005846 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316005847 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316005848 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316005849 regulatory phosphorylation site [posttranslational modification]; other site 262316005850 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316005851 GAF domain; Region: GAF_3; pfam13492 262316005852 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 262316005853 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 262316005854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316005855 ATP binding site [chemical binding]; other site 262316005856 Mg2+ binding site [ion binding]; other site 262316005857 G-X-G motif; other site 262316005858 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 262316005859 DNA binding site [nucleotide binding] 262316005860 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 262316005861 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316005862 cyclase homology domain; Region: CHD; cd07302 262316005863 nucleotidyl binding site; other site 262316005864 metal binding site [ion binding]; metal-binding site 262316005865 dimer interface [polypeptide binding]; other site 262316005866 Predicted ATPase [General function prediction only]; Region: COG3899 262316005867 AAA ATPase domain; Region: AAA_16; pfam13191 262316005868 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 262316005869 catalytic triad [active] 262316005870 active site nucleophile [active] 262316005871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316005872 putative substrate translocation pore; other site 262316005873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316005874 putative substrate translocation pore; other site 262316005875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 262316005876 Fructosamine kinase; Region: Fructosamin_kin; cl17579 262316005877 AAA domain; Region: AAA_33; pfam13671 262316005878 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 262316005879 active site 262316005880 Repair protein; Region: Repair_PSII; pfam04536 262316005881 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316005882 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316005883 NAD(P) binding site [chemical binding]; other site 262316005884 catalytic residues [active] 262316005885 PemK-like protein; Region: PemK; pfam02452 262316005886 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316005887 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 262316005888 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 262316005889 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 262316005890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 262316005891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316005892 dimer interface [polypeptide binding]; other site 262316005893 putative PBP binding loops; other site 262316005894 ABC-ATPase subunit interface; other site 262316005895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262316005896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316005897 dimer interface [polypeptide binding]; other site 262316005898 conserved gate region; other site 262316005899 putative PBP binding loops; other site 262316005900 ABC-ATPase subunit interface; other site 262316005901 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262316005902 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 262316005903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262316005904 amino acid transporter; Region: 2A0306; TIGR00909 262316005905 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 262316005906 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 262316005907 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262316005908 inhibitor-cofactor binding pocket; inhibition site 262316005909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316005910 catalytic residue [active] 262316005911 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 262316005912 Amidinotransferase; Region: Amidinotransf; pfam02274 262316005913 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 262316005914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316005915 putative DNA binding site [nucleotide binding]; other site 262316005916 putative Zn2+ binding site [ion binding]; other site 262316005917 AsnC family; Region: AsnC_trans_reg; pfam01037 262316005918 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 262316005919 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 262316005920 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262316005921 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 262316005922 Walker A/P-loop; other site 262316005923 ATP binding site [chemical binding]; other site 262316005924 Q-loop/lid; other site 262316005925 ABC transporter signature motif; other site 262316005926 Walker B; other site 262316005927 D-loop; other site 262316005928 H-loop/switch region; other site 262316005929 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262316005930 Walker A/P-loop; other site 262316005931 ATP binding site [chemical binding]; other site 262316005932 Q-loop/lid; other site 262316005933 ABC transporter signature motif; other site 262316005934 Walker B; other site 262316005935 D-loop; other site 262316005936 H-loop/switch region; other site 262316005937 MarR family; Region: MarR; pfam01047 262316005938 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316005939 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 262316005940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316005941 Walker A/P-loop; other site 262316005942 ATP binding site [chemical binding]; other site 262316005943 Q-loop/lid; other site 262316005944 ABC transporter signature motif; other site 262316005945 Walker B; other site 262316005946 D-loop; other site 262316005947 H-loop/switch region; other site 262316005948 acyl-coenzyme A oxidase; Region: PLN02636 262316005949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316005950 active site 262316005951 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 262316005952 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 262316005953 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 262316005954 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 262316005955 [4Fe-4S] binding site [ion binding]; other site 262316005956 molybdopterin cofactor binding site; other site 262316005957 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 262316005958 molybdopterin cofactor binding site; other site 262316005959 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 262316005960 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262316005961 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 262316005962 FAD binding pocket [chemical binding]; other site 262316005963 FAD binding motif [chemical binding]; other site 262316005964 catalytic residues [active] 262316005965 NAD binding pocket [chemical binding]; other site 262316005966 phosphate binding motif [ion binding]; other site 262316005967 beta-alpha-beta structure motif; other site 262316005968 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 262316005969 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 262316005970 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316005971 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316005972 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005973 mce related protein; Region: MCE; pfam02470 262316005974 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005975 mce related protein; Region: MCE; pfam02470 262316005976 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316005977 mce related protein; Region: MCE; pfam02470 262316005978 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005979 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005980 mce related protein; Region: MCE; pfam02470 262316005981 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 262316005982 dimer interface [polypeptide binding]; other site 262316005983 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005984 mce related protein; Region: MCE; pfam02470 262316005985 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316005986 mce related protein; Region: MCE; pfam02470 262316005987 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316005988 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316005989 Permease; Region: Permease; pfam02405 262316005990 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 262316005991 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 262316005992 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262316005993 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 262316005994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316005995 catalytic residue [active] 262316005996 TQXA domain; Region: TQXA_dom; TIGR03934 262316005997 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 262316005998 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 262316005999 dimer interface [polypeptide binding]; other site 262316006000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316006001 catalytic residue [active] 262316006002 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 262316006003 trimer interface [polypeptide binding]; other site 262316006004 active site 262316006005 substrate binding site [chemical binding]; other site 262316006006 CoA binding site [chemical binding]; other site 262316006007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006008 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316006009 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 262316006010 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 262316006011 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 262316006012 active site 262316006013 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 262316006014 non-prolyl cis peptide bond; other site 262316006015 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 262316006016 Muconolactone delta-isomerase; Region: MIase; cl01992 262316006017 DNA primase; Validated; Region: dnaG; PRK05667 262316006018 CHC2 zinc finger; Region: zf-CHC2; cl17510 262316006019 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 262316006020 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 262316006021 active site 262316006022 metal binding site [ion binding]; metal-binding site 262316006023 interdomain interaction site; other site 262316006024 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 262316006025 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 262316006026 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 262316006027 E-class dimer interface [polypeptide binding]; other site 262316006028 P-class dimer interface [polypeptide binding]; other site 262316006029 active site 262316006030 Cu2+ binding site [ion binding]; other site 262316006031 Zn2+ binding site [ion binding]; other site 262316006032 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 262316006033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262316006034 Zn2+ binding site [ion binding]; other site 262316006035 Mg2+ binding site [ion binding]; other site 262316006036 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 262316006037 Repair protein; Region: Repair_PSII; pfam04536 262316006038 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316006039 PPE family; Region: PPE; pfam00823 262316006040 glycyl-tRNA synthetase; Provisional; Region: PRK04173 262316006041 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316006042 motif 1; other site 262316006043 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 262316006044 active site 262316006045 motif 2; other site 262316006046 motif 3; other site 262316006047 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 262316006048 anticodon binding site; other site 262316006049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316006050 dimerization interface [polypeptide binding]; other site 262316006051 putative DNA binding site [nucleotide binding]; other site 262316006052 putative Zn2+ binding site [ion binding]; other site 262316006053 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262316006054 metal binding site 2 [ion binding]; metal-binding site 262316006055 putative DNA binding helix; other site 262316006056 metal binding site 1 [ion binding]; metal-binding site 262316006057 dimer interface [polypeptide binding]; other site 262316006058 structural Zn2+ binding site [ion binding]; other site 262316006059 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 262316006060 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 262316006061 catalytic residue [active] 262316006062 putative FPP diphosphate binding site; other site 262316006063 putative FPP binding hydrophobic cleft; other site 262316006064 dimer interface [polypeptide binding]; other site 262316006065 putative IPP diphosphate binding site; other site 262316006066 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 262316006067 Recombination protein O N terminal; Region: RecO_N; pfam11967 262316006068 Recombination protein O C terminal; Region: RecO_C; pfam02565 262316006069 amidase; Provisional; Region: PRK06061 262316006070 Amidase; Region: Amidase; pfam01425 262316006071 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 262316006072 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316006073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316006074 catalytic residue [active] 262316006075 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 262316006076 GTPase Era; Reviewed; Region: era; PRK00089 262316006077 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 262316006078 G1 box; other site 262316006079 GTP/Mg2+ binding site [chemical binding]; other site 262316006080 Switch I region; other site 262316006081 G2 box; other site 262316006082 Switch II region; other site 262316006083 G3 box; other site 262316006084 G4 box; other site 262316006085 G5 box; other site 262316006086 KH domain; Region: KH_2; pfam07650 262316006087 Domain of unknown function DUF21; Region: DUF21; pfam01595 262316006088 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262316006089 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262316006090 Transporter associated domain; Region: CorC_HlyC; smart01091 262316006091 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316006092 active site 262316006093 Int/Topo IB signature motif; other site 262316006094 DNA binding site [nucleotide binding] 262316006095 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316006096 MULE transposase domain; Region: MULE; pfam10551 262316006097 Restriction endonuclease; Region: Mrr_cat; pfam04471 262316006098 Transposase; Region: HTH_Tnp_1; cl17663 262316006099 putative transposase OrfB; Reviewed; Region: PHA02517 262316006100 HTH-like domain; Region: HTH_21; pfam13276 262316006101 Integrase core domain; Region: rve; pfam00665 262316006102 Integrase core domain; Region: rve_3; cl15866 262316006103 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316006104 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316006105 metal-binding heat shock protein; Provisional; Region: PRK00016 262316006106 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 262316006107 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 262316006108 PhoH-like protein; Region: PhoH; pfam02562 262316006109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 262316006110 RNA methyltransferase, RsmE family; Region: TIGR00046 262316006111 chaperone protein DnaJ; Provisional; Region: PRK14278 262316006112 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 262316006113 HSP70 interaction site [polypeptide binding]; other site 262316006114 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 262316006115 Zn binding sites [ion binding]; other site 262316006116 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 262316006117 dimer interface [polypeptide binding]; other site 262316006118 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 262316006119 HTH domain; Region: HTH_11; cl17392 262316006120 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 262316006121 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316006122 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316006123 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 262316006124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316006125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 262316006126 MbtH-like protein; Region: MbtH; pfam03621 262316006127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316006128 Condensation domain; Region: Condensation; pfam00668 262316006129 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316006130 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316006131 acyl-activating enzyme (AAE) consensus motif; other site 262316006132 AMP binding site [chemical binding]; other site 262316006133 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316006134 AMP binding site [chemical binding]; other site 262316006135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316006136 Condensation domain; Region: Condensation; pfam00668 262316006137 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316006138 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316006139 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 262316006140 acyl-activating enzyme (AAE) consensus motif; other site 262316006141 AMP binding site [chemical binding]; other site 262316006142 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316006143 Condensation domain; Region: Condensation; pfam00668 262316006144 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316006145 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 262316006146 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006147 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316006148 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 262316006149 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 262316006150 NADP binding site [chemical binding]; other site 262316006151 active site 262316006152 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316006153 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316006154 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316006155 active site 262316006156 Thioesterase domain; Region: Thioesterase; pfam00975 262316006157 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 262316006158 Condensation domain; Region: Condensation; pfam00668 262316006159 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316006160 Nonribosomal peptide synthase; Region: NRPS; pfam08415 262316006161 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 262316006162 acyl-activating enzyme (AAE) consensus motif; other site 262316006163 AMP binding site [chemical binding]; other site 262316006164 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006165 acyl-activating enzyme (AAE) consensus motif; other site 262316006166 CoA binding site [chemical binding]; other site 262316006167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006169 Domain of unknown function (DUF385); Region: DUF385; pfam04075 262316006170 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316006171 Cytochrome P450; Region: p450; cl12078 262316006172 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 262316006173 classical (c) SDRs; Region: SDR_c; cd05233 262316006174 NAD(P) binding site [chemical binding]; other site 262316006175 active site 262316006176 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316006177 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316006178 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316006179 NAD(P) binding site [chemical binding]; other site 262316006180 catalytic residues [active] 262316006181 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 262316006182 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006183 acyl-activating enzyme (AAE) consensus motif; other site 262316006184 AMP binding site [chemical binding]; other site 262316006185 active site 262316006186 CoA binding site [chemical binding]; other site 262316006187 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316006188 mce related protein; Region: MCE; pfam02470 262316006189 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316006190 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316006191 mce related protein; Region: MCE; pfam02470 262316006192 Exo70 exocyst complex subunit; Region: Exo70; pfam03081 262316006193 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316006194 mce related protein; Region: MCE; pfam02470 262316006195 mce related protein; Region: MCE; pfam02470 262316006196 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316006197 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316006198 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316006199 mce related protein; Region: MCE; pfam02470 262316006200 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316006201 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 262316006202 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 262316006203 classical (c) SDRs; Region: SDR_c; cd05233 262316006204 short chain dehydrogenase; Provisional; Region: PRK05650 262316006205 NAD(P) binding site [chemical binding]; other site 262316006206 active site 262316006207 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316006208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316006209 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 262316006210 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316006211 DNA binding residues [nucleotide binding] 262316006212 putative dimer interface [polypeptide binding]; other site 262316006213 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316006214 dinuclear metal binding motif [ion binding]; other site 262316006215 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316006216 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316006217 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316006218 dinuclear metal binding motif [ion binding]; other site 262316006219 salicylate synthase MbtI; Reviewed; Region: PRK07912 262316006220 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 262316006221 Predicted permease [General function prediction only]; Region: COG3329 262316006222 coproporphyrinogen III oxidase; Validated; Region: PRK05628 262316006223 HemN C-terminal domain; Region: HemN_C; pfam06969 262316006224 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 262316006225 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316006226 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316006227 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 262316006228 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 262316006229 Active Sites [active] 262316006230 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 262316006231 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 262316006232 Walker A/P-loop; other site 262316006233 ATP binding site [chemical binding]; other site 262316006234 Q-loop/lid; other site 262316006235 ABC transporter signature motif; other site 262316006236 Walker B; other site 262316006237 D-loop; other site 262316006238 H-loop/switch region; other site 262316006239 TOBE domain; Region: TOBE; pfam03459 262316006240 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 262316006241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316006242 dimer interface [polypeptide binding]; other site 262316006243 conserved gate region; other site 262316006244 putative PBP binding loops; other site 262316006245 ABC-ATPase subunit interface; other site 262316006246 sulfate transport protein; Provisional; Region: cysT; CHL00187 262316006247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316006248 dimer interface [polypeptide binding]; other site 262316006249 conserved gate region; other site 262316006250 putative PBP binding loops; other site 262316006251 ABC-ATPase subunit interface; other site 262316006252 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 262316006253 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 262316006254 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 262316006255 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 262316006256 PknH-like extracellular domain; Region: PknH_C; pfam14032 262316006257 GTP-binding protein LepA; Provisional; Region: PRK05433 262316006258 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 262316006259 G1 box; other site 262316006260 putative GEF interaction site [polypeptide binding]; other site 262316006261 GTP/Mg2+ binding site [chemical binding]; other site 262316006262 Switch I region; other site 262316006263 G2 box; other site 262316006264 G3 box; other site 262316006265 Switch II region; other site 262316006266 G4 box; other site 262316006267 G5 box; other site 262316006268 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 262316006269 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 262316006270 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 262316006271 PemK-like protein; Region: PemK; pfam02452 262316006272 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 262316006273 FOG: CBS domain [General function prediction only]; Region: COG0517 262316006274 ribonuclease Z; Reviewed; Region: PRK00055 262316006275 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 262316006276 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 262316006277 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 262316006278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 262316006279 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 262316006280 Uncharacterized conserved protein [Function unknown]; Region: COG2308 262316006281 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 262316006282 hypothetical protein; Reviewed; Region: PRK07914 262316006283 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 262316006284 Helix-hairpin-helix motif; Region: HHH; pfam00633 262316006285 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 262316006286 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 262316006287 FAD binding site [chemical binding]; other site 262316006288 substrate binding site [chemical binding]; other site 262316006289 catalytic base [active] 262316006290 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 262316006291 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316006292 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316006293 active site 262316006294 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 262316006295 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316006296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316006297 active site 262316006298 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316006299 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316006300 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316006301 KR domain; Region: KR; pfam08659 262316006302 putative NADP binding site [chemical binding]; other site 262316006303 active site 262316006304 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316006305 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316006306 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316006307 active site 262316006308 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316006309 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316006310 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316006311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006312 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316006313 Enoylreductase; Region: PKS_ER; smart00829 262316006314 NAD(P) binding site [chemical binding]; other site 262316006315 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316006316 KR domain; Region: KR; pfam08659 262316006317 putative NADP binding site [chemical binding]; other site 262316006318 active site 262316006319 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316006320 Condensation domain; Region: Condensation; pfam00668 262316006321 MMPL family; Region: MMPL; pfam03176 262316006322 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 262316006323 Transport protein; Region: actII; TIGR00833 262316006324 PE-PPE domain; Region: PE-PPE; pfam08237 262316006325 acyl-CoA synthetase; Validated; Region: PRK05850 262316006326 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316006327 acyl-activating enzyme (AAE) consensus motif; other site 262316006328 active site 262316006329 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 262316006330 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316006331 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 262316006332 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316006333 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316006334 EDD domain protein, DegV family; Region: DegV; TIGR00762 262316006335 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 262316006336 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316006337 catalytic core [active] 262316006338 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 262316006339 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 262316006340 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 262316006341 active site 262316006342 (T/H)XGH motif; other site 262316006343 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 262316006344 NifQ; Region: NifQ; pfam04891 262316006345 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316006346 metal ion-dependent adhesion site (MIDAS); other site 262316006347 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 262316006348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316006349 Walker A motif; other site 262316006350 ATP binding site [chemical binding]; other site 262316006351 Walker B motif; other site 262316006352 arginine finger; other site 262316006353 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 262316006354 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 262316006355 putative catalytic cysteine [active] 262316006356 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 262316006357 Mechanosensitive ion channel; Region: MS_channel; pfam00924 262316006358 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 262316006359 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 262316006360 ligand binding site [chemical binding]; other site 262316006361 flexible hinge region; other site 262316006362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316006363 dimerization interface [polypeptide binding]; other site 262316006364 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 262316006365 cyclase homology domain; Region: CHD; cd07302 262316006366 nucleotidyl binding site; other site 262316006367 metal binding site [ion binding]; metal-binding site 262316006368 dimer interface [polypeptide binding]; other site 262316006369 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262316006370 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 262316006371 substrate binding site [chemical binding]; other site 262316006372 ATP binding site [chemical binding]; other site 262316006373 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262316006374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316006375 DNA-binding site [nucleotide binding]; DNA binding site 262316006376 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 262316006377 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 262316006378 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 262316006379 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316006380 tetramer interface [polypeptide binding]; other site 262316006381 active site 262316006382 Mg2+/Mn2+ binding site [ion binding]; other site 262316006383 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 262316006384 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 262316006385 substrate binding site [chemical binding]; other site 262316006386 ligand binding site [chemical binding]; other site 262316006387 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 262316006388 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 262316006389 substrate binding site [chemical binding]; other site 262316006390 NAD synthetase; Reviewed; Region: nadE; PRK02628 262316006391 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 262316006392 multimer interface [polypeptide binding]; other site 262316006393 active site 262316006394 catalytic triad [active] 262316006395 protein interface 1 [polypeptide binding]; other site 262316006396 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 262316006397 homodimer interface [polypeptide binding]; other site 262316006398 NAD binding pocket [chemical binding]; other site 262316006399 ATP binding pocket [chemical binding]; other site 262316006400 Mg binding site [ion binding]; other site 262316006401 active-site loop [active] 262316006402 Isochorismatase family; Region: Isochorismatase; pfam00857 262316006403 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262316006404 catalytic triad [active] 262316006405 conserved cis-peptide bond; other site 262316006406 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 262316006407 NAD-dependent deacetylase; Provisional; Region: PRK05333 262316006408 NAD+ binding site [chemical binding]; other site 262316006409 substrate binding site [chemical binding]; other site 262316006410 Zn binding site [ion binding]; other site 262316006411 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316006412 Cytochrome P450; Region: p450; cl12078 262316006413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006415 gamma-glutamyl kinase; Provisional; Region: PRK05429 262316006416 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 262316006417 nucleotide binding site [chemical binding]; other site 262316006418 homotetrameric interface [polypeptide binding]; other site 262316006419 putative phosphate binding site [ion binding]; other site 262316006420 putative allosteric binding site; other site 262316006421 PUA domain; Region: PUA; pfam01472 262316006422 GTPase CgtA; Reviewed; Region: obgE; PRK12296 262316006423 GTP1/OBG; Region: GTP1_OBG; pfam01018 262316006424 Obg GTPase; Region: Obg; cd01898 262316006425 G1 box; other site 262316006426 GTP/Mg2+ binding site [chemical binding]; other site 262316006427 Switch I region; other site 262316006428 G2 box; other site 262316006429 G3 box; other site 262316006430 Switch II region; other site 262316006431 G4 box; other site 262316006432 G5 box; other site 262316006433 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 262316006434 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 262316006435 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 262316006436 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 262316006437 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262316006438 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 262316006439 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 262316006440 homodimer interface [polypeptide binding]; other site 262316006441 oligonucleotide binding site [chemical binding]; other site 262316006442 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 262316006443 active site 262316006444 multimer interface [polypeptide binding]; other site 262316006445 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 262316006446 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 262316006447 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 262316006448 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 262316006449 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316006450 active site 262316006451 HIGH motif; other site 262316006452 nucleotide binding site [chemical binding]; other site 262316006453 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 262316006454 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 262316006455 active site 262316006456 KMSKS motif; other site 262316006457 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 262316006458 tRNA binding surface [nucleotide binding]; other site 262316006459 anticodon binding site; other site 262316006460 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 262316006461 Uncharacterized conserved protein [Function unknown]; Region: COG3268 262316006462 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 262316006463 NAD(P) binding pocket [chemical binding]; other site 262316006464 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 262316006465 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316006466 MULE transposase domain; Region: MULE; pfam10551 262316006467 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 262316006468 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 262316006469 GTP binding site; other site 262316006470 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 262316006471 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 262316006472 TPP-binding site [chemical binding]; other site 262316006473 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 262316006474 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 262316006475 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 262316006476 dimer interface [polypeptide binding]; other site 262316006477 PYR/PP interface [polypeptide binding]; other site 262316006478 TPP binding site [chemical binding]; other site 262316006479 substrate binding site [chemical binding]; other site 262316006480 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 262316006481 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 262316006482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316006483 Walker A motif; other site 262316006484 ATP binding site [chemical binding]; other site 262316006485 Walker B motif; other site 262316006486 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 262316006487 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 262316006488 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 262316006489 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 262316006490 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 262316006491 oligomer interface [polypeptide binding]; other site 262316006492 active site residues [active] 262316006493 Clp protease; Region: CLP_protease; pfam00574 262316006494 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 262316006495 oligomer interface [polypeptide binding]; other site 262316006496 active site residues [active] 262316006497 trigger factor; Provisional; Region: tig; PRK01490 262316006498 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 262316006499 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 262316006500 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316006501 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316006502 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 262316006503 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 262316006504 putative DNA binding site [nucleotide binding]; other site 262316006505 catalytic residue [active] 262316006506 putative H2TH interface [polypeptide binding]; other site 262316006507 putative catalytic residues [active] 262316006508 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316006509 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316006510 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 262316006511 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 262316006512 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 262316006513 catalytic residues [active] 262316006514 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 262316006515 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 262316006516 Zn binding site [ion binding]; other site 262316006517 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 262316006518 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316006519 active site 262316006520 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 262316006521 apolar tunnel; other site 262316006522 heme binding site [chemical binding]; other site 262316006523 dimerization interface [polypeptide binding]; other site 262316006524 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 262316006525 active site 262316006526 catalytic site [active] 262316006527 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 262316006528 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 262316006529 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262316006530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262316006531 ABC transporter; Region: ABC_tran_2; pfam12848 262316006532 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262316006533 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 262316006534 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 262316006535 dimer interface [polypeptide binding]; other site 262316006536 ssDNA binding site [nucleotide binding]; other site 262316006537 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262316006538 Copper resistance protein D; Region: CopD; pfam05425 262316006539 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 262316006540 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 262316006541 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 262316006542 putative acyl-acceptor binding pocket; other site 262316006543 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316006544 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 262316006545 putative acyl-acceptor binding pocket; other site 262316006546 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316006547 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316006548 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 262316006549 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316006550 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 262316006551 Winged helix-turn helix; Region: HTH_29; pfam13551 262316006552 DNA-binding interface [nucleotide binding]; DNA binding site 262316006553 Homeodomain-like domain; Region: HTH_32; pfam13565 262316006554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316006555 Integrase core domain; Region: rve; pfam00665 262316006556 Integrase core domain; Region: rve_3; pfam13683 262316006557 Cutinase; Region: Cutinase; pfam01083 262316006558 enoyl-CoA hydratase; Provisional; Region: PRK05870 262316006559 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316006560 substrate binding site [chemical binding]; other site 262316006561 oxyanion hole (OAH) forming residues; other site 262316006562 trimer interface [polypeptide binding]; other site 262316006563 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262316006564 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 262316006565 E3 interaction surface; other site 262316006566 lipoyl attachment site [posttranslational modification]; other site 262316006567 e3 binding domain; Region: E3_binding; pfam02817 262316006568 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262316006569 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262316006570 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262316006571 alpha subunit interface [polypeptide binding]; other site 262316006572 TPP binding site [chemical binding]; other site 262316006573 heterodimer interface [polypeptide binding]; other site 262316006574 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316006575 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 262316006576 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262316006577 tetramer interface [polypeptide binding]; other site 262316006578 TPP-binding site [chemical binding]; other site 262316006579 heterodimer interface [polypeptide binding]; other site 262316006580 phosphorylation loop region [posttranslational modification] 262316006581 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 262316006582 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 262316006583 putative active site [active] 262316006584 putative catalytic site [active] 262316006585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006587 active site 262316006588 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 262316006589 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316006590 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 262316006591 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 262316006592 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262316006593 carboxyltransferase (CT) interaction site; other site 262316006594 biotinylation site [posttranslational modification]; other site 262316006595 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316006596 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262316006597 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316006598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006600 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316006601 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 262316006602 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316006603 classical (c) SDRs; Region: SDR_c; cd05233 262316006604 NAD(P) binding site [chemical binding]; other site 262316006605 active site 262316006606 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 262316006607 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 262316006608 catalytic site [active] 262316006609 putative active site [active] 262316006610 putative substrate binding site [chemical binding]; other site 262316006611 dimer interface [polypeptide binding]; other site 262316006612 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 262316006613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316006614 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 262316006615 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316006616 MMPL family; Region: MMPL; pfam03176 262316006617 MMPL family; Region: MMPL; pfam03176 262316006618 hypothetical protein; Provisional; Region: PRK01346 262316006619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 262316006620 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 262316006621 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 262316006622 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 262316006623 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262316006624 catalytic triad [active] 262316006625 hypothetical protein; Provisional; Region: PRK07907 262316006626 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 262316006627 active site 262316006628 metal binding site [ion binding]; metal-binding site 262316006629 dimer interface [polypeptide binding]; other site 262316006630 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 262316006631 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 262316006632 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 262316006633 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262316006634 phosphate binding site [ion binding]; other site 262316006635 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 262316006636 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 262316006637 putative active site [active] 262316006638 putative catalytic site [active] 262316006639 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 262316006640 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 262316006641 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 262316006642 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 262316006643 putative NAD(P) binding site [chemical binding]; other site 262316006644 active site 262316006645 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 262316006646 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 262316006647 active site 262316006648 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 262316006649 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 262316006650 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316006651 DNA binding residues [nucleotide binding] 262316006652 dimer interface [polypeptide binding]; other site 262316006653 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316006654 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316006655 [2Fe-2S] cluster binding site [ion binding]; other site 262316006656 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 262316006657 putative alpha subunit interface [polypeptide binding]; other site 262316006658 putative active site [active] 262316006659 putative substrate binding site [chemical binding]; other site 262316006660 Fe binding site [ion binding]; other site 262316006661 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 262316006662 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 262316006663 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316006664 NAD binding site [chemical binding]; other site 262316006665 catalytic residues [active] 262316006666 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316006667 putative active site [active] 262316006668 putative catalytic site [active] 262316006669 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316006670 active site 262316006671 catalytic site [active] 262316006672 SnoaL-like domain; Region: SnoaL_4; pfam13577 262316006673 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 262316006674 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 262316006675 acyl-activating enzyme (AAE) consensus motif; other site 262316006676 putative AMP binding site [chemical binding]; other site 262316006677 putative active site [active] 262316006678 putative CoA binding site [chemical binding]; other site 262316006679 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316006680 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316006681 [2Fe-2S] cluster binding site [ion binding]; other site 262316006682 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316006683 hydrophobic ligand binding site; other site 262316006684 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316006685 Cytochrome P450; Region: p450; cl12078 262316006686 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 262316006687 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 262316006688 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316006689 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316006690 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316006691 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316006692 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316006693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316006694 DNA-binding site [nucleotide binding]; DNA binding site 262316006695 FCD domain; Region: FCD; pfam07729 262316006696 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 262316006697 classical (c) SDRs; Region: SDR_c; cd05233 262316006698 NAD(P) binding site [chemical binding]; other site 262316006699 active site 262316006700 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316006701 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006702 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 262316006703 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316006704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006705 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006706 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006707 active site 262316006708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006710 active site 262316006711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006712 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 262316006713 active site 262316006714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006715 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316006716 acyl-activating enzyme (AAE) consensus motif; other site 262316006717 CoA binding site [chemical binding]; other site 262316006718 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006719 AMP binding site [chemical binding]; other site 262316006720 active site 262316006721 CoA binding site [chemical binding]; other site 262316006722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006724 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316006725 CoenzymeA binding site [chemical binding]; other site 262316006726 subunit interaction site [polypeptide binding]; other site 262316006727 PHB binding site; other site 262316006728 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316006729 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 262316006730 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 262316006731 Moco binding site; other site 262316006732 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 262316006733 metal coordination site [ion binding]; other site 262316006734 PAS fold; Region: PAS_4; pfam08448 262316006735 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 262316006736 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 262316006737 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 262316006738 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 262316006739 ATP binding site [chemical binding]; other site 262316006740 Mg2+ binding site [ion binding]; other site 262316006741 G-X-G motif; other site 262316006742 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006743 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006744 active site 262316006745 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006746 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316006747 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316006748 active site 262316006749 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316006750 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316006751 substrate binding pocket [chemical binding]; other site 262316006752 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316006753 Cytochrome P450; Region: p450; cl12078 262316006754 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 262316006755 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316006756 NAD binding site [chemical binding]; other site 262316006757 catalytic Zn binding site [ion binding]; other site 262316006758 substrate binding site [chemical binding]; other site 262316006759 structural Zn binding site [ion binding]; other site 262316006760 Predicted membrane protein [Function unknown]; Region: COG1511 262316006761 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 262316006762 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 262316006763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316006764 Walker A/P-loop; other site 262316006765 ATP binding site [chemical binding]; other site 262316006766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316006767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006768 short chain dehydrogenase; Provisional; Region: PRK06197 262316006769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006770 NAD(P) binding site [chemical binding]; other site 262316006771 active site 262316006772 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316006773 Cytochrome P450; Region: p450; cl12078 262316006774 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316006775 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262316006776 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316006777 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 262316006778 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316006779 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316006780 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316006781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316006782 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 262316006783 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316006784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316006785 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316006786 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316006787 [2Fe-2S] cluster binding site [ion binding]; other site 262316006788 Isochorismatase family; Region: Isochorismatase; pfam00857 262316006789 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262316006790 catalytic triad [active] 262316006791 conserved cis-peptide bond; other site 262316006792 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316006793 CoenzymeA binding site [chemical binding]; other site 262316006794 subunit interaction site [polypeptide binding]; other site 262316006795 PHB binding site; other site 262316006796 acyl-CoA synthetase; Validated; Region: PRK07798 262316006797 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006798 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 262316006799 acyl-activating enzyme (AAE) consensus motif; other site 262316006800 acyl-activating enzyme (AAE) consensus motif; other site 262316006801 putative AMP binding site [chemical binding]; other site 262316006802 putative active site [active] 262316006803 putative CoA binding site [chemical binding]; other site 262316006804 classical (c) SDRs; Region: SDR_c; cd05233 262316006805 NAD(P) binding site [chemical binding]; other site 262316006806 active site 262316006807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316006808 Cytochrome P450; Region: p450; cl12078 262316006809 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316006810 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316006811 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 262316006812 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316006813 active site 262316006814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006816 active site 262316006817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006818 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316006819 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006820 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316006821 acyl-CoA synthetase; Validated; Region: PRK07798 262316006822 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006823 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 262316006824 acyl-activating enzyme (AAE) consensus motif; other site 262316006825 acyl-activating enzyme (AAE) consensus motif; other site 262316006826 putative AMP binding site [chemical binding]; other site 262316006827 putative active site [active] 262316006828 putative CoA binding site [chemical binding]; other site 262316006829 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316006830 enoyl-CoA hydratase; Provisional; Region: PRK06210 262316006831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316006832 substrate binding site [chemical binding]; other site 262316006833 oxyanion hole (OAH) forming residues; other site 262316006834 trimer interface [polypeptide binding]; other site 262316006835 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 262316006836 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 262316006837 active site 262316006838 inhibitor site; inhibition site 262316006839 dimer interface [polypeptide binding]; other site 262316006840 catalytic residue [active] 262316006841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316006843 NAD(P) binding site [chemical binding]; other site 262316006844 active site 262316006845 tetracycline repressor protein TetR; Provisional; Region: PRK13756 262316006846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316006847 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 262316006848 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316006849 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 262316006850 substrate binding site [chemical binding]; other site 262316006851 oxyanion hole (OAH) forming residues; other site 262316006852 trimer interface [polypeptide binding]; other site 262316006853 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316006854 CoenzymeA binding site [chemical binding]; other site 262316006855 subunit interaction site [polypeptide binding]; other site 262316006856 PHB binding site; other site 262316006857 enoyl-CoA hydratase; Provisional; Region: PRK06688 262316006858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316006859 substrate binding site [chemical binding]; other site 262316006860 oxyanion hole (OAH) forming residues; other site 262316006861 trimer interface [polypeptide binding]; other site 262316006862 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316006863 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316006864 substrate binding site [chemical binding]; other site 262316006865 oxyanion hole (OAH) forming residues; other site 262316006866 trimer interface [polypeptide binding]; other site 262316006867 enoyl-CoA hydratase; Provisional; Region: PRK05864 262316006868 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316006869 substrate binding site [chemical binding]; other site 262316006870 oxyanion hole (OAH) forming residues; other site 262316006871 trimer interface [polypeptide binding]; other site 262316006872 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316006873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006874 acyl-activating enzyme (AAE) consensus motif; other site 262316006875 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006876 AMP binding site [chemical binding]; other site 262316006877 active site 262316006878 acyl-activating enzyme (AAE) consensus motif; other site 262316006879 CoA binding site [chemical binding]; other site 262316006880 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316006881 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006882 acyl-activating enzyme (AAE) consensus motif; other site 262316006883 AMP binding site [chemical binding]; other site 262316006884 active site 262316006885 CoA binding site [chemical binding]; other site 262316006886 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316006887 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316006889 acyl-activating enzyme (AAE) consensus motif; other site 262316006890 acyl-activating enzyme (AAE) consensus motif; other site 262316006891 AMP binding site [chemical binding]; other site 262316006892 active site 262316006893 CoA binding site [chemical binding]; other site 262316006894 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316006895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316006896 DNA-binding site [nucleotide binding]; DNA binding site 262316006897 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 262316006898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006899 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006900 active site 262316006901 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 262316006902 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316006903 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 262316006904 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316006905 dimer interface [polypeptide binding]; other site 262316006906 active site 262316006907 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316006908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316006909 NAD(P) binding site [chemical binding]; other site 262316006910 active site 262316006911 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316006912 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316006913 active site 262316006914 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316006915 classical (c) SDRs; Region: SDR_c; cd05233 262316006916 NAD(P) binding site [chemical binding]; other site 262316006917 active site 262316006918 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316006919 Phosphotransferase enzyme family; Region: APH; pfam01636 262316006920 Ecdysteroid kinase; Region: EcKinase; cl17738 262316006921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316006922 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262316006923 Walker A/P-loop; other site 262316006924 ATP binding site [chemical binding]; other site 262316006925 Q-loop/lid; other site 262316006926 ABC transporter signature motif; other site 262316006927 Walker B; other site 262316006928 D-loop; other site 262316006929 H-loop/switch region; other site 262316006930 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 262316006931 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 262316006932 FAD binding pocket [chemical binding]; other site 262316006933 FAD binding motif [chemical binding]; other site 262316006934 phosphate binding motif [ion binding]; other site 262316006935 NAD binding pocket [chemical binding]; other site 262316006936 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316006937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316006938 Walker A/P-loop; other site 262316006939 ATP binding site [chemical binding]; other site 262316006940 Q-loop/lid; other site 262316006941 ABC transporter signature motif; other site 262316006942 Walker B; other site 262316006943 D-loop; other site 262316006944 H-loop/switch region; other site 262316006945 Transposase domain (DUF772); Region: DUF772; pfam05598 262316006946 Glucitol operon activator protein (GutM); Region: GutM; cl01890 262316006947 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 262316006948 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 262316006949 active site 262316006950 dimerization interface [polypeptide binding]; other site 262316006951 Ribonuclease PH; Region: RNase_PH_bact; cd11362 262316006952 ribonuclease PH; Reviewed; Region: rph; PRK00173 262316006953 hexamer interface [polypeptide binding]; other site 262316006954 active site 262316006955 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 262316006956 glutamate racemase; Provisional; Region: PRK00865 262316006957 Rhomboid family; Region: Rhomboid; pfam01694 262316006958 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 262316006959 putative active site pocket [active] 262316006960 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 262316006961 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 262316006962 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 262316006963 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 262316006964 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 262316006965 active site 262316006966 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 262316006967 DEAD/DEAH box helicase; Region: DEAD; pfam00270 262316006968 ATP binding site [chemical binding]; other site 262316006969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316006970 putative Mg++ binding site [ion binding]; other site 262316006971 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 262316006972 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 262316006973 putative homodimer interface [polypeptide binding]; other site 262316006974 putative active site pocket [active] 262316006975 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 262316006976 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 262316006977 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 262316006978 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 262316006979 active site 262316006980 homodimer interface [polypeptide binding]; other site 262316006981 catalytic site [active] 262316006982 acceptor binding site [chemical binding]; other site 262316006983 glycogen branching enzyme; Provisional; Region: PRK05402 262316006984 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 262316006985 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 262316006986 active site 262316006987 catalytic site [active] 262316006988 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 262316006989 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 262316006990 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 262316006991 putative acyltransferase; Provisional; Region: PRK05790 262316006992 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316006993 dimer interface [polypeptide binding]; other site 262316006994 active site 262316006995 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 262316006996 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316006997 dimer interface [polypeptide binding]; other site 262316006998 substrate binding site [chemical binding]; other site 262316006999 metal binding site [ion binding]; metal-binding site 262316007000 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 262316007001 hypothetical protein; Provisional; Region: PRK03298 262316007002 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 262316007003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316007004 dimerization interface [polypeptide binding]; other site 262316007005 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316007006 cyclase homology domain; Region: CHD; cd07302 262316007007 nucleotidyl binding site; other site 262316007008 metal binding site [ion binding]; metal-binding site 262316007009 dimer interface [polypeptide binding]; other site 262316007010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316007011 putative substrate translocation pore; other site 262316007012 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 262316007013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316007014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316007015 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 262316007016 putative dimerization interface [polypeptide binding]; other site 262316007017 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 262316007018 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 262316007019 AlkA N-terminal domain; Region: AlkA_N; pfam06029 262316007020 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 262316007021 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316007022 minor groove reading motif; other site 262316007023 helix-hairpin-helix signature motif; other site 262316007024 substrate binding pocket [chemical binding]; other site 262316007025 active site 262316007026 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316007027 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316007028 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 262316007029 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 262316007030 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262316007031 DNA binding site [nucleotide binding] 262316007032 active site 262316007033 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 262316007034 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 262316007035 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 262316007036 hinge; other site 262316007037 active site 262316007038 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 262316007039 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 262316007040 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 262316007041 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 262316007042 gamma subunit interface [polypeptide binding]; other site 262316007043 epsilon subunit interface [polypeptide binding]; other site 262316007044 LBP interface [polypeptide binding]; other site 262316007045 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 262316007046 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 262316007047 alpha subunit interaction interface [polypeptide binding]; other site 262316007048 Walker A motif; other site 262316007049 ATP binding site [chemical binding]; other site 262316007050 Walker B motif; other site 262316007051 inhibitor binding site; inhibition site 262316007052 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262316007053 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 262316007054 core domain interface [polypeptide binding]; other site 262316007055 delta subunit interface [polypeptide binding]; other site 262316007056 epsilon subunit interface [polypeptide binding]; other site 262316007057 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 262316007058 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 262316007059 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 262316007060 beta subunit interaction interface [polypeptide binding]; other site 262316007061 Walker A motif; other site 262316007062 ATP binding site [chemical binding]; other site 262316007063 Walker B motif; other site 262316007064 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262316007065 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 262316007066 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 262316007067 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 262316007068 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 262316007069 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 262316007070 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 262316007071 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 262316007072 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 262316007073 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 262316007074 Mg++ binding site [ion binding]; other site 262316007075 putative catalytic motif [active] 262316007076 substrate binding site [chemical binding]; other site 262316007077 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 262316007078 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 262316007079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316007080 S-adenosylmethionine binding site [chemical binding]; other site 262316007081 peptide chain release factor 1; Validated; Region: prfA; PRK00591 262316007082 This domain is found in peptide chain release factors; Region: PCRF; smart00937 262316007083 RF-1 domain; Region: RF-1; pfam00472 262316007084 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 262316007085 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 262316007086 transcription termination factor Rho; Provisional; Region: PRK12608 262316007087 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 262316007088 RNA binding site [nucleotide binding]; other site 262316007089 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 262316007090 multimer interface [polypeptide binding]; other site 262316007091 Walker A motif; other site 262316007092 ATP binding site [chemical binding]; other site 262316007093 Walker B motif; other site 262316007094 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 262316007095 threonine synthase; Reviewed; Region: PRK06721 262316007096 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 262316007097 homodimer interface [polypeptide binding]; other site 262316007098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316007099 catalytic residue [active] 262316007100 homoserine dehydrogenase; Provisional; Region: PRK06349 262316007101 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 262316007102 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 262316007103 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 262316007104 diaminopimelate decarboxylase; Region: lysA; TIGR01048 262316007105 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 262316007106 active site 262316007107 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316007108 substrate binding site [chemical binding]; other site 262316007109 catalytic residues [active] 262316007110 dimer interface [polypeptide binding]; other site 262316007111 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 262316007112 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 262316007113 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 262316007114 active site 262316007115 HIGH motif; other site 262316007116 KMSK motif region; other site 262316007117 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 262316007118 tRNA binding surface [nucleotide binding]; other site 262316007119 anticodon binding site; other site 262316007120 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 262316007121 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316007122 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 262316007123 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 262316007124 dimer interface [polypeptide binding]; other site 262316007125 ADP-ribose binding site [chemical binding]; other site 262316007126 active site 262316007127 nudix motif; other site 262316007128 metal binding site [ion binding]; metal-binding site 262316007129 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316007130 TrkA-N domain; Region: TrkA_N; pfam02254 262316007131 Ion channel; Region: Ion_trans_2; pfam07885 262316007132 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 262316007133 TrkA-N domain; Region: TrkA_N; pfam02254 262316007134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 262316007135 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316007136 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 262316007137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316007138 metal binding site [ion binding]; metal-binding site 262316007139 Rrf2 family protein; Region: rrf2_super; TIGR00738 262316007140 Transcriptional regulator; Region: Rrf2; pfam02082 262316007141 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 262316007142 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 262316007143 G1 box; other site 262316007144 putative GEF interaction site [polypeptide binding]; other site 262316007145 GTP/Mg2+ binding site [chemical binding]; other site 262316007146 Switch I region; other site 262316007147 G2 box; other site 262316007148 CysD dimerization site [polypeptide binding]; other site 262316007149 G3 box; other site 262316007150 Switch II region; other site 262316007151 G4 box; other site 262316007152 G5 box; other site 262316007153 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 262316007154 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 262316007155 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 262316007156 ligand-binding site [chemical binding]; other site 262316007157 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 262316007158 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 262316007159 Active Sites [active] 262316007160 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316007161 CoenzymeA binding site [chemical binding]; other site 262316007162 subunit interaction site [polypeptide binding]; other site 262316007163 PHB binding site; other site 262316007164 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 262316007165 active site clefts [active] 262316007166 zinc binding site [ion binding]; other site 262316007167 dimer interface [polypeptide binding]; other site 262316007168 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262316007169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316007170 dimer interface [polypeptide binding]; other site 262316007171 conserved gate region; other site 262316007172 putative PBP binding loops; other site 262316007173 ABC-ATPase subunit interface; other site 262316007174 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 262316007175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316007176 dimer interface [polypeptide binding]; other site 262316007177 conserved gate region; other site 262316007178 putative PBP binding loops; other site 262316007179 ABC-ATPase subunit interface; other site 262316007180 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 262316007181 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262316007182 Walker A/P-loop; other site 262316007183 ATP binding site [chemical binding]; other site 262316007184 Q-loop/lid; other site 262316007185 ABC transporter signature motif; other site 262316007186 Walker B; other site 262316007187 D-loop; other site 262316007188 H-loop/switch region; other site 262316007189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316007190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262316007191 Walker A/P-loop; other site 262316007192 ATP binding site [chemical binding]; other site 262316007193 Q-loop/lid; other site 262316007194 ABC transporter signature motif; other site 262316007195 Walker B; other site 262316007196 D-loop; other site 262316007197 H-loop/switch region; other site 262316007198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262316007199 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 262316007200 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 262316007201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316007202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316007203 Walker A/P-loop; other site 262316007204 ATP binding site [chemical binding]; other site 262316007205 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 262316007206 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 262316007207 active site 262316007208 metal binding site [ion binding]; metal-binding site 262316007209 DNA binding site [nucleotide binding] 262316007210 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316007211 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316007212 active site 262316007213 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316007214 catalytic core [active] 262316007215 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 262316007216 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 262316007217 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262316007218 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262316007219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316007220 Walker A/P-loop; other site 262316007221 ATP binding site [chemical binding]; other site 262316007222 Q-loop/lid; other site 262316007223 ABC transporter signature motif; other site 262316007224 Walker B; other site 262316007225 D-loop; other site 262316007226 H-loop/switch region; other site 262316007227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262316007228 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 262316007229 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 262316007230 Walker A/P-loop; other site 262316007231 ATP binding site [chemical binding]; other site 262316007232 Q-loop/lid; other site 262316007233 ABC transporter signature motif; other site 262316007234 Walker B; other site 262316007235 D-loop; other site 262316007236 H-loop/switch region; other site 262316007237 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316007238 Transposase domain (DUF772); Region: DUF772; pfam05598 262316007239 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 262316007240 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 262316007241 DNA binding site [nucleotide binding] 262316007242 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316007243 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316007244 phosphopeptide binding site; other site 262316007245 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316007246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316007247 active site 262316007248 ATP binding site [chemical binding]; other site 262316007249 substrate binding site [chemical binding]; other site 262316007250 activation loop (A-loop); other site 262316007251 PknH-like extracellular domain; Region: PknH_C; pfam14032 262316007252 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316007253 cyclase homology domain; Region: CHD; cd07302 262316007254 nucleotidyl binding site; other site 262316007255 metal binding site [ion binding]; metal-binding site 262316007256 dimer interface [polypeptide binding]; other site 262316007257 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 262316007258 putative active site [active] 262316007259 amidase; Provisional; Region: PRK12470 262316007260 Amidase; Region: Amidase; cl11426 262316007261 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 262316007262 HIT family signature motif; other site 262316007263 catalytic residue [active] 262316007264 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262316007265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316007266 metal binding site [ion binding]; metal-binding site 262316007267 active site 262316007268 I-site; other site 262316007269 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 262316007270 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 262316007271 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316007272 hypothetical protein; Validated; Region: PRK05868 262316007273 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316007274 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 262316007275 Fe-S cluster binding site [ion binding]; other site 262316007276 DNA binding site [nucleotide binding] 262316007277 active site 262316007278 H+ Antiporter protein; Region: 2A0121; TIGR00900 262316007279 FAD binding domain; Region: FAD_binding_4; pfam01565 262316007280 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 262316007281 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316007282 Cytochrome P450; Region: p450; cl12078 262316007283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007285 Acyltransferase family; Region: Acyl_transf_3; pfam01757 262316007286 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 262316007287 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 262316007288 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 262316007289 ATP binding site [chemical binding]; other site 262316007290 Mg++ binding site [ion binding]; other site 262316007291 motif III; other site 262316007292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316007293 nucleotide binding region [chemical binding]; other site 262316007294 ATP-binding site [chemical binding]; other site 262316007295 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 262316007296 putative RNA binding site [nucleotide binding]; other site 262316007297 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 262316007298 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316007299 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316007300 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316007301 Cytochrome P450; Region: p450; cl12078 262316007302 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316007303 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316007304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007305 NAD(P) binding site [chemical binding]; other site 262316007306 active site 262316007307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007309 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316007310 classical (c) SDRs; Region: SDR_c; cd05233 262316007311 NAD(P) binding site [chemical binding]; other site 262316007312 active site 262316007313 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316007314 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316007315 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316007316 classical (c) SDRs; Region: SDR_c; cd05233 262316007317 NAD(P) binding site [chemical binding]; other site 262316007318 active site 262316007319 SnoaL-like domain; Region: SnoaL_4; pfam13577 262316007320 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316007321 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 262316007322 RNase_H superfamily; Region: RNase_H_2; pfam13482 262316007323 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 262316007324 Part of AAA domain; Region: AAA_19; pfam13245 262316007325 AAA domain; Region: AAA_12; pfam13087 262316007326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316007327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316007328 putative substrate translocation pore; other site 262316007329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316007330 putative substrate translocation pore; other site 262316007331 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 262316007332 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262316007333 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 262316007334 TPP-binding site [chemical binding]; other site 262316007335 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 262316007336 dimer interface [polypeptide binding]; other site 262316007337 PYR/PP interface [polypeptide binding]; other site 262316007338 TPP binding site [chemical binding]; other site 262316007339 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 262316007340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007341 NAD(P) binding site [chemical binding]; other site 262316007342 active site 262316007343 short chain dehydrogenase; Provisional; Region: PRK07832 262316007344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007345 NAD(P) binding site [chemical binding]; other site 262316007346 active site 262316007347 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 262316007348 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 262316007349 Malic enzyme, N-terminal domain; Region: malic; pfam00390 262316007350 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 262316007351 putative NAD(P) binding site [chemical binding]; other site 262316007352 malate dehydrogenase; Provisional; Region: PRK05442 262316007353 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 262316007354 NAD(P) binding site [chemical binding]; other site 262316007355 dimer interface [polypeptide binding]; other site 262316007356 malate binding site [chemical binding]; other site 262316007357 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 262316007358 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 262316007359 oligomer interface [polypeptide binding]; other site 262316007360 metal binding site [ion binding]; metal-binding site 262316007361 metal binding site [ion binding]; metal-binding site 262316007362 putative Cl binding site [ion binding]; other site 262316007363 basic sphincter; other site 262316007364 hydrophobic gate; other site 262316007365 periplasmic entrance; other site 262316007366 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 262316007367 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 262316007368 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 262316007369 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 262316007370 Walker A/P-loop; other site 262316007371 ATP binding site [chemical binding]; other site 262316007372 Q-loop/lid; other site 262316007373 ABC transporter signature motif; other site 262316007374 Walker B; other site 262316007375 D-loop; other site 262316007376 H-loop/switch region; other site 262316007377 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262316007378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316007379 dimer interface [polypeptide binding]; other site 262316007380 conserved gate region; other site 262316007381 ABC-ATPase subunit interface; other site 262316007382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262316007383 dimer interface [polypeptide binding]; other site 262316007384 conserved gate region; other site 262316007385 putative PBP binding loops; other site 262316007386 ABC-ATPase subunit interface; other site 262316007387 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 262316007388 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 262316007389 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 262316007390 MgtE intracellular N domain; Region: MgtE_N; smart00924 262316007391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 262316007392 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 262316007393 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 262316007394 N-acetyl-D-glucosamine binding site [chemical binding]; other site 262316007395 catalytic residue [active] 262316007396 Domain of unknown function DUF59; Region: DUF59; cl00941 262316007397 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 262316007398 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 262316007399 sec-independent translocase; Provisional; Region: PRK03100 262316007400 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262316007401 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 262316007402 protein binding site [polypeptide binding]; other site 262316007403 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 262316007404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316007405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316007406 DNA binding residues [nucleotide binding] 262316007407 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316007408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316007409 S-adenosylmethionine binding site [chemical binding]; other site 262316007410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007411 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 262316007412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316007413 Q-loop/lid; other site 262316007414 ABC transporter signature motif; other site 262316007415 Walker B; other site 262316007416 D-loop; other site 262316007417 H-loop/switch region; other site 262316007418 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 262316007419 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 262316007420 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 262316007421 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 262316007422 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 262316007423 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 262316007424 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 262316007425 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 262316007426 ligand binding site; other site 262316007427 oligomer interface; other site 262316007428 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 262316007429 dimer interface [polypeptide binding]; other site 262316007430 N-terminal domain interface [polypeptide binding]; other site 262316007431 sulfate 1 binding site; other site 262316007432 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 262316007433 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316007434 Transposase domain (DUF772); Region: DUF772; pfam05598 262316007435 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 262316007436 DivIVA domain; Region: DivI1A_domain; TIGR03544 262316007437 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 262316007438 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 262316007439 active site 262316007440 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 262316007441 dihydropteroate synthase; Region: DHPS; TIGR01496 262316007442 substrate binding pocket [chemical binding]; other site 262316007443 dimer interface [polypeptide binding]; other site 262316007444 inhibitor binding site; inhibition site 262316007445 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 262316007446 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 262316007447 acyl-activating enzyme (AAE) consensus motif; other site 262316007448 putative AMP binding site [chemical binding]; other site 262316007449 putative active site [active] 262316007450 putative CoA binding site [chemical binding]; other site 262316007451 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 262316007452 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 262316007453 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 262316007454 metal binding site [ion binding]; metal-binding site 262316007455 putative dimer interface [polypeptide binding]; other site 262316007456 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316007457 PPE family; Region: PPE; pfam00823 262316007458 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316007459 PE family; Region: PE; pfam00934 262316007460 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316007461 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316007462 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316007463 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 262316007464 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 262316007465 putative trimer interface [polypeptide binding]; other site 262316007466 putative CoA binding site [chemical binding]; other site 262316007467 metabolite-proton symporter; Region: 2A0106; TIGR00883 262316007468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316007469 putative substrate translocation pore; other site 262316007470 acyl-CoA synthetase; Validated; Region: PRK07787 262316007471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316007472 acyl-activating enzyme (AAE) consensus motif; other site 262316007473 AMP binding site [chemical binding]; other site 262316007474 active site 262316007475 CoA binding site [chemical binding]; other site 262316007476 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316007477 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 262316007478 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316007479 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316007480 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316007481 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316007482 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316007483 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 262316007484 NAD binding site [chemical binding]; other site 262316007485 catalytic residues [active] 262316007486 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316007487 Cytochrome P450; Region: p450; cl12078 262316007488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316007489 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316007490 active site 262316007491 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316007492 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316007493 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316007494 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316007495 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316007496 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316007497 active site 262316007498 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 262316007499 putative active site [active] 262316007500 putative catalytic site [active] 262316007501 lipid-transfer protein; Provisional; Region: PRK07855 262316007502 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316007503 active site 262316007504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007506 Proline dehydrogenase; Region: Pro_dh; cl03282 262316007507 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316007508 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 262316007509 NAD(P) binding site [chemical binding]; other site 262316007510 catalytic residues [active] 262316007511 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 262316007512 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 262316007513 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316007514 PPE family; Region: PPE; pfam00823 262316007515 acyl-CoA synthetase; Validated; Region: PRK05850 262316007516 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316007517 acyl-activating enzyme (AAE) consensus motif; other site 262316007518 active site 262316007519 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262316007520 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 262316007521 ATP-sulfurylase; Region: ATPS; cd00517 262316007522 active site 262316007523 HXXH motif; other site 262316007524 flexible loop; other site 262316007525 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 262316007526 ligand-binding site [chemical binding]; other site 262316007527 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316007528 PPE family; Region: PPE; pfam00823 262316007529 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316007530 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316007531 PPE family; Region: PPE; pfam00823 262316007532 Acyl transferase domain; Region: Acyl_transf_1; cl08282 262316007533 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007535 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316007536 Enoylreductase; Region: PKS_ER; smart00829 262316007537 NAD(P) binding site [chemical binding]; other site 262316007538 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316007539 KR domain; Region: KR; pfam08659 262316007540 putative NADP binding site [chemical binding]; other site 262316007541 active site 262316007542 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316007543 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316007544 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 262316007545 active site 262316007546 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316007547 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 262316007548 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 262316007549 generic binding surface II; other site 262316007550 ssDNA binding site; other site 262316007551 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 262316007552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316007553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316007554 homodimer interface [polypeptide binding]; other site 262316007555 catalytic residue [active] 262316007556 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 262316007557 4Fe-4S binding domain; Region: Fer4; pfam00037 262316007558 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 262316007559 Winged helix-turn helix; Region: HTH_29; pfam13551 262316007560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316007561 Integrase core domain; Region: rve; pfam00665 262316007562 Integrase core domain; Region: rve_3; pfam13683 262316007563 FO synthase; Reviewed; Region: fbiC; PRK09234 262316007564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262316007565 FeS/SAM binding site; other site 262316007566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262316007567 FeS/SAM binding site; other site 262316007568 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 262316007569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007571 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 262316007572 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 262316007573 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262316007574 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 262316007575 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 262316007576 G1 box; other site 262316007577 putative GEF interaction site [polypeptide binding]; other site 262316007578 GTP/Mg2+ binding site [chemical binding]; other site 262316007579 Switch I region; other site 262316007580 G2 box; other site 262316007581 G3 box; other site 262316007582 Switch II region; other site 262316007583 G4 box; other site 262316007584 G5 box; other site 262316007585 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 262316007586 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 262316007587 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 262316007588 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 262316007589 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 262316007590 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 262316007591 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 262316007592 [4Fe-4S] binding site [ion binding]; other site 262316007593 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316007594 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316007595 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316007596 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 262316007597 molybdopterin cofactor binding site; other site 262316007598 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 262316007599 active site 262316007600 8-oxo-dGMP binding site [chemical binding]; other site 262316007601 nudix motif; other site 262316007602 metal binding site [ion binding]; metal-binding site 262316007603 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 262316007604 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 262316007605 aromatic arch; other site 262316007606 DCoH dimer interaction site [polypeptide binding]; other site 262316007607 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 262316007608 DCoH tetramer interaction site [polypeptide binding]; other site 262316007609 substrate binding site [chemical binding]; other site 262316007610 mannosyltransferase; Provisional; Region: pimE; PRK13375 262316007611 uncharacterized HhH-GPD family protein; Region: TIGR03252 262316007612 minor groove reading motif; other site 262316007613 helix-hairpin-helix signature motif; other site 262316007614 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 262316007615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 262316007616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316007617 DNA-binding site [nucleotide binding]; DNA binding site 262316007618 NAD-dependent deacetylase; Provisional; Region: PRK00481 262316007619 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 262316007620 NAD+ binding site [chemical binding]; other site 262316007621 substrate binding site [chemical binding]; other site 262316007622 Zn binding site [ion binding]; other site 262316007623 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262316007624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316007625 S-adenosylmethionine binding site [chemical binding]; other site 262316007626 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316007627 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 262316007628 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 262316007629 NAD binding site [chemical binding]; other site 262316007630 homodimer interface [polypeptide binding]; other site 262316007631 homotetramer interface [polypeptide binding]; other site 262316007632 active site 262316007633 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316007634 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316007635 enoyl-CoA hydratase; Provisional; Region: PRK06688 262316007636 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316007637 substrate binding site [chemical binding]; other site 262316007638 oxyanion hole (OAH) forming residues; other site 262316007639 trimer interface [polypeptide binding]; other site 262316007640 CAAX protease self-immunity; Region: Abi; pfam02517 262316007641 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 262316007642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007643 NAD(P) binding site [chemical binding]; other site 262316007644 active site 262316007645 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 262316007646 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 262316007647 malonyl-CoA binding site [chemical binding]; other site 262316007648 dimer interface [polypeptide binding]; other site 262316007649 active site 262316007650 product binding site; other site 262316007651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 262316007652 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 262316007653 enoyl-CoA hydratase; Provisional; Region: PRK08252 262316007654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316007655 substrate binding site [chemical binding]; other site 262316007656 oxyanion hole (OAH) forming residues; other site 262316007657 trimer interface [polypeptide binding]; other site 262316007658 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316007659 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316007660 dimer interface [polypeptide binding]; other site 262316007661 active site 262316007662 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316007663 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316007664 NAD(P) binding site [chemical binding]; other site 262316007665 catalytic residues [active] 262316007666 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316007667 Cytochrome P450; Region: p450; cl12078 262316007668 short chain dehydrogenase; Provisional; Region: PRK06179 262316007669 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 262316007670 NADP binding site [chemical binding]; other site 262316007671 active site 262316007672 steroid binding site; other site 262316007673 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 262316007674 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 262316007675 ligand binding site [chemical binding]; other site 262316007676 MoxR-like ATPases [General function prediction only]; Region: COG0714 262316007677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316007678 Walker A motif; other site 262316007679 ATP binding site [chemical binding]; other site 262316007680 Walker B motif; other site 262316007681 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 262316007682 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 262316007683 metal ion-dependent adhesion site (MIDAS); other site 262316007684 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 262316007685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316007686 active site 262316007687 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316007688 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316007689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316007690 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 262316007691 FMN binding site [chemical binding]; other site 262316007692 dimer interface [polypeptide binding]; other site 262316007693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007697 short chain dehydrogenase; Provisional; Region: PRK12829 262316007698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007699 NAD(P) binding site [chemical binding]; other site 262316007700 active site 262316007701 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 262316007702 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262316007703 NAD(P) binding site [chemical binding]; other site 262316007704 putative active site [active] 262316007705 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 262316007706 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 262316007707 THF binding site; other site 262316007708 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 262316007709 substrate binding site [chemical binding]; other site 262316007710 THF binding site; other site 262316007711 zinc-binding site [ion binding]; other site 262316007712 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 262316007713 Predicted membrane protein [Function unknown]; Region: COG2259 262316007714 pyruvate phosphate dikinase; Provisional; Region: PRK05878 262316007715 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 262316007716 FeoC like transcriptional regulator; Region: FeoC; cl17677 262316007717 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316007718 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 262316007719 dimer interface [polypeptide binding]; other site 262316007720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316007721 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316007722 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 262316007723 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262316007724 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 262316007725 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 262316007726 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 262316007727 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316007728 cyclase homology domain; Region: CHD; cd07302 262316007729 nucleotidyl binding site; other site 262316007730 metal binding site [ion binding]; metal-binding site 262316007731 dimer interface [polypeptide binding]; other site 262316007732 Uncharacterized conserved protein [Function unknown]; Region: COG1359 262316007733 NlpC/P60 family; Region: NLPC_P60; cl17555 262316007734 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316007735 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316007736 active site 262316007737 metal binding site [ion binding]; metal-binding site 262316007738 Domain of unknown function (DUF385); Region: DUF385; pfam04075 262316007739 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 262316007740 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316007741 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 262316007742 active site 262316007743 GTP-binding protein YchF; Reviewed; Region: PRK09601 262316007744 YchF GTPase; Region: YchF; cd01900 262316007745 G1 box; other site 262316007746 GTP/Mg2+ binding site [chemical binding]; other site 262316007747 Switch I region; other site 262316007748 G2 box; other site 262316007749 Switch II region; other site 262316007750 G3 box; other site 262316007751 G4 box; other site 262316007752 G5 box; other site 262316007753 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 262316007754 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 262316007755 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 262316007756 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 262316007757 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 262316007758 generic binding surface II; other site 262316007759 generic binding surface I; other site 262316007760 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 262316007761 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 262316007762 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 262316007763 putative NAD(P) binding site [chemical binding]; other site 262316007764 active site 262316007765 putative substrate binding site [chemical binding]; other site 262316007766 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 262316007767 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316007768 substrate binding pocket [chemical binding]; other site 262316007769 catalytic triad [active] 262316007770 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 262316007771 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 262316007772 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 262316007773 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 262316007774 putative active site [active] 262316007775 fumarate hydratase; Reviewed; Region: fumC; PRK00485 262316007776 Class II fumarases; Region: Fumarase_classII; cd01362 262316007777 active site 262316007778 tetramer interface [polypeptide binding]; other site 262316007779 HAMP domain; Region: HAMP; pfam00672 262316007780 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 262316007781 cyclase homology domain; Region: CHD; cd07302 262316007782 nucleotidyl binding site; other site 262316007783 metal binding site [ion binding]; metal-binding site 262316007784 dimer interface [polypeptide binding]; other site 262316007785 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 262316007786 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 262316007787 NodB motif; other site 262316007788 active site 262316007789 catalytic site [active] 262316007790 metal binding site [ion binding]; metal-binding site 262316007791 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 262316007792 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 262316007793 putative active site [active] 262316007794 PhoH-like protein; Region: PhoH; pfam02562 262316007795 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 262316007796 dinuclear metal binding motif [ion binding]; other site 262316007797 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 262316007798 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 262316007799 dimer interface [polypeptide binding]; other site 262316007800 active site 262316007801 glycine-pyridoxal phosphate binding site [chemical binding]; other site 262316007802 folate binding site [chemical binding]; other site 262316007803 pantothenate kinase; Provisional; Region: PRK05439 262316007804 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 262316007805 ATP-binding site [chemical binding]; other site 262316007806 CoA-binding site [chemical binding]; other site 262316007807 Mg2+-binding site [ion binding]; other site 262316007808 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 262316007809 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 262316007810 catalytic residue [active] 262316007811 putative FPP diphosphate binding site; other site 262316007812 putative FPP binding hydrophobic cleft; other site 262316007813 dimer interface [polypeptide binding]; other site 262316007814 putative IPP diphosphate binding site; other site 262316007815 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 262316007816 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 262316007817 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316007818 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 262316007819 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 262316007820 catalytic residues [active] 262316007821 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 262316007822 conserved cys residue [active] 262316007823 acyl-CoA thioesterase II; Region: tesB; TIGR00189 262316007824 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316007825 active site 262316007826 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316007827 catalytic triad [active] 262316007828 dimer interface [polypeptide binding]; other site 262316007829 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 262316007830 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 262316007831 active site 262316007832 multimer interface [polypeptide binding]; other site 262316007833 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 262316007834 nudix motif; other site 262316007835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316007836 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316007837 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 262316007838 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 262316007839 putative acyl-acceptor binding pocket; other site 262316007840 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 262316007841 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 262316007842 nucleotide binding site/active site [active] 262316007843 HIT family signature motif; other site 262316007844 catalytic residue [active] 262316007845 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 262316007846 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 262316007847 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 262316007848 active site 262316007849 dimer interface [polypeptide binding]; other site 262316007850 motif 1; other site 262316007851 motif 2; other site 262316007852 motif 3; other site 262316007853 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 262316007854 anticodon binding site; other site 262316007855 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 262316007856 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 262316007857 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 262316007858 metal binding site [ion binding]; metal-binding site 262316007859 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316007860 CoenzymeA binding site [chemical binding]; other site 262316007861 subunit interaction site [polypeptide binding]; other site 262316007862 PHB binding site; other site 262316007863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316007864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316007865 active site 262316007866 catalytic tetrad [active] 262316007867 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 262316007868 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262316007869 FMN binding site [chemical binding]; other site 262316007870 substrate binding site [chemical binding]; other site 262316007871 putative catalytic residue [active] 262316007872 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 262316007873 Helix-turn-helix domain; Region: HTH_20; pfam12840 262316007874 Predicted transcriptional regulator [Transcription]; Region: COG2345 262316007875 Ferredoxin [Energy production and conversion]; Region: COG1146 262316007876 4Fe-4S binding domain; Region: Fer4; pfam00037 262316007877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262316007878 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 262316007879 tetramer interface [polypeptide binding]; other site 262316007880 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 262316007881 heterodimer interface [polypeptide binding]; other site 262316007882 active site 262316007883 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 262316007884 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 262316007885 active site 262316007886 Hemerythrin-like domain; Region: Hr-like; cd12108 262316007887 Fe binding site [ion binding]; other site 262316007888 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 262316007889 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 262316007890 iron-sulfur cluster [ion binding]; other site 262316007891 [2Fe-2S] cluster binding site [ion binding]; other site 262316007892 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 262316007893 alpha subunit interaction site [polypeptide binding]; other site 262316007894 beta subunit interaction site [polypeptide binding]; other site 262316007895 iron-sulfur cluster [ion binding]; other site 262316007896 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 262316007897 beta subunit interface [polypeptide binding]; other site 262316007898 alpha subunit interface [polypeptide binding]; other site 262316007899 active site 262316007900 substrate binding site [chemical binding]; other site 262316007901 Fe binding site [ion binding]; other site 262316007902 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 262316007903 inter-subunit interface; other site 262316007904 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 262316007905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007906 NAD(P) binding site [chemical binding]; other site 262316007907 active site 262316007908 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 262316007909 intersubunit interface [polypeptide binding]; other site 262316007910 active site 262316007911 Zn2+ binding site [ion binding]; other site 262316007912 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 262316007913 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316007914 Bacterial transcriptional regulator; Region: IclR; pfam01614 262316007915 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 262316007916 active site 262316007917 catalytic triad [active] 262316007918 oxyanion hole [active] 262316007919 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262316007920 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262316007921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007923 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316007924 anti sigma factor interaction site; other site 262316007925 regulatory phosphorylation site [posttranslational modification]; other site 262316007926 Predicted permeases [General function prediction only]; Region: COG0730 262316007927 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 262316007928 putative heme binding pocket [chemical binding]; other site 262316007929 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316007930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316007931 NAD(P) binding site [chemical binding]; other site 262316007932 active site 262316007933 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 262316007934 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316007935 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 262316007936 acyl-activating enzyme (AAE) consensus motif; other site 262316007937 acyl-activating enzyme (AAE) consensus motif; other site 262316007938 putative AMP binding site [chemical binding]; other site 262316007939 putative active site [active] 262316007940 putative CoA binding site [chemical binding]; other site 262316007941 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316007942 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316007943 substrate binding site [chemical binding]; other site 262316007944 oxyanion hole (OAH) forming residues; other site 262316007945 trimer interface [polypeptide binding]; other site 262316007946 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316007947 hydrophobic ligand binding site; other site 262316007948 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 262316007949 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316007950 active site 262316007951 DNA binding site [nucleotide binding] 262316007952 Int/Topo IB signature motif; other site 262316007953 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 262316007954 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 262316007955 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 262316007956 Helix-turn-helix domain; Region: HTH_17; pfam12728 262316007957 AAA domain; Region: AAA_25; pfam13481 262316007958 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 262316007959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316007960 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316007961 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316007962 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 262316007963 hypothetical protein; Provisional; Region: PRK06194 262316007964 classical (c) SDRs; Region: SDR_c; cd05233 262316007965 NAD(P) binding site [chemical binding]; other site 262316007966 active site 262316007967 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316007968 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 262316007969 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316007970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316007971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316007972 short chain dehydrogenase; Provisional; Region: PRK12827 262316007973 classical (c) SDRs; Region: SDR_c; cd05233 262316007974 NAD(P) binding site [chemical binding]; other site 262316007975 active site 262316007976 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316007977 classical (c) SDRs; Region: SDR_c; cd05233 262316007978 NAD(P) binding site [chemical binding]; other site 262316007979 active site 262316007980 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316007981 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316007982 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316007983 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316007984 NAD(P) binding site [chemical binding]; other site 262316007985 catalytic residues [active] 262316007986 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 262316007987 Cation efflux family; Region: Cation_efflux; cl00316 262316007988 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316007989 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316007990 Clp protease ATP binding subunit; Region: clpC; CHL00095 262316007991 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 262316007992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316007993 Coenzyme A binding pocket [chemical binding]; other site 262316007994 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 262316007995 hypothetical protein; Provisional; Region: PRK14059 262316007996 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 262316007997 TAP-like protein; Region: Abhydrolase_4; pfam08386 262316007998 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 262316007999 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 262316008000 SelR domain; Region: SelR; pfam01641 262316008001 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262316008002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316008003 S-adenosylmethionine binding site [chemical binding]; other site 262316008004 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 262316008005 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 262316008006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316008007 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 262316008008 substrate binding site [chemical binding]; other site 262316008009 active site 262316008010 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316008011 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316008012 substrate binding site [chemical binding]; other site 262316008013 oxyanion hole (OAH) forming residues; other site 262316008014 trimer interface [polypeptide binding]; other site 262316008015 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 262316008016 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 262316008017 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 262316008018 catalytic site [active] 262316008019 putative active site [active] 262316008020 putative substrate binding site [chemical binding]; other site 262316008021 Helicase and RNase D C-terminal; Region: HRDC; smart00341 262316008022 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 262316008023 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 262316008024 TPP-binding site; other site 262316008025 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 262316008026 PYR/PP interface [polypeptide binding]; other site 262316008027 dimer interface [polypeptide binding]; other site 262316008028 TPP binding site [chemical binding]; other site 262316008029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262316008030 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 262316008031 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 262316008032 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 262316008033 transmembrane helices; other site 262316008034 TRAM domain; Region: TRAM; pfam01938 262316008035 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 262316008036 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 262316008037 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 262316008038 TrkA-N domain; Region: TrkA_N; pfam02254 262316008039 TrkA-C domain; Region: TrkA_C; pfam02080 262316008040 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 262316008041 TrkA-N domain; Region: TrkA_N; pfam02254 262316008042 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 262316008043 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 262316008044 generic binding surface II; other site 262316008045 ssDNA binding site; other site 262316008046 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 262316008047 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 262316008048 trimer interface [polypeptide binding]; other site 262316008049 active site 262316008050 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 262316008051 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 262316008052 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 262316008053 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 262316008054 active site 262316008055 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262316008056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316008057 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 262316008058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316008059 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316008060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316008061 DNA binding residues [nucleotide binding] 262316008062 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 262316008063 homotrimer interaction site [polypeptide binding]; other site 262316008064 putative active site [active] 262316008065 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 262316008066 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 262316008067 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 262316008068 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 262316008069 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 262316008070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316008071 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316008072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316008073 DNA binding residues [nucleotide binding] 262316008074 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 262316008075 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 262316008076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316008077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316008078 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316008079 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 262316008080 PAC2 family; Region: PAC2; pfam09754 262316008081 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316008082 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 262316008083 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 262316008084 heme-binding site [chemical binding]; other site 262316008085 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 262316008086 ATP cone domain; Region: ATP-cone; pfam03477 262316008087 LysM domain; Region: LysM; pfam01476 262316008088 LexA repressor; Validated; Region: PRK00215 262316008089 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 262316008090 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 262316008091 Catalytic site [active] 262316008092 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 262316008093 LGFP repeat; Region: LGFP; pfam08310 262316008094 LGFP repeat; Region: LGFP; pfam08310 262316008095 LGFP repeat; Region: LGFP; pfam08310 262316008096 LGFP repeat; Region: LGFP; pfam08310 262316008097 LGFP repeat; Region: LGFP; pfam08310 262316008098 LGFP repeat; Region: LGFP; pfam08310 262316008099 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008101 active site 262316008102 GTPases [General function prediction only]; Region: HflX; COG2262 262316008103 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 262316008104 HflX GTPase family; Region: HflX; cd01878 262316008105 G1 box; other site 262316008106 GTP/Mg2+ binding site [chemical binding]; other site 262316008107 Switch I region; other site 262316008108 G2 box; other site 262316008109 G3 box; other site 262316008110 Switch II region; other site 262316008111 G4 box; other site 262316008112 G5 box; other site 262316008113 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 262316008114 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 262316008115 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 262316008116 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 262316008117 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 262316008118 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 262316008119 active site 262316008120 metal binding site [ion binding]; metal-binding site 262316008121 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 262316008122 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 262316008123 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 262316008124 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 262316008125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262316008126 FeS/SAM binding site; other site 262316008127 recombination regulator RecX; Reviewed; Region: recX; PRK00117 262316008128 recombinase A; Provisional; Region: recA; PRK09354 262316008129 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 262316008130 hexamer interface [polypeptide binding]; other site 262316008131 Walker A motif; other site 262316008132 ATP binding site [chemical binding]; other site 262316008133 Walker B motif; other site 262316008134 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 262316008135 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 262316008136 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 262316008137 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316008138 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262316008139 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 262316008140 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 262316008141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316008142 non-specific DNA binding site [nucleotide binding]; other site 262316008143 salt bridge; other site 262316008144 sequence-specific DNA binding site [nucleotide binding]; other site 262316008145 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 262316008146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316008147 Coenzyme A binding pocket [chemical binding]; other site 262316008148 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 262316008149 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316008150 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 262316008151 Uncharacterized conserved protein [Function unknown]; Region: COG1359 262316008152 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 262316008153 classical (c) SDRs; Region: SDR_c; cd05233 262316008154 NAD(P) binding site [chemical binding]; other site 262316008155 active site 262316008156 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316008157 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316008158 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 262316008159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316008160 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 262316008161 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 262316008162 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 262316008163 dimer interface [polypeptide binding]; other site 262316008164 active site 262316008165 catalytic residue [active] 262316008166 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 262316008167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 262316008168 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 262316008169 DivIVA protein; Region: DivIVA; pfam05103 262316008170 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 262316008171 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 262316008172 folate binding site [chemical binding]; other site 262316008173 NADP+ binding site [chemical binding]; other site 262316008174 thymidylate synthase; Reviewed; Region: thyA; PRK01827 262316008175 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 262316008176 dimerization interface [polypeptide binding]; other site 262316008177 active site 262316008178 Dienelactone hydrolase family; Region: DLH; pfam01738 262316008179 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 262316008180 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316008181 homodimer interface [polypeptide binding]; other site 262316008182 active site 262316008183 TDP-binding site; other site 262316008184 acceptor substrate-binding pocket; other site 262316008185 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 262316008186 classical (c) SDRs; Region: SDR_c; cd05233 262316008187 NAD(P) binding site [chemical binding]; other site 262316008188 active site 262316008189 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 262316008190 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316008191 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316008192 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 262316008193 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 262316008194 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262316008195 carboxyltransferase (CT) interaction site; other site 262316008196 biotinylation site [posttranslational modification]; other site 262316008197 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316008198 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262316008199 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316008200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316008201 acyl-activating enzyme (AAE) consensus motif; other site 262316008202 AMP binding site [chemical binding]; other site 262316008203 active site 262316008204 CoA binding site [chemical binding]; other site 262316008205 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 262316008206 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316008207 active site 2 [active] 262316008208 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 262316008209 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262316008210 dihydrodipicolinate reductase; Provisional; Region: PRK00048 262316008211 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 262316008212 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 262316008213 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316008214 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316008215 active site 262316008216 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316008217 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 262316008218 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316008219 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316008220 [2Fe-2S] cluster binding site [ion binding]; other site 262316008221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008222 Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane...; Region: Bcl-2_like; cl02575 262316008223 BH3; other site 262316008224 BH3-homology region binding site; other site 262316008225 BH1; other site 262316008226 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316008227 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 262316008228 FMN-binding pocket [chemical binding]; other site 262316008229 flavin binding motif; other site 262316008230 phosphate binding motif [ion binding]; other site 262316008231 beta-alpha-beta structure motif; other site 262316008232 NAD binding pocket [chemical binding]; other site 262316008233 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316008234 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 262316008235 catalytic loop [active] 262316008236 iron binding site [ion binding]; other site 262316008237 short chain dehydrogenase; Validated; Region: PRK05855 262316008238 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316008239 classical (c) SDRs; Region: SDR_c; cd05233 262316008240 NAD(P) binding site [chemical binding]; other site 262316008241 active site 262316008242 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 262316008243 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 262316008244 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316008245 hydrophobic ligand binding site; other site 262316008246 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 262316008247 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 262316008248 hexamer interface [polypeptide binding]; other site 262316008249 ligand binding site [chemical binding]; other site 262316008250 putative active site [active] 262316008251 NAD(P) binding site [chemical binding]; other site 262316008252 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 262316008253 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262316008254 FMN binding site [chemical binding]; other site 262316008255 substrate binding site [chemical binding]; other site 262316008256 putative catalytic residue [active] 262316008257 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 262316008258 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 262316008259 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 262316008260 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 262316008261 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 262316008262 oligomer interface [polypeptide binding]; other site 262316008263 RNA binding site [nucleotide binding]; other site 262316008264 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 262316008265 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 262316008266 RNase E interface [polypeptide binding]; other site 262316008267 trimer interface [polypeptide binding]; other site 262316008268 active site 262316008269 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 262316008270 putative nucleic acid binding region [nucleotide binding]; other site 262316008271 G-X-X-G motif; other site 262316008272 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 262316008273 RNA binding site [nucleotide binding]; other site 262316008274 domain interface; other site 262316008275 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 262316008276 16S/18S rRNA binding site [nucleotide binding]; other site 262316008277 S13e-L30e interaction site [polypeptide binding]; other site 262316008278 25S rRNA binding site [nucleotide binding]; other site 262316008279 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 262316008280 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 262316008281 active site 262316008282 Riboflavin kinase; Region: Flavokinase; smart00904 262316008283 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 262316008284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 262316008285 putative DNA binding site [nucleotide binding]; other site 262316008286 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 262316008287 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 262316008288 FeoA domain; Region: FeoA; pfam04023 262316008289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008290 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008291 active site 262316008292 lipid-transfer protein; Provisional; Region: PRK08256 262316008293 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316008294 active site 262316008295 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 262316008296 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 262316008297 RNA binding site [nucleotide binding]; other site 262316008298 active site 262316008299 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 262316008300 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 262316008301 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 262316008302 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 262316008303 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262316008304 active site 262316008305 metal binding site [ion binding]; metal-binding site 262316008306 Predicted acyl esterases [General function prediction only]; Region: COG2936 262316008307 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 262316008308 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 262316008309 enoyl-CoA hydratase; Provisional; Region: PRK06190 262316008310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316008311 substrate binding site [chemical binding]; other site 262316008312 oxyanion hole (OAH) forming residues; other site 262316008313 trimer interface [polypeptide binding]; other site 262316008314 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 262316008315 DHH family; Region: DHH; pfam01368 262316008316 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 262316008317 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262316008318 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262316008319 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 262316008320 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 262316008321 G1 box; other site 262316008322 putative GEF interaction site [polypeptide binding]; other site 262316008323 GTP/Mg2+ binding site [chemical binding]; other site 262316008324 Switch I region; other site 262316008325 G2 box; other site 262316008326 G3 box; other site 262316008327 Switch II region; other site 262316008328 G4 box; other site 262316008329 G5 box; other site 262316008330 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 262316008331 Translation-initiation factor 2; Region: IF-2; pfam11987 262316008332 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 262316008333 Protein of unknown function (DUF448); Region: DUF448; pfam04296 262316008334 putative RNA binding cleft [nucleotide binding]; other site 262316008335 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 262316008336 NusA N-terminal domain; Region: NusA_N; pfam08529 262316008337 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 262316008338 RNA binding site [nucleotide binding]; other site 262316008339 homodimer interface [polypeptide binding]; other site 262316008340 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 262316008341 G-X-X-G motif; other site 262316008342 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 262316008343 G-X-X-G motif; other site 262316008344 ribosome maturation protein RimP; Reviewed; Region: PRK00092 262316008345 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 262316008346 putative oligomer interface [polypeptide binding]; other site 262316008347 putative RNA binding site [nucleotide binding]; other site 262316008348 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 262316008349 dinuclear metal binding motif [ion binding]; other site 262316008350 prolyl-tRNA synthetase; Provisional; Region: PRK09194 262316008351 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 262316008352 dimer interface [polypeptide binding]; other site 262316008353 motif 1; other site 262316008354 active site 262316008355 motif 2; other site 262316008356 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 262316008357 putative deacylase active site [active] 262316008358 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262316008359 active site 262316008360 motif 3; other site 262316008361 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 262316008362 anticodon binding site; other site 262316008363 hypothetical protein; Provisional; Region: PRK01346 262316008364 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 262316008365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316008366 putative substrate translocation pore; other site 262316008367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316008368 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 262316008369 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 262316008370 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 262316008371 active site 262316008372 SAM binding site [chemical binding]; other site 262316008373 homodimer interface [polypeptide binding]; other site 262316008374 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 262316008375 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 262316008376 catalytic triad [active] 262316008377 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 262316008378 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 262316008379 Walker A motif; other site 262316008380 homodimer interface [polypeptide binding]; other site 262316008381 ATP binding site [chemical binding]; other site 262316008382 hydroxycobalamin binding site [chemical binding]; other site 262316008383 Walker B motif; other site 262316008384 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 262316008385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 262316008386 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 262316008387 metal ion-dependent adhesion site (MIDAS); other site 262316008388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316008389 Coenzyme A binding pocket [chemical binding]; other site 262316008390 malate:quinone oxidoreductase; Validated; Region: PRK05257 262316008391 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 262316008392 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 262316008393 mycothione reductase; Reviewed; Region: PRK07846 262316008394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316008395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316008396 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316008397 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 262316008398 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 262316008399 Uncharacterized conserved protein [Function unknown]; Region: COG3379 262316008400 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316008401 PPE family; Region: PPE; pfam00823 262316008402 short chain dehydrogenase; Provisional; Region: PRK06057 262316008403 classical (c) SDRs; Region: SDR_c; cd05233 262316008404 NAD(P) binding site [chemical binding]; other site 262316008405 active site 262316008406 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 262316008407 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 262316008408 NAD(P) binding site [chemical binding]; other site 262316008409 catalytic residues [active] 262316008410 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 262316008411 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 262316008412 catalytic triad [active] 262316008413 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 262316008414 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 262316008415 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 262316008416 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316008417 cobyric acid synthase; Provisional; Region: PRK00784 262316008418 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262316008419 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262316008420 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 262316008421 catalytic triad [active] 262316008422 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 262316008423 active site 262316008424 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 262316008425 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 262316008426 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 262316008427 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 262316008428 Predicted acetyltransferase [General function prediction only]; Region: COG3393 262316008429 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 262316008430 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 262316008431 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 262316008432 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 262316008433 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 262316008434 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 262316008435 active site 262316008436 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 262316008437 protein binding site [polypeptide binding]; other site 262316008438 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 262316008439 putative substrate binding region [chemical binding]; other site 262316008440 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 262316008441 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 262316008442 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 262316008443 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 262316008444 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 262316008445 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 262316008446 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262316008447 catalytic residues [active] 262316008448 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 262316008449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262316008450 FeS/SAM binding site; other site 262316008451 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 262316008452 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 262316008453 ribosome recycling factor; Reviewed; Region: frr; PRK00083 262316008454 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 262316008455 hinge region; other site 262316008456 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 262316008457 putative nucleotide binding site [chemical binding]; other site 262316008458 uridine monophosphate binding site [chemical binding]; other site 262316008459 homohexameric interface [polypeptide binding]; other site 262316008460 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316008461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316008462 DNA binding site [nucleotide binding] 262316008463 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316008464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316008465 putative acyl-acceptor binding pocket; other site 262316008466 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 262316008467 short chain dehydrogenase; Provisional; Region: PRK06701 262316008468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008469 NAD(P) binding site [chemical binding]; other site 262316008470 active site 262316008471 ChaB; Region: ChaB; pfam06150 262316008472 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 262316008473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316008474 MarR family; Region: MarR; pfam01047 262316008475 amidase; Provisional; Region: PRK07869 262316008476 Amidase; Region: Amidase; pfam01425 262316008477 elongation factor Ts; Provisional; Region: tsf; PRK09377 262316008478 UBA/TS-N domain; Region: UBA; pfam00627 262316008479 Elongation factor TS; Region: EF_TS; pfam00889 262316008480 Elongation factor TS; Region: EF_TS; pfam00889 262316008481 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 262316008482 rRNA interaction site [nucleotide binding]; other site 262316008483 S8 interaction site; other site 262316008484 putative laminin-1 binding site; other site 262316008485 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 262316008486 Peptidase family M23; Region: Peptidase_M23; pfam01551 262316008487 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 262316008488 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316008489 active site 262316008490 DNA binding site [nucleotide binding] 262316008491 Int/Topo IB signature motif; other site 262316008492 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 262316008493 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 262316008494 putative active site [active] 262316008495 putative substrate binding site [chemical binding]; other site 262316008496 putative FMN binding site [chemical binding]; other site 262316008497 putative catalytic residues [active] 262316008498 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 262316008499 FAD binding pocket [chemical binding]; other site 262316008500 FAD binding motif [chemical binding]; other site 262316008501 phosphate binding motif [ion binding]; other site 262316008502 NAD binding pocket [chemical binding]; other site 262316008503 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 262316008504 DNA protecting protein DprA; Region: dprA; TIGR00732 262316008505 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 262316008506 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 262316008507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316008508 Walker A motif; other site 262316008509 ATP binding site [chemical binding]; other site 262316008510 Walker B motif; other site 262316008511 arginine finger; other site 262316008512 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 262316008513 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 262316008514 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 262316008515 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316008516 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 262316008517 active site 262316008518 DNA binding site [nucleotide binding] 262316008519 Int/Topo IB signature motif; other site 262316008520 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 262316008521 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 262316008522 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 262316008523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316008524 putative NAD(P) binding site [chemical binding]; other site 262316008525 active site 262316008526 putative substrate binding site [chemical binding]; other site 262316008527 ANTAR domain; Region: ANTAR; pfam03861 262316008528 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 262316008529 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 262316008530 RNA/DNA hybrid binding site [nucleotide binding]; other site 262316008531 active site 262316008532 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 262316008533 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 262316008534 Catalytic site [active] 262316008535 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 262316008536 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 262316008537 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 262316008538 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 262316008539 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 262316008540 RimM N-terminal domain; Region: RimM; pfam01782 262316008541 PRC-barrel domain; Region: PRC; pfam05239 262316008542 hypothetical protein; Provisional; Region: PRK02821 262316008543 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 262316008544 G-X-X-G motif; other site 262316008545 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 262316008546 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 262316008547 SnoaL-like domain; Region: SnoaL_3; pfam13474 262316008548 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 262316008549 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 262316008550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008552 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316008553 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316008554 active site 262316008555 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316008556 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 262316008557 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316008558 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316008559 active site 262316008560 signal recognition particle protein; Provisional; Region: PRK10867 262316008561 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 262316008562 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 262316008563 P loop; other site 262316008564 GTP binding site [chemical binding]; other site 262316008565 Signal peptide binding domain; Region: SRP_SPB; pfam02978 262316008566 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316008567 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 262316008568 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 262316008569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316008570 ATP binding site [chemical binding]; other site 262316008571 putative Mg++ binding site [ion binding]; other site 262316008572 PII uridylyl-transferase; Provisional; Region: PRK03381 262316008573 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 262316008574 metal binding triad; other site 262316008575 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 262316008576 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262316008577 Zn2+ binding site [ion binding]; other site 262316008578 Mg2+ binding site [ion binding]; other site 262316008579 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 262316008580 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 262316008581 Nitrogen regulatory protein P-II; Region: P-II; smart00938 262316008582 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 262316008583 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 262316008584 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 262316008585 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262316008586 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 262316008587 AAA domain; Region: AAA_23; pfam13476 262316008588 Walker A/P-loop; other site 262316008589 ATP binding site [chemical binding]; other site 262316008590 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 262316008591 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 262316008592 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 262316008593 ABC transporter signature motif; other site 262316008594 Walker B; other site 262316008595 D-loop; other site 262316008596 H-loop/switch region; other site 262316008597 acylphosphatase; Provisional; Region: PRK14422 262316008598 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 262316008599 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 262316008600 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 262316008601 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 262316008602 DNA binding site [nucleotide binding] 262316008603 catalytic residue [active] 262316008604 H2TH interface [polypeptide binding]; other site 262316008605 putative catalytic residues [active] 262316008606 turnover-facilitating residue; other site 262316008607 intercalation triad [nucleotide binding]; other site 262316008608 8OG recognition residue [nucleotide binding]; other site 262316008609 putative reading head residues; other site 262316008610 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316008611 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316008612 ribonuclease III; Reviewed; Region: rnc; PRK00102 262316008613 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 262316008614 dimerization interface [polypeptide binding]; other site 262316008615 active site 262316008616 metal binding site [ion binding]; metal-binding site 262316008617 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 262316008618 dsRNA binding site [nucleotide binding]; other site 262316008619 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 262316008620 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 262316008621 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 262316008622 Predicted permease; Region: DUF318; cl17795 262316008623 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 262316008624 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316008625 PYR/PP interface [polypeptide binding]; other site 262316008626 dimer interface [polypeptide binding]; other site 262316008627 TPP binding site [chemical binding]; other site 262316008628 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316008629 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 262316008630 TPP-binding site [chemical binding]; other site 262316008631 dimer interface [polypeptide binding]; other site 262316008632 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316008633 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316008634 active site 262316008635 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 262316008636 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 262316008637 active site 262316008638 (T/H)XGH motif; other site 262316008639 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 262316008640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262316008641 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 262316008642 putative active site [active] 262316008643 redox center [active] 262316008644 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 262316008645 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 262316008646 catalytic residues [active] 262316008647 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316008648 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316008649 substrate binding pocket [chemical binding]; other site 262316008650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316008651 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316008652 active site 262316008653 catalytic tetrad [active] 262316008654 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 262316008655 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 262316008656 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 262316008657 ssDNA binding site; other site 262316008658 generic binding surface II; other site 262316008659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316008660 ATP binding site [chemical binding]; other site 262316008661 putative Mg++ binding site [ion binding]; other site 262316008662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316008663 nucleotide binding region [chemical binding]; other site 262316008664 ATP-binding site [chemical binding]; other site 262316008665 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 262316008666 DAK2 domain; Region: Dak2; pfam02734 262316008667 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 262316008668 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316008669 classical (c) SDRs; Region: SDR_c; cd05233 262316008670 NAD(P) binding site [chemical binding]; other site 262316008671 active site 262316008672 short chain dehydrogenase; Provisional; Region: PRK06197 262316008673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008674 NAD(P) binding site [chemical binding]; other site 262316008675 active site 262316008676 short chain dehydrogenase; Provisional; Region: PRK06180 262316008677 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 262316008678 NADP binding site [chemical binding]; other site 262316008679 active site 262316008680 steroid binding site; other site 262316008681 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 262316008682 ligand binding site [chemical binding]; other site 262316008683 active site 262316008684 UGI interface [polypeptide binding]; other site 262316008685 catalytic site [active] 262316008686 thiamine monophosphate kinase; Provisional; Region: PRK05731 262316008687 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 262316008688 ATP binding site [chemical binding]; other site 262316008689 dimerization interface [polypeptide binding]; other site 262316008690 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 262316008691 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 262316008692 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 262316008693 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 262316008694 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 262316008695 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 262316008696 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 262316008697 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 262316008698 polyphosphate kinase; Provisional; Region: PRK05443 262316008699 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 262316008700 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 262316008701 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 262316008702 putative domain interface [polypeptide binding]; other site 262316008703 putative active site [active] 262316008704 catalytic site [active] 262316008705 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 262316008706 putative domain interface [polypeptide binding]; other site 262316008707 putative active site [active] 262316008708 catalytic site [active] 262316008709 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 262316008710 active site 262316008711 Ap6A binding site [chemical binding]; other site 262316008712 nudix motif; other site 262316008713 metal binding site [ion binding]; metal-binding site 262316008714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316008715 catalytic core [active] 262316008716 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 262316008717 IHF - DNA interface [nucleotide binding]; other site 262316008718 IHF dimer interface [polypeptide binding]; other site 262316008719 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 262316008720 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 262316008721 substrate binding site [chemical binding]; other site 262316008722 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 262316008723 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 262316008724 substrate binding site [chemical binding]; other site 262316008725 ligand binding site [chemical binding]; other site 262316008726 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 262316008727 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316008728 Bacterial transcriptional regulator; Region: IclR; pfam01614 262316008729 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 262316008730 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 262316008731 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316008732 active site 262316008733 HIGH motif; other site 262316008734 nucleotide binding site [chemical binding]; other site 262316008735 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 262316008736 active site 262316008737 KMSKS motif; other site 262316008738 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 262316008739 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 262316008740 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 262316008741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316008742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316008743 putative substrate translocation pore; other site 262316008744 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 262316008745 tartrate dehydrogenase; Region: TTC; TIGR02089 262316008746 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 262316008747 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 262316008748 ligand binding site [chemical binding]; other site 262316008749 NAD binding site [chemical binding]; other site 262316008750 dimerization interface [polypeptide binding]; other site 262316008751 catalytic site [active] 262316008752 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 262316008753 putative L-serine binding site [chemical binding]; other site 262316008754 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 262316008755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316008756 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262316008757 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262316008758 ketol-acid reductoisomerase; Provisional; Region: PRK05479 262316008759 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 262316008760 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 262316008761 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 262316008762 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 262316008763 putative valine binding site [chemical binding]; other site 262316008764 dimer interface [polypeptide binding]; other site 262316008765 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 262316008766 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 262316008767 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316008768 PYR/PP interface [polypeptide binding]; other site 262316008769 dimer interface [polypeptide binding]; other site 262316008770 TPP binding site [chemical binding]; other site 262316008771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316008772 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 262316008773 TPP-binding site [chemical binding]; other site 262316008774 dimer interface [polypeptide binding]; other site 262316008775 Predicted membrane protein [Function unknown]; Region: COG2259 262316008776 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 262316008777 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 262316008778 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 262316008779 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 262316008780 GatB domain; Region: GatB_Yqey; smart00845 262316008781 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316008782 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 262316008783 P-loop; other site 262316008784 Magnesium ion binding site [ion binding]; other site 262316008785 6-phosphofructokinase; Provisional; Region: PRK03202 262316008786 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 262316008787 active site 262316008788 ADP/pyrophosphate binding site [chemical binding]; other site 262316008789 dimerization interface [polypeptide binding]; other site 262316008790 allosteric effector site; other site 262316008791 fructose-1,6-bisphosphate binding site; other site 262316008792 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 262316008793 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 262316008794 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 262316008795 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 262316008796 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316008797 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316008798 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 262316008799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008801 cystathionine gamma-lyase; Validated; Region: PRK07582 262316008802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 262316008803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316008804 catalytic residue [active] 262316008805 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 262316008806 PknH-like extracellular domain; Region: PknH_C; pfam14032 262316008807 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 262316008808 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 262316008809 Ligand Binding Site [chemical binding]; other site 262316008810 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 262316008811 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 262316008812 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262316008813 catalytic residue [active] 262316008814 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 262316008815 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 262316008816 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 262316008817 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 262316008818 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 262316008819 Ligand binding site [chemical binding]; other site 262316008820 Electron transfer flavoprotein domain; Region: ETF; pfam01012 262316008821 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262316008822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316008823 S-adenosylmethionine binding site [chemical binding]; other site 262316008824 Uncharacterized conserved protein [Function unknown]; Region: COG1543 262316008825 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 262316008826 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 262316008827 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316008828 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316008829 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316008830 hydrophobic ligand binding site; other site 262316008831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008832 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 262316008833 NAD(P) binding site [chemical binding]; other site 262316008834 active site 262316008835 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316008836 anti sigma factor interaction site; other site 262316008837 regulatory phosphorylation site [posttranslational modification]; other site 262316008838 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316008839 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 262316008840 substrate binding pocket [chemical binding]; other site 262316008841 chain length determination region; other site 262316008842 substrate-Mg2+ binding site; other site 262316008843 catalytic residues [active] 262316008844 aspartate-rich region 1; other site 262316008845 active site lid residues [active] 262316008846 aspartate-rich region 2; other site 262316008847 phytoene desaturase; Region: crtI_fam; TIGR02734 262316008848 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 262316008849 catalytic residues [active] 262316008850 substrate binding pocket [chemical binding]; other site 262316008851 aspartate-rich region 2; other site 262316008852 substrate-Mg2+ binding site; other site 262316008853 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 262316008854 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 262316008855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262316008856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316008857 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 262316008858 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 262316008859 [2Fe-2S] cluster binding site [ion binding]; other site 262316008860 iron-sulfur cluster [ion binding]; other site 262316008861 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316008862 MarR family; Region: MarR_2; pfam12802 262316008863 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 262316008864 Winged helix-turn helix; Region: HTH_29; pfam13551 262316008865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316008866 Integrase core domain; Region: rve; pfam00665 262316008867 Integrase core domain; Region: rve_3; pfam13683 262316008868 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 262316008869 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 262316008870 homotetramer interface [polypeptide binding]; other site 262316008871 FMN binding site [chemical binding]; other site 262316008872 homodimer contacts [polypeptide binding]; other site 262316008873 putative active site [active] 262316008874 putative substrate binding site [chemical binding]; other site 262316008875 MMPL family; Region: MMPL; pfam03176 262316008876 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 262316008877 DNA photolyase; Region: DNA_photolyase; pfam00875 262316008878 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 262316008879 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 262316008880 trimer interface [polypeptide binding]; other site 262316008881 active site 262316008882 substrate binding site [chemical binding]; other site 262316008883 CoA binding site [chemical binding]; other site 262316008884 FOG: WD40-like repeat [Function unknown]; Region: COG1520 262316008885 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 262316008886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316008887 S-adenosylmethionine binding site [chemical binding]; other site 262316008888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316008889 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 262316008890 substrate binding site [chemical binding]; other site 262316008891 oxyanion hole (OAH) forming residues; other site 262316008892 trimer interface [polypeptide binding]; other site 262316008893 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 262316008894 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 262316008895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316008896 Walker A/P-loop; other site 262316008897 ATP binding site [chemical binding]; other site 262316008898 ABC transporter signature motif; other site 262316008899 Walker B; other site 262316008900 D-loop; other site 262316008901 H-loop/switch region; other site 262316008902 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 262316008903 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 262316008904 phosphoserine phosphatase SerB; Region: serB; TIGR00338 262316008905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316008906 motif II; other site 262316008907 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 262316008908 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 262316008909 D-pathway; other site 262316008910 Putative ubiquinol binding site [chemical binding]; other site 262316008911 Low-spin heme (heme b) binding site [chemical binding]; other site 262316008912 Putative water exit pathway; other site 262316008913 Binuclear center (heme o3/CuB) [ion binding]; other site 262316008914 K-pathway; other site 262316008915 Putative proton exit pathway; other site 262316008916 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 262316008917 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 262316008918 siderophore binding site; other site 262316008919 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 262316008920 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 262316008921 putative NAD(P) binding site [chemical binding]; other site 262316008922 putative substrate binding site [chemical binding]; other site 262316008923 catalytic Zn binding site [ion binding]; other site 262316008924 structural Zn binding site [ion binding]; other site 262316008925 dimer interface [polypeptide binding]; other site 262316008926 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 262316008927 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 262316008928 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 262316008929 dimer interface [polypeptide binding]; other site 262316008930 putative radical transfer pathway; other site 262316008931 diiron center [ion binding]; other site 262316008932 tyrosyl radical; other site 262316008933 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 262316008934 putative hydrophobic ligand binding site [chemical binding]; other site 262316008935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008937 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316008938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316008939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008941 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 262316008942 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 262316008943 Class I ribonucleotide reductase; Region: RNR_I; cd01679 262316008944 active site 262316008945 dimer interface [polypeptide binding]; other site 262316008946 catalytic residues [active] 262316008947 effector binding site; other site 262316008948 R2 peptide binding site; other site 262316008949 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 262316008950 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 262316008951 catalytic residues [active] 262316008952 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262316008953 Predicted flavoprotein [General function prediction only]; Region: COG0431 262316008954 DNA polymerase IV; Validated; Region: PRK03352 262316008955 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262316008956 active site 262316008957 DNA binding site [nucleotide binding] 262316008958 short chain dehydrogenase; Provisional; Region: PRK07832 262316008959 classical (c) SDRs; Region: SDR_c; cd05233 262316008960 NAD(P) binding site [chemical binding]; other site 262316008961 active site 262316008962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316008963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316008964 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316008965 Cytochrome P450; Region: p450; cl12078 262316008966 2-isopropylmalate synthase; Validated; Region: PRK03739 262316008967 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 262316008968 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 262316008969 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 262316008970 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316008971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316008972 DNA-binding site [nucleotide binding]; DNA binding site 262316008973 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 262316008974 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316008975 FCD domain; Region: FCD; pfam07729 262316008976 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316008977 active site 262316008978 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316008979 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316008980 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316008981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008982 active site 262316008983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316008984 active site 262316008985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316008986 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 262316008987 NAD(P) binding site [chemical binding]; other site 262316008988 active site 262316008989 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 262316008990 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 262316008991 active site 262316008992 DNA binding site [nucleotide binding] 262316008993 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 262316008994 DNA binding site [nucleotide binding] 262316008995 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 262316008996 Carbon starvation protein CstA; Region: CstA; pfam02554 262316008997 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 262316008998 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 262316008999 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 262316009000 nucleotide binding site [chemical binding]; other site 262316009001 putative NEF/HSP70 interaction site [polypeptide binding]; other site 262316009002 SBD interface [polypeptide binding]; other site 262316009003 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316009004 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 262316009005 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316009006 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316009007 substrate binding site [chemical binding]; other site 262316009008 oxyanion hole (OAH) forming residues; other site 262316009009 trimer interface [polypeptide binding]; other site 262316009010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009012 active site 262316009013 MspA; Region: MspA; pfam09203 262316009014 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 262316009015 Phosphotransferase enzyme family; Region: APH; pfam01636 262316009016 putative active site [active] 262316009017 ATP binding site [chemical binding]; other site 262316009018 putative substrate binding site [chemical binding]; other site 262316009019 short chain dehydrogenase; Provisional; Region: PRK07326 262316009020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009021 NAD(P) binding site [chemical binding]; other site 262316009022 active site 262316009023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316009024 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 262316009025 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316009026 Transport protein; Region: actII; TIGR00833 262316009027 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262316009028 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 262316009029 Walker A/P-loop; other site 262316009030 ATP binding site [chemical binding]; other site 262316009031 Q-loop/lid; other site 262316009032 ABC transporter signature motif; other site 262316009033 Walker B; other site 262316009034 D-loop; other site 262316009035 H-loop/switch region; other site 262316009036 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316009037 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262316009038 Walker A/P-loop; other site 262316009039 ATP binding site [chemical binding]; other site 262316009040 Q-loop/lid; other site 262316009041 ABC transporter signature motif; other site 262316009042 Walker B; other site 262316009043 D-loop; other site 262316009044 H-loop/switch region; other site 262316009045 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 262316009046 Enolase [Carbohydrate transport and metabolism]; Region: Eno; COG0148 262316009047 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 262316009048 dimer interface [polypeptide binding]; other site 262316009049 metal binding site [ion binding]; metal-binding site 262316009050 substrate binding pocket [chemical binding]; other site 262316009051 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316009052 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316009053 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 262316009054 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 262316009055 substrate binding pocket [chemical binding]; other site 262316009056 active site 262316009057 iron coordination sites [ion binding]; other site 262316009058 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316009059 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316009060 [2Fe-2S] cluster binding site [ion binding]; other site 262316009061 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 262316009062 alpha subunit interface [polypeptide binding]; other site 262316009063 active site 262316009064 substrate binding site [chemical binding]; other site 262316009065 Fe binding site [ion binding]; other site 262316009066 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316009067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009068 NAD(P) binding site [chemical binding]; other site 262316009069 active site 262316009070 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 262316009071 phosphate binding motif [ion binding]; other site 262316009072 beta-alpha-beta structure motif; other site 262316009073 NAD binding pocket [chemical binding]; other site 262316009074 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 262316009075 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316009076 catalytic loop [active] 262316009077 iron binding site [ion binding]; other site 262316009078 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316009079 MarR family; Region: MarR_2; pfam12802 262316009080 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316009081 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 262316009082 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 262316009083 active site 262316009084 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316009085 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316009086 [2Fe-2S] cluster binding site [ion binding]; other site 262316009087 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 262316009088 alpha subunit interface [polypeptide binding]; other site 262316009089 active site 262316009090 substrate binding site [chemical binding]; other site 262316009091 Fe binding site [ion binding]; other site 262316009092 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316009093 NAD(P) binding site [chemical binding]; other site 262316009094 catalytic residues [active] 262316009095 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316009096 Fic/DOC family; Region: Fic; cl00960 262316009097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316009099 putative substrate translocation pore; other site 262316009100 phosphoglucomutase; Validated; Region: PRK07564 262316009101 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 262316009102 active site 262316009103 substrate binding site [chemical binding]; other site 262316009104 metal binding site [ion binding]; metal-binding site 262316009105 camphor resistance protein CrcB; Provisional; Region: PRK14216 262316009106 camphor resistance protein CrcB; Provisional; Region: PRK14228 262316009107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 262316009108 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 262316009109 Uncharacterized conserved protein [Function unknown]; Region: COG3189 262316009110 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316009111 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316009112 active site 262316009113 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 262316009114 Hemerythrin-like domain; Region: Hr-like; cd12108 262316009115 Fe binding site [ion binding]; other site 262316009116 Uncharacterized conserved protein [Function unknown]; Region: COG0397 262316009117 hypothetical protein; Validated; Region: PRK00029 262316009118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009119 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 262316009120 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316009121 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 262316009122 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 262316009123 putative active site [active] 262316009124 catalytic site [active] 262316009125 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 262316009126 putative active site [active] 262316009127 catalytic site [active] 262316009128 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 262316009129 Beta-lactamase; Region: Beta-lactamase; cl17358 262316009130 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 262316009131 Beta-lactamase; Region: Beta-lactamase; pfam00144 262316009132 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 262316009133 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 262316009134 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 262316009135 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316009136 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316009137 homodimer interface [polypeptide binding]; other site 262316009138 active site 262316009139 TDP-binding site; other site 262316009140 acceptor substrate-binding pocket; other site 262316009141 Methyltransferase domain; Region: Methyltransf_24; pfam13578 262316009142 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 262316009143 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 262316009144 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 262316009145 SmpB-tmRNA interface; other site 262316009146 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 262316009147 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 262316009148 FtsX-like permease family; Region: FtsX; pfam02687 262316009149 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 262316009150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316009151 Walker A/P-loop; other site 262316009152 ATP binding site [chemical binding]; other site 262316009153 Q-loop/lid; other site 262316009154 ABC transporter signature motif; other site 262316009155 Walker B; other site 262316009156 D-loop; other site 262316009157 H-loop/switch region; other site 262316009158 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 262316009159 Mechanosensitive ion channel; Region: MS_channel; pfam00924 262316009160 peptide chain release factor 2; Validated; Region: prfB; PRK00578 262316009161 This domain is found in peptide chain release factors; Region: PCRF; smart00937 262316009162 RF-1 domain; Region: RF-1; pfam00472 262316009163 ferredoxin-NADP+ reductase; Region: PLN02852 262316009164 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 262316009165 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 262316009166 heme-binding site [chemical binding]; other site 262316009167 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 262316009168 Ligand Binding Site [chemical binding]; other site 262316009169 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 262316009170 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 262316009171 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 262316009172 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 262316009173 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 262316009174 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316009175 PPE family; Region: PPE; pfam00823 262316009176 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316009177 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316009178 PPE family; Region: PPE; pfam00823 262316009179 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 262316009180 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 262316009181 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 262316009182 active site 262316009183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009185 active site 262316009186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009187 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009188 active site 262316009189 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262316009190 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 262316009191 NAD(P) binding site [chemical binding]; other site 262316009192 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 262316009193 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 262316009194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316009195 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262316009196 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316009197 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316009198 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316009199 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 262316009200 active site 262316009201 catalytic residues [active] 262316009202 metal binding site [ion binding]; metal-binding site 262316009203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009205 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009206 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316009207 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 262316009208 active site 262316009209 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 262316009210 Phosphotransferase enzyme family; Region: APH; pfam01636 262316009211 putative active site [active] 262316009212 ATP binding site [chemical binding]; other site 262316009213 putative substrate binding site [chemical binding]; other site 262316009214 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009215 YceI-like domain; Region: YceI; pfam04264 262316009216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 262316009217 phosphorylation site [posttranslational modification] 262316009218 intermolecular recognition site; other site 262316009219 NADH dehydrogenase subunit A; Validated; Region: PRK07928 262316009220 NADH dehydrogenase subunit B; Validated; Region: PRK06411 262316009221 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 262316009222 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 262316009223 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 262316009224 NADH dehydrogenase subunit D; Validated; Region: PRK06075 262316009225 NADH dehydrogenase subunit E; Validated; Region: PRK07539 262316009226 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 262316009227 putative dimer interface [polypeptide binding]; other site 262316009228 [2Fe-2S] cluster binding site [ion binding]; other site 262316009229 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 262316009230 SLBB domain; Region: SLBB; pfam10531 262316009231 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 262316009232 NADH dehydrogenase subunit G; Validated; Region: PRK07860 262316009233 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316009234 catalytic loop [active] 262316009235 iron binding site [ion binding]; other site 262316009236 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 262316009237 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316009238 molybdopterin cofactor binding site; other site 262316009239 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 262316009240 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 262316009241 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 262316009242 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 262316009243 4Fe-4S binding domain; Region: Fer4; pfam00037 262316009244 4Fe-4S binding domain; Region: Fer4; pfam00037 262316009245 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 262316009246 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 262316009247 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 262316009248 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 262316009249 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 262316009250 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 262316009251 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 262316009252 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 262316009253 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 262316009254 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 262316009255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009256 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316009257 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 262316009258 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 262316009259 Protein of unknown function DUF58; Region: DUF58; pfam01882 262316009260 MoxR-like ATPases [General function prediction only]; Region: COG0714 262316009261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316009262 Walker A motif; other site 262316009263 ATP binding site [chemical binding]; other site 262316009264 Walker B motif; other site 262316009265 arginine finger; other site 262316009266 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 262316009267 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316009268 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316009269 active site 262316009270 classical (c) SDRs; Region: SDR_c; cd05233 262316009271 NAD(P) binding site [chemical binding]; other site 262316009272 active site 262316009273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009275 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 262316009276 putative active site [active] 262316009277 putative substrate binding site [chemical binding]; other site 262316009278 ATP binding site [chemical binding]; other site 262316009279 Phosphotransferase enzyme family; Region: APH; pfam01636 262316009280 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 262316009281 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 262316009282 active site 262316009283 non-prolyl cis peptide bond; other site 262316009284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009285 metabolite-proton symporter; Region: 2A0106; TIGR00883 262316009286 putative substrate translocation pore; other site 262316009287 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 262316009288 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316009289 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316009290 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316009291 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 262316009292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316009293 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 262316009294 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316009295 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262316009296 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316009297 CheB methylesterase; Region: CheB_methylest; pfam01339 262316009298 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 262316009299 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 262316009300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316009301 S-adenosylmethionine binding site [chemical binding]; other site 262316009302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316009303 PAS domain; Region: PAS_9; pfam13426 262316009304 putative active site [active] 262316009305 heme pocket [chemical binding]; other site 262316009306 PAS domain; Region: PAS; smart00091 262316009307 PAS domain; Region: PAS_9; pfam13426 262316009308 putative active site [active] 262316009309 heme pocket [chemical binding]; other site 262316009310 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316009311 anti sigma factor interaction site; other site 262316009312 regulatory phosphorylation site [posttranslational modification]; other site 262316009313 CheB methylesterase; Region: CheB_methylest; pfam01339 262316009314 hydroperoxidase II; Provisional; Region: katE; PRK11249 262316009315 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 262316009316 tetramer interface [polypeptide binding]; other site 262316009317 heme binding pocket [chemical binding]; other site 262316009318 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 262316009319 domain interactions; other site 262316009320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009321 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316009322 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 262316009323 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 262316009324 putative metal binding site [ion binding]; other site 262316009325 putative metal binding site [ion binding]; other site 262316009326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009327 NADH(P)-binding; Region: NAD_binding_10; pfam13460 262316009328 NAD(P) binding site [chemical binding]; other site 262316009329 active site 262316009330 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 262316009331 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 262316009332 active site 262316009333 DNA binding site [nucleotide binding] 262316009334 Int/Topo IB signature motif; other site 262316009335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316009336 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 262316009337 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316009338 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 262316009339 putative ADP-binding pocket [chemical binding]; other site 262316009340 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316009341 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316009342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316009343 NAD(P) binding site [chemical binding]; other site 262316009344 active site 262316009345 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 262316009346 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 262316009347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316009348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316009349 active site 262316009350 motif I; other site 262316009351 motif II; other site 262316009352 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 262316009353 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 262316009354 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 262316009355 putative active site [active] 262316009356 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 262316009357 substrate binding site [chemical binding]; other site 262316009358 ATP binding site [chemical binding]; other site 262316009359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262316009360 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 262316009361 active site 262316009362 nucleotide binding site [chemical binding]; other site 262316009363 HIGH motif; other site 262316009364 KMSKS motif; other site 262316009365 classical (c) SDRs; Region: SDR_c; cd05233 262316009366 NAD(P) binding site [chemical binding]; other site 262316009367 active site 262316009368 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 262316009369 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316009370 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262316009371 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 262316009372 thiamine pyrophosphate protein; Provisional; Region: PRK08273 262316009373 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 262316009374 PYR/PP interface [polypeptide binding]; other site 262316009375 dimer interface [polypeptide binding]; other site 262316009376 tetramer interface [polypeptide binding]; other site 262316009377 TPP binding site [chemical binding]; other site 262316009378 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316009379 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 262316009380 TPP-binding site [chemical binding]; other site 262316009381 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 262316009382 Fe-S cluster binding site [ion binding]; other site 262316009383 active site 262316009384 Hemerythrin-like domain; Region: Hr-like; cd12108 262316009385 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 262316009386 PknH-like extracellular domain; Region: PknH_C; pfam14032 262316009387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316009388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316009389 active site 262316009390 catalytic tetrad [active] 262316009391 classical (c) SDRs; Region: SDR_c; cd05233 262316009392 NAD(P) binding site [chemical binding]; other site 262316009393 active site 262316009394 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 262316009395 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 262316009396 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 262316009397 active site 262316009398 catalytic site [active] 262316009399 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 262316009400 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316009401 NAD binding site [chemical binding]; other site 262316009402 catalytic Zn binding site [ion binding]; other site 262316009403 structural Zn binding site [ion binding]; other site 262316009404 GAF domain; Region: GAF; pfam01590 262316009405 GAF domain; Region: GAF_2; pfam13185 262316009406 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 262316009407 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316009408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316009409 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 262316009410 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 262316009411 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316009412 DNA binding residues [nucleotide binding] 262316009413 putative dimer interface [polypeptide binding]; other site 262316009414 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 262316009415 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 262316009416 putative dimer interface [polypeptide binding]; other site 262316009417 PAS fold; Region: PAS_3; pfam08447 262316009418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 262316009419 putative active site [active] 262316009420 heme pocket [chemical binding]; other site 262316009421 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 262316009422 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316009423 GAF domain; Region: GAF; pfam01590 262316009424 GAF domain; Region: GAF_3; pfam13492 262316009425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 262316009426 Histidine kinase; Region: HisKA_3; pfam07730 262316009427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316009428 ATP binding site [chemical binding]; other site 262316009429 Mg2+ binding site [ion binding]; other site 262316009430 G-X-G motif; other site 262316009431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316009432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316009433 active site 262316009434 phosphorylation site [posttranslational modification] 262316009435 intermolecular recognition site; other site 262316009436 dimerization interface [polypeptide binding]; other site 262316009437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316009438 DNA binding residues [nucleotide binding] 262316009439 dimerization interface [polypeptide binding]; other site 262316009440 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 262316009441 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316009442 dimer interface [polypeptide binding]; other site 262316009443 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316009444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 262316009445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316009446 ATP binding site [chemical binding]; other site 262316009447 Mg2+ binding site [ion binding]; other site 262316009448 G-X-G motif; other site 262316009449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316009450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316009451 active site 262316009452 phosphorylation site [posttranslational modification] 262316009453 intermolecular recognition site; other site 262316009454 dimerization interface [polypeptide binding]; other site 262316009455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316009456 DNA binding residues [nucleotide binding] 262316009457 dimerization interface [polypeptide binding]; other site 262316009458 Acyltransferase family; Region: Acyl_transf_3; pfam01757 262316009459 yiaA/B two helix domain; Region: YiaAB; cl01759 262316009460 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 262316009461 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 262316009462 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 262316009463 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316009464 FMN-binding pocket [chemical binding]; other site 262316009465 flavin binding motif; other site 262316009466 phosphate binding motif [ion binding]; other site 262316009467 beta-alpha-beta structure motif; other site 262316009468 NAD binding pocket [chemical binding]; other site 262316009469 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316009470 catalytic loop [active] 262316009471 iron binding site [ion binding]; other site 262316009472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316009473 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316009474 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 262316009475 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 262316009476 acyl-CoA synthetase; Validated; Region: PRK05850 262316009477 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316009478 acyl-activating enzyme (AAE) consensus motif; other site 262316009479 active site 262316009480 thioester reductase domain; Region: Thioester-redct; TIGR01746 262316009481 Male sterility protein; Region: NAD_binding_4; pfam07993 262316009482 NAD(P) binding site [chemical binding]; other site 262316009483 active site 262316009484 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 262316009485 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 262316009486 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316009487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 262316009488 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316009489 short chain dehydrogenase; Provisional; Region: PRK06197 262316009490 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316009491 putative NAD(P) binding site [chemical binding]; other site 262316009492 active site 262316009493 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316009494 mce related protein; Region: MCE; pfam02470 262316009495 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316009496 hypothetical protein; Validated; Region: PRK00068 262316009497 Uncharacterized conserved protein [Function unknown]; Region: COG1615 262316009498 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 262316009499 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 262316009500 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262316009501 Uncharacterized conserved protein [Function unknown]; Region: COG5282 262316009502 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 262316009503 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 262316009504 ABC1 family; Region: ABC1; pfam03109 262316009505 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 262316009506 active site 262316009507 ATP binding site [chemical binding]; other site 262316009508 Transcription factor WhiB; Region: Whib; pfam02467 262316009509 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 262316009510 Part of AAA domain; Region: AAA_19; pfam13245 262316009511 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 262316009512 Family description; Region: UvrD_C_2; pfam13538 262316009513 HRDC domain; Region: HRDC; pfam00570 262316009514 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 262316009515 catalytic residues [active] 262316009516 Ion channel; Region: Ion_trans_2; pfam07885 262316009517 TrkA-N domain; Region: TrkA_N; pfam02254 262316009518 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 262316009519 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 262316009520 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 262316009521 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 262316009522 putative NADH binding site [chemical binding]; other site 262316009523 putative active site [active] 262316009524 nudix motif; other site 262316009525 putative metal binding site [ion binding]; other site 262316009526 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 262316009527 Part of AAA domain; Region: AAA_19; pfam13245 262316009528 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 262316009529 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 262316009530 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 262316009531 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 262316009532 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316009533 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316009534 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 262316009535 catalytic site [active] 262316009536 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 262316009537 DNA binding site [nucleotide binding] 262316009538 active site 262316009539 TIGR02569 family protein; Region: TIGR02569_actnb 262316009540 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 262316009541 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 262316009542 ATP binding site [chemical binding]; other site 262316009543 substrate interface [chemical binding]; other site 262316009544 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 262316009545 active site residue [active] 262316009546 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 262316009547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009549 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 262316009550 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 262316009551 dinuclear metal binding motif [ion binding]; other site 262316009552 helicase 45; Provisional; Region: PTZ00424 262316009553 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 262316009554 ATP binding site [chemical binding]; other site 262316009555 Mg++ binding site [ion binding]; other site 262316009556 motif III; other site 262316009557 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316009558 nucleotide binding region [chemical binding]; other site 262316009559 ATP-binding site [chemical binding]; other site 262316009560 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 262316009561 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 262316009562 P-loop; other site 262316009563 Magnesium ion binding site [ion binding]; other site 262316009564 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 262316009565 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 262316009566 Magnesium ion binding site [ion binding]; other site 262316009567 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316009568 catalytic core [active] 262316009569 isochorismate synthase DhbC; Validated; Region: PRK06923 262316009570 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 262316009571 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 262316009572 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 262316009573 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 262316009574 Transcription factor WhiB; Region: Whib; pfam02467 262316009575 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 262316009576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 262316009577 Histidine kinase; Region: HisKA_2; pfam07568 262316009578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316009579 ATP binding site [chemical binding]; other site 262316009580 Mg2+ binding site [ion binding]; other site 262316009581 G-X-G motif; other site 262316009582 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262316009583 carboxyltransferase (CT) interaction site; other site 262316009584 biotinylation site [posttranslational modification]; other site 262316009585 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 262316009586 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 262316009587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316009588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316009589 DNA binding residues [nucleotide binding] 262316009590 short chain dehydrogenase; Provisional; Region: PRK08278 262316009591 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 262316009592 NAD(P) binding site [chemical binding]; other site 262316009593 homodimer interface [polypeptide binding]; other site 262316009594 active site 262316009595 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316009596 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 262316009597 NAD(P) binding site [chemical binding]; other site 262316009598 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 262316009599 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 262316009600 classical (c) SDRs; Region: SDR_c; cd05233 262316009601 NAD(P) binding site [chemical binding]; other site 262316009602 active site 262316009603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316009604 classical (c) SDRs; Region: SDR_c; cd05233 262316009605 NAD(P) binding site [chemical binding]; other site 262316009606 active site 262316009607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009609 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316009610 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316009611 active site 262316009612 Uncharacterized conserved protein [Function unknown]; Region: COG2135 262316009613 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 262316009614 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 262316009615 hinge; other site 262316009616 active site 262316009617 Predicted GTPases [General function prediction only]; Region: COG1162 262316009618 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 262316009619 GTPase/Zn-binding domain interface [polypeptide binding]; other site 262316009620 GTP/Mg2+ binding site [chemical binding]; other site 262316009621 G4 box; other site 262316009622 G5 box; other site 262316009623 G1 box; other site 262316009624 Switch I region; other site 262316009625 G2 box; other site 262316009626 G3 box; other site 262316009627 Switch II region; other site 262316009628 Predicted transcriptional regulators [Transcription]; Region: COG1733 262316009629 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 262316009630 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 262316009631 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316009632 dimer interface [polypeptide binding]; other site 262316009633 active site 262316009634 Domain of unknown function DUF302; Region: DUF302; pfam03625 262316009635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009636 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 262316009637 DNA-binding interface [nucleotide binding]; DNA binding site 262316009638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009640 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 262316009641 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 262316009642 putative di-iron ligands [ion binding]; other site 262316009643 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 262316009644 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316009645 FAD binding pocket [chemical binding]; other site 262316009646 FAD binding motif [chemical binding]; other site 262316009647 phosphate binding motif [ion binding]; other site 262316009648 beta-alpha-beta structure motif; other site 262316009649 NAD binding pocket [chemical binding]; other site 262316009650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316009651 catalytic loop [active] 262316009652 iron binding site [ion binding]; other site 262316009653 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 262316009654 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316009655 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316009656 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 262316009657 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 262316009658 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 262316009659 TrkA-C domain; Region: TrkA_C; pfam02080 262316009660 Phospholipid methyltransferase; Region: PEMT; cl17370 262316009661 HD domain; Region: HD_5; pfam13487 262316009662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262316009663 Zn2+ binding site [ion binding]; other site 262316009664 Mg2+ binding site [ion binding]; other site 262316009665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316009666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316009667 DNA binding residues [nucleotide binding] 262316009668 dimerization interface [polypeptide binding]; other site 262316009669 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 262316009670 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 262316009671 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 262316009672 30S subunit binding site; other site 262316009673 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 262316009674 Transposase domain (DUF772); Region: DUF772; pfam05598 262316009675 lipoprotein LpqB; Provisional; Region: PRK13616 262316009676 Sporulation and spore germination; Region: Germane; pfam10646 262316009677 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 262316009678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316009679 dimerization interface [polypeptide binding]; other site 262316009680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316009681 dimer interface [polypeptide binding]; other site 262316009682 phosphorylation site [posttranslational modification] 262316009683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316009684 ATP binding site [chemical binding]; other site 262316009685 Mg2+ binding site [ion binding]; other site 262316009686 G-X-G motif; other site 262316009687 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316009688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316009689 active site 262316009690 phosphorylation site [posttranslational modification] 262316009691 intermolecular recognition site; other site 262316009692 dimerization interface [polypeptide binding]; other site 262316009693 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316009694 DNA binding site [nucleotide binding] 262316009695 thymidylate kinase; Validated; Region: PRK07933 262316009696 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 262316009697 Adenosylhomocysteinase; Provisional; Region: PTZ00075 262316009698 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 262316009699 homotetramer interface [polypeptide binding]; other site 262316009700 ligand binding site [chemical binding]; other site 262316009701 catalytic site [active] 262316009702 NAD binding site [chemical binding]; other site 262316009703 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 262316009704 Fatty acid desaturase; Region: FA_desaturase; pfam00487 262316009705 Di-iron ligands [ion binding]; other site 262316009706 amino acid transporter; Region: 2A0306; TIGR00909 262316009707 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 262316009708 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 262316009709 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 262316009710 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 262316009711 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 262316009712 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 262316009713 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 262316009714 active site 262316009715 substrate binding site [chemical binding]; other site 262316009716 metal binding site [ion binding]; metal-binding site 262316009717 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 262316009718 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 262316009719 Transcription factor WhiB; Region: Whib; pfam02467 262316009720 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 262316009721 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 262316009722 dimer interface [polypeptide binding]; other site 262316009723 phosphate binding site [ion binding]; other site 262316009724 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 262316009725 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 262316009726 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 262316009727 FMN binding site [chemical binding]; other site 262316009728 dimer interface [polypeptide binding]; other site 262316009729 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 262316009730 Methyltransferase domain; Region: Methyltransf_26; pfam13659 262316009731 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 262316009732 nudix motif; other site 262316009733 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 262316009734 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 262316009735 active site 262316009736 Substrate binding site; other site 262316009737 Mg++ binding site; other site 262316009738 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 262316009739 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 262316009740 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 262316009741 Probable Catalytic site; other site 262316009742 metal-binding site 262316009743 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 262316009744 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 262316009745 NADP binding site [chemical binding]; other site 262316009746 active site 262316009747 putative substrate binding site [chemical binding]; other site 262316009748 Transcriptional regulator [Transcription]; Region: LytR; COG1316 262316009749 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 262316009750 TIGR03089 family protein; Region: TIGR03089 262316009751 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 262316009752 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 262316009753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316009754 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316009755 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316009756 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316009757 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316009758 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316009759 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316009760 active site 262316009761 ATP binding site [chemical binding]; other site 262316009762 substrate binding site [chemical binding]; other site 262316009763 activation loop (A-loop); other site 262316009764 Uncharacterized conserved protein [Function unknown]; Region: COG3391 262316009765 NHL repeat; Region: NHL; pfam01436 262316009766 NHL repeat; Region: NHL; pfam01436 262316009767 NHL repeat; Region: NHL; pfam01436 262316009768 NHL repeat; Region: NHL; pfam01436 262316009769 PBP superfamily domain; Region: PBP_like_2; cl17296 262316009770 Response regulator receiver domain; Region: Response_reg; pfam00072 262316009771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316009772 active site 262316009773 phosphorylation site [posttranslational modification] 262316009774 intermolecular recognition site; other site 262316009775 dimerization interface [polypeptide binding]; other site 262316009776 CHASE3 domain; Region: CHASE3; pfam05227 262316009777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316009778 HAMP domain; Region: HAMP; pfam00672 262316009779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316009780 dimer interface [polypeptide binding]; other site 262316009781 phosphorylation site [posttranslational modification] 262316009782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316009783 ATP binding site [chemical binding]; other site 262316009784 Mg2+ binding site [ion binding]; other site 262316009785 G-X-G motif; other site 262316009786 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 262316009787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316009788 active site 262316009789 phosphorylation site [posttranslational modification] 262316009790 intermolecular recognition site; other site 262316009791 dimerization interface [polypeptide binding]; other site 262316009792 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 262316009793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316009794 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 262316009795 FAD binding site [chemical binding]; other site 262316009796 homotetramer interface [polypeptide binding]; other site 262316009797 substrate binding pocket [chemical binding]; other site 262316009798 catalytic base [active] 262316009799 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 262316009800 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 262316009801 ATP-grasp domain; Region: ATP-grasp; pfam02222 262316009802 Predicted membrane protein [Function unknown]; Region: COG2246 262316009803 GtrA-like protein; Region: GtrA; pfam04138 262316009804 Bacterial PH domain; Region: DUF304; pfam03703 262316009805 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 262316009806 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 262316009807 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 262316009808 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 262316009809 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262316009810 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 262316009811 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 262316009812 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 262316009813 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 262316009814 Maf-like protein; Region: Maf; pfam02545 262316009815 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 262316009816 active site 262316009817 dimer interface [polypeptide binding]; other site 262316009818 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 262316009819 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 262316009820 active site residue [active] 262316009821 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 262316009822 active site residue [active] 262316009823 Fe-S metabolism associated domain; Region: SufE; cl00951 262316009824 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 262316009825 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 262316009826 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 262316009827 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 262316009828 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 262316009829 carboxyltransferase (CT) interaction site; other site 262316009830 biotinylation site [posttranslational modification]; other site 262316009831 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316009832 anti sigma factor interaction site; other site 262316009833 regulatory phosphorylation site [posttranslational modification]; other site 262316009834 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 262316009835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316009836 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262316009837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316009838 DNA binding residues [nucleotide binding] 262316009839 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 262316009840 L-lysine aminotransferase; Provisional; Region: PRK08297 262316009841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262316009842 inhibitor-cofactor binding pocket; inhibition site 262316009843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316009844 catalytic residue [active] 262316009845 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 262316009846 AsnC family; Region: AsnC_trans_reg; pfam01037 262316009847 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 262316009848 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 262316009849 aldehyde dehydrogenase family 7 member; Region: PLN02315 262316009850 tetrameric interface [polypeptide binding]; other site 262316009851 NAD binding site [chemical binding]; other site 262316009852 catalytic residues [active] 262316009853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316009854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316009855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262316009856 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 262316009857 ATP binding site [chemical binding]; other site 262316009858 putative Mg++ binding site [ion binding]; other site 262316009859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262316009860 nucleotide binding region [chemical binding]; other site 262316009861 ATP-binding site [chemical binding]; other site 262316009862 DEAD/H associated; Region: DEAD_assoc; pfam08494 262316009863 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 262316009864 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 262316009865 putative DNA binding site [nucleotide binding]; other site 262316009866 catalytic residue [active] 262316009867 putative H2TH interface [polypeptide binding]; other site 262316009868 putative catalytic residues [active] 262316009869 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262316009870 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262316009871 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 262316009872 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316009873 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316009874 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316009875 PPE family; Region: PPE; pfam00823 262316009876 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316009877 PPE family; Region: PPE; pfam00823 262316009878 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 262316009879 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 262316009880 active site 262316009881 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 262316009882 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 262316009883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316009884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316009885 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316009886 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 262316009887 putative active site pocket [active] 262316009888 dimerization interface [polypeptide binding]; other site 262316009889 putative catalytic residue [active] 262316009890 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 262316009891 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 262316009892 metal binding site [ion binding]; metal-binding site 262316009893 putative dimer interface [polypeptide binding]; other site 262316009894 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 262316009895 amidohydrolase; Region: amidohydrolases; TIGR01891 262316009896 metal binding site [ion binding]; metal-binding site 262316009897 Cutinase; Region: Cutinase; pfam01083 262316009898 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262316009899 purine nucleoside phosphorylase; Provisional; Region: PRK08202 262316009900 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 262316009901 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 262316009902 active site 262316009903 substrate binding site [chemical binding]; other site 262316009904 metal binding site [ion binding]; metal-binding site 262316009905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316009906 active site 262316009907 Phosphoesterase family; Region: Phosphoesterase; pfam04185 262316009908 hypothetical protein; Provisional; Region: PRK13685 262316009909 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 262316009910 metal ion-dependent adhesion site (MIDAS); other site 262316009911 hypothetical protein; Provisional; Region: PRK13685 262316009912 von Willebrand factor type A domain; Region: VWA_2; pfam13519 262316009913 metal ion-dependent adhesion site (MIDAS); other site 262316009914 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316009915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316009916 non-specific DNA binding site [nucleotide binding]; other site 262316009917 salt bridge; other site 262316009918 sequence-specific DNA binding site [nucleotide binding]; other site 262316009919 adenosine deaminase; Provisional; Region: PRK09358 262316009920 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 262316009921 active site 262316009922 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 262316009923 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 262316009924 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 262316009925 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 262316009926 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 262316009927 active site 262316009928 catalytic motif [active] 262316009929 Zn binding site [ion binding]; other site 262316009930 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 262316009931 putative Iron-sulfur protein interface [polypeptide binding]; other site 262316009932 putative proximal heme binding site [chemical binding]; other site 262316009933 putative SdhD-like interface [polypeptide binding]; other site 262316009934 putative distal heme binding site [chemical binding]; other site 262316009935 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 262316009936 putative Iron-sulfur protein interface [polypeptide binding]; other site 262316009937 putative proximal heme binding site [chemical binding]; other site 262316009938 putative SdhC-like subunit interface [polypeptide binding]; other site 262316009939 putative distal heme binding site [chemical binding]; other site 262316009940 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 262316009941 L-aspartate oxidase; Provisional; Region: PRK06175 262316009942 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 262316009943 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 262316009944 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 262316009945 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316009946 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 262316009947 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 262316009948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316009949 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316009950 DNA binding residues [nucleotide binding] 262316009951 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 262316009952 hypothetical protein; Provisional; Region: PRK06541 262316009953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262316009954 inhibitor-cofactor binding pocket; inhibition site 262316009955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316009956 catalytic residue [active] 262316009957 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 262316009958 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 262316009959 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 262316009960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009961 putative substrate translocation pore; other site 262316009962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316009963 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 262316009964 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316009965 active site 262316009966 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 262316009967 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 262316009968 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 262316009969 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 262316009970 active site 262316009971 HIGH motif; other site 262316009972 dimer interface [polypeptide binding]; other site 262316009973 KMSKS motif; other site 262316009974 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316009975 isocitrate dehydrogenase; Validated; Region: PRK08299 262316009976 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 262316009977 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 262316009978 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 262316009979 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 262316009980 homodimer interface [polypeptide binding]; other site 262316009981 substrate-cofactor binding pocket; other site 262316009982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316009983 catalytic residue [active] 262316009984 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 262316009985 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 262316009986 Methyltransferase domain; Region: Methyltransf_23; pfam13489 262316009987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316009988 S-adenosylmethionine binding site [chemical binding]; other site 262316009989 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316009990 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316009991 active site 262316009992 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316009993 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 262316009994 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 262316009995 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 262316009996 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 262316009997 homodimer interface [polypeptide binding]; other site 262316009998 NADP binding site [chemical binding]; other site 262316009999 substrate binding site [chemical binding]; other site 262316010000 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 262316010001 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 262316010002 active site 262316010003 FMN binding site [chemical binding]; other site 262316010004 substrate binding site [chemical binding]; other site 262316010005 putative catalytic residue [active] 262316010006 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316010007 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316010008 phosphopeptide binding site; other site 262316010009 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316010010 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316010011 phosphopeptide binding site; other site 262316010012 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316010013 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 262316010014 Walker A/P-loop; other site 262316010015 ATP binding site [chemical binding]; other site 262316010016 Q-loop/lid; other site 262316010017 ABC transporter signature motif; other site 262316010018 Walker B; other site 262316010019 D-loop; other site 262316010020 H-loop/switch region; other site 262316010021 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316010022 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316010023 phosphopeptide binding site; other site 262316010024 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 262316010025 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 262316010026 phosphopeptide binding site; other site 262316010027 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316010028 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 262316010029 Walker A/P-loop; other site 262316010030 ATP binding site [chemical binding]; other site 262316010031 Q-loop/lid; other site 262316010032 ABC transporter signature motif; other site 262316010033 Walker B; other site 262316010034 D-loop; other site 262316010035 H-loop/switch region; other site 262316010036 ABC-2 type transporter; Region: ABC2_membrane; cl17235 262316010037 Transposase domain (DUF772); Region: DUF772; pfam05598 262316010038 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 262316010039 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 262316010040 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 262316010041 G1 box; other site 262316010042 GTP/Mg2+ binding site [chemical binding]; other site 262316010043 G2 box; other site 262316010044 Switch I region; other site 262316010045 G3 box; other site 262316010046 Switch II region; other site 262316010047 G4 box; other site 262316010048 G5 box; other site 262316010049 Protein of unknown function (DUF742); Region: DUF742; pfam05331 262316010050 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 262316010051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 262316010052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316010053 ATP binding site [chemical binding]; other site 262316010054 Mg2+ binding site [ion binding]; other site 262316010055 G-X-G motif; other site 262316010056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010057 S-adenosylmethionine binding site [chemical binding]; other site 262316010058 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 262316010059 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 262316010060 FMN binding site [chemical binding]; other site 262316010061 dimer interface [polypeptide binding]; other site 262316010062 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 262316010063 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 262316010064 active site 262316010065 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 262316010066 generic binding surface II; other site 262316010067 generic binding surface I; other site 262316010068 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316010069 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 262316010070 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 262316010071 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316010072 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 262316010073 dimer interaction site [polypeptide binding]; other site 262316010074 substrate-binding tunnel; other site 262316010075 active site 262316010076 catalytic site [active] 262316010077 substrate binding site [chemical binding]; other site 262316010078 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316010079 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316010080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316010081 catalytic core [active] 262316010082 short chain dehydrogenase; Provisional; Region: PRK07201 262316010083 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 262316010084 putative NAD(P) binding site [chemical binding]; other site 262316010085 active site 262316010086 putative substrate binding site [chemical binding]; other site 262316010087 classical (c) SDRs; Region: SDR_c; cd05233 262316010088 NAD(P) binding site [chemical binding]; other site 262316010089 active site 262316010090 Biofilm formation and stress response factor; Region: BsmA; cl01794 262316010091 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 262316010092 active site 262316010093 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 262316010094 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 262316010095 dimer interface [polypeptide binding]; other site 262316010096 active site 262316010097 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 262316010098 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 262316010099 putative active site [active] 262316010100 putative substrate binding site [chemical binding]; other site 262316010101 putative FMN binding site [chemical binding]; other site 262316010102 putative catalytic residues [active] 262316010103 Y-family of DNA polymerases; Region: PolY; cl12025 262316010104 DNA binding site [nucleotide binding] 262316010105 GMP synthase; Reviewed; Region: guaA; PRK00074 262316010106 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 262316010107 AMP/PPi binding site [chemical binding]; other site 262316010108 candidate oxyanion hole; other site 262316010109 catalytic triad [active] 262316010110 potential glutamine specificity residues [chemical binding]; other site 262316010111 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 262316010112 ATP Binding subdomain [chemical binding]; other site 262316010113 Ligand Binding sites [chemical binding]; other site 262316010114 Dimerization subdomain; other site 262316010115 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316010116 PPE family; Region: PPE; pfam00823 262316010117 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 262316010118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316010119 motif II; other site 262316010120 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 262316010121 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 262316010122 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 262316010123 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 262316010124 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 262316010125 NAD(P) binding site [chemical binding]; other site 262316010126 catalytic residues [active] 262316010127 Cutinase; Region: Cutinase; pfam01083 262316010128 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 262316010129 classical (c) SDRs; Region: SDR_c; cd05233 262316010130 NAD(P) binding site [chemical binding]; other site 262316010131 active site 262316010132 acyl-CoA synthetase; Provisional; Region: PRK13383 262316010133 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010134 acyl-activating enzyme (AAE) consensus motif; other site 262316010135 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010136 AMP binding site [chemical binding]; other site 262316010137 active site 262316010138 acyl-activating enzyme (AAE) consensus motif; other site 262316010139 CoA binding site [chemical binding]; other site 262316010140 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316010141 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 262316010142 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 262316010143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316010144 motif II; other site 262316010145 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 262316010146 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316010147 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 262316010148 hydrophobic ligand binding site; other site 262316010149 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 262316010150 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 262316010151 NAD binding site [chemical binding]; other site 262316010152 catalytic Zn binding site [ion binding]; other site 262316010153 substrate binding site [chemical binding]; other site 262316010154 structural Zn binding site [ion binding]; other site 262316010155 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 262316010156 classical (c) SDRs; Region: SDR_c; cd05233 262316010157 NAD(P) binding site [chemical binding]; other site 262316010158 active site 262316010159 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 262316010160 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316010161 acyl-activating enzyme (AAE) consensus motif; other site 262316010162 putative AMP binding site [chemical binding]; other site 262316010163 putative active site [active] 262316010164 putative CoA binding site [chemical binding]; other site 262316010165 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 262316010166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316010167 DNA-binding site [nucleotide binding]; DNA binding site 262316010168 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 262316010169 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 262316010170 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 262316010171 classical (c) SDRs; Region: SDR_c; cd05233 262316010172 NAD(P) binding site [chemical binding]; other site 262316010173 active site 262316010174 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316010175 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316010176 [2Fe-2S] cluster binding site [ion binding]; other site 262316010177 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 262316010178 putative alpha subunit interface [polypeptide binding]; other site 262316010179 putative active site [active] 262316010180 putative substrate binding site [chemical binding]; other site 262316010181 Fe binding site [ion binding]; other site 262316010182 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316010183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316010184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010185 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316010186 NAD(P) binding site [chemical binding]; other site 262316010187 active site 262316010188 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316010189 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316010190 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 262316010191 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316010192 PYR/PP interface [polypeptide binding]; other site 262316010193 dimer interface [polypeptide binding]; other site 262316010194 TPP binding site [chemical binding]; other site 262316010195 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316010196 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 262316010197 TPP-binding site; other site 262316010198 dimer interface [polypeptide binding]; other site 262316010199 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 262316010200 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316010201 NAD binding site [chemical binding]; other site 262316010202 catalytic residues [active] 262316010203 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316010204 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 262316010205 active site 262316010206 catalytic triad [active] 262316010207 oxyanion hole [active] 262316010208 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316010209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010210 S-adenosylmethionine binding site [chemical binding]; other site 262316010211 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 262316010212 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 262316010213 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 262316010214 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 262316010215 putative NAD(P) binding site [chemical binding]; other site 262316010216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316010217 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 262316010218 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316010219 Isochorismatase family; Region: Isochorismatase; pfam00857 262316010220 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 262316010221 catalytic triad [active] 262316010222 conserved cis-peptide bond; other site 262316010223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316010224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316010225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262316010226 dimerization interface [polypeptide binding]; other site 262316010227 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 262316010228 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316010229 PYR/PP interface [polypeptide binding]; other site 262316010230 dimer interface [polypeptide binding]; other site 262316010231 TPP binding site [chemical binding]; other site 262316010232 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316010233 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 262316010234 TPP-binding site; other site 262316010235 dimer interface [polypeptide binding]; other site 262316010236 acyl-CoA synthetase; Validated; Region: PRK05852 262316010237 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010238 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 262316010239 acyl-activating enzyme (AAE) consensus motif; other site 262316010240 acyl-activating enzyme (AAE) consensus motif; other site 262316010241 putative AMP binding site [chemical binding]; other site 262316010242 putative active site [active] 262316010243 putative CoA binding site [chemical binding]; other site 262316010244 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 262316010245 elongation factor G; Reviewed; Region: PRK12740 262316010246 G1 box; other site 262316010247 putative GEF interaction site [polypeptide binding]; other site 262316010248 GTP/Mg2+ binding site [chemical binding]; other site 262316010249 Switch I region; other site 262316010250 G2 box; other site 262316010251 G3 box; other site 262316010252 Switch II region; other site 262316010253 G4 box; other site 262316010254 G5 box; other site 262316010255 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 262316010256 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 262316010257 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 262316010258 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 262316010259 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 262316010260 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262316010261 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 262316010262 trehalose synthase; Region: treS_nterm; TIGR02456 262316010263 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 262316010264 active site 262316010265 catalytic site [active] 262316010266 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 262316010267 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 262316010268 Predicted membrane protein [Function unknown]; Region: COG3619 262316010269 Putative esterase; Region: Esterase; pfam00756 262316010270 ABC-2 type transporter; Region: ABC2_membrane; cl17235 262316010271 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 262316010272 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 262316010273 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265 262316010274 Walker A/P-loop; other site 262316010275 ATP binding site [chemical binding]; other site 262316010276 Q-loop/lid; other site 262316010277 ABC transporter signature motif; other site 262316010278 Walker B; other site 262316010279 D-loop; other site 262316010280 H-loop/switch region; other site 262316010281 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 262316010282 active site 262316010283 metal binding site [ion binding]; metal-binding site 262316010284 homotetramer interface [polypeptide binding]; other site 262316010285 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 262316010286 putative homodimer interface [polypeptide binding]; other site 262316010287 putative homotetramer interface [polypeptide binding]; other site 262316010288 putative allosteric switch controlling residues; other site 262316010289 putative metal binding site [ion binding]; other site 262316010290 putative homodimer-homodimer interface [polypeptide binding]; other site 262316010291 Domain of unknown function DUF302; Region: DUF302; pfam03625 262316010292 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316010293 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316010294 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 262316010295 TAP-like protein; Region: Abhydrolase_4; pfam08386 262316010296 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 262316010297 putative active site [active] 262316010298 putative catalytic site [active] 262316010299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010300 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010301 active site 262316010302 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 262316010303 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 262316010304 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316010305 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316010306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 262316010307 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 262316010308 Coenzyme A binding pocket [chemical binding]; other site 262316010309 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 262316010310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010311 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 262316010312 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 262316010313 FAD binding pocket [chemical binding]; other site 262316010314 FAD binding motif [chemical binding]; other site 262316010315 phosphate binding motif [ion binding]; other site 262316010316 beta-alpha-beta structure motif; other site 262316010317 NAD binding pocket [chemical binding]; other site 262316010318 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316010319 catalytic loop [active] 262316010320 iron binding site [ion binding]; other site 262316010321 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 262316010322 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 262316010323 putative di-iron ligands [ion binding]; other site 262316010324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316010327 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 262316010328 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 262316010329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010331 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316010332 Cytochrome P450; Region: p450; cl12078 262316010333 methionine sulfoxide reductase A; Provisional; Region: PRK14054 262316010334 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316010335 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 262316010336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010337 NAD(P) binding site [chemical binding]; other site 262316010338 active site 262316010339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 262316010340 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 262316010341 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 262316010342 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 262316010343 minor groove reading motif; other site 262316010344 helix-hairpin-helix signature motif; other site 262316010345 active site 262316010346 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 262316010347 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 262316010348 dimerization interface [polypeptide binding]; other site 262316010349 DPS ferroxidase diiron center [ion binding]; other site 262316010350 ion pore; other site 262316010351 Pirin-related protein [General function prediction only]; Region: COG1741 262316010352 Pirin; Region: Pirin; pfam02678 262316010353 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 262316010354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010356 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316010357 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316010358 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316010359 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316010360 Transcriptional regulator [Transcription]; Region: LytR; COG1316 262316010361 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 262316010362 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 262316010363 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 262316010364 NAD(P) binding site [chemical binding]; other site 262316010365 catalytic residues [active] 262316010366 short chain dehydrogenase; Provisional; Region: PRK07791 262316010367 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 262316010368 NAD binding site [chemical binding]; other site 262316010369 homodimer interface [polypeptide binding]; other site 262316010370 active site 262316010371 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 262316010372 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 262316010373 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 262316010374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010376 active site 262316010377 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316010378 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 262316010379 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 262316010380 ligand binding site [chemical binding]; other site 262316010381 homodimer interface [polypeptide binding]; other site 262316010382 NAD(P) binding site [chemical binding]; other site 262316010383 trimer interface B [polypeptide binding]; other site 262316010384 trimer interface A [polypeptide binding]; other site 262316010385 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 262316010386 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 262316010387 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 262316010388 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 262316010389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010391 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316010392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316010394 NAD(P) binding site [chemical binding]; other site 262316010395 active site 262316010396 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 262316010397 FAD binding domain; Region: FAD_binding_4; pfam01565 262316010398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010400 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 262316010401 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 262316010402 Strictosidine synthase; Region: Str_synth; pfam03088 262316010403 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 262316010404 hydrophobic ligand binding site; other site 262316010405 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 262316010406 acyl-CoA thioesterase II; Region: tesB; TIGR00189 262316010407 active site 262316010408 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 262316010409 catalytic triad [active] 262316010410 dimer interface [polypeptide binding]; other site 262316010411 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316010412 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 262316010413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010415 active site 262316010416 Domain of unknown function (DUF427); Region: DUF427; pfam04248 262316010417 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316010418 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316010419 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316010420 Cytochrome P450; Region: p450; cl12078 262316010421 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 262316010422 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316010423 putative NAD(P) binding site [chemical binding]; other site 262316010424 catalytic Zn binding site [ion binding]; other site 262316010425 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 262316010426 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 262316010427 classical (c) SDRs; Region: SDR_c; cd05233 262316010428 NAD(P) binding site [chemical binding]; other site 262316010429 active site 262316010430 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316010431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316010432 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316010433 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316010434 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 262316010435 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 262316010436 NAD(P) binding site [chemical binding]; other site 262316010437 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 262316010438 active site 262316010439 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 262316010440 putative hydrophobic ligand binding site [chemical binding]; other site 262316010441 Transcriptional regulators [Transcription]; Region: GntR; COG1802 262316010442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316010443 DNA-binding site [nucleotide binding]; DNA binding site 262316010444 FCD domain; Region: FCD; pfam07729 262316010445 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010446 AMP-binding enzyme; Region: AMP-binding; pfam00501 262316010447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010448 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 262316010449 acyl-activating enzyme (AAE) consensus motif; other site 262316010450 acyl-activating enzyme (AAE) consensus motif; other site 262316010451 putative AMP binding site [chemical binding]; other site 262316010452 putative active site [active] 262316010453 putative CoA binding site [chemical binding]; other site 262316010454 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316010455 Permease; Region: Permease; pfam02405 262316010456 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316010457 Permease; Region: Permease; pfam02405 262316010458 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010459 mce related protein; Region: MCE; pfam02470 262316010460 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316010461 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010462 mce related protein; Region: MCE; pfam02470 262316010463 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316010464 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010465 mce related protein; Region: MCE; pfam02470 262316010466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 262316010467 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010468 mce related protein; Region: MCE; pfam02470 262316010469 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010470 mce related protein; Region: MCE; pfam02470 262316010471 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316010472 mce related protein; Region: MCE; pfam02470 262316010473 RDD family; Region: RDD; pfam06271 262316010474 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 262316010475 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 262316010476 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 262316010477 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 262316010478 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 262316010479 Pirin; Region: Pirin; pfam02678 262316010480 Pirin-related protein [General function prediction only]; Region: COG1741 262316010481 Transcriptional regulator [Transcription]; Region: IclR; COG1414 262316010482 Bacterial transcriptional regulator; Region: IclR; pfam01614 262316010483 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 262316010484 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 262316010485 RNA polymerase factor sigma-70; Validated; Region: PRK08241 262316010486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316010487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316010488 DNA binding residues [nucleotide binding] 262316010489 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316010490 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 262316010491 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316010492 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 262316010493 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 262316010494 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 262316010495 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 262316010496 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 262316010497 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 262316010498 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 262316010499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010500 S-adenosylmethionine binding site [chemical binding]; other site 262316010501 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 262316010502 FMN binding site [chemical binding]; other site 262316010503 substrate binding site [chemical binding]; other site 262316010504 putative catalytic residue [active] 262316010505 SPW repeat; Region: SPW; pfam03779 262316010506 SPW repeat; Region: SPW; pfam03779 262316010507 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 262316010508 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 262316010509 putative homodimer interface [polypeptide binding]; other site 262316010510 putative homotetramer interface [polypeptide binding]; other site 262316010511 putative allosteric switch controlling residues; other site 262316010512 putative metal binding site [ion binding]; other site 262316010513 putative homodimer-homodimer interface [polypeptide binding]; other site 262316010514 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 262316010515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316010516 putative substrate translocation pore; other site 262316010517 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 262316010518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316010519 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316010520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010522 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 262316010523 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316010524 molybdopterin cofactor binding site; other site 262316010525 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 262316010526 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 262316010527 molybdopterin cofactor binding site; other site 262316010528 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316010529 Predicted integral membrane protein [Function unknown]; Region: COG0392 262316010530 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 262316010531 Domain of unknown function DUF20; Region: UPF0118; pfam01594 262316010532 MMPL family; Region: MMPL; pfam03176 262316010533 MMPL family; Region: MMPL; pfam03176 262316010534 LabA_like proteins; Region: LabA_like; cd06167 262316010535 putative metal binding site [ion binding]; other site 262316010536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262316010537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010538 S-adenosylmethionine binding site [chemical binding]; other site 262316010539 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 262316010540 active site 262316010541 substrate-binding site [chemical binding]; other site 262316010542 metal-binding site [ion binding] 262316010543 GTP binding site [chemical binding]; other site 262316010544 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 262316010545 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 262316010546 metal binding site [ion binding]; metal-binding site 262316010547 active site 262316010548 I-site; other site 262316010549 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316010550 GAF domain; Region: GAF; pfam01590 262316010551 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 262316010552 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010553 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 262316010554 acyl-activating enzyme (AAE) consensus motif; other site 262316010555 acyl-activating enzyme (AAE) consensus motif; other site 262316010556 putative AMP binding site [chemical binding]; other site 262316010557 putative active site [active] 262316010558 putative CoA binding site [chemical binding]; other site 262316010559 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316010560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316010561 substrate binding site [chemical binding]; other site 262316010562 oxyanion hole (OAH) forming residues; other site 262316010563 trimer interface [polypeptide binding]; other site 262316010564 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010566 active site 262316010567 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316010568 active site 2 [active] 262316010569 active site 1 [active] 262316010570 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 262316010571 putative active site [active] 262316010572 putative catalytic site [active] 262316010573 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316010574 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316010575 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316010576 active site 262316010577 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 262316010578 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316010579 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 262316010580 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316010581 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 262316010582 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 262316010583 enoyl-CoA hydratase; Provisional; Region: PRK08252 262316010584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316010585 substrate binding site [chemical binding]; other site 262316010586 oxyanion hole (OAH) forming residues; other site 262316010587 trimer interface [polypeptide binding]; other site 262316010588 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 262316010589 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010590 acyl-activating enzyme (AAE) consensus motif; other site 262316010591 AMP binding site [chemical binding]; other site 262316010592 active site 262316010593 CoA binding site [chemical binding]; other site 262316010594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010596 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 262316010597 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316010598 NAD binding site [chemical binding]; other site 262316010599 catalytic residues [active] 262316010600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010601 S-adenosylmethionine binding site [chemical binding]; other site 262316010602 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 262316010603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316010604 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 262316010605 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316010606 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 262316010607 active site 262316010608 substrate binding pocket [chemical binding]; other site 262316010609 homodimer interaction site [polypeptide binding]; other site 262316010610 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010611 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010612 active site 262316010613 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 262316010614 Winged helix-turn helix; Region: HTH_29; pfam13551 262316010615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 262316010616 Integrase core domain; Region: rve; pfam00665 262316010617 Integrase core domain; Region: rve_3; pfam13683 262316010618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010620 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 262316010621 active site 262316010622 diiron metal binding site [ion binding]; other site 262316010623 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 262316010624 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 262316010625 NAD(P) binding site [chemical binding]; other site 262316010626 catalytic residues [active] 262316010627 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 262316010628 acetolactate synthase; Reviewed; Region: PRK08322 262316010629 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316010630 dimer interface [polypeptide binding]; other site 262316010631 PYR/PP interface [polypeptide binding]; other site 262316010632 TPP binding site [chemical binding]; other site 262316010633 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262316010634 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 262316010635 TPP-binding site [chemical binding]; other site 262316010636 dimer interface [polypeptide binding]; other site 262316010637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 262316010638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 262316010639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 262316010640 dimerization interface [polypeptide binding]; other site 262316010641 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 262316010642 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316010643 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316010644 active site 262316010645 metal binding site [ion binding]; metal-binding site 262316010646 Predicted membrane protein [Function unknown]; Region: COG4129 262316010647 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 262316010648 formate dehydrogenase; Provisional; Region: PRK07574 262316010649 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 262316010650 NAD binding site [chemical binding]; other site 262316010651 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 262316010652 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 262316010653 heme binding pocket [chemical binding]; other site 262316010654 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 262316010655 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 262316010656 heme binding pocket [chemical binding]; other site 262316010657 choline dehydrogenase; Validated; Region: PRK02106 262316010658 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316010659 Lipase maturation factor; Region: LMF1; pfam06762 262316010660 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 262316010661 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 262316010662 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 262316010663 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 262316010664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010666 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 262316010667 putative ion selectivity filter; other site 262316010668 putative pore gating glutamate residue; other site 262316010669 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316010670 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316010671 active site 2 [active] 262316010672 active site 1 [active] 262316010673 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 262316010674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010675 NAD(P) binding site [chemical binding]; other site 262316010676 active site 262316010677 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 262316010678 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 262316010679 dimer interface [polypeptide binding]; other site 262316010680 active site 262316010681 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 262316010682 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 262316010683 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 262316010684 FAD binding site [chemical binding]; other site 262316010685 substrate binding site [chemical binding]; other site 262316010686 catalytic residues [active] 262316010687 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 262316010688 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 262316010689 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 262316010690 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 262316010691 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 262316010692 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 262316010693 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 262316010694 catalytic loop [active] 262316010695 iron binding site [ion binding]; other site 262316010696 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 262316010697 L-aspartate oxidase; Provisional; Region: PRK06175 262316010698 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 262316010699 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 262316010700 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 262316010701 putative dimer interface [polypeptide binding]; other site 262316010702 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 262316010703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316010704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316010705 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 262316010706 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 262316010707 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 262316010708 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 262316010709 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 262316010710 putative active site [active] 262316010711 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 262316010712 putative active site [active] 262316010713 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 262316010714 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 262316010715 active site 262316010716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 262316010717 DNA binding site [nucleotide binding] 262316010718 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 262316010719 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 262316010720 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 262316010721 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 262316010722 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 262316010723 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 262316010724 intersubunit interface [polypeptide binding]; other site 262316010725 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316010726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010727 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 262316010728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316010729 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 262316010730 nucleotide binding site [chemical binding]; other site 262316010731 acyl-CoA synthetase; Validated; Region: PRK07788 262316010732 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010733 acyl-activating enzyme (AAE) consensus motif; other site 262316010734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010735 active site 262316010736 CoA binding site [chemical binding]; other site 262316010737 AMP binding site [chemical binding]; other site 262316010738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010739 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316010740 active site 262316010741 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316010742 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 262316010743 FAD binding site [chemical binding]; other site 262316010744 substrate binding site [chemical binding]; other site 262316010745 catalytic base [active] 262316010746 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316010747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010748 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 262316010749 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316010750 Zn binding site [ion binding]; other site 262316010751 Condensation domain; Region: Condensation; pfam00668 262316010752 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 262316010753 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316010754 PPE family; Region: PPE; pfam00823 262316010755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262316010756 dimer interface [polypeptide binding]; other site 262316010757 putative PBP binding regions; other site 262316010758 ABC-ATPase subunit interface; other site 262316010759 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 262316010760 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 262316010761 Walker A/P-loop; other site 262316010762 ATP binding site [chemical binding]; other site 262316010763 Q-loop/lid; other site 262316010764 ABC transporter signature motif; other site 262316010765 Walker B; other site 262316010766 D-loop; other site 262316010767 H-loop/switch region; other site 262316010768 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 262316010769 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 262316010770 intersubunit interface [polypeptide binding]; other site 262316010771 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 262316010772 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 262316010773 substrate binding pocket [chemical binding]; other site 262316010774 active site 262316010775 iron coordination sites [ion binding]; other site 262316010776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010777 S-adenosylmethionine binding site [chemical binding]; other site 262316010778 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 262316010779 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262316010780 Walker A/P-loop; other site 262316010781 ATP binding site [chemical binding]; other site 262316010782 Q-loop/lid; other site 262316010783 ABC transporter signature motif; other site 262316010784 Walker B; other site 262316010785 D-loop; other site 262316010786 H-loop/switch region; other site 262316010787 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 262316010788 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 262316010789 Walker A/P-loop; other site 262316010790 ATP binding site [chemical binding]; other site 262316010791 Q-loop/lid; other site 262316010792 ABC transporter signature motif; other site 262316010793 Walker B; other site 262316010794 D-loop; other site 262316010795 H-loop/switch region; other site 262316010796 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 262316010797 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 262316010798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262316010799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316010800 Walker A/P-loop; other site 262316010801 ATP binding site [chemical binding]; other site 262316010802 Q-loop/lid; other site 262316010803 ABC transporter signature motif; other site 262316010804 Walker B; other site 262316010805 D-loop; other site 262316010806 H-loop/switch region; other site 262316010807 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 262316010808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262316010809 Walker A/P-loop; other site 262316010810 ATP binding site [chemical binding]; other site 262316010811 Q-loop/lid; other site 262316010812 ABC transporter signature motif; other site 262316010813 Walker B; other site 262316010814 D-loop; other site 262316010815 H-loop/switch region; other site 262316010816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262316010817 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316010818 PPE family; Region: PPE; pfam00823 262316010819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010820 S-adenosylmethionine binding site [chemical binding]; other site 262316010821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316010822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262316010823 putative substrate translocation pore; other site 262316010824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316010825 putative substrate translocation pore; other site 262316010826 acyl-CoA synthetase; Validated; Region: PRK05850 262316010827 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316010828 acyl-activating enzyme (AAE) consensus motif; other site 262316010829 active site 262316010830 Phosphopantetheine attachment site; Region: PP-binding; cl09936 262316010831 Condensation domain; Region: Condensation; pfam00668 262316010832 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 262316010833 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 262316010834 acyl-activating enzyme (AAE) consensus motif; other site 262316010835 AMP binding site [chemical binding]; other site 262316010836 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316010837 Condensation domain; Region: Condensation; pfam00668 262316010838 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316010839 Methyltransferase domain; Region: Methyltransf_12; pfam08242 262316010840 Condensation domain; Region: Condensation; pfam00668 262316010841 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316010842 Nonribosomal peptide synthase; Region: NRPS; pfam08415 262316010843 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316010844 Condensation domain; Region: Condensation; pfam00668 262316010845 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 262316010846 Nonribosomal peptide synthase; Region: NRPS; pfam08415 262316010847 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 262316010848 acyl-activating enzyme (AAE) consensus motif; other site 262316010849 AMP binding site [chemical binding]; other site 262316010850 Methyltransferase domain; Region: Methyltransf_31; pfam13847 262316010851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010852 S-adenosylmethionine binding site [chemical binding]; other site 262316010853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316010854 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 262316010855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010856 NAD(P) binding site [chemical binding]; other site 262316010857 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 262316010858 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262316010859 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 262316010860 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 262316010861 putative homodimer interface [polypeptide binding]; other site 262316010862 putative homotetramer interface [polypeptide binding]; other site 262316010863 putative allosteric switch controlling residues; other site 262316010864 putative metal binding site [ion binding]; other site 262316010865 putative homodimer-homodimer interface [polypeptide binding]; other site 262316010866 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316010867 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 262316010868 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316010869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 262316010870 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316010871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010872 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316010873 NAD(P) binding site [chemical binding]; other site 262316010874 active site 262316010875 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316010876 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316010877 acyl-CoA synthetase; Validated; Region: PRK05850 262316010878 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 262316010879 acyl-activating enzyme (AAE) consensus motif; other site 262316010880 active site 262316010881 Transposase; Region: HTH_Tnp_1; cl17663 262316010882 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 262316010883 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316010884 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 262316010885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 262316010886 Helix-turn-helix domain; Region: HTH_18; pfam12833 262316010887 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262316010888 MULE transposase domain; Region: MULE; pfam10551 262316010889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316010890 S-adenosylmethionine binding site [chemical binding]; other site 262316010891 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 262316010892 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 262316010893 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 262316010894 homodimer interface [polypeptide binding]; other site 262316010895 active site 262316010896 TDP-binding site; other site 262316010897 acceptor substrate-binding pocket; other site 262316010898 peptide synthase; Provisional; Region: PRK12316 262316010899 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 262316010900 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 262316010901 active site 262316010902 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 262316010903 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 262316010904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316010905 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 262316010906 Enoylreductase; Region: PKS_ER; smart00829 262316010907 NAD(P) binding site [chemical binding]; other site 262316010908 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 262316010909 KR domain; Region: KR; pfam08659 262316010910 putative NADP binding site [chemical binding]; other site 262316010911 active site 262316010912 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 262316010913 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316010914 PPE family; Region: PPE; pfam00823 262316010915 Predicted permease; Region: DUF318; cl17795 262316010916 30S ribosomal protein S18; Provisional; Region: PRK13401 262316010917 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 262316010918 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 262316010919 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316010920 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262316010921 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 262316010922 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 262316010923 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 262316010924 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 262316010925 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 262316010926 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 262316010927 metal binding site 2 [ion binding]; metal-binding site 262316010928 putative DNA binding helix; other site 262316010929 metal binding site 1 [ion binding]; metal-binding site 262316010930 dimer interface [polypeptide binding]; other site 262316010931 structural Zn2+ binding site [ion binding]; other site 262316010932 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 262316010933 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 262316010934 ABC-ATPase subunit interface; other site 262316010935 dimer interface [polypeptide binding]; other site 262316010936 putative PBP binding regions; other site 262316010937 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 262316010938 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 262316010939 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 262316010940 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 262316010941 intersubunit interface [polypeptide binding]; other site 262316010942 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316010943 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316010944 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 262316010945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316010946 Walker A motif; other site 262316010947 ATP binding site [chemical binding]; other site 262316010948 Walker B motif; other site 262316010949 arginine finger; other site 262316010950 Protein of unknown function (DUF690); Region: DUF690; pfam05108 262316010951 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316010952 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316010953 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316010954 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316010955 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316010956 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316010957 PPE family; Region: PPE; pfam00823 262316010958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 262316010959 EspG family; Region: ESX-1_EspG; pfam14011 262316010960 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 262316010961 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316010962 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 262316010963 catalytic residues [active] 262316010964 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316010965 catalytic residues [active] 262316010966 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 262316010967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316010968 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 262316010969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262316010970 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 262316010971 Sulfatase; Region: Sulfatase; pfam00884 262316010972 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 262316010973 putative FMN binding site [chemical binding]; other site 262316010974 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 262316010975 active site 262316010976 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 262316010977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 262316010978 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 262316010979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316010980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316010981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316010982 nucleotide binding site [chemical binding]; other site 262316010983 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316010984 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 262316010985 Prostaglandin dehydrogenases; Region: PGDH; cd05288 262316010986 NAD(P) binding site [chemical binding]; other site 262316010987 substrate binding site [chemical binding]; other site 262316010988 dimer interface [polypeptide binding]; other site 262316010989 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 262316010990 active site 262316010991 catalytic residues [active] 262316010992 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 262316010993 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 262316010994 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 262316010995 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 262316010996 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262316010997 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262316010998 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316010999 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 262316011000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316011001 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316011002 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316011003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 262316011004 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316011005 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 262316011006 DNA binding site [nucleotide binding] 262316011007 active site 262316011008 Int/Topo IB signature motif; other site 262316011009 Protein of unknown function (DUF422); Region: DUF422; cl00991 262316011010 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316011011 Cytochrome P450; Region: p450; cl12078 262316011012 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 262316011013 trimer interface [polypeptide binding]; other site 262316011014 active site 262316011015 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 262316011016 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316011017 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 262316011018 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 262316011019 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 262316011020 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 262316011021 SnoaL-like domain; Region: SnoaL_2; pfam12680 262316011022 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 262316011023 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 262316011024 substrate binding site; other site 262316011025 tetramer interface; other site 262316011026 YibE/F-like protein; Region: YibE_F; pfam07907 262316011027 aminotransferase AlaT; Validated; Region: PRK09265 262316011028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316011029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316011030 homodimer interface [polypeptide binding]; other site 262316011031 catalytic residue [active] 262316011032 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 262316011033 4Fe-4S binding domain; Region: Fer4; pfam00037 262316011034 Cysteine-rich domain; Region: CCG; pfam02754 262316011035 Cysteine-rich domain; Region: CCG; pfam02754 262316011036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316011037 nucleotide binding site [chemical binding]; other site 262316011038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316011039 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 262316011040 putative substrate translocation pore; other site 262316011041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262316011042 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 262316011043 RES domain; Region: RES; smart00953 262316011044 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 262316011045 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 262316011046 nucleotide binding site [chemical binding]; other site 262316011047 NEF interaction site [polypeptide binding]; other site 262316011048 SBD interface [polypeptide binding]; other site 262316011049 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 262316011050 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 262316011051 dimer interface [polypeptide binding]; other site 262316011052 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 262316011053 chaperone protein DnaJ; Provisional; Region: PRK14279 262316011054 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 262316011055 HSP70 interaction site [polypeptide binding]; other site 262316011056 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 262316011057 Zn binding sites [ion binding]; other site 262316011058 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 262316011059 dimer interface [polypeptide binding]; other site 262316011060 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 262316011061 DNA binding residues [nucleotide binding] 262316011062 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 262316011063 putative dimer interface [polypeptide binding]; other site 262316011064 Predicted ATPase [General function prediction only]; Region: COG3899 262316011065 AAA ATPase domain; Region: AAA_16; pfam13191 262316011066 GAF domain; Region: GAF_3; pfam13492 262316011067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 262316011068 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316011069 cyclase homology domain; Region: CHD; cd07302 262316011070 nucleotidyl binding site; other site 262316011071 metal binding site [ion binding]; metal-binding site 262316011072 dimer interface [polypeptide binding]; other site 262316011073 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 262316011074 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316011075 substrate binding pocket [chemical binding]; other site 262316011076 chain length determination region; other site 262316011077 substrate-Mg2+ binding site; other site 262316011078 catalytic residues [active] 262316011079 aspartate-rich region 1; other site 262316011080 active site lid residues [active] 262316011081 aspartate-rich region 2; other site 262316011082 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 262316011083 Uncharacterized conserved protein [Function unknown]; Region: COG3349 262316011084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316011085 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 262316011086 active site 262316011087 catalytic residues [active] 262316011088 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 262316011089 heme-binding site [chemical binding]; other site 262316011090 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 262316011091 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 262316011092 FAD binding pocket [chemical binding]; other site 262316011093 FAD binding motif [chemical binding]; other site 262316011094 phosphate binding motif [ion binding]; other site 262316011095 beta-alpha-beta structure motif; other site 262316011096 NAD binding pocket [chemical binding]; other site 262316011097 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316011098 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 262316011099 Clp amino terminal domain; Region: Clp_N; pfam02861 262316011100 Clp amino terminal domain; Region: Clp_N; pfam02861 262316011101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316011102 Walker A motif; other site 262316011103 ATP binding site [chemical binding]; other site 262316011104 Walker B motif; other site 262316011105 arginine finger; other site 262316011106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316011107 Walker A motif; other site 262316011108 ATP binding site [chemical binding]; other site 262316011109 Walker B motif; other site 262316011110 arginine finger; other site 262316011111 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 262316011112 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 262316011113 Helix-turn-helix domain; Region: HTH_38; pfam13936 262316011114 DNA-binding interface [nucleotide binding]; DNA binding site 262316011115 Integrase core domain; Region: rve; pfam00665 262316011116 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 262316011117 classical (c) SDRs; Region: SDR_c; cd05233 262316011118 NAD(P) binding site [chemical binding]; other site 262316011119 active site 262316011120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262316011121 active site 262316011122 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262316011123 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262316011124 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 262316011125 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 262316011126 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 262316011127 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 262316011128 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 262316011129 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 262316011130 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 262316011131 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 262316011132 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 262316011133 Peptidase family M50; Region: Peptidase_M50; pfam02163 262316011134 active site 262316011135 putative substrate binding region [chemical binding]; other site 262316011136 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316011137 catalytic core [active] 262316011138 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 262316011139 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 262316011140 GDP-binding site [chemical binding]; other site 262316011141 ACT binding site; other site 262316011142 IMP binding site; other site 262316011143 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 262316011144 CoenzymeA binding site [chemical binding]; other site 262316011145 subunit interaction site [polypeptide binding]; other site 262316011146 PHB binding site; other site 262316011147 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 262316011148 ATP-grasp domain; Region: ATP-grasp_4; cl17255 262316011149 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 262316011150 active site residue [active] 262316011151 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 262316011152 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 262316011153 homodimer interface [polypeptide binding]; other site 262316011154 substrate-cofactor binding pocket; other site 262316011155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316011156 catalytic residue [active] 262316011157 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 262316011158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316011159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316011160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316011162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316011163 active site 262316011164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316011165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316011166 active site 262316011167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316011168 NAD(P) binding site [chemical binding]; other site 262316011169 active site 262316011170 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 262316011171 Leucine carboxyl methyltransferase; Region: LCM; cl01306 262316011172 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316011173 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262316011174 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 262316011175 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 262316011176 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316011177 phosphate acetyltransferase; Reviewed; Region: PRK05632 262316011178 DRTGG domain; Region: DRTGG; pfam07085 262316011179 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 262316011180 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 262316011181 propionate/acetate kinase; Provisional; Region: PRK12379 262316011182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 262316011183 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 262316011184 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316011185 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316011186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316011187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011188 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 262316011189 Catalytic domain of Protein Kinases; Region: PKc; cd00180 262316011190 active site 262316011191 ATP binding site [chemical binding]; other site 262316011192 substrate binding site [chemical binding]; other site 262316011193 activation loop (A-loop); other site 262316011194 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 262316011195 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 262316011196 substrate binding pocket [chemical binding]; other site 262316011197 membrane-bound complex binding site; other site 262316011198 hinge residues; other site 262316011199 NUDIX domain; Region: NUDIX; pfam00293 262316011200 nudix motif; other site 262316011201 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 262316011202 active site 262316011203 thiamine phosphate binding site [chemical binding]; other site 262316011204 pyrophosphate binding site [ion binding]; other site 262316011205 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 262316011206 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 262316011207 thiS-thiF/thiG interaction site; other site 262316011208 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 262316011209 ThiS interaction site; other site 262316011210 putative active site [active] 262316011211 tetramer interface [polypeptide binding]; other site 262316011212 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 262316011213 active site 262316011214 oxyanion hole [active] 262316011215 catalytic triad [active] 262316011216 Interferon-induced transmembrane protein; Region: CD225; pfam04505 262316011217 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 262316011218 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 262316011219 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 262316011220 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 262316011221 PA/protease or protease-like domain interface [polypeptide binding]; other site 262316011222 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 262316011223 active site 262316011224 metal binding site [ion binding]; metal-binding site 262316011225 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 262316011226 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 262316011227 PA/protease or protease-like domain interface [polypeptide binding]; other site 262316011228 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 262316011229 Peptidase family M28; Region: Peptidase_M28; pfam04389 262316011230 active site 262316011231 metal binding site [ion binding]; metal-binding site 262316011232 Predicted metalloprotease [General function prediction only]; Region: COG2321 262316011233 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 262316011234 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 262316011235 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316011236 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316011237 MarR family; Region: MarR; pfam01047 262316011238 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 262316011239 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 262316011240 dimer interface [polypeptide binding]; other site 262316011241 substrate binding site [chemical binding]; other site 262316011242 ATP binding site [chemical binding]; other site 262316011243 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 262316011244 ThiC-associated domain; Region: ThiC-associated; pfam13667 262316011245 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 262316011246 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 262316011247 putative catalytic site [active] 262316011248 putative phosphate binding site [ion binding]; other site 262316011249 active site 262316011250 metal binding site A [ion binding]; metal-binding site 262316011251 DNA binding site [nucleotide binding] 262316011252 putative AP binding site [nucleotide binding]; other site 262316011253 putative metal binding site B [ion binding]; other site 262316011254 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 262316011255 active site 262316011256 catalytic residues [active] 262316011257 metal binding site [ion binding]; metal-binding site 262316011258 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 262316011259 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 262316011260 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 262316011261 E-class dimer interface [polypeptide binding]; other site 262316011262 P-class dimer interface [polypeptide binding]; other site 262316011263 active site 262316011264 Cu2+ binding site [ion binding]; other site 262316011265 Zn2+ binding site [ion binding]; other site 262316011266 carboxylate-amine ligase; Provisional; Region: PRK13517 262316011267 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 262316011268 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 262316011269 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316011270 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316011271 enoyl-CoA hydratase; Provisional; Region: PRK08260 262316011272 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316011273 substrate binding site [chemical binding]; other site 262316011274 oxyanion hole (OAH) forming residues; other site 262316011275 trimer interface [polypeptide binding]; other site 262316011276 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 262316011277 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 262316011278 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 262316011279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316011280 Walker A motif; other site 262316011281 ATP binding site [chemical binding]; other site 262316011282 Walker B motif; other site 262316011283 arginine finger; other site 262316011284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262316011285 Walker A motif; other site 262316011286 ATP binding site [chemical binding]; other site 262316011287 Walker B motif; other site 262316011288 arginine finger; other site 262316011289 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 262316011290 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 262316011291 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 262316011292 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 262316011293 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 262316011294 dimer interface [polypeptide binding]; other site 262316011295 putative functional site; other site 262316011296 putative MPT binding site; other site 262316011297 short chain dehydrogenase; Provisional; Region: PRK06197 262316011298 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 262316011299 putative NAD(P) binding site [chemical binding]; other site 262316011300 active site 262316011301 Cupin domain; Region: Cupin_2; pfam07883 262316011302 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 262316011303 active site 262316011304 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 262316011305 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 262316011306 ring oligomerisation interface [polypeptide binding]; other site 262316011307 ATP/Mg binding site [chemical binding]; other site 262316011308 stacking interactions; other site 262316011309 hinge regions; other site 262316011310 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262316011311 putative active site [active] 262316011312 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 262316011313 PPE family; Region: PPE; pfam00823 262316011314 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316011315 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 262316011316 active site 262316011317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316011318 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 262316011319 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316011320 Protein of unknown function (DUF664); Region: DUF664; pfam04978 262316011321 DinB superfamily; Region: DinB_2; pfam12867 262316011322 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 262316011323 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 262316011324 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 262316011325 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262316011326 catalytic residues [active] 262316011327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316011328 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011329 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 262316011330 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 262316011331 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 262316011332 enoyl-CoA hydratase; Provisional; Region: PRK12478 262316011333 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316011334 substrate binding site [chemical binding]; other site 262316011335 oxyanion hole (OAH) forming residues; other site 262316011336 trimer interface [polypeptide binding]; other site 262316011337 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 262316011338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316011339 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 262316011340 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262316011341 NAD(P) binding site [chemical binding]; other site 262316011342 catalytic residues [active] 262316011343 Protein of unknown function (DUF779); Region: DUF779; cl01432 262316011344 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 262316011345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 262316011346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316011347 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262316011348 Uncharacterized conserved protein [Function unknown]; Region: COG2128 262316011349 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 262316011350 Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are...; Region: Calpain_III; cl00165 262316011351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 262316011352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316011353 non-specific DNA binding site [nucleotide binding]; other site 262316011354 salt bridge; other site 262316011355 sequence-specific DNA binding site [nucleotide binding]; other site 262316011356 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 262316011357 Domain of unknown function (DUF955); Region: DUF955; pfam06114 262316011358 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 262316011359 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 262316011360 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 262316011361 active site 262316011362 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 262316011363 active site 2 [active] 262316011364 isocitrate lyase; Provisional; Region: PRK15063 262316011365 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 262316011366 tetramer interface [polypeptide binding]; other site 262316011367 active site 262316011368 Mg2+/Mn2+ binding site [ion binding]; other site 262316011369 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 262316011370 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 262316011371 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 262316011372 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316011373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011374 S-adenosylmethionine binding site [chemical binding]; other site 262316011375 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316011376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011377 S-adenosylmethionine binding site [chemical binding]; other site 262316011378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316011379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011380 Predicted membrane protein [Function unknown]; Region: COG2733 262316011381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316011382 non-specific DNA binding site [nucleotide binding]; other site 262316011383 salt bridge; other site 262316011384 sequence-specific DNA binding site [nucleotide binding]; other site 262316011385 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 262316011386 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 262316011387 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 262316011388 catalytic residue [active] 262316011389 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 262316011390 Predicted amidohydrolase [General function prediction only]; Region: COG0388 262316011391 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 262316011392 putative active site [active] 262316011393 catalytic triad [active] 262316011394 putative dimer interface [polypeptide binding]; other site 262316011395 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 262316011396 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 262316011397 FAD binding domain; Region: FAD_binding_4; pfam01565 262316011398 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 262316011399 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 262316011400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 262316011401 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 262316011402 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 262316011403 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 262316011404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316011405 NAD(P) binding site [chemical binding]; other site 262316011406 active site 262316011407 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262316011408 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316011409 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 262316011410 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 262316011411 putative ADP-binding pocket [chemical binding]; other site 262316011412 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 262316011413 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316011414 catalytic core [active] 262316011415 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316011416 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 262316011417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 262316011418 dimer interface [polypeptide binding]; other site 262316011419 phosphorylation site [posttranslational modification] 262316011420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262316011421 ATP binding site [chemical binding]; other site 262316011422 Mg2+ binding site [ion binding]; other site 262316011423 G-X-G motif; other site 262316011424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 262316011425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316011426 active site 262316011427 phosphorylation site [posttranslational modification] 262316011428 intermolecular recognition site; other site 262316011429 dimerization interface [polypeptide binding]; other site 262316011430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 262316011431 DNA binding site [nucleotide binding] 262316011432 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 262316011433 nudix motif; other site 262316011434 exopolyphosphatase; Region: exo_poly_only; TIGR03706 262316011435 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 262316011436 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 262316011437 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 262316011438 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 262316011439 DNA interaction; other site 262316011440 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 262316011441 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 262316011442 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 262316011443 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 262316011444 DNA binding domain, excisionase family; Region: excise; TIGR01764 262316011445 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316011446 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 262316011447 putative NAD(P) binding site [chemical binding]; other site 262316011448 active site 262316011449 putative substrate binding site [chemical binding]; other site 262316011450 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 262316011451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 262316011452 putative acyl-acceptor binding pocket; other site 262316011453 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316011454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 262316011455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011456 S-adenosylmethionine binding site [chemical binding]; other site 262316011457 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316011458 active site 262316011459 catalytic site [active] 262316011460 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 262316011461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262316011462 motif II; other site 262316011463 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 262316011464 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 262316011465 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316011466 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 262316011467 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 262316011468 glutamyl-tRNA reductase; Region: hemA; TIGR01035 262316011469 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 262316011470 tRNA; other site 262316011471 putative tRNA binding site [nucleotide binding]; other site 262316011472 putative NADP binding site [chemical binding]; other site 262316011473 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 262316011474 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 262316011475 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 262316011476 domain interfaces; other site 262316011477 active site 262316011478 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 262316011479 active site 262316011480 homodimer interface [polypeptide binding]; other site 262316011481 SAM binding site [chemical binding]; other site 262316011482 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 262316011483 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 262316011484 active site 262316011485 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 262316011486 dimer interface [polypeptide binding]; other site 262316011487 active site 262316011488 Schiff base residues; other site 262316011489 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316011490 anti sigma factor interaction site; other site 262316011491 regulatory phosphorylation site [posttranslational modification]; other site 262316011492 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316011493 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 262316011494 active site 262316011495 catalytic triad [active] 262316011496 oxyanion hole [active] 262316011497 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316011498 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 262316011499 S-formylglutathione hydrolase; Region: PLN02442 262316011500 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 262316011501 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 262316011502 active site 262316011503 dimer interface [polypeptide binding]; other site 262316011504 non-prolyl cis peptide bond; other site 262316011505 insertion regions; other site 262316011506 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 262316011507 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 262316011508 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 262316011509 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 262316011510 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 262316011511 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 262316011512 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 262316011513 putative active site pocket [active] 262316011514 metal binding site [ion binding]; metal-binding site 262316011515 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 262316011516 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 262316011517 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 262316011518 inhibitor-cofactor binding pocket; inhibition site 262316011519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316011520 catalytic residue [active] 262316011521 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 262316011522 catalytic core [active] 262316011523 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 262316011524 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262316011525 catalytic residues [active] 262316011526 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 262316011527 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 262316011528 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 262316011529 ResB-like family; Region: ResB; pfam05140 262316011530 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 262316011531 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 262316011532 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 262316011533 P-loop; other site 262316011534 Magnesium ion binding site [ion binding]; other site 262316011535 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 262316011536 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 262316011537 dimer interface [polypeptide binding]; other site 262316011538 active site 262316011539 CoA binding pocket [chemical binding]; other site 262316011540 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 262316011541 UbiA prenyltransferase family; Region: UbiA; pfam01040 262316011542 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 262316011543 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316011544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316011545 NAD(P) binding site [chemical binding]; other site 262316011546 active site 262316011547 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 262316011548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 262316011549 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 262316011550 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 262316011551 Ligand binding site; other site 262316011552 Putative Catalytic site; other site 262316011553 DXD motif; other site 262316011554 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 262316011555 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 262316011556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316011557 acyl-activating enzyme (AAE) consensus motif; other site 262316011558 AMP binding site [chemical binding]; other site 262316011559 active site 262316011560 CoA binding site [chemical binding]; other site 262316011561 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 262316011562 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 262316011563 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 262316011564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 262316011565 active site 262316011566 short chain dehydrogenase; Provisional; Region: PRK05866 262316011567 classical (c) SDRs; Region: SDR_c; cd05233 262316011568 NAD(P) binding site [chemical binding]; other site 262316011569 active site 262316011570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316011571 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 262316011572 substrate binding site [chemical binding]; other site 262316011573 oxyanion hole (OAH) forming residues; other site 262316011574 trimer interface [polypeptide binding]; other site 262316011575 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316011576 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316011577 active site 262316011578 catalytic tetrad [active] 262316011579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011580 acyl-CoA synthetase; Validated; Region: PRK06188 262316011581 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316011582 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 262316011583 acyl-activating enzyme (AAE) consensus motif; other site 262316011584 acyl-activating enzyme (AAE) consensus motif; other site 262316011585 putative AMP binding site [chemical binding]; other site 262316011586 putative active site [active] 262316011587 putative CoA binding site [chemical binding]; other site 262316011588 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 262316011589 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 262316011590 active site 262316011591 O-succinylbenzoate synthase; Provisional; Region: PRK02901 262316011592 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 262316011593 active site 262316011594 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 262316011595 TAP-like protein; Region: Abhydrolase_4; pfam08386 262316011596 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 262316011597 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 262316011598 dimer interface [polypeptide binding]; other site 262316011599 tetramer interface [polypeptide binding]; other site 262316011600 PYR/PP interface [polypeptide binding]; other site 262316011601 TPP binding site [chemical binding]; other site 262316011602 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 262316011603 TPP-binding site; other site 262316011604 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 262316011605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 262316011606 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 262316011607 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 262316011608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011609 S-adenosylmethionine binding site [chemical binding]; other site 262316011610 Protein of unknown function (DUF732); Region: DUF732; pfam05305 262316011611 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 262316011612 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316011613 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 262316011614 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 262316011615 substrate binding pocket [chemical binding]; other site 262316011616 chain length determination region; other site 262316011617 substrate-Mg2+ binding site; other site 262316011618 catalytic residues [active] 262316011619 aspartate-rich region 1; other site 262316011620 active site lid residues [active] 262316011621 aspartate-rich region 2; other site 262316011622 heat shock protein HtpX; Provisional; Region: PRK03072 262316011623 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 262316011624 Sulfate transporter family; Region: Sulfate_transp; pfam00916 262316011625 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 262316011626 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 262316011627 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 262316011628 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 262316011629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316011630 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 262316011631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 262316011632 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 262316011633 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316011634 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316011635 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 262316011636 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 262316011637 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316011638 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316011639 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 262316011640 Cytochrome P450; Region: p450; cl12078 262316011641 NYN domain; Region: NYN; pfam01936 262316011642 Uncharacterized conserved protein [Function unknown]; Region: COG1432 262316011643 putative metal binding site [ion binding]; other site 262316011644 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 262316011645 Predicted membrane protein [Function unknown]; Region: COG1289 262316011646 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 262316011647 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 262316011648 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 262316011649 dimer interface [polypeptide binding]; other site 262316011650 active site 262316011651 galactokinase; Provisional; Region: PRK00555 262316011652 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 262316011653 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 262316011654 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 262316011655 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 262316011656 Uncharacterized conserved protein [Function unknown]; Region: COG1656 262316011657 Protein of unknown function DUF82; Region: DUF82; pfam01927 262316011658 PAS fold; Region: PAS_3; pfam08447 262316011659 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 262316011660 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 262316011661 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 262316011662 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 262316011663 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 262316011664 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316011665 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316011666 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316011667 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316011668 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 262316011669 Transcriptional regulators [Transcription]; Region: FadR; COG2186 262316011670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 262316011671 DNA-binding site [nucleotide binding]; DNA binding site 262316011672 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316011673 Permease; Region: Permease; pfam02405 262316011674 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 262316011675 Permease; Region: Permease; pfam02405 262316011676 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316011677 mce related protein; Region: MCE; pfam02470 262316011678 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 262316011679 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 262316011680 mce related protein; Region: MCE; pfam02470 262316011681 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316011682 mce related protein; Region: MCE; pfam02470 262316011683 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316011684 mce related protein; Region: MCE; pfam02470 262316011685 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316011686 mce related protein; Region: MCE; pfam02470 262316011687 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 262316011688 mce related protein; Region: MCE; pfam02470 262316011689 Uncharacterized conserved protein [Function unknown]; Region: COG0398 262316011690 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 262316011691 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 262316011692 AAA domain; Region: AAA_30; pfam13604 262316011693 Family description; Region: UvrD_C_2; pfam13538 262316011694 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 262316011695 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 262316011696 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 262316011697 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 262316011698 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 262316011699 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316011700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011701 S-adenosylmethionine binding site [chemical binding]; other site 262316011702 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 262316011703 FMN binding site [chemical binding]; other site 262316011704 dimer interface [polypeptide binding]; other site 262316011705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011706 S-adenosylmethionine binding site [chemical binding]; other site 262316011707 cyanate hydratase; Validated; Region: PRK02866 262316011708 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 262316011709 oligomer interface [polypeptide binding]; other site 262316011710 active site 262316011711 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 262316011712 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 262316011713 active site 262316011714 nucleophile elbow; other site 262316011715 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 262316011716 molybdopterin cofactor binding site; other site 262316011717 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 262316011718 molybdopterin cofactor binding site; other site 262316011719 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316011720 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316011721 substrate binding site [chemical binding]; other site 262316011722 oxyanion hole (OAH) forming residues; other site 262316011723 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 262316011724 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 262316011725 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 262316011726 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316011727 active site 262316011728 catalytic site [active] 262316011729 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 262316011730 active site 262316011731 catalytic site [active] 262316011732 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 262316011733 active site 262316011734 catalytic site [active] 262316011735 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 262316011736 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 262316011737 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 262316011738 putative homodimer interface [polypeptide binding]; other site 262316011739 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 262316011740 heterodimer interface [polypeptide binding]; other site 262316011741 homodimer interface [polypeptide binding]; other site 262316011742 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 262316011743 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 262316011744 23S rRNA interface [nucleotide binding]; other site 262316011745 L7/L12 interface [polypeptide binding]; other site 262316011746 putative thiostrepton binding site; other site 262316011747 L25 interface [polypeptide binding]; other site 262316011748 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 262316011749 mRNA/rRNA interface [nucleotide binding]; other site 262316011750 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 262316011751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316011752 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 262316011753 DNA binding residues [nucleotide binding] 262316011754 YCII-related domain; Region: YCII; cl00999 262316011755 YCII-related domain; Region: YCII; cl00999 262316011756 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316011757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011758 S-adenosylmethionine binding site [chemical binding]; other site 262316011759 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 262316011760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262316011761 S-adenosylmethionine binding site [chemical binding]; other site 262316011762 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 262316011763 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 262316011764 TAP-like protein; Region: Abhydrolase_4; pfam08386 262316011765 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 262316011766 ABC1 family; Region: ABC1; pfam03109 262316011767 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 262316011768 active site 262316011769 ATP binding site [chemical binding]; other site 262316011770 Protein of unknown function (DUF664); Region: DUF664; pfam04978 262316011771 DinB superfamily; Region: DinB_2; pfam12867 262316011772 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 262316011773 active site 262316011774 catalytic site [active] 262316011775 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 262316011776 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 262316011777 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 262316011778 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262316011779 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316011780 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 262316011781 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 262316011782 23S rRNA interface [nucleotide binding]; other site 262316011783 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 262316011784 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 262316011785 core dimer interface [polypeptide binding]; other site 262316011786 peripheral dimer interface [polypeptide binding]; other site 262316011787 L10 interface [polypeptide binding]; other site 262316011788 L11 interface [polypeptide binding]; other site 262316011789 putative EF-Tu interaction site [polypeptide binding]; other site 262316011790 putative EF-G interaction site [polypeptide binding]; other site 262316011791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316011792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011793 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 262316011794 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 262316011795 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 262316011796 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 262316011797 Walker A/P-loop; other site 262316011798 ATP binding site [chemical binding]; other site 262316011799 Q-loop/lid; other site 262316011800 ABC transporter signature motif; other site 262316011801 Walker B; other site 262316011802 D-loop; other site 262316011803 H-loop/switch region; other site 262316011804 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 262316011805 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 262316011806 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 262316011807 RPB10 interaction site [polypeptide binding]; other site 262316011808 RPB1 interaction site [polypeptide binding]; other site 262316011809 RPB11 interaction site [polypeptide binding]; other site 262316011810 RPB3 interaction site [polypeptide binding]; other site 262316011811 RPB12 interaction site [polypeptide binding]; other site 262316011812 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 262316011813 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 262316011814 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 262316011815 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 262316011816 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 262316011817 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 262316011818 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 262316011819 G-loop; other site 262316011820 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 262316011821 DNA binding site [nucleotide binding] 262316011822 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 262316011823 endonuclease IV; Provisional; Region: PRK01060 262316011824 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 262316011825 AP (apurinic/apyrimidinic) site pocket; other site 262316011826 DNA interaction; other site 262316011827 Metal-binding active site; metal-binding site 262316011828 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 262316011829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316011830 active site 262316011831 enoyl-CoA hydratase; Provisional; Region: PRK12478 262316011832 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316011833 substrate binding site [chemical binding]; other site 262316011834 oxyanion hole (OAH) forming residues; other site 262316011835 trimer interface [polypeptide binding]; other site 262316011836 PaaX-like protein; Region: PaaX; pfam07848 262316011837 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 262316011838 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 262316011839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 262316011840 substrate binding site [chemical binding]; other site 262316011841 oxyanion hole (OAH) forming residues; other site 262316011842 trimer interface [polypeptide binding]; other site 262316011843 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316011844 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 262316011845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316011846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011847 WHG domain; Region: WHG; pfam13305 262316011848 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 262316011849 S17 interaction site [polypeptide binding]; other site 262316011850 S8 interaction site; other site 262316011851 16S rRNA interaction site [nucleotide binding]; other site 262316011852 streptomycin interaction site [chemical binding]; other site 262316011853 23S rRNA interaction site [nucleotide binding]; other site 262316011854 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 262316011855 30S ribosomal protein S7; Validated; Region: PRK05302 262316011856 elongation factor G; Reviewed; Region: PRK00007 262316011857 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 262316011858 G1 box; other site 262316011859 putative GEF interaction site [polypeptide binding]; other site 262316011860 GTP/Mg2+ binding site [chemical binding]; other site 262316011861 Switch I region; other site 262316011862 G2 box; other site 262316011863 G3 box; other site 262316011864 Switch II region; other site 262316011865 G4 box; other site 262316011866 G5 box; other site 262316011867 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 262316011868 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 262316011869 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 262316011870 elongation factor Tu; Reviewed; Region: PRK00049 262316011871 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 262316011872 G1 box; other site 262316011873 GEF interaction site [polypeptide binding]; other site 262316011874 GTP/Mg2+ binding site [chemical binding]; other site 262316011875 Switch I region; other site 262316011876 G2 box; other site 262316011877 G3 box; other site 262316011878 Switch II region; other site 262316011879 G4 box; other site 262316011880 G5 box; other site 262316011881 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 262316011882 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 262316011883 Antibiotic Binding Site [chemical binding]; other site 262316011884 PE family; Region: PE; pfam00934 262316011885 Short C-terminal domain; Region: SHOCT; pfam09851 262316011886 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316011887 classical (c) SDRs; Region: SDR_c; cd05233 262316011888 NAD(P) binding site [chemical binding]; other site 262316011889 active site 262316011890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 262316011891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316011892 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 262316011893 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 262316011894 active site 262316011895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 262316011896 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 262316011897 active site 262316011898 catalytic tetrad [active] 262316011899 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 262316011900 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 262316011901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316011902 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 262316011903 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 262316011904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 262316011905 FeS/SAM binding site; other site 262316011906 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 262316011907 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 262316011908 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262316011909 phosphate binding site [ion binding]; other site 262316011910 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 262316011911 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 262316011912 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 262316011913 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 262316011914 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 262316011915 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 262316011916 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 262316011917 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 262316011918 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 262316011919 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 262316011920 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 262316011921 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 262316011922 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 262316011923 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 262316011924 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 262316011925 putative translocon binding site; other site 262316011926 protein-rRNA interface [nucleotide binding]; other site 262316011927 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 262316011928 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 262316011929 G-X-X-G motif; other site 262316011930 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 262316011931 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 262316011932 23S rRNA interface [nucleotide binding]; other site 262316011933 5S rRNA interface [nucleotide binding]; other site 262316011934 putative antibiotic binding site [chemical binding]; other site 262316011935 L25 interface [polypeptide binding]; other site 262316011936 L27 interface [polypeptide binding]; other site 262316011937 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 262316011938 putative translocon interaction site; other site 262316011939 signal recognition particle (SRP54) interaction site; other site 262316011940 L23 interface [polypeptide binding]; other site 262316011941 trigger factor interaction site; other site 262316011942 23S rRNA interface [nucleotide binding]; other site 262316011943 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 262316011944 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 262316011945 Sulfatase; Region: Sulfatase; pfam00884 262316011946 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 262316011947 PBP superfamily domain; Region: PBP_like_2; cl17296 262316011948 Uncharacterized conserved protein [Function unknown]; Region: COG1262 262316011949 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 262316011950 Domain of unknown function (DUF222); Region: DUF222; pfam02720 262316011951 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 262316011952 active site 262316011953 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 262316011954 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 262316011955 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 262316011956 RNA binding site [nucleotide binding]; other site 262316011957 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 262316011958 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 262316011959 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 262316011960 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 262316011961 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 262316011962 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 262316011963 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262316011964 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262316011965 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 262316011966 5S rRNA interface [nucleotide binding]; other site 262316011967 L27 interface [polypeptide binding]; other site 262316011968 23S rRNA interface [nucleotide binding]; other site 262316011969 L5 interface [polypeptide binding]; other site 262316011970 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 262316011971 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 262316011972 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 262316011973 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 262316011974 23S rRNA binding site [nucleotide binding]; other site 262316011975 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 262316011976 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316011977 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 262316011978 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 262316011979 tandem repeat interface [polypeptide binding]; other site 262316011980 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 262316011981 oligomer interface [polypeptide binding]; other site 262316011982 active site residues [active] 262316011983 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 262316011984 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 262316011985 tandem repeat interface [polypeptide binding]; other site 262316011986 oligomer interface [polypeptide binding]; other site 262316011987 active site residues [active] 262316011988 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316011989 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316011990 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316011991 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316011992 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316011993 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316011994 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 262316011995 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 262316011996 NAD(P) binding site [chemical binding]; other site 262316011997 L-fuculose-phosphate aldolase; Validated; Region: PRK05874 262316011998 intersubunit interface [polypeptide binding]; other site 262316011999 active site 262316012000 Zn2+ binding site [ion binding]; other site 262316012001 glyoxylate reductase; Reviewed; Region: PRK13243 262316012002 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 262316012003 NAD binding site [chemical binding]; other site 262316012004 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 262316012005 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262316012006 nucleotide binding site [chemical binding]; other site 262316012007 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 262316012008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316012009 Coenzyme A binding pocket [chemical binding]; other site 262316012010 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 262316012011 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 262316012012 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 262316012013 SecY translocase; Region: SecY; pfam00344 262316012014 adenylate kinase; Reviewed; Region: adk; PRK00279 262316012015 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 262316012016 AMP-binding site [chemical binding]; other site 262316012017 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 262316012018 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 262316012019 active site 262316012020 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 262316012021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316012022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316012023 DNA binding residues [nucleotide binding] 262316012024 Putative zinc-finger; Region: zf-HC2; pfam13490 262316012025 hypothetical protein; Provisional; Region: PRK07236 262316012026 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262316012027 Methyltransferase domain; Region: Methyltransf_11; pfam08241 262316012028 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 262316012029 FtsX-like permease family; Region: FtsX; pfam02687 262316012030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262316012031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 262316012032 Walker A/P-loop; other site 262316012033 ATP binding site [chemical binding]; other site 262316012034 Q-loop/lid; other site 262316012035 ABC transporter signature motif; other site 262316012036 Walker B; other site 262316012037 D-loop; other site 262316012038 H-loop/switch region; other site 262316012039 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 262316012040 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262316012041 PYR/PP interface [polypeptide binding]; other site 262316012042 dimer interface [polypeptide binding]; other site 262316012043 TPP binding site [chemical binding]; other site 262316012044 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 262316012045 TPP-binding site [chemical binding]; other site 262316012046 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 262316012047 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 262316012048 active site 262316012049 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 262316012050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 262316012051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316012052 homodimer interface [polypeptide binding]; other site 262316012053 catalytic residue [active] 262316012054 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 262316012055 MarR family; Region: MarR; pfam01047 262316012056 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 262316012057 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 262316012058 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316012059 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 262316012060 substrate binding pocket [chemical binding]; other site 262316012061 FAD binding site [chemical binding]; other site 262316012062 catalytic base [active] 262316012063 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 262316012064 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 262316012065 tetrameric interface [polypeptide binding]; other site 262316012066 NAD binding site [chemical binding]; other site 262316012067 catalytic residues [active] 262316012068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 262316012069 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 262316012070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316012071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316012072 DNA binding residues [nucleotide binding] 262316012073 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 262316012074 iron-sulfur cluster [ion binding]; other site 262316012075 [2Fe-2S] cluster binding site [ion binding]; other site 262316012076 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 262316012077 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 262316012078 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262316012079 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 262316012080 active site 262316012081 metal binding site [ion binding]; metal-binding site 262316012082 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316012083 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316012084 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 262316012085 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 262316012086 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 262316012087 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 262316012088 NAD binding site [chemical binding]; other site 262316012089 substrate binding site [chemical binding]; other site 262316012090 homodimer interface [polypeptide binding]; other site 262316012091 active site 262316012092 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 262316012093 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 262316012094 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 262316012095 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 262316012096 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 262316012097 rRNA binding site [nucleotide binding]; other site 262316012098 predicted 30S ribosome binding site; other site 262316012099 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 262316012100 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 262316012101 30S ribosomal protein S13; Region: bact_S13; TIGR03631 262316012102 30S ribosomal protein S11; Validated; Region: PRK05309 262316012103 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 262316012104 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 262316012105 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262316012106 RNA binding surface [nucleotide binding]; other site 262316012107 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 262316012108 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 262316012109 alphaNTD homodimer interface [polypeptide binding]; other site 262316012110 alphaNTD - beta interaction site [polypeptide binding]; other site 262316012111 alphaNTD - beta' interaction site [polypeptide binding]; other site 262316012112 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 262316012113 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 262316012114 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 262316012115 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 262316012116 active site 262316012117 dimerization interface 3.5A [polypeptide binding]; other site 262316012118 Cutinase; Region: Cutinase; pfam01083 262316012119 Cutinase; Region: Cutinase; pfam01083 262316012120 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 262316012121 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 262316012122 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262316012123 active site 262316012124 catalytic residues [active] 262316012125 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 262316012126 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316012127 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316012128 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316012129 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316012130 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316012131 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 262316012132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 262316012133 Proteins of 100 residues with WXG; Region: WXG100; cl02005 262316012134 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 262316012135 23S rRNA interface [nucleotide binding]; other site 262316012136 L3 interface [polypeptide binding]; other site 262316012137 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 262316012138 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 262316012139 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 262316012140 active site 262316012141 substrate binding site [chemical binding]; other site 262316012142 metal binding site [ion binding]; metal-binding site 262316012143 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 262316012144 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 262316012145 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 262316012146 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 262316012147 glutaminase active site [active] 262316012148 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 262316012149 dimer interface [polypeptide binding]; other site 262316012150 active site 262316012151 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 262316012152 dimer interface [polypeptide binding]; other site 262316012153 active site 262316012154 Uncharacterized conserved protein [Function unknown]; Region: COG0062 262316012155 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 262316012156 putative substrate binding site [chemical binding]; other site 262316012157 putative ATP binding site [chemical binding]; other site 262316012158 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 262316012159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 262316012160 catalytic residue [active] 262316012161 alanine racemase; Reviewed; Region: alr; PRK00053 262316012162 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 262316012163 active site 262316012164 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 262316012165 dimer interface [polypeptide binding]; other site 262316012166 substrate binding site [chemical binding]; other site 262316012167 catalytic residues [active] 262316012168 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262316012169 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 262316012170 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 262316012171 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 262316012172 Glycoprotease family; Region: Peptidase_M22; pfam00814 262316012173 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 262316012174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 262316012175 Coenzyme A binding pocket [chemical binding]; other site 262316012176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 262316012177 UGMP family protein; Validated; Region: PRK09604 262316012178 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 262316012179 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 262316012180 oligomerisation interface [polypeptide binding]; other site 262316012181 mobile loop; other site 262316012182 roof hairpin; other site 262316012183 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 262316012184 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 262316012185 ring oligomerisation interface [polypeptide binding]; other site 262316012186 ATP/Mg binding site [chemical binding]; other site 262316012187 stacking interactions; other site 262316012188 hinge regions; other site 262316012189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 262316012190 dimerization interface [polypeptide binding]; other site 262316012191 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 262316012192 cyclase homology domain; Region: CHD; cd07302 262316012193 nucleotidyl binding site; other site 262316012194 metal binding site [ion binding]; metal-binding site 262316012195 dimer interface [polypeptide binding]; other site 262316012196 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 262316012197 non-specific DNA binding site [nucleotide binding]; other site 262316012198 salt bridge; other site 262316012199 sequence-specific DNA binding site [nucleotide binding]; other site 262316012200 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 262316012201 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 262316012202 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 262316012203 hypothetical protein; Provisional; Region: PRK06185 262316012204 hypothetical protein; Provisional; Region: PRK07236 262316012205 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 262316012206 E-class dimer interface [polypeptide binding]; other site 262316012207 P-class dimer interface [polypeptide binding]; other site 262316012208 active site 262316012209 Cu2+ binding site [ion binding]; other site 262316012210 Zn2+ binding site [ion binding]; other site 262316012211 Transcription factor WhiB; Region: Whib; pfam02467 262316012212 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 262316012213 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316012214 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 262316012215 DNA binding residues [nucleotide binding] 262316012216 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 262316012217 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262316012218 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 262316012219 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262316012220 phosphate binding site [ion binding]; other site 262316012221 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 262316012222 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262316012223 phosphate binding site [ion binding]; other site 262316012224 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 262316012225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 262316012226 Transposase; Region: DEDD_Tnp_IS110; pfam01548 262316012227 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 262316012228 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 262316012229 classical (c) SDRs; Region: SDR_c; cd05233 262316012230 NAD(P) binding site [chemical binding]; other site 262316012231 active site 262316012232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 262316012233 metal-binding site [ion binding] 262316012234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 262316012235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 262316012236 metal-binding site [ion binding] 262316012237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262316012238 Predicted esterase [General function prediction only]; Region: COG0627 262316012239 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 262316012240 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 262316012241 NodB motif; other site 262316012242 active site 262316012243 catalytic site [active] 262316012244 metal binding site [ion binding]; metal-binding site 262316012245 MarR family; Region: MarR_2; pfam12802 262316012246 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 262316012247 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 262316012248 Secretory lipase; Region: LIP; pfam03583 262316012249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 262316012250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316012251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316012252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262316012253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 262316012254 classical (c) SDRs; Region: SDR_c; cd05233 262316012255 NAD(P) binding site [chemical binding]; other site 262316012256 active site 262316012257 acyl-CoA synthetase; Provisional; Region: PRK13388 262316012258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 262316012259 acyl-activating enzyme (AAE) consensus motif; other site 262316012260 AMP binding site [chemical binding]; other site 262316012261 active site 262316012262 CoA binding site [chemical binding]; other site 262316012263 Predicted transcriptional regulators [Transcription]; Region: COG1695 262316012264 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 262316012265 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316012266 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316012267 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 262316012268 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316012269 active site 262316012270 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316012271 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316012272 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 262316012273 CoA-transferase family III; Region: CoA_transf_3; pfam02515 262316012274 Amidohydrolase; Region: Amidohydro_2; pfam04909 262316012275 Transcriptional regulators [Transcription]; Region: PurR; COG1609 262316012276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 262316012277 DNA binding site [nucleotide binding] 262316012278 domain linker motif; other site 262316012279 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 262316012280 dimerization interface [polypeptide binding]; other site 262316012281 ligand binding site [chemical binding]; other site 262316012282 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 262316012283 DUF35 OB-fold domain; Region: DUF35; pfam01796 262316012284 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 262316012285 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 262316012286 active site 262316012287 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316012288 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 262316012289 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316012290 active site 262316012291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 262316012292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 262316012293 active site 262316012294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316012295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316012296 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 262316012297 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 262316012298 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 262316012299 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 262316012300 putative active site [active] 262316012301 catalytic residue [active] 262316012302 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 262316012303 anti sigma factor interaction site; other site 262316012304 regulatory phosphorylation site [posttranslational modification]; other site 262316012305 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 262316012306 Phosphotransferase enzyme family; Region: APH; pfam01636 262316012307 putative active site [active] 262316012308 ATP binding site [chemical binding]; other site 262316012309 putative substrate binding site [chemical binding]; other site 262316012310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 262316012311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 262316012312 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 262316012313 Ecdysteroid kinase; Region: EcKinase; cl17738 262316012314 Phosphotransferase enzyme family; Region: APH; pfam01636 262316012315 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 262316012316 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 262316012317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316012318 active site 262316012319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262316012320 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 262316012321 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 262316012322 [2Fe-2S] cluster binding site [ion binding]; other site 262316012323 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 262316012324 putative alpha subunit interface [polypeptide binding]; other site 262316012325 putative active site [active] 262316012326 putative substrate binding site [chemical binding]; other site 262316012327 Fe binding site [ion binding]; other site 262316012328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 262316012329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 262316012330 active site 262316012331 phosphorylation site [posttranslational modification] 262316012332 intermolecular recognition site; other site 262316012333 dimerization interface [polypeptide binding]; other site 262316012334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 262316012335 DNA binding residues [nucleotide binding] 262316012336 dimerization interface [polypeptide binding]; other site 262316012337 Histidine kinase; Region: HisKA_3; pfam07730 262316012338 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 262316012339 Transport protein; Region: actII; TIGR00833 262316012340 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 262316012341 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316012342 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 262316012343 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316012344 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 262316012345 Protein of unknown function (DUF690); Region: DUF690; cl04939 262316012346 Protein of unknown function (DUF690); Region: DUF690; cl04939 262316012347 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 262316012348 catalytic residue [active] 262316012349 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 262316012350 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 262316012351 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 262316012352 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 262316012353 active site 262316012354 NTP binding site [chemical binding]; other site 262316012355 metal binding triad [ion binding]; metal-binding site 262316012356 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 262316012357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262316012358 Zn2+ binding site [ion binding]; other site 262316012359 Mg2+ binding site [ion binding]; other site 262316012360 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 262316012361 Flagellar FliJ protein; Region: FliJ; pfam02050 262316012362 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 262316012363 active site 262316012364 Ap6A binding site [chemical binding]; other site 262316012365 nudix motif; other site 262316012366 metal binding site [ion binding]; metal-binding site 262316012367 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 262316012368 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 262316012369 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 262316012370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262316012371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262316012372 DNA binding residues [nucleotide binding] 262316012373 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 262316012374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262316012375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262316012376 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262316012377 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 262316012378 catalytic residues [active] 262316012379 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 262316012380 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 262316012381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 262316012382 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 262316012383 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 262316012384 active site 262316012385 metal binding site [ion binding]; metal-binding site 262316012386 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 262316012387 ParB-like nuclease domain; Region: ParBc; pfam02195 262316012388 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 262316012389 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 262316012390 P-loop; other site 262316012391 Magnesium ion binding site [ion binding]; other site 262316012392 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 262316012393 Magnesium ion binding site [ion binding]; other site 262316012394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 262316012395 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 262316012396 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 262316012397 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 262316012398 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 262316012399 G-X-X-G motif; other site 262316012400 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 262316012401 RxxxH motif; other site 262316012402 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 262316012403 hypothetical protein; Validated; Region: PRK00041 262316012404 ribonuclease P; Reviewed; Region: rnpA; PRK00588 262316012405 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399