-- dump date 20140619_150928 -- class Genbank::misc_feature -- table misc_feature_note -- id note 36809000001 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 36809000002 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 36809000003 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 36809000004 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 36809000005 catalytic residues [active] 36809000006 catalytic nucleophile [active] 36809000007 Presynaptic Site I dimer interface [polypeptide binding]; other site 36809000008 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 36809000009 Synaptic Flat tetramer interface [polypeptide binding]; other site 36809000010 Synaptic Site I dimer interface [polypeptide binding]; other site 36809000011 DNA binding site [nucleotide binding] 36809000012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809000013 dimerization interface [polypeptide binding]; other site 36809000014 putative DNA binding site [nucleotide binding]; other site 36809000015 putative Zn2+ binding site [ion binding]; other site 36809000016 mercuric reductase; Region: MerA; TIGR02053 36809000017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809000018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809000019 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809000020 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 36809000021 alkylmercury lyase; Provisional; Region: PRK13239 36809000022 Alkylmercury lyase; Region: MerB; pfam03243 36809000023 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 36809000024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809000025 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809000026 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 36809000027 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 36809000028 catalytic residues [active] 36809000029 catalytic nucleophile [active] 36809000030 Presynaptic Site I dimer interface [polypeptide binding]; other site 36809000031 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 36809000032 Synaptic Flat tetramer interface [polypeptide binding]; other site 36809000033 Synaptic Site I dimer interface [polypeptide binding]; other site 36809000034 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 36809000035 DNA-binding interface [nucleotide binding]; DNA binding site 36809000036 TrwC relaxase; Region: TrwC; pfam08751 36809000037 AAA domain; Region: AAA_30; pfam13604 36809000038 AAA domain; Region: AAA_11; pfam13086 36809000039 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 36809000040 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 36809000041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 36809000042 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809000043 P-loop; other site 36809000044 Magnesium ion binding site [ion binding]; other site 36809000045 Abi-like protein; Region: Abi_2; pfam07751 36809000046 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 36809000047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809000048 Walker A motif; other site 36809000049 ATP binding site [chemical binding]; other site 36809000050 Walker B motif; other site 36809000051 arginine finger; other site 36809000052 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 36809000053 DnaA box-binding interface [nucleotide binding]; other site 36809000054 DNA polymerase III subunit beta; Validated; Region: PRK07761 36809000055 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 36809000056 putative DNA binding surface [nucleotide binding]; other site 36809000057 dimer interface [polypeptide binding]; other site 36809000058 beta-clamp/clamp loader binding surface; other site 36809000059 beta-clamp/translesion DNA polymerase binding surface; other site 36809000060 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 36809000061 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 36809000062 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 36809000063 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 36809000064 recombination protein F; Reviewed; Region: recF; PRK00064 36809000065 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 36809000066 Walker A/P-loop; other site 36809000067 ATP binding site [chemical binding]; other site 36809000068 Q-loop/lid; other site 36809000069 ABC transporter signature motif; other site 36809000070 Walker B; other site 36809000071 D-loop; other site 36809000072 H-loop/switch region; other site 36809000073 hypothetical protein; Provisional; Region: PRK03195 36809000074 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 36809000075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809000076 ATP binding site [chemical binding]; other site 36809000077 Mg2+ binding site [ion binding]; other site 36809000078 G-X-G motif; other site 36809000079 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 36809000080 anchoring element; other site 36809000081 dimer interface [polypeptide binding]; other site 36809000082 ATP binding site [chemical binding]; other site 36809000083 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 36809000084 active site 36809000085 metal binding site [ion binding]; metal-binding site 36809000086 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 36809000087 Proteins of 100 residues with WXG; Region: WXG100; cl02005 36809000088 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809000089 N-acetyltransferase; Region: Acetyltransf_2; cl00949 36809000090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 36809000091 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 36809000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809000093 S-adenosylmethionine binding site [chemical binding]; other site 36809000094 DNA gyrase subunit A; Validated; Region: PRK05560 36809000095 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 36809000096 CAP-like domain; other site 36809000097 active site 36809000098 primary dimer interface [polypeptide binding]; other site 36809000099 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 36809000100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 36809000101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 36809000102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 36809000103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 36809000104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 36809000105 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 36809000106 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 36809000107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809000108 putative substrate translocation pore; other site 36809000109 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 36809000110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809000111 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 36809000112 dimerization interface [polypeptide binding]; other site 36809000113 substrate binding pocket [chemical binding]; other site 36809000114 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 36809000115 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 36809000116 active site 36809000117 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 36809000118 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 36809000119 Bacterial PH domain; Region: bPH_6; pfam10756 36809000120 putative septation inhibitor protein; Reviewed; Region: PRK00159 36809000121 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 36809000122 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 36809000123 Glutamine amidotransferase class-I; Region: GATase; pfam00117 36809000124 glutamine binding [chemical binding]; other site 36809000125 catalytic triad [active] 36809000126 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 36809000127 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 36809000128 active site 36809000129 ATP binding site [chemical binding]; other site 36809000130 substrate binding site [chemical binding]; other site 36809000131 activation loop (A-loop); other site 36809000132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 36809000133 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 36809000134 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 36809000135 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 36809000136 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 36809000137 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 36809000138 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 36809000139 active site 36809000140 ATP binding site [chemical binding]; other site 36809000141 substrate binding site [chemical binding]; other site 36809000142 activation loop (A-loop); other site 36809000143 Vinculin family; Region: Vinculin; pfam01044 36809000144 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 36809000145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 36809000146 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 36809000147 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 36809000148 active site 36809000149 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 36809000150 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 36809000151 phosphopeptide binding site; other site 36809000152 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 36809000153 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 36809000154 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 36809000155 phosphopeptide binding site; other site 36809000156 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 36809000157 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 36809000158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000160 PE family; Region: PE; pfam00934 36809000161 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 36809000162 PPE family; Region: PPE; pfam00823 36809000163 Proteins of 100 residues with WXG; Region: WXG100; cl02005 36809000164 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 36809000165 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809000166 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 36809000167 nucleoside/Zn binding site; other site 36809000168 dimer interface [polypeptide binding]; other site 36809000169 catalytic motif [active] 36809000170 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809000171 cyanate hydratase; Validated; Region: PRK02866 36809000172 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 36809000173 oligomer interface [polypeptide binding]; other site 36809000174 active site 36809000175 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 36809000176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809000177 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 36809000178 dimerization interface [polypeptide binding]; other site 36809000179 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 36809000180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809000181 ATP binding site [chemical binding]; other site 36809000182 putative Mg++ binding site [ion binding]; other site 36809000183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809000184 nucleotide binding region [chemical binding]; other site 36809000185 ATP-binding site [chemical binding]; other site 36809000186 Helicase associated domain (HA2); Region: HA2; pfam04408 36809000187 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 36809000188 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 36809000189 short chain dehydrogenase; Provisional; Region: PRK07041 36809000190 classical (c) SDRs; Region: SDR_c; cd05233 36809000191 NAD(P) binding site [chemical binding]; other site 36809000192 active site 36809000193 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 36809000194 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809000195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809000196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809000197 active site 36809000198 phosphorylation site [posttranslational modification] 36809000199 intermolecular recognition site; other site 36809000200 dimerization interface [polypeptide binding]; other site 36809000201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809000202 DNA binding residues [nucleotide binding] 36809000203 dimerization interface [polypeptide binding]; other site 36809000204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 36809000205 Histidine kinase; Region: HisKA_3; pfam07730 36809000206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809000207 ATP binding site [chemical binding]; other site 36809000208 Mg2+ binding site [ion binding]; other site 36809000209 G-X-G motif; other site 36809000210 mycothione reductase; Reviewed; Region: PRK07846 36809000211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809000212 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809000213 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809000214 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809000215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809000216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809000217 active site 36809000218 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 36809000219 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 36809000220 VirB8 protein; Region: VirB8; cl01500 36809000221 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 36809000222 Transcriptional regulators [Transcription]; Region: FadR; COG2186 36809000223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809000224 DNA-binding site [nucleotide binding]; DNA binding site 36809000225 FCD domain; Region: FCD; pfam07729 36809000226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809000227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809000228 putative substrate translocation pore; other site 36809000229 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 36809000230 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 36809000231 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 36809000232 active site residue [active] 36809000233 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 36809000234 active site residue [active] 36809000235 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 36809000236 classical (c) SDRs; Region: SDR_c; cd05233 36809000237 NAD(P) binding site [chemical binding]; other site 36809000238 active site 36809000239 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 36809000240 classical (c) SDRs; Region: SDR_c; cd05233 36809000241 NAD(P) binding site [chemical binding]; other site 36809000242 active site 36809000243 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809000244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809000245 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809000246 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809000247 active site 36809000248 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 36809000249 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 36809000250 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 36809000251 active site 36809000252 Fe binding site [ion binding]; other site 36809000253 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809000254 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 36809000255 Bacterial transcriptional regulator; Region: IclR; pfam01614 36809000256 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809000257 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809000258 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 36809000259 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 36809000260 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809000261 hydrophobic ligand binding site; other site 36809000262 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 36809000263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809000264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809000265 Predicted transcriptional regulators [Transcription]; Region: COG1695 36809000266 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809000267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809000268 Uncharacterized conserved protein [Function unknown]; Region: COG5361 36809000269 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 36809000270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000271 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 36809000272 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 36809000273 alkaline phosphatase; Provisional; Region: PRK10518 36809000274 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 36809000275 active site 36809000276 dimer interface [polypeptide binding]; other site 36809000277 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 36809000278 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 36809000279 FMN-binding pocket [chemical binding]; other site 36809000280 flavin binding motif; other site 36809000281 phosphate binding motif [ion binding]; other site 36809000282 beta-alpha-beta structure motif; other site 36809000283 NAD binding pocket [chemical binding]; other site 36809000284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809000285 catalytic loop [active] 36809000286 iron binding site [ion binding]; other site 36809000287 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 36809000288 short chain dehydrogenase; Provisional; Region: PRK05650 36809000289 classical (c) SDRs; Region: SDR_c; cd05233 36809000290 NAD(P) binding site [chemical binding]; other site 36809000291 active site 36809000292 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 36809000293 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 36809000294 active site 36809000295 dimer interface [polypeptide binding]; other site 36809000296 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 36809000297 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 36809000298 active site 36809000299 FMN binding site [chemical binding]; other site 36809000300 substrate binding site [chemical binding]; other site 36809000301 3Fe-4S cluster binding site [ion binding]; other site 36809000302 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 36809000303 domain interface; other site 36809000304 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 36809000305 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 36809000306 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 36809000307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809000308 NAD(P) binding site [chemical binding]; other site 36809000309 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 36809000310 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 36809000311 active site 36809000312 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809000313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809000314 non-specific DNA binding site [nucleotide binding]; other site 36809000315 salt bridge; other site 36809000316 sequence-specific DNA binding site [nucleotide binding]; other site 36809000317 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 36809000318 hypothetical protein; Provisional; Region: PRK07945 36809000319 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 36809000320 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 36809000321 active site 36809000322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809000325 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809000326 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 36809000327 classical (c) SDRs; Region: SDR_c; cd05233 36809000328 NAD(P) binding site [chemical binding]; other site 36809000329 active site 36809000330 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809000331 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809000332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809000333 S-adenosylmethionine binding site [chemical binding]; other site 36809000334 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809000335 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809000336 enoyl-CoA hydratase; Provisional; Region: PRK08260 36809000337 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809000338 substrate binding site [chemical binding]; other site 36809000339 oxyanion hole (OAH) forming residues; other site 36809000340 trimer interface [polypeptide binding]; other site 36809000341 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 36809000342 FAD binding domain; Region: FAD_binding_4; pfam01565 36809000343 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 36809000344 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 36809000345 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 36809000346 dimer interface [polypeptide binding]; other site 36809000347 active site 36809000348 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 36809000349 substrate binding site [chemical binding]; other site 36809000350 catalytic residue [active] 36809000351 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 36809000352 CopC domain; Region: CopC; pfam04234 36809000353 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 36809000354 Domain of unknown function (DUF955); Region: DUF955; cl01076 36809000355 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809000356 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 36809000357 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 36809000358 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 36809000359 methionine sulfoxide reductase A; Provisional; Region: PRK00058 36809000360 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 36809000361 active site residue [active] 36809000362 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 36809000363 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 36809000364 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 36809000365 putative active site [active] 36809000366 catalytic site [active] 36809000367 putative metal binding site [ion binding]; other site 36809000368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 36809000369 metal binding site [ion binding]; metal-binding site 36809000370 active site 36809000371 I-site; other site 36809000372 Leucine carboxyl methyltransferase; Region: LCM; cl01306 36809000373 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 36809000374 Ferritin-like domain; Region: Ferritin; pfam00210 36809000375 ferroxidase diiron center [ion binding]; other site 36809000376 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 36809000377 Ferritin-like domain; Region: Ferritin; pfam00210 36809000378 ferroxidase diiron center [ion binding]; other site 36809000379 Transcriptional regulator [Transcription]; Region: LytR; COG1316 36809000380 CAAX protease self-immunity; Region: Abi; pfam02517 36809000381 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809000382 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809000383 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 36809000384 prephenate dehydratase; Provisional; Region: PRK11898 36809000385 Prephenate dehydratase; Region: PDT; pfam00800 36809000386 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 36809000387 putative L-Phe binding site [chemical binding]; other site 36809000388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809000389 catalytic core [active] 36809000390 pyruvate dehydrogenase; Provisional; Region: PRK09124 36809000391 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 36809000392 PYR/PP interface [polypeptide binding]; other site 36809000393 dimer interface [polypeptide binding]; other site 36809000394 tetramer interface [polypeptide binding]; other site 36809000395 TPP binding site [chemical binding]; other site 36809000396 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 36809000397 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 36809000398 TPP-binding site [chemical binding]; other site 36809000399 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809000400 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 36809000401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000403 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809000404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809000405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809000406 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809000407 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809000408 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809000409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809000410 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809000411 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 36809000412 classical (c) SDRs; Region: SDR_c; cd05233 36809000413 NAD(P) binding site [chemical binding]; other site 36809000414 active site 36809000415 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809000416 classical (c) SDRs; Region: SDR_c; cd05233 36809000417 NAD(P) binding site [chemical binding]; other site 36809000418 active site 36809000419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000421 MgtC family; Region: MgtC; pfam02308 36809000422 EspG family; Region: ESX-1_EspG; pfam14011 36809000423 PPE family; Region: PPE; pfam00823 36809000424 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 36809000425 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 36809000426 Septum formation; Region: Septum_form; pfam13845 36809000427 Septum formation; Region: Septum_form; pfam13845 36809000428 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 36809000429 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 36809000430 seryl-tRNA synthetase; Provisional; Region: PRK05431 36809000431 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 36809000432 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 36809000433 dimer interface [polypeptide binding]; other site 36809000434 active site 36809000435 motif 1; other site 36809000436 motif 2; other site 36809000437 motif 3; other site 36809000438 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 36809000439 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 36809000440 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 36809000441 iron-sulfur cluster [ion binding]; other site 36809000442 [2Fe-2S] cluster binding site [ion binding]; other site 36809000443 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809000444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809000445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809000446 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 36809000447 Walker A/P-loop; other site 36809000448 ATP binding site [chemical binding]; other site 36809000449 Q-loop/lid; other site 36809000450 ABC transporter signature motif; other site 36809000451 Walker B; other site 36809000452 D-loop; other site 36809000453 H-loop/switch region; other site 36809000454 Nitronate monooxygenase; Region: NMO; pfam03060 36809000455 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 36809000456 FMN binding site [chemical binding]; other site 36809000457 putative catalytic residue [active] 36809000458 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 36809000459 Tautomerase enzyme; Region: Tautomerase_2; pfam14552 36809000460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809000461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809000462 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 36809000463 putative dimerization interface [polypeptide binding]; other site 36809000464 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 36809000465 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 36809000466 Phosphotransferase enzyme family; Region: APH; pfam01636 36809000467 active site 36809000468 ATP binding site [chemical binding]; other site 36809000469 substrate binding site [chemical binding]; other site 36809000470 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 36809000471 classical (c) SDRs; Region: SDR_c; cd05233 36809000472 NAD(P) binding site [chemical binding]; other site 36809000473 active site 36809000474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 36809000475 putative acyl-acceptor binding pocket; other site 36809000476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 36809000477 putative acyl-acceptor binding pocket; other site 36809000478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809000479 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 36809000480 active site 36809000481 motif I; other site 36809000482 motif II; other site 36809000483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809000484 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 36809000485 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 36809000486 amidase catalytic site [active] 36809000487 Zn binding residues [ion binding]; other site 36809000488 substrate binding site [chemical binding]; other site 36809000489 LGFP repeat; Region: LGFP; pfam08310 36809000490 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 36809000491 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 36809000492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809000493 UDP-galactopyranose mutase; Region: GLF; pfam03275 36809000494 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 36809000495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 36809000496 active site 36809000497 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 36809000498 active site 36809000499 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 36809000500 putative active site [active] 36809000501 Predicted esterase [General function prediction only]; Region: COG0627 36809000502 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809000503 Predicted esterase [General function prediction only]; Region: COG0627 36809000504 S-formylglutathione hydrolase; Region: PLN02442 36809000505 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809000506 Predicted esterase [General function prediction only]; Region: COG0627 36809000507 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809000508 Cutinase; Region: Cutinase; pfam01083 36809000509 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 36809000510 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809000511 acyl-activating enzyme (AAE) consensus motif; other site 36809000512 active site 36809000513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809000514 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809000515 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 36809000516 active site 36809000517 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809000518 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 36809000519 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 36809000520 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 36809000521 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 36809000522 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809000523 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 36809000524 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 36809000525 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 36809000526 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 36809000527 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 36809000528 AAA ATPase domain; Region: AAA_16; pfam13191 36809000529 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 36809000530 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 36809000531 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 36809000532 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 36809000533 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809000534 classical (c) SDRs; Region: SDR_c; cd05233 36809000535 NAD(P) binding site [chemical binding]; other site 36809000536 active site 36809000537 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 36809000538 FAD binding domain; Region: FAD_binding_4; pfam01565 36809000539 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 36809000540 Predicted membrane protein [Function unknown]; Region: COG2246 36809000541 dihydroxyacetone kinase; Provisional; Region: PRK14479 36809000542 Dak1 domain; Region: Dak1; cl10557 36809000543 DAK2 domain; Region: Dak2; pfam02734 36809000544 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809000545 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809000546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809000547 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 36809000548 DNA-binding site [nucleotide binding]; DNA binding site 36809000549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809000550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809000551 homodimer interface [polypeptide binding]; other site 36809000552 catalytic residue [active] 36809000553 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809000554 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809000555 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 36809000556 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 36809000557 active site 36809000558 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 36809000559 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 36809000560 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 36809000561 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 36809000562 active site 36809000563 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 36809000564 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 36809000565 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 36809000566 active site 36809000567 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 36809000568 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 36809000569 Walker A/P-loop; other site 36809000570 ATP binding site [chemical binding]; other site 36809000571 Q-loop/lid; other site 36809000572 ABC transporter signature motif; other site 36809000573 Walker B; other site 36809000574 D-loop; other site 36809000575 H-loop/switch region; other site 36809000576 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 36809000577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 36809000578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809000579 catalytic residue [active] 36809000580 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 36809000581 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 36809000582 NAD(P) binding site [chemical binding]; other site 36809000583 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809000584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809000585 putative DNA binding site [nucleotide binding]; other site 36809000586 putative Zn2+ binding site [ion binding]; other site 36809000587 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 36809000588 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 36809000589 Leucine carboxyl methyltransferase; Region: LCM; cl01306 36809000590 OsmC-like protein; Region: OsmC; pfam02566 36809000591 Predicted transcriptional regulator [Transcription]; Region: COG2345 36809000592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809000593 putative DNA binding site [nucleotide binding]; other site 36809000594 dimerization interface [polypeptide binding]; other site 36809000595 putative Zn2+ binding site [ion binding]; other site 36809000596 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 36809000597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809000598 catalytic residue [active] 36809000599 TQXA domain; Region: TQXA_dom; TIGR03934 36809000600 putative aminotransferase; Provisional; Region: PRK03321 36809000601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809000603 homodimer interface [polypeptide binding]; other site 36809000604 catalytic residue [active] 36809000605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 36809000606 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 36809000607 active site 36809000608 DNA binding site [nucleotide binding] 36809000609 Int/Topo IB signature motif; other site 36809000610 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 36809000611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809000612 Helix-turn-helix domain; Region: HTH_17; pfam12728 36809000613 Phage-related minor tail protein [Function unknown]; Region: COG5280 36809000614 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 36809000615 Protein of unknown function (DUF996); Region: DUF996; cl00970 36809000616 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809000617 active site 36809000618 Protein of unknown function (DUF1451); Region: DUF1451; cl19727 36809000619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809000620 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809000621 S-adenosylmethionine binding site [chemical binding]; other site 36809000622 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 36809000623 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 36809000624 putative hydrophobic ligand binding site [chemical binding]; other site 36809000625 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 36809000626 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 36809000627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000628 choline dehydrogenase; Validated; Region: PRK02106 36809000629 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809000630 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 36809000631 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 36809000632 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809000633 catalytic core [active] 36809000634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809000635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809000636 active site 36809000637 Uncharacterized conserved protein [Function unknown]; Region: COG2966 36809000638 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 36809000639 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 36809000640 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 36809000641 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 36809000642 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 36809000643 short chain dehydrogenase; Provisional; Region: PRK07890 36809000644 classical (c) SDRs; Region: SDR_c; cd05233 36809000645 NAD(P) binding site [chemical binding]; other site 36809000646 active site 36809000647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000649 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 36809000650 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 36809000651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809000652 Walker A/P-loop; other site 36809000653 ATP binding site [chemical binding]; other site 36809000654 Q-loop/lid; other site 36809000655 ABC transporter signature motif; other site 36809000656 Walker B; other site 36809000657 D-loop; other site 36809000658 H-loop/switch region; other site 36809000659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809000660 dimer interface [polypeptide binding]; other site 36809000661 conserved gate region; other site 36809000662 putative PBP binding loops; other site 36809000663 ABC-ATPase subunit interface; other site 36809000664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809000665 ABC-ATPase subunit interface; other site 36809000666 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 36809000667 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 36809000668 prephenate dehydrogenase; Validated; Region: PRK08507 36809000669 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 36809000670 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 36809000671 nucleoside/Zn binding site; other site 36809000672 dimer interface [polypeptide binding]; other site 36809000673 catalytic motif [active] 36809000674 GXWXG protein; Region: GXWXG; pfam14231 36809000675 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 36809000676 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 36809000677 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 36809000678 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809000679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 36809000680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 36809000681 substrate binding pocket [chemical binding]; other site 36809000682 membrane-bound complex binding site; other site 36809000683 hinge residues; other site 36809000684 amino acid ABC transporter permease; Provisional; Region: PRK15100 36809000685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809000686 dimer interface [polypeptide binding]; other site 36809000687 conserved gate region; other site 36809000688 putative PBP binding loops; other site 36809000689 ABC-ATPase subunit interface; other site 36809000690 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 36809000691 active site 36809000692 nucleotide binding site [chemical binding]; other site 36809000693 HIGH motif; other site 36809000694 KMSKS motif; other site 36809000695 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 36809000696 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 36809000697 active site 36809000698 DNA binding site [nucleotide binding] 36809000699 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 36809000700 DNA binding site [nucleotide binding] 36809000701 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 36809000702 nucleotide binding site [chemical binding]; other site 36809000703 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 36809000704 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 36809000705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809000706 putative substrate translocation pore; other site 36809000707 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809000708 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 36809000709 NAD(P) binding site [chemical binding]; other site 36809000710 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 36809000711 hydrophobic ligand binding site; other site 36809000712 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 36809000713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809000714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809000715 acyl-activating enzyme (AAE) consensus motif; other site 36809000716 acyl-activating enzyme (AAE) consensus motif; other site 36809000717 AMP binding site [chemical binding]; other site 36809000718 active site 36809000719 CoA binding site [chemical binding]; other site 36809000720 salicylate hydroxylase; Provisional; Region: PRK08163 36809000721 Squalene epoxidase; Region: SE; cl17314 36809000722 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 36809000723 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 36809000724 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 36809000725 tetramer interface [polypeptide binding]; other site 36809000726 GAF domain; Region: GAF; pfam01590 36809000727 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809000728 DDE superfamily endonuclease; Region: DDE_5; cl17874 36809000729 Carboxylesterase family; Region: COesterase; pfam00135 36809000730 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809000731 substrate binding pocket [chemical binding]; other site 36809000732 catalytic triad [active] 36809000733 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 36809000734 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 36809000735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809000736 NAD(P) binding site [chemical binding]; other site 36809000737 active site 36809000738 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 36809000739 catalytic triad [active] 36809000740 conserved cis-peptide bond; other site 36809000741 isochorismate synthase DhbC; Validated; Region: PRK06923 36809000742 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 36809000743 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 36809000744 Glutamine amidotransferase class-I; Region: GATase; pfam00117 36809000745 glutamine binding [chemical binding]; other site 36809000746 catalytic triad [active] 36809000747 Amidohydrolase; Region: Amidohydro_2; pfam04909 36809000748 active site 36809000749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000751 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 36809000752 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809000753 substrate binding pocket [chemical binding]; other site 36809000754 catalytic triad [active] 36809000755 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 36809000756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809000757 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809000758 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 36809000759 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 36809000760 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809000761 catalytic residue [active] 36809000762 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 36809000763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809000764 Walker A motif; other site 36809000765 ATP binding site [chemical binding]; other site 36809000766 Walker B motif; other site 36809000767 arginine finger; other site 36809000768 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 36809000769 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 36809000770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809000771 S-adenosylmethionine binding site [chemical binding]; other site 36809000772 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 36809000773 FAD binding domain; Region: FAD_binding_4; cl19922 36809000774 enolase; Provisional; Region: eno; PRK00077 36809000775 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 36809000776 metal binding site [ion binding]; metal-binding site 36809000777 substrate binding pocket [chemical binding]; other site 36809000778 Phosphotransferase enzyme family; Region: APH; pfam01636 36809000779 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 36809000780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809000783 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809000784 active site 36809000785 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 36809000786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809000787 substrate binding site [chemical binding]; other site 36809000788 oxyanion hole (OAH) forming residues; other site 36809000789 trimer interface [polypeptide binding]; other site 36809000790 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 36809000791 hydrophobic ligand binding site; other site 36809000792 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 36809000793 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 36809000794 active site 36809000795 metal binding site [ion binding]; metal-binding site 36809000796 hypothetical protein; Validated; Region: PRK00153 36809000797 recombination protein RecR; Reviewed; Region: recR; PRK00076 36809000798 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 36809000799 RecR protein; Region: RecR; pfam02132 36809000800 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 36809000801 putative active site [active] 36809000802 putative metal-binding site [ion binding]; other site 36809000803 tetramer interface [polypeptide binding]; other site 36809000804 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 36809000805 catalytic triad [active] 36809000806 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 36809000807 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 36809000808 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 36809000809 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809000810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809000811 Phosphotransferase enzyme family; Region: APH; pfam01636 36809000812 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 36809000813 putative active site [active] 36809000814 putative substrate binding site [chemical binding]; other site 36809000815 ATP binding site [chemical binding]; other site 36809000816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809000817 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809000818 active site 36809000819 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 36809000820 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 36809000821 active site 36809000822 catalytic site [active] 36809000823 substrate binding site [chemical binding]; other site 36809000824 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809000825 30S ribosomal protein S18; Provisional; Region: PRK13401 36809000826 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 36809000827 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 36809000828 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 36809000829 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 36809000830 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809000831 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 36809000832 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 36809000833 2-isopropylmalate synthase; Validated; Region: PRK03739 36809000834 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 36809000835 active site 36809000836 catalytic residues [active] 36809000837 metal binding site [ion binding]; metal-binding site 36809000838 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 36809000839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000841 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 36809000842 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 36809000843 FMN binding site [chemical binding]; other site 36809000844 dimer interface [polypeptide binding]; other site 36809000845 aspartate kinase; Reviewed; Region: PRK06635 36809000846 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 36809000847 putative nucleotide binding site [chemical binding]; other site 36809000848 putative catalytic residues [active] 36809000849 putative Mg ion binding site [ion binding]; other site 36809000850 putative aspartate binding site [chemical binding]; other site 36809000851 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 36809000852 putative allosteric regulatory site; other site 36809000853 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 36809000854 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 36809000855 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 36809000856 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 36809000857 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 36809000858 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 36809000859 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 36809000860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809000861 Walker A motif; other site 36809000862 ATP binding site [chemical binding]; other site 36809000863 Walker B motif; other site 36809000864 arginine finger; other site 36809000865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 36809000866 TPR motif; other site 36809000867 binding surface 36809000868 TPR repeat; Region: TPR_11; pfam13414 36809000869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 36809000870 binding surface 36809000871 TPR motif; other site 36809000872 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809000873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809000874 TAP-like protein; Region: Abhydrolase_4; pfam08386 36809000875 Protein of unknown function, DUF486; Region: DUF486; cl01236 36809000876 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 36809000877 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 36809000878 tetramer interface [polypeptide binding]; other site 36809000879 heme binding pocket [chemical binding]; other site 36809000880 NADPH binding site [chemical binding]; other site 36809000881 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809000882 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809000883 Nitronate monooxygenase; Region: NMO; pfam03060 36809000884 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 36809000885 FMN binding site [chemical binding]; other site 36809000886 putative catalytic residue [active] 36809000887 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 36809000888 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 36809000889 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 36809000890 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809000891 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 36809000892 substrate binding site [chemical binding]; other site 36809000893 ATP binding site [chemical binding]; other site 36809000894 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809000895 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809000896 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 36809000897 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 36809000898 active site 36809000899 dimer interface [polypeptide binding]; other site 36809000900 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 36809000901 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 36809000902 dimer interface [polypeptide binding]; other site 36809000903 active site 36809000904 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 36809000905 dimer interface [polypeptide binding]; other site 36809000906 active site 36809000907 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 36809000908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809000909 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 36809000910 putative substrate translocation pore; other site 36809000911 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 36809000912 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 36809000913 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 36809000914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809000915 NAD(P) binding site [chemical binding]; other site 36809000916 active site 36809000917 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 36809000918 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 36809000919 DinB superfamily; Region: DinB_2; pfam12867 36809000920 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 36809000921 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 36809000922 putative active site [active] 36809000923 putative dimer interface [polypeptide binding]; other site 36809000924 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 36809000925 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 36809000926 ergothioneine biosynthesis PLP-dependent enzyme EgtE; Region: egtE_PLP_lyase; TIGR04343 36809000927 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 36809000928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809000929 catalytic residue [active] 36809000930 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 36809000931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809000932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809000933 lipid-transfer protein; Provisional; Region: PRK08256 36809000934 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809000935 active site 36809000936 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809000937 active site 36809000938 catalytic site [active] 36809000939 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809000940 active site 2 [active] 36809000941 active site 1 [active] 36809000942 short chain dehydrogenase; Provisional; Region: PRK07791 36809000943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809000944 NAD(P) binding site [chemical binding]; other site 36809000945 active site 36809000946 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 36809000947 amphipathic channel; other site 36809000948 Asn-Pro-Ala signature motifs; other site 36809000949 glycerol kinase; Provisional; Region: glpK; PRK00047 36809000950 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 36809000951 nucleotide binding site [chemical binding]; other site 36809000952 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 36809000953 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 36809000954 Predicted membrane protein/domain [Function unknown]; Region: COG1714 36809000955 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 36809000956 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 36809000957 Protein of unknown function DUF58; Region: DUF58; pfam01882 36809000958 MoxR-like ATPases [General function prediction only]; Region: COG0714 36809000959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809000960 Walker A motif; other site 36809000961 ATP binding site [chemical binding]; other site 36809000962 Walker B motif; other site 36809000963 arginine finger; other site 36809000964 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 36809000965 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 36809000966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809000967 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809000968 S-adenosylmethionine binding site [chemical binding]; other site 36809000969 Domain of unknown function (DUF222); Region: DUF222; pfam02720 36809000970 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809000971 active site 36809000972 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 36809000973 minor groove reading motif; other site 36809000974 helix-hairpin-helix signature motif; other site 36809000975 active site 36809000976 HNH endonuclease; Region: HNH_2; pfam13391 36809000977 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 36809000978 AAA domain; Region: AAA_30; pfam13604 36809000979 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 36809000980 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 36809000981 Part of AAA domain; Region: AAA_19; pfam13245 36809000982 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 36809000983 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 36809000984 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 36809000985 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809000986 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 36809000987 active site 36809000988 catalytic triad [active] 36809000989 oxyanion hole [active] 36809000990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809000991 Coenzyme A binding pocket [chemical binding]; other site 36809000992 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 36809000993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809000994 catalytic residue [active] 36809000995 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 36809000996 putative active site [active] 36809000997 putative metal binding site [ion binding]; other site 36809000998 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 36809000999 Transglycosylase; Region: Transgly; pfam00912 36809001000 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 36809001001 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 36809001002 Transcription factor WhiB; Region: Whib; pfam02467 36809001003 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 36809001004 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 36809001005 P loop; other site 36809001006 Nucleotide binding site [chemical binding]; other site 36809001007 DTAP/Switch II; other site 36809001008 Switch I; other site 36809001009 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 36809001010 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 36809001011 P loop; other site 36809001012 Nucleotide binding site [chemical binding]; other site 36809001013 DTAP/Switch II; other site 36809001014 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 36809001015 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 36809001016 homotrimer interaction site [polypeptide binding]; other site 36809001017 putative active site [active] 36809001018 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809001019 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 36809001020 EamA-like transporter family; Region: EamA; pfam00892 36809001021 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 36809001022 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 36809001023 ligand binding site [chemical binding]; other site 36809001024 flexible hinge region; other site 36809001025 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 36809001026 putative switch regulator; other site 36809001027 non-specific DNA interactions [nucleotide binding]; other site 36809001028 DNA binding site [nucleotide binding] 36809001029 sequence specific DNA binding site [nucleotide binding]; other site 36809001030 putative cAMP binding site [chemical binding]; other site 36809001031 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 36809001032 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 36809001033 minor groove reading motif; other site 36809001034 helix-hairpin-helix signature motif; other site 36809001035 substrate binding pocket [chemical binding]; other site 36809001036 active site 36809001037 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 36809001038 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 36809001039 catalytic residues [active] 36809001040 vWA found in TerF C terminus; Region: vWA-TerF-like; pfam10138 36809001041 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 36809001042 putative active site [active] 36809001043 putative CoA binding site [chemical binding]; other site 36809001044 nudix motif; other site 36809001045 metal binding site [ion binding]; metal-binding site 36809001046 Colicin V production protein; Region: Colicin_V; pfam02674 36809001047 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 36809001048 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 36809001049 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809001050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809001051 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 36809001052 acetyl-CoA synthetase; Provisional; Region: PRK00174 36809001053 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 36809001054 active site 36809001055 CoA binding site [chemical binding]; other site 36809001056 acyl-activating enzyme (AAE) consensus motif; other site 36809001057 AMP binding site [chemical binding]; other site 36809001058 acetate binding site [chemical binding]; other site 36809001059 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 36809001060 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 36809001061 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 36809001062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809001063 dimer interface [polypeptide binding]; other site 36809001064 conserved gate region; other site 36809001065 putative PBP binding loops; other site 36809001066 ABC-ATPase subunit interface; other site 36809001067 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 36809001068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809001069 dimer interface [polypeptide binding]; other site 36809001070 conserved gate region; other site 36809001071 putative PBP binding loops; other site 36809001072 ABC-ATPase subunit interface; other site 36809001073 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 36809001074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 36809001075 Walker A/P-loop; other site 36809001076 ATP binding site [chemical binding]; other site 36809001077 Q-loop/lid; other site 36809001078 ABC transporter signature motif; other site 36809001079 Walker B; other site 36809001080 D-loop; other site 36809001081 H-loop/switch region; other site 36809001082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 36809001083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 36809001084 Walker A/P-loop; other site 36809001085 ATP binding site [chemical binding]; other site 36809001086 Q-loop/lid; other site 36809001087 ABC transporter signature motif; other site 36809001088 Walker B; other site 36809001089 D-loop; other site 36809001090 H-loop/switch region; other site 36809001091 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 36809001092 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 36809001093 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 36809001094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809001095 motif II; other site 36809001096 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 36809001097 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 36809001098 Walker A motif; other site 36809001099 ATP binding site [chemical binding]; other site 36809001100 Walker B motif; other site 36809001101 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809001102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809001103 non-specific DNA binding site [nucleotide binding]; other site 36809001104 salt bridge; other site 36809001105 sequence-specific DNA binding site [nucleotide binding]; other site 36809001106 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 36809001107 Domain of unknown function (DUF955); Region: DUF955; cl01076 36809001108 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 36809001109 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 36809001110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 36809001111 active site 36809001112 DNA binding site [nucleotide binding] 36809001113 Int/Topo IB signature motif; other site 36809001114 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 36809001115 active site 36809001116 Int/Topo IB signature motif; other site 36809001117 catalytic residues [active] 36809001118 DNA binding site [nucleotide binding] 36809001119 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 36809001120 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 36809001121 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 36809001122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809001123 motif II; other site 36809001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809001125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809001126 putative substrate translocation pore; other site 36809001127 cysteine synthase; Region: PLN02565 36809001128 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 36809001129 dimer interface [polypeptide binding]; other site 36809001130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809001131 catalytic residue [active] 36809001132 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 36809001133 metal-binding site [ion binding] 36809001134 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 36809001135 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 36809001136 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 36809001137 NodB motif; other site 36809001138 active site 36809001139 catalytic site [active] 36809001140 metal binding site [ion binding]; metal-binding site 36809001141 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 36809001142 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 36809001143 The first cupredoxin domain of CumA like multicopper oxidase; Region: CuRO_1_CumA_like; cd13861 36809001144 putative Domain 2 interface [polypeptide binding]; other site 36809001145 putative Domain 3 interface [polypeptide binding]; other site 36809001146 trinuclear Cu binding site [ion binding]; other site 36809001147 The second cupredoxin domain of CopA copper resistance protein like family; Region: CuRO_2_CopA_like_1; cd13870 36809001148 putative Domain 1 interface [polypeptide binding]; other site 36809001149 putative Domain 3 interface [polypeptide binding]; other site 36809001150 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 36809001151 putative Domain 2 interface [polypeptide binding]; other site 36809001152 Type 1 (T1) Cu binding site [ion binding]; other site 36809001153 putative Domain 1 interface [polypeptide binding]; other site 36809001154 trinuclear Cu binding site [ion binding]; other site 36809001155 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 36809001156 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 36809001157 active site clefts [active] 36809001158 zinc binding site [ion binding]; other site 36809001159 dimer interface [polypeptide binding]; other site 36809001160 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809001161 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809001162 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 36809001163 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 36809001164 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 36809001165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001167 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809001168 Transport protein; Region: actII; TIGR00833 36809001169 MMPL family; Region: MMPL; pfam03176 36809001170 MMPL family; Region: MMPL; pfam03176 36809001171 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809001172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809001173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809001174 NAD(P) binding site [chemical binding]; other site 36809001175 active site 36809001176 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 36809001177 active site 36809001178 catalytic triad [active] 36809001179 dimer interface [polypeptide binding]; other site 36809001180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001182 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809001183 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809001184 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 36809001185 active site 36809001186 FMN binding site [chemical binding]; other site 36809001187 substrate binding site [chemical binding]; other site 36809001188 homotetramer interface [polypeptide binding]; other site 36809001189 catalytic residue [active] 36809001190 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 36809001191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809001192 ATP binding site [chemical binding]; other site 36809001193 putative Mg++ binding site [ion binding]; other site 36809001194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809001195 nucleotide binding region [chemical binding]; other site 36809001196 ATP-binding site [chemical binding]; other site 36809001197 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 36809001198 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 36809001199 DNA-binding site [nucleotide binding]; DNA binding site 36809001200 RNA-binding motif; other site 36809001201 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 36809001202 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 36809001203 active site 36809001204 interdomain interaction site; other site 36809001205 putative metal-binding site [ion binding]; other site 36809001206 nucleotide binding site [chemical binding]; other site 36809001207 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 36809001208 domain I; other site 36809001209 DNA binding groove [nucleotide binding] 36809001210 phosphate binding site [ion binding]; other site 36809001211 domain II; other site 36809001212 domain III; other site 36809001213 nucleotide binding site [chemical binding]; other site 36809001214 catalytic site [active] 36809001215 domain IV; other site 36809001216 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 36809001217 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 36809001218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809001219 dimerization interface [polypeptide binding]; other site 36809001220 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 36809001221 cyclase homology domain; Region: CHD; cd07302 36809001222 nucleotidyl binding site; other site 36809001223 metal binding site [ion binding]; metal-binding site 36809001224 dimer interface [polypeptide binding]; other site 36809001225 DNA polymerase III subunit delta'; Validated; Region: PRK07940 36809001226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809001227 Walker A motif; other site 36809001228 ATP binding site [chemical binding]; other site 36809001229 Walker B motif; other site 36809001230 arginine finger; other site 36809001231 Domain of unknown function (DUF955); Region: DUF955; cl01076 36809001232 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 36809001233 CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864 36809001234 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809001235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809001236 sequence-specific DNA binding site [nucleotide binding]; other site 36809001237 salt bridge; other site 36809001238 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 36809001239 CAAX protease self-immunity; Region: Abi; pfam02517 36809001240 Predicted membrane protein [Function unknown]; Region: COG4270 36809001241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001243 WHG domain; Region: WHG; pfam13305 36809001244 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 36809001245 Predicted acyl esterases [General function prediction only]; Region: COG2936 36809001246 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 36809001247 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809001248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809001249 NAD(P) binding site [chemical binding]; other site 36809001250 active site 36809001251 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 36809001252 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 36809001253 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 36809001254 Ligand binding site; other site 36809001255 Putative Catalytic site; other site 36809001256 DXD motif; other site 36809001257 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 36809001258 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 36809001259 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 36809001260 Zn binding site [ion binding]; other site 36809001261 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 36809001262 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 36809001263 acyl-activating enzyme (AAE) consensus motif; other site 36809001264 AMP binding site [chemical binding]; other site 36809001265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809001266 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 36809001267 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 36809001268 putative trimer interface [polypeptide binding]; other site 36809001269 putative CoA binding site [chemical binding]; other site 36809001270 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 36809001271 putative trimer interface [polypeptide binding]; other site 36809001272 putative CoA binding site [chemical binding]; other site 36809001273 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 36809001274 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 36809001275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809001276 catalytic residue [active] 36809001277 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809001278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809001279 short chain dehydrogenase; Provisional; Region: PRK08267 36809001280 classical (c) SDRs; Region: SDR_c; cd05233 36809001281 NAD(P) binding site [chemical binding]; other site 36809001282 active site 36809001283 putative OHCU decarboxylase; Provisional; Region: PRK13798 36809001284 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809001285 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 36809001286 dimer interface [polypeptide binding]; other site 36809001287 substrate binding site [chemical binding]; other site 36809001288 metal binding sites [ion binding]; metal-binding site 36809001289 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 36809001290 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 36809001291 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 36809001292 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 36809001293 Ligand Binding Site [chemical binding]; other site 36809001294 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809001295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809001296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809001297 active site 36809001298 Protein of unknown function (DUF541); Region: SIMPL; cl01077 36809001299 Protein of unknown function (DUF541); Region: SIMPL; cl01077 36809001300 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 36809001301 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 36809001302 putative NAD(P) binding site [chemical binding]; other site 36809001303 catalytic Zn binding site [ion binding]; other site 36809001304 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 36809001305 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809001306 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809001307 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809001308 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 36809001309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001311 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 36809001312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 36809001313 metal ion-dependent adhesion site (MIDAS); other site 36809001314 FtsH Extracellular; Region: FtsH_ext; pfam06480 36809001315 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 36809001316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809001317 Walker A motif; other site 36809001318 ATP binding site [chemical binding]; other site 36809001319 Walker B motif; other site 36809001320 arginine finger; other site 36809001321 Peptidase family M41; Region: Peptidase_M41; pfam01434 36809001322 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 36809001323 active site 36809001324 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 36809001325 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 36809001326 substrate binding pocket [chemical binding]; other site 36809001327 dimer interface [polypeptide binding]; other site 36809001328 inhibitor binding site; inhibition site 36809001329 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 36809001330 homooctamer interface [polypeptide binding]; other site 36809001331 active site 36809001332 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 36809001333 catalytic center binding site [active] 36809001334 ATP binding site [chemical binding]; other site 36809001335 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 36809001336 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 36809001337 Uncharacterized conserved protein [Function unknown]; Region: COG5495 36809001338 Rossmann-like domain; Region: Rossmann-like; pfam10727 36809001339 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 36809001340 Pantoate-beta-alanine ligase; Region: PanC; cd00560 36809001341 active site 36809001342 ATP-binding site [chemical binding]; other site 36809001343 pantoate-binding site; other site 36809001344 HXXH motif; other site 36809001345 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 36809001346 tetramerization interface [polypeptide binding]; other site 36809001347 active site 36809001348 pantothenate kinase; Reviewed; Region: PRK13318 36809001349 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 36809001350 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 36809001351 dimer interface [polypeptide binding]; other site 36809001352 putative anticodon binding site; other site 36809001353 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 36809001354 motif 1; other site 36809001355 dimer interface [polypeptide binding]; other site 36809001356 active site 36809001357 motif 2; other site 36809001358 motif 3; other site 36809001359 Lsr2; Region: Lsr2; pfam11774 36809001360 Clp protease ATP binding subunit; Region: clpC; CHL00095 36809001361 Clp amino terminal domain; Region: Clp_N; pfam02861 36809001362 Clp amino terminal domain; Region: Clp_N; pfam02861 36809001363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809001364 Walker A motif; other site 36809001365 ATP binding site [chemical binding]; other site 36809001366 Walker B motif; other site 36809001367 arginine finger; other site 36809001368 UvrB/uvrC motif; Region: UVR; pfam02151 36809001369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809001370 Walker A motif; other site 36809001371 ATP binding site [chemical binding]; other site 36809001372 Walker B motif; other site 36809001373 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 36809001374 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 36809001375 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 36809001376 intersubunit interface [polypeptide binding]; other site 36809001377 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 36809001378 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 36809001379 Walker A/P-loop; other site 36809001380 ATP binding site [chemical binding]; other site 36809001381 Q-loop/lid; other site 36809001382 ABC transporter signature motif; other site 36809001383 Walker B; other site 36809001384 D-loop; other site 36809001385 H-loop/switch region; other site 36809001386 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 36809001387 ABC-ATPase subunit interface; other site 36809001388 dimer interface [polypeptide binding]; other site 36809001389 putative PBP binding regions; other site 36809001390 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 36809001391 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 36809001392 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 36809001393 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 36809001394 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 36809001395 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809001396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809001397 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 36809001398 catalytic site [active] 36809001399 Phosphoesterase family; Region: Phosphoesterase; pfam04185 36809001400 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 36809001401 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 36809001402 conserved cys residue [active] 36809001403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809001404 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 36809001405 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 36809001406 minor groove reading motif; other site 36809001407 helix-hairpin-helix signature motif; other site 36809001408 substrate binding pocket [chemical binding]; other site 36809001409 active site 36809001410 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 36809001411 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 36809001412 active site clefts [active] 36809001413 zinc binding site [ion binding]; other site 36809001414 dimer interface [polypeptide binding]; other site 36809001415 Transcriptional regulator [Transcription]; Region: LytR; COG1316 36809001416 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 36809001417 ribonuclease III; Reviewed; Region: PRK12372 36809001418 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 36809001419 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 36809001420 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 36809001421 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 36809001422 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809001423 CoenzymeA binding site [chemical binding]; other site 36809001424 subunit interaction site [polypeptide binding]; other site 36809001425 PHB binding site; other site 36809001426 DNA repair protein RadA; Provisional; Region: PRK11823 36809001427 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 36809001428 Walker A motif; other site 36809001429 ATP binding site [chemical binding]; other site 36809001430 Walker B motif; other site 36809001431 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 36809001432 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809001433 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809001434 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 36809001435 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 36809001436 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 36809001437 substrate binding site; other site 36809001438 dimer interface; other site 36809001439 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 36809001440 homotrimer interaction site [polypeptide binding]; other site 36809001441 zinc binding site [ion binding]; other site 36809001442 CDP-binding sites; other site 36809001443 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 36809001444 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 36809001445 active site 36809001446 HIGH motif; other site 36809001447 KMSKS motif; other site 36809001448 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 36809001449 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 36809001450 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 36809001451 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 36809001452 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 36809001453 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 36809001454 active site 36809001455 catalytic site [active] 36809001456 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 36809001457 putative active site [active] 36809001458 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 36809001459 dimer interface [polypeptide binding]; other site 36809001460 putative PBP binding regions; other site 36809001461 ABC-ATPase subunit interface; other site 36809001462 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 36809001463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809001464 Walker A/P-loop; other site 36809001465 ATP binding site [chemical binding]; other site 36809001466 Q-loop/lid; other site 36809001467 ABC transporter signature motif; other site 36809001468 Walker B; other site 36809001469 D-loop; other site 36809001470 H-loop/switch region; other site 36809001471 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 36809001472 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 36809001473 intersubunit interface [polypeptide binding]; other site 36809001474 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 36809001475 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 36809001476 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 36809001477 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 36809001478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809001481 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001483 active site 36809001484 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 36809001485 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 36809001486 FAD binding pocket [chemical binding]; other site 36809001487 FAD binding motif [chemical binding]; other site 36809001488 phosphate binding motif [ion binding]; other site 36809001489 beta-alpha-beta structure motif; other site 36809001490 NAD(p) ribose binding residues [chemical binding]; other site 36809001491 NAD binding pocket [chemical binding]; other site 36809001492 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 36809001493 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809001494 catalytic loop [active] 36809001495 iron binding site [ion binding]; other site 36809001496 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809001497 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 36809001498 Flavin binding site [chemical binding]; other site 36809001499 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 36809001500 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 36809001501 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 36809001502 active site 36809001503 Fe binding site [ion binding]; other site 36809001504 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 36809001505 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 36809001506 Amidinotransferase; Region: Amidinotransf; cl19186 36809001507 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 36809001508 amphipathic channel; other site 36809001509 Asn-Pro-Ala signature motifs; other site 36809001510 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 36809001511 Predicted membrane protein [Function unknown]; Region: COG4270 36809001512 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 36809001513 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 36809001514 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809001516 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 36809001517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001518 active site 36809001519 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809001520 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001521 active site 36809001522 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 36809001523 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 36809001524 acyl-activating enzyme (AAE) consensus motif; other site 36809001525 putative AMP binding site [chemical binding]; other site 36809001526 putative active site [active] 36809001527 putative CoA binding site [chemical binding]; other site 36809001528 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001529 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 36809001530 active site 36809001531 short chain dehydrogenase; Provisional; Region: PRK07831 36809001532 classical (c) SDRs; Region: SDR_c; cd05233 36809001533 NAD(P) binding site [chemical binding]; other site 36809001534 active site 36809001535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001537 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 36809001538 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809001539 dimer interface [polypeptide binding]; other site 36809001540 active site 36809001541 Nitronate monooxygenase; Region: NMO; pfam03060 36809001542 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 36809001543 FMN binding site [chemical binding]; other site 36809001544 Coenzyme A transferase; Region: CoA_trans; cl17247 36809001545 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 36809001546 enoyl-CoA hydratase; Provisional; Region: PRK07938 36809001547 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809001548 substrate binding site [chemical binding]; other site 36809001549 oxyanion hole (OAH) forming residues; other site 36809001550 trimer interface [polypeptide binding]; other site 36809001551 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 36809001552 classical (c) SDRs; Region: SDR_c; cd05233 36809001553 NAD(P) binding site [chemical binding]; other site 36809001554 active site 36809001555 short chain dehydrogenase; Provisional; Region: PRK07791 36809001556 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 36809001557 homodimer interface [polypeptide binding]; other site 36809001558 NAD binding site [chemical binding]; other site 36809001559 active site 36809001560 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809001561 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809001562 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 36809001563 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809001564 dimer interface [polypeptide binding]; other site 36809001565 active site 36809001566 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809001567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809001568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001569 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809001570 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809001571 active site 36809001572 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809001573 active site 36809001574 catalytic site [active] 36809001575 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 36809001576 DUF35 OB-fold domain; Region: DUF35; pfam01796 36809001577 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 36809001578 putative active site [active] 36809001579 putative catalytic site [active] 36809001580 lipid-transfer protein; Provisional; Region: PRK07855 36809001581 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809001582 active site 36809001583 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 36809001584 enoyl-CoA hydratase; Region: PLN02864 36809001585 N-terminal half of MaoC dehydratase; Region: MaoC_dehydrat_N; pfam13452 36809001586 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 36809001587 dimer interaction site [polypeptide binding]; other site 36809001588 substrate-binding tunnel; other site 36809001589 active site 36809001590 catalytic site [active] 36809001591 substrate binding site [chemical binding]; other site 36809001592 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 36809001593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809001594 hypothetical protein; Validated; Region: PRK07121 36809001595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809001596 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 36809001597 acetaldehyde dehydrogenase; Validated; Region: PRK08300 36809001598 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 36809001599 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 36809001600 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 36809001601 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 36809001602 active site 36809001603 catalytic residues [active] 36809001604 metal binding site [ion binding]; metal-binding site 36809001605 DmpG-like communication domain; Region: DmpG_comm; pfam07836 36809001606 Mid-1-related chloride channel (MCLC); Region: MCLC; pfam05934 36809001607 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 36809001608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 36809001609 P-loop; other site 36809001610 Magnesium ion binding site [ion binding]; other site 36809001611 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 36809001612 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 36809001613 P-loop; other site 36809001614 Magnesium ion binding site [ion binding]; other site 36809001615 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 36809001616 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 36809001617 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 36809001618 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 36809001619 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 36809001620 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 36809001621 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 36809001622 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 36809001623 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 36809001624 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 36809001625 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 36809001626 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 36809001627 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 36809001628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809001629 Walker A motif; other site 36809001630 ATP binding site [chemical binding]; other site 36809001631 Walker B motif; other site 36809001632 arginine finger; other site 36809001633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809001634 Walker A motif; other site 36809001635 ATP binding site [chemical binding]; other site 36809001636 Walker B motif; other site 36809001637 arginine finger; other site 36809001638 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 36809001639 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 36809001640 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 36809001641 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 36809001642 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 36809001643 dimer interface [polypeptide binding]; other site 36809001644 putative functional site; other site 36809001645 putative MPT binding site; other site 36809001646 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 36809001647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809001648 active site 36809001649 motif I; other site 36809001650 motif II; other site 36809001651 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 36809001652 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 36809001653 short chain dehydrogenase; Region: adh_short; pfam00106 36809001654 putative NAD(P) binding site [chemical binding]; other site 36809001655 active site 36809001656 Cupin domain; Region: Cupin_2; pfam07883 36809001657 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 36809001658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809001659 ATP binding site [chemical binding]; other site 36809001660 putative Mg++ binding site [ion binding]; other site 36809001661 short chain dehydrogenase; Provisional; Region: PRK12937 36809001662 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 36809001663 putative NAD(P) binding site [chemical binding]; other site 36809001664 active site 36809001665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001667 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 36809001668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809001669 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 36809001670 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 36809001671 ring oligomerisation interface [polypeptide binding]; other site 36809001672 ATP/Mg binding site [chemical binding]; other site 36809001673 stacking interactions; other site 36809001674 hinge regions; other site 36809001675 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 36809001676 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 36809001677 MoxR-like ATPases [General function prediction only]; Region: COG0714 36809001678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809001679 Walker A motif; other site 36809001680 ATP binding site [chemical binding]; other site 36809001681 Walker B motif; other site 36809001682 arginine finger; other site 36809001683 Protein of unknown function DUF58; Region: DUF58; pfam01882 36809001684 von Willebrand factor type A domain; Region: VWA_2; pfam13519 36809001685 Tetratricopeptide repeat; Region: TPR_12; pfam13424 36809001686 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 36809001687 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 36809001688 FcoT-like thioesterase domain; Region: FcoT; pfam10862 36809001689 acyl-CoA synthetase; Validated; Region: PRK05857 36809001690 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 36809001691 acyl-activating enzyme (AAE) consensus motif; other site 36809001692 AMP binding site [chemical binding]; other site 36809001693 active site 36809001694 CoA binding site [chemical binding]; other site 36809001695 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809001696 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 36809001697 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809001698 acyl-activating enzyme (AAE) consensus motif; other site 36809001699 AMP binding site [chemical binding]; other site 36809001700 active site 36809001701 CoA binding site [chemical binding]; other site 36809001702 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809001703 thioester reductase domain; Region: Thioester-redct; TIGR01746 36809001704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809001705 NAD(P) binding site [chemical binding]; other site 36809001706 active site 36809001707 PE family; Region: PE; pfam00934 36809001708 Proteins of 100 residues with WXG; Region: WXG100; cl02005 36809001709 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 36809001710 metal-binding site [ion binding] 36809001711 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 36809001712 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 36809001713 PPE family; Region: PPE; pfam00823 36809001714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809001715 Domain of unknown function (DUF202); Region: DUF202; cl09954 36809001716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809001717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809001718 active site 36809001719 phosphorylation site [posttranslational modification] 36809001720 intermolecular recognition site; other site 36809001721 dimerization interface [polypeptide binding]; other site 36809001722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809001723 DNA binding site [nucleotide binding] 36809001724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809001725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809001726 dimerization interface [polypeptide binding]; other site 36809001727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809001728 dimer interface [polypeptide binding]; other site 36809001729 phosphorylation site [posttranslational modification] 36809001730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809001731 ATP binding site [chemical binding]; other site 36809001732 Mg2+ binding site [ion binding]; other site 36809001733 G-X-G motif; other site 36809001734 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 36809001735 nucleotide binding site/active site [active] 36809001736 HIT family signature motif; other site 36809001737 catalytic residue [active] 36809001738 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 36809001739 EamA-like transporter family; Region: EamA; pfam00892 36809001740 EamA-like transporter family; Region: EamA; pfam00892 36809001741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809001742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809001743 putative DNA binding site [nucleotide binding]; other site 36809001744 dimerization interface [polypeptide binding]; other site 36809001745 putative Zn2+ binding site [ion binding]; other site 36809001746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 36809001747 dimerization interface [polypeptide binding]; other site 36809001748 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809001749 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809001750 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 36809001751 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 36809001752 active site 36809001753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001755 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 36809001756 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 36809001757 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 36809001758 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 36809001759 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809001760 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 36809001761 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809001762 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 36809001763 S-formylglutathione hydrolase; Region: PLN02442 36809001764 aspartate aminotransferase; Provisional; Region: PRK05764 36809001765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809001766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809001767 homodimer interface [polypeptide binding]; other site 36809001768 catalytic residue [active] 36809001769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 36809001770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001771 adenylosuccinate lyase; Region: purB; TIGR00928 36809001772 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 36809001773 tetramer interface [polypeptide binding]; other site 36809001774 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 36809001775 ATP binding site [chemical binding]; other site 36809001776 active site 36809001777 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 36809001778 substrate binding site [chemical binding]; other site 36809001779 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 36809001780 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 36809001781 short chain dehydrogenase; Provisional; Region: PRK06940 36809001782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 36809001783 NAD(P) binding site [chemical binding]; other site 36809001784 active site 36809001785 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 36809001786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809001787 putative substrate translocation pore; other site 36809001788 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 36809001789 catalytic residues [active] 36809001790 dimer interface [polypeptide binding]; other site 36809001791 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 36809001792 putative active site [active] 36809001793 putative Zn binding site [ion binding]; other site 36809001794 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 36809001795 Predicted oxidoreductase [General function prediction only]; Region: COG3573 36809001796 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 36809001797 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 36809001798 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 36809001799 putative active site [active] 36809001800 catalytic triad [active] 36809001801 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 36809001802 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 36809001803 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 36809001804 active site 36809001805 metal binding site [ion binding]; metal-binding site 36809001806 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809001807 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 36809001808 DoxX-like family; Region: DoxX_2; pfam13564 36809001809 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 36809001810 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 36809001811 dimerization interface [polypeptide binding]; other site 36809001812 ATP binding site [chemical binding]; other site 36809001813 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 36809001814 dimerization interface [polypeptide binding]; other site 36809001815 ATP binding site [chemical binding]; other site 36809001816 Predicted membrane protein [Function unknown]; Region: COG4425 36809001817 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 36809001818 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 36809001819 CAAX protease self-immunity; Region: Abi; pfam02517 36809001820 amidophosphoribosyltransferase; Provisional; Region: PRK07847 36809001821 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 36809001822 active site 36809001823 tetramer interface [polypeptide binding]; other site 36809001824 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809001825 active site 36809001826 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 36809001827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 36809001828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809001829 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809001830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809001831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809001832 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 36809001833 NAD(P) binding site [chemical binding]; other site 36809001834 active site 36809001835 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 36809001836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809001837 NAD(P) binding site [chemical binding]; other site 36809001838 active site 36809001839 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 36809001840 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 36809001841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 36809001842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809001843 dimer interface [polypeptide binding]; other site 36809001844 conserved gate region; other site 36809001845 putative PBP binding loops; other site 36809001846 ABC-ATPase subunit interface; other site 36809001847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 36809001848 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 36809001849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809001850 dimer interface [polypeptide binding]; other site 36809001851 conserved gate region; other site 36809001852 putative PBP binding loops; other site 36809001853 ABC-ATPase subunit interface; other site 36809001854 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 36809001855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 36809001856 Walker A/P-loop; other site 36809001857 ATP binding site [chemical binding]; other site 36809001858 Q-loop/lid; other site 36809001859 ABC transporter signature motif; other site 36809001860 Walker B; other site 36809001861 D-loop; other site 36809001862 H-loop/switch region; other site 36809001863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 36809001864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 36809001865 Walker A/P-loop; other site 36809001866 ATP binding site [chemical binding]; other site 36809001867 Q-loop/lid; other site 36809001868 ABC transporter signature motif; other site 36809001869 Walker B; other site 36809001870 D-loop; other site 36809001871 H-loop/switch region; other site 36809001872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 36809001873 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809001874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809001875 amidase; Provisional; Region: PRK07869 36809001876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 36809001877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001878 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 36809001879 iron-sulfur cluster [ion binding]; other site 36809001880 [2Fe-2S] cluster binding site [ion binding]; other site 36809001881 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809001882 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 36809001883 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 36809001884 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 36809001885 intersubunit interface [polypeptide binding]; other site 36809001886 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 36809001887 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 36809001888 dimerization interface [polypeptide binding]; other site 36809001889 putative ATP binding site [chemical binding]; other site 36809001890 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 36809001891 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 36809001892 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 36809001893 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 36809001894 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 36809001895 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 36809001896 homodimer interface [polypeptide binding]; other site 36809001897 substrate-cofactor binding pocket; other site 36809001898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809001899 catalytic residue [active] 36809001900 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 36809001901 heme-binding site [chemical binding]; other site 36809001902 MspA; Region: MspA; pfam09203 36809001903 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809001904 active site 36809001905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809001906 Helix-turn-helix domain; Region: HTH_18; pfam12833 36809001907 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 36809001908 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 36809001909 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 36809001910 active site residue [active] 36809001911 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 36809001912 active site residue [active] 36809001913 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 36809001914 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 36809001915 catalytic residues [active] 36809001916 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 36809001917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809001918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809001919 DNA binding site [nucleotide binding] 36809001920 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 36809001921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809001922 Coenzyme A binding pocket [chemical binding]; other site 36809001923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809001924 Coenzyme A binding pocket [chemical binding]; other site 36809001925 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 36809001926 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 36809001927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809001928 dimer interface [polypeptide binding]; other site 36809001929 conserved gate region; other site 36809001930 putative PBP binding loops; other site 36809001931 ABC-ATPase subunit interface; other site 36809001932 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 36809001933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809001934 dimer interface [polypeptide binding]; other site 36809001935 conserved gate region; other site 36809001936 putative PBP binding loops; other site 36809001937 ABC-ATPase subunit interface; other site 36809001938 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 36809001939 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 36809001940 Walker A/P-loop; other site 36809001941 ATP binding site [chemical binding]; other site 36809001942 Q-loop/lid; other site 36809001943 ABC transporter signature motif; other site 36809001944 Walker B; other site 36809001945 D-loop; other site 36809001946 H-loop/switch region; other site 36809001947 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809001948 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 36809001949 putative NAD(P) binding site [chemical binding]; other site 36809001950 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 36809001951 PhoU domain; Region: PhoU; pfam01895 36809001952 PhoU domain; Region: PhoU; pfam01895 36809001953 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 36809001954 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 36809001955 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 36809001956 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 36809001957 FMN binding site [chemical binding]; other site 36809001958 active site 36809001959 catalytic residues [active] 36809001960 substrate binding site [chemical binding]; other site 36809001961 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 36809001962 homodimer interface [polypeptide binding]; other site 36809001963 putative substrate binding pocket [chemical binding]; other site 36809001964 diiron center [ion binding]; other site 36809001965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809001966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809001967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 36809001968 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 36809001969 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 36809001970 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 36809001971 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 36809001972 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 36809001973 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 36809001974 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 36809001975 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 36809001976 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809001977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809001978 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 36809001979 NAD(P) binding site [chemical binding]; other site 36809001980 active site 36809001981 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 36809001982 EamA-like transporter family; Region: EamA; pfam00892 36809001983 EamA-like transporter family; Region: EamA; pfam00892 36809001984 Cupin; Region: Cupin_6; pfam12852 36809001985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809001986 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 36809001987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809001988 Probable pheophorbidase; Region: PLN02965; cl17657 36809001989 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809001990 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809001991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809001992 non-specific DNA binding site [nucleotide binding]; other site 36809001993 salt bridge; other site 36809001994 sequence-specific DNA binding site [nucleotide binding]; other site 36809001995 Cupin domain; Region: Cupin_2; cl17218 36809001996 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 36809001997 putative deacylase active site [active] 36809001998 benzoate transport; Region: 2A0115; TIGR00895 36809001999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809002000 putative substrate translocation pore; other site 36809002001 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 36809002002 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 36809002003 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 36809002004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 36809002005 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 36809002006 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 36809002007 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809002008 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 36809002009 PPE family; Region: PPE; pfam00823 36809002010 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 36809002011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809002012 DNA-binding site [nucleotide binding]; DNA binding site 36809002013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809002014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809002015 homodimer interface [polypeptide binding]; other site 36809002016 catalytic residue [active] 36809002017 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 36809002018 EamA-like transporter family; Region: EamA; pfam00892 36809002019 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809002020 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 36809002021 Domain of unknown function (DUF4423); Region: DUF4423; cl19903 36809002022 Bacterial transcriptional regulator; Region: IclR; pfam01614 36809002023 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809002024 Bacterial transcriptional regulator; Region: IclR; pfam01614 36809002025 Amino acid permease; Region: AA_permease_2; pfam13520 36809002026 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 36809002027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002029 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 36809002030 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 36809002031 tetrameric interface [polypeptide binding]; other site 36809002032 NAD binding site [chemical binding]; other site 36809002033 catalytic residues [active] 36809002034 substrate binding site [chemical binding]; other site 36809002035 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809002036 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 36809002037 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 36809002038 putative active site [active] 36809002039 catalytic triad [active] 36809002040 putative dimer interface [polypeptide binding]; other site 36809002041 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202 36809002042 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809002043 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809002044 inhibitor-cofactor binding pocket; inhibition site 36809002045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809002046 catalytic residue [active] 36809002047 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809002048 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809002049 active site 36809002050 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 36809002051 NAD(P) binding site [chemical binding]; other site 36809002052 catalytic residues [active] 36809002053 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 36809002054 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 36809002055 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 36809002056 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809002057 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809002058 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809002059 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 36809002060 classical (c) SDRs; Region: SDR_c; cd05233 36809002061 NAD(P) binding site [chemical binding]; other site 36809002062 active site 36809002063 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 36809002064 phosphate binding site [ion binding]; other site 36809002065 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 36809002066 FMN binding site [chemical binding]; other site 36809002067 active site 36809002068 substrate binding site [chemical binding]; other site 36809002069 catalytic residue [active] 36809002070 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 36809002071 putative hydrophobic ligand binding site [chemical binding]; other site 36809002072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002074 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 36809002075 classical (c) SDRs; Region: SDR_c; cd05233 36809002076 NAD(P) binding site [chemical binding]; other site 36809002077 active site 36809002078 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 36809002079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002080 substrate binding site [chemical binding]; other site 36809002081 oxyanion hole (OAH) forming residues; other site 36809002082 trimer interface [polypeptide binding]; other site 36809002083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002085 enoyl-CoA hydratase; Provisional; Region: PRK07799 36809002086 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002087 substrate binding site [chemical binding]; other site 36809002088 oxyanion hole (OAH) forming residues; other site 36809002089 trimer interface [polypeptide binding]; other site 36809002090 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 36809002091 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809002092 active site 36809002093 lipid-transfer protein; Provisional; Region: PRK07937 36809002094 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 36809002095 active site 36809002096 DUF35 OB-fold domain; Region: DUF35; pfam01796 36809002097 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 36809002098 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 36809002099 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809002100 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809002101 aminotransferase; Validated; Region: PRK07777 36809002102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809002103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809002104 homodimer interface [polypeptide binding]; other site 36809002105 catalytic residue [active] 36809002106 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 36809002107 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809002108 dimer interface [polypeptide binding]; other site 36809002109 active site 36809002110 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 36809002111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002112 substrate binding site [chemical binding]; other site 36809002113 oxyanion hole (OAH) forming residues; other site 36809002114 trimer interface [polypeptide binding]; other site 36809002115 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 36809002116 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 36809002117 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 36809002118 Condensation domain; Region: Condensation; cl19241 36809002119 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809002120 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 36809002121 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 36809002122 MMPL family; Region: MMPL; pfam03176 36809002123 MMPL family; Region: MMPL; pfam03176 36809002124 tetracycline repressor protein TetR; Provisional; Region: PRK13756 36809002125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002126 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 36809002127 hypothetical protein; Provisional; Region: PRK06834 36809002128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002129 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 36809002130 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809002131 hydrophobic ligand binding site; other site 36809002132 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 36809002133 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 36809002134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809002135 ATP binding site [chemical binding]; other site 36809002136 putative Mg++ binding site [ion binding]; other site 36809002137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809002138 nucleotide binding region [chemical binding]; other site 36809002139 ATP-binding site [chemical binding]; other site 36809002140 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 36809002141 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 36809002142 WYL domain; Region: WYL; cl14852 36809002143 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 36809002144 trimer interface [polypeptide binding]; other site 36809002145 dimer interface [polypeptide binding]; other site 36809002146 putative active site [active] 36809002147 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 36809002148 MPT binding site; other site 36809002149 trimer interface [polypeptide binding]; other site 36809002150 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 36809002151 MoaE homodimer interface [polypeptide binding]; other site 36809002152 MoaD interaction [polypeptide binding]; other site 36809002153 active site residues [active] 36809002154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809002155 S-adenosylmethionine binding site [chemical binding]; other site 36809002156 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809002157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809002158 S-adenosylmethionine binding site [chemical binding]; other site 36809002159 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 36809002160 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 36809002161 MoaE interaction surface [polypeptide binding]; other site 36809002162 MoeB interaction surface [polypeptide binding]; other site 36809002163 thiocarboxylated glycine; other site 36809002164 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 36809002165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809002166 FeS/SAM binding site; other site 36809002167 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 36809002168 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 36809002169 DNA-binding site [nucleotide binding]; DNA binding site 36809002170 RNA-binding motif; other site 36809002171 A new structural DNA glycosylase; Region: AlkD_like; cd06561 36809002172 active site 36809002173 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 36809002174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809002175 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 36809002176 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 36809002177 hydrophobic ligand binding site; other site 36809002178 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 36809002179 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002180 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809002181 putative DNA binding site [nucleotide binding]; other site 36809002182 putative Zn2+ binding site [ion binding]; other site 36809002183 H+ Antiporter protein; Region: 2A0121; TIGR00900 36809002184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809002185 putative substrate translocation pore; other site 36809002186 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 36809002187 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 36809002188 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 36809002189 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 36809002190 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 36809002191 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 36809002192 Domain of unknown function (DUF202); Region: DUF202; cl09954 36809002193 fumarylacetoacetase; Region: PLN02856 36809002194 Fumarylacetoacetase N-terminal; Region: FAA_hydrolase_N; pfam09298 36809002195 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 36809002196 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 36809002197 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002198 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809002199 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809002200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809002201 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 36809002202 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 36809002203 dimer interface [polypeptide binding]; other site 36809002204 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 36809002205 active site 36809002206 Fe binding site [ion binding]; other site 36809002207 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 36809002208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809002210 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809002211 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 36809002212 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 36809002213 E3 interaction surface; other site 36809002214 lipoyl attachment site [posttranslational modification]; other site 36809002215 e3 binding domain; Region: E3_binding; pfam02817 36809002216 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 36809002217 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 36809002218 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 36809002219 alpha subunit interface [polypeptide binding]; other site 36809002220 TPP binding site [chemical binding]; other site 36809002221 heterodimer interface [polypeptide binding]; other site 36809002222 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 36809002223 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 36809002224 tetramer interface [polypeptide binding]; other site 36809002225 TPP-binding site [chemical binding]; other site 36809002226 heterodimer interface [polypeptide binding]; other site 36809002227 phosphorylation loop region [posttranslational modification] 36809002228 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809002229 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 36809002230 putative DNA binding site [nucleotide binding]; other site 36809002231 putative Zn2+ binding site [ion binding]; other site 36809002232 conserved hypothetical protein; Region: TIGR02118 36809002233 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 36809002234 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 36809002235 substrate binding site [chemical binding]; other site 36809002236 dimer interface [polypeptide binding]; other site 36809002237 NADP binding site [chemical binding]; other site 36809002238 catalytic residues [active] 36809002239 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809002240 active site 2 [active] 36809002241 active site 1 [active] 36809002242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002244 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 36809002245 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809002246 dimer interface [polypeptide binding]; other site 36809002247 active site 36809002248 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 36809002249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002250 substrate binding site [chemical binding]; other site 36809002251 oxyanion hole (OAH) forming residues; other site 36809002252 trimer interface [polypeptide binding]; other site 36809002253 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 36809002254 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 36809002255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 36809002256 enoyl-CoA hydratase; Provisional; Region: PRK08140 36809002257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002258 substrate binding site [chemical binding]; other site 36809002259 oxyanion hole (OAH) forming residues; other site 36809002260 trimer interface [polypeptide binding]; other site 36809002261 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 36809002262 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 36809002263 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 36809002264 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 36809002265 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 36809002266 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 36809002267 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 36809002268 FAD binding pocket [chemical binding]; other site 36809002269 FAD binding motif [chemical binding]; other site 36809002270 phosphate binding motif [ion binding]; other site 36809002271 beta-alpha-beta structure motif; other site 36809002272 NAD(p) ribose binding residues [chemical binding]; other site 36809002273 NAD binding pocket [chemical binding]; other site 36809002274 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 36809002275 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809002276 catalytic loop [active] 36809002277 iron binding site [ion binding]; other site 36809002278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809002279 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 36809002280 acyl-activating enzyme (AAE) consensus motif; other site 36809002281 AMP binding site [chemical binding]; other site 36809002282 active site 36809002283 CoA binding site [chemical binding]; other site 36809002284 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809002285 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 36809002286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002287 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809002288 Reductase C-terminal; Region: Reductase_C; pfam14759 36809002289 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809002290 catalytic loop [active] 36809002291 iron binding site [ion binding]; other site 36809002292 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 36809002293 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 36809002294 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u11; cd10942 36809002295 putative active site [active] 36809002296 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 36809002297 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809002298 Secretory lipase; Region: LIP; pfam03583 36809002299 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 36809002300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809002301 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 36809002302 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809002303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809002304 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809002305 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 36809002306 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002307 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809002308 dimerization interface [polypeptide binding]; other site 36809002309 putative Zn2+ binding site [ion binding]; other site 36809002310 putative DNA binding site [nucleotide binding]; other site 36809002311 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 36809002312 Ligand binding site; other site 36809002313 Ligand binding site; other site 36809002314 Ligand binding site; other site 36809002315 Putative Catalytic site; other site 36809002316 DXD motif; other site 36809002317 GtrA-like protein; Region: GtrA; pfam04138 36809002318 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 36809002319 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 36809002320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 36809002321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809002322 catalytic residue [active] 36809002323 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 36809002324 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 36809002325 4Fe-4S binding domain; Region: Fer4; pfam00037 36809002326 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 36809002327 ferredoxin-NADP+ reductase; Region: PLN02852 36809002328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002329 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 36809002330 putative dimer interface [polypeptide binding]; other site 36809002331 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 36809002332 citrate synthase 2; Provisional; Region: PRK12350 36809002333 oxalacetate binding site [chemical binding]; other site 36809002334 citrylCoA binding site [chemical binding]; other site 36809002335 coenzyme A binding site [chemical binding]; other site 36809002336 catalytic triad [active] 36809002337 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 36809002338 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 36809002339 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 36809002340 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 36809002341 acyl-CoA synthetase; Validated; Region: PRK05850 36809002342 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809002343 acyl-activating enzyme (AAE) consensus motif; other site 36809002344 active site 36809002345 PE-PPE domain; Region: PE-PPE; pfam08237 36809002346 Transport protein; Region: actII; TIGR00833 36809002347 MMPL family; Region: MMPL; pfam03176 36809002348 MMPL family; Region: MMPL; pfam03176 36809002349 Condensation domain; Region: Condensation; cl19241 36809002350 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 36809002351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809002352 active site 36809002353 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809002354 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 36809002355 short chain dehydrogenase; Region: adh_short; pfam00106 36809002356 NADP binding site [chemical binding]; other site 36809002357 active site 36809002358 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 36809002359 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 36809002360 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809002361 active site 36809002362 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809002363 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 36809002364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809002365 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 36809002366 Enoylreductase; Region: PKS_ER; smart00829 36809002367 NAD(P) binding site [chemical binding]; other site 36809002368 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 36809002369 short chain dehydrogenase; Region: adh_short; pfam00106 36809002370 putative NADP binding site [chemical binding]; other site 36809002371 active site 36809002372 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 36809002373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809002374 H+ Antiporter protein; Region: 2A0121; TIGR00900 36809002375 putative substrate translocation pore; other site 36809002376 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 36809002377 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 36809002378 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 36809002379 conserved cys residue [active] 36809002380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809002381 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 36809002382 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 36809002383 conserved cys residue [active] 36809002384 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 36809002385 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 36809002386 dimer interface [polypeptide binding]; other site 36809002387 active site 36809002388 citrylCoA binding site [chemical binding]; other site 36809002389 NADH binding [chemical binding]; other site 36809002390 cationic pore residues; other site 36809002391 oxalacetate/citrate binding site [chemical binding]; other site 36809002392 coenzyme A binding site [chemical binding]; other site 36809002393 catalytic triad [active] 36809002394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809002395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809002396 putative substrate translocation pore; other site 36809002397 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809002399 putative DNA binding site [nucleotide binding]; other site 36809002400 dimerization interface [polypeptide binding]; other site 36809002401 putative Zn2+ binding site [ion binding]; other site 36809002402 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809002403 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 36809002404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809002405 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809002406 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809002407 inhibitor-cofactor binding pocket; inhibition site 36809002408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809002409 catalytic residue [active] 36809002410 Amino acid permease; Region: AA_permease_2; pfam13520 36809002411 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809002412 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 36809002413 Phosphotransferase enzyme family; Region: APH; pfam01636 36809002414 active site 36809002415 ATP binding site [chemical binding]; other site 36809002416 short chain dehydrogenase; Provisional; Region: PRK12829 36809002417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809002418 NAD(P) binding site [chemical binding]; other site 36809002419 active site 36809002420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809002421 DNA-binding site [nucleotide binding]; DNA binding site 36809002422 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 36809002423 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 36809002424 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 36809002425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809002426 HAMP domain; Region: HAMP; pfam00672 36809002427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809002428 dimer interface [polypeptide binding]; other site 36809002429 phosphorylation site [posttranslational modification] 36809002430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809002431 ATP binding site [chemical binding]; other site 36809002432 Mg2+ binding site [ion binding]; other site 36809002433 G-X-G motif; other site 36809002434 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809002435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809002436 active site 36809002437 phosphorylation site [posttranslational modification] 36809002438 intermolecular recognition site; other site 36809002439 dimerization interface [polypeptide binding]; other site 36809002440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809002441 DNA binding site [nucleotide binding] 36809002442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002443 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809002444 enoyl-CoA hydratase; Provisional; Region: PRK07854 36809002445 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002446 substrate binding site [chemical binding]; other site 36809002447 oxyanion hole (OAH) forming residues; other site 36809002448 trimer interface [polypeptide binding]; other site 36809002449 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 36809002450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809002451 S-adenosylmethionine binding site [chemical binding]; other site 36809002452 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 36809002453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 36809002454 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 36809002455 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 36809002456 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 36809002457 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 36809002458 Secretory lipase; Region: LIP; pfam03583 36809002459 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 36809002460 hydrophobic ligand binding site; other site 36809002461 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809002462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002463 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809002464 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 36809002465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809002466 putative substrate translocation pore; other site 36809002467 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809002468 CoenzymeA binding site [chemical binding]; other site 36809002469 subunit interaction site [polypeptide binding]; other site 36809002470 PHB binding site; other site 36809002471 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 36809002472 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 36809002473 NAD(P) binding site [chemical binding]; other site 36809002474 catalytic residues [active] 36809002475 Protein of unknown function (DUF779); Region: DUF779; pfam05610 36809002476 ribonuclease E; Reviewed; Region: rne; PRK10811 36809002477 hypothetical protein; Validated; Region: PRK02101 36809002478 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 36809002479 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 36809002480 DNA polymerase IV; Validated; Region: PRK03858 36809002481 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 36809002482 active site 36809002483 DNA binding site [nucleotide binding] 36809002484 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 36809002485 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002486 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809002487 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 36809002488 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002489 substrate binding site [chemical binding]; other site 36809002490 oxyanion hole (OAH) forming residues; other site 36809002491 trimer interface [polypeptide binding]; other site 36809002492 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 36809002493 active site 36809002494 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 36809002495 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 36809002496 NAD(P) binding site [chemical binding]; other site 36809002497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002499 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809002500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809002501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809002502 dimerization interface [polypeptide binding]; other site 36809002503 putative DNA binding site [nucleotide binding]; other site 36809002504 putative Zn2+ binding site [ion binding]; other site 36809002505 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 36809002506 putative hydrophobic ligand binding site [chemical binding]; other site 36809002507 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 36809002508 MMPL family; Region: MMPL; pfam03176 36809002509 MMPL family; Region: MMPL; pfam03176 36809002510 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809002511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002513 Domain of unknown function (DUF222); Region: DUF222; pfam02720 36809002514 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809002515 active site 36809002516 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 36809002517 catalytic residues [active] 36809002518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809002519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809002520 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 36809002521 dimerization interface [polypeptide binding]; other site 36809002522 substrate binding pocket [chemical binding]; other site 36809002523 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 36809002524 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809002525 putative NAD(P) binding site [chemical binding]; other site 36809002526 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 36809002527 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 36809002528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809002529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809002530 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 36809002531 dimerization interface [polypeptide binding]; other site 36809002532 formate dehydrogenase; Provisional; Region: PRK07574 36809002533 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 36809002534 dimerization interface [polypeptide binding]; other site 36809002535 ligand binding site [chemical binding]; other site 36809002536 NAD binding site [chemical binding]; other site 36809002537 catalytic site [active] 36809002538 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 36809002539 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809002540 dimer interface [polypeptide binding]; other site 36809002541 active site 36809002542 Mannan-binding protein; Region: MVL; pfam12151 36809002543 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 36809002544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 36809002545 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809002546 mce related protein; Region: MCE; pfam02470 36809002547 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809002548 mce related protein; Region: MCE; pfam02470 36809002549 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 36809002550 mce related protein; Region: MCE; pfam02470 36809002551 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809002552 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809002553 mce related protein; Region: MCE; pfam02470 36809002554 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809002555 mce related protein; Region: MCE; pfam02470 36809002556 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 36809002557 mce related protein; Region: MCE; pfam02470 36809002558 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 36809002559 Permease; Region: Permease; pfam02405 36809002560 Permease; Region: Permease; pfam02405 36809002561 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 36809002562 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 36809002563 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 36809002564 putative ADP-binding pocket [chemical binding]; other site 36809002565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809002566 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 36809002567 putative active site [active] 36809002568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 36809002569 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 36809002570 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 36809002571 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 36809002572 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 36809002573 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809002574 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 36809002575 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809002576 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 36809002577 Bacterial sugar transferase; Region: Bac_transf; pfam02397 36809002578 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002579 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809002580 Predicted esterase [General function prediction only]; Region: COG0627 36809002581 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809002582 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809002583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002585 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 36809002586 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 36809002587 Immunity protein 38; Region: Imm38; pfam15599 36809002588 cyanate hydratase; Validated; Region: PRK02866 36809002589 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 36809002590 oligomer interface [polypeptide binding]; other site 36809002591 active site 36809002592 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002593 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809002594 putative Zn2+ binding site [ion binding]; other site 36809002595 putative DNA binding site [nucleotide binding]; other site 36809002596 manganese transport protein MntH; Reviewed; Region: PRK00701 36809002597 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 36809002598 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 36809002599 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 36809002600 putative DNA binding site [nucleotide binding]; other site 36809002601 putative homodimer interface [polypeptide binding]; other site 36809002602 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 36809002603 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 36809002604 nucleotide binding site [chemical binding]; other site 36809002605 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 36809002606 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 36809002607 active site 36809002608 DNA binding site [nucleotide binding] 36809002609 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 36809002610 DNA binding site [nucleotide binding] 36809002611 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 36809002612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002614 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 36809002615 active site 36809002616 SAM binding site [chemical binding]; other site 36809002617 homodimer interface [polypeptide binding]; other site 36809002618 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 36809002619 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 36809002620 putative DNA binding site [nucleotide binding]; other site 36809002621 catalytic residue [active] 36809002622 putative H2TH interface [polypeptide binding]; other site 36809002623 putative catalytic residues [active] 36809002624 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 36809002625 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 36809002626 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809002627 short chain dehydrogenase; Provisional; Region: PRK08251 36809002628 NAD(P) binding site [chemical binding]; other site 36809002629 active site 36809002630 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 36809002631 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 36809002632 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 36809002633 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 36809002634 D-pathway; other site 36809002635 Low-spin heme binding site [chemical binding]; other site 36809002636 Putative water exit pathway; other site 36809002637 Binuclear center (active site) [active] 36809002638 K-pathway; other site 36809002639 Putative proton exit pathway; other site 36809002640 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 36809002641 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 36809002642 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 36809002643 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809002644 active site 36809002645 metal binding site [ion binding]; metal-binding site 36809002646 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 36809002647 CGNR zinc finger; Region: zf-CGNR; pfam11706 36809002648 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 36809002649 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 36809002650 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 36809002651 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 36809002652 inhibitor site; inhibition site 36809002653 active site 36809002654 dimer interface [polypeptide binding]; other site 36809002655 catalytic residue [active] 36809002656 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 36809002657 intersubunit interface [polypeptide binding]; other site 36809002658 active site 36809002659 Zn2+ binding site [ion binding]; other site 36809002660 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809002661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809002662 non-specific DNA binding site [nucleotide binding]; other site 36809002663 salt bridge; other site 36809002664 sequence-specific DNA binding site [nucleotide binding]; other site 36809002665 Cupin domain; Region: Cupin_2; pfam07883 36809002666 methionine sulfoxide reductase B; Provisional; Region: PRK00222 36809002667 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 36809002668 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 36809002669 active site 36809002670 dimer interface [polypeptide binding]; other site 36809002671 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 36809002672 dimer interface [polypeptide binding]; other site 36809002673 active site 36809002674 Chorismate mutase type II; Region: CM_2; cl00693 36809002675 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 36809002676 Part of AAA domain; Region: AAA_19; pfam13245 36809002677 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 36809002678 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 36809002679 Peptidase family M23; Region: Peptidase_M23; pfam01551 36809002680 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 36809002681 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 36809002682 CoA-ligase; Region: Ligase_CoA; pfam00549 36809002683 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 36809002684 CoA binding domain; Region: CoA_binding; smart00881 36809002685 CoA-ligase; Region: Ligase_CoA; pfam00549 36809002686 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 36809002687 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 36809002688 active site 36809002689 dimer interface [polypeptide binding]; other site 36809002690 non-prolyl cis peptide bond; other site 36809002691 insertion regions; other site 36809002692 EBNA-3B; Provisional; Region: PHA03378 36809002693 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 36809002694 active site 36809002695 substrate binding site [chemical binding]; other site 36809002696 cosubstrate binding site; other site 36809002697 catalytic site [active] 36809002698 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 36809002699 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 36809002700 purine monophosphate binding site [chemical binding]; other site 36809002701 dimer interface [polypeptide binding]; other site 36809002702 putative catalytic residues [active] 36809002703 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 36809002704 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 36809002705 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 36809002706 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 36809002707 Cupin domain; Region: Cupin_2; cl17218 36809002708 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 36809002709 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 36809002710 enoyl-CoA hydratase; Provisional; Region: PRK07827 36809002711 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002712 substrate binding site [chemical binding]; other site 36809002713 oxyanion hole (OAH) forming residues; other site 36809002714 trimer interface [polypeptide binding]; other site 36809002715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809002716 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809002717 active site 36809002718 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 36809002719 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 36809002720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809002721 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 36809002722 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 36809002723 carboxyltransferase (CT) interaction site; other site 36809002724 biotinylation site [posttranslational modification]; other site 36809002725 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 36809002726 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809002727 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809002728 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809002729 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809002730 active site 36809002731 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 36809002732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809002733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809002734 active site 36809002735 phosphorylation site [posttranslational modification] 36809002736 intermolecular recognition site; other site 36809002737 dimerization interface [polypeptide binding]; other site 36809002738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809002739 DNA binding site [nucleotide binding] 36809002740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809002741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809002742 dimerization interface [polypeptide binding]; other site 36809002743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809002744 dimer interface [polypeptide binding]; other site 36809002745 phosphorylation site [posttranslational modification] 36809002746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809002747 ATP binding site [chemical binding]; other site 36809002748 Mg2+ binding site [ion binding]; other site 36809002749 G-X-G motif; other site 36809002750 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 36809002751 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 36809002752 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 36809002753 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 36809002754 MPT binding site; other site 36809002755 MspA; Region: MspA; pfam09203 36809002756 MspA; Region: MspA; pfam09203 36809002757 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 36809002758 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 36809002759 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 36809002760 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 36809002761 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 36809002762 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 36809002763 active site 36809002764 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 36809002765 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 36809002766 dimer interface [polypeptide binding]; other site 36809002767 putative functional site; other site 36809002768 putative MPT binding site; other site 36809002769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809002770 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 36809002771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 36809002772 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 36809002773 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 36809002774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809002775 catalytic residue [active] 36809002776 DNA-sulfur modification-associated; Region: DndB; cl17621 36809002777 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 36809002778 Active Sites [active] 36809002779 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 36809002780 AAA domain; Region: AAA_23; pfam13476 36809002781 Walker A/P-loop; other site 36809002782 ATP binding site [chemical binding]; other site 36809002783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809002784 Q-loop/lid; other site 36809002785 ABC transporter signature motif; other site 36809002786 Walker B; other site 36809002787 D-loop; other site 36809002788 H-loop/switch region; other site 36809002789 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 36809002790 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 36809002791 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 36809002792 active site 36809002793 GIY-YIG motif/motif A; other site 36809002794 catalytic site [active] 36809002795 Protein of unknown function DUF262; Region: DUF262; pfam03235 36809002796 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 36809002797 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 36809002798 Cupin domain; Region: Cupin_2; cl17218 36809002799 Helix-turn-helix domain; Region: HTH_18; pfam12833 36809002800 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 36809002801 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 36809002802 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 36809002803 NAD(P) binding site [chemical binding]; other site 36809002804 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809002805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809002806 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809002807 Predicted metal-dependent hydrolase; Region: Metal_hydrol; cl19844 36809002808 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 36809002809 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 36809002810 arginine deiminase; Provisional; Region: PRK01388 36809002811 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 36809002812 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 36809002813 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 36809002814 putative SAM binding site [chemical binding]; other site 36809002815 putative homodimer interface [polypeptide binding]; other site 36809002816 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 36809002817 chorismate binding enzyme; Region: Chorismate_bind; cl10555 36809002818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809002819 Coenzyme A binding pocket [chemical binding]; other site 36809002820 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 36809002821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809002822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809002823 DNA binding residues [nucleotide binding] 36809002824 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809002825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 36809002826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809002827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809002828 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 36809002829 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 36809002830 active site 36809002831 HIGH motif; other site 36809002832 KMSKS motif; other site 36809002833 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 36809002834 tRNA binding surface [nucleotide binding]; other site 36809002835 anticodon binding site; other site 36809002836 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 36809002837 active site 36809002838 Domain of unknown function (DUF348); Region: DUF348; pfam03990 36809002839 Domain of unknown function (DUF348); Region: DUF348; pfam03990 36809002840 Domain of unknown function (DUF348); Region: DUF348; pfam03990 36809002841 G5 domain; Region: G5; pfam07501 36809002842 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 36809002843 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 36809002844 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 36809002845 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809002846 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 36809002847 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 36809002848 active site 36809002849 ATP binding site [chemical binding]; other site 36809002850 substrate binding site [chemical binding]; other site 36809002851 activation loop (A-loop); other site 36809002852 Transport protein; Region: actII; TIGR00833 36809002853 MMPL family; Region: MMPL; pfam03176 36809002854 MMPL family; Region: MMPL; pfam03176 36809002855 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809002856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002858 Transport protein; Region: actII; TIGR00833 36809002859 MMPL family; Region: MMPL; pfam03176 36809002860 MMPL family; Region: MMPL; cl14618 36809002861 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809002863 putative DNA binding site [nucleotide binding]; other site 36809002864 putative Zn2+ binding site [ion binding]; other site 36809002865 putative acetyltransferase; Provisional; Region: PRK03624 36809002866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809002867 Coenzyme A binding pocket [chemical binding]; other site 36809002868 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 36809002869 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 36809002870 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 36809002871 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 36809002872 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809002873 acyl-activating enzyme (AAE) consensus motif; other site 36809002874 AMP binding site [chemical binding]; other site 36809002875 active site 36809002876 CoA binding site [chemical binding]; other site 36809002877 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 36809002878 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 36809002879 dimer interface [polypeptide binding]; other site 36809002880 active site 36809002881 CoA binding pocket [chemical binding]; other site 36809002882 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 36809002883 putative active site [active] 36809002884 catalytic residue [active] 36809002885 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 36809002886 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 36809002887 5S rRNA interface [nucleotide binding]; other site 36809002888 CTC domain interface [polypeptide binding]; other site 36809002889 L16 interface [polypeptide binding]; other site 36809002890 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 36809002891 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 36809002892 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 36809002893 putative NAD(P) binding site [chemical binding]; other site 36809002894 active site 36809002895 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 36809002896 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 36809002897 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 36809002898 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809002899 active site 36809002900 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 36809002901 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 36809002902 Substrate binding site; other site 36809002903 Mg++ binding site; other site 36809002904 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 36809002905 active site 36809002906 substrate binding site [chemical binding]; other site 36809002907 CoA binding site [chemical binding]; other site 36809002908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809002909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809002910 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 36809002911 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 36809002912 diaminopimelate decarboxylase; Region: lysA; TIGR01048 36809002913 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 36809002914 active site 36809002915 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 36809002916 substrate binding site [chemical binding]; other site 36809002917 catalytic residues [active] 36809002918 dimer interface [polypeptide binding]; other site 36809002919 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 36809002920 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 36809002921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809002922 ATP binding site [chemical binding]; other site 36809002923 putative Mg++ binding site [ion binding]; other site 36809002924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809002925 nucleotide binding region [chemical binding]; other site 36809002926 ATP-binding site [chemical binding]; other site 36809002927 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 36809002928 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 36809002929 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 36809002930 homodimer interface [polypeptide binding]; other site 36809002931 metal binding site [ion binding]; metal-binding site 36809002932 Iron permease FTR1 family; Region: FTR1; cl00475 36809002933 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 36809002934 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 36809002935 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 36809002936 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 36809002937 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 36809002938 Imelysin; Region: Peptidase_M75; pfam09375 36809002939 Iron permease FTR1 family; Region: FTR1; cl00475 36809002940 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 36809002941 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 36809002942 N-acetyl-D-glucosamine binding site [chemical binding]; other site 36809002943 enolase; Provisional; Region: eno; PRK00077 36809002944 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 36809002945 dimer interface [polypeptide binding]; other site 36809002946 metal binding site [ion binding]; metal-binding site 36809002947 substrate binding pocket [chemical binding]; other site 36809002948 Septum formation initiator; Region: DivIC; pfam04977 36809002949 Uncharacterized conserved protein [Function unknown]; Region: COG1507 36809002950 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 36809002951 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 36809002952 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809002953 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809002954 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 36809002955 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 36809002956 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809002957 acyl-activating enzyme (AAE) consensus motif; other site 36809002958 active site 36809002959 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 36809002960 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 36809002961 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 36809002962 LGFP repeat; Region: LGFP; pfam08310 36809002963 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 36809002964 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 36809002965 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 36809002966 active site residue [active] 36809002967 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809002968 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809002969 enoyl-CoA hydratase; Provisional; Region: PRK05862 36809002970 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002971 substrate binding site [chemical binding]; other site 36809002972 oxyanion hole (OAH) forming residues; other site 36809002973 trimer interface [polypeptide binding]; other site 36809002974 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 36809002975 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 36809002976 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 36809002977 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 36809002978 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809002979 substrate binding site [chemical binding]; other site 36809002980 oxyanion hole (OAH) forming residues; other site 36809002981 trimer interface [polypeptide binding]; other site 36809002982 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 36809002983 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809002984 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 36809002985 substrate binding pocket [chemical binding]; other site 36809002986 FAD binding site [chemical binding]; other site 36809002987 catalytic base [active] 36809002988 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 36809002989 tetrameric interface [polypeptide binding]; other site 36809002990 NAD binding site [chemical binding]; other site 36809002991 catalytic residues [active] 36809002992 Predicted membrane protein [Function unknown]; Region: COG4760 36809002993 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 36809002994 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 36809002995 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809002996 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 36809002997 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809002998 dimer interface [polypeptide binding]; other site 36809002999 active site 36809003000 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 36809003001 active site 36809003002 catalytic triad [active] 36809003003 oxyanion hole [active] 36809003004 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809003005 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809003006 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 36809003007 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 36809003008 dimer interface [polypeptide binding]; other site 36809003009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003010 catalytic residue [active] 36809003011 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 36809003012 RDD family; Region: RDD; pfam06271 36809003013 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 36809003014 homodimer interface [polypeptide binding]; other site 36809003015 substrate-cofactor binding pocket; other site 36809003016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003017 catalytic residue [active] 36809003018 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 36809003019 threonine dehydratase; Provisional; Region: PRK08198 36809003020 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 36809003021 tetramer interface [polypeptide binding]; other site 36809003022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003023 catalytic residue [active] 36809003024 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 36809003025 putative active site [active] 36809003026 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 36809003027 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 36809003028 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 36809003029 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 36809003030 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 36809003031 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 36809003032 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 36809003033 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 36809003034 catalytic residues [active] 36809003035 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 36809003036 Haemolysin-III related; Region: HlyIII; cl03831 36809003037 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 36809003038 active site 36809003039 dimer interface [polypeptide binding]; other site 36809003040 classical (c) SDRs; Region: SDR_c; cd05233 36809003041 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 36809003042 NAD(P) binding site [chemical binding]; other site 36809003043 active site 36809003044 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809003045 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 36809003046 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809003047 short chain dehydrogenase; Provisional; Region: PRK07775 36809003048 classical (c) SDRs; Region: SDR_c; cd05233 36809003049 NAD(P) binding site [chemical binding]; other site 36809003050 active site 36809003051 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809003052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003054 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 36809003055 NAD binding site [chemical binding]; other site 36809003056 catalytic residues [active] 36809003057 short chain dehydrogenase; Provisional; Region: PRK07774 36809003058 classical (c) SDRs; Region: SDR_c; cd05233 36809003059 NAD(P) binding site [chemical binding]; other site 36809003060 active site 36809003061 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 36809003062 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 36809003063 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 36809003064 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 36809003065 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 36809003066 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809003067 substrate binding pocket [chemical binding]; other site 36809003068 catalytic triad [active] 36809003069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809003070 dimer interface [polypeptide binding]; other site 36809003071 conserved gate region; other site 36809003072 putative PBP binding loops; other site 36809003073 ABC-ATPase subunit interface; other site 36809003074 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 36809003075 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 36809003076 Walker A/P-loop; other site 36809003077 ATP binding site [chemical binding]; other site 36809003078 Q-loop/lid; other site 36809003079 ABC transporter signature motif; other site 36809003080 Walker B; other site 36809003081 D-loop; other site 36809003082 H-loop/switch region; other site 36809003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809003084 dimer interface [polypeptide binding]; other site 36809003085 conserved gate region; other site 36809003086 putative PBP binding loops; other site 36809003087 ABC-ATPase subunit interface; other site 36809003088 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 36809003089 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 36809003090 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 36809003091 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 36809003092 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809003093 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 36809003094 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809003095 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 36809003096 ATP-binding site [chemical binding]; other site 36809003097 CoA-binding site [chemical binding]; other site 36809003098 Mg2+-binding site [ion binding]; other site 36809003099 Bacterial protein of unknown function (DUF885); Region: DUF885; cl19872 36809003100 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 36809003101 dimer interface [polypeptide binding]; other site 36809003102 active site 36809003103 glycine-pyridoxal phosphate binding site [chemical binding]; other site 36809003104 folate binding site [chemical binding]; other site 36809003105 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 36809003106 dinuclear metal binding motif [ion binding]; other site 36809003107 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 36809003108 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 36809003109 putative active site [active] 36809003110 PhoH-like protein; Region: PhoH; pfam02562 36809003111 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 36809003112 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 36809003113 NodB motif; other site 36809003114 active site 36809003115 catalytic site [active] 36809003116 metal binding site [ion binding]; metal-binding site 36809003117 CsbD-like; Region: CsbD; pfam05532 36809003118 Asp23 family; Region: Asp23; pfam03780 36809003119 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 36809003120 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809003121 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 36809003122 DNA binding residues [nucleotide binding] 36809003123 fumarate hydratase; Reviewed; Region: fumC; PRK00485 36809003124 Class II fumarases; Region: Fumarase_classII; cd01362 36809003125 active site 36809003126 tetramer interface [polypeptide binding]; other site 36809003127 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 36809003128 putative active site [active] 36809003129 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 36809003130 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 36809003131 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 36809003132 dimer interface [polypeptide binding]; other site 36809003133 active site 36809003134 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 36809003135 substrate binding site [chemical binding]; other site 36809003136 catalytic residue [active] 36809003137 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 36809003138 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 36809003139 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 36809003140 generic binding surface II; other site 36809003141 generic binding surface I; other site 36809003142 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl18948 36809003143 oxyanion hole (OAH) forming residues; other site 36809003144 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 36809003145 Fe-S cluster binding site [ion binding]; other site 36809003146 substrate binding site [chemical binding]; other site 36809003147 catalytic site [active] 36809003148 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 36809003149 Protein of unknown function (DUF466); Region: DUF466; pfam04328 36809003150 carbon starvation protein A; Provisional; Region: PRK15015 36809003151 Carbon starvation protein CstA; Region: CstA; pfam02554 36809003152 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 36809003153 PspC domain; Region: PspC; pfam04024 36809003154 Protein of unknown function, DUF488; Region: DUF488; cl01246 36809003155 GTP-binding protein YchF; Reviewed; Region: PRK09601 36809003156 YchF GTPase; Region: YchF; cd01900 36809003157 G1 box; other site 36809003158 GTP/Mg2+ binding site [chemical binding]; other site 36809003159 Switch I region; other site 36809003160 G2 box; other site 36809003161 Switch II region; other site 36809003162 G3 box; other site 36809003163 G4 box; other site 36809003164 G5 box; other site 36809003165 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 36809003166 Bacterial PH domain; Region: bPH_2; cl01348 36809003167 Predicted membrane protein [Function unknown]; Region: COG3428 36809003168 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 36809003169 The first cupredoxin domain of CumA like multicopper oxidase; Region: CuRO_1_CumA_like; cd13861 36809003170 putative Domain 2 interface [polypeptide binding]; other site 36809003171 putative Domain 3 interface [polypeptide binding]; other site 36809003172 trinuclear Cu binding site [ion binding]; other site 36809003173 Cupredoxin superfamily; Region: Cupredoxin; cl19115 36809003174 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 36809003175 putative Domain 2 interface [polypeptide binding]; other site 36809003176 Type 1 (T1) Cu binding site [ion binding]; other site 36809003177 putative Domain 1 interface [polypeptide binding]; other site 36809003178 trinuclear Cu binding site [ion binding]; other site 36809003179 cysteine synthase; Region: PLN02565 36809003180 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 36809003181 dimer interface [polypeptide binding]; other site 36809003182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003183 catalytic residue [active] 36809003184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003185 multidrug resistance protein MdtH; Provisional; Region: PRK11646 36809003186 putative substrate translocation pore; other site 36809003187 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 36809003188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809003189 ABC transporter; Region: ABC_tran_2; pfam12848 36809003190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809003191 Predicted membrane protein [Function unknown]; Region: COG2259 36809003192 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 36809003193 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 36809003194 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 36809003195 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 36809003196 dimer interface [polypeptide binding]; other site 36809003197 Proteins of 100 residues with WXG; Region: WXG100; cl02005 36809003198 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 36809003199 MMPL family; Region: MMPL; cl14618 36809003200 MMPL family; Region: MMPL; cl14618 36809003201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003203 WHG domain; Region: WHG; pfam13305 36809003204 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 36809003205 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 36809003206 dimer interface [polypeptide binding]; other site 36809003207 catalytic triad [active] 36809003208 peroxidatic and resolving cysteines [active] 36809003209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809003210 S-adenosylmethionine binding site [chemical binding]; other site 36809003211 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 36809003212 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 36809003213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809003214 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809003215 S-adenosylmethionine binding site [chemical binding]; other site 36809003216 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 36809003217 Acyltransferase family; Region: Acyl_transf_3; pfam01757 36809003218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809003220 putative substrate translocation pore; other site 36809003221 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 36809003222 minor groove reading motif; other site 36809003223 helix-hairpin-helix signature motif; other site 36809003224 mannosyltransferase; Provisional; Region: pimE; PRK13375 36809003225 short chain dehydrogenase; Validated; Region: PRK06182 36809003226 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 36809003227 NADP binding site [chemical binding]; other site 36809003228 active site 36809003229 steroid binding site; other site 36809003230 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 36809003231 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 36809003232 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 36809003233 putative active site [active] 36809003234 putative substrate binding site [chemical binding]; other site 36809003235 putative cosubstrate binding site; other site 36809003236 catalytic site [active] 36809003237 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 36809003238 aromatic arch; other site 36809003239 DCoH dimer interaction site [polypeptide binding]; other site 36809003240 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 36809003241 DCoH tetramer interaction site [polypeptide binding]; other site 36809003242 substrate binding site [chemical binding]; other site 36809003243 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 36809003244 active site 36809003245 8-oxo-dGMP binding site [chemical binding]; other site 36809003246 nudix motif; other site 36809003247 metal binding site [ion binding]; metal-binding site 36809003248 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 36809003249 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 36809003250 G1 box; other site 36809003251 putative GEF interaction site [polypeptide binding]; other site 36809003252 GTP/Mg2+ binding site [chemical binding]; other site 36809003253 Switch I region; other site 36809003254 G2 box; other site 36809003255 G3 box; other site 36809003256 Switch II region; other site 36809003257 G4 box; other site 36809003258 G5 box; other site 36809003259 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 36809003260 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 36809003261 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809003262 active site 36809003263 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 36809003264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809003265 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 36809003266 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 36809003267 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 36809003268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809003269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809003270 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 36809003271 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 36809003272 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 36809003273 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 36809003274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809003275 S-adenosylmethionine binding site [chemical binding]; other site 36809003276 FO synthase; Reviewed; Region: fbiC; PRK09234 36809003277 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809003278 FeS/SAM binding site; other site 36809003279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809003280 FeS/SAM binding site; other site 36809003281 Excalibur calcium-binding domain; Region: Excalibur; smart00894 36809003282 MspA; Region: MspA; pfam09203 36809003283 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 36809003284 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 36809003285 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 36809003286 active site 36809003287 FMN binding site [chemical binding]; other site 36809003288 2,4-decadienoyl-CoA binding site; other site 36809003289 catalytic residue [active] 36809003290 4Fe-4S cluster binding site [ion binding]; other site 36809003291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809003292 Predicted transcriptional regulators [Transcription]; Region: COG1695 36809003293 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 36809003294 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 36809003295 Ferredoxin [Energy production and conversion]; Region: COG1146 36809003296 4Fe-4S binding domain; Region: Fer4; pfam00037 36809003297 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 36809003298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809003299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003300 homodimer interface [polypeptide binding]; other site 36809003301 catalytic residue [active] 36809003302 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 36809003303 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 36809003304 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 36809003305 Glutamate binding site [chemical binding]; other site 36809003306 NAD binding site [chemical binding]; other site 36809003307 catalytic residues [active] 36809003308 Proline dehydrogenase; Region: Pro_dh; pfam01619 36809003309 acyl-CoA synthetase; Validated; Region: PRK07787 36809003310 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809003311 acyl-activating enzyme (AAE) consensus motif; other site 36809003312 AMP binding site [chemical binding]; other site 36809003313 active site 36809003314 CoA binding site [chemical binding]; other site 36809003315 DinB superfamily; Region: DinB_2; pfam12867 36809003316 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 36809003317 active site 36809003318 catalytic triad [active] 36809003319 oxyanion hole [active] 36809003320 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 36809003321 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 36809003322 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 36809003323 putative trimer interface [polypeptide binding]; other site 36809003324 putative CoA binding site [chemical binding]; other site 36809003325 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 36809003326 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 36809003327 metal binding site [ion binding]; metal-binding site 36809003328 putative dimer interface [polypeptide binding]; other site 36809003329 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 36809003330 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 36809003331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809003332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003333 putative substrate translocation pore; other site 36809003334 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809003335 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809003336 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 36809003337 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 36809003338 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 36809003339 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 36809003340 acyl-activating enzyme (AAE) consensus motif; other site 36809003341 putative AMP binding site [chemical binding]; other site 36809003342 putative active site [active] 36809003343 putative CoA binding site [chemical binding]; other site 36809003344 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809003345 active site 36809003346 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809003347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809003348 NAD(P) binding site [chemical binding]; other site 36809003349 active site 36809003350 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 36809003351 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 36809003352 substrate binding pocket [chemical binding]; other site 36809003353 dimer interface [polypeptide binding]; other site 36809003354 inhibitor binding site; inhibition site 36809003355 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 36809003356 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 36809003357 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809003358 DivIVA domain; Region: DivI1A_domain; TIGR03544 36809003359 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 36809003360 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 36809003361 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 36809003362 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 36809003363 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 36809003364 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 36809003365 ligand binding site; other site 36809003366 oligomer interface; other site 36809003367 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 36809003368 dimer interface [polypeptide binding]; other site 36809003369 N-terminal domain interface [polypeptide binding]; other site 36809003370 sulfate 1 binding site; other site 36809003371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809003372 DNA-binding site [nucleotide binding]; DNA binding site 36809003373 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 36809003374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809003375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003376 homodimer interface [polypeptide binding]; other site 36809003377 catalytic residue [active] 36809003378 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 36809003379 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 36809003380 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 36809003381 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 36809003382 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 36809003383 Walker A/P-loop; other site 36809003384 ATP binding site [chemical binding]; other site 36809003385 Q-loop/lid; other site 36809003386 ABC transporter signature motif; other site 36809003387 Walker B; other site 36809003388 D-loop; other site 36809003389 H-loop/switch region; other site 36809003390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809003393 S-adenosylmethionine binding site [chemical binding]; other site 36809003394 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 36809003395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809003396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809003397 DNA binding residues [nucleotide binding] 36809003398 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 36809003399 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 36809003400 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 36809003401 protein binding site [polypeptide binding]; other site 36809003402 sec-independent translocase; Provisional; Region: PRK03100 36809003403 Domain of unknown function DUF59; Region: DUF59; cl00941 36809003404 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 36809003405 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 36809003406 Walker A motif; other site 36809003407 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 36809003408 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 36809003409 N-acetyl-D-glucosamine binding site [chemical binding]; other site 36809003410 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 36809003411 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 36809003412 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 36809003413 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 36809003414 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 36809003415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809003416 dimer interface [polypeptide binding]; other site 36809003417 conserved gate region; other site 36809003418 putative PBP binding loops; other site 36809003419 ABC-ATPase subunit interface; other site 36809003420 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 36809003421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809003422 dimer interface [polypeptide binding]; other site 36809003423 conserved gate region; other site 36809003424 putative PBP binding loops; other site 36809003425 ABC-ATPase subunit interface; other site 36809003426 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 36809003427 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 36809003428 Walker A/P-loop; other site 36809003429 ATP binding site [chemical binding]; other site 36809003430 Q-loop/lid; other site 36809003431 ABC transporter signature motif; other site 36809003432 Walker B; other site 36809003433 D-loop; other site 36809003434 H-loop/switch region; other site 36809003435 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 36809003436 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 36809003437 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 36809003438 oligomer interface [polypeptide binding]; other site 36809003439 metal binding site [ion binding]; metal-binding site 36809003440 metal binding site [ion binding]; metal-binding site 36809003441 putative Cl binding site [ion binding]; other site 36809003442 basic sphincter; other site 36809003443 hydrophobic gate; other site 36809003444 periplasmic entrance; other site 36809003445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003447 short chain dehydrogenase; Provisional; Region: PRK07825 36809003448 classical (c) SDRs; Region: SDR_c; cd05233 36809003449 NAD(P) binding site [chemical binding]; other site 36809003450 active site 36809003451 short chain dehydrogenase; Provisional; Region: PRK05650 36809003452 classical (c) SDRs; Region: SDR_c; cd05233 36809003453 NAD(P) binding site [chemical binding]; other site 36809003454 active site 36809003455 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 36809003456 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 36809003457 Malic enzyme, N-terminal domain; Region: malic; pfam00390 36809003458 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 36809003459 putative NAD(P) binding site [chemical binding]; other site 36809003460 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 36809003461 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809003462 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809003463 hypothetical protein; Provisional; Region: PRK06194 36809003464 classical (c) SDRs; Region: SDR_c; cd05233 36809003465 NAD(P) binding site [chemical binding]; other site 36809003466 active site 36809003467 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 36809003468 classical (c) SDRs; Region: SDR_c; cd05233 36809003469 NAD(P) binding site [chemical binding]; other site 36809003470 active site 36809003471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809003472 S-adenosylmethionine binding site [chemical binding]; other site 36809003473 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809003474 Secretory lipase; Region: LIP; pfam03583 36809003475 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 36809003476 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 36809003477 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 36809003478 TPP-binding site [chemical binding]; other site 36809003479 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 36809003480 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 36809003481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003482 putative substrate translocation pore; other site 36809003483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003484 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809003485 putative substrate translocation pore; other site 36809003486 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 36809003487 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 36809003488 FAD binding domain; Region: FAD_binding_4; pfam01565 36809003489 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 36809003490 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 36809003491 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 36809003492 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 36809003493 active site 36809003494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003496 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 36809003497 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 36809003498 RNase_H superfamily; Region: RNase_H_2; pfam13482 36809003499 AAA domain; Region: AAA_11; pfam13086 36809003500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809003501 ATP binding site [chemical binding]; other site 36809003502 putative Mg++ binding site [ion binding]; other site 36809003503 AAA domain; Region: AAA_12; pfam13087 36809003504 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 36809003505 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 36809003506 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 36809003507 ATP binding site [chemical binding]; other site 36809003508 Mg++ binding site [ion binding]; other site 36809003509 motif III; other site 36809003510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809003511 nucleotide binding region [chemical binding]; other site 36809003512 ATP-binding site [chemical binding]; other site 36809003513 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 36809003514 putative RNA binding site [nucleotide binding]; other site 36809003515 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809003516 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809003517 FAD binding domain; Region: FAD_binding_4; pfam01565 36809003518 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 36809003519 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 36809003520 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 36809003521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809003522 NAD(P) binding site [chemical binding]; other site 36809003523 active site 36809003524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003525 H+ Antiporter protein; Region: 2A0121; TIGR00900 36809003526 putative substrate translocation pore; other site 36809003527 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 36809003528 HIT family signature motif; other site 36809003529 catalytic residue [active] 36809003530 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 36809003531 Mechanosensitive ion channel; Region: MS_channel; pfam00924 36809003532 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 36809003533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 36809003534 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 36809003535 Walker A/P-loop; other site 36809003536 ATP binding site [chemical binding]; other site 36809003537 Q-loop/lid; other site 36809003538 ABC transporter signature motif; other site 36809003539 Walker B; other site 36809003540 D-loop; other site 36809003541 H-loop/switch region; other site 36809003542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 36809003543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 36809003544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809003545 Walker A/P-loop; other site 36809003546 ATP binding site [chemical binding]; other site 36809003547 Q-loop/lid; other site 36809003548 ABC transporter signature motif; other site 36809003549 Walker B; other site 36809003550 D-loop; other site 36809003551 H-loop/switch region; other site 36809003552 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809003553 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809003554 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809003555 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809003556 catalytic core [active] 36809003557 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 36809003558 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 36809003559 active site 36809003560 metal binding site [ion binding]; metal-binding site 36809003561 DNA binding site [nucleotide binding] 36809003562 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 36809003563 AAA domain; Region: AAA_23; pfam13476 36809003564 Walker A/P-loop; other site 36809003565 ATP binding site [chemical binding]; other site 36809003566 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 36809003567 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809003568 active site 36809003569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003571 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 36809003572 Cytochrome P450; Region: p450; pfam00067 36809003573 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809003574 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 36809003575 putative active site [active] 36809003576 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 36809003577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003578 putative substrate translocation pore; other site 36809003579 tetracycline repressor protein TetR; Provisional; Region: PRK13756 36809003580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003581 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 36809003582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809003583 hypothetical protein; Provisional; Region: PRK06847 36809003584 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 36809003585 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 36809003586 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 36809003587 active site 36809003588 HIGH motif; other site 36809003589 KMSK motif region; other site 36809003590 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 36809003591 tRNA binding surface [nucleotide binding]; other site 36809003592 anticodon binding site; other site 36809003593 diaminopimelate decarboxylase; Region: lysA; TIGR01048 36809003594 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 36809003595 active site 36809003596 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 36809003597 substrate binding site [chemical binding]; other site 36809003598 catalytic residues [active] 36809003599 dimer interface [polypeptide binding]; other site 36809003600 homoserine dehydrogenase; Provisional; Region: PRK06349 36809003601 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 36809003602 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 36809003603 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 36809003604 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 36809003605 homodimer interface [polypeptide binding]; other site 36809003606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003607 catalytic residue [active] 36809003608 homoserine kinase; Provisional; Region: PRK01212 36809003609 transcription termination factor Rho; Provisional; Region: PRK12678 36809003610 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 36809003611 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 36809003612 RNA binding site [nucleotide binding]; other site 36809003613 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 36809003614 multimer interface [polypeptide binding]; other site 36809003615 Walker A motif; other site 36809003616 ATP binding site [chemical binding]; other site 36809003617 Walker B motif; other site 36809003618 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 36809003619 peptide chain release factor 1; Validated; Region: prfA; PRK00591 36809003620 PCRF domain; Region: PCRF; pfam03462 36809003621 RF-1 domain; Region: RF-1; pfam00472 36809003622 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 36809003623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809003624 S-adenosylmethionine binding site [chemical binding]; other site 36809003625 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 36809003626 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 36809003627 Mg++ binding site [ion binding]; other site 36809003628 putative catalytic motif [active] 36809003629 substrate binding site [chemical binding]; other site 36809003630 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 36809003631 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 36809003632 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 36809003633 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 36809003634 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 36809003635 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 36809003636 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 36809003637 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 36809003638 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 36809003639 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 36809003640 beta subunit interaction interface [polypeptide binding]; other site 36809003641 Walker A motif; other site 36809003642 ATP binding site [chemical binding]; other site 36809003643 Walker B motif; other site 36809003644 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 36809003645 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 36809003646 core domain interface [polypeptide binding]; other site 36809003647 delta subunit interface [polypeptide binding]; other site 36809003648 epsilon subunit interface [polypeptide binding]; other site 36809003649 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 36809003650 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 36809003651 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 36809003652 alpha subunit interaction interface [polypeptide binding]; other site 36809003653 Walker A motif; other site 36809003654 ATP binding site [chemical binding]; other site 36809003655 Walker B motif; other site 36809003656 inhibitor binding site; inhibition site 36809003657 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 36809003658 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 36809003659 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 36809003660 gamma subunit interface [polypeptide binding]; other site 36809003661 epsilon subunit interface [polypeptide binding]; other site 36809003662 LBP interface [polypeptide binding]; other site 36809003663 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 36809003664 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 36809003665 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 36809003666 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 36809003667 hinge; other site 36809003668 active site 36809003669 Domain of unknown function (DUF4436); Region: DUF4436; pfam14494 36809003670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809003671 dimerization interface [polypeptide binding]; other site 36809003672 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 36809003673 cyclase homology domain; Region: CHD; cd07302 36809003674 nucleotidyl binding site; other site 36809003675 metal binding site [ion binding]; metal-binding site 36809003676 dimer interface [polypeptide binding]; other site 36809003677 hypothetical protein; Provisional; Region: PRK03298 36809003678 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 36809003679 dimer interface [polypeptide binding]; other site 36809003680 substrate binding site [chemical binding]; other site 36809003681 metal binding site [ion binding]; metal-binding site 36809003682 putative acyltransferase; Provisional; Region: PRK05790 36809003683 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809003684 dimer interface [polypeptide binding]; other site 36809003685 active site 36809003686 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 36809003687 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 36809003688 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 36809003689 Tetratricopeptide repeat; Region: TPR_20; pfam14561 36809003690 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 36809003691 glycogen branching enzyme; Provisional; Region: PRK05402 36809003692 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 36809003693 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 36809003694 active site 36809003695 catalytic site [active] 36809003696 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 36809003697 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 36809003698 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 36809003699 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 36809003700 active site 36809003701 homodimer interface [polypeptide binding]; other site 36809003702 catalytic site [active] 36809003703 acceptor binding site [chemical binding]; other site 36809003704 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 36809003705 putative homodimer interface [polypeptide binding]; other site 36809003706 putative active site pocket [active] 36809003707 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 36809003708 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 36809003709 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 36809003710 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 36809003711 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 36809003712 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 36809003713 catalytic triad [active] 36809003714 conserved cis-peptide bond; other site 36809003715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003716 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 36809003717 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 36809003718 active site 36809003719 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 36809003720 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 36809003721 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 36809003722 putative active site pocket [active] 36809003723 cleavage site 36809003724 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 36809003725 MPN+ (JAMM) motif; other site 36809003726 Zinc-binding site [ion binding]; other site 36809003727 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 36809003728 MoaE interaction surface [polypeptide binding]; other site 36809003729 MoeB interaction surface [polypeptide binding]; other site 36809003730 thiocarboxylated glycine; other site 36809003731 cysteine synthase; Region: PLN02565 36809003732 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 36809003733 dimer interface [polypeptide binding]; other site 36809003734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809003735 catalytic residue [active] 36809003736 Rhomboid family; Region: Rhomboid; pfam01694 36809003737 glutamate racemase; Provisional; Region: PRK00865 36809003738 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 36809003739 ribonuclease PH; Reviewed; Region: rph; PRK00173 36809003740 Ribonuclease PH; Region: RNase_PH_bact; cd11362 36809003741 hexamer interface [polypeptide binding]; other site 36809003742 active site 36809003743 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 36809003744 active site 36809003745 dimerization interface [polypeptide binding]; other site 36809003746 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809003747 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 36809003748 putative NAD(P) binding site [chemical binding]; other site 36809003749 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 36809003750 Glucitol operon activator protein (GutM); Region: GutM; cl01890 36809003751 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 36809003752 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809003753 acyl-activating enzyme (AAE) consensus motif; other site 36809003754 active site 36809003755 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 36809003756 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 36809003757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 36809003758 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 36809003759 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 36809003760 enoyl-CoA hydratase; Provisional; Region: PRK06563 36809003761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809003762 substrate binding site [chemical binding]; other site 36809003763 oxyanion hole (OAH) forming residues; other site 36809003764 trimer interface [polypeptide binding]; other site 36809003765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003767 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 36809003768 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 36809003769 molybdopterin cofactor binding site; other site 36809003770 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 36809003771 molybdopterin cofactor binding site; other site 36809003772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809003773 hypothetical protein; Provisional; Region: PRK06184 36809003774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003776 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 36809003777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809003778 DNA-binding site [nucleotide binding]; DNA binding site 36809003779 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 36809003780 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 36809003781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809003782 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 36809003783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809003784 motif II; other site 36809003785 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 36809003786 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 36809003787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809003788 Walker A/P-loop; other site 36809003789 ATP binding site [chemical binding]; other site 36809003790 Q-loop/lid; other site 36809003791 ABC transporter signature motif; other site 36809003792 Walker B; other site 36809003793 D-loop; other site 36809003794 H-loop/switch region; other site 36809003795 TOBE domain; Region: TOBE_2; pfam08402 36809003796 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 36809003797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809003798 dimer interface [polypeptide binding]; other site 36809003799 conserved gate region; other site 36809003800 putative PBP binding loops; other site 36809003801 ABC-ATPase subunit interface; other site 36809003802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809003803 dimer interface [polypeptide binding]; other site 36809003804 conserved gate region; other site 36809003805 putative PBP binding loops; other site 36809003806 ABC-ATPase subunit interface; other site 36809003807 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 36809003808 putative active site [active] 36809003809 putative catalytic site [active] 36809003810 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809003811 tetracycline repressor protein TetR; Provisional; Region: PRK13756 36809003812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003813 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 36809003814 Predicted membrane protein [Function unknown]; Region: COG4425 36809003815 Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420 36809003816 Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081 36809003817 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809003818 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809003819 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 36809003820 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 36809003821 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 36809003822 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 36809003823 phosphate binding site [ion binding]; other site 36809003824 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 36809003825 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 36809003826 putative active site [active] 36809003827 putative catalytic site [active] 36809003828 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 36809003829 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 36809003830 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 36809003831 putative NAD(P) binding site [chemical binding]; other site 36809003832 active site 36809003833 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 36809003834 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 36809003835 active site 36809003836 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 36809003837 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 36809003838 nudix motif; other site 36809003839 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 36809003840 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 36809003841 catalytic triad [active] 36809003842 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 36809003843 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 36809003844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003845 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 36809003846 Transport protein; Region: actII; TIGR00833 36809003847 MMPL family; Region: MMPL; pfam03176 36809003848 MMPL family; Region: MMPL; cl14618 36809003849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 36809003850 Histidine kinase; Region: HisKA_3; pfam07730 36809003851 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 36809003852 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809003853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809003854 active site 36809003855 phosphorylation site [posttranslational modification] 36809003856 intermolecular recognition site; other site 36809003857 dimerization interface [polypeptide binding]; other site 36809003858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809003859 DNA binding residues [nucleotide binding] 36809003860 dimerization interface [polypeptide binding]; other site 36809003861 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 36809003862 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 36809003863 PRC-barrel domain; Region: PRC; pfam05239 36809003864 MgtE intracellular N domain; Region: MgtE_N; smart00924 36809003865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 36809003866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003868 short chain dehydrogenase; Provisional; Region: PRK07825 36809003869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809003870 NAD(P) binding site [chemical binding]; other site 36809003871 active site 36809003872 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809003873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809003874 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 36809003875 active site 36809003876 catalytic tetrad [active] 36809003877 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809003878 active site 36809003879 catalytic site [active] 36809003880 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 36809003881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 36809003882 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 36809003883 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 36809003884 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 36809003885 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 36809003886 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 36809003887 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 36809003888 catalytic site [active] 36809003889 putative active site [active] 36809003890 putative substrate binding site [chemical binding]; other site 36809003891 dimer interface [polypeptide binding]; other site 36809003892 Domain of unknown function DUF87; Region: DUF87; cl19135 36809003893 AAA-like domain; Region: AAA_10; pfam12846 36809003894 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 36809003895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003897 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809003898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809003899 NAD(P) binding site [chemical binding]; other site 36809003900 active site 36809003901 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 36809003902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809003903 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809003904 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 36809003905 Cutinase; Region: Cutinase; pfam01083 36809003906 Amino acid permease; Region: AA_permease_2; pfam13520 36809003907 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 36809003908 catalytic site [active] 36809003909 Protein of unknown function (DUF732); Region: DUF732; pfam05305 36809003910 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 36809003911 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 36809003912 CysD dimerization site [polypeptide binding]; other site 36809003913 G1 box; other site 36809003914 putative GEF interaction site [polypeptide binding]; other site 36809003915 GTP/Mg2+ binding site [chemical binding]; other site 36809003916 Switch I region; other site 36809003917 G2 box; other site 36809003918 G3 box; other site 36809003919 Switch II region; other site 36809003920 G4 box; other site 36809003921 G5 box; other site 36809003922 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 36809003923 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 36809003924 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 36809003925 ligand-binding site [chemical binding]; other site 36809003926 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 36809003927 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 36809003928 Active Sites [active] 36809003929 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 36809003930 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 36809003931 Sulfatase; Region: Sulfatase; cl19157 36809003932 Predicted ATPase [General function prediction only]; Region: COG4637 36809003933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 36809003934 Walker A/P-loop; other site 36809003935 ATP binding site [chemical binding]; other site 36809003936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 36809003937 ABC transporter signature motif; other site 36809003938 Walker B; other site 36809003939 D-loop; other site 36809003940 H-loop/switch region; other site 36809003941 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 36809003942 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 36809003943 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 36809003944 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 36809003945 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 36809003946 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 36809003947 RNA binding site [nucleotide binding]; other site 36809003948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809003949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809003950 Protein of unknown function (DUF732); Region: DUF732; pfam05305 36809003951 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 36809003952 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 36809003953 ligand binding site [chemical binding]; other site 36809003954 flexible hinge region; other site 36809003955 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 36809003956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809003957 Coenzyme A binding pocket [chemical binding]; other site 36809003958 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 36809003959 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 36809003960 Copper resistance protein D; Region: CopD; cl00563 36809003961 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 36809003962 allophanate hydrolase; Provisional; Region: PRK08186 36809003963 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 36809003964 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 36809003965 dimer interface [polypeptide binding]; other site 36809003966 ssDNA binding site [nucleotide binding]; other site 36809003967 tetramer (dimer of dimers) interface [polypeptide binding]; other site 36809003968 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 36809003969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809003970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809003971 Walker A/P-loop; other site 36809003972 ATP binding site [chemical binding]; other site 36809003973 Q-loop/lid; other site 36809003974 ABC transporter signature motif; other site 36809003975 ABC transporter; Region: ABC_tran_2; pfam12848 36809003976 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809003977 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 36809003978 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 36809003979 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 36809003980 active site 36809003981 Pirin-related protein [General function prediction only]; Region: COG1741 36809003982 Pirin; Region: Pirin; pfam02678 36809003983 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 36809003984 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 36809003985 active site 36809003986 catalytic site [active] 36809003987 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 36809003988 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 36809003989 apolar tunnel; other site 36809003990 heme binding site [chemical binding]; other site 36809003991 dimerization interface [polypeptide binding]; other site 36809003992 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809003993 active site 36809003994 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 36809003995 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 36809003996 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 36809003997 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 36809003998 Zn binding site [ion binding]; other site 36809003999 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 36809004000 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 36809004001 Peptidase family M48; Region: Peptidase_M48; cl12018 36809004002 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 36809004003 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 36809004004 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 36809004005 putative DNA binding site [nucleotide binding]; other site 36809004006 catalytic residue [active] 36809004007 putative H2TH interface [polypeptide binding]; other site 36809004008 putative catalytic residues [active] 36809004009 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 36809004010 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 36809004011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809004013 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 36809004014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004015 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809004016 Predicted esterase [General function prediction only]; Region: COG0627 36809004017 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809004018 trigger factor; Provisional; Region: tig; PRK01490 36809004019 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 36809004020 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 36809004021 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 36809004022 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 36809004023 oligomer interface [polypeptide binding]; other site 36809004024 active site residues [active] 36809004025 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 36809004026 oligomer interface [polypeptide binding]; other site 36809004027 active site residues [active] 36809004028 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 36809004029 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 36809004030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809004031 Walker A motif; other site 36809004032 ATP binding site [chemical binding]; other site 36809004033 Walker B motif; other site 36809004034 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 36809004035 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809004036 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 36809004037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 36809004038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809004039 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 36809004040 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 36809004041 putative di-iron ligands [ion binding]; other site 36809004042 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 36809004043 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 36809004044 FAD binding pocket [chemical binding]; other site 36809004045 FAD binding motif [chemical binding]; other site 36809004046 phosphate binding motif [ion binding]; other site 36809004047 beta-alpha-beta structure motif; other site 36809004048 NAD binding pocket [chemical binding]; other site 36809004049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809004050 catalytic loop [active] 36809004051 iron binding site [ion binding]; other site 36809004052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809004054 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 36809004055 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 36809004056 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 36809004057 putative molybdopterin cofactor binding site [chemical binding]; other site 36809004058 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 36809004059 putative molybdopterin cofactor binding site; other site 36809004060 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 36809004061 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 36809004062 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 36809004063 dimer interface [polypeptide binding]; other site 36809004064 PYR/PP interface [polypeptide binding]; other site 36809004065 TPP binding site [chemical binding]; other site 36809004066 substrate binding site [chemical binding]; other site 36809004067 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 36809004068 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 36809004069 TPP-binding site [chemical binding]; other site 36809004070 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 36809004071 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 36809004072 GTP binding site; other site 36809004073 YibE/F-like protein; Region: YibE_F; pfam07907 36809004074 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 36809004075 hypothetical protein; Provisional; Region: PRK06847 36809004076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809004077 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 36809004078 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 36809004079 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 36809004080 active site 36809004081 HIGH motif; other site 36809004082 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 36809004083 KMSKS motif; other site 36809004084 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 36809004085 tRNA binding surface [nucleotide binding]; other site 36809004086 anticodon binding site; other site 36809004087 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 36809004088 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 36809004089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 36809004090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 36809004091 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 36809004092 Nucleoside diphosphate kinase; Region: NDK; pfam00334 36809004093 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 36809004094 active site 36809004095 multimer interface [polypeptide binding]; other site 36809004096 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 36809004097 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 36809004098 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 36809004099 homodimer interface [polypeptide binding]; other site 36809004100 oligonucleotide binding site [chemical binding]; other site 36809004101 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 36809004102 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 36809004103 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 36809004104 GTPase CgtA; Reviewed; Region: obgE; PRK12296 36809004105 GTP1/OBG; Region: GTP1_OBG; pfam01018 36809004106 Obg GTPase; Region: Obg; cd01898 36809004107 G1 box; other site 36809004108 GTP/Mg2+ binding site [chemical binding]; other site 36809004109 Switch I region; other site 36809004110 G2 box; other site 36809004111 G3 box; other site 36809004112 Switch II region; other site 36809004113 G4 box; other site 36809004114 G5 box; other site 36809004115 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 36809004116 gamma-glutamyl kinase; Provisional; Region: PRK05429 36809004117 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 36809004118 nucleotide binding site [chemical binding]; other site 36809004119 homotetrameric interface [polypeptide binding]; other site 36809004120 putative phosphate binding site [ion binding]; other site 36809004121 putative allosteric binding site; other site 36809004122 PUA domain; Region: PUA; pfam01472 36809004123 N-terminal domain of eIF2D, malignant T cell-amplified sequence 1 and related proteins; Region: eIF2D_N_like; cl16921 36809004124 Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312 36809004125 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 36809004126 substrate binding site [chemical binding]; other site 36809004127 dimer interface [polypeptide binding]; other site 36809004128 ATP binding site [chemical binding]; other site 36809004129 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 36809004130 putative catalytic cysteine [active] 36809004131 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 36809004132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809004133 Walker A motif; other site 36809004134 ATP binding site [chemical binding]; other site 36809004135 Walker B motif; other site 36809004136 arginine finger; other site 36809004137 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 36809004138 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 36809004139 metal ion-dependent adhesion site (MIDAS); other site 36809004140 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 36809004141 active site 36809004142 (T/H)XGH motif; other site 36809004143 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 36809004144 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809004145 catalytic core [active] 36809004146 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 36809004147 active site 36809004148 catalytic triad [active] 36809004149 oxyanion hole [active] 36809004150 EDD domain protein, DegV family; Region: DegV; TIGR00762 36809004151 SLBB domain; Region: SLBB; pfam10531 36809004152 comEA protein; Region: comE; TIGR01259 36809004153 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 36809004154 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 36809004155 Competence protein; Region: Competence; pfam03772 36809004156 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 36809004157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809004158 Flagellar L-ring protein; Region: FlgH; cl19182 36809004159 hypothetical protein; Reviewed; Region: PRK07914 36809004160 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 36809004161 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 36809004162 Uncharacterized conserved protein [Function unknown]; Region: COG2308 36809004163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 36809004164 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 36809004165 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 36809004166 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 36809004167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004168 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809004169 PemK-like protein; Region: PemK; pfam02452 36809004170 GTP-binding protein LepA; Provisional; Region: PRK05433 36809004171 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 36809004172 G1 box; other site 36809004173 putative GEF interaction site [polypeptide binding]; other site 36809004174 GTP/Mg2+ binding site [chemical binding]; other site 36809004175 Switch I region; other site 36809004176 G2 box; other site 36809004177 G3 box; other site 36809004178 Switch II region; other site 36809004179 G4 box; other site 36809004180 G5 box; other site 36809004181 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 36809004182 Elongation Factor G, domain II; Region: EFG_II; pfam14492 36809004183 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 36809004184 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 36809004185 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 36809004186 Nitronate monooxygenase; Region: NMO; pfam03060 36809004187 FMN binding site [chemical binding]; other site 36809004188 substrate binding site [chemical binding]; other site 36809004189 putative catalytic residue [active] 36809004190 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 36809004191 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 36809004192 biotin carboxyl carrier protein of acetyl-CoA carboxylase; Region: PLN02983 36809004193 hypothetical protein; Provisional; Region: PRK06185 36809004194 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809004195 YtkA-like; Region: YtkA; pfam13115 36809004196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 36809004197 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 36809004198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809004199 dimer interface [polypeptide binding]; other site 36809004200 conserved gate region; other site 36809004201 putative PBP binding loops; other site 36809004202 ABC-ATPase subunit interface; other site 36809004203 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 36809004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809004205 dimer interface [polypeptide binding]; other site 36809004206 conserved gate region; other site 36809004207 putative PBP binding loops; other site 36809004208 ABC-ATPase subunit interface; other site 36809004209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809004210 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 36809004211 Walker A/P-loop; other site 36809004212 ATP binding site [chemical binding]; other site 36809004213 Q-loop/lid; other site 36809004214 ABC transporter signature motif; other site 36809004215 Walker B; other site 36809004216 D-loop; other site 36809004217 H-loop/switch region; other site 36809004218 TOBE-like domain; Region: TOBE_3; pfam12857 36809004219 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 36809004220 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 36809004221 putative active site [active] 36809004222 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 36809004223 active site 36809004224 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 36809004225 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 36809004226 CysD dimerization site [polypeptide binding]; other site 36809004227 G1 box; other site 36809004228 putative GEF interaction site [polypeptide binding]; other site 36809004229 GTP/Mg2+ binding site [chemical binding]; other site 36809004230 Switch I region; other site 36809004231 G2 box; other site 36809004232 G3 box; other site 36809004233 Switch II region; other site 36809004234 G4 box; other site 36809004235 G5 box; other site 36809004236 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 36809004237 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 36809004238 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 36809004239 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 36809004240 Active Sites [active] 36809004241 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 36809004242 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 36809004243 Active Sites [active] 36809004244 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 36809004245 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 36809004246 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 36809004247 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 36809004248 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 36809004249 coproporphyrinogen III oxidase; Validated; Region: PRK05628 36809004250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809004251 FeS/SAM binding site; other site 36809004252 HemN C-terminal domain; Region: HemN_C; pfam06969 36809004253 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 36809004254 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 36809004255 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 36809004256 HrcA protein C terminal domain; Region: HrcA; pfam01628 36809004257 chaperone protein DnaJ; Provisional; Region: PRK14278 36809004258 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 36809004259 HSP70 interaction site [polypeptide binding]; other site 36809004260 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 36809004261 Zn binding sites [ion binding]; other site 36809004262 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 36809004263 dimer interface [polypeptide binding]; other site 36809004264 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 36809004265 K homology RNA-binding domain; Region: KH; smart00322 36809004266 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 36809004267 PhoH-like protein; Region: PhoH; pfam02562 36809004268 metal-binding heat shock protein; Provisional; Region: PRK00016 36809004269 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 36809004270 Domain of unknown function DUF21; Region: DUF21; pfam01595 36809004271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 36809004272 Transporter associated domain; Region: CorC_HlyC; smart01091 36809004273 enolase; Provisional; Region: eno; PRK00077 36809004274 GTPase Era; Reviewed; Region: era; PRK00089 36809004275 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 36809004276 G1 box; other site 36809004277 GTP/Mg2+ binding site [chemical binding]; other site 36809004278 Switch I region; other site 36809004279 G2 box; other site 36809004280 Switch II region; other site 36809004281 G3 box; other site 36809004282 G4 box; other site 36809004283 G5 box; other site 36809004284 KH domain; Region: KH_2; pfam07650 36809004285 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 36809004286 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 36809004287 amidase; Provisional; Region: PRK06061 36809004288 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 36809004289 Recombination protein O N terminal; Region: RecO_N; pfam11967 36809004290 Recombination protein O C terminal; Region: RecO_C; pfam02565 36809004291 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 36809004292 active site 36809004293 dimer interface [polypeptide binding]; other site 36809004294 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 36809004295 metal binding site 2 [ion binding]; metal-binding site 36809004296 putative DNA binding helix; other site 36809004297 metal binding site 1 [ion binding]; metal-binding site 36809004298 dimer interface [polypeptide binding]; other site 36809004299 structural Zn2+ binding site [ion binding]; other site 36809004300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809004301 dimerization interface [polypeptide binding]; other site 36809004302 putative DNA binding site [nucleotide binding]; other site 36809004303 putative Zn2+ binding site [ion binding]; other site 36809004304 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 36809004305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809004306 NAD(P) binding site [chemical binding]; other site 36809004307 active site 36809004308 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 36809004309 Fatty acid desaturase; Region: FA_desaturase; pfam00487 36809004310 putative di-iron ligands [ion binding]; other site 36809004311 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809004312 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809004313 inhibitor-cofactor binding pocket; inhibition site 36809004314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809004315 catalytic residue [active] 36809004316 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 36809004317 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809004318 catalytic residue [active] 36809004319 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809004320 hydrophobic ligand binding site; other site 36809004321 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 36809004322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809004323 Walker A/P-loop; other site 36809004324 ATP binding site [chemical binding]; other site 36809004325 Q-loop/lid; other site 36809004326 ABC transporter signature motif; other site 36809004327 Walker B; other site 36809004328 D-loop; other site 36809004329 H-loop/switch region; other site 36809004330 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 36809004331 ABC-2 type transporter; Region: ABC2_membrane; cl17235 36809004332 Phosphopantetheine attachment site; Region: PP-binding; cl09936 36809004333 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 36809004334 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809004335 acyl-activating enzyme (AAE) consensus motif; other site 36809004336 active site 36809004337 Permease; Region: Permease; pfam02405 36809004338 Permease; Region: Permease; pfam02405 36809004339 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 36809004340 mce related protein; Region: MCE; pfam02470 36809004341 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 36809004342 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 36809004343 mce related protein; Region: MCE; pfam02470 36809004344 mce related protein; Region: MCE; pfam02470 36809004345 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809004346 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809004347 mce related protein; Region: MCE; pfam02470 36809004348 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809004349 mce related protein; Region: MCE; pfam02470 36809004350 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809004351 mce related protein; Region: MCE; pfam02470 36809004352 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 36809004353 glycyl-tRNA synthetase; Provisional; Region: PRK04173 36809004354 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 36809004355 dimer interface [polypeptide binding]; other site 36809004356 motif 1; other site 36809004357 active site 36809004358 motif 2; other site 36809004359 motif 3; other site 36809004360 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 36809004361 anticodon binding site; other site 36809004362 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809004363 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809004364 inhibitor-cofactor binding pocket; inhibition site 36809004365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809004366 catalytic residue [active] 36809004367 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 36809004368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809004369 catalytic residue [active] 36809004370 transcriptional regulator NanR; Provisional; Region: PRK03837 36809004371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809004372 DNA-binding site [nucleotide binding]; DNA binding site 36809004373 FCD domain; Region: FCD; pfam07729 36809004374 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 36809004375 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 36809004376 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 36809004377 Zn2+ binding site [ion binding]; other site 36809004378 Mg2+ binding site [ion binding]; other site 36809004379 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 36809004380 DNA primase; Validated; Region: dnaG; PRK05667 36809004381 CHC2 zinc finger; Region: zf-CHC2; pfam01807 36809004382 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 36809004383 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 36809004384 active site 36809004385 metal binding site [ion binding]; metal-binding site 36809004386 interdomain interaction site; other site 36809004387 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 36809004388 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 36809004389 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809004390 CCC1-related family of proteins; Region: CCC1_like; cl00278 36809004391 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 36809004392 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 36809004393 Walker A/P-loop; other site 36809004394 ATP binding site [chemical binding]; other site 36809004395 Q-loop/lid; other site 36809004396 ABC transporter signature motif; other site 36809004397 Walker B; other site 36809004398 D-loop; other site 36809004399 H-loop/switch region; other site 36809004400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 36809004401 Walker A/P-loop; other site 36809004402 ATP binding site [chemical binding]; other site 36809004403 Q-loop/lid; other site 36809004404 ABC transporter signature motif; other site 36809004405 Walker B; other site 36809004406 D-loop; other site 36809004407 H-loop/switch region; other site 36809004408 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 36809004409 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 36809004410 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 36809004411 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 36809004412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809004413 dimer interface [polypeptide binding]; other site 36809004414 conserved gate region; other site 36809004415 putative PBP binding loops; other site 36809004416 ABC-ATPase subunit interface; other site 36809004417 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 36809004418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809004419 ABC-ATPase subunit interface; other site 36809004420 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 36809004421 Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356 36809004422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809004423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809004424 active site 36809004425 phosphorylation site [posttranslational modification] 36809004426 intermolecular recognition site; other site 36809004427 dimerization interface [polypeptide binding]; other site 36809004428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809004429 DNA binding site [nucleotide binding] 36809004430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809004431 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809004432 dimerization interface [polypeptide binding]; other site 36809004433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809004434 dimer interface [polypeptide binding]; other site 36809004435 phosphorylation site [posttranslational modification] 36809004436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809004437 ATP binding site [chemical binding]; other site 36809004438 Mg2+ binding site [ion binding]; other site 36809004439 G-X-G motif; other site 36809004440 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 36809004441 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 36809004442 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 36809004443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 36809004444 active site 36809004445 DNA binding site [nucleotide binding] 36809004446 Int/Topo IB signature motif; other site 36809004447 Protein of unknown function (DUF732); Region: DUF732; pfam05305 36809004448 Protein of unknown function (DUF732); Region: DUF732; pfam05305 36809004449 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809004450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809004451 non-specific DNA binding site [nucleotide binding]; other site 36809004452 salt bridge; other site 36809004453 sequence-specific DNA binding site [nucleotide binding]; other site 36809004454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809004455 non-specific DNA binding site [nucleotide binding]; other site 36809004456 salt bridge; other site 36809004457 sequence-specific DNA binding site [nucleotide binding]; other site 36809004458 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 36809004459 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 36809004460 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809004461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809004462 non-specific DNA binding site [nucleotide binding]; other site 36809004463 salt bridge; other site 36809004464 sequence-specific DNA binding site [nucleotide binding]; other site 36809004465 Protein of unknown function (DUF732); Region: DUF732; pfam05305 36809004466 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 36809004467 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 36809004468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809004469 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809004470 non-specific DNA binding site [nucleotide binding]; other site 36809004471 salt bridge; other site 36809004472 sequence-specific DNA binding site [nucleotide binding]; other site 36809004473 ERF superfamily; Region: ERF; pfam04404 36809004474 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809004475 active site 36809004476 Conjugal transfer protein TrbH; Region: TrbH; cl19428 36809004477 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 36809004478 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 36809004479 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 36809004480 Transcription factor WhiB; Region: Whib; pfam02467 36809004481 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 36809004482 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 36809004483 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809004484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809004485 non-specific DNA binding site [nucleotide binding]; other site 36809004486 salt bridge; other site 36809004487 sequence-specific DNA binding site [nucleotide binding]; other site 36809004488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 36809004489 active site 36809004490 Methyltransferase domain; Region: Methyltransf_24; pfam13578 36809004491 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 36809004492 Phage Terminase; Region: Terminase_1; cl19862 36809004493 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531 36809004494 P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl19542 36809004495 Phage-related minor tail protein [Function unknown]; Region: COG5280 36809004496 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 36809004497 Protein of unknown function (DUF996); Region: DUF996; cl00970 36809004498 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 36809004499 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809004500 SLAIN motif-containing family; Region: SLAIN; pfam15301 36809004501 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 36809004502 catalytic residue [active] 36809004503 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 36809004504 active site 36809004505 metal binding site [ion binding]; metal-binding site 36809004506 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809004507 active site 36809004508 Protein of unknown function (DUF2746); Region: DUF2746; pfam10874 36809004509 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 36809004510 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 36809004511 active site 36809004512 DNA binding site [nucleotide binding] 36809004513 Int/Topo IB signature motif; other site 36809004514 Helix-turn-helix domain; Region: HTH_17; pfam12728 36809004515 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 36809004516 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 36809004517 multiple promoter invertase; Provisional; Region: mpi; PRK13413 36809004518 catalytic residues [active] 36809004519 catalytic nucleophile [active] 36809004520 Presynaptic Site I dimer interface [polypeptide binding]; other site 36809004521 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 36809004522 Synaptic Flat tetramer interface [polypeptide binding]; other site 36809004523 Synaptic Site I dimer interface [polypeptide binding]; other site 36809004524 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 36809004525 DNA-binding interface [nucleotide binding]; DNA binding site 36809004526 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809004527 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 36809004528 NlpC/P60 family; Region: NLPC_P60; cl17555 36809004529 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809004530 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 36809004531 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 36809004532 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 36809004533 active site 36809004534 Zn binding site [ion binding]; other site 36809004535 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 36809004536 metal binding site [ion binding]; metal-binding site 36809004537 active site 36809004538 I-site; other site 36809004539 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 36809004540 active site 36809004541 catalytic residues [active] 36809004542 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 36809004543 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 36809004544 putative heme binding pocket [chemical binding]; other site 36809004545 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 36809004546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809004547 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 36809004548 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809004549 AAA ATPase domain; Region: AAA_16; pfam13191 36809004550 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 36809004551 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 36809004552 active site 36809004553 Zn binding site [ion binding]; other site 36809004554 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 36809004555 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 36809004556 active site 36809004557 Zn binding site [ion binding]; other site 36809004558 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809004559 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809004560 active site 36809004561 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 36809004562 catalytic triad [active] 36809004563 conserved cis-peptide bond; other site 36809004564 TIGR03086 family protein; Region: TIGR03086 36809004565 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 36809004566 homodimer interface [polypeptide binding]; other site 36809004567 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 36809004568 active site pocket [active] 36809004569 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809004570 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 36809004571 NAD(P) binding site [chemical binding]; other site 36809004572 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809004573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809004574 dimerization interface [polypeptide binding]; other site 36809004575 putative Zn2+ binding site [ion binding]; other site 36809004576 putative DNA binding site [nucleotide binding]; other site 36809004577 MarR family; Region: MarR_2; cl17246 36809004578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 36809004579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809004580 Walker A/P-loop; other site 36809004581 ATP binding site [chemical binding]; other site 36809004582 Q-loop/lid; other site 36809004583 ABC transporter signature motif; other site 36809004584 Walker B; other site 36809004585 D-loop; other site 36809004586 H-loop/switch region; other site 36809004587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809004589 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 36809004590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809004591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809004592 active site 36809004593 lipid-transfer protein; Provisional; Region: PRK08256 36809004594 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809004595 active site 36809004596 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 36809004597 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 36809004598 acyl-activating enzyme (AAE) consensus motif; other site 36809004599 putative AMP binding site [chemical binding]; other site 36809004600 putative active site [active] 36809004601 putative CoA binding site [chemical binding]; other site 36809004602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809004603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 36809004604 metal binding site [ion binding]; metal-binding site 36809004605 active site 36809004606 I-site; other site 36809004607 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 36809004608 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 36809004609 active site 36809004610 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 36809004611 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 36809004612 NAD binding site [chemical binding]; other site 36809004613 catalytic Zn binding site [ion binding]; other site 36809004614 substrate binding site [chemical binding]; other site 36809004615 structural Zn binding site [ion binding]; other site 36809004616 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809004617 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 36809004618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809004620 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809004621 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 36809004622 putative NAD(P) binding site [chemical binding]; other site 36809004623 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809004624 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809004625 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809004626 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 36809004627 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809004628 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809004629 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 36809004630 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 36809004631 dimer interface [polypeptide binding]; other site 36809004632 active site 36809004633 acyl carrier protein; Provisional; Region: acpP; PRK00982 36809004634 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 36809004635 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 36809004636 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809004637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809004639 Electron transfer DM13; Region: DM13; cl02735 36809004640 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 36809004641 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 36809004642 dimer interface [polypeptide binding]; other site 36809004643 TPP-binding site [chemical binding]; other site 36809004644 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 36809004645 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 36809004646 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 36809004647 dimer interface [polypeptide binding]; other site 36809004648 catalytic triad [active] 36809004649 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 36809004650 active site 36809004651 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 36809004652 MspA; Region: MspA; pfam09203 36809004653 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 36809004654 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 36809004655 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 36809004656 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 36809004657 Low molecular weight phosphatase family; Region: LMWPc; cd00115 36809004658 active site 36809004659 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 36809004660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809004661 active site 36809004662 motif I; other site 36809004663 motif II; other site 36809004664 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 36809004665 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809004666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809004667 homodimer interface [polypeptide binding]; other site 36809004668 catalytic residue [active] 36809004669 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 36809004670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 36809004671 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 36809004672 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 36809004673 Putative zinc ribbon domain; Region: DUF164; pfam02591 36809004674 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 36809004675 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 36809004676 RNA/DNA hybrid binding site [nucleotide binding]; other site 36809004677 active site 36809004678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809004679 catalytic core [active] 36809004680 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 36809004681 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 36809004682 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 36809004683 Domain of unknown function (DUF222); Region: DUF222; pfam02720 36809004684 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809004685 active site 36809004686 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 36809004687 Protein of unknown function DUF58; Region: DUF58; pfam01882 36809004688 MoxR-like ATPases [General function prediction only]; Region: COG0714 36809004689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809004690 Walker A motif; other site 36809004691 ATP binding site [chemical binding]; other site 36809004692 Walker B motif; other site 36809004693 arginine finger; other site 36809004694 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 36809004695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809004696 active site 36809004697 RNB domain; Region: RNB; pfam00773 36809004698 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 36809004699 putative active site; other site 36809004700 putative metal binding residues [ion binding]; other site 36809004701 signature motif; other site 36809004702 putative triphosphate binding site [ion binding]; other site 36809004703 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 36809004704 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 36809004705 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809004706 acyl-activating enzyme (AAE) consensus motif; other site 36809004707 active site 36809004708 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 36809004709 oligomerization interface [polypeptide binding]; other site 36809004710 active site 36809004711 metal binding site [ion binding]; metal-binding site 36809004712 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 36809004713 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 36809004714 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 36809004715 TAP-like protein; Region: Abhydrolase_4; pfam08386 36809004716 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 36809004717 TAP-like protein; Region: Abhydrolase_4; pfam08386 36809004718 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 36809004719 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 36809004720 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 36809004721 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 36809004722 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 36809004723 metal binding triad; other site 36809004724 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 36809004725 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 36809004726 metal binding triad; other site 36809004727 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 36809004728 Domain of unknown function DUF148; Region: DUF148; pfam02520 36809004729 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809004730 active site 36809004731 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809004732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809004733 conjugal transfer protein TraD; Provisional; Region: PRK13700 36809004734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809004735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809004736 active site 36809004737 phosphorylation site [posttranslational modification] 36809004738 intermolecular recognition site; other site 36809004739 dimerization interface [polypeptide binding]; other site 36809004740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809004741 DNA binding site [nucleotide binding] 36809004742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809004743 HAMP domain; Region: HAMP; pfam00672 36809004744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809004745 phosphorylation site [posttranslational modification] 36809004746 dimer interface [polypeptide binding]; other site 36809004747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809004748 ATP binding site [chemical binding]; other site 36809004749 Mg2+ binding site [ion binding]; other site 36809004750 G-X-G motif; other site 36809004751 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809004752 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 36809004753 putative catalytic site [active] 36809004754 putative metal binding site [ion binding]; other site 36809004755 putative phosphate binding site [ion binding]; other site 36809004756 putative catalytic site [active] 36809004757 putative phosphate binding site [ion binding]; other site 36809004758 putative metal binding site [ion binding]; other site 36809004759 Predicted membrane protein [Function unknown]; Region: COG2259 36809004760 Predicted membrane protein [Function unknown]; Region: COG2259 36809004761 chaperone protein HchA; Provisional; Region: PRK04155 36809004762 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 36809004763 conserved cys residue [active] 36809004764 glutamine synthetase, type I; Region: GlnA; TIGR00653 36809004765 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 36809004766 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 36809004767 RDD family; Region: RDD; pfam06271 36809004768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809004769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809004770 putative substrate translocation pore; other site 36809004771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 36809004772 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 36809004773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809004774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809004776 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809004777 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 36809004778 lipoyl synthase; Provisional; Region: PRK05481 36809004779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809004780 FeS/SAM binding site; other site 36809004781 lipoate-protein ligase B; Provisional; Region: PRK14345 36809004782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809004783 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 36809004784 NAD(P) binding site [chemical binding]; other site 36809004785 active site 36809004786 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 36809004787 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 36809004788 E3 interaction surface; other site 36809004789 lipoyl attachment site [posttranslational modification]; other site 36809004790 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 36809004791 E3 interaction surface; other site 36809004792 lipoyl attachment site [posttranslational modification]; other site 36809004793 e3 binding domain; Region: E3_binding; pfam02817 36809004794 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 36809004795 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 36809004796 multifunctional aminopeptidase A; Provisional; Region: PRK00913 36809004797 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 36809004798 interface (dimer of trimers) [polypeptide binding]; other site 36809004799 Substrate-binding/catalytic site; other site 36809004800 Zn-binding sites [ion binding]; other site 36809004801 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 36809004802 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 36809004803 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 36809004804 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 36809004805 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 36809004806 homodimer interface [polypeptide binding]; other site 36809004807 substrate-cofactor binding pocket; other site 36809004808 catalytic residue [active] 36809004809 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 36809004810 active site 36809004811 metal binding site [ion binding]; metal-binding site 36809004812 cobalamin synthase; Reviewed; Region: cobS; PRK00235 36809004813 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 36809004814 putative dimer interface [polypeptide binding]; other site 36809004815 active site pocket [active] 36809004816 putative cataytic base [active] 36809004817 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 36809004818 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 36809004819 Glycerate kinase family; Region: Gly_kinase; cl00841 36809004820 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 36809004821 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 36809004822 substrate binding site [chemical binding]; other site 36809004823 ATP binding site [chemical binding]; other site 36809004824 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 36809004825 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 36809004826 active site 36809004827 dimer interface [polypeptide binding]; other site 36809004828 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 36809004829 Ligand Binding Site [chemical binding]; other site 36809004830 Molecular Tunnel; other site 36809004831 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 36809004832 Cupredoxin superfamily; Region: Cupredoxin; cl19115 36809004833 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 36809004834 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 36809004835 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 36809004836 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 36809004837 heme bH binding site [chemical binding]; other site 36809004838 Qi binding site; other site 36809004839 intrachain domain interface; other site 36809004840 heme bL binding site [chemical binding]; other site 36809004841 interchain domain interface [polypeptide binding]; other site 36809004842 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 36809004843 Qo binding site; other site 36809004844 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 36809004845 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 36809004846 iron-sulfur cluster [ion binding]; other site 36809004847 [2Fe-2S] cluster binding site [ion binding]; other site 36809004848 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 36809004849 Cytochrome c; Region: Cytochrom_C; pfam00034 36809004850 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 36809004851 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 36809004852 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 36809004853 Subunit I/III interface [polypeptide binding]; other site 36809004854 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 36809004855 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 36809004856 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 36809004857 hypothetical protein; Validated; Region: PRK07883 36809004858 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 36809004859 active site 36809004860 catalytic site [active] 36809004861 substrate binding site [chemical binding]; other site 36809004862 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 36809004863 GIY-YIG motif/motif A; other site 36809004864 active site 36809004865 catalytic site [active] 36809004866 putative DNA binding site [nucleotide binding]; other site 36809004867 metal binding site [ion binding]; metal-binding site 36809004868 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 36809004869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809004870 S-adenosylmethionine binding site [chemical binding]; other site 36809004871 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 36809004872 NlpC/P60 family; Region: NLPC_P60; pfam00877 36809004873 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 36809004874 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 36809004875 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809004876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809004877 S-adenosylmethionine binding site [chemical binding]; other site 36809004878 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 36809004879 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 36809004880 acyl-activating enzyme (AAE) consensus motif; other site 36809004881 putative AMP binding site [chemical binding]; other site 36809004882 putative active site [active] 36809004883 putative CoA binding site [chemical binding]; other site 36809004884 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809004885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809004886 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809004887 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 36809004888 putative hydrophobic ligand binding site [chemical binding]; other site 36809004889 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 36809004890 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 36809004891 P loop; other site 36809004892 Nucleotide binding site [chemical binding]; other site 36809004893 DTAP/Switch II; other site 36809004894 Switch I; other site 36809004895 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 36809004896 putative acyl-acceptor binding pocket; other site 36809004897 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 36809004898 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 36809004899 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 36809004900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 36809004901 active site 36809004902 ATP binding site [chemical binding]; other site 36809004903 substrate binding site [chemical binding]; other site 36809004904 activation loop (A-loop); other site 36809004905 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 36809004906 putative hydrophobic ligand binding site [chemical binding]; other site 36809004907 Helix-turn-helix domain; Region: HTH_17; pfam12728 36809004908 EEV maturation protein; Provisional; Region: PHA02952 36809004909 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 36809004910 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 36809004911 substrate binding pocket [chemical binding]; other site 36809004912 chain length determination region; other site 36809004913 substrate-Mg2+ binding site; other site 36809004914 catalytic residues [active] 36809004915 aspartate-rich region 1; other site 36809004916 active site lid residues [active] 36809004917 aspartate-rich region 2; other site 36809004918 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 36809004919 FAD binding site [chemical binding]; other site 36809004920 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 36809004921 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 36809004922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809004923 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 36809004924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 36809004925 MraZ protein; Region: MraZ; pfam02381 36809004926 MraZ protein; Region: MraZ; pfam02381 36809004927 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 36809004928 EBNA-3C; Provisional; Region: PHA03377 36809004929 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 36809004930 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 36809004931 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 36809004932 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 36809004933 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 36809004934 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 36809004935 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 36809004936 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 36809004937 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 36809004938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 36809004939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 36809004940 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 36809004941 Mg++ binding site [ion binding]; other site 36809004942 putative catalytic motif [active] 36809004943 putative substrate binding site [chemical binding]; other site 36809004944 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 36809004945 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 36809004946 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 36809004947 cell division protein FtsW; Region: ftsW; TIGR02614 36809004948 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 36809004949 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 36809004950 active site 36809004951 homodimer interface [polypeptide binding]; other site 36809004952 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 36809004953 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 36809004954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 36809004955 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 36809004956 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 36809004957 Cell division protein FtsQ; Region: FtsQ; pfam03799 36809004958 cell division protein FtsZ; Validated; Region: PRK09330 36809004959 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 36809004960 nucleotide binding site [chemical binding]; other site 36809004961 SulA interaction site; other site 36809004962 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 36809004963 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 36809004964 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 36809004965 catalytic residue [active] 36809004966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 36809004967 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 36809004968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809004969 dimerization interface [polypeptide binding]; other site 36809004970 putative DNA binding site [nucleotide binding]; other site 36809004971 putative Zn2+ binding site [ion binding]; other site 36809004972 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 36809004973 putative hydrophobic ligand binding site [chemical binding]; other site 36809004974 Predicted integral membrane protein [Function unknown]; Region: COG0762 36809004975 DivIVA protein; Region: DivIVA; pfam05103 36809004976 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 36809004977 Flagellar assembly protein FliH; Region: FliH; cl19405 36809004978 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 36809004979 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809004980 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809004981 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809004982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809004983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809004984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 36809004985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 36809004986 DNA binding site [nucleotide binding] 36809004987 domain linker motif; other site 36809004988 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 36809004989 amidase; Validated; Region: PRK06565 36809004990 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 36809004991 Amidinotransferase; Region: Amidinotransf; cl19186 36809004992 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 36809004993 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 36809004994 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 36809004995 dimer interface [polypeptide binding]; other site 36809004996 active site 36809004997 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 36809004998 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 36809004999 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 36809005000 dimer interface [polypeptide binding]; other site 36809005001 active site 36809005002 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 36809005003 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 36809005004 active site 36809005005 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 36809005006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809005007 NAD(P) binding site [chemical binding]; other site 36809005008 active site 36809005009 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 36809005010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809005011 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 36809005012 acyltransferase PapA5; Provisional; Region: PRK09294 36809005013 Condensation domain; Region: Condensation; cl19241 36809005014 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809005015 Transport protein; Region: actII; TIGR00833 36809005016 MMPL family; Region: MMPL; pfam03176 36809005017 MMPL family; Region: MMPL; pfam03176 36809005018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809005019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809005020 putative substrate translocation pore; other site 36809005021 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809005022 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809005023 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809005024 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809005025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 36809005026 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 36809005027 NAD(P) binding site [chemical binding]; other site 36809005028 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 36809005029 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 36809005030 active site 36809005031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809005033 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809005034 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 36809005035 CoenzymeA binding site [chemical binding]; other site 36809005036 subunit interaction site [polypeptide binding]; other site 36809005037 PHB binding site; other site 36809005038 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809005039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809005040 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809005041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809005043 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 36809005044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809005045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809005046 Reductase C-terminal; Region: Reductase_C; pfam14759 36809005047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809005048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809005049 catalytic loop [active] 36809005050 iron binding site [ion binding]; other site 36809005051 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 36809005052 Uncharacterized ACR, COG1753; Region: DUF217; cl00762 36809005053 Helix-turn-helix domain; Region: HTH_18; pfam12833 36809005054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809005055 thiolase; Provisional; Region: PRK06158 36809005056 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809005057 active site 36809005058 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 36809005059 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 36809005060 DUF35 OB-fold domain; Region: DUF35; pfam01796 36809005061 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809005062 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809005063 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 36809005064 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809005065 active site 36809005066 catalytic site [active] 36809005067 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809005068 active site 2 [active] 36809005069 active site 1 [active] 36809005070 N-terminal half of MaoC dehydratase; Region: MaoC_dehydrat_N; pfam13452 36809005071 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809005072 active site 2 [active] 36809005073 active site 1 [active] 36809005074 enoyl-CoA hydratase; Provisional; Region: PRK06494 36809005075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809005076 substrate binding site [chemical binding]; other site 36809005077 oxyanion hole (OAH) forming residues; other site 36809005078 trimer interface [polypeptide binding]; other site 36809005079 TIGR03084 family protein; Region: TIGR03084 36809005080 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 36809005081 Wyosine base formation; Region: Wyosine_form; pfam08608 36809005082 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 36809005083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809005085 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809005086 CoA binding site [chemical binding]; other site 36809005087 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809005088 acyl-activating enzyme (AAE) consensus motif; other site 36809005089 active site 36809005090 AMP binding site [chemical binding]; other site 36809005091 CoA binding site [chemical binding]; other site 36809005092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809005093 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 36809005094 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809005095 active site 36809005096 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 36809005097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 36809005098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809005099 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 36809005100 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 36809005101 carboxyltransferase (CT) interaction site; other site 36809005102 biotinylation site [posttranslational modification]; other site 36809005103 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 36809005104 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809005105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005106 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 36809005107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005108 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809005109 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809005110 classical (c) SDRs; Region: SDR_c; cd05233 36809005111 NAD(P) binding site [chemical binding]; other site 36809005112 active site 36809005113 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809005114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809005115 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809005116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809005117 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809005118 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809005119 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809005120 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809005121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809005122 Cytochrome P450; Region: p450; cl12078 36809005123 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 36809005124 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 36809005125 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 36809005126 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 36809005127 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 36809005128 dimer interface [polypeptide binding]; other site 36809005129 acyl-activating enzyme (AAE) consensus motif; other site 36809005130 putative active site [active] 36809005131 AMP binding site [chemical binding]; other site 36809005132 putative CoA binding site [chemical binding]; other site 36809005133 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809005134 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809005135 active site 36809005136 NlpC/p60-like transpeptidase; Region: Transpep_BrtH; pfam14399 36809005137 putative active site [active] 36809005138 SCP-2 sterol transfer family; Region: SCP2; cl01225 36809005139 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 36809005140 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 36809005141 NAD binding site [chemical binding]; other site 36809005142 catalytic Zn binding site [ion binding]; other site 36809005143 substrate binding site [chemical binding]; other site 36809005144 structural Zn binding site [ion binding]; other site 36809005145 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809005146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809005147 active site 36809005148 Integrase core domain; Region: rve; pfam00665 36809005149 Integrase core domain; Region: rve_3; cl15866 36809005150 Transposase; Region: HTH_Tnp_1; cl17663 36809005151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 36809005152 putative transposase OrfB; Reviewed; Region: PHA02517 36809005153 Integrase core domain; Region: rve; pfam00665 36809005154 Integrase core domain; Region: rve_3; cl15866 36809005155 Putative nucleic acid-binding region; Region: Nucleic_acid_bd; pfam13820 36809005156 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 36809005157 active site 36809005158 nucleophile elbow; other site 36809005159 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 36809005160 active site 36809005161 NTP binding site [chemical binding]; other site 36809005162 metal binding triad [ion binding]; metal-binding site 36809005163 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 36809005164 ThiF family; Region: ThiF; pfam00899 36809005165 ATP binding site [chemical binding]; other site 36809005166 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 36809005167 Zn2+ binding site [ion binding]; other site 36809005168 Mg2+ binding site [ion binding]; other site 36809005169 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 36809005170 nudix motif; other site 36809005171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809005172 non-specific DNA binding site [nucleotide binding]; other site 36809005173 salt bridge; other site 36809005174 sequence-specific DNA binding site [nucleotide binding]; other site 36809005175 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 36809005176 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 36809005177 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 36809005178 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 36809005179 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 36809005180 catalytic residues [active] 36809005181 catalytic nucleophile [active] 36809005182 Recombinase; Region: Recombinase; pfam07508 36809005183 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 36809005184 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 36809005185 hypothetical protein; Provisional; Region: PRK07906 36809005186 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 36809005187 putative metal binding site [ion binding]; other site 36809005188 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 36809005189 substrate binding site [chemical binding]; other site 36809005190 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 36809005191 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 36809005192 quinone interaction residues [chemical binding]; other site 36809005193 active site 36809005194 catalytic residues [active] 36809005195 FMN binding site [chemical binding]; other site 36809005196 substrate binding site [chemical binding]; other site 36809005197 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 36809005198 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809005199 catalytic core [active] 36809005200 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 36809005201 conserved hypothetical protein; Region: TIGR03843 36809005202 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 36809005203 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 36809005204 active site 36809005205 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 36809005206 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 36809005207 active site 36809005208 HIGH motif; other site 36809005209 KMSKS motif; other site 36809005210 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 36809005211 putative tRNA binding surface [nucleotide binding]; other site 36809005212 short chain dehydrogenase; Provisional; Region: PRK05872 36809005213 classical (c) SDRs; Region: SDR_c; cd05233 36809005214 NAD(P) binding site [chemical binding]; other site 36809005215 active site 36809005216 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 36809005217 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809005218 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 36809005219 short chain dehydrogenase; Region: adh_short; pfam00106 36809005220 NADP binding site [chemical binding]; other site 36809005221 active site 36809005222 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 36809005223 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809005224 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 36809005225 active site 36809005226 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 36809005227 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809005228 Condensation domain; Region: Condensation; cl19241 36809005229 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809005230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809005231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809005232 acyl-activating enzyme (AAE) consensus motif; other site 36809005233 AMP binding site [chemical binding]; other site 36809005234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005235 Condensation domain; Region: Condensation; pfam00668 36809005236 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809005237 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005238 Condensation domain; Region: Condensation; pfam00668 36809005239 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809005240 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809005241 acyl-activating enzyme (AAE) consensus motif; other site 36809005242 AMP binding site [chemical binding]; other site 36809005243 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005244 Condensation domain; Region: Condensation; cl19241 36809005245 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809005246 Phosphopantetheine attachment site; Region: PP-binding; cl09936 36809005247 Condensation domain; Region: Condensation; cl19241 36809005248 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809005249 Nonribosomal peptide synthase; Region: NRPS; pfam08415 36809005250 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 36809005251 acyl-activating enzyme (AAE) consensus motif; other site 36809005252 AMP binding site [chemical binding]; other site 36809005253 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005254 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 36809005255 putative FMN binding site [chemical binding]; other site 36809005256 NADPH bind site [chemical binding]; other site 36809005257 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 36809005258 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 36809005259 phosphate binding site [ion binding]; other site 36809005260 Predicted membrane protein [Function unknown]; Region: COG2860 36809005261 UPF0126 domain; Region: UPF0126; pfam03458 36809005262 UPF0126 domain; Region: UPF0126; pfam03458 36809005263 PAC2 family; Region: PAC2; pfam09754 36809005264 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 36809005265 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 36809005266 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 36809005267 substrate binding pocket [chemical binding]; other site 36809005268 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 36809005269 B12 binding site [chemical binding]; other site 36809005270 cobalt ligand [ion binding]; other site 36809005271 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 36809005272 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 36809005273 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 36809005274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809005275 motif II; other site 36809005276 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 36809005277 homodimer interface [polypeptide binding]; other site 36809005278 putative metal binding site [ion binding]; other site 36809005279 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 36809005280 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 36809005281 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 36809005282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 36809005283 active site 36809005284 phosphorylation site [posttranslational modification] 36809005285 intermolecular recognition site; other site 36809005286 dimerization interface [polypeptide binding]; other site 36809005287 NADH dehydrogenase subunit A; Validated; Region: PRK07928 36809005288 NADH dehydrogenase subunit B; Validated; Region: PRK06411 36809005289 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 36809005290 NADH dehydrogenase subunit D; Validated; Region: PRK06075 36809005291 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 36809005292 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 36809005293 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 36809005294 putative dimer interface [polypeptide binding]; other site 36809005295 [2Fe-2S] cluster binding site [ion binding]; other site 36809005296 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 36809005297 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 36809005298 SLBB domain; Region: SLBB; pfam10531 36809005299 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 36809005300 NADH dehydrogenase subunit G; Validated; Region: PRK07860 36809005301 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809005302 catalytic loop [active] 36809005303 iron binding site [ion binding]; other site 36809005304 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 36809005305 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 36809005306 molybdopterin cofactor binding site; other site 36809005307 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 36809005308 molybdopterin cofactor binding site; other site 36809005309 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 36809005310 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 36809005311 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 36809005312 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 36809005313 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 36809005314 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 36809005315 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 36809005316 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 36809005317 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 36809005318 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 36809005319 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 36809005320 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 36809005321 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 36809005322 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 36809005323 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 36809005324 putative di-iron ligands [ion binding]; other site 36809005325 Permease; Region: Permease; cl00510 36809005326 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809005327 Cytochrome P450; Region: p450; cl12078 36809005328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809005330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 36809005331 MOSC domain; Region: MOSC; pfam03473 36809005332 3-alpha domain; Region: 3-alpha; pfam03475 36809005333 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 36809005334 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809005335 active site 2 [active] 36809005336 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 36809005337 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 36809005338 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809005339 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 36809005340 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 36809005341 homodimer interface [polypeptide binding]; other site 36809005342 putative substrate binding pocket [chemical binding]; other site 36809005343 diiron center [ion binding]; other site 36809005344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 36809005345 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 36809005346 ATP binding site [chemical binding]; other site 36809005347 putative Mg++ binding site [ion binding]; other site 36809005348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809005349 nucleotide binding region [chemical binding]; other site 36809005350 ATP-binding site [chemical binding]; other site 36809005351 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 36809005352 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 36809005353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809005354 S-adenosylmethionine binding site [chemical binding]; other site 36809005355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 36809005356 proteasome ATPase; Region: pup_AAA; TIGR03689 36809005357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809005358 Walker A motif; other site 36809005359 ATP binding site [chemical binding]; other site 36809005360 Walker B motif; other site 36809005361 arginine finger; other site 36809005362 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 36809005363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809005364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809005365 DNA binding residues [nucleotide binding] 36809005366 Putative zinc-finger; Region: zf-HC2; pfam13490 36809005367 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 36809005368 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 36809005369 PYR/PP interface [polypeptide binding]; other site 36809005370 dimer interface [polypeptide binding]; other site 36809005371 TPP binding site [chemical binding]; other site 36809005372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 36809005373 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 36809005374 TPP-binding site [chemical binding]; other site 36809005375 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 36809005376 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 36809005377 active site 36809005378 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 36809005379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809005381 homodimer interface [polypeptide binding]; other site 36809005382 catalytic residue [active] 36809005383 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 36809005384 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 36809005385 Pup-like protein; Region: Pup; pfam05639 36809005386 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 36809005387 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 36809005388 active site 36809005389 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 36809005390 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 36809005391 active site 36809005392 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 36809005393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809005394 dimer interface [polypeptide binding]; other site 36809005395 conserved gate region; other site 36809005396 putative PBP binding loops; other site 36809005397 ABC-ATPase subunit interface; other site 36809005398 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 36809005399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 36809005400 substrate binding pocket [chemical binding]; other site 36809005401 membrane-bound complex binding site; other site 36809005402 hinge residues; other site 36809005403 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 36809005404 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 36809005405 Walker A/P-loop; other site 36809005406 ATP binding site [chemical binding]; other site 36809005407 Q-loop/lid; other site 36809005408 ABC transporter signature motif; other site 36809005409 Walker B; other site 36809005410 D-loop; other site 36809005411 H-loop/switch region; other site 36809005412 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809005413 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 36809005414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809005415 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 36809005416 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 36809005417 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 36809005418 putative active site [active] 36809005419 Predicted transcriptional regulator [Transcription]; Region: COG2378 36809005420 WYL domain; Region: WYL; pfam13280 36809005421 Predicted transcriptional regulator [Transcription]; Region: COG2378 36809005422 WYL domain; Region: WYL; pfam13280 36809005423 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 36809005424 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 36809005425 DEAD-like helicases superfamily; Region: DEXDc; smart00487 36809005426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809005427 ATP binding site [chemical binding]; other site 36809005428 putative Mg++ binding site [ion binding]; other site 36809005429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809005430 nucleotide binding region [chemical binding]; other site 36809005431 ATP-binding site [chemical binding]; other site 36809005432 Ciliary protein causing Leber congenital amaurosis disease; Region: Lebercilin; pfam15619 36809005433 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 36809005434 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 36809005435 5'-3' exonuclease; Region: 53EXOc; smart00475 36809005436 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 36809005437 active site 36809005438 metal binding site 1 [ion binding]; metal-binding site 36809005439 putative 5' ssDNA interaction site; other site 36809005440 metal binding site 3; metal-binding site 36809005441 metal binding site 2 [ion binding]; metal-binding site 36809005442 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 36809005443 putative DNA binding site [nucleotide binding]; other site 36809005444 putative metal binding site [ion binding]; other site 36809005445 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 36809005446 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 36809005447 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 36809005448 active site 36809005449 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 36809005450 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809005451 classical (c) SDRs; Region: SDR_c; cd05233 36809005452 NAD(P) binding site [chemical binding]; other site 36809005453 active site 36809005454 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 36809005455 active site 36809005456 putative homodimer interface [polypeptide binding]; other site 36809005457 SAM binding site [chemical binding]; other site 36809005458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809005459 S-adenosylmethionine binding site [chemical binding]; other site 36809005460 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 36809005461 active site 36809005462 SAM binding site [chemical binding]; other site 36809005463 homodimer interface [polypeptide binding]; other site 36809005464 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 36809005465 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 36809005466 active site 36809005467 SAM binding site [chemical binding]; other site 36809005468 homodimer interface [polypeptide binding]; other site 36809005469 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 36809005470 active site 36809005471 SAM binding site [chemical binding]; other site 36809005472 homodimer interface [polypeptide binding]; other site 36809005473 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 36809005474 precorrin-3B synthase; Region: CobG; TIGR02435 36809005475 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 36809005476 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 36809005477 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809005478 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 36809005479 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 36809005480 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 36809005481 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 36809005482 active site 36809005483 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 36809005484 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 36809005485 putative active site [active] 36809005486 catalytic triad [active] 36809005487 putative dimer interface [polypeptide binding]; other site 36809005488 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 36809005489 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 36809005490 Ligand binding site; other site 36809005491 Putative Catalytic site; other site 36809005492 DXD motif; other site 36809005493 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 36809005494 Leucine carboxyl methyltransferase; Region: LCM; cl01306 36809005495 Transport protein; Region: actII; TIGR00833 36809005496 MMPL family; Region: MMPL; pfam03176 36809005497 MMPL family; Region: MMPL; pfam03176 36809005498 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809005499 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 36809005500 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809005501 active site 36809005502 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809005503 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 36809005504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809005505 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 36809005506 Enoylreductase; Region: PKS_ER; smart00829 36809005507 NAD(P) binding site [chemical binding]; other site 36809005508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809005509 short chain dehydrogenase; Region: adh_short; pfam00106 36809005510 NAD(P) binding site [chemical binding]; other site 36809005511 active site 36809005512 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005513 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809005514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809005515 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 36809005516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809005517 dimer interface [polypeptide binding]; other site 36809005518 conserved gate region; other site 36809005519 putative PBP binding loops; other site 36809005520 ABC-ATPase subunit interface; other site 36809005521 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 36809005522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809005523 Walker A/P-loop; other site 36809005524 ATP binding site [chemical binding]; other site 36809005525 Q-loop/lid; other site 36809005526 ABC transporter signature motif; other site 36809005527 Walker B; other site 36809005528 D-loop; other site 36809005529 H-loop/switch region; other site 36809005530 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 36809005531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 36809005532 substrate binding pocket [chemical binding]; other site 36809005533 membrane-bound complex binding site; other site 36809005534 hinge residues; other site 36809005535 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 36809005536 active site 36809005537 dimer interface [polypeptide binding]; other site 36809005538 non-prolyl cis peptide bond; other site 36809005539 insertion regions; other site 36809005540 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 36809005541 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 36809005542 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 36809005543 TspO/MBR family; Region: TspO_MBR; pfam03073 36809005544 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 36809005545 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 36809005546 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 36809005547 active site 36809005548 catalytic residues [active] 36809005549 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 36809005550 EspG family; Region: ESX-1_EspG; pfam14011 36809005551 Proteins of 100 residues with WXG; Region: WXG100; cl02005 36809005552 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 36809005553 PPE family; Region: PPE; pfam00823 36809005554 PE family; Region: PE; pfam00934 36809005555 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 36809005556 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 36809005557 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 36809005558 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 36809005559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 36809005560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 36809005561 Walker A/P-loop; other site 36809005562 ATP binding site [chemical binding]; other site 36809005563 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 36809005564 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 36809005565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 36809005566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809005567 Walker A motif; other site 36809005568 ATP binding site [chemical binding]; other site 36809005569 Walker B motif; other site 36809005570 arginine finger; other site 36809005571 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 36809005572 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 36809005573 FAD binding pocket [chemical binding]; other site 36809005574 FAD binding motif [chemical binding]; other site 36809005575 phosphate binding motif [ion binding]; other site 36809005576 NAD binding pocket [chemical binding]; other site 36809005577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809005578 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 36809005579 hypothetical protein; Provisional; Region: PRK07538 36809005580 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 36809005581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809005582 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 36809005583 putative dimerization interface [polypeptide binding]; other site 36809005584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809005585 DNA-binding site [nucleotide binding]; DNA binding site 36809005586 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 36809005587 UTRA domain; Region: UTRA; pfam07702 36809005588 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 36809005589 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 36809005590 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 36809005591 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 36809005592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809005593 dimer interface [polypeptide binding]; other site 36809005594 conserved gate region; other site 36809005595 putative PBP binding loops; other site 36809005596 ABC-ATPase subunit interface; other site 36809005597 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 36809005598 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 36809005599 Walker A/P-loop; other site 36809005600 ATP binding site [chemical binding]; other site 36809005601 Q-loop/lid; other site 36809005602 ABC transporter signature motif; other site 36809005603 Walker B; other site 36809005604 D-loop; other site 36809005605 H-loop/switch region; other site 36809005606 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 36809005607 L-aspartate oxidase; Provisional; Region: PRK06175 36809005608 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 36809005609 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 36809005610 protein binding surface [polypeptide binding]; other site 36809005611 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 36809005612 protein binding surface [polypeptide binding]; other site 36809005613 salicylate synthase MbtI; Reviewed; Region: PRK07912 36809005614 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 36809005615 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 36809005616 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809005617 DNA binding residues [nucleotide binding] 36809005618 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 36809005619 catalytic triad [active] 36809005620 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 36809005621 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 36809005622 acyl-activating enzyme (AAE) consensus motif; other site 36809005623 active site 36809005624 AMP binding site [chemical binding]; other site 36809005625 substrate binding site [chemical binding]; other site 36809005626 Condensation domain; Region: Condensation; cl19241 36809005627 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809005628 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809005629 acyl-activating enzyme (AAE) consensus motif; other site 36809005630 AMP binding site [chemical binding]; other site 36809005631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005632 Condensation domain; Region: Condensation; cl19241 36809005633 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809005634 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 36809005635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809005636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 36809005637 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809005638 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 36809005639 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 36809005640 PPE family; Region: PPE; pfam00823 36809005641 Condensation domain; Region: Condensation; pfam00668 36809005642 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809005643 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809005644 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809005645 acyl-activating enzyme (AAE) consensus motif; other site 36809005646 AMP binding site [chemical binding]; other site 36809005647 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005648 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 36809005649 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809005650 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809005651 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 36809005652 active site 36809005653 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809005654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005655 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809005656 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 36809005657 active site 36809005658 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809005659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809005660 S-adenosylmethionine binding site [chemical binding]; other site 36809005661 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005662 Condensation domain; Region: Condensation; pfam00668 36809005663 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809005664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809005665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809005666 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 36809005667 acyl-activating enzyme (AAE) consensus motif; other site 36809005668 AMP binding site [chemical binding]; other site 36809005669 active site 36809005670 CoA binding site [chemical binding]; other site 36809005671 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 36809005672 short chain dehydrogenase; Region: adh_short; pfam00106 36809005673 putative NADP binding site [chemical binding]; other site 36809005674 active site 36809005675 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809005676 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 36809005677 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 36809005678 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 36809005679 active site 36809005680 substrate binding site [chemical binding]; other site 36809005681 cosubstrate binding site; other site 36809005682 catalytic site [active] 36809005683 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 36809005684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 36809005685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809005686 Walker A/P-loop; other site 36809005687 ATP binding site [chemical binding]; other site 36809005688 Q-loop/lid; other site 36809005689 ABC transporter signature motif; other site 36809005690 Walker B; other site 36809005691 D-loop; other site 36809005692 H-loop/switch region; other site 36809005693 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 36809005694 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 36809005695 FAD binding pocket [chemical binding]; other site 36809005696 FAD binding motif [chemical binding]; other site 36809005697 phosphate binding motif [ion binding]; other site 36809005698 NAD binding pocket [chemical binding]; other site 36809005699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 36809005700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 36809005701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809005702 Walker A/P-loop; other site 36809005703 ATP binding site [chemical binding]; other site 36809005704 Q-loop/lid; other site 36809005705 ABC transporter signature motif; other site 36809005706 Walker B; other site 36809005707 D-loop; other site 36809005708 H-loop/switch region; other site 36809005709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809005710 metabolite-proton symporter; Region: 2A0106; TIGR00883 36809005711 putative substrate translocation pore; other site 36809005712 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 36809005713 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 36809005714 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809005715 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809005716 inhibitor-cofactor binding pocket; inhibition site 36809005717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809005718 catalytic residue [active] 36809005719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809005720 Coenzyme A binding pocket [chemical binding]; other site 36809005721 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 36809005722 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 36809005723 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 36809005724 DNA binding residues [nucleotide binding] 36809005725 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 36809005726 Protein of unknown function (DUF461); Region: DUF461; pfam04314 36809005727 Transcriptional regulators [Transcription]; Region: FadR; COG2186 36809005728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809005729 DNA-binding site [nucleotide binding]; DNA binding site 36809005730 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 36809005731 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 36809005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809005733 putative substrate translocation pore; other site 36809005734 DoxX-like family; Region: DoxX_2; pfam13564 36809005735 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 36809005736 MMPL family; Region: MMPL; cl14618 36809005737 MMPL family; Region: MMPL; cl14618 36809005738 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 36809005739 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 36809005740 NAD(P) binding site [chemical binding]; other site 36809005741 catalytic residues [active] 36809005742 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809005743 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809005744 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809005745 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809005746 inhibitor-cofactor binding pocket; inhibition site 36809005747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809005748 catalytic residue [active] 36809005749 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 36809005750 putative hydrophobic ligand binding site [chemical binding]; other site 36809005751 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 36809005752 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 36809005753 FAD dependent oxidoreductase; Region: DAO; pfam01266 36809005754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809005755 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 36809005756 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 36809005757 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 36809005758 Zn2+ binding site [ion binding]; other site 36809005759 Mg2+ binding site [ion binding]; other site 36809005760 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809005761 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809005762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809005764 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 36809005765 putative hydrophobic ligand binding site [chemical binding]; other site 36809005766 protein interface [polypeptide binding]; other site 36809005767 gate; other site 36809005768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809005769 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809005770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809005771 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809005772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809005773 Protease prsW family; Region: PrsW-protease; pfam13367 36809005774 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 36809005775 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 36809005776 RNA binding site [nucleotide binding]; other site 36809005777 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 36809005778 RNA binding site [nucleotide binding]; other site 36809005779 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 36809005780 RNA binding site [nucleotide binding]; other site 36809005781 S1 RNA binding domain; Region: S1; pfam00575 36809005782 RNA binding site [nucleotide binding]; other site 36809005783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809005784 S-adenosylmethionine binding site [chemical binding]; other site 36809005785 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 36809005786 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 36809005787 CoA-binding site [chemical binding]; other site 36809005788 ATP-binding [chemical binding]; other site 36809005789 GrpB protein; Region: GrpB; pfam04229 36809005790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809005792 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809005793 Transport protein; Region: actII; TIGR00833 36809005794 MMPL family; Region: MMPL; pfam03176 36809005795 MMPL family; Region: MMPL; pfam03176 36809005796 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809005797 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 36809005798 MMPL family; Region: MMPL; pfam03176 36809005799 MMPL family; Region: MMPL; pfam03176 36809005800 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 36809005801 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 36809005802 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 36809005803 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 36809005804 Protein of unknown function (DUF402); Region: DUF402; cl00979 36809005805 excinuclease ABC subunit B; Provisional; Region: PRK05298 36809005806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809005807 ATP binding site [chemical binding]; other site 36809005808 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809005809 nucleotide binding region [chemical binding]; other site 36809005810 ATP-binding site [chemical binding]; other site 36809005811 Ultra-violet resistance protein B; Region: UvrB; pfam12344 36809005812 UvrB/uvrC motif; Region: UVR; pfam02151 36809005813 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 36809005814 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 36809005815 DNA binding residues [nucleotide binding] 36809005816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809005817 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 36809005818 putative substrate translocation pore; other site 36809005819 hypothetical protein; Provisional; Region: PRK09133 36809005820 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 36809005821 putative metal binding site [ion binding]; other site 36809005822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809005823 Ligand Binding Site [chemical binding]; other site 36809005824 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 36809005825 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 36809005826 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 36809005827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 36809005828 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 36809005829 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 36809005830 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 36809005831 putative AMP binding site [chemical binding]; other site 36809005832 putative active site [active] 36809005833 acyl-activating enzyme (AAE) consensus motif; other site 36809005834 putative CoA binding site [chemical binding]; other site 36809005835 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 36809005836 Protein of unknown function (DUF418); Region: DUF418; cl12135 36809005837 Putative esterase; Region: Esterase; pfam00756 36809005838 Protein of unknown function (DUF585); Region: DUF585; pfam04522 36809005839 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809005840 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 36809005841 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 36809005842 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 36809005843 dimer interface [polypeptide binding]; other site 36809005844 putative anticodon binding site; other site 36809005845 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 36809005846 motif 1; other site 36809005847 dimer interface [polypeptide binding]; other site 36809005848 active site 36809005849 motif 2; other site 36809005850 motif 3; other site 36809005851 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 36809005852 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 36809005853 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 36809005854 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 36809005855 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 36809005856 23S rRNA binding site [nucleotide binding]; other site 36809005857 L21 binding site [polypeptide binding]; other site 36809005858 L13 binding site [polypeptide binding]; other site 36809005859 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 36809005860 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 36809005861 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 36809005862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809005863 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 36809005864 NAD(P) binding site [chemical binding]; other site 36809005865 active site 36809005866 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 36809005867 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 36809005868 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 36809005869 MspA; Region: MspA; pfam09203 36809005870 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 36809005871 cyclase homology domain; Region: CHD; cd07302 36809005872 nucleotidyl binding site; other site 36809005873 metal binding site [ion binding]; metal-binding site 36809005874 dimer interface [polypeptide binding]; other site 36809005875 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 36809005876 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 36809005877 active site 36809005878 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 36809005879 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 36809005880 AlkA N-terminal domain; Region: AlkA_N; smart01009 36809005881 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 36809005882 HhH-GPD superfamily base excision DNA repair protein; Region: HhH-GPD; pfam00730 36809005883 minor groove reading motif; other site 36809005884 helix-hairpin-helix signature motif; other site 36809005885 substrate binding pocket [chemical binding]; other site 36809005886 active site 36809005887 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 36809005888 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 36809005889 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 36809005890 dimer interface [polypeptide binding]; other site 36809005891 motif 1; other site 36809005892 active site 36809005893 motif 2; other site 36809005894 motif 3; other site 36809005895 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 36809005896 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 36809005897 putative tRNA-binding site [nucleotide binding]; other site 36809005898 B3/4 domain; Region: B3_4; pfam03483 36809005899 tRNA synthetase B5 domain; Region: B5; smart00874 36809005900 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 36809005901 dimer interface [polypeptide binding]; other site 36809005902 motif 1; other site 36809005903 motif 3; other site 36809005904 motif 2; other site 36809005905 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 36809005906 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 36809005907 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 36809005908 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 36809005909 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 36809005910 heterotetramer interface [polypeptide binding]; other site 36809005911 active site pocket [active] 36809005912 cleavage site 36809005913 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 36809005914 feedback inhibition sensing region; other site 36809005915 homohexameric interface [polypeptide binding]; other site 36809005916 nucleotide binding site [chemical binding]; other site 36809005917 N-acetyl-L-glutamate binding site [chemical binding]; other site 36809005918 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809005919 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809005920 inhibitor-cofactor binding pocket; inhibition site 36809005921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809005922 catalytic residue [active] 36809005923 ornithine carbamoyltransferase; Provisional; Region: PRK00779 36809005924 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 36809005925 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 36809005926 arginine repressor; Provisional; Region: PRK03341 36809005927 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 36809005928 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 36809005929 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 36809005930 ANP binding site [chemical binding]; other site 36809005931 Substrate Binding Site II [chemical binding]; other site 36809005932 Substrate Binding Site I [chemical binding]; other site 36809005933 argininosuccinate lyase; Provisional; Region: PRK00855 36809005934 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 36809005935 active sites [active] 36809005936 tetramer interface [polypeptide binding]; other site 36809005937 aspartate kinase, monofunctional class; Region: asp_kin_monofn; TIGR00656 36809005938 Competence-damaged protein; Region: CinA; cl00666 36809005939 acyl-CoA synthetase; Validated; Region: PRK07868 36809005940 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 36809005941 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809005942 acyl-activating enzyme (AAE) consensus motif; other site 36809005943 AMP binding site [chemical binding]; other site 36809005944 active site 36809005945 CoA binding site [chemical binding]; other site 36809005946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809005947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809005948 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 36809005949 active site 36809005950 DNA binding site [nucleotide binding] 36809005951 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 36809005952 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 36809005953 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 36809005954 active site 36809005955 HIGH motif; other site 36809005956 dimer interface [polypeptide binding]; other site 36809005957 KMSKS motif; other site 36809005958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 36809005959 RNA binding surface [nucleotide binding]; other site 36809005960 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 36809005961 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809005962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809005963 Walker A/P-loop; other site 36809005964 ATP binding site [chemical binding]; other site 36809005965 Q-loop/lid; other site 36809005966 ABC transporter signature motif; other site 36809005967 Walker B; other site 36809005968 D-loop; other site 36809005969 H-loop/switch region; other site 36809005970 transcription termination factor Rho; Provisional; Region: PRK12678 36809005971 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 36809005972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809005973 active site 36809005974 motif I; other site 36809005975 motif II; other site 36809005976 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 36809005977 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 36809005978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 36809005979 RNA binding surface [nucleotide binding]; other site 36809005980 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 36809005981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809005982 S-adenosylmethionine binding site [chemical binding]; other site 36809005983 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 36809005984 DNA repair protein RecN; Region: recN; TIGR00634 36809005985 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 36809005986 Walker A/P-loop; other site 36809005987 ATP binding site [chemical binding]; other site 36809005988 Q-loop/lid; other site 36809005989 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 36809005990 ABC transporter signature motif; other site 36809005991 Walker B; other site 36809005992 D-loop; other site 36809005993 H-loop/switch region; other site 36809005994 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 36809005995 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 36809005996 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 36809005997 CTP synthetase; Validated; Region: pyrG; PRK05380 36809005998 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 36809005999 Catalytic site [active] 36809006000 active site 36809006001 UTP binding site [chemical binding]; other site 36809006002 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 36809006003 active site 36809006004 putative oxyanion hole; other site 36809006005 catalytic triad [active] 36809006006 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 36809006007 dimer interface [polypeptide binding]; other site 36809006008 active site 36809006009 ADP-ribose binding site [chemical binding]; other site 36809006010 nudix motif; other site 36809006011 metal binding site [ion binding]; metal-binding site 36809006012 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 36809006013 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 36809006014 active site 36809006015 Int/Topo IB signature motif; other site 36809006016 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 36809006017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 36809006018 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809006019 P-loop; other site 36809006020 Magnesium ion binding site [ion binding]; other site 36809006021 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 36809006022 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 36809006023 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 36809006024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 36809006025 RNA binding surface [nucleotide binding]; other site 36809006026 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 36809006027 active site 36809006028 cytidylate kinase; Provisional; Region: cmk; PRK00023 36809006029 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 36809006030 CMP-binding site; other site 36809006031 The sites determining sugar specificity; other site 36809006032 GTP-binding protein Der; Reviewed; Region: PRK03003 36809006033 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 36809006034 G1 box; other site 36809006035 GTP/Mg2+ binding site [chemical binding]; other site 36809006036 Switch I region; other site 36809006037 G2 box; other site 36809006038 Switch II region; other site 36809006039 G3 box; other site 36809006040 G4 box; other site 36809006041 G5 box; other site 36809006042 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 36809006043 G1 box; other site 36809006044 GTP/Mg2+ binding site [chemical binding]; other site 36809006045 Switch I region; other site 36809006046 G2 box; other site 36809006047 G3 box; other site 36809006048 Switch II region; other site 36809006049 G4 box; other site 36809006050 G5 box; other site 36809006051 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 36809006052 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 36809006053 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 36809006054 dimerization interface [polypeptide binding]; other site 36809006055 mannose binding site [chemical binding]; other site 36809006056 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 36809006057 Domain of unknown function (DUF222); Region: DUF222; pfam02720 36809006058 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809006059 active site 36809006060 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 36809006061 tetracycline repressor protein TetR; Provisional; Region: PRK13756 36809006062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006063 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 36809006064 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 36809006065 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 36809006066 FMN-binding pocket [chemical binding]; other site 36809006067 flavin binding motif; other site 36809006068 phosphate binding motif [ion binding]; other site 36809006069 beta-alpha-beta structure motif; other site 36809006070 NAD binding pocket [chemical binding]; other site 36809006071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809006072 catalytic loop [active] 36809006073 iron binding site [ion binding]; other site 36809006074 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809006075 A new structural DNA glycosylase; Region: AlkD_like; cd06561 36809006076 active site 36809006077 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 36809006078 Phosphotransferase enzyme family; Region: APH; pfam01636 36809006079 active site 36809006080 ATP binding site [chemical binding]; other site 36809006081 antibiotic binding site [chemical binding]; other site 36809006082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809006083 dimerization interface [polypeptide binding]; other site 36809006084 putative DNA binding site [nucleotide binding]; other site 36809006085 putative Zn2+ binding site [ion binding]; other site 36809006086 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 36809006087 putative hydrophobic ligand binding site [chemical binding]; other site 36809006088 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 36809006089 dimer interface [polypeptide binding]; other site 36809006090 substrate binding site [chemical binding]; other site 36809006091 metal binding site [ion binding]; metal-binding site 36809006092 hypothetical protein; Validated; Region: PRK07121 36809006093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006094 Mediator of RNA polymerase II transcription complex subunit 8; Region: Med8; pfam10232 36809006095 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809006096 active site 36809006097 ATP binding site [chemical binding]; other site 36809006098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006100 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809006101 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 36809006102 active site 36809006103 ATP binding site [chemical binding]; other site 36809006104 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 36809006105 hydrophobic ligand binding site; other site 36809006106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809006107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809006108 active site 36809006109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809006110 Coenzyme A binding pocket [chemical binding]; other site 36809006111 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 36809006112 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 36809006113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809006114 nucleotide binding region [chemical binding]; other site 36809006115 ATP-binding site [chemical binding]; other site 36809006116 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 36809006117 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 36809006118 Bacterial protein of unknown function (DUF881); Region: DUF881; cl19849 36809006119 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 36809006120 Bacterial protein of unknown function (DUF881); Region: DUF881; cl19849 36809006121 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 36809006122 lipoyl attachment site [posttranslational modification]; other site 36809006123 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 36809006124 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 36809006125 phosphopeptide binding site; other site 36809006126 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 36809006127 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809006128 DNA binding residues [nucleotide binding] 36809006129 Bifunctional nuclease; Region: DNase-RNase; pfam02577 36809006130 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 36809006131 DNA binding residues [nucleotide binding] 36809006132 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809006133 putative dimer interface [polypeptide binding]; other site 36809006134 glycine dehydrogenase; Provisional; Region: PRK05367 36809006135 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 36809006136 tetramer interface [polypeptide binding]; other site 36809006137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809006138 catalytic residue [active] 36809006139 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 36809006140 tetramer interface [polypeptide binding]; other site 36809006141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809006142 catalytic residue [active] 36809006143 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 36809006144 metal ion-dependent adhesion site (MIDAS); other site 36809006145 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 36809006146 active site 36809006147 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 36809006148 Domain of unknown function DUF21; Region: DUF21; pfam01595 36809006149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 36809006150 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 36809006151 Domain of unknown function DUF21; Region: DUF21; pfam01595 36809006152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 36809006153 Transporter associated domain; Region: CorC_HlyC; smart01091 36809006154 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 36809006155 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 36809006156 active site 36809006157 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 36809006158 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 36809006159 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 36809006160 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 36809006161 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 36809006162 Predicted transcriptional regulator [Transcription]; Region: COG3682 36809006163 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809006164 CoenzymeA binding site [chemical binding]; other site 36809006165 subunit interaction site [polypeptide binding]; other site 36809006166 PHB binding site; other site 36809006167 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809006168 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809006169 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809006170 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809006171 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 36809006172 alpha-gamma subunit interface [polypeptide binding]; other site 36809006173 beta-gamma subunit interface [polypeptide binding]; other site 36809006174 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 36809006175 gamma-beta subunit interface [polypeptide binding]; other site 36809006176 alpha-beta subunit interface [polypeptide binding]; other site 36809006177 urease subunit alpha; Reviewed; Region: ureC; PRK13206 36809006178 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 36809006179 subunit interactions [polypeptide binding]; other site 36809006180 active site 36809006181 flap region; other site 36809006182 UreF; Region: UreF; cl19817 36809006183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 36809006184 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809006185 Walker A/P-loop; other site 36809006186 ATP binding site [chemical binding]; other site 36809006187 Q-loop/lid; other site 36809006188 Walker B; other site 36809006189 D-loop; other site 36809006190 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 36809006191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809006192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809006193 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809006194 TIGR03086 family protein; Region: TIGR03086 36809006195 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 36809006196 short chain dehydrogenase; Provisional; Region: PRK05884 36809006197 short chain dehydrogenase; Provisional; Region: PRK12939 36809006198 NAD(P) binding site [chemical binding]; other site 36809006199 active site 36809006200 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 36809006201 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 36809006202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809006203 dimer interface [polypeptide binding]; other site 36809006204 conserved gate region; other site 36809006205 putative PBP binding loops; other site 36809006206 ABC-ATPase subunit interface; other site 36809006207 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 36809006208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809006209 Walker A/P-loop; other site 36809006210 ATP binding site [chemical binding]; other site 36809006211 Q-loop/lid; other site 36809006212 ABC transporter signature motif; other site 36809006213 Walker B; other site 36809006214 D-loop; other site 36809006215 H-loop/switch region; other site 36809006216 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 36809006217 Predicted membrane protein [Function unknown]; Region: COG2261 36809006218 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 36809006219 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 36809006220 molybdopterin cofactor binding site; other site 36809006221 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 36809006222 molybdopterin cofactor binding site; other site 36809006223 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 36809006224 Flavodoxin; Region: Flavodoxin_1; pfam00258 36809006225 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 36809006226 FAD binding pocket [chemical binding]; other site 36809006227 FAD binding motif [chemical binding]; other site 36809006228 catalytic residues [active] 36809006229 NAD binding pocket [chemical binding]; other site 36809006230 phosphate binding motif [ion binding]; other site 36809006231 beta-alpha-beta structure motif; other site 36809006232 CrcB-like protein; Region: CRCB; pfam02537 36809006233 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 36809006234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809006235 Ligand Binding Site [chemical binding]; other site 36809006236 competence damage-inducible protein A; Provisional; Region: PRK00549 36809006237 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 36809006238 putative MPT binding site; other site 36809006239 Competence-damaged protein; Region: CinA; pfam02464 36809006240 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 36809006241 Zn2+ binding site [ion binding]; other site 36809006242 Mg2+ binding site [ion binding]; other site 36809006243 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 36809006244 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 36809006245 conserved cys residue [active] 36809006246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809006247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809006248 Pirin-related protein [General function prediction only]; Region: COG1741 36809006249 Pirin; Region: Pirin; pfam02678 36809006250 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 36809006251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006253 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 36809006254 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809006255 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809006256 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 36809006257 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809006258 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 36809006259 active site 36809006260 catalytic triad [active] 36809006261 oxyanion hole [active] 36809006262 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 36809006263 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 36809006264 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 36809006265 FAD binding domain; Region: FAD_binding_4; pfam01565 36809006266 Berberine and berberine like; Region: BBE; pfam08031 36809006267 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809006268 hydrophobic ligand binding site; other site 36809006269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006271 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 36809006272 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809006273 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809006274 active site 36809006275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809006276 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 36809006277 Walker A/P-loop; other site 36809006278 ATP binding site [chemical binding]; other site 36809006279 Q-loop/lid; other site 36809006280 ABC transporter signature motif; other site 36809006281 Walker B; other site 36809006282 D-loop; other site 36809006283 H-loop/switch region; other site 36809006284 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 36809006285 NMT1-like family; Region: NMT1_2; pfam13379 36809006286 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 36809006287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809006288 dimer interface [polypeptide binding]; other site 36809006289 conserved gate region; other site 36809006290 putative PBP binding loops; other site 36809006291 ABC-ATPase subunit interface; other site 36809006292 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 36809006293 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809006294 substrate binding site [chemical binding]; other site 36809006295 oxyanion hole (OAH) forming residues; other site 36809006296 trimer interface [polypeptide binding]; other site 36809006297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006299 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 36809006300 heme bH binding site [chemical binding]; other site 36809006301 Qi binding site; other site 36809006302 intrachain domain interface; other site 36809006303 heme bL binding site [chemical binding]; other site 36809006304 interchain domain interface [polypeptide binding]; other site 36809006305 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 36809006306 Qo binding site; other site 36809006307 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 36809006308 active site 36809006309 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 36809006310 RNAase interaction site [polypeptide binding]; other site 36809006311 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 36809006312 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 36809006313 dimer interface [polypeptide binding]; other site 36809006314 active site 36809006315 heme binding site [chemical binding]; other site 36809006316 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 36809006317 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 36809006318 metal binding site 2 [ion binding]; metal-binding site 36809006319 putative DNA binding helix; other site 36809006320 metal binding site 1 [ion binding]; metal-binding site 36809006321 dimer interface [polypeptide binding]; other site 36809006322 structural Zn2+ binding site [ion binding]; other site 36809006323 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809006324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809006325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 36809006326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809006327 Coenzyme A binding pocket [chemical binding]; other site 36809006328 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 36809006329 NlpC/P60 family; Region: NLPC_P60; pfam00877 36809006330 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 36809006331 putative hydrophobic ligand binding site [chemical binding]; other site 36809006332 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 36809006333 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809006334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809006335 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 36809006336 putative hydrophobic ligand binding site [chemical binding]; other site 36809006337 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809006338 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 36809006339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809006340 metabolite-proton symporter; Region: 2A0106; TIGR00883 36809006341 putative substrate translocation pore; other site 36809006342 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 36809006343 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 36809006344 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 36809006345 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 36809006346 Flavodoxin; Region: Flavodoxin_1; pfam00258 36809006347 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 36809006348 FAD binding pocket [chemical binding]; other site 36809006349 FAD binding motif [chemical binding]; other site 36809006350 catalytic residues [active] 36809006351 NAD binding pocket [chemical binding]; other site 36809006352 phosphate binding motif [ion binding]; other site 36809006353 beta-alpha-beta structure motif; other site 36809006354 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 36809006355 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 36809006356 active site 36809006357 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 36809006358 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 36809006359 active site 36809006360 FMN binding site [chemical binding]; other site 36809006361 substrate binding site [chemical binding]; other site 36809006362 3Fe-4S cluster binding site [ion binding]; other site 36809006363 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 36809006364 domain_subunit interface; other site 36809006365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809006366 Ligand Binding Site [chemical binding]; other site 36809006367 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809006368 Ligand Binding Site [chemical binding]; other site 36809006369 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 36809006370 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 36809006371 Flavodoxin; Region: Flavodoxin_1; pfam00258 36809006372 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 36809006373 FAD binding pocket [chemical binding]; other site 36809006374 FAD binding motif [chemical binding]; other site 36809006375 catalytic residues [active] 36809006376 NAD binding pocket [chemical binding]; other site 36809006377 phosphate binding motif [ion binding]; other site 36809006378 beta-alpha-beta structure motif; other site 36809006379 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 36809006380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006381 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 36809006382 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809006383 active site 36809006384 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 36809006385 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 36809006386 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809006387 active site 36809006388 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 36809006389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 36809006390 nucleotide binding site [chemical binding]; other site 36809006391 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809006392 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809006393 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 36809006394 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 36809006395 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 36809006396 active site 36809006397 DNA binding site [nucleotide binding] 36809006398 Int/Topo IB signature motif; other site 36809006399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006400 FAD dependent oxidoreductase; Region: DAO; pfam01266 36809006401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006402 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 36809006403 iron-sulfur cluster [ion binding]; other site 36809006404 [2Fe-2S] cluster binding site [ion binding]; other site 36809006405 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 36809006406 putative phosphoketolase; Provisional; Region: PRK05261 36809006407 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 36809006408 TPP-binding site; other site 36809006409 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 36809006410 XFP C-terminal domain; Region: XFP_C; pfam09363 36809006411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 36809006412 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 36809006413 ligand binding site [chemical binding]; other site 36809006414 flexible hinge region; other site 36809006415 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 36809006416 putative switch regulator; other site 36809006417 non-specific DNA interactions [nucleotide binding]; other site 36809006418 DNA binding site [nucleotide binding] 36809006419 sequence specific DNA binding site [nucleotide binding]; other site 36809006420 putative cAMP binding site [chemical binding]; other site 36809006421 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 36809006422 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 36809006423 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 36809006424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809006425 S-adenosylmethionine binding site [chemical binding]; other site 36809006426 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 36809006427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809006428 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 36809006429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809006430 DNA binding residues [nucleotide binding] 36809006431 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 36809006432 anti sigma factor interaction site; other site 36809006433 regulatory phosphorylation site [posttranslational modification]; other site 36809006434 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 36809006435 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 36809006436 active site 36809006437 metal binding site [ion binding]; metal-binding site 36809006438 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 36809006439 Low affinity iron permease; Region: Iron_permease; cl12096 36809006440 Low affinity iron permease; Region: Iron_permease; cl12096 36809006441 CsbD-like; Region: CsbD; pfam05532 36809006442 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 36809006443 PAS fold; Region: PAS_3; pfam08447 36809006444 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 36809006445 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 36809006446 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 36809006447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809006448 catalytic residue [active] 36809006449 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 36809006450 PhoU domain; Region: PhoU; pfam01895 36809006451 LGFP repeat; Region: LGFP; pfam08310 36809006452 ChaB; Region: ChaB; pfam06150 36809006453 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 36809006454 hydroperoxidase II; Provisional; Region: katE; PRK11249 36809006455 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 36809006456 heme binding pocket [chemical binding]; other site 36809006457 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 36809006458 domain interactions; other site 36809006459 GAF domain; Region: GAF_2; pfam13185 36809006460 ANTAR domain; Region: ANTAR; pfam03861 36809006461 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 36809006462 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809006463 thiamine pyrophosphate protein; Provisional; Region: PRK08273 36809006464 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 36809006465 PYR/PP interface [polypeptide binding]; other site 36809006466 tetramer interface [polypeptide binding]; other site 36809006467 dimer interface [polypeptide binding]; other site 36809006468 TPP binding site [chemical binding]; other site 36809006469 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 36809006470 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 36809006471 TPP-binding site [chemical binding]; other site 36809006472 Secretory lipase; Region: LIP; pfam03583 36809006473 acyl-CoA synthetase; Validated; Region: PRK07788 36809006474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809006475 AMP binding site [chemical binding]; other site 36809006476 active site 36809006477 acyl-activating enzyme (AAE) consensus motif; other site 36809006478 CoA binding site [chemical binding]; other site 36809006479 short chain dehydrogenase; Provisional; Region: PRK07825 36809006480 classical (c) SDRs; Region: SDR_c; cd05233 36809006481 NAD(P) binding site [chemical binding]; other site 36809006482 active site 36809006483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006485 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809006486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006487 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006488 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 36809006489 Amidinotransferase; Region: Amidinotransf; cl19186 36809006490 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 36809006491 active site 36809006492 catalytic triad [active] 36809006493 dimer interface [polypeptide binding]; other site 36809006494 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 36809006495 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 36809006496 active site 36809006497 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 36809006498 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809006499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809006500 S-adenosylmethionine binding site [chemical binding]; other site 36809006501 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 36809006502 homodimer interface [polypeptide binding]; other site 36809006503 putative substrate binding pocket [chemical binding]; other site 36809006504 diiron center [ion binding]; other site 36809006505 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809006506 Cellulose binding domain; Region: CBM_2; pfam00553 36809006507 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 36809006508 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 36809006509 catalytic triad [active] 36809006510 conserved cis-peptide bond; other site 36809006511 carboxylate-amine ligase; Provisional; Region: PRK13517 36809006512 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 36809006513 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 36809006514 LGFP repeat; Region: LGFP; pfam08310 36809006515 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 36809006516 active site 36809006517 substrate-binding site [chemical binding]; other site 36809006518 metal-binding site [ion binding] 36809006519 GTP binding site [chemical binding]; other site 36809006520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809006521 dimerization interface [polypeptide binding]; other site 36809006522 putative DNA binding site [nucleotide binding]; other site 36809006523 putative Zn2+ binding site [ion binding]; other site 36809006524 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 36809006525 active site clefts [active] 36809006526 zinc binding site [ion binding]; other site 36809006527 dimer interface [polypeptide binding]; other site 36809006528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809006529 dimerization interface [polypeptide binding]; other site 36809006530 putative DNA binding site [nucleotide binding]; other site 36809006531 putative Zn2+ binding site [ion binding]; other site 36809006532 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 36809006533 putative metal binding site [ion binding]; other site 36809006534 arsenical-resistance protein; Region: acr3; TIGR00832 36809006535 Low molecular weight phosphatase family; Region: LMWPc; cd00115 36809006536 active site 36809006537 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 36809006538 MMPL family; Region: MMPL; cl14618 36809006539 MMPL family; Region: MMPL; pfam03176 36809006540 MMPL family; Region: MMPL; cl14618 36809006541 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809006542 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 36809006543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006544 AMP-binding domain protein; Validated; Region: PRK07529 36809006545 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809006546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809006547 AMP binding site [chemical binding]; other site 36809006548 active site 36809006549 acyl-activating enzyme (AAE) consensus motif; other site 36809006550 acyl-activating enzyme (AAE) consensus motif; other site 36809006551 CoA binding site [chemical binding]; other site 36809006552 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 36809006553 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 36809006554 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 36809006555 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 36809006556 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 36809006557 active site 36809006558 metal binding site [ion binding]; metal-binding site 36809006559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006561 YaeQ protein; Region: YaeQ; pfam07152 36809006562 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 36809006563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809006564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809006565 active site 36809006566 phosphorylation site [posttranslational modification] 36809006567 intermolecular recognition site; other site 36809006568 dimerization interface [polypeptide binding]; other site 36809006569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809006570 DNA binding site [nucleotide binding] 36809006571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809006572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809006573 dimerization interface [polypeptide binding]; other site 36809006574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809006575 dimer interface [polypeptide binding]; other site 36809006576 phosphorylation site [posttranslational modification] 36809006577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809006578 ATP binding site [chemical binding]; other site 36809006579 Mg2+ binding site [ion binding]; other site 36809006580 G-X-G motif; other site 36809006581 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 36809006582 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 36809006583 conserved cys residue [active] 36809006584 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809006585 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809006586 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 36809006587 PAS fold; Region: PAS_3; pfam08447 36809006588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 36809006589 putative active site [active] 36809006590 heme pocket [chemical binding]; other site 36809006591 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 36809006592 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 36809006593 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 36809006594 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 36809006595 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 36809006596 NodB motif; other site 36809006597 active site 36809006598 catalytic site [active] 36809006599 metal binding site [ion binding]; metal-binding site 36809006600 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 36809006601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006603 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 36809006604 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809006605 hypothetical protein; Provisional; Region: PRK02237 36809006606 amino acid transporter; Region: 2A0306; TIGR00909 36809006607 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809006608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809006609 dimerization interface [polypeptide binding]; other site 36809006610 putative DNA binding site [nucleotide binding]; other site 36809006611 putative Zn2+ binding site [ion binding]; other site 36809006612 Cation efflux family; Region: Cation_efflux; cl00316 36809006613 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809006614 putative DNA binding site [nucleotide binding]; other site 36809006615 dimerization interface [polypeptide binding]; other site 36809006616 putative Zn2+ binding site [ion binding]; other site 36809006617 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 36809006618 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 36809006619 active site 36809006620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006622 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 36809006623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006624 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809006625 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809006626 acyl-CoA synthetase; Provisional; Region: PRK13388 36809006627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809006628 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809006629 acyl-activating enzyme (AAE) consensus motif; other site 36809006630 AMP binding site [chemical binding]; other site 36809006631 active site 36809006632 acyl-activating enzyme (AAE) consensus motif; other site 36809006633 CoA binding site [chemical binding]; other site 36809006634 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 36809006635 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 36809006636 inhibitor-cofactor binding pocket; inhibition site 36809006637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809006638 catalytic residue [active] 36809006639 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 36809006640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809006641 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 36809006642 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 36809006643 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 36809006644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809006645 putative substrate translocation pore; other site 36809006646 hypothetical protein; Provisional; Region: PRK06185 36809006647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006648 DNA polymerase I; Provisional; Region: PRK05755 36809006649 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 36809006650 active site 36809006651 metal binding site 1 [ion binding]; metal-binding site 36809006652 putative 5' ssDNA interaction site; other site 36809006653 metal binding site 3; metal-binding site 36809006654 metal binding site 2 [ion binding]; metal-binding site 36809006655 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 36809006656 putative DNA binding site [nucleotide binding]; other site 36809006657 putative metal binding site [ion binding]; other site 36809006658 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 36809006659 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 36809006660 active site 36809006661 DNA binding site [nucleotide binding] 36809006662 catalytic site [active] 36809006663 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 36809006664 active site 36809006665 metal binding site [ion binding]; metal-binding site 36809006666 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 36809006667 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 36809006668 D-pathway; other site 36809006669 Putative ubiquinol binding site [chemical binding]; other site 36809006670 Low-spin heme (heme b) binding site [chemical binding]; other site 36809006671 Putative water exit pathway; other site 36809006672 Binuclear center (heme o3/CuB) [ion binding]; other site 36809006673 K-pathway; other site 36809006674 Putative proton exit pathway; other site 36809006675 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 36809006676 DUF35 OB-fold domain; Region: DUF35; pfam01796 36809006677 lipid-transfer protein; Provisional; Region: PRK06059 36809006678 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809006679 active site 36809006680 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 36809006681 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 36809006682 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 36809006683 Walker A/P-loop; other site 36809006684 ATP binding site [chemical binding]; other site 36809006685 Q-loop/lid; other site 36809006686 ABC transporter signature motif; other site 36809006687 Walker B; other site 36809006688 D-loop; other site 36809006689 H-loop/switch region; other site 36809006690 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 36809006691 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 36809006692 Walker A/P-loop; other site 36809006693 ATP binding site [chemical binding]; other site 36809006694 Q-loop/lid; other site 36809006695 ABC transporter signature motif; other site 36809006696 Walker B; other site 36809006697 D-loop; other site 36809006698 H-loop/switch region; other site 36809006699 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 36809006700 TM-ABC transporter signature motif; other site 36809006701 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 36809006702 TM-ABC transporter signature motif; other site 36809006703 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 36809006704 dimerization interface [polypeptide binding]; other site 36809006705 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 36809006706 ligand binding site [chemical binding]; other site 36809006707 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 36809006708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809006709 active site 36809006710 phosphorylation site [posttranslational modification] 36809006711 intermolecular recognition site; other site 36809006712 dimerization interface [polypeptide binding]; other site 36809006713 ANTAR domain; Region: ANTAR; pfam03861 36809006714 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 36809006715 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 36809006716 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 36809006717 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 36809006718 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 36809006719 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 36809006720 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 36809006721 Walker A/P-loop; other site 36809006722 ATP binding site [chemical binding]; other site 36809006723 Q-loop/lid; other site 36809006724 ABC transporter signature motif; other site 36809006725 Walker B; other site 36809006726 D-loop; other site 36809006727 H-loop/switch region; other site 36809006728 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 36809006729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809006730 Walker A/P-loop; other site 36809006731 ATP binding site [chemical binding]; other site 36809006732 Q-loop/lid; other site 36809006733 ABC transporter signature motif; other site 36809006734 Walker B; other site 36809006735 D-loop; other site 36809006736 H-loop/switch region; other site 36809006737 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 36809006738 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 36809006739 Na binding site [ion binding]; other site 36809006740 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 36809006741 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 36809006742 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 36809006743 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 36809006744 active site 36809006745 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 36809006746 catalytic triad [active] 36809006747 dimer interface [polypeptide binding]; other site 36809006748 pyruvate kinase; Provisional; Region: PRK06247 36809006749 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 36809006750 domain interfaces; other site 36809006751 active site 36809006752 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 36809006753 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 36809006754 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 36809006755 substrate binding site [chemical binding]; other site 36809006756 active site 36809006757 catalytic residues [active] 36809006758 heterodimer interface [polypeptide binding]; other site 36809006759 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 36809006760 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 36809006761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809006762 catalytic residue [active] 36809006763 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 36809006764 active site 36809006765 ribulose/triose binding site [chemical binding]; other site 36809006766 phosphate binding site [ion binding]; other site 36809006767 substrate (anthranilate) binding pocket [chemical binding]; other site 36809006768 product (indole) binding pocket [chemical binding]; other site 36809006769 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 36809006770 anthranilate synthase component I; Provisional; Region: PRK13571 36809006771 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 36809006772 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 36809006773 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809006774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 36809006775 putative DNA binding site [nucleotide binding]; other site 36809006776 putative Zn2+ binding site [ion binding]; other site 36809006777 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809006778 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 36809006779 MMPL family; Region: MMPL; pfam03176 36809006780 MMPL family; Region: MMPL; pfam03176 36809006781 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 36809006782 FAD dependent oxidoreductase; Region: DAO; pfam01266 36809006783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809006784 active site 36809006785 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809006786 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809006787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006788 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809006789 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809006790 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 36809006791 active site clefts [active] 36809006792 zinc binding site [ion binding]; other site 36809006793 dimer interface [polypeptide binding]; other site 36809006794 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 36809006795 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809006796 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 36809006797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809006798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006799 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 36809006800 HIT family signature motif; other site 36809006801 catalytic residue [active] 36809006802 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 36809006803 FMN binding site [chemical binding]; other site 36809006804 dimer interface [polypeptide binding]; other site 36809006805 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 36809006806 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 36809006807 catalytic triad [active] 36809006808 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 36809006809 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 36809006810 substrate binding site [chemical binding]; other site 36809006811 glutamase interaction surface [polypeptide binding]; other site 36809006812 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 36809006813 active site 36809006814 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 36809006815 catalytic residues [active] 36809006816 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 36809006817 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 36809006818 putative active site [active] 36809006819 oxyanion strand; other site 36809006820 catalytic triad [active] 36809006821 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 36809006822 putative active site pocket [active] 36809006823 4-fold oligomerization interface [polypeptide binding]; other site 36809006824 metal binding residues [ion binding]; metal-binding site 36809006825 3-fold/trimer interface [polypeptide binding]; other site 36809006826 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 36809006827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809006828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809006829 homodimer interface [polypeptide binding]; other site 36809006830 catalytic residue [active] 36809006831 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 36809006832 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 36809006833 NAD binding site [chemical binding]; other site 36809006834 dimerization interface [polypeptide binding]; other site 36809006835 product binding site; other site 36809006836 substrate binding site [chemical binding]; other site 36809006837 zinc binding site [ion binding]; other site 36809006838 catalytic residues [active] 36809006839 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809006840 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 36809006841 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 36809006842 dimerization interface [polypeptide binding]; other site 36809006843 active site 36809006844 L-aspartate oxidase; Provisional; Region: PRK07804 36809006845 L-aspartate oxidase; Provisional; Region: PRK06175 36809006846 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 36809006847 quinolinate synthetase; Provisional; Region: PRK09375 36809006848 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 36809006849 nudix motif; other site 36809006850 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 36809006851 Secretory lipase; Region: LIP; pfam03583 36809006852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809006853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809006855 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 36809006856 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 36809006857 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 36809006858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809006859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809006860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 36809006861 dimerization interface [polypeptide binding]; other site 36809006862 malate:quinone oxidoreductase; Validated; Region: PRK05257 36809006863 Predicted dehydrogenase [General function prediction only]; Region: COG0579 36809006864 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 36809006865 biotin synthase; Validated; Region: PRK06256 36809006866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809006867 FeS/SAM binding site; other site 36809006868 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 36809006869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809006870 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 36809006871 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 36809006872 AAA domain; Region: AAA_26; pfam13500 36809006873 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 36809006874 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 36809006875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809006876 catalytic residue [active] 36809006877 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809006878 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809006879 inhibitor-cofactor binding pocket; inhibition site 36809006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809006881 catalytic residue [active] 36809006882 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809006883 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 36809006884 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 36809006885 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 36809006886 active site 36809006887 catalytic site [active] 36809006888 threonine dehydratase; Validated; Region: PRK08639 36809006889 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 36809006890 tetramer interface [polypeptide binding]; other site 36809006891 catalytic residue [active] 36809006892 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 36809006893 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809006894 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 36809006895 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 36809006896 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 36809006897 active site 36809006898 PHP Thumb interface [polypeptide binding]; other site 36809006899 metal binding site [ion binding]; metal-binding site 36809006900 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 36809006901 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 36809006902 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 36809006903 generic binding surface II; other site 36809006904 generic binding surface I; other site 36809006905 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 36809006906 Predicted permeases [General function prediction only]; Region: RarD; COG2962 36809006907 EamA-like transporter family; Region: EamA; cl17759 36809006908 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 36809006909 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 36809006910 active site 36809006911 lipoprotein signal peptidase; Provisional; Region: PRK14764 36809006912 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 36809006913 active site 36809006914 homotetramer interface [polypeptide binding]; other site 36809006915 homodimer interface [polypeptide binding]; other site 36809006916 DNA polymerase IV; Provisional; Region: PRK03348 36809006917 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 36809006918 active site 36809006919 DNA binding site [nucleotide binding] 36809006920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809006921 S-adenosylmethionine binding site [chemical binding]; other site 36809006922 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 36809006923 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 36809006924 HIGH motif; other site 36809006925 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 36809006926 active site 36809006927 KMSKS motif; other site 36809006928 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 36809006929 tRNA binding surface [nucleotide binding]; other site 36809006930 anticodon binding site; other site 36809006931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809006932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809006933 putative substrate translocation pore; other site 36809006934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809006935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809006936 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 36809006937 putative dimerization interface [polypeptide binding]; other site 36809006938 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 36809006939 metal binding triad [ion binding]; metal-binding site 36809006940 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 36809006941 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 36809006942 active site 36809006943 catalytic site [active] 36809006944 substrate binding site [chemical binding]; other site 36809006945 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 36809006946 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 36809006947 Walker A; other site 36809006948 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 36809006949 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 36809006950 active site 36809006951 substrate binding site [chemical binding]; other site 36809006952 coenzyme B12 binding site [chemical binding]; other site 36809006953 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 36809006954 B12 binding site [chemical binding]; other site 36809006955 cobalt ligand [ion binding]; other site 36809006956 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 36809006957 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 36809006958 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 36809006959 Uncharacterized conserved protein [Function unknown]; Region: COG0398 36809006960 DoxX-like family; Region: DoxX_2; pfam13564 36809006961 DoxX-like family; Region: DoxX_2; pfam13564 36809006962 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 36809006963 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 36809006964 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 36809006965 MgtE intracellular N domain; Region: MgtE_N; smart00924 36809006966 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 36809006967 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 36809006968 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 36809006969 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 36809006970 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 36809006971 ferrochelatase; Reviewed; Region: hemH; PRK00035 36809006972 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 36809006973 C-terminal domain interface [polypeptide binding]; other site 36809006974 active site 36809006975 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 36809006976 active site 36809006977 N-terminal domain interface [polypeptide binding]; other site 36809006978 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 36809006979 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 36809006980 NAD binding site [chemical binding]; other site 36809006981 homotetramer interface [polypeptide binding]; other site 36809006982 homodimer interface [polypeptide binding]; other site 36809006983 substrate binding site [chemical binding]; other site 36809006984 active site 36809006985 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 36809006986 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 36809006987 NAD(P) binding site [chemical binding]; other site 36809006988 homotetramer interface [polypeptide binding]; other site 36809006989 homodimer interface [polypeptide binding]; other site 36809006990 active site 36809006991 hypothetical protein; Provisional; Region: PRK13685 36809006992 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 36809006993 metal ion-dependent adhesion site (MIDAS); other site 36809006994 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 36809006995 Protein of unknown function DUF58; Region: DUF58; pfam01882 36809006996 MoxR-like ATPases [General function prediction only]; Region: COG0714 36809006997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809006998 Walker A motif; other site 36809006999 ATP binding site [chemical binding]; other site 36809007000 Walker B motif; other site 36809007001 arginine finger; other site 36809007002 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 36809007003 NlpC/P60 family; Region: NLPC_P60; pfam00877 36809007004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 36809007005 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 36809007006 NlpC/P60 family; Region: NLPC_P60; pfam00877 36809007007 aconitate hydratase; Validated; Region: PRK09277 36809007008 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 36809007009 substrate binding site [chemical binding]; other site 36809007010 ligand binding site [chemical binding]; other site 36809007011 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 36809007012 substrate binding site [chemical binding]; other site 36809007013 TetR family transcriptional regulator; Provisional; Region: PRK14996 36809007014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007015 DinB superfamily; Region: DinB_2; pfam12867 36809007016 AMIN domain; Region: AMIN; pfam11741 36809007017 Helix-turn-helix domain; Region: HTH_38; pfam13936 36809007018 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 36809007019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809007020 ABC transporter; Region: ABC_tran_2; pfam12848 36809007021 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809007022 enoyl-CoA hydratase; Provisional; Region: PRK05864 36809007023 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809007024 substrate binding site [chemical binding]; other site 36809007025 oxyanion hole (OAH) forming residues; other site 36809007026 trimer interface [polypeptide binding]; other site 36809007027 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 36809007028 catalytic residues [active] 36809007029 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 36809007030 putative active site [active] 36809007031 putative FMN binding site [chemical binding]; other site 36809007032 putative substrate binding site [chemical binding]; other site 36809007033 putative catalytic residue [active] 36809007034 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 36809007035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809007036 Coenzyme A binding pocket [chemical binding]; other site 36809007037 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 36809007038 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 36809007039 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 36809007040 trimerization site [polypeptide binding]; other site 36809007041 active site 36809007042 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 36809007043 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809007044 catalytic residue [active] 36809007045 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 36809007046 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 36809007047 Walker A/P-loop; other site 36809007048 ATP binding site [chemical binding]; other site 36809007049 Q-loop/lid; other site 36809007050 ABC transporter signature motif; other site 36809007051 Walker B; other site 36809007052 D-loop; other site 36809007053 H-loop/switch region; other site 36809007054 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 36809007055 FeS assembly protein SufD; Region: sufD; TIGR01981 36809007056 FeS assembly protein SufB; Region: sufB; TIGR01980 36809007057 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 36809007058 Predicted transcriptional regulator [Transcription]; Region: COG2345 36809007059 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809007060 putative DNA binding site [nucleotide binding]; other site 36809007061 putative Zn2+ binding site [ion binding]; other site 36809007062 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 36809007063 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 36809007064 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 36809007065 Walker A/P-loop; other site 36809007066 ATP binding site [chemical binding]; other site 36809007067 Q-loop/lid; other site 36809007068 ABC transporter signature motif; other site 36809007069 Walker B; other site 36809007070 D-loop; other site 36809007071 H-loop/switch region; other site 36809007072 ABC-2 type transporter; Region: ABC2_membrane; cl17235 36809007073 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 36809007074 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 36809007075 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809007076 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809007077 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 36809007078 NADP binding site [chemical binding]; other site 36809007079 dimer interface [polypeptide binding]; other site 36809007080 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 36809007081 putative active site [active] 36809007082 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 36809007083 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 36809007084 TPP-binding site [chemical binding]; other site 36809007085 dimer interface [polypeptide binding]; other site 36809007086 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 36809007087 PYR/PP interface [polypeptide binding]; other site 36809007088 dimer interface [polypeptide binding]; other site 36809007089 TPP binding site [chemical binding]; other site 36809007090 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 36809007091 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 36809007092 putative active site [active] 36809007093 catalytic residue [active] 36809007094 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 36809007095 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 36809007096 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 36809007097 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 36809007098 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 36809007099 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 36809007100 putative active site [active] 36809007101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809007102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809007103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 36809007104 dimerization interface [polypeptide binding]; other site 36809007105 CoA-transferase family III; Region: CoA_transf_3; cl19215 36809007106 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 36809007107 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 36809007108 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 36809007109 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 36809007110 Subunit I/III interface [polypeptide binding]; other site 36809007111 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 36809007112 Outer membrane protein family (DUF1597); Region: DUF1597; cl19301 36809007113 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 36809007114 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 36809007115 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 36809007116 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 36809007117 substrate binding site [chemical binding]; other site 36809007118 dimer interface [polypeptide binding]; other site 36809007119 catalytic triad [active] 36809007120 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 36809007121 substrate binding site [chemical binding]; other site 36809007122 hinge regions; other site 36809007123 ADP binding site [chemical binding]; other site 36809007124 catalytic site [active] 36809007125 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 36809007126 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 36809007127 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 36809007128 H+ Antiporter protein; Region: 2A0121; TIGR00900 36809007129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809007130 putative substrate translocation pore; other site 36809007131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 36809007132 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 36809007133 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 36809007134 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 36809007135 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 36809007136 phosphate binding site [ion binding]; other site 36809007137 putative substrate binding pocket [chemical binding]; other site 36809007138 dimer interface [polypeptide binding]; other site 36809007139 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 36809007140 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 36809007141 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 36809007142 GIY-YIG motif/motif A; other site 36809007143 active site 36809007144 catalytic site [active] 36809007145 putative DNA binding site [nucleotide binding]; other site 36809007146 metal binding site [ion binding]; metal-binding site 36809007147 UvrB/uvrC motif; Region: UVR; pfam02151 36809007148 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 36809007149 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 36809007150 Cupredoxin superfamily; Region: Cupredoxin; cl19115 36809007151 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 36809007152 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 36809007153 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 36809007154 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 36809007155 ethanolamine permease; Region: 2A0305; TIGR00908 36809007156 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809007157 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 36809007158 NAD(P) binding site [chemical binding]; other site 36809007159 catalytic residues [active] 36809007160 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 36809007161 Bacterial PH domain; Region: bPH_6; pfam10756 36809007162 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 36809007163 homopentamer interface [polypeptide binding]; other site 36809007164 active site 36809007165 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 36809007166 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 36809007167 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 36809007168 dimerization interface [polypeptide binding]; other site 36809007169 active site 36809007170 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 36809007171 Lumazine binding domain; Region: Lum_binding; pfam00677 36809007172 Lumazine binding domain; Region: Lum_binding; pfam00677 36809007173 MspA; Region: MspA; pfam09203 36809007174 MspA; Region: MspA; pfam09203 36809007175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809007176 dimer interface [polypeptide binding]; other site 36809007177 conserved gate region; other site 36809007178 putative PBP binding loops; other site 36809007179 ABC-ATPase subunit interface; other site 36809007180 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 36809007181 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 36809007182 Walker A/P-loop; other site 36809007183 ATP binding site [chemical binding]; other site 36809007184 Q-loop/lid; other site 36809007185 ABC transporter signature motif; other site 36809007186 Walker B; other site 36809007187 D-loop; other site 36809007188 H-loop/switch region; other site 36809007189 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 36809007190 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 36809007191 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 36809007192 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 36809007193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809007194 putative substrate translocation pore; other site 36809007195 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 36809007196 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 36809007197 catalytic motif [active] 36809007198 Zn binding site [ion binding]; other site 36809007199 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 36809007200 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 36809007201 substrate binding site [chemical binding]; other site 36809007202 hexamer interface [polypeptide binding]; other site 36809007203 metal binding site [ion binding]; metal-binding site 36809007204 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 36809007205 putative RNA binding site [nucleotide binding]; other site 36809007206 16S rRNA methyltransferase B; Provisional; Region: PRK14902 36809007207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809007208 S-adenosylmethionine binding site [chemical binding]; other site 36809007209 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 36809007210 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 36809007211 putative active site [active] 36809007212 substrate binding site [chemical binding]; other site 36809007213 putative cosubstrate binding site; other site 36809007214 catalytic site [active] 36809007215 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 36809007216 substrate binding site [chemical binding]; other site 36809007217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007219 primosome assembly protein PriA; Provisional; Region: PRK14873 36809007220 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809007221 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809007222 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 36809007223 Na binding site [ion binding]; other site 36809007224 putative substrate binding site [chemical binding]; other site 36809007225 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809007226 phenylhydantoinase; Validated; Region: PRK08323 36809007227 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 36809007228 tetramer interface [polypeptide binding]; other site 36809007229 active site 36809007230 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 36809007231 active site 36809007232 catalytic triad [active] 36809007233 dimer interface [polypeptide binding]; other site 36809007234 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 36809007235 S-adenosylmethionine synthetase; Validated; Region: PRK05250 36809007236 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 36809007237 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 36809007238 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 36809007239 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 36809007240 Flavoprotein; Region: Flavoprotein; cl19190 36809007241 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 36809007242 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 36809007243 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 36809007244 catalytic site [active] 36809007245 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 36809007246 Acyltransferase family; Region: Acyl_transf_3; pfam01757 36809007247 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 36809007248 active site 36809007249 dimer interface [polypeptide binding]; other site 36809007250 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 36809007251 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 36809007252 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809007253 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 36809007254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 36809007255 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809007256 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 36809007257 IMP binding site; other site 36809007258 dimer interface [polypeptide binding]; other site 36809007259 interdomain contacts; other site 36809007260 partial ornithine binding site; other site 36809007261 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 36809007262 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 36809007263 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 36809007264 catalytic site [active] 36809007265 subunit interface [polypeptide binding]; other site 36809007266 dihydroorotase; Validated; Region: pyrC; PRK09357 36809007267 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 36809007268 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 36809007269 active site 36809007270 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 36809007271 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 36809007272 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 36809007273 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809007274 active site 36809007275 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809007276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809007277 S-adenosylmethionine binding site [chemical binding]; other site 36809007278 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809007279 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 36809007280 putative RNA binding site [nucleotide binding]; other site 36809007281 elongation factor P; Validated; Region: PRK00529 36809007282 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 36809007283 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 36809007284 RNA binding site [nucleotide binding]; other site 36809007285 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 36809007286 RNA binding site [nucleotide binding]; other site 36809007287 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 36809007288 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 36809007289 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 36809007290 active site 36809007291 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 36809007292 trimer interface [polypeptide binding]; other site 36809007293 active site 36809007294 dimer interface [polypeptide binding]; other site 36809007295 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 36809007296 active site 36809007297 dimer interface [polypeptide binding]; other site 36809007298 metal binding site [ion binding]; metal-binding site 36809007299 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 36809007300 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 36809007301 ADP binding site [chemical binding]; other site 36809007302 magnesium binding site [ion binding]; other site 36809007303 putative shikimate binding site; other site 36809007304 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 36809007305 Tetramer interface [polypeptide binding]; other site 36809007306 active site 36809007307 FMN-binding site [chemical binding]; other site 36809007308 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 36809007309 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 36809007310 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 36809007311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809007312 S-adenosylmethionine binding site [chemical binding]; other site 36809007313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007314 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809007315 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 36809007316 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 36809007317 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 36809007318 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 36809007319 shikimate binding site; other site 36809007320 NAD(P) binding site [chemical binding]; other site 36809007321 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 36809007322 dimerization interface [polypeptide binding]; other site 36809007323 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 36809007324 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 36809007325 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 36809007326 motif 1; other site 36809007327 active site 36809007328 motif 2; other site 36809007329 motif 3; other site 36809007330 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 36809007331 DHHA1 domain; Region: DHHA1; pfam02272 36809007332 recombination factor protein RarA; Reviewed; Region: PRK13342 36809007333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809007334 Walker A motif; other site 36809007335 ATP binding site [chemical binding]; other site 36809007336 Walker B motif; other site 36809007337 arginine finger; other site 36809007338 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 36809007339 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 36809007340 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 36809007341 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 36809007342 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 36809007343 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 36809007344 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 36809007345 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 36809007346 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl19824 36809007347 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 36809007348 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 36809007349 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 36809007350 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 36809007351 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809007352 Predicted permease; Region: DUF318; cl17795 36809007353 TIGR03943 family protein; Region: TIGR03943 36809007354 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 36809007355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809007356 motif II; other site 36809007357 Domain of unknown function (DUF389); Region: DUF389; pfam04087 36809007358 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 36809007359 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 36809007360 dimer interface [polypeptide binding]; other site 36809007361 anticodon binding site; other site 36809007362 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 36809007363 homodimer interface [polypeptide binding]; other site 36809007364 motif 1; other site 36809007365 active site 36809007366 motif 2; other site 36809007367 GAD domain; Region: GAD; pfam02938 36809007368 motif 3; other site 36809007369 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 36809007370 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809007371 substrate binding pocket [chemical binding]; other site 36809007372 catalytic triad [active] 36809007373 Predicted metalloprotease [General function prediction only]; Region: COG2321 36809007374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809007375 Radical SAM superfamily; Region: Radical_SAM; pfam04055 36809007376 FeS/SAM binding site; other site 36809007377 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 36809007378 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 36809007379 putative active site pocket [active] 36809007380 dimerization interface [polypeptide binding]; other site 36809007381 putative catalytic residue [active] 36809007382 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 36809007383 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 36809007384 dimer interface [polypeptide binding]; other site 36809007385 motif 1; other site 36809007386 active site 36809007387 motif 2; other site 36809007388 motif 3; other site 36809007389 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 36809007390 anticodon binding site; other site 36809007391 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 36809007392 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 36809007393 active site 36809007394 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 36809007395 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 36809007396 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 36809007397 Zn2+ binding site [ion binding]; other site 36809007398 Mg2+ binding site [ion binding]; other site 36809007399 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 36809007400 synthetase active site [active] 36809007401 NTP binding site [chemical binding]; other site 36809007402 metal binding site [ion binding]; metal-binding site 36809007403 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 36809007404 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 36809007405 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809007406 active site 36809007407 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 36809007408 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 36809007409 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 36809007410 Protein export membrane protein; Region: SecD_SecF; pfam02355 36809007411 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 36809007412 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 36809007413 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 36809007414 Proline-rich; Region: Pro-rich; pfam15240 36809007415 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 36809007416 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 36809007417 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 36809007418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809007419 Walker A motif; other site 36809007420 ATP binding site [chemical binding]; other site 36809007421 Walker B motif; other site 36809007422 arginine finger; other site 36809007423 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 36809007424 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 36809007425 RuvA N terminal domain; Region: RuvA_N; pfam01330 36809007426 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 36809007427 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 36809007428 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 36809007429 putative DNA-binding cleft [nucleotide binding]; other site 36809007430 dimer interface [polypeptide binding]; other site 36809007431 active site 36809007432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007434 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 36809007435 active site 36809007436 hypothetical protein; Validated; Region: PRK00110 36809007437 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 36809007438 predicted active site [active] 36809007439 catalytic triad [active] 36809007440 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 36809007441 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 36809007442 active site 36809007443 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 36809007444 catalytic triad [active] 36809007445 dimer interface [polypeptide binding]; other site 36809007446 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 36809007447 active site 36809007448 multimer interface [polypeptide binding]; other site 36809007449 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 36809007450 nudix motif; other site 36809007451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809007452 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 36809007453 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 36809007454 putative acyl-acceptor binding pocket; other site 36809007455 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 36809007456 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 36809007457 nucleotide binding site/active site [active] 36809007458 HIT family signature motif; other site 36809007459 catalytic residue [active] 36809007460 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 36809007461 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 36809007462 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 36809007463 active site 36809007464 dimer interface [polypeptide binding]; other site 36809007465 motif 1; other site 36809007466 motif 2; other site 36809007467 motif 3; other site 36809007468 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 36809007469 anticodon binding site; other site 36809007470 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 36809007471 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 36809007472 conserved cys residue [active] 36809007473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809007474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809007475 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 36809007476 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 36809007477 conserved cys residue [active] 36809007478 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809007479 CoenzymeA binding site [chemical binding]; other site 36809007480 subunit interaction site [polypeptide binding]; other site 36809007481 PHB binding site; other site 36809007482 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 36809007483 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 36809007484 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 36809007485 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 36809007486 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809007487 active site 36809007488 AMP binding site [chemical binding]; other site 36809007489 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 36809007490 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 36809007491 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 36809007492 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 36809007493 homotrimer interaction site [polypeptide binding]; other site 36809007494 putative active site [active] 36809007495 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 36809007496 active site 36809007497 hypothetical protein; Provisional; Region: PRK06208 36809007498 intersubunit interface [polypeptide binding]; other site 36809007499 active site 36809007500 Zn2+ binding site [ion binding]; other site 36809007501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007503 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 36809007504 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 36809007505 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 36809007506 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809007507 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 36809007508 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 36809007509 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 36809007510 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 36809007511 CAAX protease self-immunity; Region: Abi; pfam02517 36809007512 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 36809007513 putative active site [active] 36809007514 catalytic triad [active] 36809007515 putative dimer interface [polypeptide binding]; other site 36809007516 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 36809007517 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 36809007518 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 36809007519 XdhC Rossmann domain; Region: XdhC_C; pfam13478 36809007520 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 36809007521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809007522 catalytic loop [active] 36809007523 iron binding site [ion binding]; other site 36809007524 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 36809007525 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 36809007526 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 36809007527 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 36809007528 FAD binding domain; Region: FAD_binding_4; cl19922 36809007529 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 36809007530 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 36809007531 active site 36809007532 putative substrate binding pocket [chemical binding]; other site 36809007533 guanine deaminase; Provisional; Region: PRK09228 36809007534 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 36809007535 active site 36809007536 urate oxidase; Region: urate_oxi; TIGR03383 36809007537 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 36809007538 active site 36809007539 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 36809007540 active site 36809007541 homotetramer interface [polypeptide binding]; other site 36809007542 putative OHCU decarboxylase; Provisional; Region: PRK13798 36809007543 Sulfate transporter family; Region: Sulfate_transp; cl19250 36809007544 xanthine permease; Region: pbuX; TIGR03173 36809007545 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 36809007546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809007547 Transcriptional regulators [Transcription]; Region: GntR; COG1802 36809007548 DNA-binding site [nucleotide binding]; DNA binding site 36809007549 FCD domain; Region: FCD; pfam07729 36809007550 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 36809007551 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 36809007552 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 36809007553 active site 36809007554 catalytic site [active] 36809007555 tetramer interface [polypeptide binding]; other site 36809007556 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 36809007557 Na binding site [ion binding]; other site 36809007558 putative substrate binding site [chemical binding]; other site 36809007559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 36809007560 active site 36809007561 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 36809007562 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 36809007563 allantoicase; Provisional; Region: PRK13257 36809007564 Allantoicase repeat; Region: Allantoicase; pfam03561 36809007565 Allantoicase repeat; Region: Allantoicase; pfam03561 36809007566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 36809007567 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 36809007568 active site 36809007569 catalytic tetrad [active] 36809007570 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 36809007571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809007572 nucleophilic elbow; other site 36809007573 catalytic triad; other site 36809007574 short chain dehydrogenase; Provisional; Region: PRK06181 36809007575 classical (c) SDRs; Region: SDR_c; cd05233 36809007576 NAD(P) binding site [chemical binding]; other site 36809007577 active site 36809007578 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 36809007579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809007580 mce related protein; Region: MCE; pfam02470 36809007581 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809007582 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809007583 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809007584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809007585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809007586 active site 36809007587 short chain dehydrogenase; Provisional; Region: PRK07791 36809007588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809007589 NAD(P) binding site [chemical binding]; other site 36809007590 active site 36809007591 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809007592 active site 36809007593 catalytic site [active] 36809007594 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809007595 active site 2 [active] 36809007596 active site 1 [active] 36809007597 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 36809007598 hydrophobic ligand binding site; other site 36809007599 lipid-transfer protein; Provisional; Region: PRK08256 36809007600 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809007601 active site 36809007602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007604 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 36809007605 Peptidase family M48; Region: Peptidase_M48; pfam01435 36809007606 Yqey-like protein; Region: YqeY; cl17540 36809007607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809007610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809007611 putative substrate translocation pore; other site 36809007612 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 36809007613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809007614 Mucin-like glycoprotein; Region: Mucin; pfam01456 36809007615 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809007616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809007617 S-adenosylmethionine binding site [chemical binding]; other site 36809007618 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 36809007619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809007620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809007621 acyl-activating enzyme (AAE) consensus motif; other site 36809007622 acyl-activating enzyme (AAE) consensus motif; other site 36809007623 AMP binding site [chemical binding]; other site 36809007624 active site 36809007625 CoA binding site [chemical binding]; other site 36809007626 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809007627 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 36809007628 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 36809007629 putative NAD(P) binding site [chemical binding]; other site 36809007630 active site 36809007631 putative substrate binding site [chemical binding]; other site 36809007632 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 36809007633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809007634 acyl-activating enzyme (AAE) consensus motif; other site 36809007635 AMP binding site [chemical binding]; other site 36809007636 active site 36809007637 CoA binding site [chemical binding]; other site 36809007638 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809007639 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 36809007640 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 36809007641 putative NAD(P) binding site [chemical binding]; other site 36809007642 active site 36809007643 putative substrate binding site [chemical binding]; other site 36809007644 SnoaL-like domain; Region: SnoaL_4; pfam13577 36809007645 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 36809007646 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 36809007647 active site 36809007648 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809007649 catalytic loop [active] 36809007650 iron binding site [ion binding]; other site 36809007651 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 36809007652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007654 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809007655 active site 36809007656 ATP binding site [chemical binding]; other site 36809007657 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 36809007658 hydrophobic ligand binding site; other site 36809007659 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 36809007660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809007661 NAD(P) binding site [chemical binding]; other site 36809007662 active site 36809007663 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 36809007664 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 36809007665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809007666 Walker A motif; other site 36809007667 ATP binding site [chemical binding]; other site 36809007668 Walker B motif; other site 36809007669 hypothetical protein; Provisional; Region: PRK14059 36809007670 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809007671 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809007672 TAP-like protein; Region: Abhydrolase_4; pfam08386 36809007673 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 36809007674 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 36809007675 Flagellar L-ring protein; Region: FlgH; cl19182 36809007676 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 36809007677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809007678 putative substrate translocation pore; other site 36809007679 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 36809007680 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 36809007681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809007682 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 36809007683 substrate binding site [chemical binding]; other site 36809007684 active site 36809007685 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 36809007686 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 36809007687 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 36809007688 catalytic site [active] 36809007689 putative active site [active] 36809007690 putative substrate binding site [chemical binding]; other site 36809007691 HRDC domain; Region: HRDC; cl02578 36809007692 Chloramphenicol acetyltransferase; Region: CAT; cl02008 36809007693 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 36809007694 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 36809007695 TPP-binding site; other site 36809007696 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 36809007697 PYR/PP interface [polypeptide binding]; other site 36809007698 dimer interface [polypeptide binding]; other site 36809007699 TPP binding site [chemical binding]; other site 36809007700 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 36809007701 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 36809007702 TRAM domain; Region: TRAM; pfam01938 36809007703 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 36809007704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 36809007705 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 36809007706 K+ potassium transporter; Region: K_trans; cl15781 36809007707 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 36809007708 TrkA-N domain; Region: TrkA_N; pfam02254 36809007709 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 36809007710 TrkA-N domain; Region: TrkA_N; pfam02254 36809007711 TrkA-C domain; Region: TrkA_C; pfam02080 36809007712 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 36809007713 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 36809007714 generic binding surface II; other site 36809007715 ssDNA binding site; other site 36809007716 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809007717 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 36809007718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809007719 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 36809007720 DNA binding residues [nucleotide binding] 36809007721 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 36809007722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809007723 NAD(P) binding site [chemical binding]; other site 36809007724 active site 36809007725 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809007726 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 36809007727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 36809007728 trimer interface [polypeptide binding]; other site 36809007729 active site 36809007730 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 36809007731 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 36809007732 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 36809007733 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 36809007734 active site 36809007735 dimerization interface [polypeptide binding]; other site 36809007736 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 36809007737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 36809007738 nucleotide binding site [chemical binding]; other site 36809007739 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 36809007740 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 36809007741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809007742 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 36809007743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809007744 DNA binding residues [nucleotide binding] 36809007745 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 36809007746 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 36809007747 DNA binding site [nucleotide binding] 36809007748 active site 36809007749 Predicted membrane protein [Function unknown]; Region: COG3918 36809007750 mercuric reductase; Validated; Region: PRK06370 36809007751 Squalene epoxidase; Region: SE; cl17314 36809007752 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809007753 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809007754 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 36809007755 active site 36809007756 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809007757 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 36809007758 homotrimer interaction site [polypeptide binding]; other site 36809007759 putative active site [active] 36809007760 Transcriptional regulators [Transcription]; Region: FadR; COG2186 36809007761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809007762 DNA-binding site [nucleotide binding]; DNA binding site 36809007763 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 36809007764 hypothetical protein; Provisional; Region: PRK05409 36809007765 Protein of unknown function (DUF952); Region: DUF952; cl01393 36809007766 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 36809007767 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 36809007768 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 36809007769 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 36809007770 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 36809007771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809007772 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 36809007773 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809007774 DNA binding residues [nucleotide binding] 36809007775 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 36809007776 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 36809007777 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 36809007778 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 36809007779 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 36809007780 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 36809007781 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 36809007782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809007783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809007784 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809007785 PAC2 family; Region: PAC2; pfam09754 36809007786 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809007787 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809007788 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809007789 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 36809007790 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 36809007791 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 36809007792 C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit; Region: Zn-ribbon; cl02609 36809007793 Zn binding site [ion binding]; other site 36809007794 ATP cone domain; Region: ATP-cone; pfam03477 36809007795 LysM domain; Region: LysM; pfam01476 36809007796 LexA repressor; Validated; Region: PRK00215 36809007797 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 36809007798 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 36809007799 Catalytic site [active] 36809007800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809007801 Coenzyme A binding pocket [chemical binding]; other site 36809007802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809007803 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809007804 active site 36809007805 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 36809007806 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 36809007807 molybdopterin cofactor binding site; other site 36809007808 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 36809007809 molybdopterin cofactor binding site; other site 36809007810 GTPases [General function prediction only]; Region: HflX; COG2262 36809007811 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 36809007812 HflX GTPase family; Region: HflX; cd01878 36809007813 G1 box; other site 36809007814 GTP/Mg2+ binding site [chemical binding]; other site 36809007815 Switch I region; other site 36809007816 G2 box; other site 36809007817 G3 box; other site 36809007818 Switch II region; other site 36809007819 G4 box; other site 36809007820 G5 box; other site 36809007821 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 36809007822 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 36809007823 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 36809007824 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 36809007825 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 36809007826 active site 36809007827 metal binding site [ion binding]; metal-binding site 36809007828 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 36809007829 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 36809007830 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 36809007831 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 36809007832 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 36809007833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809007834 FeS/SAM binding site; other site 36809007835 Dehydratase family; Region: ILVD_EDD; cl00340 36809007836 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 36809007837 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 36809007838 Walker A/P-loop; other site 36809007839 ATP binding site [chemical binding]; other site 36809007840 Q-loop/lid; other site 36809007841 ABC transporter signature motif; other site 36809007842 Walker B; other site 36809007843 D-loop; other site 36809007844 H-loop/switch region; other site 36809007845 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 36809007846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 36809007847 substrate binding pocket [chemical binding]; other site 36809007848 membrane-bound complex binding site; other site 36809007849 hinge residues; other site 36809007850 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 36809007851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809007852 dimer interface [polypeptide binding]; other site 36809007853 conserved gate region; other site 36809007854 putative PBP binding loops; other site 36809007855 ABC-ATPase subunit interface; other site 36809007856 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 36809007857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809007858 dimer interface [polypeptide binding]; other site 36809007859 conserved gate region; other site 36809007860 putative PBP binding loops; other site 36809007861 ABC-ATPase subunit interface; other site 36809007862 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 36809007863 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 36809007864 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 36809007865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 36809007866 active site 36809007867 metal binding site [ion binding]; metal-binding site 36809007868 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 36809007869 CGNR zinc finger; Region: zf-CGNR; pfam11706 36809007870 recombination regulator RecX; Reviewed; Region: recX; PRK00117 36809007871 recombinase A; Provisional; Region: recA; PRK09354 36809007872 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 36809007873 hexamer interface [polypeptide binding]; other site 36809007874 Walker A motif; other site 36809007875 ATP binding site [chemical binding]; other site 36809007876 Walker B motif; other site 36809007877 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 36809007878 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 36809007879 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 36809007880 homodimer interface [polypeptide binding]; other site 36809007881 active site 36809007882 TDP-binding site; other site 36809007883 acceptor substrate-binding pocket; other site 36809007884 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 36809007885 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 36809007886 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 36809007887 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 36809007888 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 36809007889 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809007890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809007891 non-specific DNA binding site [nucleotide binding]; other site 36809007892 salt bridge; other site 36809007893 sequence-specific DNA binding site [nucleotide binding]; other site 36809007894 Helix-turn-helix domain; Region: HTH_31; pfam13560 36809007895 short chain dehydrogenase; Provisional; Region: PRK05854 36809007896 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 36809007897 NAD(P) binding site [chemical binding]; other site 36809007898 active site 36809007899 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 36809007900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809007901 Coenzyme A binding pocket [chemical binding]; other site 36809007902 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809007903 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809007904 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 36809007905 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 36809007906 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 36809007907 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 36809007908 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809007909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809007910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809007911 Uncharacterized conserved protein [Function unknown]; Region: COG4278 36809007912 Uncharacterized conserved protein [Function unknown]; Region: COG1359 36809007913 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 36809007914 classical (c) SDRs; Region: SDR_c; cd05233 36809007915 NAD(P) binding site [chemical binding]; other site 36809007916 active site 36809007917 Leucine carboxyl methyltransferase; Region: LCM; cl01306 36809007918 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 36809007919 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809007920 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 36809007921 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 36809007922 dimer interface [polypeptide binding]; other site 36809007923 active site 36809007924 catalytic residue [active] 36809007925 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 36809007926 YceI-like domain; Region: YceI; pfam04264 36809007927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 36809007928 Thioredoxin; Region: Thioredoxin_4; cl17273 36809007929 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 36809007930 catalytic residues [active] 36809007931 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 36809007932 folate binding site [chemical binding]; other site 36809007933 NADP+ binding site [chemical binding]; other site 36809007934 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 36809007935 dimerization interface [polypeptide binding]; other site 36809007936 active site 36809007937 acyltransferase PapA5; Provisional; Region: PRK09294 36809007938 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 36809007939 dihydrodipicolinate reductase; Provisional; Region: PRK00048 36809007940 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 36809007941 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 36809007942 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 36809007943 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 36809007944 Sulfate transporter family; Region: Sulfate_transp; pfam00916 36809007945 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 36809007946 active site clefts [active] 36809007947 zinc binding site [ion binding]; other site 36809007948 dimer interface [polypeptide binding]; other site 36809007949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809007950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809007951 putative DNA binding site [nucleotide binding]; other site 36809007952 putative Zn2+ binding site [ion binding]; other site 36809007953 AsnC family; Region: AsnC_trans_reg; pfam01037 36809007954 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 36809007955 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 36809007956 hexamer interface [polypeptide binding]; other site 36809007957 ligand binding site [chemical binding]; other site 36809007958 putative active site [active] 36809007959 NAD(P) binding site [chemical binding]; other site 36809007960 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809007961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809007962 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 36809007963 classical (c) SDRs; Region: SDR_c; cd05233 36809007964 NAD(P) binding site [chemical binding]; other site 36809007965 active site 36809007966 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 36809007967 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 36809007968 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 36809007969 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 36809007970 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 36809007971 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 36809007972 oligomer interface [polypeptide binding]; other site 36809007973 RNA binding site [nucleotide binding]; other site 36809007974 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 36809007975 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 36809007976 RNase E interface [polypeptide binding]; other site 36809007977 trimer interface [polypeptide binding]; other site 36809007978 active site 36809007979 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 36809007980 putative nucleic acid binding region [nucleotide binding]; other site 36809007981 G-X-X-G motif; other site 36809007982 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 36809007983 RNA binding site [nucleotide binding]; other site 36809007984 domain interface; other site 36809007985 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 36809007986 16S/18S rRNA binding site [nucleotide binding]; other site 36809007987 S13e-L30e interaction site [polypeptide binding]; other site 36809007988 25S rRNA binding site [nucleotide binding]; other site 36809007989 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 36809007990 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 36809007991 active site 36809007992 Riboflavin kinase; Region: Flavokinase; smart00904 36809007993 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 36809007994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809007995 putative DNA binding site [nucleotide binding]; other site 36809007996 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 36809007997 FeoA domain; Region: FeoA; pfam04023 36809007998 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 36809007999 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 36809008000 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 36809008001 Putative toxin 57; Region: Toxin_57; pfam15535 36809008002 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 36809008003 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 36809008004 RNA binding site [nucleotide binding]; other site 36809008005 active site 36809008006 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 36809008007 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 36809008008 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 36809008009 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 36809008010 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 36809008011 active site 36809008012 metal binding site [ion binding]; metal-binding site 36809008013 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809008014 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809008015 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809008016 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 36809008017 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809008018 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809008019 active site 36809008020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809008021 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 36809008022 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809008023 active site 36809008024 enoyl-CoA hydratase; Provisional; Region: PRK06190 36809008025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809008026 substrate binding site [chemical binding]; other site 36809008027 oxyanion hole (OAH) forming residues; other site 36809008028 trimer interface [polypeptide binding]; other site 36809008029 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 36809008030 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 36809008031 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 36809008032 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 36809008033 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 36809008034 DHH family; Region: DHH; pfam01368 36809008035 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 36809008036 translation initiation factor IF-2; Validated; Region: infB; PRK05306 36809008037 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 36809008038 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 36809008039 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 36809008040 G1 box; other site 36809008041 putative GEF interaction site [polypeptide binding]; other site 36809008042 GTP/Mg2+ binding site [chemical binding]; other site 36809008043 Switch I region; other site 36809008044 G2 box; other site 36809008045 G3 box; other site 36809008046 Switch II region; other site 36809008047 G4 box; other site 36809008048 G5 box; other site 36809008049 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 36809008050 Translation-initiation factor 2; Region: IF-2; pfam11987 36809008051 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 36809008052 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 36809008053 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 36809008054 heme-binding site [chemical binding]; other site 36809008055 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 36809008056 FAD binding pocket [chemical binding]; other site 36809008057 FAD binding motif [chemical binding]; other site 36809008058 phosphate binding motif [ion binding]; other site 36809008059 beta-alpha-beta structure motif; other site 36809008060 NAD binding pocket [chemical binding]; other site 36809008061 Rrf2 family protein; Region: rrf2_super; TIGR00738 36809008062 Transcriptional regulator; Region: Rrf2; cl17282 36809008063 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 36809008064 NusA N-terminal domain; Region: NusA_N; pfam08529 36809008065 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 36809008066 RNA binding site [nucleotide binding]; other site 36809008067 homodimer interface [polypeptide binding]; other site 36809008068 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 36809008069 G-X-X-G motif; other site 36809008070 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 36809008071 G-X-X-G motif; other site 36809008072 ribosome maturation protein RimP; Reviewed; Region: PRK00092 36809008073 heptamer interface [polypeptide binding]; other site 36809008074 Sm1 motif; other site 36809008075 hexamer interface [polypeptide binding]; other site 36809008076 RNA binding site [nucleotide binding]; other site 36809008077 Sm2 motif; other site 36809008078 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 36809008079 dinuclear metal binding motif [ion binding]; other site 36809008080 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 36809008081 putative hydrophobic ligand binding site [chemical binding]; other site 36809008082 protein interface [polypeptide binding]; other site 36809008083 gate; other site 36809008084 prolyl-tRNA synthetase; Provisional; Region: PRK09194 36809008085 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 36809008086 dimer interface [polypeptide binding]; other site 36809008087 motif 1; other site 36809008088 active site 36809008089 motif 2; other site 36809008090 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 36809008091 putative deacylase active site [active] 36809008092 motif 3; other site 36809008093 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 36809008094 anticodon binding site; other site 36809008095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809008096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809008097 putative substrate translocation pore; other site 36809008098 siroheme synthase; Provisional; Region: cysG; PRK10637 36809008099 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 36809008100 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 36809008101 active site 36809008102 SAM binding site [chemical binding]; other site 36809008103 homodimer interface [polypeptide binding]; other site 36809008104 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 36809008105 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 36809008106 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 36809008107 Walker A/P-loop; other site 36809008108 ATP binding site [chemical binding]; other site 36809008109 Q-loop/lid; other site 36809008110 ABC transporter signature motif; other site 36809008111 Walker B; other site 36809008112 D-loop; other site 36809008113 H-loop/switch region; other site 36809008114 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 36809008115 Walker A/P-loop; other site 36809008116 ATP binding site [chemical binding]; other site 36809008117 Q-loop/lid; other site 36809008118 ABC transporter signature motif; other site 36809008119 Walker B; other site 36809008120 D-loop; other site 36809008121 H-loop/switch region; other site 36809008122 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 36809008123 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 36809008124 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809008125 Condensation domain; Region: Condensation; cl19241 36809008126 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 36809008127 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809008128 active site 36809008129 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 36809008130 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 36809008131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809008132 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 36809008133 Enoylreductase; Region: PKS_ER; smart00829 36809008134 NAD(P) binding site [chemical binding]; other site 36809008135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809008136 short chain dehydrogenase; Region: adh_short; pfam00106 36809008137 NAD(P) binding site [chemical binding]; other site 36809008138 active site 36809008139 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 36809008140 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809008141 Transport protein; Region: actII; TIGR00833 36809008142 MMPL family; Region: MMPL; pfam03176 36809008143 MMPL family; Region: MMPL; pfam03176 36809008144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008146 MspA; Region: MspA; pfam09203 36809008147 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 36809008148 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809008149 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 36809008150 conserved cys residue [active] 36809008151 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 36809008152 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 36809008153 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 36809008154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809008155 Walker A motif; other site 36809008156 ATP binding site [chemical binding]; other site 36809008157 Walker B motif; other site 36809008158 arginine finger; other site 36809008159 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 36809008160 metal ion-dependent adhesion site (MIDAS); other site 36809008161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809008162 Coenzyme A binding pocket [chemical binding]; other site 36809008163 malate:quinone oxidoreductase; Validated; Region: PRK05257 36809008164 Predicted dehydrogenase [General function prediction only]; Region: COG0579 36809008165 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 36809008166 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809008167 PE-PPE domain; Region: PE-PPE; pfam08237 36809008168 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809008169 cobyric acid synthase; Provisional; Region: PRK00784 36809008170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809008171 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 36809008172 catalytic triad [active] 36809008173 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 36809008174 active site 36809008175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 36809008176 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 36809008177 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 36809008178 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809008179 active site 36809008180 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 36809008181 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 36809008182 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 36809008183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809008184 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 36809008185 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 36809008186 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 36809008187 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 36809008188 active site 36809008189 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 36809008190 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 36809008191 putative substrate binding region [chemical binding]; other site 36809008192 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 36809008193 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 36809008194 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 36809008195 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 36809008196 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 36809008197 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 36809008198 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 36809008199 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 36809008200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809008201 FeS/SAM binding site; other site 36809008202 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 36809008203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809008204 non-specific DNA binding site [nucleotide binding]; other site 36809008205 salt bridge; other site 36809008206 sequence-specific DNA binding site [nucleotide binding]; other site 36809008207 Cupin domain; Region: Cupin_2; cl17218 36809008208 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 36809008209 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809008210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809008211 S-adenosylmethionine binding site [chemical binding]; other site 36809008212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809008213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809008214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 36809008215 dimerization interface [polypeptide binding]; other site 36809008216 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 36809008217 EamA-like transporter family; Region: EamA; pfam00892 36809008218 EamA-like transporter family; Region: EamA; pfam00892 36809008219 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 36809008220 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 36809008221 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 36809008222 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 36809008223 hinge region; other site 36809008224 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 36809008225 putative nucleotide binding site [chemical binding]; other site 36809008226 uridine monophosphate binding site [chemical binding]; other site 36809008227 homohexameric interface [polypeptide binding]; other site 36809008228 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 36809008229 Part of AAA domain; Region: AAA_19; pfam13245 36809008230 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 36809008231 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 36809008232 hypothetical protein; Provisional; Region: PRK06547 36809008233 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 36809008234 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 36809008235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008237 putative methanogenesis marker 16 metalloprotein; Region: methan_mark_16; TIGR03287 36809008238 elongation factor Ts; Provisional; Region: tsf; PRK09377 36809008239 UBA/TS-N domain; Region: UBA; pfam00627 36809008240 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 36809008241 rRNA interaction site [nucleotide binding]; other site 36809008242 S8 interaction site; other site 36809008243 putative laminin-1 binding site; other site 36809008244 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 36809008245 Peptidase family M23; Region: Peptidase_M23; pfam01551 36809008246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008248 Predicted transcriptional regulators [Transcription]; Region: COG1733 36809008249 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809008250 Transport protein; Region: actII; TIGR00833 36809008251 MMPL family; Region: MMPL; pfam03176 36809008252 MMPL family; Region: MMPL; pfam03176 36809008253 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 36809008254 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 36809008255 active site 36809008256 DNA binding site [nucleotide binding] 36809008257 Int/Topo IB signature motif; other site 36809008258 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 36809008259 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 36809008260 FAD binding pocket [chemical binding]; other site 36809008261 FAD binding motif [chemical binding]; other site 36809008262 phosphate binding motif [ion binding]; other site 36809008263 NAD binding pocket [chemical binding]; other site 36809008264 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 36809008265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008266 Transcriptional regulator, TetR, C-terminal; Region: TetR_C_9; pfam14514 36809008267 DoxX-like family; Region: DoxX_2; pfam13564 36809008268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809008269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809008270 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 36809008271 putative dimerization interface [polypeptide binding]; other site 36809008272 Predicted membrane protein [Function unknown]; Region: COG3619 36809008273 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 36809008274 active site clefts [active] 36809008275 zinc binding site [ion binding]; other site 36809008276 dimer interface [polypeptide binding]; other site 36809008277 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 36809008278 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 36809008279 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 36809008280 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 36809008281 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 36809008282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809008283 Walker A motif; other site 36809008284 ATP binding site [chemical binding]; other site 36809008285 Walker B motif; other site 36809008286 arginine finger; other site 36809008287 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 36809008288 hypothetical protein; Reviewed; Region: PRK12497 36809008289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008290 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 36809008291 CsbD-like; Region: CsbD; pfam05532 36809008292 Predicted membrane protein [Function unknown]; Region: COG2261 36809008293 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 36809008294 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 36809008295 RNA/DNA hybrid binding site [nucleotide binding]; other site 36809008296 active site 36809008297 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 36809008298 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 36809008299 Catalytic site [active] 36809008300 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 36809008301 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 36809008302 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 36809008303 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 36809008304 RimM N-terminal domain; Region: RimM; pfam01782 36809008305 PRC-barrel domain; Region: PRC; pfam05239 36809008306 hypothetical protein; Provisional; Region: PRK02821 36809008307 G-X-X-G motif; other site 36809008308 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 36809008309 ribosomal protein S16; Region: S16; TIGR00002 36809008310 SnoaL-like domain; Region: SnoaL_4; pfam13577 36809008311 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809008312 CoenzymeA binding site [chemical binding]; other site 36809008313 subunit interaction site [polypeptide binding]; other site 36809008314 PHB binding site; other site 36809008315 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 36809008316 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 36809008317 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 36809008318 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 36809008319 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 36809008320 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 36809008321 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 36809008322 active site 36809008323 signal recognition particle protein; Provisional; Region: PRK10867 36809008324 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 36809008325 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 36809008326 P loop; other site 36809008327 GTP binding site [chemical binding]; other site 36809008328 Signal peptide binding domain; Region: SRP_SPB; pfam02978 36809008329 PII uridylyl-transferase; Provisional; Region: PRK03381 36809008330 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 36809008331 metal binding triad; other site 36809008332 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 36809008333 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 36809008334 Zn2+ binding site [ion binding]; other site 36809008335 Mg2+ binding site [ion binding]; other site 36809008336 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 36809008337 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 36809008338 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 36809008339 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 36809008340 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 36809008341 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 36809008342 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 36809008343 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 36809008344 isopentenyl-diphosphate delta-isomerase, type 2; Region: IPP_isom_2; TIGR02151 36809008345 homotetramer interface [polypeptide binding]; other site 36809008346 FMN binding site [chemical binding]; other site 36809008347 homodimer contacts [polypeptide binding]; other site 36809008348 putative active site [active] 36809008349 putative substrate binding site [chemical binding]; other site 36809008350 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 36809008351 catalytic residues [active] 36809008352 Sulfite exporter TauE/SafE; Region: TauE; cl19196 36809008353 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 36809008354 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 36809008355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809008356 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 36809008357 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 36809008358 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 36809008359 ABC transporter signature motif; other site 36809008360 Walker B; other site 36809008361 D-loop; other site 36809008362 H-loop/switch region; other site 36809008363 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 36809008364 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 36809008365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809008366 active site 36809008367 phosphorylation site [posttranslational modification] 36809008368 intermolecular recognition site; other site 36809008369 dimerization interface [polypeptide binding]; other site 36809008370 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809008371 DNA binding site [nucleotide binding] 36809008372 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 36809008373 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 36809008374 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 36809008375 Ligand Binding Site [chemical binding]; other site 36809008376 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 36809008377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809008378 dimer interface [polypeptide binding]; other site 36809008379 phosphorylation site [posttranslational modification] 36809008380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809008381 ATP binding site [chemical binding]; other site 36809008382 Mg2+ binding site [ion binding]; other site 36809008383 G-X-G motif; other site 36809008384 K+-transporting ATPase, c chain; Region: KdpC; cl00944 36809008385 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 36809008386 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 36809008387 Soluble P-type ATPase [General function prediction only]; Region: COG4087 36809008388 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 36809008389 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 36809008390 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 36809008391 DNA binding site [nucleotide binding] 36809008392 catalytic residue [active] 36809008393 H2TH interface [polypeptide binding]; other site 36809008394 putative catalytic residues [active] 36809008395 turnover-facilitating residue; other site 36809008396 intercalation triad [nucleotide binding]; other site 36809008397 8OG recognition residue [nucleotide binding]; other site 36809008398 putative reading head residues; other site 36809008399 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 36809008400 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 36809008401 ribonuclease III; Reviewed; Region: rnc; PRK00102 36809008402 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 36809008403 dimerization interface [polypeptide binding]; other site 36809008404 active site 36809008405 metal binding site [ion binding]; metal-binding site 36809008406 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 36809008407 dsRNA binding site [nucleotide binding]; other site 36809008408 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 36809008409 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 36809008410 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 36809008411 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 36809008412 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 36809008413 active site 36809008414 (T/H)XGH motif; other site 36809008415 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 36809008416 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 36809008417 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 36809008418 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809008419 lipase chaperone; Provisional; Region: PRK01294 36809008420 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 36809008421 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809008422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809008423 S-adenosylmethionine binding site [chemical binding]; other site 36809008424 pyruvate carboxylase; Reviewed; Region: PRK12999 36809008425 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 36809008426 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809008427 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 36809008428 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 36809008429 active site 36809008430 catalytic residues [active] 36809008431 metal binding site [ion binding]; metal-binding site 36809008432 homodimer binding site [polypeptide binding]; other site 36809008433 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 36809008434 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 36809008435 carboxyltransferase (CT) interaction site; other site 36809008436 biotinylation site [posttranslational modification]; other site 36809008437 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 36809008438 putative active site [active] 36809008439 redox center [active] 36809008440 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 36809008441 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 36809008442 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 36809008443 catalytic residues [active] 36809008444 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809008445 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809008446 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 36809008447 Cutinase; Region: Cutinase; pfam01083 36809008448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008450 Divergent 4Fe-4S mono-cluster; Region: Fer4_19; cl01443 36809008451 Cytochrome P450; Region: p450; cl12078 36809008452 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 36809008453 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 36809008454 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 36809008455 generic binding surface II; other site 36809008456 ssDNA binding site; other site 36809008457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809008458 ATP binding site [chemical binding]; other site 36809008459 putative Mg++ binding site [ion binding]; other site 36809008460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809008461 nucleotide binding region [chemical binding]; other site 36809008462 ATP-binding site [chemical binding]; other site 36809008463 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 36809008464 DAK2 domain; Region: Dak2; pfam02734 36809008465 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 36809008466 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 36809008467 enoyl-CoA hydratase; Provisional; Region: PRK06688 36809008468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809008469 substrate binding site [chemical binding]; other site 36809008470 oxyanion hole (OAH) forming residues; other site 36809008471 trimer interface [polypeptide binding]; other site 36809008472 Secretory lipase; Region: LIP; pfam03583 36809008473 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 36809008474 ligand binding site [chemical binding]; other site 36809008475 active site 36809008476 UGI interface [polypeptide binding]; other site 36809008477 catalytic site [active] 36809008478 thiamine monophosphate kinase; Provisional; Region: PRK05731 36809008479 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 36809008480 ATP binding site [chemical binding]; other site 36809008481 dimerization interface [polypeptide binding]; other site 36809008482 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 36809008483 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 36809008484 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 36809008485 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 36809008486 cystathionine gamma-lyase; Validated; Region: PRK07582 36809008487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809008488 catalytic residue [active] 36809008489 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 36809008490 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 36809008491 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 36809008492 Guanylyl transferase CofC like; Region: CofC; cl17472 36809008493 polyphosphate kinase; Provisional; Region: PRK05443 36809008494 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 36809008495 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 36809008496 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 36809008497 putative domain interface [polypeptide binding]; other site 36809008498 putative active site [active] 36809008499 catalytic site [active] 36809008500 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 36809008501 putative domain interface [polypeptide binding]; other site 36809008502 putative active site [active] 36809008503 catalytic site [active] 36809008504 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 36809008505 active site 36809008506 Ap6A binding site [chemical binding]; other site 36809008507 nudix motif; other site 36809008508 metal binding site [ion binding]; metal-binding site 36809008509 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809008510 catalytic core [active] 36809008511 histone-like DNA-binding protein HU; Region: HU; cd13831 36809008512 dimer interface [polypeptide binding]; other site 36809008513 DNA binding site [nucleotide binding] 36809008514 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 36809008515 substrate binding site [chemical binding]; other site 36809008516 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 36809008517 substrate binding site [chemical binding]; other site 36809008518 ligand binding site [chemical binding]; other site 36809008519 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 36809008520 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809008521 Bacterial transcriptional regulator; Region: IclR; pfam01614 36809008522 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 36809008523 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 36809008524 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 36809008525 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 36809008526 active site 36809008527 HIGH motif; other site 36809008528 KMSKS motif; other site 36809008529 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 36809008530 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 36809008531 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 36809008532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008533 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809008534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809008535 putative substrate translocation pore; other site 36809008536 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809008537 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 36809008538 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 36809008539 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 36809008540 ligand binding site [chemical binding]; other site 36809008541 NAD binding site [chemical binding]; other site 36809008542 dimerization interface [polypeptide binding]; other site 36809008543 catalytic site [active] 36809008544 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 36809008545 putative L-serine binding site [chemical binding]; other site 36809008546 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809008547 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809008548 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 36809008549 putative NAD(P) binding site [chemical binding]; other site 36809008550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809008551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809008552 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 36809008553 putative dimerization interface [polypeptide binding]; other site 36809008554 Protein of unknown function, DUF417; Region: DUF417; cl01162 36809008555 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 36809008556 dimer interface [polypeptide binding]; other site 36809008557 FMN binding site [chemical binding]; other site 36809008558 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 36809008559 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809008560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008564 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809008565 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809008566 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809008567 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809008568 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 36809008569 acyl-activating enzyme (AAE) consensus motif; other site 36809008570 AMP binding site [chemical binding]; other site 36809008571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809008572 Condensation domain; Region: Condensation; cl19241 36809008573 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809008574 Condensation domain; Region: Condensation; cl19241 36809008575 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809008576 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 36809008577 acyl-activating enzyme (AAE) consensus motif; other site 36809008578 AMP binding site [chemical binding]; other site 36809008579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809008580 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 36809008581 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 36809008582 putative NAD(P) binding site [chemical binding]; other site 36809008583 active site 36809008584 putative substrate binding site [chemical binding]; other site 36809008585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809008586 dimerization interface [polypeptide binding]; other site 36809008587 putative DNA binding site [nucleotide binding]; other site 36809008588 putative Zn2+ binding site [ion binding]; other site 36809008589 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809008590 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 36809008591 ketol-acid reductoisomerase; Provisional; Region: PRK05479 36809008592 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 36809008593 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 36809008594 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 36809008595 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 36809008596 putative valine binding site [chemical binding]; other site 36809008597 dimer interface [polypeptide binding]; other site 36809008598 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 36809008599 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 36809008600 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 36809008601 PYR/PP interface [polypeptide binding]; other site 36809008602 dimer interface [polypeptide binding]; other site 36809008603 TPP binding site [chemical binding]; other site 36809008604 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 36809008605 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 36809008606 TPP-binding site [chemical binding]; other site 36809008607 dimer interface [polypeptide binding]; other site 36809008608 Bacterial PH domain; Region: bPH_6; pfam10756 36809008609 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 36809008610 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809008611 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809008612 inhibitor-cofactor binding pocket; inhibition site 36809008613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809008614 catalytic residue [active] 36809008615 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809008616 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 36809008617 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 36809008618 NAD(P) binding site [chemical binding]; other site 36809008619 catalytic residues [active] 36809008620 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809008621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809008622 dimerization interface [polypeptide binding]; other site 36809008623 putative DNA binding site [nucleotide binding]; other site 36809008624 putative Zn2+ binding site [ion binding]; other site 36809008625 Squalene epoxidase; Region: SE; cl17314 36809008626 hypothetical protein; Provisional; Region: PRK06847 36809008627 Amino acid permease; Region: AA_permease_2; pfam13520 36809008628 Predicted membrane protein [Function unknown]; Region: COG2259 36809008629 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 36809008630 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 36809008631 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 36809008632 GatB domain; Region: GatB_Yqey; smart00845 36809008633 6-phosphofructokinase; Provisional; Region: PRK03202 36809008634 active site 36809008635 ADP/pyrophosphate binding site [chemical binding]; other site 36809008636 dimerization interface [polypeptide binding]; other site 36809008637 allosteric effector site; other site 36809008638 fructose-1,6-bisphosphate binding site; other site 36809008639 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 36809008640 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809008641 substrate binding pocket [chemical binding]; other site 36809008642 catalytic triad [active] 36809008643 Protein of unknown function, DUF417; Region: DUF417; cl01162 36809008644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809008645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809008646 active site 36809008647 phosphorylation site [posttranslational modification] 36809008648 intermolecular recognition site; other site 36809008649 dimerization interface [polypeptide binding]; other site 36809008650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809008651 DNA binding site [nucleotide binding] 36809008652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809008653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809008654 dimerization interface [polypeptide binding]; other site 36809008655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809008656 dimer interface [polypeptide binding]; other site 36809008657 phosphorylation site [posttranslational modification] 36809008658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809008659 ATP binding site [chemical binding]; other site 36809008660 Mg2+ binding site [ion binding]; other site 36809008661 G-X-G motif; other site 36809008662 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 36809008663 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 36809008664 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 36809008665 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 36809008666 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 36809008667 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 36809008668 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 36809008669 nucleotide binding pocket [chemical binding]; other site 36809008670 K-X-D-G motif; other site 36809008671 catalytic site [active] 36809008672 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 36809008673 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 36809008674 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 36809008675 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 36809008676 Dimer interface [polypeptide binding]; other site 36809008677 BRCT sequence motif; other site 36809008678 YjbR; Region: YjbR; pfam04237 36809008679 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 36809008680 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 36809008681 enoyl-CoA hydratase; Provisional; Region: PRK06142 36809008682 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809008683 substrate binding site [chemical binding]; other site 36809008684 oxyanion hole (OAH) forming residues; other site 36809008685 trimer interface [polypeptide binding]; other site 36809008686 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 36809008687 putative FMN binding site [chemical binding]; other site 36809008688 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 36809008689 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 36809008690 Sulfate transporter family; Region: Sulfate_transp; cl19250 36809008691 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 36809008692 homodimer interface [polypeptide binding]; other site 36809008693 putative substrate binding pocket [chemical binding]; other site 36809008694 diiron center [ion binding]; other site 36809008695 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 36809008696 active site 36809008697 catalytic triad [active] 36809008698 oxyanion hole [active] 36809008699 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 36809008700 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 36809008701 Ligand Binding Site [chemical binding]; other site 36809008702 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 36809008703 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809008704 catalytic residue [active] 36809008705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 36809008706 putative acyl-acceptor binding pocket; other site 36809008707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 36809008708 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 36809008709 NADH(P)-binding; Region: NAD_binding_10; pfam13460 36809008710 NAD(P) binding site [chemical binding]; other site 36809008711 active site 36809008712 AAA ATPase domain; Region: AAA_16; pfam13191 36809008713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809008714 DNA binding residues [nucleotide binding] 36809008715 dimerization interface [polypeptide binding]; other site 36809008716 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 36809008717 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 36809008718 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 36809008719 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 36809008720 Ligand binding site [chemical binding]; other site 36809008721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809008722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809008723 S-adenosylmethionine binding site [chemical binding]; other site 36809008724 Uncharacterized conserved protein [Function unknown]; Region: COG1543 36809008725 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 36809008726 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 36809008727 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809008728 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 36809008729 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 36809008730 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809008731 acyl-activating enzyme (AAE) consensus motif; other site 36809008732 AMP binding site [chemical binding]; other site 36809008733 active site 36809008734 CoA binding site [chemical binding]; other site 36809008735 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809008736 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 36809008737 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 36809008738 putative NAD(P) binding site [chemical binding]; other site 36809008739 active site 36809008740 putative substrate binding site [chemical binding]; other site 36809008741 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809008742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809008743 putative DNA binding site [nucleotide binding]; other site 36809008744 putative Zn2+ binding site [ion binding]; other site 36809008745 AsnC family; Region: AsnC_trans_reg; pfam01037 36809008746 AzlC protein; Region: AzlC; cl00570 36809008747 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 36809008748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008750 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 36809008751 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 36809008752 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 36809008753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809008754 dimerization interface [polypeptide binding]; other site 36809008755 putative DNA binding site [nucleotide binding]; other site 36809008756 putative Zn2+ binding site [ion binding]; other site 36809008757 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 36809008758 putative hydrophobic ligand binding site [chemical binding]; other site 36809008759 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809008760 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 36809008761 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 36809008762 trimer interface [polypeptide binding]; other site 36809008763 active site 36809008764 substrate binding site [chemical binding]; other site 36809008765 CoA binding site [chemical binding]; other site 36809008766 FOG: WD40-like repeat [Function unknown]; Region: COG1520 36809008767 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 36809008768 Trp docking motif [polypeptide binding]; other site 36809008769 active site 36809008770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809008771 S-adenosylmethionine binding site [chemical binding]; other site 36809008772 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 36809008773 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809008774 substrate binding site [chemical binding]; other site 36809008775 oxyanion hole (OAH) forming residues; other site 36809008776 trimer interface [polypeptide binding]; other site 36809008777 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 36809008778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809008779 Walker A/P-loop; other site 36809008780 ATP binding site [chemical binding]; other site 36809008781 Q-loop/lid; other site 36809008782 ABC transporter signature motif; other site 36809008783 Walker B; other site 36809008784 D-loop; other site 36809008785 H-loop/switch region; other site 36809008786 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 36809008787 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809008788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809008789 sequence-specific DNA binding site [nucleotide binding]; other site 36809008790 salt bridge; other site 36809008791 Predicted membrane protein [Function unknown]; Region: COG2364 36809008792 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 36809008793 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 36809008794 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 36809008795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809008796 DNA-binding site [nucleotide binding]; DNA binding site 36809008797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809008798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809008799 homodimer interface [polypeptide binding]; other site 36809008800 catalytic residue [active] 36809008801 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 36809008802 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 36809008803 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 36809008804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809008805 motif II; other site 36809008806 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 36809008807 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 36809008808 D-pathway; other site 36809008809 Putative ubiquinol binding site [chemical binding]; other site 36809008810 Low-spin heme (heme b) binding site [chemical binding]; other site 36809008811 Putative water exit pathway; other site 36809008812 Binuclear center (heme o3/CuB) [ion binding]; other site 36809008813 K-pathway; other site 36809008814 Putative proton exit pathway; other site 36809008815 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 36809008816 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 36809008817 intersubunit interface [polypeptide binding]; other site 36809008818 YCII-related domain; Region: YCII; cl00999 36809008819 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809008820 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809008821 hydrophobic ligand binding site; other site 36809008822 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 36809008823 EamA-like transporter family; Region: EamA; pfam00892 36809008824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008826 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 36809008827 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809008828 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 36809008829 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 36809008830 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 36809008831 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 36809008832 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 36809008833 putative NAD(P) binding site [chemical binding]; other site 36809008834 putative substrate binding site [chemical binding]; other site 36809008835 catalytic Zn binding site [ion binding]; other site 36809008836 structural Zn binding site [ion binding]; other site 36809008837 dimer interface [polypeptide binding]; other site 36809008838 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 36809008839 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 36809008840 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 36809008841 dimer interface [polypeptide binding]; other site 36809008842 putative radical transfer pathway; other site 36809008843 diiron center [ion binding]; other site 36809008844 tyrosyl radical; other site 36809008845 short chain dehydrogenase; Provisional; Region: PRK07825 36809008846 classical (c) SDRs; Region: SDR_c; cd05233 36809008847 NAD(P) binding site [chemical binding]; other site 36809008848 active site 36809008849 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 36809008850 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809008851 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 36809008852 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809008853 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 36809008854 SCP-2 sterol transfer family; Region: SCP2; cl01225 36809008855 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 36809008856 dimerization interface [polypeptide binding]; other site 36809008857 substrate binding pocket [chemical binding]; other site 36809008858 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 36809008859 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 36809008860 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 36809008861 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 36809008862 Class I ribonucleotide reductase; Region: RNR_I; cd01679 36809008863 active site 36809008864 dimer interface [polypeptide binding]; other site 36809008865 catalytic residues [active] 36809008866 effector binding site; other site 36809008867 R2 peptide binding site; other site 36809008868 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 36809008869 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 36809008870 catalytic residues [active] 36809008871 metabolite-proton symporter; Region: 2A0106; TIGR00883 36809008872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809008873 putative substrate translocation pore; other site 36809008874 Predicted flavoprotein [General function prediction only]; Region: COG0431 36809008875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008877 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 36809008878 homodimer interface [polypeptide binding]; other site 36809008879 NAD binding pocket [chemical binding]; other site 36809008880 ATP binding pocket [chemical binding]; other site 36809008881 Mg binding site [ion binding]; other site 36809008882 active-site loop [active] 36809008883 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 36809008884 classical (c) SDRs; Region: SDR_c; cd05233 36809008885 NAD(P) binding site [chemical binding]; other site 36809008886 active site 36809008887 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 36809008888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008890 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809008891 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 36809008892 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 36809008893 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 36809008894 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 36809008895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809008896 short chain dehydrogenase; Provisional; Region: PRK12744 36809008897 NAD(P) binding site [chemical binding]; other site 36809008898 active site 36809008899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809008900 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809008901 NAD(P) binding site [chemical binding]; other site 36809008902 active site 36809008903 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 36809008904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809008905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809008906 DNA binding residues [nucleotide binding] 36809008907 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 36809008908 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 36809008909 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 36809008910 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 36809008911 Putative zinc-finger; Region: zf-HC2; pfam13490 36809008912 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 36809008913 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 36809008914 catalytic triad [active] 36809008915 conserved cis-peptide bond; other site 36809008916 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 36809008917 Na binding site [ion binding]; other site 36809008918 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 36809008919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809008920 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 36809008921 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 36809008922 acyl-activating enzyme (AAE) consensus motif; other site 36809008923 putative AMP binding site [chemical binding]; other site 36809008924 putative active site [active] 36809008925 acyl-activating enzyme (AAE) consensus motif; other site 36809008926 putative CoA binding site [chemical binding]; other site 36809008927 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 36809008928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008930 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 36809008931 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 36809008932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809008933 NAD(P) binding site [chemical binding]; other site 36809008934 active site 36809008935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809008936 short chain dehydrogenase; Region: adh_short; pfam00106 36809008937 NAD(P) binding site [chemical binding]; other site 36809008938 active site 36809008939 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 36809008940 NAD+ binding site [chemical binding]; other site 36809008941 substrate binding site [chemical binding]; other site 36809008942 Zn binding site [ion binding]; other site 36809008943 SpoIIAA-like; Region: SpoIIAA-like; pfam11964 36809008944 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 36809008945 Transcription factor WhiB; Region: Whib; pfam02467 36809008946 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 36809008947 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809008948 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809008949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809008950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809008951 putative substrate translocation pore; other site 36809008952 phosphoglucomutase; Validated; Region: PRK07564 36809008953 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 36809008954 active site 36809008955 substrate binding site [chemical binding]; other site 36809008956 metal binding site [ion binding]; metal-binding site 36809008957 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 36809008958 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 36809008959 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809008960 substrate binding pocket [chemical binding]; other site 36809008961 catalytic triad [active] 36809008962 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 36809008963 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809008964 substrate binding pocket [chemical binding]; other site 36809008965 catalytic triad [active] 36809008966 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 36809008967 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 36809008968 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809008969 dimer interface [polypeptide binding]; other site 36809008970 active site 36809008971 Predicted transcriptional regulators [Transcription]; Region: COG1733 36809008972 dimerization interface [polypeptide binding]; other site 36809008973 putative DNA binding site [nucleotide binding]; other site 36809008974 putative Zn2+ binding site [ion binding]; other site 36809008975 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 36809008976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809008977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809008978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 36809008979 dimerization interface [polypeptide binding]; other site 36809008980 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 36809008981 nucleoside/Zn binding site; other site 36809008982 dimer interface [polypeptide binding]; other site 36809008983 catalytic motif [active] 36809008984 Transcriptional regulator [Transcription]; Region: LytR; COG1316 36809008985 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 36809008986 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 36809008987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809008988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809008989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809008990 S-adenosylmethionine binding site [chemical binding]; other site 36809008991 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 36809008992 anti sigma factor interaction site; other site 36809008993 regulatory phosphorylation site [posttranslational modification]; other site 36809008994 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 36809008995 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 36809008996 putative dimer interface [polypeptide binding]; other site 36809008997 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 36809008998 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809008999 DNA binding residues [nucleotide binding] 36809009000 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 36809009001 nudix motif; other site 36809009002 acetolactate synthase; Reviewed; Region: PRK08322 36809009003 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 36809009004 dimer interface [polypeptide binding]; other site 36809009005 PYR/PP interface [polypeptide binding]; other site 36809009006 TPP binding site [chemical binding]; other site 36809009007 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 36809009008 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 36809009009 TPP-binding site [chemical binding]; other site 36809009010 dimer interface [polypeptide binding]; other site 36809009011 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 36809009012 NAD(P) binding site [chemical binding]; other site 36809009013 catalytic residues [active] 36809009014 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 36809009015 SmpB-tmRNA interface; other site 36809009016 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 36809009017 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 36809009018 FtsX-like permease family; Region: FtsX; pfam02687 36809009019 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 36809009020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809009021 Walker A/P-loop; other site 36809009022 ATP binding site [chemical binding]; other site 36809009023 Q-loop/lid; other site 36809009024 ABC transporter signature motif; other site 36809009025 Walker B; other site 36809009026 D-loop; other site 36809009027 H-loop/switch region; other site 36809009028 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 36809009029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 36809009030 peptide chain release factor 2; Validated; Region: prfB; PRK00578 36809009031 This domain is found in peptide chain release factors; Region: PCRF; smart00937 36809009032 RF-1 domain; Region: RF-1; pfam00472 36809009033 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809009034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809009035 putative Zn2+ binding site [ion binding]; other site 36809009036 putative DNA binding site [nucleotide binding]; other site 36809009037 Bacterial transcriptional regulator; Region: IclR; pfam01614 36809009038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809009039 active site 36809009040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009041 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809009042 active site 36809009043 ferredoxin-NADP+ reductase; Region: PLN02852 36809009044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009045 hypothetical protein; Provisional; Region: PRK06834 36809009046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009047 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 36809009048 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 36809009049 active site 36809009050 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009051 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809009052 active site 36809009053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809009055 active site 36809009056 acyl-CoA synthetase; Validated; Region: PRK07788 36809009057 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809009058 AMP binding site [chemical binding]; other site 36809009059 active site 36809009060 acyl-activating enzyme (AAE) consensus motif; other site 36809009061 CoA binding site [chemical binding]; other site 36809009062 Clp amino terminal domain; Region: Clp_N; pfam02861 36809009063 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809009064 Cupin domain; Region: Cupin_2; cl17218 36809009065 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 36809009066 hypothetical protein; Validated; Region: PRK00068 36809009067 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 36809009068 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 36809009069 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 36809009070 Protein of unknown function, DUF393; Region: DUF393; cl01136 36809009071 Uncharacterized conserved protein [Function unknown]; Region: COG5282 36809009072 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 36809009073 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809009074 active site 36809009075 ATP binding site [chemical binding]; other site 36809009076 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809009077 active site 36809009078 ATP binding site [chemical binding]; other site 36809009079 Domain of unknown function (DUF336); Region: DUF336; cl01249 36809009080 short chain dehydrogenase; Provisional; Region: PRK09291 36809009081 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 36809009082 NADP binding site [chemical binding]; other site 36809009083 active site 36809009084 steroid binding site; other site 36809009085 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809009086 active site 36809009087 ATP binding site [chemical binding]; other site 36809009088 Transcription factor WhiB; Region: Whib; pfam02467 36809009089 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 36809009090 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 36809009091 Part of AAA domain; Region: AAA_19; pfam13245 36809009092 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 36809009093 HRDC domain; Region: HRDC; pfam00570 36809009094 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 36809009095 catalytic residues [active] 36809009096 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 36809009097 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 36809009098 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 36809009099 putative NADH binding site [chemical binding]; other site 36809009100 putative active site [active] 36809009101 nudix motif; other site 36809009102 putative metal binding site [ion binding]; other site 36809009103 Ion channel; Region: Ion_trans_2; pfam07885 36809009104 TrkA-N domain; Region: TrkA_N; pfam02254 36809009105 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 36809009106 Part of AAA domain; Region: AAA_19; pfam13245 36809009107 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 36809009108 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 36809009109 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 36809009110 Part of AAA domain; Region: AAA_19; pfam13245 36809009111 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 36809009112 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009113 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809009114 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 36809009115 catalytic site [active] 36809009116 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 36809009117 active site 36809009118 DNA binding site [nucleotide binding] 36809009119 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 36809009120 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 36809009121 putative active site [active] 36809009122 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 36809009123 putative active site [active] 36809009124 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 36809009125 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 36809009126 active site 36809009127 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 36809009128 DNA binding site [nucleotide binding] 36809009129 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 36809009130 nitrite reductase subunit NirD; Provisional; Region: PRK14989 36809009131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809009133 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 36809009134 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 36809009135 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 36809009136 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 36809009137 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 36809009138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809009139 putative substrate translocation pore; other site 36809009140 TIGR02569 family protein; Region: TIGR02569_actnb 36809009141 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 36809009142 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 36809009143 ATP binding site [chemical binding]; other site 36809009144 substrate interface [chemical binding]; other site 36809009145 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 36809009146 active site residue [active] 36809009147 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 36809009148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809009149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809009150 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 36809009151 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809009152 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 36809009153 dinuclear metal binding motif [ion binding]; other site 36809009154 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 36809009155 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 36809009156 ATP binding site [chemical binding]; other site 36809009157 Mg++ binding site [ion binding]; other site 36809009158 motif III; other site 36809009159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809009160 nucleotide binding region [chemical binding]; other site 36809009161 ATP-binding site [chemical binding]; other site 36809009162 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 36809009163 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 36809009164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 36809009165 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809009166 P-loop; other site 36809009167 Magnesium ion binding site [ion binding]; other site 36809009168 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809009169 catalytic core [active] 36809009170 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 36809009171 putative acetyltransferase; Provisional; Region: PRK03624 36809009172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809009173 Coenzyme A binding pocket [chemical binding]; other site 36809009174 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 36809009175 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 36809009176 Transcription factor WhiB; Region: Whib; pfam02467 36809009177 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 36809009178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 36809009179 Histidine kinase; Region: HisKA_2; pfam07568 36809009180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809009181 ATP binding site [chemical binding]; other site 36809009182 Mg2+ binding site [ion binding]; other site 36809009183 G-X-G motif; other site 36809009184 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 36809009185 carboxyltransferase (CT) interaction site; other site 36809009186 biotinylation site [posttranslational modification]; other site 36809009187 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 36809009188 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 36809009189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809009190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809009191 DNA binding residues [nucleotide binding] 36809009192 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 36809009193 putative deacylase active site [active] 36809009194 Uncharacterized conserved protein [Function unknown]; Region: COG2135 36809009195 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 36809009196 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 36809009197 hinge; other site 36809009198 active site 36809009199 Predicted GTPases [General function prediction only]; Region: COG1162 36809009200 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 36809009201 GTPase/Zn-binding domain interface [polypeptide binding]; other site 36809009202 GTP/Mg2+ binding site [chemical binding]; other site 36809009203 G4 box; other site 36809009204 G5 box; other site 36809009205 G1 box; other site 36809009206 Switch I region; other site 36809009207 G2 box; other site 36809009208 G3 box; other site 36809009209 Switch II region; other site 36809009210 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 36809009211 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 36809009212 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 36809009213 putative di-iron ligands [ion binding]; other site 36809009214 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 36809009215 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 36809009216 FAD binding pocket [chemical binding]; other site 36809009217 FAD binding motif [chemical binding]; other site 36809009218 phosphate binding motif [ion binding]; other site 36809009219 beta-alpha-beta structure motif; other site 36809009220 NAD binding pocket [chemical binding]; other site 36809009221 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809009222 catalytic loop [active] 36809009223 iron binding site [ion binding]; other site 36809009224 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 36809009225 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 36809009226 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 36809009227 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 36809009228 active site 36809009229 catalytic residues [active] 36809009230 metal binding site [ion binding]; metal-binding site 36809009231 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 36809009232 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 36809009233 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 36809009234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809009235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809009236 putative substrate translocation pore; other site 36809009237 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809009238 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009239 Domain of unknown function (DUF955); Region: DUF955; cl01076 36809009240 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 36809009241 Transport protein; Region: actII; TIGR00833 36809009242 MMPL family; Region: MMPL; pfam03176 36809009243 MMPL family; Region: MMPL; pfam03176 36809009244 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809009245 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009246 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809009247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809009248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809009249 Putative cyclase; Region: Cyclase; pfam04199 36809009250 Putative cyclase; Region: Cyclase; cl00814 36809009251 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809009252 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809009253 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 36809009254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809009255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809009256 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 36809009257 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 36809009258 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 36809009259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809009260 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 36809009261 Acid Phosphatase; Region: Acid_PPase; cl17256 36809009262 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 36809009263 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 36809009264 active site 36809009265 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 36809009266 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 36809009267 active site 36809009268 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 36809009269 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809009270 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 36809009271 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 36809009272 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009273 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809009274 active site 36809009275 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009276 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809009277 active site 36809009278 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809009279 acyl-CoA synthetase; Validated; Region: PRK05850 36809009280 acyl-activating enzyme (AAE) consensus motif; other site 36809009281 active site 36809009282 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 36809009283 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 36809009284 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 36809009285 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809009286 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 36809009287 CoenzymeA binding site [chemical binding]; other site 36809009288 subunit interaction site [polypeptide binding]; other site 36809009289 PHB binding site; other site 36809009290 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 36809009291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809009292 DNA-binding site [nucleotide binding]; DNA binding site 36809009293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809009294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809009295 homodimer interface [polypeptide binding]; other site 36809009296 catalytic residue [active] 36809009297 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 36809009298 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 36809009299 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809009300 active site 36809009301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809009302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809009303 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809009304 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009305 active site 36809009306 lipoprotein LpqB; Provisional; Region: PRK13616 36809009307 Sporulation and spore germination; Region: Germane; pfam10646 36809009308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 36809009309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809009310 dimerization interface [polypeptide binding]; other site 36809009311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809009312 dimer interface [polypeptide binding]; other site 36809009313 phosphorylation site [posttranslational modification] 36809009314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809009315 ATP binding site [chemical binding]; other site 36809009316 Mg2+ binding site [ion binding]; other site 36809009317 G-X-G motif; other site 36809009318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809009319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809009320 active site 36809009321 phosphorylation site [posttranslational modification] 36809009322 intermolecular recognition site; other site 36809009323 dimerization interface [polypeptide binding]; other site 36809009324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809009325 DNA binding site [nucleotide binding] 36809009326 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809009327 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 36809009328 acyl-activating enzyme (AAE) consensus motif; other site 36809009329 AMP binding site [chemical binding]; other site 36809009330 active site 36809009331 CoA binding site [chemical binding]; other site 36809009332 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 36809009333 MgtC family; Region: MgtC; pfam02308 36809009334 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 36809009335 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 36809009336 TMP-binding site; other site 36809009337 ATP-binding site [chemical binding]; other site 36809009338 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 36809009339 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 36809009340 homotetramer interface [polypeptide binding]; other site 36809009341 ligand binding site [chemical binding]; other site 36809009342 catalytic site [active] 36809009343 NAD binding site [chemical binding]; other site 36809009344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809009345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809009346 Rubredoxin [Energy production and conversion]; Region: COG1773 36809009347 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 36809009348 iron binding site [ion binding]; other site 36809009349 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 36809009350 Di-iron ligands [ion binding]; other site 36809009351 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809009352 amino acid transporter; Region: 2A0306; TIGR00909 36809009353 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 36809009354 Cation efflux family; Region: Cation_efflux; pfam01545 36809009355 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 36809009356 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 36809009357 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 36809009358 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 36809009359 active site 36809009360 substrate binding site [chemical binding]; other site 36809009361 metal binding site [ion binding]; metal-binding site 36809009362 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 36809009363 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 36809009364 Transcription factor WhiB; Region: Whib; pfam02467 36809009365 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 36809009366 dimer interface [polypeptide binding]; other site 36809009367 substrate binding site [chemical binding]; other site 36809009368 phosphate binding site [ion binding]; other site 36809009369 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 36809009370 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 36809009371 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 36809009372 FMN binding site [chemical binding]; other site 36809009373 dimer interface [polypeptide binding]; other site 36809009374 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 36809009375 nudix motif; other site 36809009376 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 36809009377 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 36809009378 active site 36809009379 Substrate binding site; other site 36809009380 Mg++ binding site; other site 36809009381 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 36809009382 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 36809009383 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 36809009384 Probable Catalytic site; other site 36809009385 metal-binding site 36809009386 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 36809009387 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 36809009388 NADP binding site [chemical binding]; other site 36809009389 active site 36809009390 putative substrate binding site [chemical binding]; other site 36809009391 Transcriptional regulator [Transcription]; Region: LytR; COG1316 36809009392 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 36809009393 TIGR03089 family protein; Region: TIGR03089 36809009394 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 36809009395 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 36809009396 putative active site [active] 36809009397 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009398 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 36809009399 FAD binding site [chemical binding]; other site 36809009400 homotetramer interface [polypeptide binding]; other site 36809009401 substrate binding pocket [chemical binding]; other site 36809009402 catalytic base [active] 36809009403 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 36809009404 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 36809009405 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809009406 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 36809009407 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 36809009408 active site 36809009409 iron coordination sites [ion binding]; other site 36809009410 substrate binding pocket [chemical binding]; other site 36809009411 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 36809009412 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 36809009413 NADP binding site [chemical binding]; other site 36809009414 dimer interface [polypeptide binding]; other site 36809009415 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 36809009416 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 36809009417 Bacterial PH domain; Region: bPH_2; pfam03703 36809009418 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 36809009419 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 36809009420 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 36809009421 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 36809009422 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 36809009423 acyl-CoA synthetase; Provisional; Region: PRK13388 36809009424 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809009425 acyl-activating enzyme (AAE) consensus motif; other site 36809009426 AMP binding site [chemical binding]; other site 36809009427 active site 36809009428 CoA binding site [chemical binding]; other site 36809009429 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809009430 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809009431 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 36809009432 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809009433 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809009434 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 36809009435 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 36809009436 active site 36809009437 dimer interface [polypeptide binding]; other site 36809009438 GntP family permease; Region: GntP_permease; pfam02447 36809009439 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 36809009440 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 36809009441 ATP-binding site [chemical binding]; other site 36809009442 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809009443 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 36809009444 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809009445 active site 36809009446 Phosphotransferase enzyme family; Region: APH; pfam01636 36809009447 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 36809009448 active site 36809009449 substrate binding site [chemical binding]; other site 36809009450 ATP binding site [chemical binding]; other site 36809009451 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 36809009452 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809009453 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 36809009454 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 36809009455 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 36809009456 active site residue [active] 36809009457 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 36809009458 active site residue [active] 36809009459 Fe-S metabolizm associated domain; Region: SufE; cl00951 36809009460 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 36809009461 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 36809009462 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 36809009463 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 36809009464 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 36809009465 carboxyltransferase (CT) interaction site; other site 36809009466 biotinylation site [posttranslational modification]; other site 36809009467 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 36809009468 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809009469 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809009470 inhibitor-cofactor binding pocket; inhibition site 36809009471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809009472 catalytic residue [active] 36809009473 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809009474 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 36809009475 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 36809009476 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 36809009477 tetrameric interface [polypeptide binding]; other site 36809009478 NAD binding site [chemical binding]; other site 36809009479 catalytic residues [active] 36809009480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809009481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809009482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809009483 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 36809009484 ATP binding site [chemical binding]; other site 36809009485 putative Mg++ binding site [ion binding]; other site 36809009486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 36809009487 nucleotide binding region [chemical binding]; other site 36809009488 ATP-binding site [chemical binding]; other site 36809009489 DEAD/H associated; Region: DEAD_assoc; pfam08494 36809009490 Winged helix DNA-binding domain; Region: HTH_42; cl19833 36809009491 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 36809009492 dimer interface [polypeptide binding]; other site 36809009493 metal binding site [ion binding]; metal-binding site 36809009494 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 36809009495 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 36809009496 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 36809009497 active site 36809009498 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 36809009499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009500 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 36809009501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809009503 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809009504 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 36809009505 putative active site pocket [active] 36809009506 dimerization interface [polypeptide binding]; other site 36809009507 putative catalytic residue [active] 36809009508 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 36809009509 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 36809009510 metal binding site [ion binding]; metal-binding site 36809009511 putative dimer interface [polypeptide binding]; other site 36809009512 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 36809009513 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 36809009514 metal binding site [ion binding]; metal-binding site 36809009515 purine nucleoside phosphorylase; Provisional; Region: PRK08202 36809009516 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 36809009517 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 36809009518 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 36809009519 active site 36809009520 substrate binding site [chemical binding]; other site 36809009521 metal binding site [ion binding]; metal-binding site 36809009522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809009523 active site 36809009524 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 36809009525 NlpC/P60 family; Region: NLPC_P60; pfam00877 36809009526 DNA-directed RNA polymerase subunit B; Provisional; Region: PRK08565 36809009527 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 36809009528 adenosine deaminase; Provisional; Region: PRK09358 36809009529 active site 36809009530 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 36809009531 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 36809009532 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 36809009533 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 36809009534 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 36809009535 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 36809009536 active site 36809009537 catalytic motif [active] 36809009538 Zn binding site [ion binding]; other site 36809009539 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 36809009540 putative Iron-sulfur protein interface [polypeptide binding]; other site 36809009541 putative proximal heme binding site [chemical binding]; other site 36809009542 putative SdhD-like interface [polypeptide binding]; other site 36809009543 putative distal heme binding site [chemical binding]; other site 36809009544 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 36809009545 putative Iron-sulfur protein interface [polypeptide binding]; other site 36809009546 putative proximal heme binding site [chemical binding]; other site 36809009547 putative SdhC-like subunit interface [polypeptide binding]; other site 36809009548 putative distal heme binding site [chemical binding]; other site 36809009549 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 36809009550 L-aspartate oxidase; Provisional; Region: PRK06175 36809009551 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 36809009552 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 36809009553 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 36809009554 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 36809009555 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 36809009556 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809009557 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 36809009558 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809009559 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 36809009560 DNA binding residues [nucleotide binding] 36809009561 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809009562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 36809009563 binding surface 36809009564 Tetratricopeptide repeat; Region: TPR_19; pfam14559 36809009565 TPR motif; other site 36809009566 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 36809009567 Strictosidine synthase; Region: Str_synth; cl19733 36809009568 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 36809009569 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 36809009570 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 36809009571 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 36809009572 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 36809009573 active site 36809009574 HIGH motif; other site 36809009575 dimer interface [polypeptide binding]; other site 36809009576 KMSKS motif; other site 36809009577 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 36809009578 putative active site [active] 36809009579 putative catalytic site [active] 36809009580 putative DNA binding site [nucleotide binding]; other site 36809009581 putative phosphate binding site [ion binding]; other site 36809009582 metal binding site A [ion binding]; metal-binding site 36809009583 putative AP binding site [nucleotide binding]; other site 36809009584 putative metal binding site B [ion binding]; other site 36809009585 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009586 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809009587 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 36809009588 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 36809009589 homodimer interface [polypeptide binding]; other site 36809009590 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 36809009591 substrate-cofactor binding pocket; other site 36809009592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809009593 catalytic residue [active] 36809009594 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 36809009595 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 36809009596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809009597 S-adenosylmethionine binding site [chemical binding]; other site 36809009598 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 36809009599 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 36809009600 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 36809009601 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 36809009602 homodimer interface [polypeptide binding]; other site 36809009603 NADP binding site [chemical binding]; other site 36809009604 substrate binding site [chemical binding]; other site 36809009605 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 36809009606 FMN binding site [chemical binding]; other site 36809009607 dimer interface [polypeptide binding]; other site 36809009608 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 36809009609 active site 36809009610 FMN binding site [chemical binding]; other site 36809009611 substrate binding site [chemical binding]; other site 36809009612 putative catalytic residue [active] 36809009613 Predicted transcriptional regulators [Transcription]; Region: COG1733 36809009614 dimerization interface [polypeptide binding]; other site 36809009615 putative DNA binding site [nucleotide binding]; other site 36809009616 putative Zn2+ binding site [ion binding]; other site 36809009617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809009618 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809009619 NAD(P) binding site [chemical binding]; other site 36809009620 active site 36809009621 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 36809009622 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 36809009623 phosphopeptide binding site; other site 36809009624 Proline-rich; Region: Pro-rich; pfam15240 36809009625 YppG-like protein; Region: YppG; pfam14179 36809009626 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 36809009627 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 36809009628 phosphopeptide binding site; other site 36809009629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809009630 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 36809009631 Walker A/P-loop; other site 36809009632 ATP binding site [chemical binding]; other site 36809009633 Q-loop/lid; other site 36809009634 ABC transporter signature motif; other site 36809009635 Walker B; other site 36809009636 D-loop; other site 36809009637 H-loop/switch region; other site 36809009638 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 36809009639 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 36809009640 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 36809009641 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 36809009642 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 36809009643 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 36809009644 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 36809009645 Helix-turn-helix domain; Region: HTH_18; pfam12833 36809009646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809009647 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 36809009648 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 36809009649 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 36809009650 active site 36809009651 PHP Thumb interface [polypeptide binding]; other site 36809009652 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 36809009653 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 36809009654 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 36809009655 generic binding surface II; other site 36809009656 generic binding surface I; other site 36809009657 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009658 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 36809009659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809009660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809009661 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 36809009662 active site 36809009663 NTP binding site [chemical binding]; other site 36809009664 metal binding triad [ion binding]; metal-binding site 36809009665 antibiotic binding site [chemical binding]; other site 36809009666 Bacterial PH domain; Region: bPH_2; cl01348 36809009667 short chain dehydrogenase; Provisional; Region: PRK07201 36809009668 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 36809009669 putative NAD(P) binding site [chemical binding]; other site 36809009670 active site 36809009671 putative substrate binding site [chemical binding]; other site 36809009672 classical (c) SDRs; Region: SDR_c; cd05233 36809009673 NAD(P) binding site [chemical binding]; other site 36809009674 active site 36809009675 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 36809009676 active site 36809009677 DNA Polymerase Y-family; Region: PolY_like; cd03468 36809009678 active site 36809009679 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 36809009680 DNA binding site [nucleotide binding] 36809009681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809009682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809009683 active site 36809009684 phosphorylation site [posttranslational modification] 36809009685 intermolecular recognition site; other site 36809009686 dimerization interface [polypeptide binding]; other site 36809009687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809009688 DNA binding residues [nucleotide binding] 36809009689 dimerization interface [polypeptide binding]; other site 36809009690 PspC domain; Region: PspC; pfam04024 36809009691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 36809009692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809009693 ATP binding site [chemical binding]; other site 36809009694 Mg2+ binding site [ion binding]; other site 36809009695 G-X-G motif; other site 36809009696 PspC domain; Region: PspC; pfam04024 36809009697 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 36809009698 GMP synthase; Reviewed; Region: guaA; PRK00074 36809009699 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 36809009700 AMP/PPi binding site [chemical binding]; other site 36809009701 candidate oxyanion hole; other site 36809009702 catalytic triad [active] 36809009703 potential glutamine specificity residues [chemical binding]; other site 36809009704 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 36809009705 ATP Binding subdomain [chemical binding]; other site 36809009706 Ligand Binding sites [chemical binding]; other site 36809009707 Dimerization subdomain; other site 36809009708 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 36809009709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809009710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009711 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 36809009712 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 36809009713 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 36809009714 active site 36809009715 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 36809009716 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 36809009717 active site 36809009718 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 36809009719 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 36809009720 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 36809009721 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 36809009722 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809009723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809009724 DNA binding residues [nucleotide binding] 36809009725 Transcription factor WhiB; Region: Whib; pfam02467 36809009726 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 36809009727 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 36809009728 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 36809009729 ring oligomerisation interface [polypeptide binding]; other site 36809009730 ATP/Mg binding site [chemical binding]; other site 36809009731 stacking interactions; other site 36809009732 hinge regions; other site 36809009733 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 36809009734 oligomerisation interface [polypeptide binding]; other site 36809009735 mobile loop; other site 36809009736 roof hairpin; other site 36809009737 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 36809009738 UGMP family protein; Validated; Region: PRK09604 36809009739 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 36809009740 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 36809009741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809009742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809009743 Coenzyme A binding pocket [chemical binding]; other site 36809009744 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 36809009745 Glycoprotease family; Region: Peptidase_M22; pfam00814 36809009746 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 36809009747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809009748 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009749 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009750 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 36809009751 alanine racemase; Reviewed; Region: alr; PRK00053 36809009752 active site 36809009753 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 36809009754 dimer interface [polypeptide binding]; other site 36809009755 substrate binding site [chemical binding]; other site 36809009756 catalytic residues [active] 36809009757 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 36809009758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809009759 catalytic residue [active] 36809009760 Uncharacterized conserved protein [Function unknown]; Region: COG0062 36809009761 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 36809009762 putative substrate binding site [chemical binding]; other site 36809009763 putative ATP binding site [chemical binding]; other site 36809009764 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809009765 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009766 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 36809009767 catalytic site [active] 36809009768 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 36809009769 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 36809009770 glutaminase active site [active] 36809009771 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 36809009772 dimer interface [polypeptide binding]; other site 36809009773 active site 36809009774 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 36809009775 dimer interface [polypeptide binding]; other site 36809009776 active site 36809009777 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809009778 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 36809009779 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 36809009780 DNA packaging tegument protein UL25; Provisional; Region: PHA03249 36809009781 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 36809009782 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809009783 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809009784 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 36809009785 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 36809009786 putative active site [active] 36809009787 putative metal binding site [ion binding]; other site 36809009788 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 36809009789 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 36809009790 active site 36809009791 substrate binding site [chemical binding]; other site 36809009792 metal binding site [ion binding]; metal-binding site 36809009793 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 36809009794 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 36809009795 23S rRNA interface [nucleotide binding]; other site 36809009796 L3 interface [polypeptide binding]; other site 36809009797 Proteins of 100 residues with WXG; Region: WXG100; cl02005 36809009798 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 36809009799 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 36809009800 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 36809009801 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 36809009802 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 36809009803 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 36809009804 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 36809009805 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 36809009806 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 36809009807 Subtilase family; Region: Peptidase_S8; pfam00082 36809009808 active site 36809009809 catalytic residues [active] 36809009810 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 36809009811 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 36809009812 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 36809009813 CGNR zinc finger; Region: zf-CGNR; pfam11706 36809009814 EamA-like transporter family; Region: EamA; pfam00892 36809009815 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 36809009816 EamA-like transporter family; Region: EamA; pfam00892 36809009817 Cutinase; Region: Cutinase; pfam01083 36809009818 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809009819 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009820 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009821 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009822 Cutinase; Region: Cutinase; pfam01083 36809009823 Cutinase; Region: Cutinase; pfam01083 36809009824 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 36809009825 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 36809009826 dimerization interface 3.5A [polypeptide binding]; other site 36809009827 active site 36809009828 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 36809009829 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 36809009830 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 36809009831 alphaNTD homodimer interface [polypeptide binding]; other site 36809009832 alphaNTD - beta interaction site [polypeptide binding]; other site 36809009833 alphaNTD - beta' interaction site [polypeptide binding]; other site 36809009834 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 36809009835 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 36809009836 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 36809009837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 36809009838 RNA binding surface [nucleotide binding]; other site 36809009839 30S ribosomal protein S11; Validated; Region: PRK05309 36809009840 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 36809009841 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 36809009842 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 36809009843 rRNA binding site [nucleotide binding]; other site 36809009844 predicted 30S ribosome binding site; other site 36809009845 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 36809009846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 36809009848 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 36809009849 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 36809009850 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 36809009851 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 36809009852 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 36809009853 NAD binding site [chemical binding]; other site 36809009854 substrate binding site [chemical binding]; other site 36809009855 homodimer interface [polypeptide binding]; other site 36809009856 active site 36809009857 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 36809009858 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 36809009859 Septum formation; Region: Septum_form; pfam13845 36809009860 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 36809009861 active site 36809009862 adenylate kinase; Reviewed; Region: adk; PRK00279 36809009863 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 36809009864 AMP-binding site [chemical binding]; other site 36809009865 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 36809009866 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 36809009867 SecY translocase; Region: SecY; pfam00344 36809009868 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 36809009869 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 36809009870 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 36809009871 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 36809009872 tandem repeat interface [polypeptide binding]; other site 36809009873 oligomer interface [polypeptide binding]; other site 36809009874 active site residues [active] 36809009875 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 36809009876 tandem repeat interface [polypeptide binding]; other site 36809009877 oligomer interface [polypeptide binding]; other site 36809009878 active site residues [active] 36809009879 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809009880 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 36809009881 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 36809009882 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 36809009883 23S rRNA binding site [nucleotide binding]; other site 36809009884 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 36809009885 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 36809009886 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 36809009887 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 36809009888 5S rRNA interface [nucleotide binding]; other site 36809009889 L27 interface [polypeptide binding]; other site 36809009890 23S rRNA interface [nucleotide binding]; other site 36809009891 L5 interface [polypeptide binding]; other site 36809009892 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 36809009893 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 36809009894 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 36809009895 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 36809009896 glutamate dehydrogenase; Provisional; Region: PRK09414 36809009897 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 36809009898 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 36809009899 NAD(P) binding site [chemical binding]; other site 36809009900 Carboxylesterase family; Region: COesterase; pfam00135 36809009901 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 36809009902 substrate binding pocket [chemical binding]; other site 36809009903 catalytic triad [active] 36809009904 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 36809009905 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 36809009906 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 36809009907 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 36809009908 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 36809009909 RNA binding site [nucleotide binding]; other site 36809009910 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 36809009911 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 36809009912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809009913 putative substrate translocation pore; other site 36809009914 Cutinase; Region: Cutinase; pfam01083 36809009915 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809009916 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 36809009917 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 36809009918 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 36809009919 putative translocon interaction site; other site 36809009920 23S rRNA interface [nucleotide binding]; other site 36809009921 signal recognition particle (SRP54) interaction site; other site 36809009922 L23 interface [polypeptide binding]; other site 36809009923 trigger factor interaction site; other site 36809009924 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 36809009925 23S rRNA interface [nucleotide binding]; other site 36809009926 5S rRNA interface [nucleotide binding]; other site 36809009927 putative antibiotic binding site [chemical binding]; other site 36809009928 L25 interface [polypeptide binding]; other site 36809009929 L27 interface [polypeptide binding]; other site 36809009930 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 36809009931 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 36809009932 G-X-X-G motif; other site 36809009933 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 36809009934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009935 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 36809009936 putative translocon binding site; other site 36809009937 protein-rRNA interface [nucleotide binding]; other site 36809009938 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 36809009939 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 36809009940 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 36809009941 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 36809009942 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 36809009943 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 36809009944 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 36809009945 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 36809009946 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 36809009947 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 36809009948 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 36809009949 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809009950 CoenzymeA binding site [chemical binding]; other site 36809009951 subunit interaction site [polypeptide binding]; other site 36809009952 PHB binding site; other site 36809009953 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809009954 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 36809009955 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809009956 active site 36809009957 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 36809009958 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 36809009959 ethanolamine permease; Region: 2A0305; TIGR00908 36809009960 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809009961 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 36809009962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809009963 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 36809009964 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 36809009965 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 36809009966 active site 36809009967 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 36809009968 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 36809009969 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 36809009970 active site 36809009971 substrate binding site [chemical binding]; other site 36809009972 FMN binding site [chemical binding]; other site 36809009973 putative catalytic residues [active] 36809009974 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 36809009975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 36809009976 FeS/SAM binding site; other site 36809009977 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 36809009978 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 36809009979 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 36809009980 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809009981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 36809009982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809009983 Reductase C-terminal; Region: Reductase_C; pfam14759 36809009984 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809009985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809009986 putative DNA binding site [nucleotide binding]; other site 36809009987 putative Zn2+ binding site [ion binding]; other site 36809009988 AsnC family; Region: AsnC_trans_reg; pfam01037 36809009989 Amidinotransferase; Region: Amidinotransf; cl19186 36809009990 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809009991 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809009992 inhibitor-cofactor binding pocket; inhibition site 36809009993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809009994 catalytic residue [active] 36809009995 amino acid transporter; Region: 2A0306; TIGR00909 36809009996 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809009997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809009998 Ligand Binding Site [chemical binding]; other site 36809009999 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809010000 Ligand Binding Site [chemical binding]; other site 36809010001 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 36809010002 classical (c) SDRs; Region: SDR_c; cd05233 36809010003 NAD(P) binding site [chemical binding]; other site 36809010004 active site 36809010005 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 36809010006 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809010007 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 36809010008 elongation factor Tu; Reviewed; Region: PRK00049 36809010009 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 36809010010 G1 box; other site 36809010011 GEF interaction site [polypeptide binding]; other site 36809010012 GTP/Mg2+ binding site [chemical binding]; other site 36809010013 Switch I region; other site 36809010014 G2 box; other site 36809010015 G3 box; other site 36809010016 Switch II region; other site 36809010017 G4 box; other site 36809010018 G5 box; other site 36809010019 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 36809010020 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 36809010021 Antibiotic Binding Site [chemical binding]; other site 36809010022 elongation factor G; Reviewed; Region: PRK00007 36809010023 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 36809010024 G1 box; other site 36809010025 putative GEF interaction site [polypeptide binding]; other site 36809010026 GTP/Mg2+ binding site [chemical binding]; other site 36809010027 Switch I region; other site 36809010028 G2 box; other site 36809010029 G3 box; other site 36809010030 Switch II region; other site 36809010031 G4 box; other site 36809010032 G5 box; other site 36809010033 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 36809010034 Elongation Factor G, domain II; Region: EFG_II; pfam14492 36809010035 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 36809010036 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 36809010037 30S ribosomal protein S7; Validated; Region: PRK05302 36809010038 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 36809010039 S17 interaction site [polypeptide binding]; other site 36809010040 S8 interaction site; other site 36809010041 16S rRNA interaction site [nucleotide binding]; other site 36809010042 streptomycin interaction site [chemical binding]; other site 36809010043 23S rRNA interaction site [nucleotide binding]; other site 36809010044 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 36809010045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010046 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809010047 WHG domain; Region: WHG; pfam13305 36809010048 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 36809010049 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 36809010050 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809010051 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809010052 enoyl-CoA hydratase; Provisional; Region: PRK08259 36809010053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809010054 substrate binding site [chemical binding]; other site 36809010055 oxyanion hole (OAH) forming residues; other site 36809010056 trimer interface [polypeptide binding]; other site 36809010057 PaaX-like protein; Region: PaaX; pfam07848 36809010058 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 36809010059 enoyl-CoA hydratase; Provisional; Region: PRK08272 36809010060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809010061 substrate binding site [chemical binding]; other site 36809010062 oxyanion hole (OAH) forming residues; other site 36809010063 trimer interface [polypeptide binding]; other site 36809010064 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 36809010065 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809010066 active site 36809010067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809010068 dimerization interface [polypeptide binding]; other site 36809010069 putative DNA binding site [nucleotide binding]; other site 36809010070 putative Zn2+ binding site [ion binding]; other site 36809010071 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 36809010072 putative hydrophobic ligand binding site [chemical binding]; other site 36809010073 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 36809010074 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 36809010075 Spore germination protein; Region: Spore_permease; cl17796 36809010076 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 36809010077 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 36809010078 beta and beta' interface [polypeptide binding]; other site 36809010079 beta' and sigma factor interface [polypeptide binding]; other site 36809010080 Zn-binding [ion binding]; other site 36809010081 active site region [active] 36809010082 catalytic site [active] 36809010083 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 36809010084 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 36809010085 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 36809010086 G-loop; other site 36809010087 DNA binding site [nucleotide binding] 36809010088 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 36809010089 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 36809010090 RPB12 interaction site [polypeptide binding]; other site 36809010091 RPB1 interaction site [polypeptide binding]; other site 36809010092 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 36809010093 RPB10 interaction site [polypeptide binding]; other site 36809010094 RPB11 interaction site [polypeptide binding]; other site 36809010095 RPB3 interaction site [polypeptide binding]; other site 36809010096 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 36809010097 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 36809010098 molybdopterin cofactor binding site; other site 36809010099 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 36809010100 molybdopterin cofactor binding site; other site 36809010101 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 36809010102 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 36809010103 Walker A/P-loop; other site 36809010104 ATP binding site [chemical binding]; other site 36809010105 Q-loop/lid; other site 36809010106 ABC transporter signature motif; other site 36809010107 Walker B; other site 36809010108 D-loop; other site 36809010109 H-loop/switch region; other site 36809010110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809010111 putative substrate translocation pore; other site 36809010112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809010113 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 36809010114 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 36809010115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010117 WHG domain; Region: WHG; pfam13305 36809010118 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 36809010119 core dimer interface [polypeptide binding]; other site 36809010120 peripheral dimer interface [polypeptide binding]; other site 36809010121 L10 interface [polypeptide binding]; other site 36809010122 L11 interface [polypeptide binding]; other site 36809010123 putative EF-Tu interaction site [polypeptide binding]; other site 36809010124 putative EF-G interaction site [polypeptide binding]; other site 36809010125 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 36809010126 23S rRNA interface [nucleotide binding]; other site 36809010127 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 36809010128 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809010129 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809010130 TAP-like protein; Region: Abhydrolase_4; pfam08386 36809010131 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 36809010132 active site 36809010133 ATP binding site [chemical binding]; other site 36809010134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809010135 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 36809010136 TAP-like protein; Region: Abhydrolase_4; pfam08386 36809010137 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 36809010138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 36809010139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809010140 S-adenosylmethionine binding site [chemical binding]; other site 36809010141 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 36809010142 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 36809010143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809010144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010146 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 36809010147 FAD binding domain; Region: FAD_binding_4; pfam01565 36809010148 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 36809010149 diacylglycerol kinase; Reviewed; Region: PRK11914 36809010150 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 36809010151 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 36809010152 YCII-related domain; Region: YCII; cl00999 36809010153 YCII-related domain; Region: YCII; cl00999 36809010154 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 36809010155 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 36809010156 DNA binding residues [nucleotide binding] 36809010157 MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar...; Region: MIT; cl00299 36809010158 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809010159 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809010160 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 36809010161 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 36809010162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 36809010163 Histidine kinase; Region: HisKA_3; pfam07730 36809010164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809010165 ATP binding site [chemical binding]; other site 36809010166 Mg2+ binding site [ion binding]; other site 36809010167 G-X-G motif; other site 36809010168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809010169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809010170 active site 36809010171 phosphorylation site [posttranslational modification] 36809010172 intermolecular recognition site; other site 36809010173 dimerization interface [polypeptide binding]; other site 36809010174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809010175 DNA binding residues [nucleotide binding] 36809010176 dimerization interface [polypeptide binding]; other site 36809010177 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 36809010178 mRNA/rRNA interface [nucleotide binding]; other site 36809010179 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 36809010180 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 36809010181 23S rRNA interface [nucleotide binding]; other site 36809010182 L7/L12 interface [polypeptide binding]; other site 36809010183 putative thiostrepton binding site; other site 36809010184 L25 interface [polypeptide binding]; other site 36809010185 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 36809010186 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 36809010187 putative homodimer interface [polypeptide binding]; other site 36809010188 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 36809010189 heterodimer interface [polypeptide binding]; other site 36809010190 homodimer interface [polypeptide binding]; other site 36809010191 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 36809010192 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809010193 (3R)-hydroxyacyl-ACP dehydratase subunit HadB; Provisional; Region: PRK13693 36809010194 active site 2 [active] 36809010195 active site 1 [active] 36809010196 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809010197 active site 36809010198 catalytic site [active] 36809010199 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 36809010200 Ferritin-like domain; Region: Ferritin; pfam00210 36809010201 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 36809010202 dimerization interface [polypeptide binding]; other site 36809010203 DPS ferroxidase diiron center [ion binding]; other site 36809010204 ion pore; other site 36809010205 intracellular protease, PfpI family; Region: PfpI; TIGR01382 36809010206 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 36809010207 proposed catalytic triad [active] 36809010208 conserved cys residue [active] 36809010209 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 36809010210 Predicted kinase [General function prediction only]; Region: COG0645 36809010211 AAA domain; Region: AAA_33; pfam13671 36809010212 Nitroreductase family; Region: Nitroreductase; pfam00881 36809010213 dimer interface [polypeptide binding]; other site 36809010214 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809010215 Ligand Binding Site [chemical binding]; other site 36809010216 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809010217 Ligand Binding Site [chemical binding]; other site 36809010218 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 36809010219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809010220 Walker A motif; other site 36809010221 ATP binding site [chemical binding]; other site 36809010222 Walker B motif; other site 36809010223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809010224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809010225 DNA binding residues [nucleotide binding] 36809010226 dimerization interface [polypeptide binding]; other site 36809010227 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 36809010228 putative heme binding pocket [chemical binding]; other site 36809010229 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 36809010230 Animal haem peroxidase; Region: An_peroxidase; pfam03098 36809010231 putative heme binding site [chemical binding]; other site 36809010232 putative active site [active] 36809010233 putative substrate binding site [chemical binding]; other site 36809010234 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 36809010235 Subtilase family; Region: Peptidase_S8; pfam00082 36809010236 active site 36809010237 catalytic triad [active] 36809010238 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809010239 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 36809010240 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 36809010241 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809010242 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 36809010243 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 36809010244 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 36809010245 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 36809010246 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 36809010247 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 36809010248 FAD binding pocket [chemical binding]; other site 36809010249 FAD binding motif [chemical binding]; other site 36809010250 phosphate binding motif [ion binding]; other site 36809010251 beta-alpha-beta structure motif; other site 36809010252 NAD(p) ribose binding residues [chemical binding]; other site 36809010253 NAD binding pocket [chemical binding]; other site 36809010254 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 36809010255 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809010256 catalytic loop [active] 36809010257 iron binding site [ion binding]; other site 36809010258 short chain dehydrogenase; Provisional; Region: PRK06181 36809010259 classical (c) SDRs; Region: SDR_c; cd05233 36809010260 NAD(P) binding site [chemical binding]; other site 36809010261 active site 36809010262 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809010264 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 36809010265 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 36809010266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010268 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809010269 CoenzymeA binding site [chemical binding]; other site 36809010270 subunit interaction site [polypeptide binding]; other site 36809010271 PHB binding site; other site 36809010272 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809010273 TIGR03086 family protein; Region: TIGR03086 36809010274 heat shock protein HtpX; Provisional; Region: PRK03072 36809010275 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 36809010276 substrate binding pocket [chemical binding]; other site 36809010277 chain length determination region; other site 36809010278 substrate-Mg2+ binding site; other site 36809010279 catalytic residues [active] 36809010280 aspartate-rich region 1; other site 36809010281 active site lid residues [active] 36809010282 aspartate-rich region 2; other site 36809010283 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 36809010284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809010285 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 36809010286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809010287 S-adenosylmethionine binding site [chemical binding]; other site 36809010288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809010289 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 36809010290 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 36809010291 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 36809010292 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 36809010293 dimer interface [polypeptide binding]; other site 36809010294 tetramer interface [polypeptide binding]; other site 36809010295 PYR/PP interface [polypeptide binding]; other site 36809010296 TPP binding site [chemical binding]; other site 36809010297 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 36809010298 TPP-binding site; other site 36809010299 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809010300 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809010301 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 36809010302 O-succinylbenzoate synthase; Provisional; Region: PRK02901 36809010303 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 36809010304 active site 36809010305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809010306 catalytic core [active] 36809010307 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 36809010308 Clp amino terminal domain; Region: Clp_N; pfam02861 36809010309 Clp amino terminal domain; Region: Clp_N; pfam02861 36809010310 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809010311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 36809010312 metal binding site [ion binding]; metal-binding site 36809010313 active site 36809010314 I-site; other site 36809010315 Pirin-related protein [General function prediction only]; Region: COG1741 36809010316 Pirin; Region: Pirin; pfam02678 36809010317 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 36809010318 GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542 36809010319 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809010320 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809010321 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 36809010322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809010323 substrate binding site [chemical binding]; other site 36809010324 oxyanion hole (OAH) forming residues; other site 36809010325 trimer interface [polypeptide binding]; other site 36809010326 short chain dehydrogenase; Provisional; Region: PRK08278 36809010327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809010328 NAD(P) binding site [chemical binding]; other site 36809010329 active site 36809010330 short chain dehydrogenase; Provisional; Region: PRK05866 36809010331 classical (c) SDRs; Region: SDR_c; cd05233 36809010332 NAD(P) binding site [chemical binding]; other site 36809010333 active site 36809010334 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809010335 active site 36809010336 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 36809010337 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 36809010338 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 36809010339 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809010340 acyl-activating enzyme (AAE) consensus motif; other site 36809010341 AMP binding site [chemical binding]; other site 36809010342 active site 36809010343 CoA binding site [chemical binding]; other site 36809010344 Cupin domain; Region: Cupin_2; pfam07883 36809010345 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 36809010346 hydrophobic ligand binding site; other site 36809010347 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809010348 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 36809010349 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 36809010350 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 36809010351 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 36809010352 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 36809010353 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 36809010354 putative active site [active] 36809010355 Clp amino terminal domain; Region: Clp_N; pfam02861 36809010356 Clp amino terminal domain; Region: Clp_N; pfam02861 36809010357 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 36809010358 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893 36809010359 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809010360 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809010361 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809010362 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 36809010363 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 36809010364 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 36809010365 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809010366 catalytic residue [active] 36809010367 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 36809010368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809010369 NAD(P) binding site [chemical binding]; other site 36809010370 active site 36809010371 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809010373 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 36809010374 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 36809010375 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 36809010376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 36809010377 P-loop; other site 36809010378 Magnesium ion binding site [ion binding]; other site 36809010379 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 36809010380 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 36809010381 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 36809010382 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 36809010383 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 36809010384 catalytic residues [active] 36809010385 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809010386 catalytic core [active] 36809010387 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 36809010388 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809010389 inhibitor-cofactor binding pocket; inhibition site 36809010390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809010391 catalytic residue [active] 36809010392 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809010393 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809010394 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 36809010395 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 36809010396 active site 36809010397 Zn binding site [ion binding]; other site 36809010398 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 36809010399 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 36809010400 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 36809010401 metal-binding site [ion binding] 36809010402 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 36809010403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809010404 motif II; other site 36809010405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809010406 S-adenosylmethionine binding site [chemical binding]; other site 36809010407 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 36809010408 dimer interface [polypeptide binding]; other site 36809010409 active site 36809010410 Schiff base residues; other site 36809010411 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 36809010412 active site 36809010413 homodimer interface [polypeptide binding]; other site 36809010414 SAM binding site [chemical binding]; other site 36809010415 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 36809010416 active site 36809010417 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 36809010418 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 36809010419 domain interfaces; other site 36809010420 active site 36809010421 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 36809010422 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 36809010423 tRNA; other site 36809010424 putative tRNA binding site [nucleotide binding]; other site 36809010425 putative NADP binding site [chemical binding]; other site 36809010426 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 36809010427 Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659 36809010428 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 36809010429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 36809010430 motif II; other site 36809010431 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809010432 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 36809010433 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 36809010434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809010435 Uncharacterized conserved protein [Function unknown]; Region: COG5361 36809010436 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 36809010437 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 36809010438 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 36809010439 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 36809010440 FMN binding site [chemical binding]; other site 36809010441 substrate binding site [chemical binding]; other site 36809010442 putative catalytic residue [active] 36809010443 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 36809010444 putative acyl-acceptor binding pocket; other site 36809010445 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 36809010446 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809010447 putative NAD(P) binding site [chemical binding]; other site 36809010448 active site 36809010449 putative substrate binding site [chemical binding]; other site 36809010450 DNA binding domain, excisionase family; Region: excise; TIGR01764 36809010451 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 36809010452 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 36809010453 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 36809010454 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809010455 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 36809010456 active site 36809010457 diiron metal binding site [ion binding]; other site 36809010458 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809010459 Domain of unknown function (DUF385); Region: DUF385; pfam04075 36809010460 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 36809010461 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809010462 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 36809010463 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 36809010464 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 36809010465 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 36809010466 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 36809010467 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 36809010468 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 36809010469 putative hydrophobic ligand binding site [chemical binding]; other site 36809010470 protein interface [polypeptide binding]; other site 36809010471 gate; other site 36809010472 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809010474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809010475 S-adenosylmethionine binding site [chemical binding]; other site 36809010476 short chain dehydrogenase; Validated; Region: PRK05855 36809010477 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809010478 classical (c) SDRs; Region: SDR_c; cd05233 36809010479 NAD(P) binding site [chemical binding]; other site 36809010480 active site 36809010481 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 36809010482 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 36809010483 FMN-binding pocket [chemical binding]; other site 36809010484 flavin binding motif; other site 36809010485 phosphate binding motif [ion binding]; other site 36809010486 beta-alpha-beta structure motif; other site 36809010487 NAD binding pocket [chemical binding]; other site 36809010488 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809010489 catalytic loop [active] 36809010490 iron binding site [ion binding]; other site 36809010491 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 36809010492 short chain dehydrogenase; Provisional; Region: PRK07825 36809010493 classical (c) SDRs; Region: SDR_c; cd05233 36809010494 NAD(P) binding site [chemical binding]; other site 36809010495 active site 36809010496 short chain dehydrogenase; Provisional; Region: PRK07825 36809010497 classical (c) SDRs; Region: SDR_c; cd05233 36809010498 NAD(P) binding site [chemical binding]; other site 36809010499 active site 36809010500 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010501 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809010502 Predicted metal-dependent hydrolase; Region: Metal_hydrol; cl19844 36809010503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010507 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 36809010508 Permease; Region: Permease; pfam02405 36809010509 Permease; Region: Permease; pfam02405 36809010510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010511 mce related protein; Region: MCE; pfam02470 36809010512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010513 mce related protein; Region: MCE; pfam02470 36809010514 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010515 mce related protein; Region: MCE; pfam02470 36809010516 mce related protein; Region: MCE; pfam02470 36809010517 Heterokaryon incompatibility protein Het-C; Region: Het-C; pfam07217 36809010518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010519 mce related protein; Region: MCE; pfam02470 36809010520 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010521 mce related protein; Region: MCE; pfam02470 36809010522 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 36809010523 putative hydrophobic ligand binding site [chemical binding]; other site 36809010524 protein interface [polypeptide binding]; other site 36809010525 gate; other site 36809010526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809010527 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010528 hydrophobic ligand binding site; other site 36809010529 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 36809010530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809010531 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010532 short chain dehydrogenase; Provisional; Region: PRK07825 36809010533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809010534 NAD(P) binding site [chemical binding]; other site 36809010535 active site 36809010536 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809010537 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809010538 ABC1 family; Region: ABC1; cl17513 36809010539 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 36809010540 active site 36809010541 ATP binding site [chemical binding]; other site 36809010542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809010547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809010548 active site 36809010549 phosphorylation site [posttranslational modification] 36809010550 intermolecular recognition site; other site 36809010551 dimerization interface [polypeptide binding]; other site 36809010552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809010553 DNA binding site [nucleotide binding] 36809010554 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 36809010555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 36809010556 dimer interface [polypeptide binding]; other site 36809010557 phosphorylation site [posttranslational modification] 36809010558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809010559 ATP binding site [chemical binding]; other site 36809010560 Mg2+ binding site [ion binding]; other site 36809010561 G-X-G motif; other site 36809010562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 36809010563 catalytic core [active] 36809010564 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809010566 dinuclear metal binding motif [ion binding]; other site 36809010567 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 36809010568 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809010569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809010570 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809010571 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 36809010572 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809010573 classical (c) SDRs; Region: SDR_c; cd05233 36809010574 NAD(P) binding site [chemical binding]; other site 36809010575 active site 36809010576 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 36809010577 4-coumarate--CoA ligase; Region: PLN02246 36809010578 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809010579 acyl-activating enzyme (AAE) consensus motif; other site 36809010580 AMP binding site [chemical binding]; other site 36809010581 active site 36809010582 CoA binding site [chemical binding]; other site 36809010583 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 36809010584 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 36809010585 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 36809010586 putative ADP-binding pocket [chemical binding]; other site 36809010587 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 36809010588 hydrophobic ligand binding site; other site 36809010589 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 36809010590 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 36809010591 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 36809010592 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 36809010593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809010594 NAD(P) binding site [chemical binding]; other site 36809010595 active site 36809010596 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 36809010597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 36809010598 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 36809010599 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 36809010600 Predicted transcriptional regulators [Transcription]; Region: COG1733 36809010601 dimerization interface [polypeptide binding]; other site 36809010602 putative DNA binding site [nucleotide binding]; other site 36809010603 putative Zn2+ binding site [ion binding]; other site 36809010604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809010605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809010606 putative substrate translocation pore; other site 36809010607 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 36809010608 FAD binding domain; Region: FAD_binding_4; cl19922 36809010609 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 36809010610 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 36809010611 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 36809010612 CHAT domain; Region: CHAT; cl19248 36809010613 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 36809010614 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 36809010615 putative active site [active] 36809010616 catalytic triad [active] 36809010617 putative dimer interface [polypeptide binding]; other site 36809010618 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 36809010619 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 36809010620 intersubunit interface [polypeptide binding]; other site 36809010621 active site 36809010622 catalytic residue [active] 36809010623 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 36809010624 tetramer interface [polypeptide binding]; other site 36809010625 active site 36809010626 Mg2+/Mn2+ binding site [ion binding]; other site 36809010627 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 36809010628 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 36809010629 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 36809010630 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809010631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809010632 non-specific DNA binding site [nucleotide binding]; other site 36809010633 salt bridge; other site 36809010634 sequence-specific DNA binding site [nucleotide binding]; other site 36809010635 Predicted membrane protein [Function unknown]; Region: COG2733 36809010636 Protein of unknown function (DUF445); Region: DUF445; pfam04286 36809010637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010639 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 36809010640 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 36809010641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809010642 S-adenosylmethionine binding site [chemical binding]; other site 36809010643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010645 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 36809010646 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809010647 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 36809010648 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 36809010649 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 36809010650 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 36809010651 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 36809010652 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 36809010653 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 36809010654 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 36809010655 tetramer interface [polypeptide binding]; other site 36809010656 active site 36809010657 Mg2+/Mn2+ binding site [ion binding]; other site 36809010658 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 36809010659 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809010660 active site 2 [active] 36809010661 active site 1 [active] 36809010662 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 36809010663 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 36809010664 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809010665 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 36809010666 acyl-activating enzyme (AAE) consensus motif; other site 36809010667 AMP binding site [chemical binding]; other site 36809010668 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809010669 Condensation domain; Region: Condensation; cl19241 36809010670 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809010671 Condensation domain; Region: Condensation; pfam00668 36809010672 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809010673 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809010674 acyl-activating enzyme (AAE) consensus motif; other site 36809010675 AMP binding site [chemical binding]; other site 36809010676 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809010677 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 36809010678 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 36809010679 putative NAD(P) binding site [chemical binding]; other site 36809010680 active site 36809010681 putative substrate binding site [chemical binding]; other site 36809010682 Condensation domain; Region: Condensation; cl19241 36809010683 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809010684 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 36809010685 acyl-activating enzyme (AAE) consensus motif; other site 36809010686 AMP binding site [chemical binding]; other site 36809010687 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809010688 Condensation domain; Region: Condensation; cl19241 36809010689 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809010690 Condensation domain; Region: Condensation; pfam00668 36809010691 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809010692 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809010693 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809010694 acyl-activating enzyme (AAE) consensus motif; other site 36809010695 AMP binding site [chemical binding]; other site 36809010696 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809010697 Condensation domain; Region: Condensation; cl19241 36809010698 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809010699 Condensation domain; Region: Condensation; pfam00668 36809010700 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809010701 MbtH-like protein; Region: MbtH; pfam03621 36809010702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809010703 S-adenosylmethionine binding site [chemical binding]; other site 36809010704 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 36809010705 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 36809010706 homodimer interface [polypeptide binding]; other site 36809010707 active site 36809010708 TDP-binding site; other site 36809010709 acceptor substrate-binding pocket; other site 36809010710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 36809010711 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809010712 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 36809010713 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 36809010714 homodimer interface [polypeptide binding]; other site 36809010715 active site 36809010716 TDP-binding site; other site 36809010717 acceptor substrate-binding pocket; other site 36809010718 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 36809010719 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809010720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809010721 S-adenosylmethionine binding site [chemical binding]; other site 36809010722 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809010723 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809010724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809010725 NAD(P) binding site [chemical binding]; other site 36809010726 active site 36809010727 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 36809010728 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 36809010729 homodimer interface [polypeptide binding]; other site 36809010730 active site 36809010731 TDP-binding site; other site 36809010732 acceptor substrate-binding pocket; other site 36809010733 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 36809010734 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 36809010735 substrate binding site; other site 36809010736 tetramer interface; other site 36809010737 Transport protein; Region: actII; TIGR00833 36809010738 MMPL family; Region: MMPL; pfam03176 36809010739 MMPL family; Region: MMPL; pfam03176 36809010740 Transport protein; Region: actII; TIGR00833 36809010741 MMPL family; Region: MMPL; pfam03176 36809010742 MMPL family; Region: MMPL; pfam03176 36809010743 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809010744 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809010745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809010746 non-specific DNA binding site [nucleotide binding]; other site 36809010747 salt bridge; other site 36809010748 sequence-specific DNA binding site [nucleotide binding]; other site 36809010749 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 36809010750 Domain of unknown function (DUF955); Region: DUF955; pfam06114 36809010751 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 36809010752 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809010753 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809010754 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 36809010755 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 36809010756 active site 36809010757 catalytic tetrad [active] 36809010758 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809010759 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 36809010760 DNA binding residues [nucleotide binding] 36809010761 putative dimer interface [polypeptide binding]; other site 36809010762 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 36809010763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809010764 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 36809010765 active site 36809010766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 36809010767 Sterol carrier protein domain; Region: SCP2_2; pfam13530 36809010768 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 36809010769 active site 36809010770 non-prolyl cis peptide bond; other site 36809010771 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 36809010772 active site clefts [active] 36809010773 zinc binding site [ion binding]; other site 36809010774 dimer interface [polypeptide binding]; other site 36809010775 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 36809010776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809010777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809010778 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809010779 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 36809010780 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 36809010781 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809010782 Secretory lipase; Region: LIP; pfam03583 36809010783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809010784 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 36809010785 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 36809010786 NAD(P) binding site [chemical binding]; other site 36809010787 catalytic residues [active] 36809010788 Protein of unknown function (DUF664); Region: DUF664; pfam04978 36809010789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809010790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809010791 putative substrate translocation pore; other site 36809010792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809010793 dimerization interface [polypeptide binding]; other site 36809010794 putative DNA binding site [nucleotide binding]; other site 36809010795 putative Zn2+ binding site [ion binding]; other site 36809010796 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 36809010797 putative hydrophobic ligand binding site [chemical binding]; other site 36809010798 PE-PPE domain; Region: PE-PPE; pfam08237 36809010799 YHYH protein; Region: YHYH; pfam14240 36809010800 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 36809010801 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 36809010802 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 36809010803 active site 36809010804 homotetramer interface [polypeptide binding]; other site 36809010805 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010806 mce related protein; Region: MCE; pfam02470 36809010807 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010808 mce related protein; Region: MCE; pfam02470 36809010809 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010810 mce related protein; Region: MCE; pfam02470 36809010811 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010812 mce related protein; Region: MCE; pfam02470 36809010813 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 36809010814 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809010815 mce related protein; Region: MCE; pfam02470 36809010816 Laminin Domain II; Region: Laminin_II; pfam06009 36809010817 mce related protein; Region: MCE; pfam02470 36809010818 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 36809010819 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 36809010820 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 36809010821 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 36809010822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809010823 NAD(P) binding site [chemical binding]; other site 36809010824 active site 36809010825 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 36809010826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809010827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809010828 active site 36809010829 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809010830 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 36809010831 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 36809010832 active site 36809010833 acyl-CoA synthetase; Validated; Region: PRK07867 36809010834 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809010835 acyl-activating enzyme (AAE) consensus motif; other site 36809010836 AMP binding site [chemical binding]; other site 36809010837 active site 36809010838 CoA binding site [chemical binding]; other site 36809010839 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 36809010840 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 36809010841 putative active site [active] 36809010842 Nitronate monooxygenase; Region: NMO; pfam03060 36809010843 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 36809010844 FMN binding site [chemical binding]; other site 36809010845 substrate binding site [chemical binding]; other site 36809010846 putative catalytic residue [active] 36809010847 acyl-CoA synthetase; Validated; Region: PRK07798 36809010848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809010849 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 36809010850 acyl-activating enzyme (AAE) consensus motif; other site 36809010851 acyl-activating enzyme (AAE) consensus motif; other site 36809010852 putative AMP binding site [chemical binding]; other site 36809010853 putative active site [active] 36809010854 putative CoA binding site [chemical binding]; other site 36809010855 enoyl-CoA hydratase; Provisional; Region: PRK07799 36809010856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809010857 substrate binding site [chemical binding]; other site 36809010858 oxyanion hole (OAH) forming residues; other site 36809010859 trimer interface [polypeptide binding]; other site 36809010860 ATP-dependent protease La (LON) domain; Region: LON; cl19481 36809010861 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809010862 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 36809010863 DUF35 OB-fold domain; Region: DUF35; pfam01796 36809010864 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 36809010865 DUF35 OB-fold domain; Region: DUF35; pfam01796 36809010866 lipid-transfer protein; Provisional; Region: PRK07937 36809010867 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 36809010868 active site 36809010869 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 36809010870 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 36809010871 active site 36809010872 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 36809010873 ferredoxin-NADP+ reductase; Region: PLN02852 36809010874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809010875 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 36809010876 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 36809010877 trimer interface [polypeptide binding]; other site 36809010878 putative metal binding site [ion binding]; other site 36809010879 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 36809010880 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 36809010881 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 36809010882 putative active site [active] 36809010883 dimerization interface [polypeptide binding]; other site 36809010884 putative tRNAtyr binding site [nucleotide binding]; other site 36809010885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 36809010886 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 36809010887 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 36809010888 short chain dehydrogenase; Provisional; Region: PRK07890 36809010889 classical (c) SDRs; Region: SDR_c; cd05233 36809010890 NAD(P) binding site [chemical binding]; other site 36809010891 active site 36809010892 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809010893 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 36809010894 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 36809010895 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 36809010896 Active Sites [active] 36809010897 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 36809010898 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 36809010899 CysD dimerization site [polypeptide binding]; other site 36809010900 G1 box; other site 36809010901 putative GEF interaction site [polypeptide binding]; other site 36809010902 GTP/Mg2+ binding site [chemical binding]; other site 36809010903 Switch I region; other site 36809010904 G2 box; other site 36809010905 G3 box; other site 36809010906 Switch II region; other site 36809010907 G4 box; other site 36809010908 G5 box; other site 36809010909 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 36809010910 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 36809010911 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 36809010912 ligand-binding site [chemical binding]; other site 36809010913 carboxylate-amine ligase; Provisional; Region: PRK13517 36809010914 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 36809010915 E-class dimer interface [polypeptide binding]; other site 36809010916 P-class dimer interface [polypeptide binding]; other site 36809010917 active site 36809010918 Cu2+ binding site [ion binding]; other site 36809010919 Zn2+ binding site [ion binding]; other site 36809010920 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 36809010921 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 36809010922 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 36809010923 active site 36809010924 catalytic residues [active] 36809010925 metal binding site [ion binding]; metal-binding site 36809010926 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 36809010927 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 36809010928 putative catalytic site [active] 36809010929 putative phosphate binding site [ion binding]; other site 36809010930 active site 36809010931 metal binding site A [ion binding]; metal-binding site 36809010932 DNA binding site [nucleotide binding] 36809010933 putative AP binding site [nucleotide binding]; other site 36809010934 putative metal binding site B [ion binding]; other site 36809010935 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 36809010936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809010937 putative substrate translocation pore; other site 36809010938 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 36809010939 ThiC-associated domain; Region: ThiC-associated; pfam13667 36809010940 ThiC family; Region: ThiC; pfam01964 36809010941 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 36809010942 dimer interface [polypeptide binding]; other site 36809010943 substrate binding site [chemical binding]; other site 36809010944 ATP binding site [chemical binding]; other site 36809010945 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809010946 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 36809010947 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 36809010948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809010949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809010950 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 36809010951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809010952 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 36809010953 DNA binding residues [nucleotide binding] 36809010954 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809010955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809010956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809010957 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 36809010958 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 36809010959 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809010960 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 36809010961 tetrameric interface [polypeptide binding]; other site 36809010962 NAD binding site [chemical binding]; other site 36809010963 catalytic residues [active] 36809010964 substrate binding site [chemical binding]; other site 36809010965 tyramine oxidase; Provisional; Region: tynA; PRK11504 36809010966 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 36809010967 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 36809010968 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 36809010969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 36809010970 Ligand Binding Site [chemical binding]; other site 36809010971 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 36809010972 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 36809010973 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809010974 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809010975 inhibitor-cofactor binding pocket; inhibition site 36809010976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809010977 catalytic residue [active] 36809010978 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 36809010979 tetramerization interface [polypeptide binding]; other site 36809010980 NAD(P) binding site [chemical binding]; other site 36809010981 catalytic residues [active] 36809010982 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 36809010983 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 36809010984 active site 36809010985 iron coordination sites [ion binding]; other site 36809010986 substrate binding pocket [chemical binding]; other site 36809010987 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 36809010988 putative active site [active] 36809010989 putative CoA binding site [chemical binding]; other site 36809010990 nudix motif; other site 36809010991 metal binding site [ion binding]; metal-binding site 36809010992 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 36809010993 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 36809010994 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 36809010995 PA/protease or protease-like domain interface [polypeptide binding]; other site 36809010996 active site 36809010997 metal binding site [ion binding]; metal-binding site 36809010998 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 36809010999 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 36809011000 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 36809011001 PA/protease or protease-like domain interface [polypeptide binding]; other site 36809011002 active site 36809011003 metal binding site [ion binding]; metal-binding site 36809011004 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 36809011005 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 36809011006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 36809011007 Walker A/P-loop; other site 36809011008 ATP binding site [chemical binding]; other site 36809011009 Q-loop/lid; other site 36809011010 ABC transporter signature motif; other site 36809011011 Walker B; other site 36809011012 D-loop; other site 36809011013 H-loop/switch region; other site 36809011014 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 36809011015 ThiS interaction site; other site 36809011016 putative active site [active] 36809011017 tetramer interface [polypeptide binding]; other site 36809011018 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 36809011019 thiS-thiF/thiG interaction site; other site 36809011020 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 36809011021 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 36809011022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809011023 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 36809011024 thiamine phosphate binding site [chemical binding]; other site 36809011025 active site 36809011026 pyrophosphate binding site [ion binding]; other site 36809011027 PAS fold; Region: PAS_3; pfam08447 36809011028 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 36809011029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 36809011030 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 36809011031 substrate binding pocket [chemical binding]; other site 36809011032 membrane-bound complex binding site; other site 36809011033 hinge residues; other site 36809011034 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 36809011035 Catalytic domain of Protein Kinases; Region: PKc; cd00180 36809011036 active site 36809011037 ATP binding site [chemical binding]; other site 36809011038 substrate binding site [chemical binding]; other site 36809011039 activation loop (A-loop); other site 36809011040 Tetratricopeptide repeat; Region: TPR_16; pfam13432 36809011041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 36809011042 binding surface 36809011043 TPR motif; other site 36809011044 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 36809011045 phosphate acetyltransferase; Reviewed; Region: PRK05632 36809011046 DRTGG domain; Region: DRTGG; pfam07085 36809011047 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 36809011048 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 36809011049 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 36809011050 active site 36809011051 catalytic site [active] 36809011052 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 36809011053 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 36809011054 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809011055 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 36809011056 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 36809011057 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809011058 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 36809011059 active site 36809011060 non-prolyl cis peptide bond; other site 36809011061 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809011062 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809011063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809011064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 36809011065 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 36809011066 substrate binding pocket [chemical binding]; other site 36809011067 membrane-bound complex binding site; other site 36809011068 hinge residues; other site 36809011069 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 36809011070 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 36809011071 Walker A/P-loop; other site 36809011072 ATP binding site [chemical binding]; other site 36809011073 Q-loop/lid; other site 36809011074 ABC transporter signature motif; other site 36809011075 Walker B; other site 36809011076 D-loop; other site 36809011077 H-loop/switch region; other site 36809011078 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 36809011079 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 36809011080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809011081 dimer interface [polypeptide binding]; other site 36809011082 conserved gate region; other site 36809011083 putative PBP binding loops; other site 36809011084 ABC-ATPase subunit interface; other site 36809011085 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 36809011086 Transport protein; Region: actII; TIGR00833 36809011087 MMPL family; Region: MMPL; pfam03176 36809011088 MMPL family; Region: MMPL; pfam03176 36809011089 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 36809011090 homodimer interface [polypeptide binding]; other site 36809011091 substrate-cofactor binding pocket; other site 36809011092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809011093 catalytic residue [active] 36809011094 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 36809011095 active site residue [active] 36809011096 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 36809011097 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 36809011098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 36809011099 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 36809011100 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 36809011101 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 36809011102 Citrate transporter; Region: CitMHS; pfam03600 36809011103 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 36809011104 transmembrane helices; other site 36809011105 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809011106 CoenzymeA binding site [chemical binding]; other site 36809011107 subunit interaction site [polypeptide binding]; other site 36809011108 PHB binding site; other site 36809011109 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 36809011110 GDP-binding site [chemical binding]; other site 36809011111 ACT binding site; other site 36809011112 IMP binding site; other site 36809011113 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 36809011114 Peptidase family M50; Region: Peptidase_M50; pfam02163 36809011115 active site 36809011116 putative substrate binding region [chemical binding]; other site 36809011117 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 36809011118 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 36809011119 active site 36809011120 intersubunit interface [polypeptide binding]; other site 36809011121 zinc binding site [ion binding]; other site 36809011122 Na+ binding site [ion binding]; other site 36809011123 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 36809011124 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 36809011125 active site 36809011126 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 36809011127 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 36809011128 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 36809011129 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809011130 active site 36809011131 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809011132 classical (c) SDRs; Region: SDR_c; cd05233 36809011133 NAD(P) binding site [chemical binding]; other site 36809011134 active site 36809011135 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809011136 Transport protein; Region: actII; TIGR00833 36809011137 MMPL family; Region: MMPL; pfam03176 36809011138 MMPL family; Region: MMPL; cl14618 36809011139 cell division protein ZipA; Provisional; Region: PRK03427 36809011140 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 36809011141 Clp amino terminal domain; Region: Clp_N; pfam02861 36809011142 Clp amino terminal domain; Region: Clp_N; pfam02861 36809011143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809011144 Walker A motif; other site 36809011145 ATP binding site [chemical binding]; other site 36809011146 Walker B motif; other site 36809011147 arginine finger; other site 36809011148 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 36809011149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 36809011150 Walker A motif; other site 36809011151 ATP binding site [chemical binding]; other site 36809011152 Walker B motif; other site 36809011153 arginine finger; other site 36809011154 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 36809011155 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 36809011156 putative hydrophobic ligand binding site [chemical binding]; other site 36809011157 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 36809011158 putative hydrophobic ligand binding site [chemical binding]; other site 36809011159 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 36809011160 putative hydrophobic ligand binding site [chemical binding]; other site 36809011161 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 36809011162 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 36809011163 heme-binding site [chemical binding]; other site 36809011164 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 36809011165 FAD binding pocket [chemical binding]; other site 36809011166 FAD binding motif [chemical binding]; other site 36809011167 phosphate binding motif [ion binding]; other site 36809011168 beta-alpha-beta structure motif; other site 36809011169 NAD binding pocket [chemical binding]; other site 36809011170 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 36809011171 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809011172 DNA binding residues [nucleotide binding] 36809011173 putative dimer interface [polypeptide binding]; other site 36809011174 chaperone protein DnaJ; Provisional; Region: PRK14279 36809011175 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 36809011176 HSP70 interaction site [polypeptide binding]; other site 36809011177 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 36809011178 Zn binding sites [ion binding]; other site 36809011179 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 36809011180 dimer interface [polypeptide binding]; other site 36809011181 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 36809011182 dimer interface [polypeptide binding]; other site 36809011183 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 36809011184 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 36809011185 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 36809011186 nucleotide binding site [chemical binding]; other site 36809011187 NEF interaction site [polypeptide binding]; other site 36809011188 SBD interface [polypeptide binding]; other site 36809011189 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 36809011190 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 36809011191 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 36809011192 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 36809011193 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 36809011194 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 36809011195 G1 box; other site 36809011196 GTP/Mg2+ binding site [chemical binding]; other site 36809011197 G2 box; other site 36809011198 Switch I region; other site 36809011199 G3 box; other site 36809011200 Switch II region; other site 36809011201 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 36809011202 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 36809011203 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 36809011204 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 36809011205 G1 box; other site 36809011206 G1 box; other site 36809011207 G1 box; other site 36809011208 GTP/Mg2+ binding site [chemical binding]; other site 36809011209 GTP/Mg2+ binding site [chemical binding]; other site 36809011210 GTP/Mg2+ binding site [chemical binding]; other site 36809011211 G2 box; other site 36809011212 G2 box; other site 36809011213 Switch I region; other site 36809011214 Switch I region; other site 36809011215 G3 box; other site 36809011216 G3 box; other site 36809011217 Switch II region; other site 36809011218 Switch II region; other site 36809011219 G4 box; other site 36809011220 G5 box; other site 36809011221 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 36809011222 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 36809011223 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 36809011224 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 36809011225 Thioredoxin; Region: Thioredoxin_4; pfam13462 36809011226 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 36809011227 Penicillinase repressor; Region: Penicillinase_R; pfam03965 36809011228 Peptidase family M48; Region: Peptidase_M48; cl12018 36809011229 Predicted membrane protein [Function unknown]; Region: COG2259 36809011230 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 36809011231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809011232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809011233 DNA binding residues [nucleotide binding] 36809011234 dimerization interface [polypeptide binding]; other site 36809011235 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 36809011236 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 36809011237 Cysteine-rich domain; Region: CCG; pfam02754 36809011238 Cysteine-rich domain; Region: CCG; pfam02754 36809011239 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 36809011240 aminotransferase AlaT; Validated; Region: PRK09265 36809011241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 36809011242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809011243 homodimer interface [polypeptide binding]; other site 36809011244 catalytic residue [active] 36809011245 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 36809011246 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 36809011247 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 36809011248 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 36809011249 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 36809011250 trimer interface [polypeptide binding]; other site 36809011251 active site 36809011252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 36809011253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 36809011254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809011255 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809011256 alpha-galactosidase; Region: PLN02229 36809011257 alpha-galactosidase; Region: PLN02808; cl17638 36809011258 Uncharacterized conserved protein [Function unknown]; Region: COG1262 36809011259 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 36809011260 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 36809011261 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 36809011262 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 36809011263 Sulfatase; Region: Sulfatase; pfam00884 36809011264 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 36809011265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 36809011266 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 36809011267 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 36809011268 Transport protein; Region: actII; TIGR00833 36809011269 MMPL family; Region: MMPL; pfam03176 36809011270 MMPL family; Region: MMPL; pfam03176 36809011271 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809011272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011274 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 36809011275 NAD binding site [chemical binding]; other site 36809011276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809011279 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 36809011280 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 36809011281 NAD(P) binding site [chemical binding]; other site 36809011282 catalytic residues [active] 36809011283 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 36809011284 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 36809011285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 36809011286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809011287 Coenzyme A binding pocket [chemical binding]; other site 36809011288 ribonuclease E; Reviewed; Region: rne; PRK10811 36809011289 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809011290 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809011291 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 36809011292 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 36809011293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011294 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 36809011295 Zn binding site [ion binding]; other site 36809011296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011298 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 36809011299 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 36809011300 putative ligand binding site [chemical binding]; other site 36809011301 putative NAD binding site [chemical binding]; other site 36809011302 catalytic site [active] 36809011303 short chain dehydrogenase; Provisional; Region: PRK07825 36809011304 classical (c) SDRs; Region: SDR_c; cd05233 36809011305 NAD(P) binding site [chemical binding]; other site 36809011306 active site 36809011307 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809011308 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809011309 active site 36809011310 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 36809011311 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809011312 active site 36809011313 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 36809011314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809011315 nucleophilic elbow; other site 36809011316 catalytic triad; other site 36809011317 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809011318 hydrophobic ligand binding site; other site 36809011319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809011320 acyl-CoA synthetase; Validated; Region: PRK07788 36809011321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809011322 acyl-activating enzyme (AAE) consensus motif; other site 36809011323 AMP binding site [chemical binding]; other site 36809011324 active site 36809011325 CoA binding site [chemical binding]; other site 36809011326 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 36809011327 nucleotide binding site [chemical binding]; other site 36809011328 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 36809011329 nudix motif; other site 36809011330 Transcription factor WhiB; Region: Whib; pfam02467 36809011331 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202 36809011332 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809011333 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809011334 inhibitor-cofactor binding pocket; inhibition site 36809011335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809011336 catalytic residue [active] 36809011337 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 36809011338 tetrameric interface [polypeptide binding]; other site 36809011339 NAD binding site [chemical binding]; other site 36809011340 catalytic residues [active] 36809011341 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 36809011342 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 36809011343 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 36809011344 putative active site [active] 36809011345 catalytic triad [active] 36809011346 putative dimer interface [polypeptide binding]; other site 36809011347 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 36809011348 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 36809011349 Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978 36809011350 Secretory lipase; Region: LIP; pfam03583 36809011351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011353 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809011354 CoenzymeA binding site [chemical binding]; other site 36809011355 subunit interaction site [polypeptide binding]; other site 36809011356 PHB binding site; other site 36809011357 malonic semialdehyde reductase; Provisional; Region: PRK05365 36809011358 FMN binding site [chemical binding]; other site 36809011359 dimer interface [polypeptide binding]; other site 36809011360 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 36809011361 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 36809011362 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 36809011363 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 36809011364 dimer interface [polypeptide binding]; other site 36809011365 PYR/PP interface [polypeptide binding]; other site 36809011366 TPP binding site [chemical binding]; other site 36809011367 substrate binding site [chemical binding]; other site 36809011368 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 36809011369 TPP-binding site [chemical binding]; other site 36809011370 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 36809011371 hypothetical protein; Provisional; Region: PRK06126 36809011372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809011373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 36809011374 active site 36809011375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011377 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 36809011378 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 36809011379 AMP-binding domain protein; Validated; Region: PRK07529 36809011380 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809011381 acyl-activating enzyme (AAE) consensus motif; other site 36809011382 AMP binding site [chemical binding]; other site 36809011383 active site 36809011384 CoA binding site [chemical binding]; other site 36809011385 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809011386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809011387 non-specific DNA binding site [nucleotide binding]; other site 36809011388 salt bridge; other site 36809011389 sequence-specific DNA binding site [nucleotide binding]; other site 36809011390 Cupin domain; Region: Cupin_2; cl17218 36809011391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 36809011392 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 36809011393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809011394 NAD(P) binding site [chemical binding]; other site 36809011395 active site 36809011396 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809011397 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809011398 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 36809011399 catalytic site [active] 36809011400 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 36809011401 inter-subunit interface; other site 36809011402 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 36809011403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809011404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809011405 Reductase C-terminal; Region: Reductase_C; pfam14759 36809011406 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 36809011407 [2Fe-2S] cluster binding site [ion binding]; other site 36809011408 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 36809011409 iron-sulfur cluster [ion binding]; other site 36809011410 [2Fe-2S] cluster binding site [ion binding]; other site 36809011411 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 36809011412 beta subunit interface [polypeptide binding]; other site 36809011413 alpha subunit interface [polypeptide binding]; other site 36809011414 active site 36809011415 substrate binding site [chemical binding]; other site 36809011416 Fe binding site [ion binding]; other site 36809011417 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 36809011418 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809011419 NAD(P) binding site [chemical binding]; other site 36809011420 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 36809011421 putative active site [active] 36809011422 Fe(II) binding site [ion binding]; other site 36809011423 putative dimer interface [polypeptide binding]; other site 36809011424 putative tetramer interface [polypeptide binding]; other site 36809011425 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 36809011426 acetaldehyde dehydrogenase; Validated; Region: PRK08300 36809011427 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 36809011428 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 36809011429 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 36809011430 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 36809011431 active site 36809011432 catalytic residues [active] 36809011433 metal binding site [ion binding]; metal-binding site 36809011434 DmpG-like communication domain; Region: DmpG_comm; pfam07836 36809011435 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 36809011436 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809011437 acyl-activating enzyme (AAE) consensus motif; other site 36809011438 AMP binding site [chemical binding]; other site 36809011439 active site 36809011440 CoA binding site [chemical binding]; other site 36809011441 AMP-binding domain protein; Validated; Region: PRK08315 36809011442 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 36809011443 acyl-activating enzyme (AAE) consensus motif; other site 36809011444 putative AMP binding site [chemical binding]; other site 36809011445 putative active site [active] 36809011446 putative CoA binding site [chemical binding]; other site 36809011447 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 36809011448 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 36809011449 putative active site [active] 36809011450 putative catalytic site [active] 36809011451 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809011452 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 36809011453 Bacterial transcriptional regulator; Region: IclR; pfam01614 36809011454 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 36809011455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809011456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 36809011457 dimerization interface [polypeptide binding]; other site 36809011458 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 36809011459 MMPL family; Region: MMPL; pfam03176 36809011460 Snf7; Region: Snf7; cl19390 36809011461 MMPL family; Region: MMPL; pfam03176 36809011462 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809011463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011465 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809011466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809011467 NAD(P) binding site [chemical binding]; other site 36809011468 active site 36809011469 Lysine efflux permease [General function prediction only]; Region: COG1279 36809011470 GXWXG protein; Region: GXWXG; pfam14231 36809011471 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 36809011472 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 36809011473 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 36809011474 catalytic Zn binding site [ion binding]; other site 36809011475 NAD binding site [chemical binding]; other site 36809011476 structural Zn binding site [ion binding]; other site 36809011477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011479 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 36809011480 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 36809011481 intersubunit interface [polypeptide binding]; other site 36809011482 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 36809011483 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 36809011484 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 36809011485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809011486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809011487 Coenzyme A binding pocket [chemical binding]; other site 36809011488 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 36809011489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809011490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809011491 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 36809011492 putative substrate binding pocket [chemical binding]; other site 36809011493 putative dimerization interface [polypeptide binding]; other site 36809011494 Uncharacterized conserved protein [Function unknown]; Region: COG3391 36809011495 TIGR03032 family protein; Region: TIGR03032 36809011496 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 36809011497 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 36809011498 putative dimer interface [polypeptide binding]; other site 36809011499 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 36809011500 homodimer interface [polypeptide binding]; other site 36809011501 putative substrate binding pocket [chemical binding]; other site 36809011502 diiron center [ion binding]; other site 36809011503 Cutinase; Region: Cutinase; pfam01083 36809011504 Cutinase; Region: Cutinase; pfam01083 36809011505 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 36809011506 catalytic triad [active] 36809011507 conserved cis-peptide bond; other site 36809011508 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 36809011509 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809011510 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 36809011511 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 36809011512 dimer interface [polypeptide binding]; other site 36809011513 decamer (pentamer of dimers) interface [polypeptide binding]; other site 36809011514 catalytic triad [active] 36809011515 peroxidatic and resolving cysteines [active] 36809011516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809011517 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 36809011518 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 36809011519 dimerization interface [polypeptide binding]; other site 36809011520 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 36809011521 tetramer interface [polypeptide binding]; other site 36809011522 active site 36809011523 Mg2+/Mn2+ binding site [ion binding]; other site 36809011524 Transcriptional regulators [Transcription]; Region: GntR; COG1802 36809011525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809011526 DNA-binding site [nucleotide binding]; DNA binding site 36809011527 FCD domain; Region: FCD; pfam07729 36809011528 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 36809011529 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 36809011530 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 36809011531 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 36809011532 NAD binding site [chemical binding]; other site 36809011533 ligand binding site [chemical binding]; other site 36809011534 catalytic site [active] 36809011535 putative amidase; Provisional; Region: PRK06169 36809011536 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 36809011537 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 36809011538 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 36809011539 inhibitor-cofactor binding pocket; inhibition site 36809011540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 36809011541 catalytic residue [active] 36809011542 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 36809011543 tetramerization interface [polypeptide binding]; other site 36809011544 NAD(P) binding site [chemical binding]; other site 36809011545 catalytic residues [active] 36809011546 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 36809011547 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 36809011548 L-aspartate oxidase; Provisional; Region: PRK06175 36809011549 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 36809011550 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 36809011551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 36809011552 catalytic loop [active] 36809011553 iron binding site [ion binding]; other site 36809011554 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 36809011555 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 36809011556 hydrophobic ligand binding site; other site 36809011557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809011558 dimerization interface [polypeptide binding]; other site 36809011559 putative DNA binding site [nucleotide binding]; other site 36809011560 putative Zn2+ binding site [ion binding]; other site 36809011561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809011562 dimerization interface [polypeptide binding]; other site 36809011563 putative DNA binding site [nucleotide binding]; other site 36809011564 putative Zn2+ binding site [ion binding]; other site 36809011565 short chain dehydrogenase; Validated; Region: PRK08264 36809011566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809011567 NAD(P) binding site [chemical binding]; other site 36809011568 active site 36809011569 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 36809011570 Putative oxalocrotonate tautomerase enzyme; Region: Tautomerase_3; pfam14832 36809011571 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 36809011572 enoyl-CoA hydratase; Provisional; Region: PRK07509 36809011573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809011574 substrate binding site [chemical binding]; other site 36809011575 oxyanion hole (OAH) forming residues; other site 36809011576 trimer interface [polypeptide binding]; other site 36809011577 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 36809011578 Spumavirus gag protein; Region: Gag_spuma; pfam03276 36809011579 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 36809011580 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 36809011581 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 36809011582 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 36809011583 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 36809011584 active site 36809011585 ATP binding site [chemical binding]; other site 36809011586 substrate binding site [chemical binding]; other site 36809011587 activation loop (A-loop); other site 36809011588 Protein of unknown function (DUF664); Region: DUF664; pfam04978 36809011589 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 36809011590 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 36809011591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809011592 active site 36809011593 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 36809011594 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809011595 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809011596 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 36809011597 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 36809011598 AAA domain; Region: AAA_18; pfam13238 36809011599 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 36809011600 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 36809011601 Moco binding site; other site 36809011602 metal coordination site [ion binding]; other site 36809011603 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 36809011604 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 36809011605 dimer interface [polypeptide binding]; other site 36809011606 active site 36809011607 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 36809011608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809011609 NAD(P) binding site [chemical binding]; other site 36809011610 active site 36809011611 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809011612 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809011613 active site 2 [active] 36809011614 active site 1 [active] 36809011615 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809011616 TIGR03086 family protein; Region: TIGR03086 36809011617 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 36809011618 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 36809011619 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 36809011620 Sulfate transporter family; Region: Sulfate_transp; pfam00916 36809011621 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 36809011622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011624 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 36809011625 Predicted metal-dependent hydrolase; Region: Metal_hydrol; cl19844 36809011626 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 36809011627 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809011628 DNA binding residues [nucleotide binding] 36809011629 YCII-related domain; Region: YCII; cl00999 36809011630 YCII-related domain; Region: YCII; cl00999 36809011631 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 36809011632 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 36809011633 acyl-activating enzyme (AAE) consensus motif; other site 36809011634 active site 36809011635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809011636 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809011637 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 36809011638 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 36809011639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809011640 Proteins of 100 residues with WXG; Region: WXG100; cl02005 36809011641 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 36809011642 Restriction endonuclease fold toxin 7; Region: Tox-REase-7; pfam15649 36809011643 HEAT repeats; Region: HEAT_2; pfam13646 36809011644 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 36809011645 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 36809011646 Sulfatase; Region: Sulfatase; pfam00884 36809011647 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 36809011648 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 36809011649 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 36809011650 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 36809011651 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 36809011652 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 36809011653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809011654 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 36809011655 dinuclear metal binding motif [ion binding]; other site 36809011656 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 36809011657 classical (c) SDRs; Region: SDR_c; cd05233 36809011658 NAD(P) binding site [chemical binding]; other site 36809011659 active site 36809011660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011661 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809011662 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cl00230 36809011663 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 36809011664 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 36809011665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809011666 S-adenosylmethionine binding site [chemical binding]; other site 36809011667 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 36809011668 putative active site [active] 36809011669 putative substrate binding site [chemical binding]; other site 36809011670 ATP binding site [chemical binding]; other site 36809011671 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 36809011672 NAD binding site [chemical binding]; other site 36809011673 catalytic residues [active] 36809011674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809011675 metabolite-proton symporter; Region: 2A0106; TIGR00883 36809011676 putative substrate translocation pore; other site 36809011677 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 36809011678 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 36809011679 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 36809011680 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 36809011681 Uncharacterized conserved protein [Function unknown]; Region: COG2128 36809011682 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 36809011683 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 36809011684 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 36809011685 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 36809011686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809011687 NAD(P) binding site [chemical binding]; other site 36809011688 active site 36809011689 Cupin domain; Region: Cupin_2; cl17218 36809011690 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 36809011691 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809011692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809011693 putative Zn2+ binding site [ion binding]; other site 36809011694 Bacterial transcriptional regulator; Region: IclR; pfam01614 36809011695 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 36809011696 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 36809011697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809011698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809011699 active site 36809011700 phosphorylation site [posttranslational modification] 36809011701 intermolecular recognition site; other site 36809011702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809011703 DNA binding residues [nucleotide binding] 36809011704 dimerization interface [polypeptide binding]; other site 36809011705 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 36809011706 Histidine kinase; Region: HisKA_3; pfam07730 36809011707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809011708 ATP binding site [chemical binding]; other site 36809011709 Mg2+ binding site [ion binding]; other site 36809011710 G-X-G motif; other site 36809011711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809011712 putative substrate translocation pore; other site 36809011713 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 36809011714 active site 36809011715 substrate-binding site [chemical binding]; other site 36809011716 metal-binding site [ion binding] 36809011717 GTP binding site [chemical binding]; other site 36809011718 Mitochondrial 28S ribosomal protein S27; Region: MRP-S27; pfam10037 36809011719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809011720 S-adenosylmethionine binding site [chemical binding]; other site 36809011721 LabA_like proteins; Region: LabA_like; cd06167 36809011722 putative metal binding site [ion binding]; other site 36809011723 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 36809011724 MMPL family; Region: MMPL; cl14618 36809011725 MMPL family; Region: MMPL; cl14618 36809011726 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 36809011727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011729 WHG domain; Region: WHG; pfam13305 36809011730 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011731 mce related protein; Region: MCE; pfam02470 36809011732 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011733 mce related protein; Region: MCE; pfam02470 36809011734 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 36809011735 mce related protein; Region: MCE; pfam02470 36809011736 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 36809011737 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011738 mce related protein; Region: MCE; pfam02470 36809011739 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011740 mce related protein; Region: MCE; pfam02470 36809011741 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011742 mce related protein; Region: MCE; pfam02470 36809011743 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 36809011744 Permease; Region: Permease; pfam02405 36809011745 Permease; Region: Permease; pfam02405 36809011746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 36809011747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809011748 active site 36809011749 phosphorylation site [posttranslational modification] 36809011750 intermolecular recognition site; other site 36809011751 dimerization interface [polypeptide binding]; other site 36809011752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 36809011753 DNA binding residues [nucleotide binding] 36809011754 dimerization interface [polypeptide binding]; other site 36809011755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 36809011756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 36809011757 ATP binding site [chemical binding]; other site 36809011758 Mg2+ binding site [ion binding]; other site 36809011759 G-X-G motif; other site 36809011760 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 36809011761 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809011762 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809011763 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809011764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 36809011765 dimerization interface [polypeptide binding]; other site 36809011766 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 36809011767 cyclase homology domain; Region: CHD; cd07302 36809011768 nucleotidyl binding site; other site 36809011769 metal binding site [ion binding]; metal-binding site 36809011770 dimer interface [polypeptide binding]; other site 36809011771 Predicted integral membrane protein [Function unknown]; Region: COG0392 36809011772 Uncharacterized conserved protein [Function unknown]; Region: COG2353 36809011773 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 36809011774 Protein of unknown function (DUF4106); Region: DUF4106; pfam13388 36809011775 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 36809011776 MMPL family; Region: MMPL; cl14618 36809011777 MMPL family; Region: MMPL; cl14618 36809011778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809011779 non-specific DNA binding site [nucleotide binding]; other site 36809011780 salt bridge; other site 36809011781 sequence-specific DNA binding site [nucleotide binding]; other site 36809011782 Interferon-induced transmembrane protein; Region: Dispanin; pfam04505 36809011783 hypothetical protein; Provisional; Region: PRK01346 36809011784 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 36809011785 Sterol carrier protein domain; Region: SCP2_2; pfam13530 36809011786 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 36809011787 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 36809011788 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 36809011789 active site 36809011790 Zn binding site [ion binding]; other site 36809011791 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 36809011792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 36809011793 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 36809011794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809011795 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809011796 active site 36809011797 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 36809011798 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 36809011799 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 36809011800 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 36809011801 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 36809011802 carboxyltransferase (CT) interaction site; other site 36809011803 biotinylation site [posttranslational modification]; other site 36809011804 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 36809011805 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 36809011806 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809011807 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809011808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011810 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 36809011811 putative homodimer interface [polypeptide binding]; other site 36809011812 putative homotetramer interface [polypeptide binding]; other site 36809011813 putative allosteric switch controlling residues; other site 36809011814 putative metal binding site [ion binding]; other site 36809011815 putative homodimer-homodimer interface [polypeptide binding]; other site 36809011816 Domain of unknown function (DUF305); Region: DUF305; pfam03713 36809011817 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 36809011818 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 36809011819 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 36809011820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011822 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 36809011823 NAD(P) binding site [chemical binding]; other site 36809011824 catalytic residues [active] 36809011825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809011826 S-adenosylmethionine binding site [chemical binding]; other site 36809011827 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 36809011828 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 36809011829 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 36809011830 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 36809011831 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 36809011832 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 36809011833 RNA polymerase factor sigma-70; Validated; Region: PRK08241 36809011834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809011835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809011836 DNA binding residues [nucleotide binding] 36809011837 SnoaL-like domain; Region: SnoaL_2; pfam12680 36809011838 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 36809011839 Zn binding site [ion binding]; other site 36809011840 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 36809011841 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 36809011842 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 36809011843 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 36809011844 acyl-activating enzyme (AAE) consensus motif; other site 36809011845 putative AMP binding site [chemical binding]; other site 36809011846 putative active site [active] 36809011847 putative CoA binding site [chemical binding]; other site 36809011848 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 36809011849 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 36809011850 NAD binding site [chemical binding]; other site 36809011851 catalytic Zn binding site [ion binding]; other site 36809011852 substrate binding site [chemical binding]; other site 36809011853 structural Zn binding site [ion binding]; other site 36809011854 Pirin-related protein [General function prediction only]; Region: COG1741 36809011855 Pirin; Region: Pirin; pfam02678 36809011856 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 36809011857 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011858 mce related protein; Region: MCE; pfam02470 36809011859 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011860 mce related protein; Region: MCE; pfam02470 36809011861 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011862 mce related protein; Region: MCE; pfam02470 36809011863 Peptidase S24-like; Region: Peptidase_S24; pfam00717 36809011864 Protein of unknown function (DUF2397); Region: DUF2397; cl19578 36809011865 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011866 mce related protein; Region: MCE; pfam02470 36809011867 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011868 mce related protein; Region: MCE; pfam02470 36809011869 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011870 mce related protein; Region: MCE; pfam02470 36809011871 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 36809011872 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 36809011873 acyl-activating enzyme (AAE) consensus motif; other site 36809011874 putative AMP binding site [chemical binding]; other site 36809011875 putative active site [active] 36809011876 putative CoA binding site [chemical binding]; other site 36809011877 enoyl-CoA hydratase; Provisional; Region: PRK06688 36809011878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809011879 substrate binding site [chemical binding]; other site 36809011880 oxyanion hole (OAH) forming residues; other site 36809011881 trimer interface [polypeptide binding]; other site 36809011882 Transcriptional regulators [Transcription]; Region: GntR; COG1802 36809011883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809011884 DNA-binding site [nucleotide binding]; DNA binding site 36809011885 FCD domain; Region: FCD; pfam07729 36809011886 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 36809011887 putative hydrophobic ligand binding site [chemical binding]; other site 36809011888 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 36809011889 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809011890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011892 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 36809011893 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 36809011894 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 36809011895 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 36809011896 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 36809011897 ligand binding site [chemical binding]; other site 36809011898 homodimer interface [polypeptide binding]; other site 36809011899 NAD(P) binding site [chemical binding]; other site 36809011900 trimer interface B [polypeptide binding]; other site 36809011901 trimer interface A [polypeptide binding]; other site 36809011902 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 36809011903 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 36809011904 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 36809011905 putative dimer interface [polypeptide binding]; other site 36809011906 N-terminal domain interface [polypeptide binding]; other site 36809011907 putative substrate binding pocket (H-site) [chemical binding]; other site 36809011908 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 36809011909 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 36809011910 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 36809011911 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 36809011912 enoyl-CoA hydratase; Provisional; Region: PRK08252 36809011913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 36809011914 substrate binding site [chemical binding]; other site 36809011915 oxyanion hole (OAH) forming residues; other site 36809011916 trimer interface [polypeptide binding]; other site 36809011917 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 36809011918 Phosphotransferase enzyme family; Region: APH; pfam01636 36809011919 putative active site [active] 36809011920 putative substrate binding site [chemical binding]; other site 36809011921 ATP binding site [chemical binding]; other site 36809011922 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 36809011923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809011924 putative substrate translocation pore; other site 36809011925 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 36809011926 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 36809011927 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 36809011928 Protein of unknown function (DUF456); Region: DUF456; pfam04306 36809011929 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011930 mce related protein; Region: MCE; pfam02470 36809011931 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011932 mce related protein; Region: MCE; pfam02470 36809011933 mce related protein; Region: MCE; pfam02470 36809011934 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011935 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011936 mce related protein; Region: MCE; pfam02470 36809011937 mce related protein; Region: MCE; pfam02470 36809011938 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 36809011939 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 36809011940 mce related protein; Region: MCE; pfam02470 36809011941 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 36809011942 Permease; Region: Permease; pfam02405 36809011943 Permease; Region: Permease; pfam02405 36809011944 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 36809011945 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 36809011946 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 36809011947 NAD(P) binding site [chemical binding]; other site 36809011948 short chain dehydrogenase; Provisional; Region: PRK07791 36809011949 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 36809011950 NAD binding site [chemical binding]; other site 36809011951 homodimer interface [polypeptide binding]; other site 36809011952 active site 36809011953 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 36809011954 NAD(P) binding site [chemical binding]; other site 36809011955 catalytic residues [active] 36809011956 Leucine carboxyl methyltransferase; Region: LCM; cl01306 36809011957 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 36809011958 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 36809011959 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 36809011960 dimer interface [polypeptide binding]; other site 36809011961 active site 36809011962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809011963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809011964 active site 36809011965 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 36809011966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809011967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809011968 Domain of unknown function (DUF427); Region: DUF427; pfam04248 36809011969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809011970 S-adenosylmethionine binding site [chemical binding]; other site 36809011971 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809011972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809011973 putative substrate translocation pore; other site 36809011974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809011975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809011976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809011977 sequence-specific DNA binding site [nucleotide binding]; other site 36809011978 salt bridge; other site 36809011979 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 36809011980 Domain of unknown function (DUF955); Region: DUF955; pfam06114 36809011981 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 36809011982 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 36809011983 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 36809011984 tetramer interface [polypeptide binding]; other site 36809011985 active site 36809011986 Mg2+/Mn2+ binding site [ion binding]; other site 36809011987 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 36809011988 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 36809011989 dimer interface [polypeptide binding]; other site 36809011990 active site 36809011991 citrylCoA binding site [chemical binding]; other site 36809011992 oxalacetate/citrate binding site [chemical binding]; other site 36809011993 coenzyme A binding site [chemical binding]; other site 36809011994 catalytic triad [active] 36809011995 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 36809011996 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 36809011997 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 36809011998 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 36809011999 THF binding site; other site 36809012000 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 36809012001 substrate binding site [chemical binding]; other site 36809012002 THF binding site; other site 36809012003 zinc-binding site [ion binding]; other site 36809012004 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 36809012005 CoenzymeA binding site [chemical binding]; other site 36809012006 subunit interaction site [polypeptide binding]; other site 36809012007 PHB binding site; other site 36809012008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012010 acyl-CoA synthetase; Validated; Region: PRK06188 36809012011 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 36809012012 putative active site [active] 36809012013 putative CoA binding site [chemical binding]; other site 36809012014 putative AMP binding site [chemical binding]; other site 36809012015 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 36809012016 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 36809012017 active site 36809012018 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 36809012019 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 36809012020 Transcriptional regulator [Transcription]; Region: IclR; COG1414 36809012021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809012022 putative DNA binding site [nucleotide binding]; other site 36809012023 putative Zn2+ binding site [ion binding]; other site 36809012024 short chain dehydrogenase; Provisional; Region: PRK07814 36809012025 classical (c) SDRs; Region: SDR_c; cd05233 36809012026 NAD(P) binding site [chemical binding]; other site 36809012027 active site 36809012028 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 36809012029 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 36809012030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012031 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809012032 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 36809012033 putative active site [active] 36809012034 putative FMN binding site [chemical binding]; other site 36809012035 putative substrate binding site [chemical binding]; other site 36809012036 putative catalytic residue [active] 36809012037 Domain of unknown function (DUF385); Region: DUF385; cl04387 36809012038 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 36809012039 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 36809012040 nucleotide binding site/active site [active] 36809012041 HIT family signature motif; other site 36809012042 catalytic residue [active] 36809012043 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 36809012044 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 36809012045 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 36809012046 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 36809012047 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 36809012048 Na binding site [ion binding]; other site 36809012049 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 36809012050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809012051 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809012052 sequence-specific DNA binding site [nucleotide binding]; other site 36809012053 salt bridge; other site 36809012054 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 36809012055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 36809012056 dimer interface [polypeptide binding]; other site 36809012057 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 36809012058 active site 36809012059 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 36809012060 substrate binding site [chemical binding]; other site 36809012061 catalytic residue [active] 36809012062 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 36809012063 Transcriptional regulators [Transcription]; Region: FadR; COG2186 36809012064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 36809012065 DNA-binding site [nucleotide binding]; DNA binding site 36809012066 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 36809012067 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 36809012068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012072 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 36809012073 hydrophobic ligand binding site; other site 36809012074 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 36809012075 active site 36809012076 catalytic residues [active] 36809012077 metal binding site [ion binding]; metal-binding site 36809012078 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 36809012079 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 36809012080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809012081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 36809012082 DNA binding residues [nucleotide binding] 36809012083 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 36809012084 iron-sulfur cluster [ion binding]; other site 36809012085 [2Fe-2S] cluster binding site [ion binding]; other site 36809012086 Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; Region: Amicyanin; cd13921 36809012087 Type 1 (T1) Cu binding site [ion binding]; other site 36809012088 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 36809012089 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 36809012090 active site 36809012091 metal binding site [ion binding]; metal-binding site 36809012092 short chain dehydrogenase; Provisional; Region: PRK12744 36809012093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809012094 NAD(P) binding site [chemical binding]; other site 36809012095 active site 36809012096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809012097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809012098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 36809012099 dimerization interface [polypeptide binding]; other site 36809012100 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809012101 active site 36809012102 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 36809012103 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 36809012104 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 36809012105 CGNR zinc finger; Region: zf-CGNR; pfam11706 36809012106 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 36809012107 classical (c) SDRs; Region: SDR_c; cd05233 36809012108 NAD(P) binding site [chemical binding]; other site 36809012109 active site 36809012110 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 36809012111 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 36809012112 active site 36809012113 acyl-CoA synthetase; Validated; Region: PRK09192 36809012114 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809012115 acyl-activating enzyme (AAE) consensus motif; other site 36809012116 AMP binding site [chemical binding]; other site 36809012117 active site 36809012118 CoA binding site [chemical binding]; other site 36809012119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012120 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 36809012121 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 36809012122 Walker A/P-loop; other site 36809012123 ATP binding site [chemical binding]; other site 36809012124 Q-loop/lid; other site 36809012125 ABC transporter signature motif; other site 36809012126 Walker B; other site 36809012127 D-loop; other site 36809012128 H-loop/switch region; other site 36809012129 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 36809012130 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 36809012131 FtsX-like permease family; Region: FtsX; pfam02687 36809012132 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 36809012133 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 36809012134 catalytic residue [active] 36809012135 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 36809012136 trimerization site [polypeptide binding]; other site 36809012137 active site 36809012138 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 36809012139 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 36809012140 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809012141 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 36809012142 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809012143 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 36809012144 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809012145 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 36809012146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809012147 NAD(P) binding site [chemical binding]; other site 36809012148 active site 36809012149 NlpC/P60 family; Region: NLPC_P60; cl17555 36809012150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012151 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 36809012152 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 36809012153 TDP-binding site; other site 36809012154 tetracycline repressor protein TetR; Provisional; Region: PRK13756 36809012155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012156 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 36809012157 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 36809012158 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012159 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 36809012160 acyl-activating enzyme (AAE) consensus motif; other site 36809012161 AMP binding site [chemical binding]; other site 36809012162 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012163 Condensation domain; Region: Condensation; pfam00668 36809012164 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809012165 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809012166 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012167 acyl-activating enzyme (AAE) consensus motif; other site 36809012168 AMP binding site [chemical binding]; other site 36809012169 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012170 Condensation domain; Region: Condensation; cl19241 36809012171 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809012172 Condensation domain; Region: Condensation; pfam00668 36809012173 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809012174 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012175 peptide synthase; Provisional; Region: PRK12316 36809012176 Condensation domain; Region: Condensation; cl19241 36809012177 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012178 acyl-activating enzyme (AAE) consensus motif; other site 36809012179 AMP binding site [chemical binding]; other site 36809012180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012181 Condensation domain; Region: Condensation; cl19241 36809012182 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809012183 Condensation domain; Region: Condensation; cl19241 36809012184 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012185 acyl-activating enzyme (AAE) consensus motif; other site 36809012186 AMP binding site [chemical binding]; other site 36809012187 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012188 Condensation domain; Region: Condensation; pfam00668 36809012189 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809012190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012191 acyl-activating enzyme (AAE) consensus motif; other site 36809012192 AMP binding site [chemical binding]; other site 36809012193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012194 Condensation domain; Region: Condensation; cl19241 36809012195 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809012196 Condensation domain; Region: Condensation; pfam00668 36809012197 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809012198 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012199 acyl-activating enzyme (AAE) consensus motif; other site 36809012200 AMP binding site [chemical binding]; other site 36809012201 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012202 Condensation domain; Region: Condensation; pfam00668 36809012203 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809012204 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809012205 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012206 acyl-activating enzyme (AAE) consensus motif; other site 36809012207 AMP binding site [chemical binding]; other site 36809012208 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012209 Condensation domain; Region: Condensation; pfam00668 36809012210 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809012211 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809012212 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 36809012213 acyl-activating enzyme (AAE) consensus motif; other site 36809012214 AMP binding site [chemical binding]; other site 36809012215 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012216 Condensation domain; Region: Condensation; cl19241 36809012217 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 36809012218 Condensation domain; Region: Condensation; pfam00668 36809012219 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 36809012220 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 36809012221 MbtH-like protein; Region: MbtH; pfam03621 36809012222 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 36809012223 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 36809012224 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 36809012225 homodimer interface [polypeptide binding]; other site 36809012226 active site 36809012227 TDP-binding site; other site 36809012228 acceptor substrate-binding pocket; other site 36809012229 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 36809012230 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 36809012231 homodimer interface [polypeptide binding]; other site 36809012232 active site 36809012233 TDP-binding site; other site 36809012234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809012235 S-adenosylmethionine binding site [chemical binding]; other site 36809012236 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 36809012237 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 36809012238 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 36809012239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 36809012240 Transport protein; Region: actII; TIGR00833 36809012241 MMPL family; Region: MMPL; pfam03176 36809012242 MMPL family; Region: MMPL; pfam03176 36809012243 Transport protein; Region: actII; TIGR00833 36809012244 MMPL family; Region: MMPL; pfam03176 36809012245 MMPL family; Region: MMPL; pfam03176 36809012246 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809012247 Secretory lipase; Region: LIP; pfam03583 36809012248 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 36809012249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809012250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 36809012251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809012252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 36809012253 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 36809012254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809012255 NAD(P) binding site [chemical binding]; other site 36809012256 active site 36809012257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809012258 Helix-turn-helix domain; Region: HTH_18; pfam12833 36809012259 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 36809012260 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 36809012261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 36809012262 acyl-activating enzyme (AAE) consensus motif; other site 36809012263 AMP binding site [chemical binding]; other site 36809012264 active site 36809012265 CoA binding site [chemical binding]; other site 36809012266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 36809012267 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 36809012268 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 36809012269 putative NAD(P) binding site [chemical binding]; other site 36809012270 active site 36809012271 putative substrate binding site [chemical binding]; other site 36809012272 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809012273 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 36809012274 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 36809012275 potassium/proton antiporter; Reviewed; Region: PRK05326 36809012276 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 36809012277 TrkA-C domain; Region: TrkA_C; pfam02080 36809012278 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 36809012279 TrkA-N domain; Region: TrkA_N; pfam02254 36809012280 TrkA-C domain; Region: TrkA_C; pfam02080 36809012281 V-type ATP synthase subunit I; Validated; Region: PRK05771 36809012282 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 36809012283 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 36809012284 DNA binding residues [nucleotide binding] 36809012285 dimer interface [polypeptide binding]; other site 36809012286 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 36809012287 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 36809012288 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 36809012289 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 36809012290 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 36809012291 Restriction endonuclease; Region: Mrr_cat; pfam04471 36809012292 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 36809012293 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 36809012294 putative DNA binding site [nucleotide binding]; other site 36809012295 catalytic residue [active] 36809012296 putative H2TH interface [polypeptide binding]; other site 36809012297 putative catalytic residues [active] 36809012298 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 36809012299 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 36809012300 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 36809012301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809012302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809012303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 36809012304 dimerization interface [polypeptide binding]; other site 36809012305 DoxX-like family; Region: DoxX_2; pfam13564 36809012306 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 36809012307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809012308 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 36809012309 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 36809012310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 36809012311 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 36809012312 Ferritin-like domain; Region: Ferritin; pfam00210 36809012313 dimerization interface [polypeptide binding]; other site 36809012314 DPS ferroxidase diiron center [ion binding]; other site 36809012315 ion pore; other site 36809012316 Thioredoxin; Region: Thioredoxin_4; cl17273 36809012317 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 36809012318 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 36809012319 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 36809012320 metal binding site [ion binding]; metal-binding site 36809012321 putative dimer interface [polypeptide binding]; other site 36809012322 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 36809012323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809012324 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 36809012325 active site 36809012326 catalytic residues [active] 36809012327 TQO small subunit DoxD; Region: DoxD; pfam04173 36809012328 TQO small subunit DoxA; Region: DoxA; pfam07680 36809012329 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809012330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809012331 S-adenosylmethionine binding site [chemical binding]; other site 36809012332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 36809012333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809012334 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809012335 Transport protein; Region: actII; TIGR00833 36809012336 MMPL family; Region: MMPL; pfam03176 36809012337 MMPL family; Region: MMPL; pfam03176 36809012338 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 36809012339 putative homodimer interface [polypeptide binding]; other site 36809012340 putative homotetramer interface [polypeptide binding]; other site 36809012341 putative allosteric switch controlling residues; other site 36809012342 putative metal binding site [ion binding]; other site 36809012343 putative homodimer-homodimer interface [polypeptide binding]; other site 36809012344 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 36809012345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012347 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 36809012348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809012349 NAD(P) binding site [chemical binding]; other site 36809012350 active site 36809012351 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 36809012352 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 36809012353 active site 36809012354 nucleophile elbow; other site 36809012355 Domain of unknown function (DUF222); Region: DUF222; pfam02720 36809012356 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 36809012357 active site 36809012358 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 36809012359 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 36809012360 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 36809012361 conserved cys residue [active] 36809012362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 36809012363 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809012364 hypothetical protein; Provisional; Region: PRK06185 36809012365 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809012366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012368 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 36809012369 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 36809012370 active site 36809012371 nucleophile elbow; other site 36809012372 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 36809012373 FMN binding site [chemical binding]; other site 36809012374 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 36809012375 dimer interface [polypeptide binding]; other site 36809012376 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 36809012377 Predicted membrane protein [Function unknown]; Region: COG1511 36809012378 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 36809012379 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 36809012380 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 36809012381 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 36809012382 Predicted metal-dependent hydrolase; Region: Metal_hydrol; cl19844 36809012383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012385 Cupin; Region: Cupin_1; smart00835 36809012386 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 36809012387 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 36809012388 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 36809012389 Transport protein; Region: actII; TIGR00833 36809012390 MMPL family; Region: MMPL; pfam03176 36809012391 MMPL family; Region: MMPL; pfam03176 36809012392 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 36809012393 cyclase homology domain; Region: CHD; cd07302 36809012394 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 36809012395 nucleotidyl binding site; other site 36809012396 metal binding site [ion binding]; metal-binding site 36809012397 dimer interface [polypeptide binding]; other site 36809012398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012400 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 36809012401 heme binding pocket [chemical binding]; other site 36809012402 heme ligand [chemical binding]; other site 36809012403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 36809012404 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 36809012405 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 36809012406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012407 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 36809012408 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 36809012409 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 36809012410 active site 36809012411 catalytic site [active] 36809012412 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 36809012413 active site 2 [active] 36809012414 active site 1 [active] 36809012415 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 36809012416 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809012417 ABC transporter; Region: ABC_tran_2; pfam12848 36809012418 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 36809012419 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 36809012420 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 36809012421 PPE family; Region: PPE; pfam00823 36809012422 DoxX; Region: DoxX; pfam07681 36809012423 Predicted membrane protein [Function unknown]; Region: COG2259 36809012424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012426 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 36809012427 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 36809012428 Alkylmercury lyase; Region: MerB; pfam03243 36809012429 short chain dehydrogenase; Provisional; Region: PRK05866 36809012430 classical (c) SDRs; Region: SDR_c; cd05233 36809012431 NAD(P) binding site [chemical binding]; other site 36809012432 active site 36809012433 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 36809012434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809012435 H+ Antiporter protein; Region: 2A0121; TIGR00900 36809012436 putative substrate translocation pore; other site 36809012437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 36809012438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 36809012439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809012440 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 36809012441 dimerization interface [polypeptide binding]; other site 36809012442 substrate binding pocket [chemical binding]; other site 36809012443 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 36809012444 Esterase/lipase [General function prediction only]; Region: COG1647 36809012445 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 36809012446 Methyltransferase domain; Region: Methyltransf_31; pfam13847 36809012447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809012448 S-adenosylmethionine binding site [chemical binding]; other site 36809012449 Beta-lactamase; Region: Beta-lactamase; pfam00144 36809012450 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 36809012451 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 36809012452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809012453 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 36809012454 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 36809012455 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 36809012456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 36809012457 Putative esterase; Region: Esterase; pfam00756 36809012458 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 36809012459 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 36809012460 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 36809012461 Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]; Region: ARG80; COG5068 36809012462 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 36809012463 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 36809012464 catalytic residues [active] 36809012465 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 36809012466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 36809012467 binding surface 36809012468 TPR motif; other site 36809012469 Tetratricopeptide repeat; Region: TPR_12; pfam13424 36809012470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 36809012471 Putative lysophospholipase; Region: Hydrolase_4; cl19140 36809012472 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 36809012473 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 36809012474 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1; cd01653 36809012475 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 36809012476 Superfamily II helicase [General function prediction only]; Region: COG1204 36809012477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 36809012478 ATP binding site [chemical binding]; other site 36809012479 putative Mg++ binding site [ion binding]; other site 36809012480 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 36809012481 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 36809012482 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 36809012483 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 36809012484 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 36809012485 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 36809012486 Phosphotransferase enzyme family; Region: APH; pfam01636 36809012487 active site 36809012488 substrate binding site [chemical binding]; other site 36809012489 ATP binding site [chemical binding]; other site 36809012490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 36809012491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 36809012492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809012493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809012494 putative substrate translocation pore; other site 36809012495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 36809012496 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809012497 dimerization interface [polypeptide binding]; other site 36809012498 putative DNA binding site [nucleotide binding]; other site 36809012499 putative Zn2+ binding site [ion binding]; other site 36809012500 Low molecular weight phosphatase family; Region: LMWPc; cd00115 36809012501 active site 36809012502 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 36809012503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809012504 dimerization interface [polypeptide binding]; other site 36809012505 putative DNA binding site [nucleotide binding]; other site 36809012506 Transcriptional regulators [Transcription]; Region: MarR; COG1846 36809012507 putative Zn2+ binding site [ion binding]; other site 36809012508 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 36809012509 active site 36809012510 Phosphate transporter family; Region: PHO4; pfam01384 36809012511 Helicase associated domain; Region: HA; pfam03457 36809012512 Helicase associated domain; Region: HA; pfam03457 36809012513 Helicase associated domain; Region: HA; pfam03457 36809012514 Helicase associated domain; Region: HA; pfam03457 36809012515 Helicase associated domain; Region: HA; pfam03457 36809012516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 36809012517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 36809012518 active site 36809012519 phosphorylation site [posttranslational modification] 36809012520 intermolecular recognition site; other site 36809012521 dimerization interface [polypeptide binding]; other site 36809012522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 36809012523 DNA binding site [nucleotide binding] 36809012524 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 36809012525 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 36809012526 Walker A/P-loop; other site 36809012527 ATP binding site [chemical binding]; other site 36809012528 Q-loop/lid; other site 36809012529 ABC transporter signature motif; other site 36809012530 Walker B; other site 36809012531 D-loop; other site 36809012532 H-loop/switch region; other site 36809012533 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 36809012534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809012535 dimer interface [polypeptide binding]; other site 36809012536 conserved gate region; other site 36809012537 putative PBP binding loops; other site 36809012538 ABC-ATPase subunit interface; other site 36809012539 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 36809012540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 36809012541 dimer interface [polypeptide binding]; other site 36809012542 conserved gate region; other site 36809012543 putative PBP binding loops; other site 36809012544 ABC-ATPase subunit interface; other site 36809012545 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 36809012546 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 36809012547 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 36809012548 Soluble P-type ATPase [General function prediction only]; Region: COG4087 36809012549 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809012550 dimerization interface [polypeptide binding]; other site 36809012551 putative DNA binding site [nucleotide binding]; other site 36809012552 putative Zn2+ binding site [ion binding]; other site 36809012553 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 36809012554 Penicillinase repressor; Region: Penicillinase_R; pfam03965 36809012555 Peptidase family M48; Region: Peptidase_M48; cl12018 36809012556 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 36809012557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809012558 dimerization interface [polypeptide binding]; other site 36809012559 putative DNA binding site [nucleotide binding]; other site 36809012560 putative Zn2+ binding site [ion binding]; other site 36809012561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 36809012562 dimerization interface [polypeptide binding]; other site 36809012563 putative DNA binding site [nucleotide binding]; other site 36809012564 putative Zn2+ binding site [ion binding]; other site 36809012565 arsenical-resistance protein; Region: acr3; TIGR00832 36809012566 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 36809012567 active site 36809012568 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 36809012569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809012570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809012571 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 36809012572 BCCT family transporter; Region: BCCT; cl00569 36809012573 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 36809012574 trimer interface [polypeptide binding]; other site 36809012575 active site 36809012576 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809012577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809012578 non-specific DNA binding site [nucleotide binding]; other site 36809012579 salt bridge; other site 36809012580 sequence-specific DNA binding site [nucleotide binding]; other site 36809012581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809012582 sequence-specific DNA binding site [nucleotide binding]; other site 36809012583 salt bridge; other site 36809012584 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 36809012585 active site 36809012586 catalytic residues [active] 36809012587 DNA binding site [nucleotide binding] 36809012588 Int/Topo IB signature motif; other site 36809012589 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 36809012590 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 36809012591 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 36809012592 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 36809012593 active site 36809012594 DNA binding site [nucleotide binding] 36809012595 Int/Topo IB signature motif; other site 36809012596 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 36809012597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 36809012598 non-specific DNA binding site [nucleotide binding]; other site 36809012599 salt bridge; other site 36809012600 sequence-specific DNA binding site [nucleotide binding]; other site 36809012601 Domain of unknown function (DUF955); Region: DUF955; cl01076 36809012602 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 36809012603 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 36809012604 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 36809012605 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 36809012606 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 36809012607 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 36809012608 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 36809012609 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 36809012610 active site 36809012611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 36809012612 active site 36809012613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809012614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 36809012615 putative substrate translocation pore; other site 36809012616 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 36809012617 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 36809012618 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 36809012619 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 36809012620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 36809012621 Coenzyme A binding pocket [chemical binding]; other site 36809012622 TniQ; Region: TniQ; pfam06527 36809012623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 36809012624 AAA domain; Region: AAA_22; pfam13401 36809012625 Homeodomain-like domain; Region: HTH_32; pfam13565 36809012626 Integrase core domain; Region: rve; pfam00665 36809012627 Integrase core domain; Region: rve_3; cl15866 36809012628 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 36809012629 replicative DNA helicase; Region: DnaB; TIGR00665 36809012630 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 36809012631 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 36809012632 Walker A motif; other site 36809012633 ATP binding site [chemical binding]; other site 36809012634 Walker B motif; other site 36809012635 DNA binding loops [nucleotide binding] 36809012636 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 36809012637 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 36809012638 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 36809012639 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 36809012640 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 36809012641 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 36809012642 dimer interface [polypeptide binding]; other site 36809012643 ssDNA binding site [nucleotide binding]; other site 36809012644 tetramer (dimer of dimers) interface [polypeptide binding]; other site 36809012645 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 36809012646 Predicted integral membrane protein [Function unknown]; Region: COG5650 36809012647 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 36809012648 Transglycosylase; Region: Transgly; pfam00912 36809012649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 36809012650 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 36809012651 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 36809012652 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 36809012653 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 36809012654 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 36809012655 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 36809012656 Phosphotransferase enzyme family; Region: APH; pfam01636 36809012657 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 36809012658 putative active site [active] 36809012659 putative substrate binding site [chemical binding]; other site 36809012660 ATP binding site [chemical binding]; other site 36809012661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 36809012662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 36809012663 active site 36809012664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012666 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 36809012667 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 36809012668 classical (c) SDRs; Region: SDR_c; cd05233 36809012669 NAD(P) binding site [chemical binding]; other site 36809012670 active site 36809012671 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809012672 PknH-like extracellular domain; Region: PknH_C; pfam14032 36809012673 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 36809012674 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 36809012675 E3 interaction surface; other site 36809012676 lipoyl attachment site [posttranslational modification]; other site 36809012677 e3 binding domain; Region: E3_binding; pfam02817 36809012678 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 36809012679 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 36809012680 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 36809012681 alpha subunit interface [polypeptide binding]; other site 36809012682 TPP binding site [chemical binding]; other site 36809012683 heterodimer interface [polypeptide binding]; other site 36809012684 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 36809012685 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 36809012686 tetramer interface [polypeptide binding]; other site 36809012687 TPP-binding site [chemical binding]; other site 36809012688 heterodimer interface [polypeptide binding]; other site 36809012689 phosphorylation loop region [posttranslational modification] 36809012690 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 36809012691 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 36809012692 Trehalase; Region: Trehalase; cl17346 36809012693 Predicted membrane protein [Function unknown]; Region: COG2311 36809012694 Protein of unknown function (DUF418); Region: DUF418; pfam04235 36809012695 short chain dehydrogenase; Provisional; Region: PRK08219 36809012696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 36809012697 NAD(P) binding site [chemical binding]; other site 36809012698 active site 36809012699 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 36809012700 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 36809012701 active site 36809012702 HIGH motif; other site 36809012703 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 36809012704 KMSKS motif; other site 36809012705 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 36809012706 tRNA binding surface [nucleotide binding]; other site 36809012707 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 36809012708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 36809012709 Protein of unknown function (DUF445); Region: DUF445; pfam04286 36809012710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 36809012711 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 36809012712 hypothetical protein; Validated; Region: PRK00228 36809012713 H+ Antiporter protein; Region: 2A0121; TIGR00900 36809012714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 36809012715 putative substrate translocation pore; other site 36809012716 TIGR03084 family protein; Region: TIGR03084 36809012717 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 36809012718 Wyosine base formation; Region: Wyosine_form; pfam08608 36809012719 acyltransferase PapA5; Provisional; Region: PRK09294 36809012720 hypothetical protein; Provisional; Region: PRK10621 36809012721 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 36809012722 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 36809012723 active site 36809012724 NTP binding site [chemical binding]; other site 36809012725 metal binding triad [ion binding]; metal-binding site 36809012726 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 36809012727 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 36809012728 Zn2+ binding site [ion binding]; other site 36809012729 Mg2+ binding site [ion binding]; other site 36809012730 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 36809012731 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 36809012732 active site 36809012733 Ap6A binding site [chemical binding]; other site 36809012734 nudix motif; other site 36809012735 metal binding site [ion binding]; metal-binding site 36809012736 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 36809012737 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 36809012738 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 36809012739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 36809012740 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 36809012741 DNA binding residues [nucleotide binding] 36809012742 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 36809012743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 36809012744 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 36809012745 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 36809012746 catalytic residues [active] 36809012747 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 36809012748 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 36809012749 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 36809012750 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 36809012751 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 36809012752 active site 36809012753 metal binding site [ion binding]; metal-binding site 36809012754 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 36809012755 Cytochrome P450; Region: p450; pfam00067 36809012756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 36809012757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 36809012758 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 36809012759 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 36809012760 ParB-like nuclease domain; Region: ParBc; pfam02195 36809012761 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 36809012762 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 36809012763 P-loop; other site 36809012764 Magnesium ion binding site [ion binding]; other site 36809012765 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 36809012766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 36809012767 S-adenosylmethionine binding site [chemical binding]; other site 36809012768 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 36809012769 G-X-X-G motif; other site 36809012770 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 36809012771 RxxxH motif; other site 36809012772 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 36809012773 Ribonuclease P; Region: Ribonuclease_P; cl00457 36809012774 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399