-- dump date   	20120504_152720
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
561007000001	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
561007000002	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
561007000003	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
561007000004	catalytic residues [active]
561007000005	catalytic nucleophile [active]
561007000006	Presynaptic Site I dimer interface [polypeptide binding]; other site
561007000007	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
561007000008	Synaptic Flat tetramer interface [polypeptide binding]; other site
561007000009	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007000010	dimerization interface [polypeptide binding]; other site
561007000011	putative DNA binding site [nucleotide binding]; other site
561007000012	putative Zn2+ binding site [ion binding]; other site
561007000013	mercuric reductase; Region: MerA; TIGR02053
561007000014	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007000015	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007000016	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
561007000017	alkylmercury lyase; Provisional; Region: PRK13239
561007000018	Alkylmercury lyase; Region: MerB; pfam03243
561007000019	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
561007000020	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007000021	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007000022	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
561007000023	catalytic residues [active]
561007000024	catalytic nucleophile [active]
561007000025	Presynaptic Site I dimer interface [polypeptide binding]; other site
561007000026	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
561007000027	Synaptic Flat tetramer interface [polypeptide binding]; other site
561007000028	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
561007000029	DNA-binding interface [nucleotide binding]; DNA binding site
561007000030	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
561007000031	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007000032	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
561007000033	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
561007000034	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007000035	P-loop; other site
561007000036	Magnesium ion binding site [ion binding]; other site
561007000037	Abi-like protein; Region: Abi_2; cl01988
561007000038	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
561007000039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007000040	Walker A motif; other site
561007000041	ATP binding site [chemical binding]; other site
561007000042	Walker B motif; other site
561007000043	arginine finger; other site
561007000044	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
561007000045	DnaA box-binding interface [nucleotide binding]; other site
561007000046	DNA polymerase III subunit beta; Validated; Region: PRK07761
561007000047	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
561007000048	putative DNA binding surface [nucleotide binding]; other site
561007000049	dimer interface [polypeptide binding]; other site
561007000050	beta-clamp/clamp loader binding surface; other site
561007000051	beta-clamp/translesion DNA polymerase binding surface; other site
561007000052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000053	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
561007000054	recombination protein F; Reviewed; Region: recF; PRK00064
561007000055	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
561007000056	Walker A/P-loop; other site
561007000057	ATP binding site [chemical binding]; other site
561007000058	Q-loop/lid; other site
561007000059	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007000060	ABC transporter signature motif; other site
561007000061	Walker B; other site
561007000062	D-loop; other site
561007000063	H-loop/switch region; other site
561007000064	Protein of unknown function (DUF721); Region: DUF721; cl02324
561007000065	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
561007000066	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007000067	ATP binding site [chemical binding]; other site
561007000068	Mg2+ binding site [ion binding]; other site
561007000069	G-X-G motif; other site
561007000070	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
561007000071	anchoring element; other site
561007000072	dimer interface [polypeptide binding]; other site
561007000073	ATP binding site [chemical binding]; other site
561007000074	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
561007000075	active site
561007000076	putative metal-binding site [ion binding]; other site
561007000077	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
561007000078	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007000079	N-acetyltransferase; Region: Acetyltransf_2; cl00949
561007000080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
561007000081	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
561007000082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007000083	S-adenosylmethionine binding site [chemical binding]; other site
561007000084	DNA gyrase subunit A; Validated; Region: PRK05560
561007000085	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
561007000086	CAP-like domain; other site
561007000087	active site
561007000088	primary dimer interface [polypeptide binding]; other site
561007000089	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
561007000090	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
561007000091	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
561007000092	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
561007000093	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
561007000094	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
561007000095	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
561007000096	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
561007000097	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
561007000098	Helix-turn-helix domains; Region: HTH; cl00088
561007000099	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007000100	dimerization interface [polypeptide binding]; other site
561007000101	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
561007000102	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
561007000103	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
561007000104	active site
561007000105	Rhomboid family; Region: Rhomboid; cl11446
561007000106	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007000107	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
561007000108	Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506
561007000109	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
561007000110	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
561007000111	Glutamine amidotransferase class-I; Region: GATase; pfam00117
561007000112	glutamine binding [chemical binding]; other site
561007000113	catalytic triad [active]
561007000114	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007000115	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
561007000116	active site
561007000117	ATP binding site [chemical binding]; other site
561007000118	substrate binding site [chemical binding]; other site
561007000119	activation loop (A-loop); other site
561007000120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
561007000121	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
561007000122	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
561007000123	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
561007000124	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
561007000125	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007000126	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
561007000127	active site
561007000128	ATP binding site [chemical binding]; other site
561007000129	substrate binding site [chemical binding]; other site
561007000130	activation loop (A-loop); other site
561007000131	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007000132	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
561007000133	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
561007000134	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
561007000135	active site
561007000136	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
561007000137	phosphopeptide binding site; other site
561007000138	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
561007000139	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
561007000140	phosphopeptide binding site; other site
561007000141	Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503
561007000142	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
561007000143	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
561007000144	Helix-turn-helix domains; Region: HTH; cl00088
561007000145	PPE family; Region: PPE; pfam00823
561007000146	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007000147	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007000148	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007000149	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
561007000150	nucleoside/Zn binding site; other site
561007000151	dimer interface [polypeptide binding]; other site
561007000152	catalytic motif [active]
561007000153	cyanate hydratase; Validated; Region: PRK02866
561007000154	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
561007000155	oligomer interface [polypeptide binding]; other site
561007000156	active site
561007000157	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
561007000158	Helix-turn-helix domains; Region: HTH; cl00088
561007000159	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
561007000160	dimerization interface [polypeptide binding]; other site
561007000161	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
561007000162	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007000163	ATP binding site [chemical binding]; other site
561007000164	putative Mg++ binding site [ion binding]; other site
561007000165	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007000166	Helicase associated domain (HA2); Region: HA2; cl04503
561007000167	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
561007000168	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
561007000169	short chain dehydrogenase; Provisional; Region: PRK07041
561007000170	classical (c) SDRs; Region: SDR_c; cd05233
561007000171	NAD(P) binding site [chemical binding]; other site
561007000172	active site
561007000173	AAA domain; Region: AAA_31; pfam13614
561007000174	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
561007000175	P loop; other site
561007000176	Nucleotide binding site [chemical binding]; other site
561007000177	DTAP/Switch II; other site
561007000178	Switch I; other site
561007000179	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
561007000180	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007000181	active site
561007000182	phosphorylation site [posttranslational modification]
561007000183	intermolecular recognition site; other site
561007000184	dimerization interface [polypeptide binding]; other site
561007000185	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007000186	DNA binding residues [nucleotide binding]
561007000187	dimerization interface [polypeptide binding]; other site
561007000188	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
561007000189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007000190	ATP binding site [chemical binding]; other site
561007000191	Mg2+ binding site [ion binding]; other site
561007000192	G-X-G motif; other site
561007000193	mycothione reductase; Reviewed; Region: PRK07846
561007000194	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007000195	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007000196	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
561007000197	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007000198	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007000199	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007000200	active site
561007000201	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007000202	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007000203	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
561007000204	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007000205	DNA-binding site [nucleotide binding]; DNA binding site
561007000206	FCD domain; Region: FCD; cl11656
561007000207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007000208	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
561007000209	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
561007000210	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
561007000211	active site residue [active]
561007000212	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
561007000213	active site residue [active]
561007000214	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
561007000215	classical (c) SDRs; Region: SDR_c; cd05233
561007000216	NAD(P) binding site [chemical binding]; other site
561007000217	active site
561007000218	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
561007000219	classical (c) SDRs; Region: SDR_c; cd05233
561007000220	NAD(P) binding site [chemical binding]; other site
561007000221	active site
561007000222	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007000223	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000224	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007000225	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007000226	active site
561007000227	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
561007000228	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
561007000229	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
561007000230	active site
561007000231	Fe binding site [ion binding]; other site
561007000232	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007000233	Helix-turn-helix domains; Region: HTH; cl00088
561007000234	Bacterial transcriptional regulator; Region: IclR; pfam01614
561007000235	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000236	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007000237	substrate binding pocket [chemical binding]; other site
561007000238	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000239	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
561007000240	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
561007000241	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845
561007000242	Helix-turn-helix domains; Region: HTH; cl00088
561007000243	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007000244	Helix-turn-helix domains; Region: HTH; cl00088
561007000245	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
561007000246	Uncharacterized conserved protein [Function unknown]; Region: COG5361
561007000247	transcriptional regulator BetI; Validated; Region: PRK00767
561007000248	Helix-turn-helix domains; Region: HTH; cl00088
561007000249	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
561007000250	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
561007000251	alkaline phosphatase; Provisional; Region: PRK10518
561007000252	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
561007000253	active site
561007000254	dimer interface [polypeptide binding]; other site
561007000255	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
561007000256	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
561007000257	FMN-binding pocket [chemical binding]; other site
561007000258	flavin binding motif; other site
561007000259	phosphate binding motif [ion binding]; other site
561007000260	beta-alpha-beta structure motif; other site
561007000261	NAD binding pocket [chemical binding]; other site
561007000262	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007000263	catalytic loop [active]
561007000264	iron binding site [ion binding]; other site
561007000265	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007000266	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007000267	short chain dehydrogenase; Provisional; Region: PRK05650
561007000268	classical (c) SDRs; Region: SDR_c; cd05233
561007000269	NAD(P) binding site [chemical binding]; other site
561007000270	active site
561007000271	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
561007000272	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
561007000273	active site
561007000274	dimer interface [polypeptide binding]; other site
561007000275	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
561007000276	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
561007000277	active site
561007000278	FMN binding site [chemical binding]; other site
561007000279	substrate binding site [chemical binding]; other site
561007000280	3Fe-4S cluster binding site [ion binding]; other site
561007000281	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
561007000282	domain interface; other site
561007000283	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
561007000284	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000285	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
561007000286	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
561007000287	active site
561007000288	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007000289	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
561007000290	hypothetical protein; Provisional; Region: PRK07945
561007000291	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
561007000292	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007000293	Helix-turn-helix domains; Region: HTH; cl00088
561007000294	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007000295	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000296	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
561007000297	classical (c) SDRs; Region: SDR_c; cd05233
561007000298	NAD(P) binding site [chemical binding]; other site
561007000299	active site
561007000300	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007000301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007000302	S-adenosylmethionine binding site [chemical binding]; other site
561007000303	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007000304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000305	enoyl-CoA hydratase; Provisional; Region: PRK08260
561007000306	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007000307	substrate binding site [chemical binding]; other site
561007000308	oxyanion hole (OAH) forming residues; other site
561007000309	trimer interface [polypeptide binding]; other site
561007000310	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
561007000311	FAD binding domain; Region: FAD_binding_4; pfam01565
561007000312	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
561007000313	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
561007000314	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
561007000315	dimer interface [polypeptide binding]; other site
561007000316	active site
561007000317	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
561007000318	substrate binding site [chemical binding]; other site
561007000319	catalytic residue [active]
561007000320	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
561007000321	Bacterial Ig-like domain; Region: Big_5; cl01012
561007000322	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
561007000323	Domain of unknown function (DUF955); Region: DUF955; cl01076
561007000324	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
561007000325	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
561007000326	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
561007000327	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
561007000328	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
561007000329	active site residue [active]
561007000330	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
561007000331	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
561007000332	putative active site [active]
561007000333	catalytic site [active]
561007000334	putative metal binding site [ion binding]; other site
561007000335	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
561007000336	metal binding site [ion binding]; metal-binding site
561007000337	active site
561007000338	I-site; other site
561007000339	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007000340	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
561007000341	Ferritin-like domain; Region: Ferritin; pfam00210
561007000342	ferroxidase diiron center [ion binding]; other site
561007000343	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
561007000344	Ferritin-like domain; Region: Ferritin; pfam00210
561007000345	ferroxidase diiron center [ion binding]; other site
561007000346	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
561007000347	CAAX protease self-immunity; Region: Abi; cl00558
561007000348	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007000349	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
561007000350	prephenate dehydratase; Provisional; Region: PRK11898
561007000351	Prephenate dehydratase; Region: PDT; pfam00800
561007000352	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
561007000353	putative L-Phe binding site [chemical binding]; other site
561007000354	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007000355	catalytic core [active]
561007000356	pyruvate dehydrogenase; Provisional; Region: PRK09124
561007000357	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
561007000358	PYR/PP interface [polypeptide binding]; other site
561007000359	dimer interface [polypeptide binding]; other site
561007000360	tetramer interface [polypeptide binding]; other site
561007000361	TPP binding site [chemical binding]; other site
561007000362	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
561007000363	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
561007000364	TPP-binding site [chemical binding]; other site
561007000365	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007000366	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007000367	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
561007000368	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007000369	Helix-turn-helix domains; Region: HTH; cl00088
561007000370	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000371	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007000372	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007000373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000374	NAD(P) binding pocket [chemical binding]; other site
561007000375	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007000376	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007000377	short chain dehydrogenase; Provisional; Region: PRK08251
561007000378	classical (c) SDRs; Region: SDR_c; cd05233
561007000379	NAD(P) binding site [chemical binding]; other site
561007000380	active site
561007000381	short chain dehydrogenase; Provisional; Region: PRK07832
561007000382	classical (c) SDRs; Region: SDR_c; cd05233
561007000383	NAD(P) binding site [chemical binding]; other site
561007000384	active site
561007000385	Helix-turn-helix domains; Region: HTH; cl00088
561007000386	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007000387	MgtC family; Region: MgtC; pfam02308
561007000388	EspG family; Region: ESX-1_EspG; pfam14011
561007000389	PPE family; Region: PPE; pfam00823
561007000390	Possibl zinc metallo-peptidase; Region: DUF1025; cl01577
561007000391	Septum formation; Region: Septum_form; pfam13845
561007000392	Septum formation; Region: Septum_form; pfam13845
561007000393	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
561007000394	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
561007000395	seryl-tRNA synthetase; Provisional; Region: PRK05431
561007000396	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
561007000397	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
561007000398	dimer interface [polypeptide binding]; other site
561007000399	active site
561007000400	motif 1; other site
561007000401	motif 2; other site
561007000402	motif 3; other site
561007000403	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007000404	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007000405	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
561007000406	Helix-turn-helix domains; Region: HTH; cl00088
561007000407	Helix-turn-helix domains; Region: HTH; cl00088
561007000408	Predicted ATPase [General function prediction only]; Region: COG3910
561007000409	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007000410	Walker A/P-loop; other site
561007000411	ATP binding site [chemical binding]; other site
561007000412	Q-loop/lid; other site
561007000413	ABC transporter signature motif; other site
561007000414	Walker B; other site
561007000415	D-loop; other site
561007000416	H-loop/switch region; other site
561007000417	Nitronate monooxygenase; Region: NMO; pfam03060
561007000418	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
561007000419	FMN binding site [chemical binding]; other site
561007000420	substrate binding site [chemical binding]; other site
561007000421	putative catalytic residue [active]
561007000422	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
561007000423	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007000424	Helix-turn-helix domains; Region: HTH; cl00088
561007000425	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
561007000426	putative dimerization interface [polypeptide binding]; other site
561007000427	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
561007000428	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150
561007000429	active site
561007000430	ATP binding site [chemical binding]; other site
561007000431	Phosphotransferase enzyme family; Region: APH; pfam01636
561007000432	antibiotic binding site [chemical binding]; other site
561007000433	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
561007000434	classical (c) SDRs; Region: SDR_c; cd05233
561007000435	NAD(P) binding site [chemical binding]; other site
561007000436	active site
561007000437	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
561007000438	putative acyl-acceptor binding pocket; other site
561007000439	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
561007000440	putative acyl-acceptor binding pocket; other site
561007000441	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007000442	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
561007000443	active site
561007000444	motif I; other site
561007000445	motif II; other site
561007000446	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007000447	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
561007000448	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
561007000449	amidase catalytic site [active]
561007000450	Zn binding residues [ion binding]; other site
561007000451	substrate binding site [chemical binding]; other site
561007000452	LGFP repeat; Region: LGFP; pfam08310
561007000453	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
561007000454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000455	UDP-galactopyranose mutase; Region: GLF; pfam03275
561007000456	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
561007000457	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
561007000458	active site
561007000459	UbiA prenyltransferase family; Region: UbiA; cl00337
561007000460	Predicted esterase [General function prediction only]; Region: COG0627
561007000461	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000462	Predicted esterase [General function prediction only]; Region: COG0627
561007000463	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000464	Predicted esterase [General function prediction only]; Region: COG0627
561007000465	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000466	Cutinase; Region: Cutinase; pfam01083
561007000467	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
561007000468	AMP-binding enzyme; Region: AMP-binding; cl15778
561007000469	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007000470	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007000471	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
561007000472	active site
561007000473	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
561007000474	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007000475	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007000476	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
561007000477	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
561007000478	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
561007000479	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007000480	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007000481	Cation efflux family; Region: Cation_efflux; cl00316
561007000482	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
561007000483	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
561007000484	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
561007000485	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007000486	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
561007000487	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
561007000488	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
561007000489	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
561007000490	classical (c) SDRs; Region: SDR_c; cd05233
561007000491	NAD(P) binding site [chemical binding]; other site
561007000492	active site
561007000493	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
561007000494	FAD binding domain; Region: FAD_binding_4; pfam01565
561007000495	D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370
561007000496	GtrA-like protein; Region: GtrA; cl00971
561007000497	dihydroxyacetone kinase; Provisional; Region: PRK14479
561007000498	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
561007000499	DAK2 domain; Region: Dak2; cl03685
561007000500	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007000501	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007000502	DNA-binding site [nucleotide binding]; DNA binding site
561007000503	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007000504	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007000505	homodimer interface [polypeptide binding]; other site
561007000506	catalytic residue [active]
561007000507	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007000508	Uncharacterized conserved protein [Function unknown]; Region: COG2128
561007000509	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
561007000510	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
561007000511	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
561007000512	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
561007000513	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
561007000514	active site
561007000515	ABC-2 type transporter; Region: ABC2_membrane; cl11417
561007000516	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
561007000517	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
561007000518	active site
561007000519	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
561007000520	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
561007000521	Walker A/P-loop; other site
561007000522	ATP binding site [chemical binding]; other site
561007000523	Q-loop/lid; other site
561007000524	ABC transporter signature motif; other site
561007000525	Walker B; other site
561007000526	D-loop; other site
561007000527	H-loop/switch region; other site
561007000528	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
561007000529	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
561007000530	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007000531	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007000532	catalytic residue [active]
561007000533	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
561007000534	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
561007000535	NAD(P) binding site [chemical binding]; other site
561007000536	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007000537	Helix-turn-helix domains; Region: HTH; cl00088
561007000538	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
561007000539	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007000540	OsmC-like protein; Region: OsmC; cl00767
561007000541	Predicted transcriptional regulator [Transcription]; Region: COG2345
561007000542	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
561007000543	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
561007000544	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
561007000545	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007000546	catalytic residue [active]
561007000547	TQXA domain; Region: TQXA_dom; TIGR03934
561007000548	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
561007000549	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007000550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007000551	homodimer interface [polypeptide binding]; other site
561007000552	catalytic residue [active]
561007000553	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007000554	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
561007000555	active site
561007000556	DNA binding site [nucleotide binding]
561007000557	Int/Topo IB signature motif; other site
561007000558	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007000559	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
561007000560	Phage-related protein [Function unknown]; Region: COG5412
561007000561	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
561007000562	active site
561007000563	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
561007000564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007000565	S-adenosylmethionine binding site [chemical binding]; other site
561007000566	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
561007000567	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
561007000568	putative hydrophobic ligand binding site [chemical binding]; other site
561007000569	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
561007000570	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
561007000571	choline dehydrogenase; Validated; Region: PRK02106
561007000572	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
561007000573	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
561007000574	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007000575	catalytic core [active]
561007000576	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007000577	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007000578	active site
561007000579	Uncharacterized conserved protein [Function unknown]; Region: COG2966
561007000580	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
561007000581	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
561007000582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000583	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
561007000584	classical (c) SDRs; Region: SDR_c; cd05233
561007000585	NAD(P) binding site [chemical binding]; other site
561007000586	active site
561007000587	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007000588	Helix-turn-helix domains; Region: HTH; cl00088
561007000589	NMT1-like family; Region: NMT1_2; cl15260
561007000590	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
561007000591	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
561007000592	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
561007000593	Walker A/P-loop; other site
561007000594	ATP binding site [chemical binding]; other site
561007000595	Q-loop/lid; other site
561007000596	ABC transporter signature motif; other site
561007000597	Walker B; other site
561007000598	D-loop; other site
561007000599	H-loop/switch region; other site
561007000600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007000601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007000602	Putative glycolipid-binding; Region: Glycolipid_bind; cl01425
561007000603	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000604	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
561007000605	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
561007000606	nucleoside/Zn binding site; other site
561007000607	dimer interface [polypeptide binding]; other site
561007000608	catalytic motif [active]
561007000609	GXWXG protein; Region: GXWXG; pfam14231
561007000610	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
561007000611	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
561007000612	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
561007000613	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007000614	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
561007000615	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
561007000616	substrate binding pocket [chemical binding]; other site
561007000617	membrane-bound complex binding site; other site
561007000618	hinge residues; other site
561007000619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007000620	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
561007000621	dimer interface [polypeptide binding]; other site
561007000622	conserved gate region; other site
561007000623	putative PBP binding loops; other site
561007000624	ABC-ATPase subunit interface; other site
561007000625	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
561007000626	active site
561007000627	HIGH motif; other site
561007000628	nucleotide binding site [chemical binding]; other site
561007000629	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
561007000630	active site
561007000631	KMSKS motif; other site
561007000632	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
561007000633	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
561007000634	active site
561007000635	DNA binding site [nucleotide binding]
561007000636	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
561007000637	DNA binding site [nucleotide binding]
561007000638	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
561007000639	nucleotide binding site [chemical binding]; other site
561007000640	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
561007000641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007000642	putative substrate translocation pore; other site
561007000643	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007000644	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
561007000645	NAD(P) binding site [chemical binding]; other site
561007000646	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
561007000647	hydrophobic ligand binding site; other site
561007000648	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
561007000649	AMP-binding enzyme; Region: AMP-binding; cl15778
561007000650	salicylate hydroxylase; Provisional; Region: PRK08163
561007000651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000652	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000653	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
561007000654	tetramer interface [polypeptide binding]; other site
561007000655	active site
561007000656	GAF domain; Region: GAF_2; pfam13185
561007000657	GAF domain; Region: GAF; cl15785
561007000658	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
561007000659	Helix-turn-helix domains; Region: HTH; cl00088
561007000660	DDE superfamily endonuclease; Region: DDE_5; cl02413
561007000661	Carboxylesterase family; Region: COesterase; pfam00135
561007000662	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000663	substrate binding pocket [chemical binding]; other site
561007000664	catalytic triad [active]
561007000665	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
561007000666	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
561007000667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000668	NAD(P) binding site [chemical binding]; other site
561007000669	active site
561007000670	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
561007000671	Isochorismatase family; Region: Isochorismatase; pfam00857
561007000672	catalytic triad [active]
561007000673	conserved cis-peptide bond; other site
561007000674	isochorismate synthase DhbC; Validated; Region: PRK06923
561007000675	chorismate binding enzyme; Region: Chorismate_bind; cl10555
561007000676	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
561007000677	Glutamine amidotransferase class-I; Region: GATase; pfam00117
561007000678	glutamine binding [chemical binding]; other site
561007000679	catalytic triad [active]
561007000680	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007000681	Helix-turn-helix domains; Region: HTH; cl00088
561007000682	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000683	substrate binding pocket [chemical binding]; other site
561007000684	catalytic triad [active]
561007000685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000687	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007000688	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
561007000689	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007000690	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007000691	catalytic residue [active]
561007000692	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
561007000693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007000694	Walker A motif; other site
561007000695	ATP binding site [chemical binding]; other site
561007000696	Walker B motif; other site
561007000697	arginine finger; other site
561007000698	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
561007000699	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
561007000700	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
561007000701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007000702	S-adenosylmethionine binding site [chemical binding]; other site
561007000703	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
561007000704	FAD binding domain; Region: FAD_binding_4; pfam01565
561007000705	enolase; Provisional; Region: eno; PRK00077
561007000706	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
561007000707	dimer interface [polypeptide binding]; other site
561007000708	metal binding site [ion binding]; metal-binding site
561007000709	substrate binding pocket [chemical binding]; other site
561007000710	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007000711	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
561007000712	substrate binding site [chemical binding]; other site
561007000713	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007000714	Helix-turn-helix domains; Region: HTH; cl00088
561007000715	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007000716	active site
561007000717	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
561007000718	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007000719	substrate binding site [chemical binding]; other site
561007000720	oxyanion hole (OAH) forming residues; other site
561007000721	trimer interface [polypeptide binding]; other site
561007000722	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007000723	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
561007000724	active site
561007000725	metal binding site [ion binding]; metal-binding site
561007000726	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
561007000727	recombination protein RecR; Reviewed; Region: recR; PRK00076
561007000728	RecR protein; Region: RecR; pfam02132
561007000729	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
561007000730	putative active site [active]
561007000731	putative metal-binding site [ion binding]; other site
561007000732	tetramer interface [polypeptide binding]; other site
561007000733	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
561007000734	catalytic triad [active]
561007000735	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
561007000736	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
561007000737	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007000738	Helix-turn-helix domains; Region: HTH; cl00088
561007000739	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
561007000740	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
561007000741	putative active site [active]
561007000742	putative substrate binding site [chemical binding]; other site
561007000743	ATP binding site [chemical binding]; other site
561007000744	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007000745	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007000746	active site
561007000747	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
561007000748	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
561007000749	active site
561007000750	catalytic site [active]
561007000751	substrate binding site [chemical binding]; other site
561007000752	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007000753	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
561007000754	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
561007000755	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
561007000756	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
561007000757	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
561007000758	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007000759	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
561007000760	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
561007000761	2-isopropylmalate synthase; Validated; Region: PRK03739
561007000762	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
561007000763	active site
561007000764	catalytic residues [active]
561007000765	metal binding site [ion binding]; metal-binding site
561007000766	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
561007000767	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007000768	Helix-turn-helix domains; Region: HTH; cl00088
561007000769	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
561007000770	FMN binding site [chemical binding]; other site
561007000771	dimer interface [polypeptide binding]; other site
561007000772	aspartate kinase; Reviewed; Region: PRK06635
561007000773	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
561007000774	putative nucleotide binding site [chemical binding]; other site
561007000775	putative catalytic residues [active]
561007000776	putative Mg ion binding site [ion binding]; other site
561007000777	putative aspartate binding site [chemical binding]; other site
561007000778	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
561007000779	putative allosteric regulatory site; other site
561007000780	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
561007000781	putative allosteric regulatory residue; other site
561007000782	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
561007000783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000784	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
561007000785	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
561007000786	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
561007000787	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007000788	ATP binding site [chemical binding]; other site
561007000789	Walker B motif; other site
561007000790	arginine finger; other site
561007000791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
561007000792	TPR motif; other site
561007000793	binding surface
561007000794	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
561007000795	TPR motif; other site
561007000796	TPR repeat; Region: TPR_11; pfam13414
561007000797	binding surface
561007000798	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007000799	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000800	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000801	Protein of unknown function, DUF486; Region: DUF486; cl01236
561007000802	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
561007000803	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
561007000804	tetramer interface [polypeptide binding]; other site
561007000805	heme binding pocket [chemical binding]; other site
561007000806	NADPH binding site [chemical binding]; other site
561007000807	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007000808	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007000809	Nitronate monooxygenase; Region: NMO; pfam03060
561007000810	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
561007000811	FMN binding site [chemical binding]; other site
561007000812	substrate binding site [chemical binding]; other site
561007000813	putative catalytic residue [active]
561007000814	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
561007000815	Phospholipid methyltransferase; Region: PEMT; cl00763
561007000816	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
561007000817	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007000818	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
561007000819	putative substrate binding site [chemical binding]; other site
561007000820	putative ATP binding site [chemical binding]; other site
561007000821	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007000822	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007000823	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
561007000824	active site
561007000825	dimer interface [polypeptide binding]; other site
561007000826	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
561007000827	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
561007000828	dimer interface [polypeptide binding]; other site
561007000829	active site
561007000830	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
561007000831	dimer interface [polypeptide binding]; other site
561007000832	active site
561007000833	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
561007000834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007000835	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
561007000836	putative substrate translocation pore; other site
561007000837	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007000838	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007000839	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
561007000840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000841	NAD(P) binding site [chemical binding]; other site
561007000842	active site
561007000843	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
561007000844	TIGR03440 family protein; Region: unchr_TIGR03440
561007000845	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
561007000846	TIGR03442 family protein; Region: TIGR03442
561007000847	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
561007000848	putative active site [active]
561007000849	putative dimer interface [polypeptide binding]; other site
561007000850	probable methyltransferase; Region: TIGR03438
561007000851	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
561007000852	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
561007000853	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007000854	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007000855	catalytic residue [active]
561007000856	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
561007000857	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007000858	Helix-turn-helix domains; Region: HTH; cl00088
561007000859	lipid-transfer protein; Provisional; Region: PRK08256
561007000860	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007000861	active site
561007000862	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
561007000863	active site
561007000864	catalytic site [active]
561007000865	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007000866	active site 2 [active]
561007000867	active site 1 [active]
561007000868	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007000869	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
561007000870	NAD(P) binding site [chemical binding]; other site
561007000871	active site
561007000872	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
561007000873	amphipathic channel; other site
561007000874	Asn-Pro-Ala signature motifs; other site
561007000875	glycerol kinase; Provisional; Region: glpK; PRK00047
561007000876	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
561007000877	N- and C-terminal domain interface [polypeptide binding]; other site
561007000878	putative active site [active]
561007000879	putative MgATP binding site [chemical binding]; other site
561007000880	catalytic site [active]
561007000881	metal binding site [ion binding]; metal-binding site
561007000882	putative homotetramer interface [polypeptide binding]; other site
561007000883	putative glycerol binding site [chemical binding]; other site
561007000884	homodimer interface [polypeptide binding]; other site
561007000885	Helix-turn-helix domains; Region: HTH; cl00088
561007000886	putative DNA binding helix; other site
561007000887	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
561007000888	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
561007000889	RDD family; Region: RDD; cl00746
561007000890	Integral membrane protein DUF95; Region: DUF95; cl00572
561007000891	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
561007000892	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007000893	MoxR-like ATPases [General function prediction only]; Region: COG0714
561007000894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007000895	Walker A motif; other site
561007000896	ATP binding site [chemical binding]; other site
561007000897	Walker B motif; other site
561007000898	arginine finger; other site
561007000899	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
561007000900	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
561007000901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007000902	S-adenosylmethionine binding site [chemical binding]; other site
561007000903	Domain of unknown function (DUF222); Region: DUF222; pfam02720
561007000904	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
561007000905	active site
561007000906	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
561007000907	minor groove reading motif; other site
561007000908	helix-hairpin-helix signature motif; other site
561007000909	active site
561007000910	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
561007000911	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
561007000912	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
561007000913	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007000914	Family description; Region: UvrD_C_2; cl15862
561007000915	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
561007000916	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
561007000917	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
561007000918	OpgC protein; Region: OpgC_C; cl00792
561007000919	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
561007000920	active site
561007000921	catalytic triad [active]
561007000922	oxyanion hole [active]
561007000923	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007000924	Coenzyme A binding pocket [chemical binding]; other site
561007000925	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
561007000926	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
561007000927	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007000928	catalytic residue [active]
561007000929	Predicted phosphohydrolases [General function prediction only]; Region: COG1408
561007000930	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
561007000931	putative active site [active]
561007000932	putative metal binding site [ion binding]; other site
561007000933	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
561007000934	Transglycosylase; Region: Transgly; cl07896
561007000935	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007000936	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
561007000937	Transcription factor WhiB; Region: Whib; pfam02467
561007000938	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
561007000939	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
561007000940	DTAP/Switch II; other site
561007000941	Switch I; other site
561007000942	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
561007000943	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
561007000944	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
561007000945	P loop; other site
561007000946	Nucleotide binding site [chemical binding]; other site
561007000947	DTAP/Switch II; other site
561007000948	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
561007000949	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
561007000950	homotrimer interaction site [polypeptide binding]; other site
561007000951	putative active site [active]
561007000952	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007000953	EamA-like transporter family; Region: EamA; cl01037
561007000954	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
561007000955	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
561007000956	ligand binding site [chemical binding]; other site
561007000957	flexible hinge region; other site
561007000958	Helix-turn-helix domains; Region: HTH; cl00088
561007000959	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
561007000960	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
561007000961	minor groove reading motif; other site
561007000962	helix-hairpin-helix signature motif; other site
561007000963	substrate binding pocket [chemical binding]; other site
561007000964	active site
561007000965	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
561007000966	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
561007000967	catalytic residues [active]
561007000968	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
561007000969	putative active site [active]
561007000970	putative CoA binding site [chemical binding]; other site
561007000971	nudix motif; other site
561007000972	metal binding site [ion binding]; metal-binding site
561007000973	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
561007000974	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007000975	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007000976	Protein of unknown function (DUF1469); Region: DUF1469; cl12095
561007000977	acetyl-CoA synthetase; Provisional; Region: PRK00174
561007000978	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
561007000979	AMP-binding enzyme; Region: AMP-binding; cl15778
561007000980	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007000981	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
561007000982	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
561007000983	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
561007000984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007000985	dimer interface [polypeptide binding]; other site
561007000986	conserved gate region; other site
561007000987	putative PBP binding loops; other site
561007000988	ABC-ATPase subunit interface; other site
561007000989	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
561007000990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007000991	dimer interface [polypeptide binding]; other site
561007000992	conserved gate region; other site
561007000993	putative PBP binding loops; other site
561007000994	ABC-ATPase subunit interface; other site
561007000995	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
561007000996	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
561007000997	Walker A/P-loop; other site
561007000998	ATP binding site [chemical binding]; other site
561007000999	Q-loop/lid; other site
561007001000	ABC transporter signature motif; other site
561007001001	Walker B; other site
561007001002	D-loop; other site
561007001003	H-loop/switch region; other site
561007001004	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
561007001005	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
561007001006	Walker A/P-loop; other site
561007001007	ATP binding site [chemical binding]; other site
561007001008	Q-loop/lid; other site
561007001009	ABC transporter signature motif; other site
561007001010	Walker B; other site
561007001011	D-loop; other site
561007001012	H-loop/switch region; other site
561007001013	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
561007001014	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007001015	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
561007001016	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
561007001017	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007001018	ATP binding site [chemical binding]; other site
561007001019	Walker B motif; other site
561007001020	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007001021	non-specific DNA binding site [nucleotide binding]; other site
561007001022	salt bridge; other site
561007001023	sequence-specific DNA binding site [nucleotide binding]; other site
561007001024	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
561007001025	Domain of unknown function (DUF955); Region: DUF955; cl01076
561007001026	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
561007001027	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
561007001028	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007001029	active site
561007001030	DNA binding site [nucleotide binding]
561007001031	Int/Topo IB signature motif; other site
561007001032	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007001033	active site
561007001034	Int/Topo IB signature motif; other site
561007001035	DNA binding site [nucleotide binding]
561007001036	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
561007001037	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
561007001038	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
561007001039	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007001040	motif II; other site
561007001041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007001042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007001043	putative substrate translocation pore; other site
561007001044	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
561007001045	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
561007001046	dimer interface [polypeptide binding]; other site
561007001047	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007001048	catalytic residue [active]
561007001049	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
561007001050	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
561007001051	NodB motif; other site
561007001052	active site
561007001053	catalytic site [active]
561007001054	metal binding site [ion binding]; metal-binding site
561007001055	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
561007001056	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
561007001057	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007001058	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007001059	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007001060	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
561007001061	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
561007001062	active site clefts [active]
561007001063	zinc binding site [ion binding]; other site
561007001064	dimer interface [polypeptide binding]; other site
561007001065	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007001066	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
561007001067	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
561007001068	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001069	Helix-turn-helix domains; Region: HTH; cl00088
561007001070	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007001071	Transport protein; Region: actII; TIGR00833
561007001072	Helix-turn-helix domains; Region: HTH; cl00088
561007001073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001074	NmrA-like family; Region: NmrA; pfam05368
561007001075	NAD(P) binding site [chemical binding]; other site
561007001076	active site
561007001077	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
561007001078	active site
561007001079	catalytic triad [active]
561007001080	dimer interface [polypeptide binding]; other site
561007001081	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001082	Helix-turn-helix domains; Region: HTH; cl00088
561007001083	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001084	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007001085	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
561007001086	active site
561007001087	FMN binding site [chemical binding]; other site
561007001088	substrate binding site [chemical binding]; other site
561007001089	homotetramer interface [polypeptide binding]; other site
561007001090	catalytic residue [active]
561007001091	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
561007001092	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007001093	ATP binding site [chemical binding]; other site
561007001094	putative Mg++ binding site [ion binding]; other site
561007001095	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
561007001096	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
561007001097	DNA-binding site [nucleotide binding]; DNA binding site
561007001098	RNA-binding motif; other site
561007001099	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
561007001100	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
561007001101	active site
561007001102	interdomain interaction site; other site
561007001103	putative metal-binding site [ion binding]; other site
561007001104	nucleotide binding site [chemical binding]; other site
561007001105	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
561007001106	domain I; other site
561007001107	phosphate binding site [ion binding]; other site
561007001108	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
561007001109	domain II; other site
561007001110	domain III; other site
561007001111	nucleotide binding site [chemical binding]; other site
561007001112	DNA binding groove [nucleotide binding]
561007001113	catalytic site [active]
561007001114	domain IV; other site
561007001115	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
561007001116	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
561007001117	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
561007001118	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
561007001119	dimerization interface [polypeptide binding]; other site
561007001120	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
561007001121	cyclase homology domain; Region: CHD; cd07302
561007001122	nucleotidyl binding site; other site
561007001123	metal binding site [ion binding]; metal-binding site
561007001124	dimer interface [polypeptide binding]; other site
561007001125	DNA polymerase III subunit delta'; Validated; Region: PRK07940
561007001126	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007001127	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007001128	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007001129	CAAX protease self-immunity; Region: Abi; cl00558
561007001130	Helix-turn-helix domains; Region: HTH; cl00088
561007001131	WHG domain; Region: WHG; pfam13305
561007001132	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
561007001133	Predicted acyl esterases [General function prediction only]; Region: COG2936
561007001134	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
561007001135	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
561007001136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001137	NAD(P) binding site [chemical binding]; other site
561007001138	active site
561007001139	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
561007001140	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
561007001141	Ligand binding site; other site
561007001142	Putative Catalytic site; other site
561007001143	DXD motif; other site
561007001144	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
561007001145	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
561007001146	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
561007001147	Zn binding site [ion binding]; other site
561007001148	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
561007001149	AMP-binding enzyme; Region: AMP-binding; cl15778
561007001150	AMP-binding enzyme; Region: AMP-binding; cl15778
561007001151	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007001152	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
561007001153	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
561007001154	putative trimer interface [polypeptide binding]; other site
561007001155	putative CoA binding site [chemical binding]; other site
561007001156	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
561007001157	putative trimer interface [polypeptide binding]; other site
561007001158	putative CoA binding site [chemical binding]; other site
561007001159	Integral membrane protein TerC family; Region: TerC; cl10468
561007001160	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
561007001161	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007001162	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007001163	catalytic residue [active]
561007001164	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007001165	classical (c) SDRs; Region: SDR_c; cd05233
561007001166	NAD(P) binding site [chemical binding]; other site
561007001167	active site
561007001168	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
561007001169	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007001170	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
561007001171	dimer interface [polypeptide binding]; other site
561007001172	substrate binding site [chemical binding]; other site
561007001173	metal binding sites [ion binding]; metal-binding site
561007001174	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007001175	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
561007001176	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007001177	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
561007001178	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
561007001179	TilS substrate binding domain; Region: TilS; pfam09179
561007001180	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007001181	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001182	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007001183	active site
561007001184	Protein of unknown function (DUF541); Region: SIMPL; cl01077
561007001185	Protein of unknown function (DUF541); Region: SIMPL; cl01077
561007001186	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
561007001187	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
561007001188	putative NAD(P) binding site [chemical binding]; other site
561007001189	catalytic Zn binding site [ion binding]; other site
561007001190	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007001191	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
561007001192	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001193	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007001194	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
561007001195	Helix-turn-helix domains; Region: HTH; cl00088
561007001196	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
561007001197	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007001198	metal ion-dependent adhesion site (MIDAS); other site
561007001199	FtsH Extracellular; Region: FtsH_ext; pfam06480
561007001200	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
561007001201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007001202	Walker A motif; other site
561007001203	ATP binding site [chemical binding]; other site
561007001204	Walker B motif; other site
561007001205	arginine finger; other site
561007001206	Peptidase family M41; Region: Peptidase_M41; pfam01434
561007001207	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
561007001208	homodecamer interface [polypeptide binding]; other site
561007001209	GTP cyclohydrolase I; Provisional; Region: PLN03044
561007001210	active site
561007001211	putative catalytic site residues [active]
561007001212	zinc binding site [ion binding]; other site
561007001213	GTP-CH-I/GFRP interaction surface; other site
561007001214	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
561007001215	dihydropteroate synthase; Region: DHPS; TIGR01496
561007001216	substrate binding pocket [chemical binding]; other site
561007001217	dimer interface [polypeptide binding]; other site
561007001218	inhibitor binding site; inhibition site
561007001219	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
561007001220	homooctamer interface [polypeptide binding]; other site
561007001221	active site
561007001222	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
561007001223	catalytic center binding site [active]
561007001224	ATP binding site [chemical binding]; other site
561007001225	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
561007001226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001227	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
561007001228	Pantoate-beta-alanine ligase; Region: PanC; cd00560
561007001229	pantoate--beta-alanine ligase; Region: panC; TIGR00018
561007001230	active site
561007001231	ATP-binding site [chemical binding]; other site
561007001232	pantoate-binding site; other site
561007001233	HXXH motif; other site
561007001234	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
561007001235	tetramerization interface [polypeptide binding]; other site
561007001236	active site
561007001237	Type III pantothenate kinase; Region: Pan_kinase; cl09130
561007001238	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
561007001239	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
561007001240	dimer interface [polypeptide binding]; other site
561007001241	putative anticodon binding site; other site
561007001242	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
561007001243	motif 1; other site
561007001244	dimer interface [polypeptide binding]; other site
561007001245	active site
561007001246	motif 2; other site
561007001247	motif 3; other site
561007001248	Lsr2; Region: Lsr2; pfam11774
561007001249	Clp protease ATP binding subunit; Region: clpC; CHL00095
561007001250	Clp amino terminal domain; Region: Clp_N; pfam02861
561007001251	Clp amino terminal domain; Region: Clp_N; pfam02861
561007001252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007001253	Walker A motif; other site
561007001254	ATP binding site [chemical binding]; other site
561007001255	Walker B motif; other site
561007001256	arginine finger; other site
561007001257	UvrB/uvrC motif; Region: UVR; pfam02151
561007001258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007001259	Walker A motif; other site
561007001260	ATP binding site [chemical binding]; other site
561007001261	Walker B motif; other site
561007001262	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
561007001263	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
561007001264	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
561007001265	putative ligand binding residues [chemical binding]; other site
561007001266	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
561007001267	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
561007001268	Walker A/P-loop; other site
561007001269	ATP binding site [chemical binding]; other site
561007001270	Q-loop/lid; other site
561007001271	ABC transporter signature motif; other site
561007001272	Walker B; other site
561007001273	D-loop; other site
561007001274	H-loop/switch region; other site
561007001275	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
561007001276	dimer interface [polypeptide binding]; other site
561007001277	putative PBP binding regions; other site
561007001278	ABC-ATPase subunit  interface; other site
561007001279	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
561007001280	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
561007001281	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007001282	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
561007001283	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007001284	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001285	Phosphoesterase family; Region: Phosphoesterase; cl15450
561007001286	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
561007001287	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
561007001288	conserved cys residue [active]
561007001289	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007001290	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
561007001291	endonuclease III; Region: ENDO3c; smart00478
561007001292	minor groove reading motif; other site
561007001293	helix-hairpin-helix signature motif; other site
561007001294	substrate binding pocket [chemical binding]; other site
561007001295	active site
561007001296	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
561007001297	active site clefts [active]
561007001298	zinc binding site [ion binding]; other site
561007001299	dimer interface [polypeptide binding]; other site
561007001300	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
561007001301	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
561007001302	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
561007001303	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
561007001304	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
561007001305	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007001306	CoenzymeA binding site [chemical binding]; other site
561007001307	subunit interaction site [polypeptide binding]; other site
561007001308	PHB binding site; other site
561007001309	DNA repair protein RadA; Provisional; Region: PRK11823
561007001310	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007001311	Walker A motif; other site
561007001312	ATP binding site [chemical binding]; other site
561007001313	Walker B motif; other site
561007001314	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
561007001315	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007001316	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007001317	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
561007001318	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
561007001319	substrate binding site; other site
561007001320	dimer interface; other site
561007001321	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
561007001322	homotrimer interaction site [polypeptide binding]; other site
561007001323	zinc binding site [ion binding]; other site
561007001324	CDP-binding sites; other site
561007001325	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
561007001326	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
561007001327	active site
561007001328	HIGH motif; other site
561007001329	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
561007001330	KMSKS motif; other site
561007001331	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
561007001332	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
561007001333	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
561007001334	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
561007001335	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
561007001336	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
561007001337	active site
561007001338	catalytic site [active]
561007001339	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
561007001340	putative active site [active]
561007001341	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
561007001342	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
561007001343	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007001344	Walker A/P-loop; other site
561007001345	ATP binding site [chemical binding]; other site
561007001346	Q-loop/lid; other site
561007001347	ABC transporter signature motif; other site
561007001348	Walker B; other site
561007001349	D-loop; other site
561007001350	H-loop/switch region; other site
561007001351	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
561007001352	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
561007001353	intersubunit interface [polypeptide binding]; other site
561007001354	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
561007001355	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007001356	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
561007001357	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
561007001358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001359	Helix-turn-helix domains; Region: HTH; cl00088
561007001360	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007001361	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007001362	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001363	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001364	active site
561007001365	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
561007001366	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
561007001367	FAD binding pocket [chemical binding]; other site
561007001368	FAD binding motif [chemical binding]; other site
561007001369	phosphate binding motif [ion binding]; other site
561007001370	beta-alpha-beta structure motif; other site
561007001371	NAD(p) ribose binding residues [chemical binding]; other site
561007001372	NAD binding pocket [chemical binding]; other site
561007001373	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
561007001374	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007001375	catalytic loop [active]
561007001376	iron binding site [ion binding]; other site
561007001377	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007001378	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
561007001379	Flavin binding site [chemical binding]; other site
561007001380	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
561007001381	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
561007001382	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
561007001383	active site
561007001384	Fe binding site [ion binding]; other site
561007001385	Flavin Reductases; Region: FlaRed; cl00801
561007001386	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
561007001387	agmatine deiminase; Region: agmatine_aguA; TIGR03380
561007001388	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
561007001389	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
561007001390	amphipathic channel; other site
561007001391	Asn-Pro-Ala signature motifs; other site
561007001392	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
561007001393	Predicted membrane protein [Function unknown]; Region: COG4270
561007001394	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007001395	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001396	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
561007001397	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007001398	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001399	active site
561007001400	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007001401	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001402	active site
561007001403	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
561007001404	AMP-binding enzyme; Region: AMP-binding; cl15778
561007001405	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007001406	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
561007001407	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
561007001408	FAD binding site [chemical binding]; other site
561007001409	substrate binding site [chemical binding]; other site
561007001410	catalytic base [active]
561007001411	short chain dehydrogenase; Provisional; Region: PRK07831
561007001412	classical (c) SDRs; Region: SDR_c; cd05233
561007001413	NAD(P) binding site [chemical binding]; other site
561007001414	active site
561007001415	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
561007001416	Helix-turn-helix domains; Region: HTH; cl00088
561007001417	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
561007001418	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007001419	dimer interface [polypeptide binding]; other site
561007001420	active site
561007001421	Nitronate monooxygenase; Region: NMO; pfam03060
561007001422	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
561007001423	FMN binding site [chemical binding]; other site
561007001424	substrate binding site [chemical binding]; other site
561007001425	putative catalytic residue [active]
561007001426	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
561007001427	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
561007001428	enoyl-CoA hydratase; Provisional; Region: PRK06495
561007001429	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007001430	substrate binding site [chemical binding]; other site
561007001431	oxyanion hole (OAH) forming residues; other site
561007001432	trimer interface [polypeptide binding]; other site
561007001433	short chain dehydrogenase; Provisional; Region: PRK07856
561007001434	classical (c) SDRs; Region: SDR_c; cd05233
561007001435	NAD(P) binding site [chemical binding]; other site
561007001436	active site
561007001437	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
561007001438	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
561007001439	homodimer interface [polypeptide binding]; other site
561007001440	NAD binding site [chemical binding]; other site
561007001441	active site
561007001442	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007001443	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007001444	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
561007001445	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007001446	dimer interface [polypeptide binding]; other site
561007001447	active site
561007001448	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007001449	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007001450	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001451	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007001452	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001453	active site
561007001454	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
561007001455	active site
561007001456	catalytic site [active]
561007001457	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
561007001458	DUF35 OB-fold domain; Region: DUF35; pfam01796
561007001459	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007001460	active site 2 [active]
561007001461	active site 1 [active]
561007001462	lipid-transfer protein; Provisional; Region: PRK07855
561007001463	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007001464	active site
561007001465	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
561007001466	enoyl-CoA hydratase; Region: PLN02864
561007001467	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007001468	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
561007001469	dimer interaction site [polypeptide binding]; other site
561007001470	substrate-binding tunnel; other site
561007001471	active site
561007001472	catalytic site [active]
561007001473	substrate binding site [chemical binding]; other site
561007001474	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
561007001475	hypothetical protein; Validated; Region: PRK07121
561007001476	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007001477	acetaldehyde dehydrogenase; Validated; Region: PRK08300
561007001478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001479	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
561007001480	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
561007001481	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
561007001482	active site
561007001483	catalytic residues [active]
561007001484	metal binding site [ion binding]; metal-binding site
561007001485	DmpG-like communication domain; Region: DmpG_comm; pfam07836
561007001486	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
561007001487	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
561007001488	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007001489	P-loop; other site
561007001490	Magnesium ion binding site [ion binding]; other site
561007001491	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
561007001492	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
561007001493	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
561007001494	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
561007001495	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
561007001496	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
561007001497	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
561007001498	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
561007001499	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
561007001500	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
561007001501	Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073
561007001502	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
561007001503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007001504	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
561007001505	Walker A motif; other site
561007001506	ATP binding site [chemical binding]; other site
561007001507	Walker B motif; other site
561007001508	arginine finger; other site
561007001509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007001510	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
561007001511	Walker A motif; other site
561007001512	ATP binding site [chemical binding]; other site
561007001513	Walker B motif; other site
561007001514	arginine finger; other site
561007001515	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
561007001516	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
561007001517	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
561007001518	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
561007001519	dimer interface [polypeptide binding]; other site
561007001520	putative functional site; other site
561007001521	putative MPT binding site; other site
561007001522	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
561007001523	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007001524	active site
561007001525	motif I; other site
561007001526	motif II; other site
561007001527	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007001528	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
561007001529	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007001530	short chain dehydrogenase; Provisional; Region: PRK06197
561007001531	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
561007001532	putative NAD(P) binding site [chemical binding]; other site
561007001533	active site
561007001534	Cupin domain; Region: Cupin_2; cl09118
561007001535	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
561007001536	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007001537	ATP binding site [chemical binding]; other site
561007001538	putative Mg++ binding site [ion binding]; other site
561007001539	short chain dehydrogenase; Provisional; Region: PRK06197
561007001540	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
561007001541	putative NAD(P) binding site [chemical binding]; other site
561007001542	active site
561007001543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001544	Helix-turn-helix domains; Region: HTH; cl00088
561007001545	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001546	hypothetical protein; Validated; Region: PRK05868
561007001547	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
561007001548	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
561007001549	ring oligomerisation interface [polypeptide binding]; other site
561007001550	ATP/Mg binding site [chemical binding]; other site
561007001551	stacking interactions; other site
561007001552	hinge regions; other site
561007001553	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
561007001554	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
561007001555	MoxR-like ATPases [General function prediction only]; Region: COG0714
561007001556	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007001557	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
561007001558	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007001559	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007001560	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
561007001561	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
561007001562	FcoT-like thioesterase domain; Region: FcoT; pfam10862
561007001563	acyl-CoA synthetase; Validated; Region: PRK05857
561007001564	AMP-binding enzyme; Region: AMP-binding; cl15778
561007001565	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007001566	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
561007001567	AMP-binding enzyme; Region: AMP-binding; cl15778
561007001568	thioester reductase domain; Region: Thioester-redct; TIGR01746
561007001569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001570	NAD(P) binding site [chemical binding]; other site
561007001571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001572	active site
561007001573	active site
561007001574	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007001575	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
561007001576	metal-binding site [ion binding]
561007001577	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007001578	PPE family; Region: PPE; pfam00823
561007001579	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
561007001580	Domain of unknown function (DUF202); Region: DUF202; cl09954
561007001581	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007001582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007001583	active site
561007001584	phosphorylation site [posttranslational modification]
561007001585	intermolecular recognition site; other site
561007001586	dimerization interface [polypeptide binding]; other site
561007001587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007001588	DNA binding site [nucleotide binding]
561007001589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
561007001590	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
561007001591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007001592	dimer interface [polypeptide binding]; other site
561007001593	phosphorylation site [posttranslational modification]
561007001594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007001595	ATP binding site [chemical binding]; other site
561007001596	Mg2+ binding site [ion binding]; other site
561007001597	G-X-G motif; other site
561007001598	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
561007001599	nucleotide binding site/active site [active]
561007001600	HIT family signature motif; other site
561007001601	catalytic residue [active]
561007001602	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
561007001603	EamA-like transporter family; Region: EamA; cl01037
561007001604	EamA-like transporter family; Region: EamA; cl01037
561007001605	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007001606	Helix-turn-helix domains; Region: HTH; cl00088
561007001607	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
561007001608	putative dimerization interface [polypeptide binding]; other site
561007001609	short chain dehydrogenase; Validated; Region: PRK05855
561007001610	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001611	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
561007001612	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007001613	active site
561007001614	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007001615	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001616	Helix-turn-helix domains; Region: HTH; cl00088
561007001617	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
561007001618	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
561007001619	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007001620	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
561007001621	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
561007001622	Predicted esterase [General function prediction only]; Region: COG0627
561007001623	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001624	aspartate aminotransferase; Provisional; Region: PRK05764
561007001625	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007001626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007001627	homodimer interface [polypeptide binding]; other site
561007001628	catalytic residue [active]
561007001629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
561007001630	Helix-turn-helix domains; Region: HTH; cl00088
561007001631	adenylosuccinate lyase; Region: purB; TIGR00928
561007001632	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
561007001633	tetramer interface [polypeptide binding]; other site
561007001634	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
561007001635	ATP binding site [chemical binding]; other site
561007001636	active site
561007001637	substrate binding site [chemical binding]; other site
561007001638	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
561007001639	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001640	short chain dehydrogenase; Provisional; Region: PRK06940
561007001641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001642	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001643	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
561007001644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007001645	putative substrate translocation pore; other site
561007001646	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
561007001647	catalytic residues [active]
561007001648	dimer interface [polypeptide binding]; other site
561007001649	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
561007001650	Predicted deacetylase [General function prediction only]; Region: COG3233
561007001651	putative active site [active]
561007001652	putative Zn binding site [ion binding]; other site
561007001653	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
561007001654	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007001655	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
561007001656	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
561007001657	putative active site [active]
561007001658	catalytic triad [active]
561007001659	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
561007001660	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
561007001661	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
561007001662	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
561007001663	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
561007001664	active site
561007001665	metal binding site [ion binding]; metal-binding site
561007001666	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
561007001667	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007001668	DoxX; Region: DoxX; cl00976
561007001669	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
561007001670	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
561007001671	dimerization interface [polypeptide binding]; other site
561007001672	ATP binding site [chemical binding]; other site
561007001673	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
561007001674	dimerization interface [polypeptide binding]; other site
561007001675	ATP binding site [chemical binding]; other site
561007001676	Predicted membrane protein [Function unknown]; Region: COG4425
561007001677	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
561007001678	CAAX protease self-immunity; Region: Abi; cl00558
561007001679	amidophosphoribosyltransferase; Provisional; Region: PRK07847
561007001680	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
561007001681	active site
561007001682	tetramer interface [polypeptide binding]; other site
561007001683	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007001684	active site
561007001685	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
561007001686	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007001687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007001688	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007001689	Helix-turn-helix domains; Region: HTH; cl00088
561007001690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001691	NAD(P) binding site [chemical binding]; other site
561007001692	active site
561007001693	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
561007001694	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
561007001695	putative NADP binding site [chemical binding]; other site
561007001696	putative substrate binding site [chemical binding]; other site
561007001697	active site
561007001698	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
561007001699	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
561007001700	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
561007001701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007001702	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
561007001703	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
561007001704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007001705	dimer interface [polypeptide binding]; other site
561007001706	conserved gate region; other site
561007001707	ABC-ATPase subunit interface; other site
561007001708	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
561007001709	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
561007001710	Walker A/P-loop; other site
561007001711	ATP binding site [chemical binding]; other site
561007001712	Q-loop/lid; other site
561007001713	ABC transporter signature motif; other site
561007001714	Walker B; other site
561007001715	D-loop; other site
561007001716	H-loop/switch region; other site
561007001717	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
561007001718	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
561007001719	Walker A/P-loop; other site
561007001720	ATP binding site [chemical binding]; other site
561007001721	Q-loop/lid; other site
561007001722	ABC transporter signature motif; other site
561007001723	Walker B; other site
561007001724	D-loop; other site
561007001725	H-loop/switch region; other site
561007001726	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
561007001727	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001728	amidase; Provisional; Region: PRK07869
561007001729	Amidase; Region: Amidase; cl11426
561007001730	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
561007001731	Helix-turn-helix domains; Region: HTH; cl00088
561007001732	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
561007001733	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
561007001734	iron-sulfur cluster [ion binding]; other site
561007001735	[2Fe-2S] cluster binding site [ion binding]; other site
561007001736	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
561007001737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001738	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
561007001739	intersubunit interface [polypeptide binding]; other site
561007001740	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
561007001741	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
561007001742	dimerization interface [polypeptide binding]; other site
561007001743	putative ATP binding site [chemical binding]; other site
561007001744	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
561007001745	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
561007001746	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
561007001747	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
561007001748	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
561007001749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007001750	catalytic residue [active]
561007001751	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
561007001752	heme-binding site [chemical binding]; other site
561007001753	MspA; Region: MspA; pfam09203
561007001754	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
561007001755	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007001756	active site
561007001757	metal binding site [ion binding]; metal-binding site
561007001758	Helix-turn-helix domain; Region: HTH_18; pfam12833
561007001759	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
561007001760	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
561007001761	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
561007001762	active site residue [active]
561007001763	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
561007001764	active site residue [active]
561007001765	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
561007001766	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
561007001767	catalytic residues [active]
561007001768	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
561007001769	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007001770	DNA binding site [nucleotide binding]
561007001771	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
561007001772	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007001773	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007001774	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007001775	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
561007001776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007001777	dimer interface [polypeptide binding]; other site
561007001778	conserved gate region; other site
561007001779	putative PBP binding loops; other site
561007001780	ABC-ATPase subunit interface; other site
561007001781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007001782	dimer interface [polypeptide binding]; other site
561007001783	conserved gate region; other site
561007001784	putative PBP binding loops; other site
561007001785	ABC-ATPase subunit interface; other site
561007001786	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
561007001787	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
561007001788	Walker A/P-loop; other site
561007001789	ATP binding site [chemical binding]; other site
561007001790	Q-loop/lid; other site
561007001791	ABC transporter signature motif; other site
561007001792	Walker B; other site
561007001793	D-loop; other site
561007001794	H-loop/switch region; other site
561007001795	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007001796	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
561007001797	putative NAD(P) binding site [chemical binding]; other site
561007001798	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
561007001799	PhoU domain; Region: PhoU; pfam01895
561007001800	PhoU domain; Region: PhoU; pfam01895
561007001801	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
561007001802	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
561007001803	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
561007001804	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
561007001805	FMN binding site [chemical binding]; other site
561007001806	active site
561007001807	catalytic residues [active]
561007001808	substrate binding site [chemical binding]; other site
561007001809	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
561007001810	homodimer interface [polypeptide binding]; other site
561007001811	putative substrate binding pocket [chemical binding]; other site
561007001812	diiron center [ion binding]; other site
561007001813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001814	Helix-turn-helix domains; Region: HTH; cl00088
561007001815	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007001816	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007001817	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
561007001818	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001819	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
561007001820	Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508
561007001821	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
561007001822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001823	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
561007001824	Helix-turn-helix domains; Region: HTH; cl00088
561007001825	oxidoreductase; Provisional; Region: PRK06196
561007001826	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001827	NAD(P) binding site [chemical binding]; other site
561007001828	active site
561007001829	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
561007001830	EamA-like transporter family; Region: EamA; cl01037
561007001831	Cupin domain; Region: Cupin_2; cl09118
561007001832	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007001833	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007001834	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007001835	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001836	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007001837	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007001838	non-specific DNA binding site [nucleotide binding]; other site
561007001839	salt bridge; other site
561007001840	sequence-specific DNA binding site [nucleotide binding]; other site
561007001841	Cupin domain; Region: Cupin_2; cl09118
561007001842	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
561007001843	putative deacylase active site [active]
561007001844	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007001845	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007001846	putative substrate translocation pore; other site
561007001847	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
561007001848	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007001849	PPE family; Region: PPE; pfam00823
561007001850	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
561007001851	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007001852	DNA-binding site [nucleotide binding]; DNA binding site
561007001853	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007001854	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007001855	homodimer interface [polypeptide binding]; other site
561007001856	catalytic residue [active]
561007001857	EamA-like transporter family; Region: EamA; cl01037
561007001858	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007001859	Helix-turn-helix domains; Region: HTH; cl00088
561007001860	Bacterial transcriptional regulator; Region: IclR; pfam01614
561007001861	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007001862	Helix-turn-helix domains; Region: HTH; cl00088
561007001863	Bacterial transcriptional regulator; Region: IclR; pfam01614
561007001864	Amino acid permease; Region: AA_permease_2; pfam13520
561007001865	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
561007001866	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
561007001867	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007001868	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
561007001869	tetrameric interface [polypeptide binding]; other site
561007001870	NAD binding site [chemical binding]; other site
561007001871	catalytic residues [active]
561007001872	substrate binding site [chemical binding]; other site
561007001873	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
561007001874	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001875	Predicted amidohydrolase [General function prediction only]; Region: COG0388
561007001876	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
561007001877	putative active site [active]
561007001878	catalytic triad [active]
561007001879	putative dimer interface [polypeptide binding]; other site
561007001880	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
561007001881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001882	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
561007001883	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007001884	inhibitor-cofactor binding pocket; inhibition site
561007001885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007001886	catalytic residue [active]
561007001887	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007001888	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007001889	active site
561007001890	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
561007001891	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007001892	NAD(P) binding site [chemical binding]; other site
561007001893	catalytic residues [active]
561007001894	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
561007001895	CoA-transferase family III; Region: CoA_transf_3; pfam02515
561007001896	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
561007001897	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
561007001898	Helix-turn-helix domains; Region: HTH; cl00088
561007001899	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001900	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007001901	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
561007001902	classical (c) SDRs; Region: SDR_c; cd05233
561007001903	NAD(P) binding site [chemical binding]; other site
561007001904	active site
561007001905	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
561007001906	phosphate binding site [ion binding]; other site
561007001907	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
561007001908	FMN binding site [chemical binding]; other site
561007001909	active site
561007001910	substrate binding site [chemical binding]; other site
561007001911	catalytic residue [active]
561007001912	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
561007001913	putative hydrophobic ligand binding site [chemical binding]; other site
561007001914	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001915	Helix-turn-helix domains; Region: HTH; cl00088
561007001916	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
561007001917	classical (c) SDRs; Region: SDR_c; cd05233
561007001918	NAD(P) binding site [chemical binding]; other site
561007001919	active site
561007001920	enoyl-CoA hydratase; Provisional; Region: PRK06688
561007001921	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007001922	substrate binding site [chemical binding]; other site
561007001923	oxyanion hole (OAH) forming residues; other site
561007001924	trimer interface [polypeptide binding]; other site
561007001925	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007001926	Helix-turn-helix domains; Region: HTH; cl00088
561007001927	enoyl-CoA hydratase; Provisional; Region: PRK07799
561007001928	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007001929	substrate binding site [chemical binding]; other site
561007001930	oxyanion hole (OAH) forming residues; other site
561007001931	trimer interface [polypeptide binding]; other site
561007001932	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
561007001933	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007001934	active site
561007001935	lipid-transfer protein; Provisional; Region: PRK07937
561007001936	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007001937	active site
561007001938	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
561007001939	DUF35 OB-fold domain; Region: DUF35; pfam01796
561007001940	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
561007001941	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
561007001942	CoA-transferase family III; Region: CoA_transf_3; pfam02515
561007001943	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007001944	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007001945	aminotransferase; Validated; Region: PRK07777
561007001946	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007001947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007001948	homodimer interface [polypeptide binding]; other site
561007001949	catalytic residue [active]
561007001950	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
561007001951	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007001952	dimer interface [polypeptide binding]; other site
561007001953	active site
561007001954	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
561007001955	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007001956	substrate binding site [chemical binding]; other site
561007001957	oxyanion hole (OAH) forming residues; other site
561007001958	trimer interface [polypeptide binding]; other site
561007001959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001960	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
561007001961	peptide synthase; Provisional; Region: PRK12316
561007001962	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
561007001963	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007001964	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
561007001965	Transport protein; Region: actII; TIGR00833
561007001966	Protein export membrane protein; Region: SecD_SecF; cl14618
561007001967	tetracycline repressor protein TetR; Provisional; Region: PRK13756
561007001968	Helix-turn-helix domains; Region: HTH; cl00088
561007001969	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
561007001970	hypothetical protein; Provisional; Region: PRK06834
561007001971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007001972	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007001973	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
561007001974	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007001975	hydrophobic ligand binding site; other site
561007001976	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
561007001977	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
561007001978	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007001979	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007001980	ATP binding site [chemical binding]; other site
561007001981	putative Mg++ binding site [ion binding]; other site
561007001982	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007001983	nucleotide binding region [chemical binding]; other site
561007001984	ATP-binding site [chemical binding]; other site
561007001985	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
561007001986	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
561007001987	WYL domain; Region: WYL; cl14852
561007001988	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
561007001989	trimer interface [polypeptide binding]; other site
561007001990	dimer interface [polypeptide binding]; other site
561007001991	putative active site [active]
561007001992	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
561007001993	MPT binding site; other site
561007001994	trimer interface [polypeptide binding]; other site
561007001995	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
561007001996	MoaE homodimer interface [polypeptide binding]; other site
561007001997	MoaD interaction [polypeptide binding]; other site
561007001998	active site residues [active]
561007001999	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
561007002000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007002001	Methyltransferase domain; Region: Methyltransf_31; pfam13847
561007002002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007002003	S-adenosylmethionine binding site [chemical binding]; other site
561007002004	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
561007002005	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
561007002006	MoaE interaction surface [polypeptide binding]; other site
561007002007	MoeB interaction surface [polypeptide binding]; other site
561007002008	thiocarboxylated glycine; other site
561007002009	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
561007002010	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007002011	FeS/SAM binding site; other site
561007002012	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
561007002013	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
561007002014	DNA-binding site [nucleotide binding]; DNA binding site
561007002015	RNA-binding motif; other site
561007002016	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
561007002017	A new structural DNA glycosylase; Region: AlkD_like; cd06561
561007002018	active site
561007002019	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
561007002020	H+ Antiporter protein; Region: 2A0121; TIGR00900
561007002021	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
561007002022	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
561007002023	hydrophobic ligand binding site; other site
561007002024	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
561007002025	Transcriptional regulators [Transcription]; Region: MarR; COG1846
561007002026	Helix-turn-helix domains; Region: HTH; cl00088
561007002027	H+ Antiporter protein; Region: 2A0121; TIGR00900
561007002028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007002029	putative substrate translocation pore; other site
561007002030	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
561007002031	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
561007002032	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
561007002033	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
561007002034	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
561007002035	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
561007002036	Domain of unknown function (DUF202); Region: DUF202; cl09954
561007002037	fumarylacetoacetase; Region: PLN02856
561007002038	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
561007002039	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007002040	Cupin domain; Region: Cupin_2; cl09118
561007002041	Transcriptional regulators [Transcription]; Region: MarR; COG1846
561007002042	Helix-turn-helix domains; Region: HTH; cl00088
561007002043	Helix-turn-helix domains; Region: HTH; cl00088
561007002044	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
561007002045	AsnC family; Region: AsnC_trans_reg; pfam01037
561007002046	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
561007002047	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
561007002048	dimer interface [polypeptide binding]; other site
561007002049	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
561007002050	active site
561007002051	Fe binding site [ion binding]; other site
561007002052	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
561007002053	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
561007002054	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007002055	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007002056	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
561007002057	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
561007002058	E3 interaction surface; other site
561007002059	lipoyl attachment site [posttranslational modification]; other site
561007002060	e3 binding domain; Region: E3_binding; pfam02817
561007002061	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
561007002062	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
561007002063	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
561007002064	alpha subunit interface [polypeptide binding]; other site
561007002065	TPP binding site [chemical binding]; other site
561007002066	heterodimer interface [polypeptide binding]; other site
561007002067	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
561007002068	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
561007002069	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
561007002070	tetramer interface [polypeptide binding]; other site
561007002071	TPP-binding site [chemical binding]; other site
561007002072	heterodimer interface [polypeptide binding]; other site
561007002073	phosphorylation loop region [posttranslational modification]
561007002074	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
561007002075	Helix-turn-helix domains; Region: HTH; cl00088
561007002076	AsnC family; Region: AsnC_trans_reg; pfam01037
561007002077	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
561007002078	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
561007002079	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
561007002080	substrate binding site [chemical binding]; other site
561007002081	dimer interface [polypeptide binding]; other site
561007002082	NADP binding site [chemical binding]; other site
561007002083	catalytic residues [active]
561007002084	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007002085	active site 2 [active]
561007002086	active site 1 [active]
561007002087	Helix-turn-helix domains; Region: HTH; cl00088
561007002088	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
561007002089	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007002090	dimer interface [polypeptide binding]; other site
561007002091	active site
561007002092	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
561007002093	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007002094	substrate binding site [chemical binding]; other site
561007002095	oxyanion hole (OAH) forming residues; other site
561007002096	trimer interface [polypeptide binding]; other site
561007002097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002098	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
561007002099	enoyl-CoA hydratase; Provisional; Region: PRK08140
561007002100	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007002101	substrate binding site [chemical binding]; other site
561007002102	oxyanion hole (OAH) forming residues; other site
561007002103	trimer interface [polypeptide binding]; other site
561007002104	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
561007002105	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
561007002106	Phenylacetic acid degradation B; Region: PaaB; cl01371
561007002107	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
561007002108	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
561007002109	Domain of unknown function DUF59; Region: DUF59; cl00941
561007002110	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
561007002111	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
561007002112	FAD binding pocket [chemical binding]; other site
561007002113	FAD binding motif [chemical binding]; other site
561007002114	phosphate binding motif [ion binding]; other site
561007002115	beta-alpha-beta structure motif; other site
561007002116	NAD(p) ribose binding residues [chemical binding]; other site
561007002117	NAD binding pocket [chemical binding]; other site
561007002118	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
561007002119	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007002120	catalytic loop [active]
561007002121	iron binding site [ion binding]; other site
561007002122	AMP-binding enzyme; Region: AMP-binding; cl15778
561007002123	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
561007002124	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
561007002125	Helix-turn-helix domains; Region: HTH; cl00088
561007002126	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
561007002127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002128	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007002129	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
561007002130	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007002131	Putative catalytic domain of uncharacterized bacterial and eukaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_3; cd10942
561007002132	putative active site [active]
561007002133	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007002134	Secretory lipase; Region: LIP; pfam03583
561007002135	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
561007002136	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
561007002137	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007002138	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007002139	OsmC-like protein; Region: OsmC; cl00767
561007002140	Transcriptional regulators [Transcription]; Region: MarR; COG1846
561007002141	Helix-turn-helix domains; Region: HTH; cl00088
561007002142	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
561007002143	Ligand binding site; other site
561007002144	Ligand binding site; other site
561007002145	Ligand binding site; other site
561007002146	Putative Catalytic site; other site
561007002147	DXD motif; other site
561007002148	GtrA-like protein; Region: GtrA; cl00971
561007002149	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
561007002150	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007002151	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
561007002152	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007002153	catalytic residue [active]
561007002154	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007002155	ferredoxin-NADP+ reductase; Region: PLN02852
561007002156	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
561007002157	putative dimer interface [polypeptide binding]; other site
561007002158	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007002159	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
561007002160	Citrate synthase; Region: Citrate_synt; pfam00285
561007002161	oxalacetate binding site [chemical binding]; other site
561007002162	citrylCoA binding site [chemical binding]; other site
561007002163	coenzyme A binding site [chemical binding]; other site
561007002164	catalytic triad [active]
561007002165	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
561007002166	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007002167	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
561007002168	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007002169	acyl-CoA synthetase; Validated; Region: PRK05850
561007002170	AMP-binding enzyme; Region: AMP-binding; cl15778
561007002171	PE-PPE domain; Region: PE-PPE; pfam08237
561007002172	Transport protein; Region: actII; TIGR00833
561007002173	Protein export membrane protein; Region: SecD_SecF; cl14618
561007002174	Condensation domain; Region: Condensation; pfam00668
561007002175	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
561007002176	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007002177	active site
561007002178	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007002179	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
561007002180	putative NADP binding site [chemical binding]; other site
561007002181	active site
561007002182	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007002183	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
561007002184	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007002185	active site
561007002186	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007002187	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
561007002188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002189	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
561007002190	Enoylreductase; Region: PKS_ER; smart00829
561007002191	NAD(P) binding site [chemical binding]; other site
561007002192	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
561007002193	putative NADP binding site [chemical binding]; other site
561007002194	active site
561007002195	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007002196	enterobactin exporter EntS; Provisional; Region: PRK10489
561007002197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
561007002198	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088
561007002199	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
561007002200	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
561007002201	conserved cys residue [active]
561007002202	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
561007002203	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
561007002204	conserved cys residue [active]
561007002205	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
561007002206	dimer interface [polypeptide binding]; other site
561007002207	Citrate synthase; Region: Citrate_synt; pfam00285
561007002208	active site
561007002209	citrylCoA binding site [chemical binding]; other site
561007002210	NADH binding [chemical binding]; other site
561007002211	cationic pore residues; other site
561007002212	oxalacetate/citrate binding site [chemical binding]; other site
561007002213	coenzyme A binding site [chemical binding]; other site
561007002214	catalytic triad [active]
561007002215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007002216	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007002217	putative substrate translocation pore; other site
561007002218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007002219	Transcriptional regulators [Transcription]; Region: MarR; COG1846
561007002220	Helix-turn-helix domains; Region: HTH; cl00088
561007002221	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007002222	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
561007002223	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
561007002224	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007002225	inhibitor-cofactor binding pocket; inhibition site
561007002226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007002227	catalytic residue [active]
561007002228	Amino acid permease; Region: AA_permease; pfam00324
561007002229	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007002230	Phosphotransferase enzyme family; Region: APH; pfam01636
561007002231	short chain dehydrogenase; Provisional; Region: PRK12829
561007002232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002233	NAD(P) binding site [chemical binding]; other site
561007002234	active site
561007002235	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
561007002236	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007002237	DNA-binding site [nucleotide binding]; DNA binding site
561007002238	UTRA domain; Region: UTRA; cl01230
561007002239	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
561007002240	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
561007002241	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007002242	dimer interface [polypeptide binding]; other site
561007002243	phosphorylation site [posttranslational modification]
561007002244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007002245	ATP binding site [chemical binding]; other site
561007002246	Mg2+ binding site [ion binding]; other site
561007002247	G-X-G motif; other site
561007002248	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007002249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007002250	active site
561007002251	phosphorylation site [posttranslational modification]
561007002252	intermolecular recognition site; other site
561007002253	dimerization interface [polypeptide binding]; other site
561007002254	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007002255	DNA binding site [nucleotide binding]
561007002256	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007002257	enoyl-CoA hydratase; Provisional; Region: PRK06688
561007002258	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007002259	substrate binding site [chemical binding]; other site
561007002260	oxyanion hole (OAH) forming residues; other site
561007002261	trimer interface [polypeptide binding]; other site
561007002262	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007002263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007002264	S-adenosylmethionine binding site [chemical binding]; other site
561007002265	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
561007002266	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
561007002267	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007002268	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007002269	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
561007002270	Secretory lipase; Region: LIP; pfam03583
561007002271	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
561007002272	hydrophobic ligand binding site; other site
561007002273	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
561007002274	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007002275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
561007002276	Helix-turn-helix domains; Region: HTH; cl00088
561007002277	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
561007002278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007002279	putative substrate translocation pore; other site
561007002280	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
561007002281	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007002282	CoenzymeA binding site [chemical binding]; other site
561007002283	subunit interaction site [polypeptide binding]; other site
561007002284	PHB binding site; other site
561007002285	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
561007002286	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007002287	NAD(P) binding site [chemical binding]; other site
561007002288	catalytic residues [active]
561007002289	Protein of unknown function (DUF779); Region: DUF779; cl01432
561007002290	Protein of unknown function (DUF328); Region: DUF328; cl01143
561007002291	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
561007002292	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007002293	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
561007002294	DNA polymerase IV; Validated; Region: PRK03858
561007002295	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
561007002296	active site
561007002297	DNA binding site [nucleotide binding]
561007002298	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007002299	Helix-turn-helix domains; Region: HTH; cl00088
561007002300	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007002301	substrate binding site [chemical binding]; other site
561007002302	oxyanion hole (OAH) forming residues; other site
561007002303	trimer interface [polypeptide binding]; other site
561007002304	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
561007002305	active site
561007002306	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
561007002307	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
561007002308	NAD(P) binding site [chemical binding]; other site
561007002309	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007002310	Helix-turn-helix domains; Region: HTH; cl00088
561007002311	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007002312	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007002313	dimerization interface [polypeptide binding]; other site
561007002314	putative DNA binding site [nucleotide binding]; other site
561007002315	putative Zn2+ binding site [ion binding]; other site
561007002316	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
561007002317	putative hydrophobic ligand binding site [chemical binding]; other site
561007002318	Transport protein; Region: actII; TIGR00833
561007002319	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007002320	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007002321	Helix-turn-helix domains; Region: HTH; cl00088
561007002322	Domain of unknown function (DUF222); Region: DUF222; pfam02720
561007002323	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
561007002324	active site
561007002325	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
561007002326	ArsC family; Region: ArsC; pfam03960
561007002327	catalytic residues [active]
561007002328	Helix-turn-helix domains; Region: HTH; cl00088
561007002329	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
561007002330	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
561007002331	dimerization interface [polypeptide binding]; other site
561007002332	substrate binding pocket [chemical binding]; other site
561007002333	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
561007002334	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
561007002335	putative NAD(P) binding site [chemical binding]; other site
561007002336	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007002337	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
561007002338	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
561007002339	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
561007002340	Helix-turn-helix domains; Region: HTH; cl00088
561007002341	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
561007002342	dimerization interface [polypeptide binding]; other site
561007002343	formate dehydrogenase; Provisional; Region: PRK07574
561007002344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002345	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
561007002346	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007002347	dimer interface [polypeptide binding]; other site
561007002348	active site
561007002349	Mannan-binding protein; Region: MVL; pfam12151
561007002350	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
561007002351	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007002352	mce related protein; Region: MCE; pfam02470
561007002353	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007002354	mce related protein; Region: MCE; pfam02470
561007002355	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
561007002356	mce related protein; Region: MCE; pfam02470
561007002357	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007002358	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
561007002359	mce related protein; Region: MCE; pfam02470
561007002360	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007002361	mce related protein; Region: MCE; pfam02470
561007002362	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
561007002363	mce related protein; Region: MCE; pfam02470
561007002364	Permease; Region: Permease; cl00510
561007002365	Permease; Region: Permease; cl00510
561007002366	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
561007002367	putative ADP-binding pocket [chemical binding]; other site
561007002368	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
561007002369	putative active site [active]
561007002370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
561007002371	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
561007002372	MatE; Region: MatE; cl10513
561007002373	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
561007002374	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
561007002375	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
561007002376	Bacterial sugar transferase; Region: Bac_transf; cl00939
561007002377	Helix-turn-helix domains; Region: HTH; cl00088
561007002378	Predicted esterase [General function prediction only]; Region: COG0627
561007002379	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007002380	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007002381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007002382	Helix-turn-helix domains; Region: HTH; cl00088
561007002383	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
561007002384	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
561007002385	cyanate hydratase; Validated; Region: PRK02866
561007002386	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
561007002387	oligomer interface [polypeptide binding]; other site
561007002388	active site
561007002389	Helix-turn-helix domains; Region: HTH; cl00088
561007002390	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
561007002391	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
561007002392	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
561007002393	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
561007002394	putative DNA binding site [nucleotide binding]; other site
561007002395	putative homodimer interface [polypeptide binding]; other site
561007002396	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
561007002397	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
561007002398	nucleotide binding site [chemical binding]; other site
561007002399	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
561007002400	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
561007002401	active site
561007002402	DNA binding site [nucleotide binding]
561007002403	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
561007002404	DNA binding site [nucleotide binding]
561007002405	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007002406	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007002407	Helix-turn-helix domains; Region: HTH; cl00088
561007002408	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007002409	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
561007002410	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
561007002411	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
561007002412	putative DNA binding site [nucleotide binding]; other site
561007002413	catalytic residue [active]
561007002414	putative H2TH interface [polypeptide binding]; other site
561007002415	putative catalytic residues [active]
561007002416	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
561007002417	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
561007002418	short chain dehydrogenase; Provisional; Region: PRK08251
561007002419	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002420	NAD(P) binding site [chemical binding]; other site
561007002421	active site
561007002422	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007002423	active site
561007002424	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007002425	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
561007002426	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
561007002427	D-pathway; other site
561007002428	Putative ubiquinol binding site [chemical binding]; other site
561007002429	Low-spin heme (heme b) binding site [chemical binding]; other site
561007002430	Putative water exit pathway; other site
561007002431	Binuclear center (heme o3/CuB) [ion binding]; other site
561007002432	K-pathway; other site
561007002433	Putative proton exit pathway; other site
561007002434	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
561007002435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002436	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007002437	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
561007002438	active site
561007002439	metal binding site [ion binding]; metal-binding site
561007002440	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
561007002441	CGNR zinc finger; Region: zf-CGNR; pfam11706
561007002442	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
561007002443	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007002444	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
561007002445	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
561007002446	inhibitor site; inhibition site
561007002447	active site
561007002448	dimer interface [polypeptide binding]; other site
561007002449	catalytic residue [active]
561007002450	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
561007002451	intersubunit interface [polypeptide binding]; other site
561007002452	active site
561007002453	Zn2+ binding site [ion binding]; other site
561007002454	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007002455	Cupin domain; Region: Cupin_2; cl09118
561007002456	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
561007002457	SelR domain; Region: SelR; pfam01641
561007002458	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
561007002459	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
561007002460	active site
561007002461	dimer interface [polypeptide binding]; other site
561007002462	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
561007002463	dimer interface [polypeptide binding]; other site
561007002464	active site
561007002465	Chorismate mutase type II; Region: CM_2; cl00693
561007002466	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
561007002467	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007002468	Family description; Region: UvrD_C_2; cl15862
561007002469	Peptidase family M23; Region: Peptidase_M23; pfam01551
561007002470	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
561007002471	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007002472	CoA-ligase; Region: Ligase_CoA; cl02894
561007002473	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
561007002474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002475	CoA-ligase; Region: Ligase_CoA; cl02894
561007002476	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
561007002477	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007002478	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
561007002479	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
561007002480	active site
561007002481	dimer interface [polypeptide binding]; other site
561007002482	non-prolyl cis peptide bond; other site
561007002483	insertion regions; other site
561007002484	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
561007002485	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
561007002486	active site
561007002487	substrate binding site [chemical binding]; other site
561007002488	cosubstrate binding site; other site
561007002489	catalytic site [active]
561007002490	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
561007002491	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
561007002492	purine monophosphate binding site [chemical binding]; other site
561007002493	dimer interface [polypeptide binding]; other site
561007002494	putative catalytic residues [active]
561007002495	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
561007002496	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
561007002497	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
561007002498	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
561007002499	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
561007002500	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
561007002501	enoyl-CoA hydratase; Provisional; Region: PRK07827
561007002502	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007002503	substrate binding site [chemical binding]; other site
561007002504	oxyanion hole (OAH) forming residues; other site
561007002505	trimer interface [polypeptide binding]; other site
561007002506	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007002507	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007002508	active site
561007002509	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
561007002510	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
561007002511	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007002512	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
561007002513	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
561007002514	carboxyltransferase (CT) interaction site; other site
561007002515	biotinylation site [posttranslational modification]; other site
561007002516	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
561007002517	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007002518	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007002519	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007002520	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007002521	active site
561007002522	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
561007002523	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
561007002524	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007002525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007002526	active site
561007002527	phosphorylation site [posttranslational modification]
561007002528	intermolecular recognition site; other site
561007002529	dimerization interface [polypeptide binding]; other site
561007002530	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007002531	DNA binding site [nucleotide binding]
561007002532	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
561007002533	dimerization interface [polypeptide binding]; other site
561007002534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007002535	dimer interface [polypeptide binding]; other site
561007002536	phosphorylation site [posttranslational modification]
561007002537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007002538	ATP binding site [chemical binding]; other site
561007002539	Mg2+ binding site [ion binding]; other site
561007002540	G-X-G motif; other site
561007002541	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
561007002542	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
561007002543	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
561007002544	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
561007002545	MPT binding site; other site
561007002546	trimer interface [polypeptide binding]; other site
561007002547	MspA; Region: MspA; pfam09203
561007002548	MspA; Region: MspA; pfam09203
561007002549	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
561007002550	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
561007002551	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
561007002552	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
561007002553	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
561007002554	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
561007002555	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
561007002556	active site
561007002557	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
561007002558	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
561007002559	dimer interface [polypeptide binding]; other site
561007002560	putative functional site; other site
561007002561	putative MPT binding site; other site
561007002562	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007002563	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
561007002564	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007002565	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007002566	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
561007002567	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007002568	catalytic residue [active]
561007002569	DNA-sulfur modification-associated; Region: DndB; cl14002
561007002570	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
561007002571	Active Sites [active]
561007002572	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
561007002573	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007002574	Walker A/P-loop; other site
561007002575	ATP binding site [chemical binding]; other site
561007002576	Domain of unknown function (DUF1832); Region: DUF1832; cl07463
561007002577	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
561007002578	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007002579	Protein of unknown function DUF262; Region: DUF262; cl14890
561007002580	Protein of unknown function DUF262; Region: DUF262; cl14890
561007002581	Cupin domain; Region: Cupin_2; cl09118
561007002582	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007002583	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
561007002584	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
561007002585	NAD(P) binding site [chemical binding]; other site
561007002586	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007002587	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007002588	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007002589	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007002590	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007002591	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
561007002592	Amidinotransferase; Region: Amidinotransf; cl12043
561007002593	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
561007002594	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
561007002595	Predicted methyltransferases [General function prediction only]; Region: COG0313
561007002596	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007002597	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
561007002598	chorismate binding enzyme; Region: Chorismate_bind; cl10555
561007002599	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007002600	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
561007002601	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007002602	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007002603	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
561007002604	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007002605	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
561007002606	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
561007002607	active site
561007002608	HIGH motif; other site
561007002609	KMSKS motif; other site
561007002610	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
561007002611	tRNA binding surface [nucleotide binding]; other site
561007002612	anticodon binding site; other site
561007002613	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
561007002614	active site
561007002615	Domain of unknown function (DUF348); Region: DUF348; pfam03990
561007002616	Domain of unknown function (DUF348); Region: DUF348; pfam03990
561007002617	Domain of unknown function (DUF348); Region: DUF348; pfam03990
561007002618	G5 domain; Region: G5; pfam07501
561007002619	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
561007002620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007002621	L-asparagine permease; Provisional; Region: PRK15049
561007002622	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
561007002623	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007002624	active site
561007002625	ATP binding site [chemical binding]; other site
561007002626	substrate binding site [chemical binding]; other site
561007002627	activation loop (A-loop); other site
561007002628	Transport protein; Region: actII; TIGR00833
561007002629	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007002630	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007002631	Helix-turn-helix domains; Region: HTH; cl00088
561007002632	Transport protein; Region: actII; TIGR00833
561007002633	Helix-turn-helix domains; Region: HTH; cl00088
561007002634	putative acetyltransferase; Provisional; Region: PRK03624
561007002635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007002636	Coenzyme A binding pocket [chemical binding]; other site
561007002637	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
561007002638	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
561007002639	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
561007002640	AMP-binding enzyme; Region: AMP-binding; cl15778
561007002641	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
561007002642	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
561007002643	dimer interface [polypeptide binding]; other site
561007002644	active site
561007002645	CoA binding pocket [chemical binding]; other site
561007002646	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
561007002647	putative active site [active]
561007002648	catalytic residue [active]
561007002649	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
561007002650	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
561007002651	5S rRNA interface [nucleotide binding]; other site
561007002652	CTC domain interface [polypeptide binding]; other site
561007002653	L16 interface [polypeptide binding]; other site
561007002654	short chain dehydrogenase; Provisional; Region: PRK06197
561007002655	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
561007002656	putative NAD(P) binding site [chemical binding]; other site
561007002657	active site
561007002658	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
561007002659	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
561007002660	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
561007002661	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007002662	active site
561007002663	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
561007002664	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
561007002665	Substrate binding site; other site
561007002666	Mg++ binding site; other site
561007002667	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
561007002668	active site
561007002669	substrate binding site [chemical binding]; other site
561007002670	CoA binding site [chemical binding]; other site
561007002671	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007002672	Helix-turn-helix domains; Region: HTH; cl00088
561007002673	diaminopimelate decarboxylase; Region: lysA; TIGR01048
561007002674	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
561007002675	active site
561007002676	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
561007002677	substrate binding site [chemical binding]; other site
561007002678	catalytic residues [active]
561007002679	dimer interface [polypeptide binding]; other site
561007002680	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
561007002681	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
561007002682	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007002683	ATP binding site [chemical binding]; other site
561007002684	putative Mg++ binding site [ion binding]; other site
561007002685	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007002686	nucleotide binding region [chemical binding]; other site
561007002687	ATP-binding site [chemical binding]; other site
561007002688	TRCF domain; Region: TRCF; cl04088
561007002689	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
561007002690	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
561007002691	homodimer interface [polypeptide binding]; other site
561007002692	metal binding site [ion binding]; metal-binding site
561007002693	Iron permease FTR1 family; Region: FTR1; cl00475
561007002694	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
561007002695	Imelysin; Region: Peptidase_M75; cl09159
561007002696	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
561007002697	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
561007002698	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
561007002699	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007002700	Imelysin; Region: Peptidase_M75; cl09159
561007002701	Iron permease FTR1 family; Region: FTR1; cl00475
561007002702	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
561007002703	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
561007002704	N-acetyl-D-glucosamine binding site [chemical binding]; other site
561007002705	enolase; Provisional; Region: eno; PRK00077
561007002706	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
561007002707	dimer interface [polypeptide binding]; other site
561007002708	metal binding site [ion binding]; metal-binding site
561007002709	substrate binding pocket [chemical binding]; other site
561007002710	Septum formation initiator; Region: DivIC; cl11433
561007002711	Protein of unknown function (DUF501); Region: DUF501; cl00652
561007002712	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
561007002713	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
561007002714	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
561007002715	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
561007002716	AMP-binding enzyme; Region: AMP-binding; cl15778
561007002717	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
561007002718	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
561007002719	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
561007002720	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
561007002721	LGFP repeat; Region: LGFP; pfam08310
561007002722	Cysteine dioxygenase type I; Region: CDO_I; cl15835
561007002723	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
561007002724	active site residue [active]
561007002725	Helix-turn-helix domains; Region: HTH; cl00088
561007002726	enoyl-CoA hydratase; Provisional; Region: PRK05862
561007002727	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007002728	substrate binding site [chemical binding]; other site
561007002729	oxyanion hole (OAH) forming residues; other site
561007002730	trimer interface [polypeptide binding]; other site
561007002731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002732	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
561007002733	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
561007002734	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007002735	substrate binding site [chemical binding]; other site
561007002736	oxyanion hole (OAH) forming residues; other site
561007002737	trimer interface [polypeptide binding]; other site
561007002738	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
561007002739	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007002740	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
561007002741	substrate binding pocket [chemical binding]; other site
561007002742	FAD binding site [chemical binding]; other site
561007002743	catalytic base [active]
561007002744	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
561007002745	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007002746	tetrameric interface [polypeptide binding]; other site
561007002747	NAD binding site [chemical binding]; other site
561007002748	catalytic residues [active]
561007002749	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
561007002750	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
561007002751	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
561007002752	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007002753	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
561007002754	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007002755	dimer interface [polypeptide binding]; other site
561007002756	active site
561007002757	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
561007002758	active site
561007002759	catalytic triad [active]
561007002760	oxyanion hole [active]
561007002761	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007002762	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007002763	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
561007002764	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
561007002765	dimer interface [polypeptide binding]; other site
561007002766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007002767	catalytic residue [active]
561007002768	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
561007002769	RDD family; Region: RDD; cl00746
561007002770	cystathionine gamma-synthase; Provisional; Region: PRK07811
561007002771	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
561007002772	homodimer interface [polypeptide binding]; other site
561007002773	substrate-cofactor binding pocket; other site
561007002774	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007002775	catalytic residue [active]
561007002776	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
561007002777	threonine dehydratase; Provisional; Region: PRK08198
561007002778	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
561007002779	tetramer interface [polypeptide binding]; other site
561007002780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007002781	catalytic residue [active]
561007002782	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
561007002783	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
561007002784	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
561007002785	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
561007002786	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
561007002787	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
561007002788	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
561007002789	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
561007002790	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
561007002791	catalytic residues [active]
561007002792	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007002793	Haemolysin-III related; Region: HlyIII; cl03831
561007002794	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
561007002795	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
561007002796	catalytic residue [active]
561007002797	putative FPP diphosphate  binding site; other site
561007002798	putative FPP binding hydrophobic cleft; other site
561007002799	dimer interface [polypeptide binding]; other site
561007002800	putative IPP diphosphate binding site; other site
561007002801	classical (c) SDRs; Region: SDR_c; cd05233
561007002802	short chain dehydrogenase; Provisional; Region: PRK12939
561007002803	NAD(P) binding site [chemical binding]; other site
561007002804	active site
561007002805	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007002806	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
561007002807	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
561007002808	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007002809	Cytochrome P450; Region: p450; pfam00067
561007002810	classical (c) SDRs; Region: SDR_c; cd05233
561007002811	NAD(P) binding site [chemical binding]; other site
561007002812	active site
561007002813	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007002814	Helix-turn-helix domains; Region: HTH; cl00088
561007002815	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007002816	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
561007002817	NAD binding site [chemical binding]; other site
561007002818	catalytic residues [active]
561007002819	short chain dehydrogenase; Provisional; Region: PRK07774
561007002820	classical (c) SDRs; Region: SDR_c; cd05233
561007002821	NAD(P) binding site [chemical binding]; other site
561007002822	active site
561007002823	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
561007002824	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007002825	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007002826	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
561007002827	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007002828	substrate binding pocket [chemical binding]; other site
561007002829	catalytic triad [active]
561007002830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007002831	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
561007002832	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
561007002833	Walker A/P-loop; other site
561007002834	ATP binding site [chemical binding]; other site
561007002835	Q-loop/lid; other site
561007002836	ABC transporter signature motif; other site
561007002837	Walker B; other site
561007002838	D-loop; other site
561007002839	H-loop/switch region; other site
561007002840	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
561007002841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007002842	NMT1-like family; Region: NMT1_2; cl15260
561007002843	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
561007002844	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007002845	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
561007002846	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
561007002847	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007002848	pantothenate kinase; Provisional; Region: PRK05439
561007002849	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
561007002850	ATP-binding site [chemical binding]; other site
561007002851	CoA-binding site [chemical binding]; other site
561007002852	Mg2+-binding site [ion binding]; other site
561007002853	serine hydroxymethyltransferase; Provisional; Region: PRK13580
561007002854	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
561007002855	dimer interface [polypeptide binding]; other site
561007002856	active site
561007002857	glycine-pyridoxal phosphate binding site [chemical binding]; other site
561007002858	folate binding site [chemical binding]; other site
561007002859	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007002860	dinuclear metal binding motif [ion binding]; other site
561007002861	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
561007002862	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
561007002863	putative active site [active]
561007002864	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007002865	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
561007002866	NodB motif; other site
561007002867	active site
561007002868	catalytic site [active]
561007002869	metal binding site [ion binding]; metal-binding site
561007002870	CsbD-like; Region: CsbD; cl15799
561007002871	Asp23 family; Region: Asp23; cl00574
561007002872	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
561007002873	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007002874	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007002875	fumarate hydratase; Reviewed; Region: fumC; PRK00485
561007002876	Class II fumarases; Region: Fumarase_classII; cd01362
561007002877	active site
561007002878	tetramer interface [polypeptide binding]; other site
561007002879	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
561007002880	putative active site [active]
561007002881	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
561007002882	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
561007002883	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
561007002884	dimer interface [polypeptide binding]; other site
561007002885	active site
561007002886	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
561007002887	substrate binding site [chemical binding]; other site
561007002888	catalytic residue [active]
561007002889	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
561007002890	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
561007002891	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
561007002892	generic binding surface II; other site
561007002893	generic binding surface I; other site
561007002894	LytB protein; Region: LYTB; cl00507
561007002895	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
561007002896	Protein of unknown function (DUF466); Region: DUF466; cl01082
561007002897	carbon starvation protein A; Provisional; Region: PRK15015
561007002898	Carbon starvation protein CstA; Region: CstA; pfam02554
561007002899	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
561007002900	PspC domain; Region: PspC; cl00864
561007002901	Protein of unknown function, DUF488; Region: DUF488; cl01246
561007002902	GTP-binding protein YchF; Reviewed; Region: PRK09601
561007002903	YchF GTPase; Region: YchF; cd01900
561007002904	G1 box; other site
561007002905	GTP/Mg2+ binding site [chemical binding]; other site
561007002906	Switch I region; other site
561007002907	G2 box; other site
561007002908	Switch II region; other site
561007002909	G3 box; other site
561007002910	G4 box; other site
561007002911	G5 box; other site
561007002912	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
561007002913	Bacterial PH domain; Region: DUF304; cl01348
561007002914	Predicted membrane protein [Function unknown]; Region: COG3428
561007002915	Bacterial PH domain; Region: DUF304; cl01348
561007002916	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
561007002917	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007002918	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007002919	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007002920	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
561007002921	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
561007002922	dimer interface [polypeptide binding]; other site
561007002923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007002924	catalytic residue [active]
561007002925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007002926	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007002927	putative substrate translocation pore; other site
561007002928	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
561007002929	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
561007002930	ABC transporter; Region: ABC_tran_2; pfam12848
561007002931	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
561007002932	DoxX; Region: DoxX; cl00976
561007002933	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
561007002934	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
561007002935	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
561007002936	dimer interface [polypeptide binding]; other site
561007002937	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007002938	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
561007002939	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007002940	Helix-turn-helix domains; Region: HTH; cl00088
561007002941	WHG domain; Region: WHG; pfam13305
561007002942	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007002943	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
561007002944	dimer interface [polypeptide binding]; other site
561007002945	catalytic triad [active]
561007002946	peroxidatic and resolving cysteines [active]
561007002947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007002948	S-adenosylmethionine binding site [chemical binding]; other site
561007002949	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007002950	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
561007002951	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007002952	Methyltransferase domain; Region: Methyltransf_31; pfam13847
561007002953	S-adenosylmethionine binding site [chemical binding]; other site
561007002954	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007002955	Acyltransferase family; Region: Acyl_transf_3; pfam01757
561007002956	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007002957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
561007002958	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
561007002959	minor groove reading motif; other site
561007002960	helix-hairpin-helix signature motif; other site
561007002961	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
561007002962	short chain dehydrogenase; Validated; Region: PRK06182
561007002963	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
561007002964	NADP binding site [chemical binding]; other site
561007002965	active site
561007002966	steroid binding site; other site
561007002967	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
561007002968	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
561007002969	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
561007002970	putative active site [active]
561007002971	putative substrate binding site [chemical binding]; other site
561007002972	putative cosubstrate binding site; other site
561007002973	catalytic site [active]
561007002974	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
561007002975	aromatic arch; other site
561007002976	DCoH dimer interaction site [polypeptide binding]; other site
561007002977	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
561007002978	DCoH tetramer interaction site [polypeptide binding]; other site
561007002979	substrate binding site [chemical binding]; other site
561007002980	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
561007002981	active site
561007002982	8-oxo-dGMP binding site [chemical binding]; other site
561007002983	nudix motif; other site
561007002984	metal binding site [ion binding]; metal-binding site
561007002985	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
561007002986	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
561007002987	G1 box; other site
561007002988	putative GEF interaction site [polypeptide binding]; other site
561007002989	GTP/Mg2+ binding site [chemical binding]; other site
561007002990	Switch I region; other site
561007002991	G2 box; other site
561007002992	G3 box; other site
561007002993	Switch II region; other site
561007002994	G4 box; other site
561007002995	G5 box; other site
561007002996	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
561007002997	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
561007002998	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
561007002999	active site
561007003000	metal binding site [ion binding]; metal-binding site
561007003001	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
561007003002	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007003003	SCP-2 sterol transfer family; Region: SCP2; cl01225
561007003004	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007003005	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007003006	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
561007003007	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
561007003008	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
561007003009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007003010	FO synthase; Reviewed; Region: fbiC; PRK09234
561007003011	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007003012	FeS/SAM binding site; other site
561007003013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007003014	FeS/SAM binding site; other site
561007003015	Excalibur calcium-binding domain; Region: Excalibur; cl05460
561007003016	MspA; Region: MspA; pfam09203
561007003017	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
561007003018	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
561007003019	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
561007003020	active site
561007003021	FMN binding site [chemical binding]; other site
561007003022	2,4-decadienoyl-CoA binding site; other site
561007003023	catalytic residue [active]
561007003024	4Fe-4S cluster binding site [ion binding]; other site
561007003025	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003026	Helix-turn-helix domains; Region: HTH; cl00088
561007003027	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
561007003028	Ferredoxin [Energy production and conversion]; Region: COG1146
561007003029	4Fe-4S binding domain; Region: Fer4; cl02805
561007003030	succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539
561007003031	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007003032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007003033	homodimer interface [polypeptide binding]; other site
561007003034	catalytic residue [active]
561007003035	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
561007003036	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
561007003037	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
561007003038	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007003039	Glutamate binding site [chemical binding]; other site
561007003040	NAD binding site [chemical binding]; other site
561007003041	catalytic residues [active]
561007003042	Proline dehydrogenase; Region: Pro_dh; cl03282
561007003043	acyl-CoA synthetase; Validated; Region: PRK07787
561007003044	AMP-binding enzyme; Region: AMP-binding; cl15778
561007003045	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007003046	DinB superfamily; Region: DinB_2; pfam12867
561007003047	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
561007003048	active site
561007003049	catalytic triad [active]
561007003050	oxyanion hole [active]
561007003051	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
561007003052	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
561007003053	putative trimer interface [polypeptide binding]; other site
561007003054	putative CoA binding site [chemical binding]; other site
561007003055	succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900
561007003056	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
561007003057	metal binding site [ion binding]; metal-binding site
561007003058	putative dimer interface [polypeptide binding]; other site
561007003059	Cupin domain; Region: Cupin_2; cl09118
561007003060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007003061	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007003062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007003063	putative substrate translocation pore; other site
561007003064	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
561007003065	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
561007003066	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
561007003067	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
561007003068	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
561007003069	AMP-binding enzyme; Region: AMP-binding; cl15778
561007003070	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
561007003071	extended (e) SDRs; Region: SDR_e; cd08946
561007003072	NAD(P) binding site [chemical binding]; other site
561007003073	active site
561007003074	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
561007003075	dihydropteroate synthase; Region: DHPS; TIGR01496
561007003076	substrate binding pocket [chemical binding]; other site
561007003077	dimer interface [polypeptide binding]; other site
561007003078	inhibitor binding site; inhibition site
561007003079	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
561007003080	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
561007003081	active site
561007003082	DivIVA domain; Region: DivI1A_domain; TIGR03544
561007003083	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
561007003084	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
561007003085	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
561007003086	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
561007003087	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
561007003088	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
561007003089	ligand binding site; other site
561007003090	oligomer interface; other site
561007003091	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
561007003092	dimer interface [polypeptide binding]; other site
561007003093	N-terminal domain interface [polypeptide binding]; other site
561007003094	sulfate 1 binding site; other site
561007003095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007003096	DNA-binding site [nucleotide binding]; DNA binding site
561007003097	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007003098	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007003099	homodimer interface [polypeptide binding]; other site
561007003100	catalytic residue [active]
561007003101	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007003102	Phospholipid methyltransferase; Region: PEMT; cl00763
561007003103	ABC-2 type transporter; Region: ABC2_membrane; cl11417
561007003104	ABC-2 type transporter; Region: ABC2_membrane; cl11417
561007003105	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
561007003106	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
561007003107	Walker A/P-loop; other site
561007003108	ATP binding site [chemical binding]; other site
561007003109	Q-loop/lid; other site
561007003110	ABC transporter signature motif; other site
561007003111	Walker B; other site
561007003112	D-loop; other site
561007003113	H-loop/switch region; other site
561007003114	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007003115	Helix-turn-helix domains; Region: HTH; cl00088
561007003116	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
561007003117	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007003118	S-adenosylmethionine binding site [chemical binding]; other site
561007003119	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
561007003120	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007003121	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007003122	DNA binding residues [nucleotide binding]
561007003123	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
561007003124	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
561007003125	protein binding site [polypeptide binding]; other site
561007003126	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
561007003127	Domain of unknown function DUF59; Region: DUF59; cl00941
561007003128	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
561007003129	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
561007003130	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
561007003131	N-acetyl-D-glucosamine binding site [chemical binding]; other site
561007003132	catalytic residue [active]
561007003133	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007003134	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
561007003135	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007003136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007003137	putative PBP binding loops; other site
561007003138	dimer interface [polypeptide binding]; other site
561007003139	ABC-ATPase subunit interface; other site
561007003140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007003141	dimer interface [polypeptide binding]; other site
561007003142	conserved gate region; other site
561007003143	putative PBP binding loops; other site
561007003144	ABC-ATPase subunit interface; other site
561007003145	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
561007003146	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
561007003147	Walker A/P-loop; other site
561007003148	ATP binding site [chemical binding]; other site
561007003149	Q-loop/lid; other site
561007003150	ABC transporter signature motif; other site
561007003151	Walker B; other site
561007003152	D-loop; other site
561007003153	H-loop/switch region; other site
561007003154	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
561007003155	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
561007003156	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
561007003157	Helix-turn-helix domains; Region: HTH; cl00088
561007003158	short chain dehydrogenase; Provisional; Region: PRK07825
561007003159	classical (c) SDRs; Region: SDR_c; cd05233
561007003160	NAD(P) binding site [chemical binding]; other site
561007003161	active site
561007003162	short chain dehydrogenase; Provisional; Region: PRK07832
561007003163	classical (c) SDRs; Region: SDR_c; cd05233
561007003164	NAD(P) binding site [chemical binding]; other site
561007003165	active site
561007003166	MarC family integral membrane protein; Region: MarC; cl00919
561007003167	Malic enzyme, N-terminal domain; Region: malic; pfam00390
561007003168	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
561007003169	putative NAD(P) binding site [chemical binding]; other site
561007003170	NMT1-like family; Region: NMT1_2; cl15260
561007003171	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
561007003172	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007003173	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007003174	hypothetical protein; Provisional; Region: PRK06194
561007003175	classical (c) SDRs; Region: SDR_c; cd05233
561007003176	NAD(P) binding site [chemical binding]; other site
561007003177	active site
561007003178	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
561007003179	classical (c) SDRs; Region: SDR_c; cd05233
561007003180	NAD(P) binding site [chemical binding]; other site
561007003181	active site
561007003182	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
561007003183	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007003184	S-adenosylmethionine binding site [chemical binding]; other site
561007003185	Helix-turn-helix domains; Region: HTH; cl00088
561007003186	Secretory lipase; Region: LIP; pfam03583
561007003187	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
561007003188	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
561007003189	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
561007003190	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
561007003191	TPP-binding site [chemical binding]; other site
561007003192	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
561007003193	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
561007003194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
561007003195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007003196	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007003197	putative substrate translocation pore; other site
561007003198	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
561007003199	FAD binding domain; Region: FAD_binding_4; pfam01565
561007003200	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
561007003201	active site
561007003202	Helix-turn-helix domains; Region: HTH; cl00088
561007003203	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
561007003204	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
561007003205	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
561007003206	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
561007003207	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003208	Family description; Region: UvrD_C_2; cl15862
561007003209	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
561007003210	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
561007003211	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
561007003212	ATP binding site [chemical binding]; other site
561007003213	Mg++ binding site [ion binding]; other site
561007003214	motif III; other site
561007003215	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007003216	nucleotide binding region [chemical binding]; other site
561007003217	ATP-binding site [chemical binding]; other site
561007003218	DbpA RNA binding domain; Region: DbpA; pfam03880
561007003219	OpgC protein; Region: OpgC_C; cl00792
561007003220	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007003221	FAD binding domain; Region: FAD_binding_4; pfam01565
561007003222	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
561007003223	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
561007003224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003225	NAD(P) binding site [chemical binding]; other site
561007003226	active site
561007003227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007003228	H+ Antiporter protein; Region: 2A0121; TIGR00900
561007003229	putative substrate translocation pore; other site
561007003230	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
561007003231	HIT family signature motif; other site
561007003232	catalytic residue [active]
561007003233	Mechanosensitive ion channel; Region: MS_channel; pfam00924
561007003234	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
561007003235	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
561007003236	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
561007003237	Walker A/P-loop; other site
561007003238	ATP binding site [chemical binding]; other site
561007003239	Q-loop/lid; other site
561007003240	ABC transporter signature motif; other site
561007003241	Walker B; other site
561007003242	D-loop; other site
561007003243	H-loop/switch region; other site
561007003244	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
561007003245	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
561007003246	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003247	Walker A/P-loop; other site
561007003248	ATP binding site [chemical binding]; other site
561007003249	Q-loop/lid; other site
561007003250	ABC transporter signature motif; other site
561007003251	Walker B; other site
561007003252	D-loop; other site
561007003253	H-loop/switch region; other site
561007003254	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007003255	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007003256	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007003257	catalytic core [active]
561007003258	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
561007003259	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
561007003260	active site
561007003261	metal binding site [ion binding]; metal-binding site
561007003262	DNA binding site [nucleotide binding]
561007003263	AAA ATPase domain; Region: AAA_15; pfam13175
561007003264	Uncharacterized conserved protein [Function unknown]; Region: COG4717
561007003265	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
561007003266	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007003267	active site
561007003268	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
561007003269	Helix-turn-helix domains; Region: HTH; cl00088
561007003270	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007003271	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007003272	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
561007003273	putative active site [active]
561007003274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007003275	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007003276	putative substrate translocation pore; other site
561007003277	tetracycline repressor protein TetR; Provisional; Region: PRK13756
561007003278	Helix-turn-helix domains; Region: HTH; cl00088
561007003279	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
561007003280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003281	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
561007003282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003283	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
561007003284	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
561007003285	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
561007003286	active site
561007003287	HIGH motif; other site
561007003288	KMSK motif region; other site
561007003289	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
561007003290	tRNA binding surface [nucleotide binding]; other site
561007003291	anticodon binding site; other site
561007003292	diaminopimelate decarboxylase; Region: lysA; TIGR01048
561007003293	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
561007003294	active site
561007003295	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
561007003296	substrate binding site [chemical binding]; other site
561007003297	catalytic residues [active]
561007003298	dimer interface [polypeptide binding]; other site
561007003299	homoserine dehydrogenase; Provisional; Region: PRK06349
561007003300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003301	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
561007003302	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
561007003303	threonine synthase; Reviewed; Region: PRK06721
561007003304	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
561007003305	homodimer interface [polypeptide binding]; other site
561007003306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007003307	catalytic residue [active]
561007003308	homoserine kinase; Provisional; Region: PRK01212
561007003309	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
561007003310	transcription termination factor Rho; Provisional; Region: PRK12608
561007003311	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
561007003312	RNA binding site [nucleotide binding]; other site
561007003313	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
561007003314	multimer interface [polypeptide binding]; other site
561007003315	Walker A motif; other site
561007003316	ATP binding site [chemical binding]; other site
561007003317	Walker B motif; other site
561007003318	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
561007003319	peptide chain release factor 1; Validated; Region: prfA; PRK00591
561007003320	RF-1 domain; Region: RF-1; cl02875
561007003321	RF-1 domain; Region: RF-1; cl02875
561007003322	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
561007003323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007003324	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
561007003325	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
561007003326	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
561007003327	Mg++ binding site [ion binding]; other site
561007003328	putative catalytic motif [active]
561007003329	substrate binding site [chemical binding]; other site
561007003330	ATP synthase A chain; Region: ATP-synt_A; cl00413
561007003331	ATP synthase subunit C; Region: ATP-synt_C; cl00466
561007003332	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
561007003333	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
561007003334	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
561007003335	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
561007003336	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
561007003337	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
561007003338	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
561007003339	beta subunit interaction interface [polypeptide binding]; other site
561007003340	Walker A motif; other site
561007003341	ATP binding site [chemical binding]; other site
561007003342	Walker B motif; other site
561007003343	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
561007003344	ATP synthase; Region: ATP-synt; cl00365
561007003345	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
561007003346	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
561007003347	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
561007003348	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
561007003349	alpha subunit interaction interface [polypeptide binding]; other site
561007003350	Walker A motif; other site
561007003351	ATP binding site [chemical binding]; other site
561007003352	Walker B motif; other site
561007003353	inhibitor binding site; inhibition site
561007003354	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
561007003355	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
561007003356	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
561007003357	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
561007003358	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
561007003359	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
561007003360	hinge; other site
561007003361	active site
561007003362	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
561007003363	dimerization interface [polypeptide binding]; other site
561007003364	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
561007003365	cyclase homology domain; Region: CHD; cd07302
561007003366	nucleotidyl binding site; other site
561007003367	metal binding site [ion binding]; metal-binding site
561007003368	dimer interface [polypeptide binding]; other site
561007003369	Protein of unknown function DUF91; Region: DUF91; cl00709
561007003370	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
561007003371	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007003372	dimer interface [polypeptide binding]; other site
561007003373	substrate binding site [chemical binding]; other site
561007003374	metal binding site [ion binding]; metal-binding site
561007003375	putative acyltransferase; Provisional; Region: PRK05790
561007003376	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007003377	dimer interface [polypeptide binding]; other site
561007003378	active site
561007003379	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
561007003380	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
561007003381	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007003382	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
561007003383	glycogen branching enzyme; Provisional; Region: PRK05402
561007003384	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
561007003385	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
561007003386	active site
561007003387	catalytic site [active]
561007003388	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
561007003389	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
561007003390	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
561007003391	active site
561007003392	homodimer interface [polypeptide binding]; other site
561007003393	catalytic site [active]
561007003394	acceptor binding site [chemical binding]; other site
561007003395	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
561007003396	putative homodimer interface [polypeptide binding]; other site
561007003397	putative active site pocket [active]
561007003398	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
561007003399	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
561007003400	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
561007003401	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003402	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003403	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
561007003404	Isochorismatase family; Region: Isochorismatase; pfam00857
561007003405	catalytic triad [active]
561007003406	metal binding site [ion binding]; metal-binding site
561007003407	conserved cis-peptide bond; other site
561007003408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007003409	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
561007003410	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
561007003411	active site
561007003412	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
561007003413	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
561007003414	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
561007003415	putative active site pocket [active]
561007003416	cleavage site
561007003417	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
561007003418	MPN+ (JAMM) motif; other site
561007003419	Zinc-binding site [ion binding]; other site
561007003420	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
561007003421	MoaE interaction surface [polypeptide binding]; other site
561007003422	MoeB interaction surface [polypeptide binding]; other site
561007003423	thiocarboxylated glycine; other site
561007003424	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
561007003425	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
561007003426	dimer interface [polypeptide binding]; other site
561007003427	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007003428	catalytic residue [active]
561007003429	Rhomboid family; Region: Rhomboid; cl11446
561007003430	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
561007003431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007003432	ribonuclease PH; Reviewed; Region: rph; PRK00173
561007003433	Ribonuclease PH; Region: RNase_PH_bact; cd11362
561007003434	hexamer interface [polypeptide binding]; other site
561007003435	active site
561007003436	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
561007003437	active site
561007003438	dimerization interface [polypeptide binding]; other site
561007003439	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007003440	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
561007003441	putative NAD(P) binding site [chemical binding]; other site
561007003442	Domain of unknown function (DUF3817); Region: DUF3817; cl14844
561007003443	Glucitol operon activator protein (GutM); Region: GutM; cl01890
561007003444	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
561007003445	AMP-binding enzyme; Region: AMP-binding; cl15778
561007003446	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
561007003447	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
561007003448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
561007003449	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003450	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
561007003451	enoyl-CoA hydratase; Provisional; Region: PRK06563
561007003452	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007003453	substrate binding site [chemical binding]; other site
561007003454	oxyanion hole (OAH) forming residues; other site
561007003455	trimer interface [polypeptide binding]; other site
561007003456	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007003457	Helix-turn-helix domains; Region: HTH; cl00088
561007003458	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
561007003459	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
561007003460	molybdopterin cofactor binding site; other site
561007003461	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
561007003462	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
561007003463	putative molybdopterin cofactor binding site; other site
561007003464	hypothetical protein; Provisional; Region: PRK06184
561007003465	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003466	Helix-turn-helix domains; Region: HTH; cl00088
561007003467	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
561007003468	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007003469	DNA-binding site [nucleotide binding]; DNA binding site
561007003470	UTRA domain; Region: UTRA; cl01230
561007003471	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
561007003472	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
561007003473	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007003474	motif II; other site
561007003475	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
561007003476	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007003477	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
561007003478	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003479	Walker A/P-loop; other site
561007003480	ATP binding site [chemical binding]; other site
561007003481	Q-loop/lid; other site
561007003482	ABC transporter signature motif; other site
561007003483	Walker B; other site
561007003484	D-loop; other site
561007003485	H-loop/switch region; other site
561007003486	TOBE domain; Region: TOBE_2; cl01440
561007003487	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
561007003488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007003489	dimer interface [polypeptide binding]; other site
561007003490	conserved gate region; other site
561007003491	putative PBP binding loops; other site
561007003492	ABC-ATPase subunit interface; other site
561007003493	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007003494	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
561007003495	putative active site [active]
561007003496	putative catalytic site [active]
561007003497	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007003498	tetracycline repressor protein TetR; Provisional; Region: PRK13756
561007003499	Helix-turn-helix domains; Region: HTH; cl00088
561007003500	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
561007003501	Predicted membrane protein [Function unknown]; Region: COG4425
561007003502	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
561007003503	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007003504	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
561007003505	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
561007003506	active site
561007003507	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007003508	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
561007003509	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
561007003510	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
561007003511	phosphate binding site [ion binding]; other site
561007003512	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
561007003513	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
561007003514	putative active site [active]
561007003515	putative catalytic site [active]
561007003516	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007003517	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
561007003518	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
561007003519	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
561007003520	putative NAD(P) binding site [chemical binding]; other site
561007003521	active site
561007003522	'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828
561007003523	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
561007003524	active site
561007003525	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
561007003526	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
561007003527	nudix motif; other site
561007003528	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
561007003529	catalytic triad [active]
561007003530	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
561007003531	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007003532	Helix-turn-helix domains; Region: HTH; cl00088
561007003533	tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152
561007003534	Transport protein; Region: actII; TIGR00833
561007003535	Histidine kinase; Region: HisKA_3; pfam07730
561007003536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
561007003537	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
561007003538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007003539	active site
561007003540	phosphorylation site [posttranslational modification]
561007003541	intermolecular recognition site; other site
561007003542	dimerization interface [polypeptide binding]; other site
561007003543	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007003544	DNA binding residues [nucleotide binding]
561007003545	dimerization interface [polypeptide binding]; other site
561007003546	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
561007003547	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
561007003548	MgtE intracellular N domain; Region: MgtE_N; cl15244
561007003549	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
561007003550	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007003551	Helix-turn-helix domains; Region: HTH; cl00088
561007003552	short chain dehydrogenase; Provisional; Region: PRK07825
561007003553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003554	NAD(P) binding site [chemical binding]; other site
561007003555	active site
561007003556	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007003557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003559	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
561007003560	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
561007003561	active site
561007003562	catalytic tetrad [active]
561007003563	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007003564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
561007003565	Bacterial Ig-like domain; Region: Big_5; cl01012
561007003566	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
561007003567	DivIVA protein; Region: DivIVA; pfam05103
561007003568	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
561007003569	catalytic site [active]
561007003570	putative active site [active]
561007003571	putative substrate binding site [chemical binding]; other site
561007003572	dimer interface [polypeptide binding]; other site
561007003573	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
561007003574	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007003575	Helix-turn-helix domains; Region: HTH; cl00088
561007003576	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
561007003577	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003578	NAD(P) binding site [chemical binding]; other site
561007003579	active site
561007003580	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
561007003581	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007003582	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007003583	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
561007003584	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
561007003585	Cutinase; Region: Cutinase; pfam01083
561007003586	Amino acid permease; Region: AA_permease_2; pfam13520
561007003587	Protein of unknown function (DUF732); Region: DUF732; pfam05305
561007003588	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
561007003589	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
561007003590	CysD dimerization site [polypeptide binding]; other site
561007003591	G1 box; other site
561007003592	putative GEF interaction site [polypeptide binding]; other site
561007003593	GTP/Mg2+ binding site [chemical binding]; other site
561007003594	Switch I region; other site
561007003595	G2 box; other site
561007003596	G3 box; other site
561007003597	Switch II region; other site
561007003598	G4 box; other site
561007003599	G5 box; other site
561007003600	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
561007003601	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
561007003602	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
561007003603	ligand-binding site [chemical binding]; other site
561007003604	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
561007003605	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
561007003606	Active Sites [active]
561007003607	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
561007003608	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
561007003609	Sulfatase; Region: Sulfatase; cl10460
561007003610	Predicted ATPase [General function prediction only]; Region: COG4637
561007003611	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
561007003612	Walker A/P-loop; other site
561007003613	ATP binding site [chemical binding]; other site
561007003614	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
561007003615	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
561007003616	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
561007003617	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
561007003618	RNA binding site [nucleotide binding]; other site
561007003619	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007003620	Helix-turn-helix domains; Region: HTH; cl00088
561007003621	Protein of unknown function (DUF732); Region: DUF732; pfam05305
561007003622	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
561007003623	ligand binding site [chemical binding]; other site
561007003624	flexible hinge region; other site
561007003625	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
561007003626	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007003627	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
561007003628	Copper resistance protein D; Region: CopD; cl00563
561007003629	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
561007003630	allophanate hydrolase; Provisional; Region: PRK08186
561007003631	Amidase; Region: Amidase; cl11426
561007003632	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
561007003633	dimer interface [polypeptide binding]; other site
561007003634	ssDNA binding site [nucleotide binding]; other site
561007003635	tetramer (dimer of dimers) interface [polypeptide binding]; other site
561007003636	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
561007003637	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003638	Walker A/P-loop; other site
561007003639	ATP binding site [chemical binding]; other site
561007003640	Q-loop/lid; other site
561007003641	ABC transporter signature motif; other site
561007003642	Walker B; other site
561007003643	D-loop; other site
561007003644	H-loop/switch region; other site
561007003645	ABC transporter; Region: ABC_tran_2; pfam12848
561007003646	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
561007003647	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
561007003648	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
561007003649	active site
561007003650	Pirin-related protein [General function prediction only]; Region: COG1741
561007003651	Cupin domain; Region: Cupin_2; cl09118
561007003652	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
561007003653	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
561007003654	active site
561007003655	catalytic site [active]
561007003656	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
561007003657	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
561007003658	apolar tunnel; other site
561007003659	heme binding site [chemical binding]; other site
561007003660	dimerization interface [polypeptide binding]; other site
561007003661	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
561007003662	active site
561007003663	Repair protein; Region: Repair_PSII; cl01535
561007003664	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
561007003665	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
561007003666	Zn binding site [ion binding]; other site
561007003667	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
561007003668	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007003669	Peptidase family M48; Region: Peptidase_M48; cl12018
561007003670	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
561007003671	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
561007003672	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
561007003673	putative DNA binding site [nucleotide binding]; other site
561007003674	catalytic residue [active]
561007003675	putative H2TH interface [polypeptide binding]; other site
561007003676	putative catalytic residues [active]
561007003677	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
561007003678	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
561007003679	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007003680	Helix-turn-helix domains; Region: HTH; cl00088
561007003681	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007003682	Helix-turn-helix domains; Region: HTH; cl00088
561007003683	Predicted esterase [General function prediction only]; Region: COG0627
561007003684	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007003685	trigger factor; Provisional; Region: tig; PRK01490
561007003686	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
561007003687	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
561007003688	Clp protease; Region: CLP_protease; pfam00574
561007003689	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
561007003690	oligomer interface [polypeptide binding]; other site
561007003691	active site residues [active]
561007003692	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
561007003693	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
561007003694	oligomer interface [polypeptide binding]; other site
561007003695	active site residues [active]
561007003696	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
561007003697	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
561007003698	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007003699	Walker A motif; other site
561007003700	ATP binding site [chemical binding]; other site
561007003701	Walker B motif; other site
561007003702	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
561007003703	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
561007003704	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007003705	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
561007003706	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007003707	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
561007003708	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
561007003709	putative di-iron ligands [ion binding]; other site
561007003710	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
561007003711	FAD binding pocket [chemical binding]; other site
561007003712	FAD binding motif [chemical binding]; other site
561007003713	phosphate binding motif [ion binding]; other site
561007003714	beta-alpha-beta structure motif; other site
561007003715	NAD binding pocket [chemical binding]; other site
561007003716	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
561007003717	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
561007003718	Helix-turn-helix domains; Region: HTH; cl00088
561007003719	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
561007003720	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
561007003721	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
561007003722	putative molybdopterin cofactor binding site [chemical binding]; other site
561007003723	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
561007003724	putative molybdopterin cofactor binding site; other site
561007003725	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
561007003726	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
561007003727	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
561007003728	dimer interface [polypeptide binding]; other site
561007003729	PYR/PP interface [polypeptide binding]; other site
561007003730	TPP binding site [chemical binding]; other site
561007003731	substrate binding site [chemical binding]; other site
561007003732	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
561007003733	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
561007003734	TPP-binding site [chemical binding]; other site
561007003735	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
561007003736	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
561007003737	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
561007003738	GTP binding site; other site
561007003739	YibE/F-like protein; Region: YibE_F; cl02259
561007003740	hypothetical protein; Provisional; Region: PRK06753
561007003741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003742	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
561007003743	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
561007003744	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
561007003745	active site
561007003746	HIGH motif; other site
561007003747	nucleotide binding site [chemical binding]; other site
561007003748	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
561007003749	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
561007003750	active site
561007003751	KMSKS motif; other site
561007003752	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
561007003753	tRNA binding surface [nucleotide binding]; other site
561007003754	anticodon binding site; other site
561007003755	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
561007003756	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
561007003757	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
561007003758	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
561007003759	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
561007003760	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
561007003761	active site
561007003762	multimer interface [polypeptide binding]; other site
561007003763	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
561007003764	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
561007003765	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
561007003766	homodimer interface [polypeptide binding]; other site
561007003767	oligonucleotide binding site [chemical binding]; other site
561007003768	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
561007003769	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
561007003770	GTPase CgtA; Reviewed; Region: obgE; PRK12296
561007003771	GTP1/OBG; Region: GTP1_OBG; pfam01018
561007003772	Obg GTPase; Region: Obg; cd01898
561007003773	G1 box; other site
561007003774	GTP/Mg2+ binding site [chemical binding]; other site
561007003775	Switch I region; other site
561007003776	G2 box; other site
561007003777	G3 box; other site
561007003778	Switch II region; other site
561007003779	G4 box; other site
561007003780	G5 box; other site
561007003781	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
561007003782	gamma-glutamyl kinase; Provisional; Region: PRK05429
561007003783	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
561007003784	nucleotide binding site [chemical binding]; other site
561007003785	homotetrameric interface [polypeptide binding]; other site
561007003786	putative phosphate binding site [ion binding]; other site
561007003787	putative allosteric binding site; other site
561007003788	PUA domain; Region: PUA; cl00607
561007003789	N-terminal domain of eIF2D, malignant T cell-amplified sequence 1 and related proteins; Region: eIF2D_N_like; cl16921
561007003790	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
561007003791	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
561007003792	substrate binding site [chemical binding]; other site
561007003793	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
561007003794	dimer interface [polypeptide binding]; other site
561007003795	ATP binding site [chemical binding]; other site
561007003796	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
561007003797	putative catalytic cysteine [active]
561007003798	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
561007003799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007003800	Walker A motif; other site
561007003801	ATP binding site [chemical binding]; other site
561007003802	Walker B motif; other site
561007003803	arginine finger; other site
561007003804	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
561007003805	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007003806	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
561007003807	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
561007003808	active site
561007003809	(T/H)XGH motif; other site
561007003810	Oligomerisation domain; Region: Oligomerisation; cl00519
561007003811	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007003812	catalytic core [active]
561007003813	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
561007003814	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
561007003815	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
561007003816	Competence protein; Region: Competence; cl00471
561007003817	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
561007003818	hypothetical protein; Reviewed; Region: PRK07914
561007003819	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
561007003820	Uncharacterized conserved protein [Function unknown]; Region: COG2308
561007003821	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
561007003822	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
561007003823	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
561007003824	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
561007003825	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
561007003826	Helix-turn-helix domains; Region: HTH; cl00088
561007003827	PemK-like protein; Region: PemK; cl00995
561007003828	GTP-binding protein LepA; Provisional; Region: PRK05433
561007003829	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
561007003830	G1 box; other site
561007003831	putative GEF interaction site [polypeptide binding]; other site
561007003832	GTP/Mg2+ binding site [chemical binding]; other site
561007003833	Switch I region; other site
561007003834	G2 box; other site
561007003835	G3 box; other site
561007003836	Switch II region; other site
561007003837	G4 box; other site
561007003838	G5 box; other site
561007003839	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
561007003840	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
561007003841	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
561007003842	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
561007003843	Nitronate monooxygenase; Region: NMO; pfam03060
561007003844	FMN binding site [chemical binding]; other site
561007003845	substrate binding site [chemical binding]; other site
561007003846	putative catalytic residue [active]
561007003847	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
561007003848	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
561007003849	hypothetical protein; Provisional; Region: PRK06185
561007003850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003851	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007003852	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
561007003853	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
561007003854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007003855	dimer interface [polypeptide binding]; other site
561007003856	conserved gate region; other site
561007003857	putative PBP binding loops; other site
561007003858	ABC-ATPase subunit interface; other site
561007003859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007003860	dimer interface [polypeptide binding]; other site
561007003861	conserved gate region; other site
561007003862	putative PBP binding loops; other site
561007003863	ABC-ATPase subunit interface; other site
561007003864	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
561007003865	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
561007003866	Walker A/P-loop; other site
561007003867	ATP binding site [chemical binding]; other site
561007003868	Q-loop/lid; other site
561007003869	ABC transporter signature motif; other site
561007003870	Walker B; other site
561007003871	D-loop; other site
561007003872	H-loop/switch region; other site
561007003873	TOBE-like domain; Region: TOBE_3; pfam12857
561007003874	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
561007003875	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
561007003876	putative active site [active]
561007003877	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
561007003878	putative active site [active]
561007003879	sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
561007003880	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
561007003881	CysD dimerization site [polypeptide binding]; other site
561007003882	G1 box; other site
561007003883	putative GEF interaction site [polypeptide binding]; other site
561007003884	GTP/Mg2+ binding site [chemical binding]; other site
561007003885	Switch I region; other site
561007003886	G2 box; other site
561007003887	G3 box; other site
561007003888	Switch II region; other site
561007003889	G4 box; other site
561007003890	G5 box; other site
561007003891	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
561007003892	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
561007003893	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
561007003894	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
561007003895	Active Sites [active]
561007003896	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
561007003897	Active Sites [active]
561007003898	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
561007003899	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
561007003900	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
561007003901	coproporphyrinogen III oxidase; Validated; Region: PRK05628
561007003902	HemN C-terminal domain; Region: HemN_C; pfam06969
561007003903	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270
561007003904	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
561007003905	Helix-turn-helix domains; Region: HTH; cl00088
561007003906	chaperone protein DnaJ; Provisional; Region: PRK14278
561007003907	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
561007003908	HSP70 interaction site [polypeptide binding]; other site
561007003909	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
561007003910	Zn binding sites [ion binding]; other site
561007003911	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
561007003912	dimer interface [polypeptide binding]; other site
561007003913	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
561007003914	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
561007003915	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
561007003916	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
561007003917	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007003918	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
561007003919	Domain of unknown function DUF21; Region: DUF21; pfam01595
561007003920	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
561007003921	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
561007003922	Transporter associated domain; Region: CorC_HlyC; cl08393
561007003923	enolase; Provisional; Region: eno; PRK00077
561007003924	GTPase Era; Reviewed; Region: era; PRK00089
561007003925	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
561007003926	G1 box; other site
561007003927	GTP/Mg2+ binding site [chemical binding]; other site
561007003928	Switch I region; other site
561007003929	G2 box; other site
561007003930	Switch II region; other site
561007003931	G3 box; other site
561007003932	G4 box; other site
561007003933	G5 box; other site
561007003934	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
561007003935	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
561007003936	amidase; Provisional; Region: PRK06061
561007003937	Amidase; Region: Amidase; cl11426
561007003938	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
561007003939	Recombination protein O N terminal; Region: RecO_N; cl15812
561007003940	Recombination protein O C terminal; Region: RecO_C; pfam02565
561007003941	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
561007003942	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
561007003943	catalytic residue [active]
561007003944	putative FPP diphosphate  binding site; other site
561007003945	putative FPP binding hydrophobic cleft; other site
561007003946	dimer interface [polypeptide binding]; other site
561007003947	putative IPP diphosphate binding site; other site
561007003948	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
561007003949	metal binding site 2 [ion binding]; metal-binding site
561007003950	putative DNA binding helix; other site
561007003951	metal binding site 1 [ion binding]; metal-binding site
561007003952	dimer interface [polypeptide binding]; other site
561007003953	structural Zn2+ binding site [ion binding]; other site
561007003954	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007003955	dimerization interface [polypeptide binding]; other site
561007003956	putative DNA binding site [nucleotide binding]; other site
561007003957	putative Zn2+ binding site [ion binding]; other site
561007003958	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
561007003959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007003960	NAD(P) binding site [chemical binding]; other site
561007003961	active site
561007003962	Fatty acid desaturase; Region: FA_desaturase; pfam00487
561007003963	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
561007003964	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007003965	2,4-diaminobutyrate 4-transaminases; Region: dat; TIGR00709
561007003966	inhibitor-cofactor binding pocket; inhibition site
561007003967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007003968	catalytic residue [active]
561007003969	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
561007003970	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007003971	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007003972	catalytic residue [active]
561007003973	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007003974	hydrophobic ligand binding site; other site
561007003975	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
561007003976	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263
561007003977	Walker A/P-loop; other site
561007003978	ATP binding site [chemical binding]; other site
561007003979	Q-loop/lid; other site
561007003980	ABC transporter signature motif; other site
561007003981	Walker B; other site
561007003982	D-loop; other site
561007003983	H-loop/switch region; other site
561007003984	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
561007003985	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007003986	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
561007003987	AMP-binding enzyme; Region: AMP-binding; cl15778
561007003988	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007003989	Permease; Region: Permease; cl00510
561007003990	Permease; Region: Permease; cl00510
561007003991	mce related protein; Region: MCE; pfam02470
561007003992	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
561007003993	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007003994	mce related protein; Region: MCE; pfam02470
561007003995	mce related protein; Region: MCE; pfam02470
561007003996	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007003997	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007003998	mce related protein; Region: MCE; pfam02470
561007003999	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007004000	mce related protein; Region: MCE; pfam02470
561007004001	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007004002	mce related protein; Region: MCE; pfam02470
561007004003	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007004004	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007004005	glycyl-tRNA synthetase; Provisional; Region: PRK04173
561007004006	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
561007004007	motif 1; other site
561007004008	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
561007004009	active site
561007004010	motif 2; other site
561007004011	motif 3; other site
561007004012	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
561007004013	anticodon binding site; other site
561007004014	hypothetical protein; Provisional; Region: PRK06062
561007004015	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007004016	inhibitor-cofactor binding pocket; inhibition site
561007004017	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007004018	catalytic residue [active]
561007004019	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
561007004020	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
561007004021	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007004022	catalytic residue [active]
561007004023	Transcriptional regulators [Transcription]; Region: GntR; COG1802
561007004024	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007004025	DNA-binding site [nucleotide binding]; DNA binding site
561007004026	FCD domain; Region: FCD; cl11656
561007004027	Repair protein; Region: Repair_PSII; cl01535
561007004028	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
561007004029	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007004030	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
561007004031	DNA primase; Validated; Region: dnaG; PRK05667
561007004032	CHC2 zinc finger; Region: zf-CHC2; cl15369
561007004033	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
561007004034	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
561007004035	active site
561007004036	metal binding site [ion binding]; metal-binding site
561007004037	interdomain interaction site; other site
561007004038	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
561007004039	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
561007004040	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007004041	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
561007004042	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
561007004043	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
561007004044	Walker A/P-loop; other site
561007004045	ATP binding site [chemical binding]; other site
561007004046	Q-loop/lid; other site
561007004047	ABC transporter signature motif; other site
561007004048	Walker B; other site
561007004049	D-loop; other site
561007004050	H-loop/switch region; other site
561007004051	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
561007004052	Walker A/P-loop; other site
561007004053	ATP binding site [chemical binding]; other site
561007004054	Q-loop/lid; other site
561007004055	ABC transporter signature motif; other site
561007004056	Walker B; other site
561007004057	D-loop; other site
561007004058	H-loop/switch region; other site
561007004059	Cobalt transport protein; Region: CbiQ; cl00463
561007004060	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007004061	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
561007004062	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
561007004063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007004064	dimer interface [polypeptide binding]; other site
561007004065	conserved gate region; other site
561007004066	putative PBP binding loops; other site
561007004067	ABC-ATPase subunit interface; other site
561007004068	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
561007004069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007004070	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007004071	ABC-ATPase subunit interface; other site
561007004072	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
561007004073	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
561007004074	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
561007004075	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
561007004076	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007004077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007004078	active site
561007004079	phosphorylation site [posttranslational modification]
561007004080	intermolecular recognition site; other site
561007004081	dimerization interface [polypeptide binding]; other site
561007004082	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007004083	DNA binding site [nucleotide binding]
561007004084	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
561007004085	dimerization interface [polypeptide binding]; other site
561007004086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007004087	dimer interface [polypeptide binding]; other site
561007004088	phosphorylation site [posttranslational modification]
561007004089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007004090	ATP binding site [chemical binding]; other site
561007004091	Mg2+ binding site [ion binding]; other site
561007004092	G-X-G motif; other site
561007004093	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
561007004094	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
561007004095	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007004096	active site
561007004097	DNA binding site [nucleotide binding]
561007004098	Int/Topo IB signature motif; other site
561007004099	Protein of unknown function (DUF732); Region: DUF732; pfam05305
561007004100	Protein of unknown function (DUF732); Region: DUF732; pfam05305
561007004101	OpgC protein; Region: OpgC_C; cl00792
561007004102	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007004103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007004104	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
561007004105	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
561007004106	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007004107	Protein of unknown function (DUF732); Region: DUF732; pfam05305
561007004108	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
561007004109	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007004110	non-specific DNA binding site [nucleotide binding]; other site
561007004111	salt bridge; other site
561007004112	sequence-specific DNA binding site [nucleotide binding]; other site
561007004113	ERF superfamily; Region: ERF; pfam04404
561007004114	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
561007004115	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
561007004116	Ligand Binding Site [chemical binding]; other site
561007004117	Transcription factor WhiB; Region: Whib; pfam02467
561007004118	Domain of unknown function (DUF4326); Region: DUF4326; pfam14216
561007004119	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
561007004120	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007004121	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
561007004122	active site
561007004123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007004124	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
561007004125	Phage Terminase; Region: Terminase_1; pfam03354
561007004126	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
561007004127	P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl10302
561007004128	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
561007004129	Phage-related protein [Function unknown]; Region: COG5412
561007004130	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
561007004131	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
561007004132	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
561007004133	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007004134	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
561007004135	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
561007004136	active site
561007004137	Protein of unknown function (DUF2746); Region: DUF2746; pfam10874
561007004138	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
561007004139	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
561007004140	Int/Topo IB signature motif; other site
561007004141	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007004142	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
561007004143	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
561007004144	multiple promoter invertase; Provisional; Region: mpi; PRK13413
561007004145	catalytic residues [active]
561007004146	catalytic nucleophile [active]
561007004147	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
561007004148	Synaptic Flat tetramer interface [polypeptide binding]; other site
561007004149	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
561007004150	DNA-binding interface [nucleotide binding]; DNA binding site
561007004151	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007004152	NlpC/P60 family; Region: NLPC_P60; cl11438
561007004153	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007004154	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
561007004155	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
561007004156	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
561007004157	active site
561007004158	Zn binding site [ion binding]; other site
561007004159	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
561007004160	metal binding site [ion binding]; metal-binding site
561007004161	active site
561007004162	I-site; other site
561007004163	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
561007004164	active site
561007004165	catalytic residues [active]
561007004166	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
561007004167	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
561007004168	putative heme binding pocket [chemical binding]; other site
561007004169	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
561007004170	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007004171	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
561007004172	Walker A/P-loop; other site
561007004173	ATP binding site [chemical binding]; other site
561007004174	Q-loop/lid; other site
561007004175	ABC transporter signature motif; other site
561007004176	Walker B; other site
561007004177	D-loop; other site
561007004178	H-loop/switch region; other site
561007004179	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007004180	Walker A/P-loop; other site
561007004181	ATP binding site [chemical binding]; other site
561007004182	Q-loop/lid; other site
561007004183	ABC transporter signature motif; other site
561007004184	Walker B; other site
561007004185	D-loop; other site
561007004186	H-loop/switch region; other site
561007004187	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
561007004188	active site
561007004189	Zn binding site [ion binding]; other site
561007004190	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
561007004191	active site
561007004192	Zn binding site [ion binding]; other site
561007004193	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007004194	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007004195	active site
561007004196	Isochorismatase family; Region: Isochorismatase; pfam00857
561007004197	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
561007004198	catalytic triad [active]
561007004199	conserved cis-peptide bond; other site
561007004200	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
561007004201	homodimer interface [polypeptide binding]; other site
561007004202	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
561007004203	active site pocket [active]
561007004204	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007004205	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
561007004206	NAD(P) binding site [chemical binding]; other site
561007004207	manganese transport regulator MntR; Provisional; Region: PRK11050
561007004208	Helix-turn-helix domains; Region: HTH; cl00088
561007004209	Predicted transcriptional regulators [Transcription]; Region: COG1510
561007004210	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
561007004211	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007004212	Walker A/P-loop; other site
561007004213	ATP binding site [chemical binding]; other site
561007004214	Q-loop/lid; other site
561007004215	ABC transporter signature motif; other site
561007004216	Walker B; other site
561007004217	D-loop; other site
561007004218	H-loop/switch region; other site
561007004219	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004220	Helix-turn-helix domains; Region: HTH; cl00088
561007004221	formyl-CoA transferase; Region: oxalate_frc; TIGR03253
561007004222	CoA-transferase family III; Region: CoA_transf_3; pfam02515
561007004223	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007004224	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007004225	active site
561007004226	lipid-transfer protein; Provisional; Region: PRK08256
561007004227	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007004228	active site
561007004229	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
561007004230	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004231	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
561007004232	metal binding site [ion binding]; metal-binding site
561007004233	active site
561007004234	I-site; other site
561007004235	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
561007004236	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
561007004237	active site
561007004238	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
561007004239	mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
561007004240	NAD binding site [chemical binding]; other site
561007004241	catalytic Zn binding site [ion binding]; other site
561007004242	substrate binding site [chemical binding]; other site
561007004243	structural Zn binding site [ion binding]; other site
561007004244	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007004245	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
561007004246	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004247	Helix-turn-helix domains; Region: HTH; cl00088
561007004248	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007004249	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
561007004250	putative NAD(P) binding site [chemical binding]; other site
561007004251	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007004252	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007004253	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007004254	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
561007004255	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007004256	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
561007004257	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
561007004258	dimer interface [polypeptide binding]; other site
561007004259	active site
561007004260	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004261	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007004262	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
561007004263	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
561007004264	Helix-turn-helix domains; Region: HTH; cl00088
561007004265	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004266	Helix-turn-helix domains; Region: HTH; cl00088
561007004267	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
561007004268	Electron transfer DM13; Region: DM13; cl02735
561007004269	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
561007004270	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
561007004271	dimer interface [polypeptide binding]; other site
561007004272	TPP-binding site [chemical binding]; other site
561007004273	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
561007004274	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
561007004275	dimer interface [polypeptide binding]; other site
561007004276	catalytic triad [active]
561007004277	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
561007004278	active site
561007004279	CoA-transferase family III; Region: CoA_transf_3; pfam02515
561007004280	MspA; Region: MspA; pfam09203
561007004281	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
561007004282	High-affinity nickel-transport protein; Region: NicO; cl00964
561007004283	CobD/Cbib protein; Region: CobD_Cbib; cl00561
561007004284	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
561007004285	Low molecular weight phosphatase family; Region: LMWPc; cd00115
561007004286	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
561007004287	active site
561007004288	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
561007004289	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007004290	motif I; other site
561007004291	active site
561007004292	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007004293	motif II; other site
561007004294	hypothetical protein; Provisional; Region: PRK07908
561007004295	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007004296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007004297	homodimer interface [polypeptide binding]; other site
561007004298	catalytic residue [active]
561007004299	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
561007004300	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
561007004301	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
561007004302	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
561007004303	Putative zinc ribbon domain; Region: DUF164; pfam02591
561007004304	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
561007004305	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
561007004306	RNA/DNA hybrid binding site [nucleotide binding]; other site
561007004307	active site
561007004308	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007004309	catalytic core [active]
561007004310	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007004311	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
561007004312	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
561007004313	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
561007004314	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007004315	MoxR-like ATPases [General function prediction only]; Region: COG0714
561007004316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007004317	Walker A motif; other site
561007004318	ATP binding site [chemical binding]; other site
561007004319	Walker B motif; other site
561007004320	arginine finger; other site
561007004321	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
561007004322	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
561007004323	active site
561007004324	metal binding site [ion binding]; metal-binding site
561007004325	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
561007004326	RNB domain; Region: RNB; pfam00773
561007004327	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
561007004328	putative active site; other site
561007004329	putative metal binding residues [ion binding]; other site
561007004330	signature motif; other site
561007004331	putative triphosphate binding site [ion binding]; other site
561007004332	CHAD domain; Region: CHAD; cl10506
561007004333	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
561007004334	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004335	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
561007004336	oligomerization interface [polypeptide binding]; other site
561007004337	active site
561007004338	metal binding site [ion binding]; metal-binding site
561007004339	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
561007004340	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
561007004341	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
561007004342	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007004343	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
561007004344	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007004345	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
561007004346	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
561007004347	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
561007004348	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
561007004349	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
561007004350	metal binding triad; other site
561007004351	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
561007004352	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
561007004353	metal binding triad; other site
561007004354	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
561007004355	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007004356	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
561007004357	active site
561007004358	metal binding site [ion binding]; metal-binding site
561007004359	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007004360	Helix-turn-helix domains; Region: HTH; cl00088
561007004361	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007004362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007004363	active site
561007004364	phosphorylation site [posttranslational modification]
561007004365	intermolecular recognition site; other site
561007004366	dimerization interface [polypeptide binding]; other site
561007004367	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007004368	DNA binding site [nucleotide binding]
561007004369	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
561007004370	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007004371	phosphorylation site [posttranslational modification]
561007004372	dimer interface [polypeptide binding]; other site
561007004373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007004374	Mg2+ binding site [ion binding]; other site
561007004375	sensor protein PhoQ; Provisional; Region: PRK10815
561007004376	G-X-G motif; other site
561007004377	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007004378	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
561007004379	putative catalytic site [active]
561007004380	putative phosphate binding site [ion binding]; other site
561007004381	putative metal binding site [ion binding]; other site
561007004382	DoxX; Region: DoxX; cl00976
561007004383	DoxX; Region: DoxX; cl00976
561007004384	chaperone protein HchA; Provisional; Region: PRK04155
561007004385	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
561007004386	conserved cys residue [active]
561007004387	glutamine synthetase, type I; Region: GlnA; TIGR00653
561007004388	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
561007004389	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
561007004390	RDD family; Region: RDD; cl00746
561007004391	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
561007004392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007004393	putative substrate translocation pore; other site
561007004394	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007004395	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
561007004396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007004397	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004398	Helix-turn-helix domains; Region: HTH; cl00088
561007004399	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007004400	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
561007004401	lipoyl synthase; Provisional; Region: PRK05481
561007004402	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007004403	FeS/SAM binding site; other site
561007004404	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
561007004405	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
561007004406	TIGR01777 family protein; Region: yfcH
561007004407	putative NAD(P) binding site [chemical binding]; other site
561007004408	putative active site [active]
561007004409	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
561007004410	E3 interaction surface; other site
561007004411	lipoyl attachment site [posttranslational modification]; other site
561007004412	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
561007004413	E3 interaction surface; other site
561007004414	lipoyl attachment site [posttranslational modification]; other site
561007004415	e3 binding domain; Region: E3_binding; pfam02817
561007004416	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
561007004417	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
561007004418	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
561007004419	multifunctional aminopeptidase A; Provisional; Region: PRK00913
561007004420	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
561007004421	interface (dimer of trimers) [polypeptide binding]; other site
561007004422	Substrate-binding/catalytic site; other site
561007004423	Zn-binding sites [ion binding]; other site
561007004424	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
561007004425	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
561007004426	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
561007004427	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
561007004428	homodimer interface [polypeptide binding]; other site
561007004429	substrate-cofactor binding pocket; other site
561007004430	catalytic residue [active]
561007004431	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
561007004432	active site
561007004433	metal binding site [ion binding]; metal-binding site
561007004434	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
561007004435	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
561007004436	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
561007004437	putative dimer interface [polypeptide binding]; other site
561007004438	active site pocket [active]
561007004439	putative cataytic base [active]
561007004440	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
561007004441	homotrimer interface [polypeptide binding]; other site
561007004442	Walker A motif; other site
561007004443	GTP binding site [chemical binding]; other site
561007004444	Walker B motif; other site
561007004445	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
561007004446	Glycerate kinase family; Region: Gly_kinase; cl00841
561007004447	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
561007004448	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
561007004449	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
561007004450	substrate binding site [chemical binding]; other site
561007004451	ATP binding site [chemical binding]; other site
561007004452	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
561007004453	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
561007004454	active site
561007004455	dimer interface [polypeptide binding]; other site
561007004456	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
561007004457	Ligand Binding Site [chemical binding]; other site
561007004458	Molecular Tunnel; other site
561007004459	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
561007004460	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007004461	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
561007004462	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
561007004463	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007004464	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
561007004465	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
561007004466	heme bH binding site [chemical binding]; other site
561007004467	intrachain domain interface; other site
561007004468	heme bL binding site [chemical binding]; other site
561007004469	interchain domain interface [polypeptide binding]; other site
561007004470	Qo binding site; other site
561007004471	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
561007004472	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
561007004473	iron-sulfur cluster [ion binding]; other site
561007004474	[2Fe-2S] cluster binding site [ion binding]; other site
561007004475	Cytochrome c; Region: Cytochrom_C; cl11414
561007004476	Cytochrome c; Region: Cytochrom_C; cl11414
561007004477	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
561007004478	Subunit I/III interface [polypeptide binding]; other site
561007004479	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
561007004480	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
561007004481	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
561007004482	hypothetical protein; Validated; Region: PRK07883
561007004483	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
561007004484	active site
561007004485	catalytic site [active]
561007004486	substrate binding site [chemical binding]; other site
561007004487	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
561007004488	GIY-YIG motif/motif A; other site
561007004489	active site
561007004490	catalytic site [active]
561007004491	putative DNA binding site [nucleotide binding]; other site
561007004492	metal binding site [ion binding]; metal-binding site
561007004493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007004494	NlpC/P60 family; Region: NLPC_P60; cl11438
561007004495	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
561007004496	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
561007004497	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
561007004498	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007004499	S-adenosylmethionine binding site [chemical binding]; other site
561007004500	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
561007004501	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004502	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007004503	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007004504	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007004505	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
561007004506	putative hydrophobic ligand binding site [chemical binding]; other site
561007004507	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
561007004508	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
561007004509	P loop; other site
561007004510	Nucleotide binding site [chemical binding]; other site
561007004511	DTAP/Switch II; other site
561007004512	Switch I; other site
561007004513	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
561007004514	putative acyl-acceptor binding pocket; other site
561007004515	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
561007004516	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
561007004517	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
561007004518	Catalytic domain of Protein Kinases; Region: PKc; cd00180
561007004519	active site
561007004520	ATP binding site [chemical binding]; other site
561007004521	substrate binding site [chemical binding]; other site
561007004522	activation loop (A-loop); other site
561007004523	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
561007004524	putative hydrophobic ligand binding site [chemical binding]; other site
561007004525	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007004526	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
561007004527	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
561007004528	substrate binding pocket [chemical binding]; other site
561007004529	chain length determination region; other site
561007004530	substrate-Mg2+ binding site; other site
561007004531	catalytic residues [active]
561007004532	aspartate-rich region 1; other site
561007004533	active site lid residues [active]
561007004534	aspartate-rich region 2; other site
561007004535	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
561007004536	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
561007004537	FAD binding site [chemical binding]; other site
561007004538	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
561007004539	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007004540	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
561007004541	cell division protein MraZ; Reviewed; Region: PRK00326
561007004542	MraZ protein; Region: MraZ; pfam02381
561007004543	MraZ protein; Region: MraZ; pfam02381
561007004544	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
561007004545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007004546	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
561007004547	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
561007004548	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007004549	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
561007004550	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
561007004551	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
561007004552	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
561007004553	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
561007004554	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
561007004555	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
561007004556	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
561007004557	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
561007004558	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
561007004559	Mg++ binding site [ion binding]; other site
561007004560	putative catalytic motif [active]
561007004561	putative substrate binding site [chemical binding]; other site
561007004562	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
561007004563	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
561007004564	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
561007004565	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
561007004566	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
561007004567	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
561007004568	active site
561007004569	homodimer interface [polypeptide binding]; other site
561007004570	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
561007004571	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
561007004572	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
561007004573	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
561007004574	Cell division protein FtsQ; Region: FtsQ; pfam03799
561007004575	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
561007004576	nucleotide binding site [chemical binding]; other site
561007004577	SulA interaction site; other site
561007004578	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
561007004579	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
561007004580	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
561007004581	catalytic residue [active]
561007004582	Protein of unknown function (DUF552); Region: DUF552; cl00775
561007004583	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007004584	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007004585	dimerization interface [polypeptide binding]; other site
561007004586	putative DNA binding site [nucleotide binding]; other site
561007004587	putative Zn2+ binding site [ion binding]; other site
561007004588	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898
561007004589	putative hydrophobic ligand binding site [chemical binding]; other site
561007004590	DivIVA domain; Region: DivI1A_domain; TIGR03544
561007004591	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
561007004592	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
561007004593	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
561007004594	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007004595	Uncharacterized conserved protein [Function unknown]; Region: COG2128
561007004596	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007004597	Helix-turn-helix domains; Region: HTH; cl00088
561007004598	Transcriptional regulators [Transcription]; Region: PurR; COG1609
561007004599	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
561007004600	DNA binding site [nucleotide binding]
561007004601	domain linker motif; other site
561007004602	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
561007004603	ligand binding site [chemical binding]; other site
561007004604	dimerization interface [polypeptide binding]; other site
561007004605	amidase; Validated; Region: PRK06565
561007004606	Amidase; Region: Amidase; cl11426
561007004607	Amidase; Region: Amidase; cl11426
561007004608	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
561007004609	Na binding site [ion binding]; other site
561007004610	agmatine deiminase; Region: agmatine_aguA; TIGR03380
561007004611	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
561007004612	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004613	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
561007004614	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
561007004615	dimer interface [polypeptide binding]; other site
561007004616	active site
561007004617	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
561007004618	active site
561007004619	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
561007004620	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
561007004621	dimer interface [polypeptide binding]; other site
561007004622	active site
561007004623	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
561007004624	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
561007004625	active site
561007004626	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
561007004627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007004628	NAD(P) binding site [chemical binding]; other site
561007004629	active site
561007004630	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
561007004631	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007004632	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007004633	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
561007004634	acyltransferase PapA5; Provisional; Region: PRK09294
561007004635	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007004636	Transport protein; Region: actII; TIGR00833
561007004637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007004638	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007004639	putative substrate translocation pore; other site
561007004640	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007004641	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007004642	substrate binding pocket [chemical binding]; other site
561007004643	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007004644	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
561007004645	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188
561007004646	NAD(P) binding site [chemical binding]; other site
561007004647	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
561007004648	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007004649	active site
561007004650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004651	Helix-turn-helix domains; Region: HTH; cl00088
561007004652	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007004653	CoenzymeA binding site [chemical binding]; other site
561007004654	subunit interaction site [polypeptide binding]; other site
561007004655	PHB binding site; other site
561007004656	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007004657	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007004658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004659	Helix-turn-helix domains; Region: HTH; cl00088
561007004660	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
561007004661	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007004662	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007004663	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007004664	catalytic loop [active]
561007004665	iron binding site [ion binding]; other site
561007004666	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
561007004667	Helix-turn-helix domain; Region: HTH_18; pfam12833
561007004668	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007004669	thiolase; Provisional; Region: PRK06158
561007004670	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007004671	active site
561007004672	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
561007004673	DUF35 OB-fold domain; Region: DUF35; pfam01796
561007004674	methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271
561007004675	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007004676	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
561007004677	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007004678	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007004679	active site 2 [active]
561007004680	active site 1 [active]
561007004681	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007004682	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007004683	active site 2 [active]
561007004684	active site 1 [active]
561007004685	enoyl-CoA hydratase; Provisional; Region: PRK06494
561007004686	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007004687	substrate binding site [chemical binding]; other site
561007004688	oxyanion hole (OAH) forming residues; other site
561007004689	trimer interface [polypeptide binding]; other site
561007004690	TIGR03084 family protein; Region: TIGR03084
561007004691	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007004692	Wyosine base formation; Region: Wyosine_form; pfam08608
561007004693	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
561007004694	Helix-turn-helix domains; Region: HTH; cl00088
561007004695	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004696	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
561007004697	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007004698	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004699	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007004700	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007004701	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007004702	active site
561007004703	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
561007004704	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
561007004705	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007004706	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
561007004707	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
561007004708	carboxyltransferase (CT) interaction site; other site
561007004709	biotinylation site [posttranslational modification]; other site
561007004710	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
561007004711	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007004712	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007004713	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004714	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007004715	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007004716	Helix-turn-helix domains; Region: HTH; cl00088
561007004717	classical (c) SDRs; Region: SDR_c; cd05233
561007004718	short chain dehydrogenase; Provisional; Region: PRK05650
561007004719	NAD(P) binding site [chemical binding]; other site
561007004720	active site
561007004721	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007004722	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007004723	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007004724	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007004725	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007004726	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007004727	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007004728	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007004729	Cytochrome P450; Region: p450; pfam00067
561007004730	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
561007004731	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
561007004732	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
561007004733	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004734	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007004735	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007004736	active site
561007004737	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
561007004738	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
561007004739	putative active site [active]
561007004740	SCP-2 sterol transfer family; Region: SCP2; cl01225
561007004741	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
561007004742	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
561007004743	NAD binding site [chemical binding]; other site
561007004744	catalytic Zn binding site [ion binding]; other site
561007004745	substrate binding site [chemical binding]; other site
561007004746	structural Zn binding site [ion binding]; other site
561007004747	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007004748	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007004749	active site
561007004750	Integrase core domain; Region: rve; cl01316
561007004751	Integrase core domain; Region: rve_3; cl15866
561007004752	putative transposase OrfB; Reviewed; Region: PHA02517
561007004753	Integrase core domain; Region: rve; cl01316
561007004754	Integrase core domain; Region: rve_3; cl15866
561007004755	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
561007004756	active site
561007004757	nucleophile elbow; other site
561007004758	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
561007004759	active site
561007004760	NTP binding site [chemical binding]; other site
561007004761	metal binding triad [ion binding]; metal-binding site
561007004762	Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457
561007004763	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
561007004764	ATP binding site [chemical binding]; other site
561007004765	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007004766	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
561007004767	nudix motif; other site
561007004768	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007004769	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
561007004770	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
561007004771	catalytic residues [active]
561007004772	catalytic nucleophile [active]
561007004773	Recombinase; Region: Recombinase; pfam07508
561007004774	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
561007004775	hypothetical protein; Provisional; Region: PRK07906
561007004776	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
561007004777	putative metal binding site [ion binding]; other site
561007004778	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
561007004779	substrate binding site [chemical binding]; other site
561007004780	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
561007004781	quinone interaction residues [chemical binding]; other site
561007004782	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
561007004783	active site
561007004784	catalytic residues [active]
561007004785	FMN binding site [chemical binding]; other site
561007004786	substrate binding site [chemical binding]; other site
561007004787	PQQ-like domain; Region: PQQ_2; pfam13360
561007004788	Bacitracin resistance protein BacA; Region: BacA; cl00858
561007004789	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007004790	catalytic core [active]
561007004791	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
561007004792	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
561007004793	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
561007004794	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007004795	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
561007004796	active site
561007004797	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
561007004798	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
561007004799	active site
561007004800	HIGH motif; other site
561007004801	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
561007004802	active site
561007004803	KMSKS motif; other site
561007004804	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
561007004805	putative tRNA binding surface [nucleotide binding]; other site
561007004806	short chain dehydrogenase; Provisional; Region: PRK05872
561007004807	classical (c) SDRs; Region: SDR_c; cd05233
561007004808	NAD(P) binding site [chemical binding]; other site
561007004809	active site
561007004810	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007004811	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
561007004812	NADP binding site [chemical binding]; other site
561007004813	active site
561007004814	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004815	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007004816	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
561007004817	active site
561007004818	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
561007004819	peptide synthase; Provisional; Region: PRK12467
561007004820	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007004821	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004822	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004823	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004824	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007004825	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004826	peptide synthase; Provisional; Region: PRK12316
561007004827	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004828	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004829	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007004830	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004831	Condensation domain; Region: Condensation; pfam00668
561007004832	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
561007004833	Nonribosomal peptide synthase; Region: NRPS; pfam08415
561007004834	AMP-binding enzyme; Region: AMP-binding; cl15778
561007004835	acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188
561007004836	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007004837	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
561007004838	putative FMN binding site [chemical binding]; other site
561007004839	NADPH bind site [chemical binding]; other site
561007004840	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
561007004841	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
561007004842	phosphate binding site [ion binding]; other site
561007004843	UPF0126 domain; Region: UPF0126; pfam03458
561007004844	UPF0126 domain; Region: UPF0126; pfam03458
561007004845	PAC2 family; Region: PAC2; cl00847
561007004846	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
561007004847	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
561007004848	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
561007004849	substrate binding pocket [chemical binding]; other site
561007004850	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
561007004851	B12 binding site [chemical binding]; other site
561007004852	cobalt ligand [ion binding]; other site
561007004853	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
561007004854	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
561007004855	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007004856	motif II; other site
561007004857	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007004858	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
561007004859	homodimer interface [polypeptide binding]; other site
561007004860	putative metal binding site [ion binding]; other site
561007004861	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
561007004862	ATP phosphoribosyltransferase; Region: HisG; cl15266
561007004863	HisG, C-terminal domain; Region: HisG_C; cl06867
561007004864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
561007004865	active site
561007004866	phosphorylation site [posttranslational modification]
561007004867	intermolecular recognition site; other site
561007004868	dimerization interface [polypeptide binding]; other site
561007004869	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
561007004870	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
561007004871	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
561007004872	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
561007004873	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
561007004874	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
561007004875	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
561007004876	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
561007004877	putative dimer interface [polypeptide binding]; other site
561007004878	[2Fe-2S] cluster binding site [ion binding]; other site
561007004879	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
561007004880	SLBB domain; Region: SLBB; pfam10531
561007004881	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
561007004882	NADH dehydrogenase subunit G; Validated; Region: PRK07860
561007004883	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007004884	catalytic loop [active]
561007004885	iron binding site [ion binding]; other site
561007004886	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
561007004887	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
561007004888	molybdopterin cofactor binding site; other site
561007004889	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
561007004890	NADH dehydrogenase; Region: NADHdh; cl00469
561007004891	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
561007004892	4Fe-4S binding domain; Region: Fer4; cl02805
561007004893	4Fe-4S binding domain; Region: Fer4; cl02805
561007004894	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
561007004895	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
561007004896	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
561007004897	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
561007004898	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
561007004899	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
561007004900	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
561007004901	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
561007004902	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
561007004903	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
561007004904	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
561007004905	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
561007004906	putative di-iron ligands [ion binding]; other site
561007004907	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007004908	Cytochrome P450; Region: p450; pfam00067
561007004909	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007004910	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007004911	Helix-turn-helix domains; Region: HTH; cl00088
561007004912	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
561007004913	MOSC domain; Region: MOSC; pfam03473
561007004914	3-alpha domain; Region: 3-alpha; pfam03475
561007004915	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
561007004916	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007004917	active site 2 [active]
561007004918	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
561007004919	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
561007004920	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
561007004921	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007004922	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
561007004923	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
561007004924	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
561007004925	homodimer interface [polypeptide binding]; other site
561007004926	putative substrate binding pocket [chemical binding]; other site
561007004927	diiron center [ion binding]; other site
561007004928	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
561007004929	DEAD-like helicases superfamily; Region: DEXDc; smart00487
561007004930	ATP binding site [chemical binding]; other site
561007004931	Mg++ binding site [ion binding]; other site
561007004932	motif III; other site
561007004933	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007004934	nucleotide binding region [chemical binding]; other site
561007004935	ATP-binding site [chemical binding]; other site
561007004936	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
561007004937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007004938	S-adenosylmethionine binding site [chemical binding]; other site
561007004939	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
561007004940	proteasome ATPase; Region: pup_AAA; TIGR03689
561007004941	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007004942	Walker A motif; other site
561007004943	ATP binding site [chemical binding]; other site
561007004944	Walker B motif; other site
561007004945	arginine finger; other site
561007004946	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
561007004947	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007004948	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007004949	DNA binding residues [nucleotide binding]
561007004950	Putative zinc-finger; Region: zf-HC2; cl15806
561007004951	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
561007004952	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
561007004953	PYR/PP interface [polypeptide binding]; other site
561007004954	dimer interface [polypeptide binding]; other site
561007004955	TPP binding site [chemical binding]; other site
561007004956	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
561007004957	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
561007004958	TPP-binding site [chemical binding]; other site
561007004959	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
561007004960	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
561007004961	active site
561007004962	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
561007004963	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007004964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007004965	homodimer interface [polypeptide binding]; other site
561007004966	catalytic residue [active]
561007004967	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007004968	Pup-ligase protein; Region: Pup_ligase; cl15463
561007004969	Pup-like protein; Region: Pup; cl05289
561007004970	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
561007004971	active site
561007004972	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
561007004973	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
561007004974	active site
561007004975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007004976	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
561007004977	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
561007004978	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
561007004979	substrate binding pocket [chemical binding]; other site
561007004980	membrane-bound complex binding site; other site
561007004981	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
561007004982	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
561007004983	Walker A/P-loop; other site
561007004984	ATP binding site [chemical binding]; other site
561007004985	Q-loop/lid; other site
561007004986	ABC transporter signature motif; other site
561007004987	Walker B; other site
561007004988	D-loop; other site
561007004989	H-loop/switch region; other site
561007004990	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007004991	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
561007004992	Amidase; Region: Amidase; cl11426
561007004993	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
561007004994	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
561007004995	Pup-ligase protein; Region: Pup_ligase; cl15463
561007004996	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
561007004997	Predicted transcriptional regulator [Transcription]; Region: COG2378
561007004998	WYL domain; Region: WYL; cl14852
561007004999	Predicted transcriptional regulator [Transcription]; Region: COG2378
561007005000	WYL domain; Region: WYL; cl14852
561007005001	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
561007005002	twin arginine translocase protein A; Provisional; Region: tatA; PRK00191
561007005003	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
561007005004	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
561007005005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007005006	ATP binding site [chemical binding]; other site
561007005007	putative Mg++ binding site [ion binding]; other site
561007005008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007005009	nucleotide binding region [chemical binding]; other site
561007005010	ATP-binding site [chemical binding]; other site
561007005011	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
561007005012	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
561007005013	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
561007005014	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
561007005015	active site
561007005016	metal binding site 1 [ion binding]; metal-binding site
561007005017	putative 5' ssDNA interaction site; other site
561007005018	metal binding site 3; metal-binding site
561007005019	metal binding site 2 [ion binding]; metal-binding site
561007005020	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
561007005021	putative DNA binding site [nucleotide binding]; other site
561007005022	putative metal binding site [ion binding]; other site
561007005023	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
561007005024	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
561007005025	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
561007005026	active site
561007005027	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007005028	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
561007005029	classical (c) SDRs; Region: SDR_c; cd05233
561007005030	NAD(P) binding site [chemical binding]; other site
561007005031	active site
561007005032	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
561007005033	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007005034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007005035	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007005036	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
561007005037	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
561007005038	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
561007005039	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007005040	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
561007005041	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007005042	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
561007005043	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
561007005044	precorrin-3B synthase; Region: CobG; TIGR02435
561007005045	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
561007005046	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
561007005047	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
561007005048	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007005049	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007005050	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
561007005051	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
561007005052	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
561007005053	active site
561007005054	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
561007005055	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
561007005056	putative active site [active]
561007005057	catalytic triad [active]
561007005058	putative dimer interface [polypeptide binding]; other site
561007005059	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
561007005060	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
561007005061	Ligand binding site; other site
561007005062	Putative Catalytic site; other site
561007005063	DXD motif; other site
561007005064	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
561007005065	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007005066	Transport protein; Region: actII; TIGR00833
561007005067	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007005068	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
561007005069	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007005070	active site
561007005071	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007005072	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
561007005073	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005074	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
561007005075	Enoylreductase; Region: PKS_ER; smart00829
561007005076	NAD(P) binding site [chemical binding]; other site
561007005077	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
561007005078	putative NADP binding site [chemical binding]; other site
561007005079	active site
561007005080	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007005081	Thioesterase domain; Region: Thioesterase; pfam00975
561007005082	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
561007005083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007005084	dimer interface [polypeptide binding]; other site
561007005085	conserved gate region; other site
561007005086	putative PBP binding loops; other site
561007005087	ABC-ATPase subunit interface; other site
561007005088	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
561007005089	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
561007005090	Walker A/P-loop; other site
561007005091	ATP binding site [chemical binding]; other site
561007005092	Q-loop/lid; other site
561007005093	ABC transporter signature motif; other site
561007005094	Walker B; other site
561007005095	D-loop; other site
561007005096	H-loop/switch region; other site
561007005097	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
561007005098	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
561007005099	substrate binding pocket [chemical binding]; other site
561007005100	membrane-bound complex binding site; other site
561007005101	hinge residues; other site
561007005102	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
561007005103	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
561007005104	active site
561007005105	dimer interface [polypeptide binding]; other site
561007005106	non-prolyl cis peptide bond; other site
561007005107	insertion regions; other site
561007005108	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007005109	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
561007005110	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
561007005111	TspO/MBR family; Region: TspO_MBR; cl01379
561007005112	Protein of unknown function (DUF2984); Region: DUF2984; cl12752
561007005113	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
561007005114	active site
561007005115	catalytic residues [active]
561007005116	Ubiquitin-like proteins; Region: UBQ; cl00155
561007005117	EspG family; Region: ESX-1_EspG; pfam14011
561007005118	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007005119	PPE family; Region: PPE; pfam00823
561007005120	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
561007005121	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005122	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
561007005123	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005124	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005125	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005126	Protein of unknown function (DUF690); Region: DUF690; cl04939
561007005127	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
561007005128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007005129	Walker A motif; other site
561007005130	ATP binding site [chemical binding]; other site
561007005131	Walker B motif; other site
561007005132	arginine finger; other site
561007005133	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
561007005134	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
561007005135	FAD binding pocket [chemical binding]; other site
561007005136	FAD binding motif [chemical binding]; other site
561007005137	phosphate binding motif [ion binding]; other site
561007005138	NAD binding pocket [chemical binding]; other site
561007005139	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005140	NAD(P) binding site [chemical binding]; other site
561007005141	hypothetical protein; Provisional; Region: PRK07538
561007005142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005143	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
561007005144	Helix-turn-helix domains; Region: HTH; cl00088
561007005145	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
561007005146	putative dimerization interface [polypeptide binding]; other site
561007005147	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007005148	DNA-binding site [nucleotide binding]; DNA binding site
561007005149	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
561007005150	UTRA domain; Region: UTRA; cl01230
561007005151	archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700
561007005152	NMT1-like family; Region: NMT1_2; cl15260
561007005153	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
561007005154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007005155	dimer interface [polypeptide binding]; other site
561007005156	conserved gate region; other site
561007005157	putative PBP binding loops; other site
561007005158	ABC-ATPase subunit interface; other site
561007005159	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
561007005160	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
561007005161	Walker A/P-loop; other site
561007005162	ATP binding site [chemical binding]; other site
561007005163	Q-loop/lid; other site
561007005164	ABC transporter signature motif; other site
561007005165	Walker B; other site
561007005166	D-loop; other site
561007005167	H-loop/switch region; other site
561007005168	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
561007005169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005170	salicylate synthase MbtI; Reviewed; Region: PRK07912
561007005171	chorismate binding enzyme; Region: Chorismate_bind; cl10555
561007005172	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007005173	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
561007005174	DNA binding residues [nucleotide binding]
561007005175	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
561007005176	catalytic triad [active]
561007005177	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
561007005178	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005179	peptide synthase; Provisional; Region: PRK12467
561007005180	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005181	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007005182	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007005183	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
561007005184	MbtH-like protein; Region: MbtH; cl01279
561007005185	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
561007005186	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007005187	PPE family; Region: PPE; pfam00823
561007005188	Condensation domain; Region: Condensation; pfam00668
561007005189	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
561007005190	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007005191	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005192	acyl-CoA synthetase; Validated; Region: PRK08308
561007005193	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007005194	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
561007005195	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007005196	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007005197	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
561007005198	active site
561007005199	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
561007005200	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007005201	peptide synthase; Provisional; Region: PRK12316
561007005202	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007005203	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007005204	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
561007005205	active site
561007005206	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007005207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007005208	peptide synthase; Validated; Region: PRK05691
561007005209	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007005210	peptide synthase; Provisional; Region: PRK12467
561007005211	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007005212	peptide synthase; Provisional; Region: PRK12316
561007005213	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
561007005214	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005215	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
561007005216	putative NADP binding site [chemical binding]; other site
561007005217	active site
561007005218	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
561007005219	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007005220	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007005221	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
561007005222	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
561007005223	active site
561007005224	substrate binding site [chemical binding]; other site
561007005225	cosubstrate binding site; other site
561007005226	catalytic site [active]
561007005227	Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785
561007005228	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
561007005229	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005230	Walker A/P-loop; other site
561007005231	ATP binding site [chemical binding]; other site
561007005232	Q-loop/lid; other site
561007005233	ABC transporter signature motif; other site
561007005234	Walker B; other site
561007005235	D-loop; other site
561007005236	H-loop/switch region; other site
561007005237	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
561007005238	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
561007005239	FAD binding pocket [chemical binding]; other site
561007005240	FAD binding motif [chemical binding]; other site
561007005241	phosphate binding motif [ion binding]; other site
561007005242	NAD binding pocket [chemical binding]; other site
561007005243	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
561007005244	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
561007005245	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005246	Walker A/P-loop; other site
561007005247	ATP binding site [chemical binding]; other site
561007005248	Q-loop/lid; other site
561007005249	ABC transporter signature motif; other site
561007005250	Walker B; other site
561007005251	D-loop; other site
561007005252	H-loop/switch region; other site
561007005253	metabolite-proton symporter; Region: 2A0106; TIGR00883
561007005254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007005255	putative substrate translocation pore; other site
561007005256	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
561007005257	Cupin domain; Region: Cupin_2; cl09118
561007005258	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
561007005259	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007005260	inhibitor-cofactor binding pocket; inhibition site
561007005261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007005262	catalytic residue [active]
561007005263	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007005264	Coenzyme A binding pocket [chemical binding]; other site
561007005265	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
561007005266	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
561007005267	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
561007005268	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007005269	DNA binding residues [nucleotide binding]
561007005270	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
561007005271	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
561007005272	Protein of unknown function (DUF461); Region: DUF461; cl01071
561007005273	Transcriptional regulators [Transcription]; Region: FadR; COG2186
561007005274	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007005275	DNA-binding site [nucleotide binding]; DNA binding site
561007005276	FCD domain; Region: FCD; cl11656
561007005277	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
561007005278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007005279	putative substrate translocation pore; other site
561007005280	DoxX; Region: DoxX; cl00976
561007005281	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
561007005282	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
561007005283	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007005284	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
561007005285	NAD(P) binding site [chemical binding]; other site
561007005286	catalytic residues [active]
561007005287	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007005288	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007005289	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
561007005290	inhibitor-cofactor binding pocket; inhibition site
561007005291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007005292	catalytic residue [active]
561007005293	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
561007005294	putative hydrophobic ligand binding site [chemical binding]; other site
561007005295	Flavin Reductases; Region: FlaRed; cl00801
561007005296	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005297	FAD dependent oxidoreductase; Region: DAO; pfam01266
561007005298	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005299	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
561007005300	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
561007005301	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
561007005302	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007005303	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007005304	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007005305	Helix-turn-helix domains; Region: HTH; cl00088
561007005306	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
561007005307	putative hydrophobic ligand binding site [chemical binding]; other site
561007005308	protein interface [polypeptide binding]; other site
561007005309	gate; other site
561007005310	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
561007005311	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005312	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007005313	Helix-turn-helix domains; Region: HTH; cl00088
561007005314	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007005315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005316	Protease prsW family; Region: PrsW-protease; cl15823
561007005317	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
561007005318	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
561007005319	RNA binding site [nucleotide binding]; other site
561007005320	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
561007005321	RNA binding site [nucleotide binding]; other site
561007005322	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
561007005323	RNA binding site [nucleotide binding]; other site
561007005324	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
561007005325	RNA binding site [nucleotide binding]; other site
561007005326	Predicted RNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG2263
561007005327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007005328	S-adenosylmethionine binding site [chemical binding]; other site
561007005329	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
561007005330	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
561007005331	CoA-binding site [chemical binding]; other site
561007005332	ATP-binding [chemical binding]; other site
561007005333	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
561007005334	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007005335	Helix-turn-helix domains; Region: HTH; cl00088
561007005336	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007005337	Transport protein; Region: actII; TIGR00833
561007005338	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007005339	Transport protein; Region: actII; TIGR00833
561007005340	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
561007005341	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
561007005342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005343	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
561007005344	Protein of unknown function (DUF402); Region: DUF402; cl00979
561007005345	excinuclease ABC subunit B; Provisional; Region: PRK05298
561007005346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007005347	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007005348	nucleotide binding region [chemical binding]; other site
561007005349	ATP-binding site [chemical binding]; other site
561007005350	Ultra-violet resistance protein B; Region: UvrB; pfam12344
561007005351	UvrB/uvrC motif; Region: UVR; pfam02151
561007005352	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
561007005353	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007005354	DNA binding residues [nucleotide binding]
561007005355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007005356	putative substrate translocation pore; other site
561007005357	hypothetical protein; Provisional; Region: PRK09133
561007005358	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
561007005359	putative metal binding site [ion binding]; other site
561007005360	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007005361	Ligand Binding Site [chemical binding]; other site
561007005362	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007005363	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
561007005364	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
561007005365	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
561007005366	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
561007005367	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
561007005368	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005369	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007005370	Predicted esterase [General function prediction only]; Region: COG0627
561007005371	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007005372	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
561007005373	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
561007005374	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
561007005375	dimer interface [polypeptide binding]; other site
561007005376	putative anticodon binding site; other site
561007005377	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
561007005378	motif 1; other site
561007005379	dimer interface [polypeptide binding]; other site
561007005380	active site
561007005381	motif 2; other site
561007005382	motif 3; other site
561007005383	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
561007005384	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
561007005385	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
561007005386	ribosomal protein L20; Region: rpl20; CHL00068
561007005387	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
561007005388	23S rRNA binding site [nucleotide binding]; other site
561007005389	L21 binding site [polypeptide binding]; other site
561007005390	L13 binding site [polypeptide binding]; other site
561007005391	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
561007005392	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
561007005393	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
561007005394	short chain dehydrogenase; Provisional; Region: PRK06197
561007005395	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005396	NAD(P) binding site [chemical binding]; other site
561007005397	active site
561007005398	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007005399	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007005400	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
561007005401	MspA; Region: MspA; pfam09203
561007005402	cyclase homology domain; Region: CHD; cd07302
561007005403	nucleotidyl binding site; other site
561007005404	metal binding site [ion binding]; metal-binding site
561007005405	dimer interface [polypeptide binding]; other site
561007005406	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
561007005407	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
561007005408	active site
561007005409	DNA binding site [nucleotide binding]
561007005410	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
561007005411	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
561007005412	AlkA N-terminal domain; Region: AlkA_N; cl05528
561007005413	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
561007005414	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
561007005415	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
561007005416	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
561007005417	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
561007005418	dimer interface [polypeptide binding]; other site
561007005419	motif 1; other site
561007005420	active site
561007005421	motif 2; other site
561007005422	motif 3; other site
561007005423	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
561007005424	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
561007005425	putative tRNA-binding site [nucleotide binding]; other site
561007005426	B3/4 domain; Region: B3_4; cl11458
561007005427	tRNA synthetase B5 domain; Region: B5; cl08394
561007005428	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
561007005429	dimer interface [polypeptide binding]; other site
561007005430	motif 1; other site
561007005431	motif 3; other site
561007005432	motif 2; other site
561007005433	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
561007005434	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
561007005435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005436	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
561007005437	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
561007005438	heterotetramer interface [polypeptide binding]; other site
561007005439	active site pocket [active]
561007005440	cleavage site
561007005441	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
561007005442	feedback inhibition sensing region; other site
561007005443	homohexameric interface [polypeptide binding]; other site
561007005444	nucleotide binding site [chemical binding]; other site
561007005445	N-acetyl-L-glutamate binding site [chemical binding]; other site
561007005446	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
561007005447	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007005448	inhibitor-cofactor binding pocket; inhibition site
561007005449	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007005450	catalytic residue [active]
561007005451	ornithine carbamoyltransferase; Provisional; Region: PRK00779
561007005452	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
561007005453	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005454	arginine repressor; Provisional; Region: PRK03341
561007005455	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
561007005456	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
561007005457	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
561007005458	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
561007005459	ANP binding site [chemical binding]; other site
561007005460	Substrate Binding Site II [chemical binding]; other site
561007005461	Substrate Binding Site I [chemical binding]; other site
561007005462	argininosuccinate lyase; Provisional; Region: PRK00855
561007005463	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
561007005464	active sites [active]
561007005465	tetramer interface [polypeptide binding]; other site
561007005466	aspartate kinase, monofunctional class; Region: asp_kin_monofn; TIGR00656
561007005467	Competence-damaged protein; Region: CinA; cl00666
561007005468	acyl-CoA synthetase; Validated; Region: PRK07868
561007005469	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007005471	Helix-turn-helix domains; Region: HTH; cl00088
561007005472	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
561007005473	active site
561007005474	DNA binding site [nucleotide binding]
561007005475	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
561007005476	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
561007005477	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
561007005478	active site
561007005479	HIGH motif; other site
561007005480	dimer interface [polypeptide binding]; other site
561007005481	KMSKS motif; other site
561007005482	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
561007005483	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
561007005484	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005485	Walker A/P-loop; other site
561007005486	ATP binding site [chemical binding]; other site
561007005487	Q-loop/lid; other site
561007005488	ABC transporter signature motif; other site
561007005489	Walker B; other site
561007005490	D-loop; other site
561007005491	H-loop/switch region; other site
561007005492	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
561007005493	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
561007005494	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007005495	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007005496	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
561007005497	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
561007005498	RNA binding surface [nucleotide binding]; other site
561007005499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007005500	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
561007005501	DNA repair protein RecN; Region: recN; TIGR00634
561007005502	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
561007005503	Walker A/P-loop; other site
561007005504	ATP binding site [chemical binding]; other site
561007005505	Q-loop/lid; other site
561007005506	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
561007005507	ABC transporter signature motif; other site
561007005508	Walker B; other site
561007005509	D-loop; other site
561007005510	H-loop/switch region; other site
561007005511	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
561007005512	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
561007005513	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
561007005514	CTP synthetase; Validated; Region: pyrG; PRK05380
561007005515	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
561007005516	Catalytic site [active]
561007005517	active site
561007005518	UTP binding site [chemical binding]; other site
561007005519	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
561007005520	active site
561007005521	putative oxyanion hole; other site
561007005522	catalytic triad [active]
561007005523	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
561007005524	dimer interface [polypeptide binding]; other site
561007005525	active site
561007005526	ADP-ribose binding site [chemical binding]; other site
561007005527	nudix motif; other site
561007005528	metal binding site [ion binding]; metal-binding site
561007005529	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
561007005530	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
561007005531	active site
561007005532	Int/Topo IB signature motif; other site
561007005533	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
561007005534	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007005535	P-loop; other site
561007005536	Magnesium ion binding site [ion binding]; other site
561007005537	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007005538	Magnesium ion binding site [ion binding]; other site
561007005539	ScpA/B protein; Region: ScpA_ScpB; cl00598
561007005540	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
561007005541	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
561007005542	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
561007005543	RNA binding surface [nucleotide binding]; other site
561007005544	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
561007005545	active site
561007005546	cytidylate kinase; Provisional; Region: cmk; PRK00023
561007005547	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
561007005548	CMP-binding site; other site
561007005549	The sites determining sugar specificity; other site
561007005550	GTP-binding protein Der; Reviewed; Region: PRK03003
561007005551	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
561007005552	G1 box; other site
561007005553	GTP/Mg2+ binding site [chemical binding]; other site
561007005554	Switch I region; other site
561007005555	G2 box; other site
561007005556	Switch II region; other site
561007005557	G3 box; other site
561007005558	G4 box; other site
561007005559	G5 box; other site
561007005560	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
561007005561	G1 box; other site
561007005562	GTP/Mg2+ binding site [chemical binding]; other site
561007005563	Switch I region; other site
561007005564	G2 box; other site
561007005565	G3 box; other site
561007005566	Switch II region; other site
561007005567	G4 box; other site
561007005568	G5 box; other site
561007005569	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
561007005570	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
561007005571	dimerization interface [polypeptide binding]; other site
561007005572	mannose binding site [chemical binding]; other site
561007005573	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
561007005574	Domain of unknown function (DUF222); Region: DUF222; pfam02720
561007005575	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
561007005576	active site
561007005577	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
561007005578	Helix-turn-helix domains; Region: HTH; cl00088
561007005579	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
561007005580	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
561007005581	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
561007005582	FMN-binding pocket [chemical binding]; other site
561007005583	flavin binding motif; other site
561007005584	phosphate binding motif [ion binding]; other site
561007005585	beta-alpha-beta structure motif; other site
561007005586	NAD binding pocket [chemical binding]; other site
561007005587	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007005588	catalytic loop [active]
561007005589	iron binding site [ion binding]; other site
561007005590	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007005591	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
561007005592	A new structural DNA glycosylase; Region: AlkD_like; cd06561
561007005593	active site
561007005594	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: APH; cd05150
561007005595	Phosphotransferase enzyme family; Region: APH; pfam01636
561007005596	active site
561007005597	ATP binding site [chemical binding]; other site
561007005598	antibiotic binding site [chemical binding]; other site
561007005599	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007005600	dimerization interface [polypeptide binding]; other site
561007005601	putative DNA binding site [nucleotide binding]; other site
561007005602	putative Zn2+ binding site [ion binding]; other site
561007005603	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
561007005604	putative hydrophobic ligand binding site [chemical binding]; other site
561007005605	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
561007005606	dimer interface [polypeptide binding]; other site
561007005607	substrate binding site [chemical binding]; other site
561007005608	metal binding site [ion binding]; metal-binding site
561007005609	hypothetical protein; Validated; Region: PRK07121
561007005610	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007005611	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007005612	Helix-turn-helix domains; Region: HTH; cl00088
561007005613	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007005614	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
561007005615	active site
561007005616	ATP binding site [chemical binding]; other site
561007005617	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
561007005618	hydrophobic ligand binding site; other site
561007005619	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007005620	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007005621	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007005622	active site
561007005623	Predicted acetyltransferase [General function prediction only]; Region: COG3393
561007005624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007005625	Coenzyme A binding pocket [chemical binding]; other site
561007005626	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
561007005627	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
561007005628	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007005629	nucleotide binding region [chemical binding]; other site
561007005630	ATP-binding site [chemical binding]; other site
561007005631	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
561007005632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
561007005633	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
561007005634	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
561007005635	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
561007005636	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
561007005637	lipoyl attachment site [posttranslational modification]; other site
561007005638	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
561007005639	phosphopeptide binding site; other site
561007005640	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
561007005641	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
561007005642	DNA binding residues [nucleotide binding]
561007005643	Bifunctional nuclease; Region: DNase-RNase; cl00553
561007005644	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
561007005645	DNA binding residues [nucleotide binding]
561007005646	putative dimer interface [polypeptide binding]; other site
561007005647	glycine dehydrogenase; Provisional; Region: PRK05367
561007005648	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
561007005649	tetramer interface [polypeptide binding]; other site
561007005650	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007005651	catalytic residue [active]
561007005652	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
561007005653	tetramer interface [polypeptide binding]; other site
561007005654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007005655	catalytic residue [active]
561007005656	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
561007005657	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007005658	metal ion-dependent adhesion site (MIDAS); other site
561007005659	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
561007005660	active site
561007005661	Domain of unknown function DUF21; Region: DUF21; pfam01595
561007005662	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
561007005663	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
561007005664	Domain of unknown function DUF21; Region: DUF21; pfam01595
561007005665	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
561007005666	Transporter associated domain; Region: CorC_HlyC; cl08393
561007005667	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
561007005668	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
561007005669	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
561007005670	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
561007005671	active site
561007005672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005673	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
561007005674	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
561007005675	Peptidase family M48; Region: Peptidase_M48; cl12018
561007005676	Helix-turn-helix domains; Region: HTH; cl00088
561007005677	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007005678	CoenzymeA binding site [chemical binding]; other site
561007005679	subunit interaction site [polypeptide binding]; other site
561007005680	PHB binding site; other site
561007005681	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007005682	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007005683	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007005684	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007005685	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
561007005686	alpha-gamma subunit interface [polypeptide binding]; other site
561007005687	beta-gamma subunit interface [polypeptide binding]; other site
561007005688	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
561007005689	gamma-beta subunit interface [polypeptide binding]; other site
561007005690	alpha-beta subunit interface [polypeptide binding]; other site
561007005691	urease subunit alpha; Reviewed; Region: ureC; PRK13206
561007005692	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
561007005693	subunit interactions [polypeptide binding]; other site
561007005694	active site
561007005695	flap region; other site
561007005696	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
561007005697	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005698	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
561007005699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005700	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007005701	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
561007005702	TIGR03086 family protein; Region: TIGR03086
561007005703	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007005704	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
561007005705	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005706	short chain dehydrogenase; Provisional; Region: PRK12939
561007005707	NAD(P) binding site [chemical binding]; other site
561007005708	active site
561007005709	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
561007005710	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007005711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007005712	dimer interface [polypeptide binding]; other site
561007005713	conserved gate region; other site
561007005714	putative PBP binding loops; other site
561007005715	ABC-ATPase subunit interface; other site
561007005716	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
561007005717	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007005718	Walker A/P-loop; other site
561007005719	ATP binding site [chemical binding]; other site
561007005720	Q-loop/lid; other site
561007005721	ABC transporter signature motif; other site
561007005722	Walker B; other site
561007005723	D-loop; other site
561007005724	H-loop/switch region; other site
561007005725	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
561007005726	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
561007005727	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
561007005728	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
561007005729	molybdopterin cofactor binding site; other site
561007005730	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
561007005731	molybdopterin cofactor binding site; other site
561007005732	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
561007005733	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007005734	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
561007005735	FAD binding pocket [chemical binding]; other site
561007005736	FAD binding motif [chemical binding]; other site
561007005737	catalytic residues [active]
561007005738	NAD binding pocket [chemical binding]; other site
561007005739	phosphate binding motif [ion binding]; other site
561007005740	beta-alpha-beta structure motif; other site
561007005741	CrcB-like protein; Region: CRCB; cl09114
561007005742	CrcB-like protein; Region: CRCB; cl09114
561007005743	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007005744	Ligand Binding Site [chemical binding]; other site
561007005745	competence damage-inducible protein A; Provisional; Region: PRK00549
561007005746	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
561007005747	putative MPT binding site; other site
561007005748	Competence-damaged protein; Region: CinA; cl00666
561007005749	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007005750	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
561007005751	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
561007005752	conserved cys residue [active]
561007005753	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007005754	Pirin-related protein [General function prediction only]; Region: COG1741
561007005755	Cupin domain; Region: Cupin_2; cl09118
561007005756	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
561007005757	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007005758	Helix-turn-helix domains; Region: HTH; cl00088
561007005759	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
561007005760	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007005761	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
561007005762	Bacitracin resistance protein BacA; Region: BacA; cl00858
561007005763	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
561007005764	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007005765	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
561007005766	active site
561007005767	catalytic triad [active]
561007005768	oxyanion hole [active]
561007005769	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007005770	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
561007005771	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
561007005772	FAD binding domain; Region: FAD_binding_4; pfam01565
561007005773	Berberine and berberine like; Region: BBE; pfam08031
561007005774	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
561007005775	putative hydrophobic ligand binding site [chemical binding]; other site
561007005776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007005777	Helix-turn-helix domains; Region: HTH; cl00088
561007005778	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
561007005779	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007005780	active site
561007005781	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
561007005782	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
561007005783	Walker A/P-loop; other site
561007005784	ATP binding site [chemical binding]; other site
561007005785	Q-loop/lid; other site
561007005786	ABC transporter signature motif; other site
561007005787	Walker B; other site
561007005788	D-loop; other site
561007005789	H-loop/switch region; other site
561007005790	NMT1-like family; Region: NMT1_2; cl15260
561007005791	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
561007005792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007005793	dimer interface [polypeptide binding]; other site
561007005794	conserved gate region; other site
561007005795	putative PBP binding loops; other site
561007005796	ABC-ATPase subunit interface; other site
561007005797	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007005798	substrate binding site [chemical binding]; other site
561007005799	oxyanion hole (OAH) forming residues; other site
561007005800	trimer interface [polypeptide binding]; other site
561007005801	Helix-turn-helix domains; Region: HTH; cl00088
561007005802	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
561007005803	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
561007005804	heme bH binding site [chemical binding]; other site
561007005805	Qi binding site; other site
561007005806	intrachain domain interface; other site
561007005807	heme bL binding site [chemical binding]; other site
561007005808	interchain domain interface [polypeptide binding]; other site
561007005809	Qo binding site; other site
561007005810	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
561007005811	active site
561007005812	barstar interaction site; other site
561007005813	Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143
561007005814	putative RNAase interaction site [polypeptide binding]; other site
561007005815	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
561007005816	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
561007005817	heme binding site [chemical binding]; other site
561007005818	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
561007005819	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
561007005820	metal binding site 2 [ion binding]; metal-binding site
561007005821	putative DNA binding helix; other site
561007005822	metal binding site 1 [ion binding]; metal-binding site
561007005823	dimer interface [polypeptide binding]; other site
561007005824	structural Zn2+ binding site [ion binding]; other site
561007005825	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007005826	Helix-turn-helix domains; Region: HTH; cl00088
561007005827	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148
561007005828	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
561007005829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007005830	Coenzyme A binding pocket [chemical binding]; other site
561007005831	NlpC/P60 family; Region: NLPC_P60; cl11438
561007005832	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
561007005833	putative hydrophobic ligand binding site [chemical binding]; other site
561007005834	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
561007005835	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
561007005836	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007005837	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007005838	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
561007005839	putative hydrophobic ligand binding site [chemical binding]; other site
561007005840	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007005841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007005842	metabolite-proton symporter; Region: 2A0106; TIGR00883
561007005843	putative substrate translocation pore; other site
561007005844	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
561007005845	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
561007005846	active site
561007005847	non-prolyl cis peptide bond; other site
561007005848	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
561007005849	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
561007005850	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
561007005851	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007005852	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
561007005853	FAD binding pocket [chemical binding]; other site
561007005854	FAD binding motif [chemical binding]; other site
561007005855	catalytic residues [active]
561007005856	NAD binding pocket [chemical binding]; other site
561007005857	phosphate binding motif [ion binding]; other site
561007005858	beta-alpha-beta structure motif; other site
561007005859	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
561007005860	dimer interface [polypeptide binding]; other site
561007005861	active site
561007005862	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
561007005863	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
561007005864	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
561007005865	active site
561007005866	FMN binding site [chemical binding]; other site
561007005867	substrate binding site [chemical binding]; other site
561007005868	3Fe-4S cluster binding site [ion binding]; other site
561007005869	Glutamate synthase domain 3 [Amino acid transport and metabolism]; Region: GltB; COG0070
561007005870	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
561007005871	domain_subunit interface; other site
561007005872	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007005873	Ligand Binding Site [chemical binding]; other site
561007005874	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007005875	Ligand Binding Site [chemical binding]; other site
561007005876	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
561007005877	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
561007005878	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007005879	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
561007005880	FAD binding pocket [chemical binding]; other site
561007005881	FAD binding motif [chemical binding]; other site
561007005882	catalytic residues [active]
561007005883	NAD binding pocket [chemical binding]; other site
561007005884	phosphate binding motif [ion binding]; other site
561007005885	beta-alpha-beta structure motif; other site
561007005886	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
561007005887	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
561007005888	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007005889	active site
561007005890	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
561007005891	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007005892	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007005893	active site
561007005894	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
561007005895	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
561007005896	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
561007005897	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
561007005898	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007005899	active site
561007005900	DNA binding site [nucleotide binding]
561007005901	Int/Topo IB signature motif; other site
561007005902	FAD dependent oxidoreductase; Region: DAO; pfam01266
561007005903	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
561007005904	iron-sulfur cluster [ion binding]; other site
561007005905	[2Fe-2S] cluster binding site [ion binding]; other site
561007005906	putative phosphoketolase; Provisional; Region: PRK05261
561007005907	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
561007005908	TPP-binding site [chemical binding]; other site
561007005909	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
561007005910	XFP C-terminal domain; Region: XFP_C; pfam09363
561007005911	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
561007005912	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
561007005913	ligand binding site [chemical binding]; other site
561007005914	flexible hinge region; other site
561007005915	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
561007005916	putative switch regulator; other site
561007005917	non-specific DNA interactions [nucleotide binding]; other site
561007005918	DNA binding site [nucleotide binding]
561007005919	sequence specific DNA binding site [nucleotide binding]; other site
561007005920	putative cAMP binding site [chemical binding]; other site
561007005921	Flavin Reductases; Region: FlaRed; cl00801
561007005922	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
561007005923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007005924	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
561007005925	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007005926	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
561007005927	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007005928	DNA binding residues [nucleotide binding]
561007005929	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
561007005930	anti sigma factor interaction site; other site
561007005931	regulatory phosphorylation site [posttranslational modification]; other site
561007005932	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
561007005933	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
561007005934	active site
561007005935	metal binding site [ion binding]; metal-binding site
561007005936	Low affinity iron permease; Region: Iron_permease; cl12096
561007005937	Low affinity iron permease; Region: Iron_permease; cl12096
561007005938	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007005939	PAS fold; Region: PAS_3; pfam08447
561007005940	ANTAR domain; Region: ANTAR; cl04297
561007005941	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
561007005942	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007005943	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007005944	catalytic residue [active]
561007005945	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
561007005946	PhoU domain; Region: PhoU; pfam01895
561007005947	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
561007005948	LGFP repeat; Region: LGFP; pfam08310
561007005949	ChaB; Region: ChaB; cl01887
561007005950	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
561007005951	hydroperoxidase II; Provisional; Region: katE; PRK11249
561007005952	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
561007005953	tetramer interface [polypeptide binding]; other site
561007005954	heme binding pocket [chemical binding]; other site
561007005955	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
561007005956	domain interactions; other site
561007005957	GAF domain; Region: GAF_2; pfam13185
561007005958	ANTAR domain; Region: ANTAR; cl04297
561007005959	putative proline-specific permease; Provisional; Region: proY; PRK10580
561007005960	thiamine pyrophosphate protein; Provisional; Region: PRK08273
561007005961	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
561007005962	PYR/PP interface [polypeptide binding]; other site
561007005963	tetramer interface [polypeptide binding]; other site
561007005964	dimer interface [polypeptide binding]; other site
561007005965	TPP binding site [chemical binding]; other site
561007005966	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
561007005967	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
561007005968	TPP-binding site [chemical binding]; other site
561007005969	Secretory lipase; Region: LIP; pfam03583
561007005970	acyl-CoA synthetase; Validated; Region: PRK07788
561007005971	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005972	AMP-binding enzyme; Region: AMP-binding; cl15778
561007005973	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
561007005974	classical (c) SDRs; Region: SDR_c; cd05233
561007005975	NAD(P) binding site [chemical binding]; other site
561007005976	active site
561007005977	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007005978	Helix-turn-helix domains; Region: HTH; cl00088
561007005979	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007005980	Helix-turn-helix domains; Region: HTH; cl00088
561007005981	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
561007005982	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
561007005983	agmatine deiminase; Region: agmatine_aguA; TIGR03380
561007005984	Predicted amidohydrolase [General function prediction only]; Region: COG0388
561007005985	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
561007005986	active site
561007005987	catalytic triad [active]
561007005988	dimer interface [polypeptide binding]; other site
561007005989	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
561007005990	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
561007005991	active site
561007005992	Cupin domain; Region: Cupin_2; cl09118
561007005993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007005994	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
561007005995	homodimer interface [polypeptide binding]; other site
561007005996	putative substrate binding pocket [chemical binding]; other site
561007005997	diiron center [ion binding]; other site
561007005998	OpgC protein; Region: OpgC_C; cl00792
561007005999	Cellulose binding domain; Region: CBM_2; cl02709
561007006000	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
561007006001	Isochorismatase family; Region: Isochorismatase; pfam00857
561007006002	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
561007006003	catalytic triad [active]
561007006004	conserved cis-peptide bond; other site
561007006005	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
561007006006	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
561007006007	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
561007006008	LGFP repeat; Region: LGFP; pfam08310
561007006009	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
561007006010	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
561007006011	active site
561007006012	substrate-binding site [chemical binding]; other site
561007006013	metal-binding site [ion binding]
561007006014	GTP binding site [chemical binding]; other site
561007006015	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007006016	dimerization interface [polypeptide binding]; other site
561007006017	putative DNA binding site [nucleotide binding]; other site
561007006018	putative Zn2+ binding site [ion binding]; other site
561007006019	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
561007006020	active site clefts [active]
561007006021	zinc binding site [ion binding]; other site
561007006022	dimer interface [polypeptide binding]; other site
561007006023	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007006024	dimerization interface [polypeptide binding]; other site
561007006025	putative DNA binding site [nucleotide binding]; other site
561007006026	putative Zn2+ binding site [ion binding]; other site
561007006027	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
561007006028	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007006029	putative metal binding site [ion binding]; other site
561007006030	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
561007006031	Membrane transport protein; Region: Mem_trans; cl09117
561007006032	Low molecular weight phosphatase family; Region: LMWPc; cd00115
561007006033	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
561007006034	active site
561007006035	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
561007006036	Transport protein; Region: actII; TIGR00833
561007006037	Transport protein; Region: actII; TIGR00833
561007006038	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007006039	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
561007006040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006041	AMP-binding domain protein; Validated; Region: PRK07529
561007006042	AMP-binding enzyme; Region: AMP-binding; cl15778
561007006043	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007006044	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
561007006045	N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267
561007006046	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
561007006047	putative active site [active]
561007006048	putative metal binding site [ion binding]; other site
561007006049	YaeQ protein; Region: YaeQ; cl01913
561007006050	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
561007006051	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007006052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007006053	active site
561007006054	phosphorylation site [posttranslational modification]
561007006055	intermolecular recognition site; other site
561007006056	dimerization interface [polypeptide binding]; other site
561007006057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007006058	DNA binding site [nucleotide binding]
561007006059	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
561007006060	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007006061	dimer interface [polypeptide binding]; other site
561007006062	phosphorylation site [posttranslational modification]
561007006063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007006064	ATP binding site [chemical binding]; other site
561007006065	Mg2+ binding site [ion binding]; other site
561007006066	G-X-G motif; other site
561007006067	DJ-1 family protein; Region: not_thiJ; TIGR01383
561007006068	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
561007006069	conserved cys residue [active]
561007006070	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007006071	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007006072	Cupin domain; Region: Cupin_2; cl09118
561007006073	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
561007006074	PAS fold; Region: PAS_3; pfam08447
561007006075	putative active site [active]
561007006076	heme pocket [chemical binding]; other site
561007006077	ANTAR domain; Region: ANTAR; cl04297
561007006078	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
561007006079	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
561007006080	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
561007006081	active site
561007006082	NodB motif; other site
561007006083	metal binding site [ion binding]; metal-binding site
561007006084	catalytic site [active]
561007006085	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
561007006086	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007006087	Helix-turn-helix domains; Region: HTH; cl00088
561007006088	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007006089	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007006090	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
561007006091	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
561007006092	Spore germination protein; Region: Spore_permease; cl15802
561007006093	Spore germination protein; Region: Spore_permease; cl15802
561007006094	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007006095	dimerization interface [polypeptide binding]; other site
561007006096	putative DNA binding site [nucleotide binding]; other site
561007006097	putative Zn2+ binding site [ion binding]; other site
561007006098	Cation efflux family; Region: Cation_efflux; cl00316
561007006099	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007006100	putative DNA binding site [nucleotide binding]; other site
561007006101	putative Zn2+ binding site [ion binding]; other site
561007006102	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
561007006103	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007006104	active site
561007006105	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007006106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007006107	Helix-turn-helix domains; Region: HTH; cl00088
561007006108	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
561007006109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006110	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007006111	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007006112	acyl-CoA synthetase; Provisional; Region: PRK13388
561007006113	AMP-binding enzyme; Region: AMP-binding; cl15778
561007006114	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
561007006115	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
561007006116	inhibitor-cofactor binding pocket; inhibition site
561007006117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007006118	catalytic residue [active]
561007006119	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
561007006120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007006121	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006122	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
561007006123	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
561007006124	hypothetical protein; Provisional; Region: PRK06185
561007006125	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006126	DNA polymerase I; Provisional; Region: PRK05755
561007006127	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
561007006128	active site
561007006129	metal binding site 1 [ion binding]; metal-binding site
561007006130	putative 5' ssDNA interaction site; other site
561007006131	metal binding site 3; metal-binding site
561007006132	metal binding site 2 [ion binding]; metal-binding site
561007006133	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
561007006134	putative DNA binding site [nucleotide binding]; other site
561007006135	putative metal binding site [ion binding]; other site
561007006136	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
561007006137	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
561007006138	active site
561007006139	DNA binding site [nucleotide binding]
561007006140	catalytic site [active]
561007006141	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
561007006142	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007006143	active site
561007006144	metal binding site [ion binding]; metal-binding site
561007006145	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
561007006146	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
561007006147	D-pathway; other site
561007006148	Putative ubiquinol binding site [chemical binding]; other site
561007006149	Low-spin heme (heme b) binding site [chemical binding]; other site
561007006150	Putative water exit pathway; other site
561007006151	Binuclear center (heme o3/CuB) [ion binding]; other site
561007006152	K-pathway; other site
561007006153	Putative proton exit pathway; other site
561007006154	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
561007006155	DUF35 OB-fold domain; Region: DUF35; pfam01796
561007006156	lipid-transfer protein; Provisional; Region: PRK06059
561007006157	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007006158	active site
561007006159	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331
561007006160	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
561007006161	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
561007006162	Walker A/P-loop; other site
561007006163	ATP binding site [chemical binding]; other site
561007006164	Q-loop/lid; other site
561007006165	ABC transporter signature motif; other site
561007006166	Walker B; other site
561007006167	D-loop; other site
561007006168	H-loop/switch region; other site
561007006169	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
561007006170	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
561007006171	Walker A/P-loop; other site
561007006172	ATP binding site [chemical binding]; other site
561007006173	Q-loop/lid; other site
561007006174	ABC transporter signature motif; other site
561007006175	Walker B; other site
561007006176	D-loop; other site
561007006177	H-loop/switch region; other site
561007006178	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
561007006179	TM-ABC transporter signature motif; other site
561007006180	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
561007006181	TM-ABC transporter signature motif; other site
561007006182	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
561007006183	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
561007006184	dimerization interface [polypeptide binding]; other site
561007006185	ligand binding site [chemical binding]; other site
561007006186	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
561007006187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007006188	active site
561007006189	phosphorylation site [posttranslational modification]
561007006190	intermolecular recognition site; other site
561007006191	dimerization interface [polypeptide binding]; other site
561007006192	ANTAR domain; Region: ANTAR; cl04297
561007006193	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007006194	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
561007006195	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
561007006196	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
561007006197	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
561007006198	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
561007006199	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007006200	Walker A/P-loop; other site
561007006201	ATP binding site [chemical binding]; other site
561007006202	Q-loop/lid; other site
561007006203	ABC transporter signature motif; other site
561007006204	Walker B; other site
561007006205	D-loop; other site
561007006206	H-loop/switch region; other site
561007006207	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
561007006208	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007006209	Walker A/P-loop; other site
561007006210	ATP binding site [chemical binding]; other site
561007006211	Q-loop/lid; other site
561007006212	ABC transporter signature motif; other site
561007006213	Walker B; other site
561007006214	D-loop; other site
561007006215	H-loop/switch region; other site
561007006216	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
561007006217	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
561007006218	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
561007006219	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
561007006220	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
561007006221	active site
561007006222	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
561007006223	catalytic triad [active]
561007006224	dimer interface [polypeptide binding]; other site
561007006225	pyruvate kinase; Provisional; Region: PRK06247
561007006226	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
561007006227	domain interfaces; other site
561007006228	active site
561007006229	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
561007006230	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
561007006231	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
561007006232	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
561007006233	substrate binding site [chemical binding]; other site
561007006234	active site
561007006235	catalytic residues [active]
561007006236	heterodimer interface [polypeptide binding]; other site
561007006237	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
561007006238	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
561007006239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007006240	catalytic residue [active]
561007006241	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
561007006242	active site
561007006243	ribulose/triose binding site [chemical binding]; other site
561007006244	phosphate binding site [ion binding]; other site
561007006245	substrate (anthranilate) binding pocket [chemical binding]; other site
561007006246	product (indole) binding pocket [chemical binding]; other site
561007006247	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
561007006248	anthranilate synthase component I; Provisional; Region: PRK13571
561007006249	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
561007006250	chorismate binding enzyme; Region: Chorismate_bind; cl10555
561007006251	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007006252	Helix-turn-helix domains; Region: HTH; cl00088
561007006253	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007006254	Transport protein; Region: actII; TIGR00833
561007006255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006256	FAD dependent oxidoreductase; Region: DAO; pfam01266
561007006257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006258	active site
561007006259	Helix-turn-helix domains; Region: HTH; cl00088
561007006260	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007006261	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007006262	carbonic anhydrase; Provisional; Region: PRK15219
561007006263	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
561007006264	active site clefts [active]
561007006265	zinc binding site [ion binding]; other site
561007006266	dimer interface [polypeptide binding]; other site
561007006267	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
561007006268	Helix-turn-helix domains; Region: HTH; cl00088
561007006269	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
561007006270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006271	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006272	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
561007006273	HIT family signature motif; other site
561007006274	catalytic residue [active]
561007006275	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
561007006276	FMN binding site [chemical binding]; other site
561007006277	dimer interface [polypeptide binding]; other site
561007006278	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
561007006279	catalytic triad [active]
561007006280	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
561007006281	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
561007006282	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
561007006283	substrate binding site [chemical binding]; other site
561007006284	glutamase interaction surface [polypeptide binding]; other site
561007006285	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
561007006286	active site
561007006287	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
561007006288	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
561007006289	catalytic residues [active]
561007006290	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
561007006291	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
561007006292	putative active site [active]
561007006293	oxyanion strand; other site
561007006294	catalytic triad [active]
561007006295	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
561007006296	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
561007006297	putative active site pocket [active]
561007006298	4-fold oligomerization interface [polypeptide binding]; other site
561007006299	metal binding residues [ion binding]; metal-binding site
561007006300	3-fold/trimer interface [polypeptide binding]; other site
561007006301	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
561007006302	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007006303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007006304	homodimer interface [polypeptide binding]; other site
561007006305	catalytic residue [active]
561007006306	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
561007006307	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
561007006308	NAD binding site [chemical binding]; other site
561007006309	dimerization interface [polypeptide binding]; other site
561007006310	product binding site; other site
561007006311	substrate binding site [chemical binding]; other site
561007006312	zinc binding site [ion binding]; other site
561007006313	catalytic residues [active]
561007006314	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007006315	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
561007006316	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
561007006317	dimerization interface [polypeptide binding]; other site
561007006318	active site
561007006319	L-aspartate oxidase; Provisional; Region: PRK07804
561007006320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006321	Quinolinate synthetase A protein; Region: NadA; cl00420
561007006322	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
561007006323	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
561007006324	nudix motif; other site
561007006325	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
561007006326	Secretory lipase; Region: LIP; pfam03583
561007006327	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007006328	Helix-turn-helix domains; Region: HTH; cl00088
561007006329	hypothetical protein; Provisional; Region: PRK07588
561007006330	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006331	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007006332	Helix-turn-helix domains; Region: HTH; cl00088
561007006333	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007006334	dimerization interface [polypeptide binding]; other site
561007006335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006336	Predicted dehydrogenase [General function prediction only]; Region: COG0579
561007006337	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
561007006338	biotin synthase; Validated; Region: PRK06256
561007006339	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007006340	FeS/SAM binding site; other site
561007006341	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
561007006342	Helix-turn-helix domains; Region: HTH; cl00088
561007006343	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
561007006344	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007006345	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007006346	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
561007006347	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007006348	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007006349	catalytic residue [active]
561007006350	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
561007006351	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007006352	inhibitor-cofactor binding pocket; inhibition site
561007006353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007006354	catalytic residue [active]
561007006355	OpgC protein; Region: OpgC_C; cl00792
561007006356	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
561007006357	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
561007006358	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
561007006359	active site
561007006360	catalytic site [active]
561007006361	threonine dehydratase; Validated; Region: PRK08639
561007006362	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
561007006363	tetramer interface [polypeptide binding]; other site
561007006364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007006365	catalytic residue [active]
561007006366	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
561007006367	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007006368	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
561007006369	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
561007006370	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
561007006371	generic binding surface II; other site
561007006372	generic binding surface I; other site
561007006373	Predicted permeases [General function prediction only]; Region: RarD; COG2962
561007006374	EamA-like transporter family; Region: EamA; cl01037
561007006375	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
561007006376	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
561007006377	active site
561007006378	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
561007006379	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
561007006380	active site
561007006381	homotetramer interface [polypeptide binding]; other site
561007006382	homodimer interface [polypeptide binding]; other site
561007006383	DNA polymerase IV; Provisional; Region: PRK03348
561007006384	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
561007006385	active site
561007006386	DNA binding site [nucleotide binding]
561007006387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007006388	S-adenosylmethionine binding site [chemical binding]; other site
561007006389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007006390	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
561007006391	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
561007006392	HIGH motif; other site
561007006393	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
561007006394	active site
561007006395	KMSKS motif; other site
561007006396	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
561007006397	tRNA binding surface [nucleotide binding]; other site
561007006398	anticodon binding site; other site
561007006399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007006400	putative substrate translocation pore; other site
561007006401	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
561007006402	Helix-turn-helix domains; Region: HTH; cl00088
561007006403	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
561007006404	putative dimerization interface [polypeptide binding]; other site
561007006405	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
561007006406	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
561007006407	metal binding triad; other site
561007006408	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
561007006409	membrane ATPase/protein kinase; Provisional; Region: PRK09435
561007006410	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
561007006411	Walker A; other site
561007006412	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
561007006413	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
561007006414	active site
561007006415	substrate binding site [chemical binding]; other site
561007006416	coenzyme B12 binding site [chemical binding]; other site
561007006417	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
561007006418	B12 binding site [chemical binding]; other site
561007006419	cobalt ligand [ion binding]; other site
561007006420	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
561007006421	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
561007006422	heterodimer interface [polypeptide binding]; other site
561007006423	substrate interaction site [chemical binding]; other site
561007006424	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
561007006425	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
561007006426	DoxX; Region: DoxX; cl00976
561007006427	DoxX; Region: DoxX; cl00976
561007006428	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
561007006429	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
561007006430	Protein of unknown function (DUF1616); Region: DUF1616; cl01959
561007006431	MgtE intracellular N domain; Region: MgtE_N; cl15244
561007006432	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
561007006433	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
561007006434	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
561007006435	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
561007006436	ferrochelatase; Reviewed; Region: hemH; PRK00035
561007006437	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
561007006438	C-terminal domain interface [polypeptide binding]; other site
561007006439	active site
561007006440	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
561007006441	active site
561007006442	N-terminal domain interface [polypeptide binding]; other site
561007006443	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
561007006444	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
561007006445	NAD binding site [chemical binding]; other site
561007006446	homotetramer interface [polypeptide binding]; other site
561007006447	homodimer interface [polypeptide binding]; other site
561007006448	substrate binding site [chemical binding]; other site
561007006449	active site
561007006450	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
561007006451	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
561007006452	NAD(P) binding site [chemical binding]; other site
561007006453	homotetramer interface [polypeptide binding]; other site
561007006454	homodimer interface [polypeptide binding]; other site
561007006455	active site
561007006456	hypothetical protein; Provisional; Region: PRK13685
561007006457	Aerotolerance regulator N-terminal; Region: BatA; cl06567
561007006458	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007006459	metal ion-dependent adhesion site (MIDAS); other site
561007006460	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
561007006461	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
561007006462	MoxR-like ATPases [General function prediction only]; Region: COG0714
561007006463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007006464	Walker A motif; other site
561007006465	ATP binding site [chemical binding]; other site
561007006466	Walker B motif; other site
561007006467	arginine finger; other site
561007006468	NlpC/P60 family; Region: NLPC_P60; cl11438
561007006469	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
561007006470	NlpC/P60 family; Region: NLPC_P60; cl11438
561007006471	aconitate hydratase; Validated; Region: PRK09277
561007006472	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
561007006473	substrate binding site [chemical binding]; other site
561007006474	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
561007006475	ligand binding site [chemical binding]; other site
561007006476	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
561007006477	substrate binding site [chemical binding]; other site
561007006478	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007006479	Helix-turn-helix domains; Region: HTH; cl00088
561007006480	Helix-turn-helix domains; Region: HTH; cl00088
561007006481	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
561007006482	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007006483	Walker A/P-loop; other site
561007006484	ATP binding site [chemical binding]; other site
561007006485	Q-loop/lid; other site
561007006486	ABC transporter signature motif; other site
561007006487	Walker B; other site
561007006488	D-loop; other site
561007006489	H-loop/switch region; other site
561007006490	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
561007006491	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007006492	enoyl-CoA hydratase; Provisional; Region: PRK06688
561007006493	substrate binding site [chemical binding]; other site
561007006494	oxyanion hole (OAH) forming residues; other site
561007006495	trimer interface [polypeptide binding]; other site
561007006496	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
561007006497	catalytic residues [active]
561007006498	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
561007006499	putative active site [active]
561007006500	putative FMN binding site [chemical binding]; other site
561007006501	putative substrate binding site [chemical binding]; other site
561007006502	putative catalytic residue [active]
561007006503	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
561007006504	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007006505	Coenzyme A binding pocket [chemical binding]; other site
561007006506	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
561007006507	Domain of unknown function DUF59; Region: DUF59; cl00941
561007006508	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
561007006509	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
561007006510	trimerization site [polypeptide binding]; other site
561007006511	active site
561007006512	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
561007006513	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
561007006514	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007006515	catalytic residue [active]
561007006516	FeS assembly ATPase SufC; Region: sufC; TIGR01978
561007006517	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
561007006518	Walker A/P-loop; other site
561007006519	ATP binding site [chemical binding]; other site
561007006520	Q-loop/lid; other site
561007006521	ABC transporter signature motif; other site
561007006522	Walker B; other site
561007006523	D-loop; other site
561007006524	H-loop/switch region; other site
561007006525	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
561007006526	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
561007006527	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
561007006528	FeS assembly protein SufB; Region: sufB; TIGR01980
561007006529	Predicted transcriptional regulator [Transcription]; Region: COG2345
561007006530	Helix-turn-helix domains; Region: HTH; cl00088
561007006531	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
561007006532	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
561007006533	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
561007006534	Walker A/P-loop; other site
561007006535	ATP binding site [chemical binding]; other site
561007006536	Q-loop/lid; other site
561007006537	ABC transporter signature motif; other site
561007006538	Walker B; other site
561007006539	D-loop; other site
561007006540	H-loop/switch region; other site
561007006541	ABC-2 type transporter; Region: ABC2_membrane; cl11417
561007006542	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
561007006543	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007006544	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
561007006545	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
561007006546	NADP binding site [chemical binding]; other site
561007006547	dimer interface [polypeptide binding]; other site
561007006548	UbiA prenyltransferase family; Region: UbiA; cl00337
561007006549	transketolase; Reviewed; Region: PRK05899
561007006550	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
561007006551	TPP-binding site [chemical binding]; other site
561007006552	dimer interface [polypeptide binding]; other site
561007006553	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
561007006554	PYR/PP interface [polypeptide binding]; other site
561007006555	dimer interface [polypeptide binding]; other site
561007006556	TPP binding site [chemical binding]; other site
561007006557	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
561007006558	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
561007006559	putative active site [active]
561007006560	transaldolase; Provisional; Region: PRK03903
561007006561	catalytic residue [active]
561007006562	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
561007006563	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
561007006564	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
561007006565	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
561007006566	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
561007006567	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
561007006568	putative active site [active]
561007006569	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007006570	Helix-turn-helix domains; Region: HTH; cl00088
561007006571	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
561007006572	dimerization interface [polypeptide binding]; other site
561007006573	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
561007006574	CoA-transferase family III; Region: CoA_transf_3; pfam02515
561007006575	aromatic acid decarboxylase; Validated; Region: PRK05920
561007006576	Flavoprotein; Region: Flavoprotein; cl08021
561007006577	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
561007006578	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
561007006579	Subunit I/III interface [polypeptide binding]; other site
561007006580	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
561007006581	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
561007006582	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
561007006583	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
561007006584	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
561007006585	substrate binding site [chemical binding]; other site
561007006586	dimer interface [polypeptide binding]; other site
561007006587	catalytic triad [active]
561007006588	Phosphoglycerate kinase; Region: PGK; pfam00162
561007006589	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
561007006590	substrate binding site [chemical binding]; other site
561007006591	hinge regions; other site
561007006592	ADP binding site [chemical binding]; other site
561007006593	catalytic site [active]
561007006594	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006595	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
561007006596	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
561007006597	H+ Antiporter protein; Region: 2A0121; TIGR00900
561007006598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007006599	putative substrate translocation pore; other site
561007006600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
561007006601	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
561007006602	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
561007006603	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
561007006604	phosphate binding site [ion binding]; other site
561007006605	putative substrate binding pocket [chemical binding]; other site
561007006606	dimer interface [polypeptide binding]; other site
561007006607	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
561007006608	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
561007006609	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
561007006610	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
561007006611	GIY-YIG motif/motif A; other site
561007006612	active site
561007006613	catalytic site [active]
561007006614	putative DNA binding site [nucleotide binding]; other site
561007006615	metal binding site [ion binding]; metal-binding site
561007006616	UvrB/uvrC motif; Region: UVR; pfam02151
561007006617	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
561007006618	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
561007006619	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
561007006620	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007006621	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
561007006622	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
561007006623	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
561007006624	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
561007006625	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
561007006626	ethanolamine permease; Region: 2A0305; TIGR00908
561007006627	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
561007006628	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007006629	NAD(P) binding site [chemical binding]; other site
561007006630	catalytic residues [active]
561007006631	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
561007006632	Helix-turn-helix domains; Region: HTH; cl00088
561007006633	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
561007006634	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
561007006635	homopentamer interface [polypeptide binding]; other site
561007006636	active site
561007006637	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
561007006638	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
561007006639	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
561007006640	dimerization interface [polypeptide binding]; other site
561007006641	active site
561007006642	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
561007006643	Lumazine binding domain; Region: Lum_binding; pfam00677
561007006644	Lumazine binding domain; Region: Lum_binding; pfam00677
561007006645	MspA; Region: MspA; pfam09203
561007006646	MspA; Region: MspA; pfam09203
561007006647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
561007006648	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
561007006649	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
561007006650	Walker A/P-loop; other site
561007006651	ATP binding site [chemical binding]; other site
561007006652	Q-loop/lid; other site
561007006653	ABC transporter signature motif; other site
561007006654	Walker B; other site
561007006655	D-loop; other site
561007006656	H-loop/switch region; other site
561007006657	NIL domain; Region: NIL; cl09633
561007006658	NMT1-like family; Region: NMT1_2; cl15260
561007006659	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
561007006660	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
561007006661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007006662	putative substrate translocation pore; other site
561007006663	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
561007006664	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
561007006665	catalytic motif [active]
561007006666	Zn binding site [ion binding]; other site
561007006667	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
561007006668	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
561007006669	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
561007006670	substrate binding site [chemical binding]; other site
561007006671	hexamer interface [polypeptide binding]; other site
561007006672	metal binding site [ion binding]; metal-binding site
561007006673	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
561007006674	putative RNA binding site [nucleotide binding]; other site
561007006675	16S rRNA methyltransferase B; Provisional; Region: PRK14902
561007006676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007006677	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
561007006678	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
561007006679	putative active site [active]
561007006680	substrate binding site [chemical binding]; other site
561007006681	putative cosubstrate binding site; other site
561007006682	catalytic site [active]
561007006683	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
561007006684	substrate binding site [chemical binding]; other site
561007006685	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007006686	Helix-turn-helix domains; Region: HTH; cl00088
561007006687	primosome assembly protein PriA; Provisional; Region: PRK14873
561007006688	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007006689	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007006690	substrate binding pocket [chemical binding]; other site
561007006691	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007006692	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
561007006693	Na binding site [ion binding]; other site
561007006694	putative substrate binding site [chemical binding]; other site
561007006695	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
561007006696	F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842
561007006697	phenylhydantoinase; Validated; Region: PRK08323
561007006698	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
561007006699	tetramer interface [polypeptide binding]; other site
561007006700	active site
561007006701	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
561007006702	N-carbamolyputrescine amidase; Region: PLN02747
561007006703	active site
561007006704	catalytic triad [active]
561007006705	dimer interface [polypeptide binding]; other site
561007006706	Phospholipid methyltransferase; Region: PEMT; cl00763
561007006707	S-adenosylmethionine synthetase; Validated; Region: PRK05250
561007006708	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
561007006709	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
561007006710	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
561007006711	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
561007006712	Flavoprotein; Region: Flavoprotein; cl08021
561007006713	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
561007006714	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
561007006715	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
561007006716	catalytic site [active]
561007006717	Acyltransferase family; Region: Acyl_transf_3; pfam01757
561007006718	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
561007006719	active site
561007006720	dimer interface [polypeptide binding]; other site
561007006721	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
561007006722	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
561007006723	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007006724	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
561007006725	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
561007006726	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007006727	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
561007006728	IMP binding site; other site
561007006729	dimer interface [polypeptide binding]; other site
561007006730	interdomain contacts; other site
561007006731	partial ornithine binding site; other site
561007006732	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
561007006733	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
561007006734	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
561007006735	catalytic site [active]
561007006736	subunit interface [polypeptide binding]; other site
561007006737	dihydroorotase; Validated; Region: pyrC; PRK09357
561007006738	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007006739	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
561007006740	active site
561007006741	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
561007006742	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
561007006743	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006744	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
561007006745	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007006746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007006747	S-adenosylmethionine binding site [chemical binding]; other site
561007006748	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007006749	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
561007006750	elongation factor P; Validated; Region: PRK00529
561007006751	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
561007006752	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
561007006753	RNA binding site [nucleotide binding]; other site
561007006754	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
561007006755	RNA binding site [nucleotide binding]; other site
561007006756	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
561007006757	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
561007006758	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
561007006759	active site
561007006760	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
561007006761	trimer interface [polypeptide binding]; other site
561007006762	active site
561007006763	dimer interface [polypeptide binding]; other site
561007006764	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
561007006765	active site
561007006766	dimer interface [polypeptide binding]; other site
561007006767	metal binding site [ion binding]; metal-binding site
561007006768	shikimate kinase; Reviewed; Region: aroK; PRK00131
561007006769	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
561007006770	ADP binding site [chemical binding]; other site
561007006771	magnesium binding site [ion binding]; other site
561007006772	putative shikimate binding site; other site
561007006773	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
561007006774	Tetramer interface [polypeptide binding]; other site
561007006775	active site
561007006776	FMN-binding site [chemical binding]; other site
561007006777	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
561007006778	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
561007006779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007006780	S-adenosylmethionine binding site [chemical binding]; other site
561007006781	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007006782	Helix-turn-helix domains; Region: HTH; cl00088
561007006783	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007006784	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
561007006785	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
561007006786	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
561007006787	shikimate binding site; other site
561007006788	NAD(P) binding site [chemical binding]; other site
561007006789	YceG-like family; Region: YceG; pfam02618
561007006790	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
561007006791	dimerization interface [polypeptide binding]; other site
561007006792	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
561007006793	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
561007006794	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
561007006795	motif 1; other site
561007006796	active site
561007006797	motif 2; other site
561007006798	motif 3; other site
561007006799	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
561007006800	DHHA1 domain; Region: DHHA1; pfam02272
561007006801	recombination factor protein RarA; Reviewed; Region: PRK13342
561007006802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007006803	Walker A motif; other site
561007006804	ATP binding site [chemical binding]; other site
561007006805	Walker B motif; other site
561007006806	arginine finger; other site
561007006807	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
561007006808	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
561007006809	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007006810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
561007006811	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
561007006812	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
561007006813	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
561007006814	Uncharacterized conserved protein [Function unknown]; Region: COG2308
561007006815	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
561007006816	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
561007006817	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
561007006818	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
561007006819	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
561007006820	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
561007006821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
561007006822	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007006823	Predicted permease; Region: DUF318; pfam03773
561007006824	Predicted permeases [General function prediction only]; Region: COG0701
561007006825	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
561007006826	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
561007006827	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007006828	motif II; other site
561007006829	Domain of unknown function (DUF389); Region: DUF389; cl00781
561007006830	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
561007006831	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
561007006832	dimer interface [polypeptide binding]; other site
561007006833	anticodon binding site; other site
561007006834	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
561007006835	homodimer interface [polypeptide binding]; other site
561007006836	motif 1; other site
561007006837	active site
561007006838	motif 2; other site
561007006839	GAD domain; Region: GAD; pfam02938
561007006840	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
561007006841	active site
561007006842	motif 3; other site
561007006843	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
561007006844	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007006845	substrate binding pocket [chemical binding]; other site
561007006846	catalytic triad [active]
561007006847	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
561007006848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007006849	Radical SAM superfamily; Region: Radical_SAM; pfam04055
561007006850	FeS/SAM binding site; other site
561007006851	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007006852	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
561007006853	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
561007006854	putative active site pocket [active]
561007006855	dimerization interface [polypeptide binding]; other site
561007006856	putative catalytic residue [active]
561007006857	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
561007006858	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
561007006859	dimer interface [polypeptide binding]; other site
561007006860	motif 1; other site
561007006861	active site
561007006862	motif 2; other site
561007006863	motif 3; other site
561007006864	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
561007006865	anticodon binding site; other site
561007006866	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007006867	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
561007006868	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
561007006869	active site
561007006870	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007006871	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
561007006872	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007006873	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
561007006874	synthetase active site [active]
561007006875	NTP binding site [chemical binding]; other site
561007006876	metal binding site [ion binding]; metal-binding site
561007006877	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
561007006878	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
561007006879	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007006880	active site
561007006881	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
561007006882	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
561007006883	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
561007006884	Protein export membrane protein; Region: SecD_SecF; cl14618
561007006885	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
561007006886	Protein export membrane protein; Region: SecD_SecF; cl14618
561007006887	Preprotein translocase subunit; Region: YajC; cl00806
561007006888	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
561007006889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007006890	Walker A motif; other site
561007006891	ATP binding site [chemical binding]; other site
561007006892	Walker B motif; other site
561007006893	arginine finger; other site
561007006894	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
561007006895	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
561007006896	RuvA N terminal domain; Region: RuvA_N; pfam01330
561007006897	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
561007006898	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
561007006899	putative DNA-binding cleft [nucleotide binding]; other site
561007006900	dimer interface [polypeptide binding]; other site
561007006901	active site
561007006902	calcium/proton exchanger (cax); Region: cax; TIGR00378
561007006903	Transcriptional regulator; Region: Transcrip_reg; cl00361
561007006904	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
561007006905	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143
561007006906	predicted active site [active]
561007006907	catalytic triad [active]
561007006908	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
561007006909	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
561007006910	active site
561007006911	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
561007006912	catalytic triad [active]
561007006913	dimer interface [polypeptide binding]; other site
561007006914	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
561007006915	active site
561007006916	multimer interface [polypeptide binding]; other site
561007006917	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
561007006918	nudix motif; other site
561007006919	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
561007006920	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
561007006921	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
561007006922	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
561007006923	putative acyl-acceptor binding pocket; other site
561007006924	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
561007006925	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
561007006926	nucleotide binding site/active site [active]
561007006927	HIT family signature motif; other site
561007006928	catalytic residue [active]
561007006929	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
561007006930	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
561007006931	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
561007006932	active site
561007006933	dimer interface [polypeptide binding]; other site
561007006934	motif 1; other site
561007006935	motif 2; other site
561007006936	motif 3; other site
561007006937	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
561007006938	anticodon binding site; other site
561007006939	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
561007006940	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
561007006941	conserved cys residue [active]
561007006942	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007006943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007006944	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
561007006945	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
561007006946	conserved cys residue [active]
561007006947	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007006948	CoenzymeA binding site [chemical binding]; other site
561007006949	subunit interaction site [polypeptide binding]; other site
561007006950	PHB binding site; other site
561007006951	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
561007006952	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007006953	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
561007006954	AMP-binding enzyme; Region: AMP-binding; cl15778
561007006955	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
561007006956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007006957	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
561007006958	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
561007006959	homotrimer interaction site [polypeptide binding]; other site
561007006960	putative active site [active]
561007006961	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007006962	active site
561007006963	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
561007006964	intersubunit interface [polypeptide binding]; other site
561007006965	active site
561007006966	Zn2+ binding site [ion binding]; other site
561007006967	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007006968	Helix-turn-helix domains; Region: HTH; cl00088
561007006969	L-asparagine permease; Provisional; Region: PRK15049
561007006970	Spore germination protein; Region: Spore_permease; cl15802
561007006971	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
561007006972	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
561007006973	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
561007006974	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
561007006975	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007006976	CAAX protease self-immunity; Region: Abi; cl00558
561007006977	Predicted amidohydrolase [General function prediction only]; Region: COG0388
561007006978	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
561007006979	putative active site [active]
561007006980	catalytic triad [active]
561007006981	putative dimer interface [polypeptide binding]; other site
561007006982	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
561007006983	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
561007006984	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
561007006985	XdhC Rossmann domain; Region: XdhC_C; pfam13478
561007006986	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
561007006987	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007006988	catalytic loop [active]
561007006989	iron binding site [ion binding]; other site
561007006990	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
561007006991	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
561007006992	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
561007006993	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
561007006994	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
561007006995	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
561007006996	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
561007006997	active site
561007006998	putative substrate binding pocket [chemical binding]; other site
561007006999	guanine deaminase; Provisional; Region: PRK09228
561007007000	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007007001	active site
561007007002	urate oxidase; Region: urate_oxi; TIGR03383
561007007003	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
561007007004	active site
561007007005	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
561007007006	active site
561007007007	homotetramer interface [polypeptide binding]; other site
561007007008	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
561007007009	xanthine permease; Region: pbuX; TIGR03173
561007007010	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
561007007011	Transcriptional regulators [Transcription]; Region: FadR; COG2186
561007007012	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007007013	DNA-binding site [nucleotide binding]; DNA binding site
561007007014	FCD domain; Region: FCD; cl11656
561007007015	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
561007007016	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
561007007017	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
561007007018	active site
561007007019	catalytic site [active]
561007007020	tetramer interface [polypeptide binding]; other site
561007007021	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
561007007022	Na binding site [ion binding]; other site
561007007023	putative substrate binding site [chemical binding]; other site
561007007024	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
561007007025	metal-binding site
561007007026	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
561007007027	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
561007007028	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
561007007029	allantoicase; Provisional; Region: PRK13257
561007007030	Allantoicase repeat; Region: Allantoicase; pfam03561
561007007031	Allantoicase repeat; Region: Allantoicase; pfam03561
561007007032	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
561007007033	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
561007007034	active site
561007007035	catalytic tetrad [active]
561007007036	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
561007007037	short chain dehydrogenase; Provisional; Region: PRK06181
561007007038	classical (c) SDRs; Region: SDR_c; cd05233
561007007039	NAD(P) binding site [chemical binding]; other site
561007007040	active site
561007007041	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
561007007042	mce related protein; Region: MCE; pfam02470
561007007043	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007007044	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007007045	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007007046	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007007047	active site
561007007048	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
561007007049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007050	NAD(P) binding site [chemical binding]; other site
561007007051	active site
561007007052	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
561007007053	active site
561007007054	catalytic site [active]
561007007055	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007007056	active site 2 [active]
561007007057	active site 1 [active]
561007007058	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
561007007059	hydrophobic ligand binding site; other site
561007007060	lipid-transfer protein; Provisional; Region: PRK08256
561007007061	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007007062	active site
561007007063	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007064	Helix-turn-helix domains; Region: HTH; cl00088
561007007065	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
561007007066	Peptidase family M48; Region: Peptidase_M48; cl12018
561007007067	GatB domain; Region: GatB_Yqey; cl11497
561007007068	Helix-turn-helix domains; Region: HTH; cl00088
561007007069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007007070	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
561007007071	putative substrate translocation pore; other site
561007007072	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007007073	Methyltransferase domain; Region: Methyltransf_31; pfam13847
561007007074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007007075	S-adenosylmethionine binding site [chemical binding]; other site
561007007076	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
561007007077	AMP-binding enzyme; Region: AMP-binding; cl15778
561007007078	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
561007007079	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
561007007080	putative NAD(P) binding site [chemical binding]; other site
561007007081	active site
561007007082	putative substrate binding site [chemical binding]; other site
561007007083	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
561007007084	AMP-binding enzyme; Region: AMP-binding; cl15778
561007007085	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
561007007086	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
561007007087	putative NAD(P) binding site [chemical binding]; other site
561007007088	active site
561007007089	putative substrate binding site [chemical binding]; other site
561007007090	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007007091	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
561007007092	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007007093	active site
561007007094	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007007095	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007007096	catalytic loop [active]
561007007097	iron binding site [ion binding]; other site
561007007098	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007007099	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007007100	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007101	Helix-turn-helix domains; Region: HTH; cl00088
561007007102	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007007103	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007007104	hydrophobic ligand binding site; other site
561007007105	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
561007007106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007107	NAD(P) binding site [chemical binding]; other site
561007007108	active site
561007007109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007007110	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
561007007111	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007112	Walker A motif; other site
561007007113	ATP binding site [chemical binding]; other site
561007007114	Walker B motif; other site
561007007115	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
561007007116	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
561007007117	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007007118	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
561007007119	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
561007007120	SelR domain; Region: SelR; pfam01641
561007007121	Flagellar L-ring protein; Region: FlgH; cl00905
561007007122	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
561007007123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007007124	putative substrate translocation pore; other site
561007007125	Chlorite dismutase; Region: Chlor_dismutase; cl01280
561007007126	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
561007007127	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007128	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
561007007129	substrate binding site [chemical binding]; other site
561007007130	active site
561007007131	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
561007007132	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
561007007133	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
561007007134	catalytic site [active]
561007007135	putative active site [active]
561007007136	putative substrate binding site [chemical binding]; other site
561007007137	HRDC domain; Region: HRDC; cl02578
561007007138	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
561007007139	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
561007007140	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
561007007141	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
561007007142	TPP-binding site; other site
561007007143	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
561007007144	PYR/PP interface [polypeptide binding]; other site
561007007145	dimer interface [polypeptide binding]; other site
561007007146	TPP binding site [chemical binding]; other site
561007007147	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
561007007148	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
561007007149	TRAM domain; Region: TRAM; cl01282
561007007150	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
561007007151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007007152	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007007153	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
561007007154	K+ potassium transporter; Region: K_trans; cl15781
561007007155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007156	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
561007007157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007158	NAD(P) binding site [chemical binding]; other site
561007007159	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
561007007160	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
561007007161	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
561007007162	generic binding surface II; other site
561007007163	ssDNA binding site; other site
561007007164	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007007165	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
561007007166	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007007167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007007168	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
561007007169	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007170	NAD(P) binding site [chemical binding]; other site
561007007171	active site
561007007172	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007007173	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
561007007174	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
561007007175	trimer interface [polypeptide binding]; other site
561007007176	active site
561007007177	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
561007007178	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
561007007179	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
561007007180	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
561007007181	active site
561007007182	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
561007007183	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
561007007184	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007007185	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
561007007186	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007007187	DNA binding residues [nucleotide binding]
561007007188	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
561007007189	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
561007007190	DNA binding site [nucleotide binding]
561007007191	active site
561007007192	Predicted membrane protein [Function unknown]; Region: COG3918
561007007193	mercuric reductase; Validated; Region: PRK06370
561007007194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007007196	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007007197	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
561007007198	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
561007007199	active site
561007007200	metal binding site [ion binding]; metal-binding site
561007007201	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
561007007202	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007007203	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
561007007204	homotrimer interaction site [polypeptide binding]; other site
561007007205	putative active site [active]
561007007206	Transcriptional regulators [Transcription]; Region: FadR; COG2186
561007007207	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007007208	DNA-binding site [nucleotide binding]; DNA binding site
561007007209	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
561007007210	Protein of unknown function (DUF692); Region: DUF692; cl01263
561007007211	Protein of unknown function (DUF952); Region: DUF952; cl01393
561007007212	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
561007007213	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
561007007214	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
561007007215	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
561007007216	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
561007007217	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007007218	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
561007007219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007007220	DNA binding residues [nucleotide binding]
561007007221	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
561007007222	Helix-turn-helix domains; Region: HTH; cl00088
561007007223	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
561007007224	FeoA domain; Region: FeoA; cl00838
561007007225	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
561007007226	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
561007007227	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
561007007228	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007229	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007007230	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007007231	PAC2 family; Region: PAC2; cl00847
561007007232	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007007233	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007007234	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
561007007235	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
561007007236	ATP cone domain; Region: ATP-cone; pfam03477
561007007237	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
561007007238	LexA repressor; Validated; Region: PRK00215
561007007239	Helix-turn-helix domains; Region: HTH; cl00088
561007007240	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
561007007241	Catalytic site [active]
561007007242	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
561007007243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007007244	Coenzyme A binding pocket [chemical binding]; other site
561007007245	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007007246	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007007247	active site
561007007248	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
561007007249	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
561007007250	molybdopterin cofactor binding site [chemical binding]; other site
561007007251	substrate binding site [chemical binding]; other site
561007007252	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
561007007253	molybdopterin cofactor binding site; other site
561007007254	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
561007007255	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
561007007256	HflX GTPase family; Region: HflX; cd01878
561007007257	G1 box; other site
561007007258	GTP/Mg2+ binding site [chemical binding]; other site
561007007259	Switch I region; other site
561007007260	G2 box; other site
561007007261	G3 box; other site
561007007262	Switch II region; other site
561007007263	G4 box; other site
561007007264	G5 box; other site
561007007265	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
561007007266	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
561007007267	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
561007007268	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007269	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
561007007270	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
561007007271	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
561007007272	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
561007007273	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
561007007274	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
561007007275	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
561007007276	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007007277	FeS/SAM binding site; other site
561007007278	Dehydratase family; Region: ILVD_EDD; cl00340
561007007279	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
561007007280	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
561007007281	Walker A/P-loop; other site
561007007282	ATP binding site [chemical binding]; other site
561007007283	Q-loop/lid; other site
561007007284	ABC transporter signature motif; other site
561007007285	Walker B; other site
561007007286	D-loop; other site
561007007287	H-loop/switch region; other site
561007007288	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
561007007289	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
561007007290	substrate binding pocket [chemical binding]; other site
561007007291	membrane-bound complex binding site; other site
561007007292	hinge residues; other site
561007007293	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
561007007294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007007295	dimer interface [polypeptide binding]; other site
561007007296	conserved gate region; other site
561007007297	putative PBP binding loops; other site
561007007298	ABC-ATPase subunit interface; other site
561007007299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007007300	dimer interface [polypeptide binding]; other site
561007007301	conserved gate region; other site
561007007302	putative PBP binding loops; other site
561007007303	ABC-ATPase subunit interface; other site
561007007304	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
561007007305	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007007306	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007007307	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007007308	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007007309	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
561007007310	active site
561007007311	metal binding site [ion binding]; metal-binding site
561007007312	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
561007007313	CGNR zinc finger; Region: zf-CGNR; pfam11706
561007007314	RecX family; Region: RecX; cl00936
561007007315	recombinase A; Provisional; Region: recA; PRK09354
561007007316	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
561007007317	hexamer interface [polypeptide binding]; other site
561007007318	Walker A motif; other site
561007007319	ATP binding site [chemical binding]; other site
561007007320	Walker B motif; other site
561007007321	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
561007007322	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
561007007323	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
561007007324	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007007325	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007007326	PspA/IM30 family; Region: PspA_IM30; pfam04012
561007007327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007007328	non-specific DNA binding site [nucleotide binding]; other site
561007007329	salt bridge; other site
561007007330	sequence-specific DNA binding site [nucleotide binding]; other site
561007007331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007007332	short chain dehydrogenase; Provisional; Region: PRK06197
561007007333	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
561007007334	putative NAD(P) binding site [chemical binding]; other site
561007007335	active site
561007007336	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
561007007337	bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308
561007007338	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007007339	Coenzyme A binding pocket [chemical binding]; other site
561007007340	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007007341	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007342	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
561007007343	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007007344	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007345	Helix-turn-helix domains; Region: HTH; cl00088
561007007346	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
561007007347	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
561007007348	classical (c) SDRs; Region: SDR_c; cd05233
561007007349	NAD(P) binding site [chemical binding]; other site
561007007350	active site
561007007351	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007007352	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
561007007353	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007007354	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
561007007355	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
561007007356	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
561007007357	dimer interface [polypeptide binding]; other site
561007007358	active site
561007007359	catalytic residue [active]
561007007360	Thymidylate synthase complementing protein; Region: Thy1; cl03630
561007007361	YceI-like domain; Region: YceI; cl01001
561007007362	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
561007007363	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
561007007364	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
561007007365	catalytic residues [active]
561007007366	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
561007007367	folate binding site [chemical binding]; other site
561007007368	NADP+ binding site [chemical binding]; other site
561007007369	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
561007007370	dimerization interface [polypeptide binding]; other site
561007007371	active site
561007007372	acyltransferase PapA5; Provisional; Region: PRK09294
561007007373	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007007374	dihydrodipicolinate reductase; Provisional; Region: PRK00048
561007007375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007376	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
561007007377	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
561007007378	Sulfate transporter family; Region: Sulfate_transp; cl15842
561007007379	Sulfate transporter family; Region: Sulfate_transp; cl15842
561007007380	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
561007007381	active site clefts [active]
561007007382	zinc binding site [ion binding]; other site
561007007383	dimer interface [polypeptide binding]; other site
561007007384	Helix-turn-helix domains; Region: HTH; cl00088
561007007385	AsnC family; Region: AsnC_trans_reg; pfam01037
561007007386	alanine dehydrogenase; Region: alaDH; TIGR00518
561007007387	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
561007007388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007389	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007007390	hypothetical protein; Provisional; Region: PRK06194
561007007391	classical (c) SDRs; Region: SDR_c; cd05233
561007007392	NAD(P) binding site [chemical binding]; other site
561007007393	active site
561007007394	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
561007007395	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
561007007396	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
561007007397	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
561007007398	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
561007007399	oligomer interface [polypeptide binding]; other site
561007007400	RNA binding site [nucleotide binding]; other site
561007007401	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
561007007402	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
561007007403	RNase E interface [polypeptide binding]; other site
561007007404	trimer interface [polypeptide binding]; other site
561007007405	active site
561007007406	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
561007007407	putative nucleic acid binding region [nucleotide binding]; other site
561007007408	G-X-X-G motif; other site
561007007409	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
561007007410	RNA binding site [nucleotide binding]; other site
561007007411	domain interface; other site
561007007412	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
561007007413	16S/18S rRNA binding site [nucleotide binding]; other site
561007007414	S13e-L30e interaction site [polypeptide binding]; other site
561007007415	25S rRNA binding site [nucleotide binding]; other site
561007007416	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
561007007417	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
561007007418	active site
561007007419	Riboflavin kinase; Region: Flavokinase; cl03312
561007007420	Helix-turn-helix domains; Region: HTH; cl00088
561007007421	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
561007007422	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
561007007423	FeoA domain; Region: FeoA; cl00838
561007007424	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
561007007425	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007007426	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007007427	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
561007007428	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
561007007429	RNA binding site [nucleotide binding]; other site
561007007430	active site
561007007431	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
561007007432	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
561007007433	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
561007007434	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
561007007435	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
561007007436	active site
561007007437	metal binding site [ion binding]; metal-binding site
561007007438	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007007439	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007007440	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
561007007441	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007007442	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007007443	active site
561007007444	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007007445	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007007446	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007007447	active site
561007007448	enoyl-CoA hydratase; Provisional; Region: PRK06190
561007007449	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007007450	substrate binding site [chemical binding]; other site
561007007451	oxyanion hole (OAH) forming residues; other site
561007007452	trimer interface [polypeptide binding]; other site
561007007453	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
561007007454	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
561007007455	putative efflux protein, MATE family; Region: matE; TIGR00797
561007007456	MatE; Region: MatE; cl10513
561007007457	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
561007007458	DHH family; Region: DHH; pfam01368
561007007459	Ribosome-binding factor A; Region: RBFA; cl00542
561007007460	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
561007007461	translation initiation factor IF-2; Region: IF-2; TIGR00487
561007007462	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
561007007463	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
561007007464	G1 box; other site
561007007465	putative GEF interaction site [polypeptide binding]; other site
561007007466	GTP/Mg2+ binding site [chemical binding]; other site
561007007467	Switch I region; other site
561007007468	G2 box; other site
561007007469	G3 box; other site
561007007470	Switch II region; other site
561007007471	G4 box; other site
561007007472	G5 box; other site
561007007473	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
561007007474	Translation-initiation factor 2; Region: IF-2; pfam11987
561007007475	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
561007007476	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
561007007477	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
561007007478	heme-binding site [chemical binding]; other site
561007007479	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
561007007480	FAD binding pocket [chemical binding]; other site
561007007481	FAD binding motif [chemical binding]; other site
561007007482	phosphate binding motif [ion binding]; other site
561007007483	beta-alpha-beta structure motif; other site
561007007484	NAD binding pocket [chemical binding]; other site
561007007485	Rrf2 family protein; Region: rrf2_super; TIGR00738
561007007486	Helix-turn-helix domains; Region: HTH; cl00088
561007007487	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
561007007488	NusA N-terminal domain; Region: NusA_N; pfam08529
561007007489	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
561007007490	RNA binding site [nucleotide binding]; other site
561007007491	homodimer interface [polypeptide binding]; other site
561007007492	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
561007007493	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
561007007494	G-X-X-G motif; other site
561007007495	ribosome maturation protein RimP; Reviewed; Region: PRK00092
561007007496	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
561007007497	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
561007007498	Sm1 motif; other site
561007007499	D1 - D2 interaction site; other site
561007007500	D3 - B interaction site; other site
561007007501	Hfq - Hfq interaction site; other site
561007007502	RNA binding pocket [nucleotide binding]; other site
561007007503	Sm2 motif; other site
561007007504	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
561007007505	dinuclear metal binding motif [ion binding]; other site
561007007506	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
561007007507	putative hydrophobic ligand binding site [chemical binding]; other site
561007007508	protein interface [polypeptide binding]; other site
561007007509	gate; other site
561007007510	prolyl-tRNA synthetase; Provisional; Region: PRK09194
561007007511	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
561007007512	dimer interface [polypeptide binding]; other site
561007007513	motif 1; other site
561007007514	active site
561007007515	motif 2; other site
561007007516	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
561007007517	putative deacylase active site [active]
561007007518	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
561007007519	active site
561007007520	motif 3; other site
561007007521	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
561007007522	anticodon binding site; other site
561007007523	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
561007007524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007007525	putative substrate translocation pore; other site
561007007526	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007527	siroheme synthase; Provisional; Region: cysG; PRK10637
561007007528	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007007529	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
561007007530	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
561007007531	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
561007007532	Walker A/P-loop; other site
561007007533	ATP binding site [chemical binding]; other site
561007007534	Q-loop/lid; other site
561007007535	ABC transporter signature motif; other site
561007007536	Walker B; other site
561007007537	D-loop; other site
561007007538	H-loop/switch region; other site
561007007539	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
561007007540	Walker A/P-loop; other site
561007007541	ATP binding site [chemical binding]; other site
561007007542	Q-loop/lid; other site
561007007543	ABC transporter signature motif; other site
561007007544	Walker B; other site
561007007545	D-loop; other site
561007007546	H-loop/switch region; other site
561007007547	Cobalt transport protein; Region: CbiQ; cl00463
561007007548	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007007549	Condensation domain; Region: Condensation; pfam00668
561007007550	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
561007007551	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007007552	active site
561007007553	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007007554	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
561007007555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007556	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
561007007557	Enoylreductase; Region: PKS_ER; smart00829
561007007558	NAD(P) binding site [chemical binding]; other site
561007007559	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
561007007560	putative NADP binding site [chemical binding]; other site
561007007561	active site
561007007562	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007007563	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007007564	Transport protein; Region: actII; TIGR00833
561007007565	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007566	Helix-turn-helix domains; Region: HTH; cl00088
561007007567	MspA; Region: MspA; pfam09203
561007007568	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
561007007569	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007570	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
561007007571	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
561007007572	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007573	Walker A motif; other site
561007007574	ATP binding site [chemical binding]; other site
561007007575	Walker B motif; other site
561007007576	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
561007007577	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007578	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
561007007579	metal ion-dependent adhesion site (MIDAS); other site
561007007580	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007007581	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007582	Predicted dehydrogenase [General function prediction only]; Region: COG0579
561007007583	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007007584	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
561007007585	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
561007007586	cobyric acid synthase; Provisional; Region: PRK00784
561007007587	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007588	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007589	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
561007007590	catalytic triad [active]
561007007591	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
561007007592	active site
561007007593	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
561007007594	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
561007007595	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
561007007596	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007007597	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
561007007598	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007007599	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007007600	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
561007007601	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
561007007602	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
561007007603	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
561007007604	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
561007007605	active site
561007007606	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
561007007607	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
561007007608	putative substrate binding region [chemical binding]; other site
561007007609	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
561007007610	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
561007007611	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
561007007612	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
561007007613	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
561007007614	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
561007007615	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
561007007616	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
561007007617	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007007618	FeS/SAM binding site; other site
561007007619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007007620	non-specific DNA binding site [nucleotide binding]; other site
561007007621	salt bridge; other site
561007007622	sequence-specific DNA binding site [nucleotide binding]; other site
561007007623	Cupin domain; Region: Cupin_2; cl09118
561007007624	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
561007007625	Methyltransferase domain; Region: Methyltransf_31; pfam13847
561007007626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007007627	S-adenosylmethionine binding site [chemical binding]; other site
561007007628	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007007629	Helix-turn-helix domains; Region: HTH; cl00088
561007007630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007007631	dimerization interface [polypeptide binding]; other site
561007007632	EamA-like transporter family; Region: EamA; cl01037
561007007633	EamA-like transporter family; Region: EamA; cl01037
561007007634	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
561007007635	Dienelactone hydrolase family; Region: DLH; pfam01738
561007007636	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
561007007637	ribosome recycling factor; Reviewed; Region: frr; PRK00083
561007007638	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
561007007639	hinge region; other site
561007007640	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
561007007641	putative nucleotide binding site [chemical binding]; other site
561007007642	uridine monophosphate binding site [chemical binding]; other site
561007007643	homohexameric interface [polypeptide binding]; other site
561007007644	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
561007007645	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007646	Family description; Region: UvrD_C_2; cl15862
561007007647	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
561007007648	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007649	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
561007007650	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007651	Helix-turn-helix domains; Region: HTH; cl00088
561007007652	elongation factor Ts; Provisional; Region: tsf; PRK09377
561007007653	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
561007007654	Elongation factor TS; Region: EF_TS; pfam00889
561007007655	Elongation factor TS; Region: EF_TS; pfam00889
561007007656	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
561007007657	rRNA interaction site [nucleotide binding]; other site
561007007658	S8 interaction site; other site
561007007659	putative laminin-1 binding site; other site
561007007660	Peptidase family M23; Region: Peptidase_M23; pfam01551
561007007661	Helix-turn-helix domains; Region: HTH; cl00088
561007007662	Helix-turn-helix domains; Region: HTH; cl00088
561007007663	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007007664	Transport protein; Region: actII; TIGR00833
561007007665	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
561007007666	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007007667	active site
561007007668	DNA binding site [nucleotide binding]
561007007669	Int/Topo IB signature motif; other site
561007007670	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
561007007671	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
561007007672	FAD binding pocket [chemical binding]; other site
561007007673	FAD binding motif [chemical binding]; other site
561007007674	phosphate binding motif [ion binding]; other site
561007007675	NAD binding pocket [chemical binding]; other site
561007007676	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
561007007677	Helix-turn-helix domains; Region: HTH; cl00088
561007007678	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
561007007679	Helix-turn-helix domains; Region: HTH; cl00088
561007007680	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
561007007681	putative dimerization interface [polypeptide binding]; other site
561007007682	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
561007007683	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
561007007684	active site clefts [active]
561007007685	zinc binding site [ion binding]; other site
561007007686	dimer interface [polypeptide binding]; other site
561007007687	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
561007007688	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
561007007689	Helix-turn-helix domains; Region: HTH; cl00088
561007007690	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
561007007691	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
561007007692	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007693	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
561007007694	Restriction endonuclease; Region: Mrr_cat; cl00516
561007007695	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007696	Helix-turn-helix domains; Region: HTH; cl00088
561007007697	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
561007007698	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
561007007699	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
561007007700	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
561007007701	RNA/DNA hybrid binding site [nucleotide binding]; other site
561007007702	active site
561007007703	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
561007007704	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
561007007705	Catalytic site [active]
561007007706	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
561007007707	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
561007007708	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007007709	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
561007007710	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
561007007711	RimM N-terminal domain; Region: RimM; pfam01782
561007007712	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
561007007713	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
561007007714	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
561007007715	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007007716	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007007717	CoenzymeA binding site [chemical binding]; other site
561007007718	subunit interaction site [polypeptide binding]; other site
561007007719	PHB binding site; other site
561007007720	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
561007007721	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007007722	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
561007007723	Zn binding site [ion binding]; other site
561007007724	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
561007007725	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007007726	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
561007007727	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007007728	active site
561007007729	signal recognition particle protein; Provisional; Region: PRK10867
561007007730	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
561007007731	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
561007007732	P loop; other site
561007007733	GTP binding site [chemical binding]; other site
561007007734	Signal peptide binding domain; Region: SRP_SPB; pfam02978
561007007735	PII uridylyl-transferase; Provisional; Region: PRK03381
561007007736	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
561007007737	metal binding triad; other site
561007007738	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
561007007739	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007007740	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
561007007741	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
561007007742	Nitrogen regulatory protein P-II; Region: P-II; cl00412
561007007743	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
561007007744	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
561007007745	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
561007007746	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007747	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
561007007748	isopentenyl-diphosphate delta-isomerase, type 2; Region: IPP_isom_2; TIGR02151
561007007749	homotetramer interface [polypeptide binding]; other site
561007007750	FMN binding site [chemical binding]; other site
561007007751	homodimer contacts [polypeptide binding]; other site
561007007752	putative active site [active]
561007007753	putative substrate binding site [chemical binding]; other site
561007007754	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
561007007755	catalytic residues [active]
561007007756	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007007757	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
561007007758	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007007759	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
561007007760	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
561007007761	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007007762	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
561007007763	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
561007007764	ABC transporter signature motif; other site
561007007765	Walker B; other site
561007007766	D-loop; other site
561007007767	H-loop/switch region; other site
561007007768	OsmC-like protein; Region: OsmC; cl00767
561007007769	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
561007007770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007007771	active site
561007007772	phosphorylation site [posttranslational modification]
561007007773	intermolecular recognition site; other site
561007007774	dimerization interface [polypeptide binding]; other site
561007007775	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007007776	DNA binding site [nucleotide binding]
561007007777	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
561007007778	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
561007007779	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
561007007780	Ligand Binding Site [chemical binding]; other site
561007007781	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
561007007782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007007783	phosphorylation site [posttranslational modification]
561007007784	dimer interface [polypeptide binding]; other site
561007007785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007007786	ATP binding site [chemical binding]; other site
561007007787	Mg2+ binding site [ion binding]; other site
561007007788	G-X-G motif; other site
561007007789	K+-transporting ATPase, c chain; Region: KdpC; cl00944
561007007790	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
561007007791	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
561007007792	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007007793	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
561007007794	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
561007007795	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
561007007796	DNA binding site [nucleotide binding]
561007007797	catalytic residue [active]
561007007798	H2TH interface [polypeptide binding]; other site
561007007799	putative catalytic residues [active]
561007007800	turnover-facilitating residue; other site
561007007801	intercalation triad [nucleotide binding]; other site
561007007802	8OG recognition residue [nucleotide binding]; other site
561007007803	putative reading head residues; other site
561007007804	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
561007007805	ribonuclease III; Reviewed; Region: rnc; PRK00102
561007007806	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
561007007807	dimerization interface [polypeptide binding]; other site
561007007808	active site
561007007809	metal binding site [ion binding]; metal-binding site
561007007810	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
561007007811	dsRNA binding site [nucleotide binding]; other site
561007007812	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
561007007813	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
561007007814	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
561007007815	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
561007007816	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
561007007817	active site
561007007818	(T/H)XGH motif; other site
561007007819	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
561007007820	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
561007007821	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
561007007822	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007007823	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
561007007824	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007007825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007007826	S-adenosylmethionine binding site [chemical binding]; other site
561007007827	pyruvate carboxylase; Reviewed; Region: PRK12999
561007007828	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
561007007829	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
561007007830	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
561007007831	active site
561007007832	catalytic residues [active]
561007007833	metal binding site [ion binding]; metal-binding site
561007007834	homodimer binding site [polypeptide binding]; other site
561007007835	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
561007007836	carboxyltransferase (CT) interaction site; other site
561007007837	biotinylation site [posttranslational modification]; other site
561007007838	Vitamin K epoxide reductase family; Region: VKOR; cl01729
561007007839	pectinesterase; Region: PLN02314
561007007840	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007007841	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007007842	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007007843	substrate binding pocket [chemical binding]; other site
561007007844	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007007845	Cutinase; Region: Cutinase; pfam01083
561007007846	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007847	Helix-turn-helix domains; Region: HTH; cl00088
561007007848	Cytochrome P450; Region: p450; pfam00067
561007007849	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007007850	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
561007007851	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
561007007852	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
561007007853	generic binding surface II; other site
561007007854	ssDNA binding site; other site
561007007855	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007007856	ATP binding site [chemical binding]; other site
561007007857	putative Mg++ binding site [ion binding]; other site
561007007858	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007007859	nucleotide binding region [chemical binding]; other site
561007007860	ATP-binding site [chemical binding]; other site
561007007861	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
561007007862	DAK2 domain; Region: Dak2; cl03685
561007007863	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
561007007864	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
561007007865	enoyl-CoA hydratase; Provisional; Region: PRK06688
561007007866	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007007867	substrate binding site [chemical binding]; other site
561007007868	oxyanion hole (OAH) forming residues; other site
561007007869	trimer interface [polypeptide binding]; other site
561007007870	Secretory lipase; Region: LIP; pfam03583
561007007871	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
561007007872	ligand binding site [chemical binding]; other site
561007007873	active site
561007007874	UGI interface [polypeptide binding]; other site
561007007875	catalytic site [active]
561007007876	thiamine monophosphate kinase; Provisional; Region: PRK05731
561007007877	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
561007007878	ATP binding site [chemical binding]; other site
561007007879	dimerization interface [polypeptide binding]; other site
561007007880	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
561007007881	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
561007007882	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
561007007883	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007007884	cystathionine gamma-lyase; Validated; Region: PRK07582
561007007885	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007007886	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007007887	catalytic residue [active]
561007007888	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
561007007889	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007890	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
561007007891	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
561007007892	polyphosphate kinase; Provisional; Region: PRK05443
561007007893	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
561007007894	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
561007007895	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
561007007896	putative domain interface [polypeptide binding]; other site
561007007897	putative active site [active]
561007007898	catalytic site [active]
561007007899	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
561007007900	putative domain interface [polypeptide binding]; other site
561007007901	putative active site [active]
561007007902	catalytic site [active]
561007007903	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
561007007904	active site
561007007905	Ap6A binding site [chemical binding]; other site
561007007906	nudix motif; other site
561007007907	metal binding site [ion binding]; metal-binding site
561007007908	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007007909	catalytic core [active]
561007007910	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
561007007911	IHF - DNA interface [nucleotide binding]; other site
561007007912	IHF dimer interface [polypeptide binding]; other site
561007007913	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
561007007914	substrate binding site [chemical binding]; other site
561007007915	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
561007007916	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
561007007917	substrate binding site [chemical binding]; other site
561007007918	ligand binding site [chemical binding]; other site
561007007919	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007007920	Helix-turn-helix domains; Region: HTH; cl00088
561007007921	Bacterial transcriptional regulator; Region: IclR; pfam01614
561007007922	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
561007007923	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007007924	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
561007007925	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
561007007926	HIGH motif; other site
561007007927	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
561007007928	active site
561007007929	KMSKS motif; other site
561007007930	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
561007007931	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007007932	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007007933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007007934	putative substrate translocation pore; other site
561007007935	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
561007007936	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
561007007937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007938	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
561007007939	putative L-serine binding site [chemical binding]; other site
561007007940	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007007941	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
561007007942	putative NAD(P) binding site [chemical binding]; other site
561007007943	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007007944	Helix-turn-helix domains; Region: HTH; cl00088
561007007945	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
561007007946	putative dimerization interface [polypeptide binding]; other site
561007007947	Protein of unknown function, DUF417; Region: DUF417; cl01162
561007007948	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
561007007949	dimer interface [polypeptide binding]; other site
561007007950	FMN binding site [chemical binding]; other site
561007007951	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007007952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007953	Helix-turn-helix domains; Region: HTH; cl00088
561007007954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007007955	Helix-turn-helix domains; Region: HTH; cl00088
561007007956	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007007957	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007007958	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007007959	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
561007007960	AMP-binding enzyme; Region: AMP-binding; cl15778
561007007961	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007007962	Condensation domain; Region: Condensation; pfam00668
561007007963	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007007964	peptide synthase; Provisional; Region: PRK12467
561007007965	AMP-binding enzyme; Region: AMP-binding; cl15778
561007007966	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007007967	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
561007007968	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
561007007969	putative NAD(P) binding site [chemical binding]; other site
561007007970	active site
561007007971	putative substrate binding site [chemical binding]; other site
561007007972	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007007973	dimerization interface [polypeptide binding]; other site
561007007974	putative DNA binding site [nucleotide binding]; other site
561007007975	putative Zn2+ binding site [ion binding]; other site
561007007976	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007007977	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
561007007978	ketol-acid reductoisomerase; Provisional; Region: PRK05479
561007007979	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007007980	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
561007007981	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
561007007982	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
561007007983	putative valine binding site [chemical binding]; other site
561007007984	dimer interface [polypeptide binding]; other site
561007007985	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
561007007986	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
561007007987	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
561007007988	PYR/PP interface [polypeptide binding]; other site
561007007989	dimer interface [polypeptide binding]; other site
561007007990	TPP binding site [chemical binding]; other site
561007007991	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
561007007992	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
561007007993	TPP-binding site [chemical binding]; other site
561007007994	dimer interface [polypeptide binding]; other site
561007007995	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
561007007996	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
561007007997	hypothetical protein; Provisional; Region: PRK06541
561007007998	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007007999	inhibitor-cofactor binding pocket; inhibition site
561007008000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007008001	catalytic residue [active]
561007008002	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
561007008003	Helix-turn-helix domains; Region: HTH; cl00088
561007008004	AsnC family; Region: AsnC_trans_reg; pfam01037
561007008005	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007008006	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
561007008007	NAD(P) binding site [chemical binding]; other site
561007008008	catalytic residues [active]
561007008009	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
561007008010	Helix-turn-helix domains; Region: HTH; cl00088
561007008011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008012	FAD binding domain; Region: FAD_binding_3; pfam01494
561007008013	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
561007008014	Spore germination protein; Region: Spore_permease; cl15802
561007008015	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
561007008016	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
561007008017	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
561007008018	GatB domain; Region: GatB_Yqey; cl11497
561007008019	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
561007008020	active site
561007008021	ADP/pyrophosphate binding site [chemical binding]; other site
561007008022	dimerization interface [polypeptide binding]; other site
561007008023	allosteric effector site; other site
561007008024	fructose-1,6-bisphosphate binding site; other site
561007008025	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007008026	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
561007008027	substrate binding pocket [chemical binding]; other site
561007008028	catalytic triad [active]
561007008029	Protein of unknown function, DUF417; Region: DUF417; cl01162
561007008030	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007008031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007008032	active site
561007008033	phosphorylation site [posttranslational modification]
561007008034	intermolecular recognition site; other site
561007008035	dimerization interface [polypeptide binding]; other site
561007008036	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007008037	DNA binding site [nucleotide binding]
561007008038	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
561007008039	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007008040	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
561007008041	dimer interface [polypeptide binding]; other site
561007008042	phosphorylation site [posttranslational modification]
561007008043	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007008044	ATP binding site [chemical binding]; other site
561007008045	Mg2+ binding site [ion binding]; other site
561007008046	G-X-G motif; other site
561007008047	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
561007008048	Amidase; Region: Amidase; cl11426
561007008049	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
561007008050	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
561007008051	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
561007008052	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
561007008053	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
561007008054	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
561007008055	nucleotide binding pocket [chemical binding]; other site
561007008056	K-X-D-G motif; other site
561007008057	catalytic site [active]
561007008058	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
561007008059	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
561007008060	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
561007008061	Dimer interface [polypeptide binding]; other site
561007008062	BRCT sequence motif; other site
561007008063	Protein of unknown function (DUF419); Region: DUF419; cl15265
561007008064	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
561007008065	enoyl-CoA hydratase; Provisional; Region: PRK06142
561007008066	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007008067	substrate binding site [chemical binding]; other site
561007008068	oxyanion hole (OAH) forming residues; other site
561007008069	trimer interface [polypeptide binding]; other site
561007008070	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
561007008071	putative FMN binding site [chemical binding]; other site
561007008072	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
561007008073	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
561007008074	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
561007008075	homodimer interface [polypeptide binding]; other site
561007008076	putative substrate binding pocket [chemical binding]; other site
561007008077	diiron center [ion binding]; other site
561007008078	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
561007008079	active site
561007008080	catalytic triad [active]
561007008081	oxyanion hole [active]
561007008082	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
561007008083	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
561007008084	Ligand Binding Site [chemical binding]; other site
561007008085	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007008086	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
561007008087	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007008088	catalytic residue [active]
561007008089	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
561007008090	putative acyl-acceptor binding pocket; other site
561007008091	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007008092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008093	NADH(P)-binding; Region: NAD_binding_10; pfam13460
561007008094	NAD(P) binding site [chemical binding]; other site
561007008095	active site
561007008096	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007008097	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
561007008098	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007008099	DNA binding residues [nucleotide binding]
561007008100	dimerization interface [polypeptide binding]; other site
561007008101	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
561007008102	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
561007008103	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
561007008104	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
561007008105	Ligand binding site [chemical binding]; other site
561007008106	Electron transfer flavoprotein domain; Region: ETF; pfam01012
561007008107	Methyltransferase domain; Region: Methyltransf_31; pfam13847
561007008108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007008109	S-adenosylmethionine binding site [chemical binding]; other site
561007008110	Uncharacterized conserved protein [Function unknown]; Region: COG1543
561007008111	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
561007008112	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
561007008113	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
561007008114	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
561007008115	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
561007008116	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008117	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007008118	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
561007008119	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
561007008120	putative NAD(P) binding site [chemical binding]; other site
561007008121	active site
561007008122	putative substrate binding site [chemical binding]; other site
561007008123	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
561007008124	Helix-turn-helix domains; Region: HTH; cl00088
561007008125	AsnC family; Region: AsnC_trans_reg; pfam01037
561007008126	AzlC protein; Region: AzlC; cl00570
561007008127	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
561007008128	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008129	Helix-turn-helix domains; Region: HTH; cl00088
561007008130	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007008131	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007008132	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007008133	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007008134	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007008135	dimerization interface [polypeptide binding]; other site
561007008136	putative DNA binding site [nucleotide binding]; other site
561007008137	putative Zn2+ binding site [ion binding]; other site
561007008138	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
561007008139	putative hydrophobic ligand binding site [chemical binding]; other site
561007008140	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007008141	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
561007008142	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
561007008143	trimer interface [polypeptide binding]; other site
561007008144	active site
561007008145	substrate binding site [chemical binding]; other site
561007008146	CoA binding site [chemical binding]; other site
561007008147	FOG: WD40-like repeat [Function unknown]; Region: COG1520
561007008148	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
561007008149	Trp docking motif [polypeptide binding]; other site
561007008150	active site
561007008151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007008152	S-adenosylmethionine binding site [chemical binding]; other site
561007008153	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007008154	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
561007008155	substrate binding site [chemical binding]; other site
561007008156	oxyanion hole (OAH) forming residues; other site
561007008157	trimer interface [polypeptide binding]; other site
561007008158	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
561007008159	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
561007008160	Walker A/P-loop; other site
561007008161	ATP binding site [chemical binding]; other site
561007008162	Q-loop/lid; other site
561007008163	ABC transporter signature motif; other site
561007008164	Walker B; other site
561007008165	D-loop; other site
561007008166	H-loop/switch region; other site
561007008167	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
561007008168	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
561007008169	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
561007008170	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
561007008171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007008172	DNA-binding site [nucleotide binding]; DNA binding site
561007008173	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007008174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007008175	homodimer interface [polypeptide binding]; other site
561007008176	catalytic residue [active]
561007008177	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
561007008178	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
561007008179	phosphoserine phosphatase SerB; Region: serB; TIGR00338
561007008180	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
561007008181	motif II; other site
561007008182	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
561007008183	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
561007008184	D-pathway; other site
561007008185	Putative ubiquinol binding site [chemical binding]; other site
561007008186	Low-spin heme (heme b) binding site [chemical binding]; other site
561007008187	Putative water exit pathway; other site
561007008188	Binuclear center (heme o3/CuB) [ion binding]; other site
561007008189	K-pathway; other site
561007008190	Putative proton exit pathway; other site
561007008191	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
561007008192	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
561007008193	siderophore binding site; other site
561007008194	YCII-related domain; Region: YCII; cl00999
561007008195	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007008196	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007008197	hydrophobic ligand binding site; other site
561007008198	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
561007008199	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
561007008200	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
561007008201	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007008202	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
561007008203	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
561007008204	Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome.  The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223
561007008205	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
561007008206	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
561007008207	putative NAD(P) binding site [chemical binding]; other site
561007008208	putative substrate binding site [chemical binding]; other site
561007008209	catalytic Zn binding site [ion binding]; other site
561007008210	structural Zn binding site [ion binding]; other site
561007008211	dimer interface [polypeptide binding]; other site
561007008212	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
561007008213	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
561007008214	active site
561007008215	non-prolyl cis peptide bond; other site
561007008216	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
561007008217	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
561007008218	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
561007008219	dimer interface [polypeptide binding]; other site
561007008220	putative radical transfer pathway; other site
561007008221	diiron center [ion binding]; other site
561007008222	tyrosyl radical; other site
561007008223	short chain dehydrogenase; Provisional; Region: PRK07825
561007008224	classical (c) SDRs; Region: SDR_c; cd05233
561007008225	NAD(P) binding site [chemical binding]; other site
561007008226	active site
561007008227	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
561007008228	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
561007008229	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
561007008230	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007008231	SCP-2 sterol transfer family; Region: SCP2; cl01225
561007008232	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
561007008233	dimerization interface [polypeptide binding]; other site
561007008234	substrate binding pocket [chemical binding]; other site
561007008235	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047
561007008236	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
561007008237	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
561007008238	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
561007008239	Class I ribonucleotide reductase; Region: RNR_I; cd01679
561007008240	active site
561007008241	dimer interface [polypeptide binding]; other site
561007008242	catalytic residues [active]
561007008243	effector binding site; other site
561007008244	R2 peptide binding site; other site
561007008245	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007008246	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
561007008247	catalytic residues [active]
561007008248	metabolite-proton symporter; Region: 2A0106; TIGR00883
561007008249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007008250	putative substrate translocation pore; other site
561007008251	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007008252	Helix-turn-helix domains; Region: HTH; cl00088
561007008253	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
561007008254	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
561007008255	homodimer interface [polypeptide binding]; other site
561007008256	NAD binding pocket [chemical binding]; other site
561007008257	ATP binding pocket [chemical binding]; other site
561007008258	Mg binding site [ion binding]; other site
561007008259	active-site loop [active]
561007008260	short chain dehydrogenase; Provisional; Region: PRK07832
561007008261	classical (c) SDRs; Region: SDR_c; cd05233
561007008262	NAD(P) binding site [chemical binding]; other site
561007008263	active site
561007008264	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
561007008265	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
561007008266	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008267	Helix-turn-helix domains; Region: HTH; cl00088
561007008268	Cytochrome P450; Region: p450; pfam00067
561007008269	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007008270	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
561007008271	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
561007008272	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007008273	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
561007008274	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
561007008275	short chain dehydrogenase; Provisional; Region: PRK12744
561007008276	NADP binding site [chemical binding]; other site
561007008277	homodimer interface [polypeptide binding]; other site
561007008278	active site
561007008279	substrate binding site [chemical binding]; other site
561007008280	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008281	NAD(P) binding site [chemical binding]; other site
561007008282	active site
561007008283	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
561007008284	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007008285	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007008286	DNA binding residues [nucleotide binding]
561007008287	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
561007008288	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
561007008289	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
561007008290	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
561007008291	Putative zinc-finger; Region: zf-HC2; cl15806
561007008292	Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039
561007008293	Isochorismatase family; Region: Isochorismatase; pfam00857
561007008294	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
561007008295	catalytic triad [active]
561007008296	conserved cis-peptide bond; other site
561007008297	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
561007008298	Na binding site [ion binding]; other site
561007008299	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
561007008300	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
561007008301	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008302	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008303	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
561007008304	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008305	Helix-turn-helix domains; Region: HTH; cl00088
561007008306	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
561007008307	short chain dehydrogenase; Provisional; Region: PRK06197
561007008308	putative NAD(P) binding site [chemical binding]; other site
561007008309	active site
561007008310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008311	NAD(P) binding site [chemical binding]; other site
561007008312	active site
561007008313	NAD-dependent deacetylase; Provisional; Region: PRK00481
561007008314	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
561007008315	NAD+ binding site [chemical binding]; other site
561007008316	substrate binding site [chemical binding]; other site
561007008317	Zn binding site [ion binding]; other site
561007008318	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
561007008319	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
561007008320	Transcription factor WhiB; Region: Whib; pfam02467
561007008321	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
561007008322	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007008323	OpgC protein; Region: OpgC_C; cl00792
561007008324	Acyltransferase family; Region: Acyl_transf_3; pfam01757
561007008325	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
561007008326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007008327	putative substrate translocation pore; other site
561007008328	phosphoglucomutase; Validated; Region: PRK07564
561007008329	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
561007008330	active site
561007008331	substrate binding site [chemical binding]; other site
561007008332	metal binding site [ion binding]; metal-binding site
561007008333	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
561007008334	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
561007008335	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007008336	substrate binding pocket [chemical binding]; other site
561007008337	catalytic triad [active]
561007008338	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
561007008339	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007008340	substrate binding pocket [chemical binding]; other site
561007008341	catalytic triad [active]
561007008342	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
561007008343	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
561007008344	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007008345	dimer interface [polypeptide binding]; other site
561007008346	active site
561007008347	Helix-turn-helix domains; Region: HTH; cl00088
561007008348	Domain of unknown function (DUF1990); Region: DUF1990; cl01969
561007008349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007008350	Helix-turn-helix domains; Region: HTH; cl00088
561007008351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007008352	dimerization interface [polypeptide binding]; other site
561007008353	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
561007008354	nucleoside/Zn binding site; other site
561007008355	dimer interface [polypeptide binding]; other site
561007008356	catalytic motif [active]
561007008357	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
561007008358	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
561007008359	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007008360	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008361	Helix-turn-helix domains; Region: HTH; cl00088
561007008362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007008363	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
561007008364	anti sigma factor interaction site; other site
561007008365	regulatory phosphorylation site [posttranslational modification]; other site
561007008366	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
561007008367	putative dimer interface [polypeptide binding]; other site
561007008368	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
561007008369	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
561007008370	DNA binding residues [nucleotide binding]
561007008371	putative dimer interface [polypeptide binding]; other site
561007008372	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
561007008373	nudix motif; other site
561007008374	acetolactate synthase; Reviewed; Region: PRK08322
561007008375	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
561007008376	dimer interface [polypeptide binding]; other site
561007008377	PYR/PP interface [polypeptide binding]; other site
561007008378	TPP binding site [chemical binding]; other site
561007008379	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
561007008380	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
561007008381	TPP-binding site [chemical binding]; other site
561007008382	dimer interface [polypeptide binding]; other site
561007008383	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007008384	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
561007008385	NAD(P) binding site [chemical binding]; other site
561007008386	catalytic residues [active]
561007008387	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
561007008388	SmpB-tmRNA interface; other site
561007008389	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
561007008390	FtsX-like permease family; Region: FtsX; cl15850
561007008391	FtsX-like permease family; Region: FtsX; cl15850
561007008392	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
561007008393	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007008394	Walker A/P-loop; other site
561007008395	ATP binding site [chemical binding]; other site
561007008396	Q-loop/lid; other site
561007008397	ABC transporter signature motif; other site
561007008398	Walker B; other site
561007008399	D-loop; other site
561007008400	H-loop/switch region; other site
561007008401	Mechanosensitive ion channel; Region: MS_channel; pfam00924
561007008402	peptide chain release factor 2; Validated; Region: prfB; PRK00578
561007008403	RF-1 domain; Region: RF-1; cl02875
561007008404	RF-1 domain; Region: RF-1; cl02875
561007008405	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007008406	Helix-turn-helix domains; Region: HTH; cl00088
561007008407	Bacterial transcriptional regulator; Region: IclR; pfam01614
561007008408	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008409	active site
561007008410	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007008411	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007008412	active site
561007008413	ferredoxin-NADP+ reductase; Region: PLN02852
561007008414	hypothetical protein; Provisional; Region: PRK06834
561007008415	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008417	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
561007008418	active site
561007008419	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007008420	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007008421	active site
561007008422	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007008423	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007008424	active site
561007008425	acyl-CoA synthetase; Validated; Region: PRK07788
561007008426	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008427	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007008428	Clp protease ATP binding subunit; Region: clpC; CHL00095
561007008429	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007008430	Cupin domain; Region: Cupin_2; cl09118
561007008431	Protein of unknown function (DUF4241); Region: DUF4241; pfam14025
561007008432	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
561007008433	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
561007008434	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
561007008435	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
561007008436	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
561007008437	Protein of unknown function, DUF393; Region: DUF393; cl01136
561007008438	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
561007008439	MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816
561007008440	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
561007008441	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007008442	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007008443	active site
561007008444	ATP binding site [chemical binding]; other site
561007008445	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
561007008446	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007008447	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007008448	active site
561007008449	ATP binding site [chemical binding]; other site
561007008450	Domain of unknown function (DUF336); Region: DUF336; cl01249
561007008451	short chain dehydrogenase; Provisional; Region: PRK09291
561007008452	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
561007008453	NADP binding site [chemical binding]; other site
561007008454	active site
561007008455	steroid binding site; other site
561007008456	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
561007008457	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007008458	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
561007008459	active site
561007008460	ATP binding site [chemical binding]; other site
561007008461	Transcription factor WhiB; Region: Whib; pfam02467
561007008462	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
561007008463	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
561007008464	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007008465	Family description; Region: UvrD_C_2; cl15862
561007008466	HRDC domain; Region: HRDC; cl02578
561007008467	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
561007008468	catalytic residues [active]
561007008469	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
561007008470	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
561007008471	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
561007008472	putative NADH binding site [chemical binding]; other site
561007008473	putative active site [active]
561007008474	nudix motif; other site
561007008475	putative metal binding site [ion binding]; other site
561007008476	Ion channel; Region: Ion_trans_2; cl11596
561007008477	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
561007008478	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008479	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
561007008480	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
561007008481	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
561007008482	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
561007008483	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
561007008484	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007008485	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007008486	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007008487	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
561007008488	active site
561007008489	DNA binding site [nucleotide binding]
561007008490	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
561007008491	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
561007008492	putative active site [active]
561007008493	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
561007008494	putative active site [active]
561007008495	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
561007008496	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
561007008497	active site
561007008498	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007008499	DNA binding site [nucleotide binding]
561007008500	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
561007008501	nitrite reductase subunit NirD; Provisional; Region: PRK14989
561007008502	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
561007008503	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
561007008504	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
561007008505	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
561007008506	TIGR02569 family protein; Region: TIGR02569_actnb
561007008507	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
561007008508	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
561007008509	ATP binding site [chemical binding]; other site
561007008510	substrate interface [chemical binding]; other site
561007008511	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
561007008512	active site residue [active]
561007008513	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
561007008514	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008515	Helix-turn-helix domains; Region: HTH; cl00088
561007008516	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
561007008517	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007008518	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
561007008519	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
561007008520	DEAD-like helicases superfamily; Region: DEXDc; smart00487
561007008521	ATP binding site [chemical binding]; other site
561007008522	Mg++ binding site [ion binding]; other site
561007008523	motif III; other site
561007008524	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007008525	nucleotide binding region [chemical binding]; other site
561007008526	ATP-binding site [chemical binding]; other site
561007008527	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
561007008528	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
561007008529	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007008530	P-loop; other site
561007008531	Magnesium ion binding site [ion binding]; other site
561007008532	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007008533	Magnesium ion binding site [ion binding]; other site
561007008534	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007008535	catalytic core [active]
561007008536	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
561007008537	chorismate binding enzyme; Region: Chorismate_bind; cl10555
561007008538	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007008539	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007008540	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
561007008541	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
561007008542	Transcription factor WhiB; Region: Whib; pfam02467
561007008543	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
561007008544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
561007008545	Histidine kinase; Region: HisKA_2; cl06527
561007008546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007008547	ATP binding site [chemical binding]; other site
561007008548	Mg2+ binding site [ion binding]; other site
561007008549	G-X-G motif; other site
561007008550	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
561007008551	carboxyltransferase (CT) interaction site; other site
561007008552	biotinylation site [posttranslational modification]; other site
561007008553	Putative zinc-finger; Region: zf-HC2; cl15806
561007008554	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
561007008555	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007008556	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007008557	DNA binding residues [nucleotide binding]
561007008558	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
561007008559	putative deacylase active site [active]
561007008560	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
561007008561	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
561007008562	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
561007008563	hinge; other site
561007008564	active site
561007008565	Predicted GTPases [General function prediction only]; Region: COG1162
561007008566	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
561007008567	GTPase/Zn-binding domain interface [polypeptide binding]; other site
561007008568	GTP/Mg2+ binding site [chemical binding]; other site
561007008569	G4 box; other site
561007008570	G5 box; other site
561007008571	G1 box; other site
561007008572	Switch I region; other site
561007008573	G2 box; other site
561007008574	G3 box; other site
561007008575	Switch II region; other site
561007008576	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
561007008577	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
561007008578	putative di-iron ligands [ion binding]; other site
561007008579	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
561007008580	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
561007008581	FAD binding pocket [chemical binding]; other site
561007008582	FAD binding motif [chemical binding]; other site
561007008583	phosphate binding motif [ion binding]; other site
561007008584	beta-alpha-beta structure motif; other site
561007008585	NAD binding pocket [chemical binding]; other site
561007008586	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007008587	catalytic loop [active]
561007008588	iron binding site [ion binding]; other site
561007008589	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
561007008590	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
561007008591	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
561007008592	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
561007008593	active site
561007008594	catalytic residues [active]
561007008595	metal binding site [ion binding]; metal-binding site
561007008596	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
561007008597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008598	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
561007008599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007008600	putative substrate translocation pore; other site
561007008601	Epoxide hydrolase N terminus; Region: EHN; pfam06441
561007008602	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007008603	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
561007008604	Transport protein; Region: actII; TIGR00833
561007008605	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007008606	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007008607	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008608	Helix-turn-helix domains; Region: HTH; cl00088
561007008609	Putative cyclase; Region: Cyclase; cl00814
561007008610	Putative cyclase; Region: Cyclase; cl00814
561007008611	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007008612	Uncharacterized conserved protein [Function unknown]; Region: COG2128
561007008613	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
561007008614	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007008615	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
561007008616	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
561007008617	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
561007008618	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007008619	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
561007008620	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007008621	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
561007008622	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
561007008623	active site
561007008624	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
561007008625	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
561007008626	active site
561007008627	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
561007008628	Acyl transferase domain; Region: Acyl_transf_1; cl08282
561007008629	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007008630	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007008631	active site
561007008632	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007008633	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007008634	active site
561007008635	acyl-CoA synthetase; Validated; Region: PRK05850
561007008636	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008637	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
561007008638	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
561007008639	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007008640	CoenzymeA binding site [chemical binding]; other site
561007008641	subunit interaction site [polypeptide binding]; other site
561007008642	PHB binding site; other site
561007008643	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
561007008644	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007008645	DNA-binding site [nucleotide binding]; DNA binding site
561007008646	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007008647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007008648	homodimer interface [polypeptide binding]; other site
561007008649	catalytic residue [active]
561007008650	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250
561007008651	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
561007008652	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008653	Helix-turn-helix domains; Region: HTH; cl00088
561007008654	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007008655	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007008656	active site
561007008657	lipoprotein LpqB; Provisional; Region: PRK13616
561007008658	Sporulation and spore germination; Region: Germane; cl11253
561007008659	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
561007008660	dimerization interface [polypeptide binding]; other site
561007008661	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007008662	dimer interface [polypeptide binding]; other site
561007008663	phosphorylation site [posttranslational modification]
561007008664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007008665	ATP binding site [chemical binding]; other site
561007008666	Mg2+ binding site [ion binding]; other site
561007008667	G-X-G motif; other site
561007008668	Ycf27; Reviewed; Region: orf27; CHL00148
561007008669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007008670	active site
561007008671	phosphorylation site [posttranslational modification]
561007008672	intermolecular recognition site; other site
561007008673	dimerization interface [polypeptide binding]; other site
561007008674	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007008675	DNA binding site [nucleotide binding]
561007008676	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
561007008677	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008678	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007008679	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
561007008680	MgtC family; Region: MgtC; pfam02308
561007008681	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
561007008682	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
561007008683	TMP-binding site; other site
561007008684	ATP-binding site [chemical binding]; other site
561007008685	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
561007008686	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
561007008687	oligomerization interface [polypeptide binding]; other site
561007008688	active site
561007008689	NAD+ binding site [chemical binding]; other site
561007008690	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008691	Helix-turn-helix domains; Region: HTH; cl00088
561007008692	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
561007008693	Rubredoxin; Region: Rubredoxin; pfam00301
561007008694	iron binding site [ion binding]; other site
561007008695	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
561007008696	Fatty acid desaturase; Region: FA_desaturase; pfam00487
561007008697	Di-iron ligands [ion binding]; other site
561007008698	amino acid transporter; Region: 2A0306; TIGR00909
561007008699	Spore germination protein; Region: Spore_permease; cl15802
561007008700	Spore germination protein; Region: Spore_permease; cl15802
561007008701	Cation efflux family; Region: Cation_efflux; cl00316
561007008702	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
561007008703	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
561007008704	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
561007008705	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
561007008706	active site
561007008707	substrate binding site [chemical binding]; other site
561007008708	metal binding site [ion binding]; metal-binding site
561007008709	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
561007008710	Transcription factor WhiB; Region: Whib; pfam02467
561007008711	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
561007008712	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
561007008713	dimer interface [polypeptide binding]; other site
561007008714	substrate binding site [chemical binding]; other site
561007008715	phosphate binding site [ion binding]; other site
561007008716	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
561007008717	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
561007008718	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
561007008719	putative FMN binding site [chemical binding]; other site
561007008720	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
561007008721	nudix motif; other site
561007008722	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
561007008723	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
561007008724	active site
561007008725	Substrate binding site; other site
561007008726	Mg++ binding site; other site
561007008727	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
561007008728	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
561007008729	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
561007008730	Probable Catalytic site; other site
561007008731	metal-binding site
561007008732	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
561007008733	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
561007008734	NADP binding site [chemical binding]; other site
561007008735	active site
561007008736	putative substrate binding site [chemical binding]; other site
561007008737	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
561007008738	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
561007008739	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008740	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
561007008741	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
561007008742	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007008743	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
561007008744	FAD binding site [chemical binding]; other site
561007008745	homotetramer interface [polypeptide binding]; other site
561007008746	substrate binding pocket [chemical binding]; other site
561007008747	catalytic base [active]
561007008748	AIR carboxylase; Region: AIRC; cl00310
561007008749	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
561007008750	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007008751	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
561007008752	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
561007008753	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
561007008754	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
561007008755	NADP binding site [chemical binding]; other site
561007008756	dimer interface [polypeptide binding]; other site
561007008757	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
561007008758	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007008759	Bacterial PH domain; Region: DUF304; cl01348
561007008760	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
561007008761	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
561007008762	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
561007008763	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
561007008764	acyl-CoA synthetase; Provisional; Region: PRK13388
561007008765	AMP-binding enzyme; Region: AMP-binding; cl15778
561007008766	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007008767	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
561007008768	Helix-turn-helix domains; Region: HTH; cl00088
561007008769	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
561007008770	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007008771	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007008772	Maf-like protein; Region: Maf; pfam02545
561007008773	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
561007008774	active site
561007008775	dimer interface [polypeptide binding]; other site
561007008776	GntP family permease; Region: GntP_permease; pfam02447
561007008777	Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264
561007008778	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
561007008779	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007008780	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007008781	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007008782	active site
561007008783	Phosphotransferase enzyme family; Region: APH; pfam01636
561007008784	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
561007008785	putative active site [active]
561007008786	ATP binding site [chemical binding]; other site
561007008787	putative substrate binding site [chemical binding]; other site
561007008788	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007008789	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
561007008790	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
561007008791	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
561007008792	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
561007008793	active site residue [active]
561007008794	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
561007008795	active site residue [active]
561007008796	Fe-S metabolism associated domain; Region: SufE; cl00951
561007008797	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
561007008798	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
561007008799	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007008800	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
561007008801	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
561007008802	carboxyltransferase (CT) interaction site; other site
561007008803	biotinylation site [posttranslational modification]; other site
561007008804	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
561007008805	L-lysine aminotransferase; Provisional; Region: PRK08297
561007008806	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007008807	inhibitor-cofactor binding pocket; inhibition site
561007008808	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007008809	catalytic residue [active]
561007008810	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
561007008811	Helix-turn-helix domains; Region: HTH; cl00088
561007008812	AsnC family; Region: AsnC_trans_reg; pfam01037
561007008813	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
561007008814	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
561007008815	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007008816	tetrameric interface [polypeptide binding]; other site
561007008817	NAD binding site [chemical binding]; other site
561007008818	catalytic residues [active]
561007008819	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007008820	Helix-turn-helix domains; Region: HTH; cl00088
561007008821	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007008822	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
561007008823	ATP binding site [chemical binding]; other site
561007008824	putative Mg++ binding site [ion binding]; other site
561007008825	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
561007008826	nucleotide binding region [chemical binding]; other site
561007008827	ATP-binding site [chemical binding]; other site
561007008828	DEAD/H associated; Region: DEAD_assoc; pfam08494
561007008829	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
561007008830	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
561007008831	dimer interface [polypeptide binding]; other site
561007008832	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007008833	metal binding site [ion binding]; metal-binding site
561007008834	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007008835	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
561007008836	probable active site [active]
561007008837	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
561007008838	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
561007008839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008840	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007008841	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007008842	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
561007008843	putative active site pocket [active]
561007008844	dimerization interface [polypeptide binding]; other site
561007008845	putative catalytic residue [active]
561007008846	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
561007008847	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
561007008848	metal binding site [ion binding]; metal-binding site
561007008849	putative dimer interface [polypeptide binding]; other site
561007008850	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
561007008851	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
561007008852	metal binding site [ion binding]; metal-binding site
561007008853	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
561007008854	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
561007008855	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
561007008856	active site
561007008857	substrate binding site [chemical binding]; other site
561007008858	metal binding site [ion binding]; metal-binding site
561007008859	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007008860	active site
561007008861	NlpC/P60 family; Region: NLPC_P60; cl11438
561007008862	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
561007008863	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
561007008864	active site
561007008865	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
561007008866	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
561007008867	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
561007008868	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
561007008869	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
561007008870	active site
561007008871	catalytic motif [active]
561007008872	Zn binding site [ion binding]; other site
561007008873	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
561007008874	putative Iron-sulfur protein interface [polypeptide binding]; other site
561007008875	putative proximal heme binding site [chemical binding]; other site
561007008876	putative SdhD-like interface [polypeptide binding]; other site
561007008877	putative distal heme binding site [chemical binding]; other site
561007008878	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
561007008879	putative Iron-sulfur protein interface [polypeptide binding]; other site
561007008880	putative proximal heme binding site [chemical binding]; other site
561007008881	putative SdhC-like subunit interface [polypeptide binding]; other site
561007008882	putative distal heme binding site [chemical binding]; other site
561007008883	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
561007008884	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007008885	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
561007008886	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
561007008887	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
561007008888	Uncharacterized conserved protein [Function unknown]; Region: COG2128
561007008889	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007008890	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
561007008891	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007008892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007008893	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007008894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
561007008895	binding surface
561007008896	TPR motif; other site
561007008897	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
561007008898	Strictosidine synthase; Region: Str_synth; pfam03088
561007008899	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
561007008900	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007008901	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
561007008902	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
561007008903	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
561007008904	active site
561007008905	HIGH motif; other site
561007008906	dimer interface [polypeptide binding]; other site
561007008907	KMSKS motif; other site
561007008908	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
561007008909	putative active site [active]
561007008910	putative catalytic site [active]
561007008911	putative DNA binding site [nucleotide binding]; other site
561007008912	putative phosphate binding site [ion binding]; other site
561007008913	metal binding site A [ion binding]; metal-binding site
561007008914	putative AP binding site [nucleotide binding]; other site
561007008915	putative metal binding site B [ion binding]; other site
561007008916	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007008917	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
561007008918	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
561007008919	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
561007008920	homodimer interface [polypeptide binding]; other site
561007008921	substrate-cofactor binding pocket; other site
561007008922	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007008923	catalytic residue [active]
561007008924	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007008925	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
561007008926	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007008927	S-adenosylmethionine binding site [chemical binding]; other site
561007008928	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
561007008929	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
561007008930	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
561007008931	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
561007008932	homodimer interface [polypeptide binding]; other site
561007008933	NADP binding site [chemical binding]; other site
561007008934	substrate binding site [chemical binding]; other site
561007008935	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
561007008936	FMN binding site [chemical binding]; other site
561007008937	dimer interface [polypeptide binding]; other site
561007008938	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
561007008939	active site
561007008940	FMN binding site [chemical binding]; other site
561007008941	substrate binding site [chemical binding]; other site
561007008942	putative catalytic residue [active]
561007008943	Helix-turn-helix domains; Region: HTH; cl00088
561007008944	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
561007008945	NADH(P)-binding; Region: NAD_binding_10; pfam13460
561007008946	NAD binding site [chemical binding]; other site
561007008947	substrate binding site [chemical binding]; other site
561007008948	putative active site [active]
561007008949	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
561007008950	phosphopeptide binding site; other site
561007008951	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
561007008952	YppG-like protein; Region: YppG; pfam14179
561007008953	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
561007008954	phosphopeptide binding site; other site
561007008955	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
561007008956	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
561007008957	Walker A/P-loop; other site
561007008958	ATP binding site [chemical binding]; other site
561007008959	Q-loop/lid; other site
561007008960	ABC transporter signature motif; other site
561007008961	Walker B; other site
561007008962	D-loop; other site
561007008963	H-loop/switch region; other site
561007008964	ABC-2 type transporter; Region: ABC2_membrane; cl11417
561007008965	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
561007008966	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
561007008967	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
561007008968	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
561007008969	Helix-turn-helix domain; Region: HTH_18; pfam12833
561007008970	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007008971	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
561007008972	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
561007008973	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
561007008974	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
561007008975	generic binding surface II; other site
561007008976	generic binding surface I; other site
561007008977	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
561007008978	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
561007008979	Helix-turn-helix domains; Region: HTH; cl00088
561007008980	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
561007008981	active site
561007008982	NTP binding site [chemical binding]; other site
561007008983	metal binding triad [ion binding]; metal-binding site
561007008984	antibiotic binding site [chemical binding]; other site
561007008985	Bacterial PH domain; Region: DUF304; cl01348
561007008986	short chain dehydrogenase; Provisional; Region: PRK07201
561007008987	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
561007008988	putative NAD(P) binding site [chemical binding]; other site
561007008989	active site
561007008990	putative substrate binding site [chemical binding]; other site
561007008991	classical (c) SDRs; Region: SDR_c; cd05233
561007008992	NAD(P) binding site [chemical binding]; other site
561007008993	active site
561007008994	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
561007008995	active site
561007008996	DNA Polymerase Y-family; Region: PolY_like; cd03468
561007008997	active site
561007008998	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
561007008999	DNA binding site [nucleotide binding]
561007009000	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
561007009001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007009002	active site
561007009003	phosphorylation site [posttranslational modification]
561007009004	intermolecular recognition site; other site
561007009005	dimerization interface [polypeptide binding]; other site
561007009006	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007009007	DNA binding residues [nucleotide binding]
561007009008	dimerization interface [polypeptide binding]; other site
561007009009	PspC domain; Region: PspC; cl00864
561007009010	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
561007009011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007009012	ATP binding site [chemical binding]; other site
561007009013	Mg2+ binding site [ion binding]; other site
561007009014	G-X-G motif; other site
561007009015	PspC domain; Region: PspC; cl00864
561007009016	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
561007009017	GMP synthase; Reviewed; Region: guaA; PRK00074
561007009018	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
561007009019	AMP/PPi binding site [chemical binding]; other site
561007009020	candidate oxyanion hole; other site
561007009021	catalytic triad [active]
561007009022	potential glutamine specificity residues [chemical binding]; other site
561007009023	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
561007009024	ATP Binding subdomain [chemical binding]; other site
561007009025	Ligand Binding sites [chemical binding]; other site
561007009026	Dimerization subdomain; other site
561007009027	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
561007009028	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009030	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
561007009031	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
561007009032	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
561007009033	active site
561007009034	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
561007009035	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
561007009036	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
561007009037	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
561007009038	active site
561007009039	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
561007009040	metal binding site [ion binding]; metal-binding site
561007009041	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
561007009042	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007009043	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007009044	DNA binding residues [nucleotide binding]
561007009045	Transcription factor WhiB; Region: Whib; pfam02467
561007009046	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
561007009047	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
561007009048	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
561007009049	ring oligomerisation interface [polypeptide binding]; other site
561007009050	ATP/Mg binding site [chemical binding]; other site
561007009051	stacking interactions; other site
561007009052	hinge regions; other site
561007009053	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
561007009054	oligomerisation interface [polypeptide binding]; other site
561007009055	mobile loop; other site
561007009056	roof hairpin; other site
561007009057	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007009058	UGMP family protein; Validated; Region: PRK09604
561007009059	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
561007009060	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007009061	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
561007009062	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
561007009063	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009064	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007009065	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009066	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
561007009067	alanine racemase; Reviewed; Region: alr; PRK00053
561007009068	active site
561007009069	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
561007009070	dimer interface [polypeptide binding]; other site
561007009071	substrate binding site [chemical binding]; other site
561007009072	catalytic residues [active]
561007009073	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
561007009074	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
561007009075	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007009076	catalytic residue [active]
561007009077	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
561007009078	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
561007009079	putative substrate binding site [chemical binding]; other site
561007009080	putative ATP binding site [chemical binding]; other site
561007009081	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007009082	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
561007009083	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
561007009084	glutaminase active site [active]
561007009085	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
561007009086	dimer interface [polypeptide binding]; other site
561007009087	active site
561007009088	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
561007009089	dimer interface [polypeptide binding]; other site
561007009090	active site
561007009091	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
561007009092	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007009093	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
561007009094	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
561007009095	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
561007009096	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
561007009097	putative active site [active]
561007009098	putative metal binding site [ion binding]; other site
561007009099	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
561007009100	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
561007009101	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
561007009102	active site
561007009103	substrate binding site [chemical binding]; other site
561007009104	metal binding site [ion binding]; metal-binding site
561007009105	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
561007009106	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
561007009107	23S rRNA interface [nucleotide binding]; other site
561007009108	L3 interface [polypeptide binding]; other site
561007009109	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007009110	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007009111	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
561007009112	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
561007009113	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007009114	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
561007009115	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007009116	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007009117	Ubiquitin-like proteins; Region: UBQ; cl00155
561007009118	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
561007009119	active site
561007009120	catalytic residues [active]
561007009121	Protein of unknown function (DUF690); Region: DUF690; cl04939
561007009122	Protein of unknown function (DUF2984); Region: DUF2984; cl12752
561007009123	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
561007009124	CGNR zinc finger; Region: zf-CGNR; pfam11706
561007009125	EamA-like transporter family; Region: EamA; cl01037
561007009126	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
561007009127	EamA-like transporter family; Region: EamA; cl01037
561007009128	Cutinase; Region: Cutinase; pfam01083
561007009129	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007009130	Cutinase; Region: Cutinase; pfam01083
561007009131	Cutinase; Region: Cutinase; pfam01083
561007009132	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
561007009133	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
561007009134	dimerization interface 3.5A [polypeptide binding]; other site
561007009135	active site
561007009136	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
561007009137	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
561007009138	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
561007009139	alphaNTD homodimer interface [polypeptide binding]; other site
561007009140	alphaNTD - beta interaction site [polypeptide binding]; other site
561007009141	alphaNTD - beta' interaction site [polypeptide binding]; other site
561007009142	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
561007009143	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
561007009144	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
561007009145	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
561007009146	RNA binding surface [nucleotide binding]; other site
561007009147	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
561007009148	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
561007009149	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
561007009150	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
561007009151	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
561007009152	rRNA binding site [nucleotide binding]; other site
561007009153	predicted 30S ribosome binding site; other site
561007009154	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
561007009155	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
561007009157	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
561007009158	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007009159	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
561007009160	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
561007009161	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
561007009162	NAD binding site [chemical binding]; other site
561007009163	substrate binding site [chemical binding]; other site
561007009164	homodimer interface [polypeptide binding]; other site
561007009165	active site
561007009166	Cupin domain; Region: Cupin_2; cl09118
561007009167	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
561007009168	Septum formation; Region: Septum_form; pfam13845
561007009169	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
561007009170	active site
561007009171	adenylate kinase; Reviewed; Region: adk; PRK00279
561007009172	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
561007009173	AMP-binding site [chemical binding]; other site
561007009174	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
561007009175	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
561007009176	SecY translocase; Region: SecY; pfam00344
561007009177	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007009178	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007009179	Domain of unknown function DUF20; Region: UPF0118; pfam01594
561007009180	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
561007009181	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
561007009182	tandem repeat interface [polypeptide binding]; other site
561007009183	oligomer interface [polypeptide binding]; other site
561007009184	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
561007009185	active site residues [active]
561007009186	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
561007009187	tandem repeat interface [polypeptide binding]; other site
561007009188	oligomer interface [polypeptide binding]; other site
561007009189	active site residues [active]
561007009190	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007009191	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
561007009192	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
561007009193	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
561007009194	23S rRNA binding site [nucleotide binding]; other site
561007009195	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
561007009196	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
561007009197	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
561007009198	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
561007009199	5S rRNA interface [nucleotide binding]; other site
561007009200	L27 interface [polypeptide binding]; other site
561007009201	23S rRNA interface [nucleotide binding]; other site
561007009202	L5 interface [polypeptide binding]; other site
561007009203	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
561007009204	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
561007009205	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
561007009206	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
561007009207	glutamate dehydrogenase; Provisional; Region: PRK09414
561007009208	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
561007009209	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
561007009210	NAD(P) binding site [chemical binding]; other site
561007009211	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009212	Carboxylesterase family; Region: COesterase; pfam00135
561007009213	substrate binding pocket [chemical binding]; other site
561007009214	catalytic triad [active]
561007009215	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
561007009216	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
561007009217	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
561007009218	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
561007009219	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
561007009220	KOW motif; Region: KOW; cl00354
561007009221	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
561007009222	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
561007009223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007009224	putative substrate translocation pore; other site
561007009225	Cutinase; Region: Cutinase; pfam01083
561007009226	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
561007009227	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009228	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009229	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
561007009230	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
561007009231	putative translocon interaction site; other site
561007009232	23S rRNA interface [nucleotide binding]; other site
561007009233	signal recognition particle (SRP54) interaction site; other site
561007009234	L23 interface [polypeptide binding]; other site
561007009235	trigger factor interaction site; other site
561007009236	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
561007009237	23S rRNA interface [nucleotide binding]; other site
561007009238	5S rRNA interface [nucleotide binding]; other site
561007009239	putative antibiotic binding site [chemical binding]; other site
561007009240	L25 interface [polypeptide binding]; other site
561007009241	L27 interface [polypeptide binding]; other site
561007009242	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
561007009243	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
561007009244	G-X-X-G motif; other site
561007009245	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
561007009246	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
561007009247	putative translocon binding site; other site
561007009248	protein-rRNA interface [nucleotide binding]; other site
561007009249	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
561007009250	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
561007009251	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
561007009252	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
561007009253	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
561007009254	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
561007009255	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
561007009256	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
561007009257	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
561007009258	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007009259	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
561007009260	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007009261	CoenzymeA binding site [chemical binding]; other site
561007009262	subunit interaction site [polypeptide binding]; other site
561007009263	PHB binding site; other site
561007009264	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007009265	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
561007009266	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007009267	active site
561007009268	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
561007009269	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
561007009270	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
561007009271	ethanolamine permease; Region: 2A0305; TIGR00908
561007009272	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
561007009273	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
561007009274	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
561007009275	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
561007009276	Probable Catalytic site; other site
561007009277	metal-binding site
561007009278	Creatinine amidohydrolase; Region: Creatininase; cl00618
561007009279	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
561007009280	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
561007009281	phosphate binding site [ion binding]; other site
561007009282	mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962
561007009283	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
561007009284	FeS/SAM binding site; other site
561007009285	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
561007009286	mycofactocin system RPExFGAL protein; Region: Ac_RPExFGAL; TIGR03967
561007009287	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
561007009288	Helix-turn-helix domains; Region: HTH; cl00088
561007009289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
561007009290	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007009291	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
561007009292	Helix-turn-helix domains; Region: HTH; cl00088
561007009293	AsnC family; Region: AsnC_trans_reg; pfam01037
561007009294	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
561007009295	Amidinotransferase; Region: Amidinotransf; cl12043
561007009296	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
561007009297	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007009298	inhibitor-cofactor binding pocket; inhibition site
561007009299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007009300	catalytic residue [active]
561007009301	amino acid transporter; Region: 2A0306; TIGR00909
561007009302	Spore germination protein; Region: Spore_permease; cl15802
561007009303	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007009304	Ligand Binding Site [chemical binding]; other site
561007009305	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007009306	Ligand Binding Site [chemical binding]; other site
561007009307	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
561007009308	classical (c) SDRs; Region: SDR_c; cd05233
561007009309	NAD(P) binding site [chemical binding]; other site
561007009310	active site
561007009311	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
561007009312	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007009313	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007009314	elongation factor Tu; Reviewed; Region: PRK00049
561007009315	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
561007009316	G1 box; other site
561007009317	GEF interaction site [polypeptide binding]; other site
561007009318	GTP/Mg2+ binding site [chemical binding]; other site
561007009319	Switch I region; other site
561007009320	G2 box; other site
561007009321	G3 box; other site
561007009322	Switch II region; other site
561007009323	G4 box; other site
561007009324	G5 box; other site
561007009325	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
561007009326	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
561007009327	Antibiotic Binding Site [chemical binding]; other site
561007009328	elongation factor G; Reviewed; Region: PRK00007
561007009329	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
561007009330	G1 box; other site
561007009331	putative GEF interaction site [polypeptide binding]; other site
561007009332	GTP/Mg2+ binding site [chemical binding]; other site
561007009333	Switch I region; other site
561007009334	G2 box; other site
561007009335	G3 box; other site
561007009336	Switch II region; other site
561007009337	G4 box; other site
561007009338	G5 box; other site
561007009339	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
561007009340	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
561007009341	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
561007009342	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
561007009343	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
561007009344	S17 interaction site [polypeptide binding]; other site
561007009345	S8 interaction site; other site
561007009346	16S rRNA interaction site [nucleotide binding]; other site
561007009347	streptomycin interaction site [chemical binding]; other site
561007009348	23S rRNA interaction site [nucleotide binding]; other site
561007009349	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
561007009350	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009351	Helix-turn-helix domains; Region: HTH; cl00088
561007009352	WHG domain; Region: WHG; pfam13305
561007009353	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
561007009354	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
561007009355	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007009356	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007009357	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
561007009358	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007009359	substrate binding site [chemical binding]; other site
561007009360	oxyanion hole (OAH) forming residues; other site
561007009361	trimer interface [polypeptide binding]; other site
561007009362	PaaX-like protein; Region: PaaX; pfam07848
561007009363	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
561007009364	enoyl-CoA hydratase; Provisional; Region: PRK12478
561007009365	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007009366	substrate binding site [chemical binding]; other site
561007009367	oxyanion hole (OAH) forming residues; other site
561007009368	trimer interface [polypeptide binding]; other site
561007009369	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
561007009370	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007009371	active site
561007009372	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007009373	dimerization interface [polypeptide binding]; other site
561007009374	putative DNA binding site [nucleotide binding]; other site
561007009375	putative Zn2+ binding site [ion binding]; other site
561007009376	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
561007009377	putative hydrophobic ligand binding site [chemical binding]; other site
561007009378	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
561007009379	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
561007009380	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
561007009381	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
561007009382	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
561007009383	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
561007009384	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
561007009385	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
561007009386	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
561007009387	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
561007009388	DNA binding site [nucleotide binding]
561007009389	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
561007009390	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
561007009391	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
561007009392	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
561007009393	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
561007009394	RPB1 interaction site [polypeptide binding]; other site
561007009395	RPB10 interaction site [polypeptide binding]; other site
561007009396	RPB11 interaction site [polypeptide binding]; other site
561007009397	RPB3 interaction site [polypeptide binding]; other site
561007009398	RPB12 interaction site [polypeptide binding]; other site
561007009399	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
561007009400	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
561007009401	molybdopterin cofactor binding site; other site
561007009402	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
561007009403	molybdopterin cofactor binding site; other site
561007009404	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
561007009405	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
561007009406	Walker A/P-loop; other site
561007009407	ATP binding site [chemical binding]; other site
561007009408	Q-loop/lid; other site
561007009409	ABC transporter signature motif; other site
561007009410	Walker B; other site
561007009411	D-loop; other site
561007009412	H-loop/switch region; other site
561007009413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007009414	putative substrate translocation pore; other site
561007009415	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
561007009416	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
561007009417	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
561007009418	Helix-turn-helix domains; Region: HTH; cl00088
561007009419	WHG domain; Region: WHG; pfam13305
561007009420	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
561007009421	core dimer interface [polypeptide binding]; other site
561007009422	peripheral dimer interface [polypeptide binding]; other site
561007009423	L10 interface [polypeptide binding]; other site
561007009424	L11 interface [polypeptide binding]; other site
561007009425	putative EF-Tu interaction site [polypeptide binding]; other site
561007009426	putative EF-G interaction site [polypeptide binding]; other site
561007009427	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
561007009428	23S rRNA interface [nucleotide binding]; other site
561007009429	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
561007009430	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007009431	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009432	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
561007009433	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007009434	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
561007009435	active site
561007009436	ATP binding site [chemical binding]; other site
561007009437	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007009438	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009439	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009440	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
561007009441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007009442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007009443	S-adenosylmethionine binding site [chemical binding]; other site
561007009444	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
561007009445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009446	Helix-turn-helix domains; Region: HTH; cl00088
561007009447	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
561007009448	FAD binding domain; Region: FAD_binding_4; pfam01565
561007009449	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
561007009450	diacylglycerol kinase; Reviewed; Region: PRK11914
561007009451	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007009452	YCII-related domain; Region: YCII; cl00999
561007009453	YCII-related domain; Region: YCII; cl00999
561007009454	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
561007009455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007009456	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
561007009457	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
561007009458	GAF domain; Region: GAF; cl15785
561007009459	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
561007009460	Histidine kinase; Region: HisKA_3; pfam07730
561007009461	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
561007009462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007009463	active site
561007009464	phosphorylation site [posttranslational modification]
561007009465	intermolecular recognition site; other site
561007009466	dimerization interface [polypeptide binding]; other site
561007009467	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007009468	DNA binding residues [nucleotide binding]
561007009469	dimerization interface [polypeptide binding]; other site
561007009470	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
561007009471	mRNA/rRNA interface [nucleotide binding]; other site
561007009472	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
561007009473	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
561007009474	23S rRNA interface [nucleotide binding]; other site
561007009475	L7/L12 interface [polypeptide binding]; other site
561007009476	putative thiostrepton binding site; other site
561007009477	L25 interface [polypeptide binding]; other site
561007009478	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
561007009479	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
561007009480	putative homodimer interface [polypeptide binding]; other site
561007009481	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
561007009482	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
561007009483	active site
561007009484	catalytic site [active]
561007009485	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007009486	active site 2 [active]
561007009487	active site 1 [active]
561007009488	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
561007009489	active site
561007009490	catalytic site [active]
561007009491	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
561007009492	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
561007009493	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
561007009494	dimerization interface [polypeptide binding]; other site
561007009495	DPS ferroxidase diiron center [ion binding]; other site
561007009496	ion pore; other site
561007009497	intracellular protease, PfpI family; Region: PfpI; TIGR01382
561007009498	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
561007009499	proposed catalytic triad [active]
561007009500	conserved cys residue [active]
561007009501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
561007009502	Predicted kinase [General function prediction only]; Region: COG0645
561007009503	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007009504	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
561007009505	FMN binding site [chemical binding]; other site
561007009506	dimer interface [polypeptide binding]; other site
561007009507	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007009508	Ligand Binding Site [chemical binding]; other site
561007009509	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
561007009510	Predicted ATPase [General function prediction only]; Region: COG3899
561007009511	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007009512	DNA binding residues [nucleotide binding]
561007009513	dimerization interface [polypeptide binding]; other site
561007009514	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
561007009515	putative heme binding pocket [chemical binding]; other site
561007009516	Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818
561007009517	putative heme binding site [chemical binding]; other site
561007009518	putative active site [active]
561007009519	putative substrate binding site [chemical binding]; other site
561007009520	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
561007009521	active site
561007009522	catalytic triad [active]
561007009523	Protein of unknown function (DUF520); Region: DUF520; cl00723
561007009524	LysE type translocator; Region: LysE; cl00565
561007009525	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
561007009526	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
561007009527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009528	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
561007009529	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
561007009530	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
561007009531	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
561007009532	FAD binding pocket [chemical binding]; other site
561007009533	FAD binding motif [chemical binding]; other site
561007009534	phosphate binding motif [ion binding]; other site
561007009535	beta-alpha-beta structure motif; other site
561007009536	NAD(p) ribose binding residues [chemical binding]; other site
561007009537	NAD binding pocket [chemical binding]; other site
561007009538	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
561007009539	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007009540	catalytic loop [active]
561007009541	iron binding site [ion binding]; other site
561007009542	short chain dehydrogenase; Provisional; Region: PRK07832
561007009543	classical (c) SDRs; Region: SDR_c; cd05233
561007009544	NAD(P) binding site [chemical binding]; other site
561007009545	active site
561007009546	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009547	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009548	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007009549	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007009550	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009551	Helix-turn-helix domains; Region: HTH; cl00088
561007009552	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007009553	CoenzymeA binding site [chemical binding]; other site
561007009554	subunit interaction site [polypeptide binding]; other site
561007009555	PHB binding site; other site
561007009556	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
561007009557	TIGR03086 family protein; Region: TIGR03086
561007009558	Peptidase family M48; Region: Peptidase_M48; cl12018
561007009559	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
561007009560	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
561007009561	substrate binding pocket [chemical binding]; other site
561007009562	chain length determination region; other site
561007009563	substrate-Mg2+ binding site; other site
561007009564	catalytic residues [active]
561007009565	aspartate-rich region 1; other site
561007009566	active site lid residues [active]
561007009567	aspartate-rich region 2; other site
561007009568	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
561007009569	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
561007009570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007009571	S-adenosylmethionine binding site [chemical binding]; other site
561007009572	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
561007009573	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
561007009574	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
561007009575	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
561007009576	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
561007009577	dimer interface [polypeptide binding]; other site
561007009578	tetramer interface [polypeptide binding]; other site
561007009579	PYR/PP interface [polypeptide binding]; other site
561007009580	TPP binding site [chemical binding]; other site
561007009581	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
561007009582	TPP-binding site; other site
561007009583	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007009584	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009585	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009586	O-succinylbenzoate synthase; Provisional; Region: PRK02901
561007009587	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
561007009588	active site
561007009589	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007009590	catalytic core [active]
561007009591	Clp amino terminal domain; Region: Clp_N; pfam02861
561007009592	Clp amino terminal domain; Region: Clp_N; pfam02861
561007009593	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007009594	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
561007009595	metal binding site [ion binding]; metal-binding site
561007009596	active site
561007009597	I-site; other site
561007009598	Pirin-related protein [General function prediction only]; Region: COG1741
561007009599	Cupin domain; Region: Cupin_2; cl09118
561007009600	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
561007009601	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007009602	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007009603	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
561007009604	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007009605	substrate binding site [chemical binding]; other site
561007009606	oxyanion hole (OAH) forming residues; other site
561007009607	trimer interface [polypeptide binding]; other site
561007009608	short chain dehydrogenase; Provisional; Region: PRK08278
561007009609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009610	NAD(P) binding site [chemical binding]; other site
561007009611	active site
561007009612	short chain dehydrogenase; Provisional; Region: PRK05866
561007009613	classical (c) SDRs; Region: SDR_c; cd05233
561007009614	NAD(P) binding site [chemical binding]; other site
561007009615	active site
561007009616	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007009617	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
561007009618	active site
561007009619	metal binding site [ion binding]; metal-binding site
561007009620	Phosphate transporter family; Region: PHO4; cl00396
561007009621	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
561007009622	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
561007009623	AMP-binding enzyme; Region: AMP-binding; cl15778
561007009624	AMP-binding enzyme; Region: AMP-binding; cl15778
561007009625	Cupin domain; Region: Cupin_2; cl09118
561007009626	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
561007009627	hydrophobic ligand binding site; other site
561007009628	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007009629	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
561007009630	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
561007009631	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
561007009632	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
561007009633	UbiA prenyltransferase family; Region: UbiA; cl00337
561007009634	Clp amino terminal domain; Region: Clp_N; pfam02861
561007009635	Clp amino terminal domain; Region: Clp_N; pfam02861
561007009636	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007009637	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007009638	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007009639	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007009640	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
561007009641	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
561007009642	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007009643	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007009644	catalytic residue [active]
561007009645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009646	NAD(P) binding site [chemical binding]; other site
561007009647	active site
561007009648	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009649	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
561007009650	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
561007009651	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
561007009652	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
561007009653	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
561007009654	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
561007009655	ResB-like family; Region: ResB; pfam05140
561007009656	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007009657	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
561007009658	catalytic residues [active]
561007009659	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
561007009660	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007009661	catalytic core [active]
561007009662	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
561007009663	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007009664	inhibitor-cofactor binding pocket; inhibition site
561007009665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007009666	catalytic residue [active]
561007009667	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007009668	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007009669	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
561007009670	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
561007009671	active site
561007009672	Zn binding site [ion binding]; other site
561007009673	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
561007009674	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
561007009675	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
561007009676	metal-binding site [ion binding]
561007009677	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
561007009678	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007009679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007009680	S-adenosylmethionine binding site [chemical binding]; other site
561007009681	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
561007009682	dimer interface [polypeptide binding]; other site
561007009683	active site
561007009684	Schiff base residues; other site
561007009685	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
561007009686	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
561007009687	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
561007009688	active site
561007009689	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
561007009690	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
561007009691	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
561007009692	domain interfaces; other site
561007009693	active site
561007009694	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
561007009695	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
561007009696	tRNA; other site
561007009697	putative tRNA binding site [nucleotide binding]; other site
561007009698	putative NADP binding site [chemical binding]; other site
561007009699	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
561007009700	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007009701	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
561007009702	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007009703	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007009704	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
561007009705	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007009706	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007009707	Uncharacterized conserved protein [Function unknown]; Region: COG5361
561007009708	Protein of unknown function (DUF1254); Region: DUF1254; cl02257
561007009709	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
561007009710	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
561007009711	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
561007009712	FMN binding site [chemical binding]; other site
561007009713	substrate binding site [chemical binding]; other site
561007009714	putative catalytic residue [active]
561007009715	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
561007009716	putative acyl-acceptor binding pocket; other site
561007009717	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
561007009718	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
561007009719	putative NAD(P) binding site [chemical binding]; other site
561007009720	active site
561007009721	putative substrate binding site [chemical binding]; other site
561007009722	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007009723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009724	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
561007009725	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007009726	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
561007009727	active site
561007009728	diiron metal binding site [ion binding]; other site
561007009729	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007009730	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007009731	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
561007009732	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
561007009733	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
561007009734	Metal-binding active site; metal-binding site
561007009735	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
561007009736	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
561007009737	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
561007009738	putative hydrophobic ligand binding site [chemical binding]; other site
561007009739	protein interface [polypeptide binding]; other site
561007009740	gate; other site
561007009741	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009742	Methyltransferase domain; Region: Methyltransf_31; pfam13847
561007009743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007009744	S-adenosylmethionine binding site [chemical binding]; other site
561007009745	short chain dehydrogenase; Validated; Region: PRK05855
561007009746	classical (c) SDRs; Region: SDR_c; cd05233
561007009747	NAD(P) binding site [chemical binding]; other site
561007009748	active site
561007009749	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
561007009750	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
561007009751	FMN-binding pocket [chemical binding]; other site
561007009752	flavin binding motif; other site
561007009753	phosphate binding motif [ion binding]; other site
561007009754	beta-alpha-beta structure motif; other site
561007009755	NAD binding pocket [chemical binding]; other site
561007009756	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
561007009757	catalytic loop [active]
561007009758	iron binding site [ion binding]; other site
561007009759	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007009760	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007009761	short chain dehydrogenase; Provisional; Region: PRK06181
561007009762	classical (c) SDRs; Region: SDR_c; cd05233
561007009763	NAD(P) binding site [chemical binding]; other site
561007009764	active site
561007009765	short chain dehydrogenase; Provisional; Region: PRK07825
561007009766	classical (c) SDRs; Region: SDR_c; cd05233
561007009767	NAD(P) binding site [chemical binding]; other site
561007009768	active site
561007009769	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009770	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007009771	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009772	Helix-turn-helix domains; Region: HTH; cl00088
561007009773	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009774	Helix-turn-helix domains; Region: HTH; cl00088
561007009775	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
561007009776	Permease; Region: Permease; cl00510
561007009777	Permease; Region: Permease; cl00510
561007009778	mce related protein; Region: MCE; pfam02470
561007009779	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007009780	mce related protein; Region: MCE; pfam02470
561007009781	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007009782	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007009783	mce related protein; Region: MCE; pfam02470
561007009784	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
561007009785	Heterokaryon incompatibility protein Het-C; Region: Het-C; pfam07217
561007009786	mce related protein; Region: MCE; pfam02470
561007009787	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
561007009788	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007009789	mce related protein; Region: MCE; pfam02470
561007009790	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
561007009791	putative hydrophobic ligand binding site [chemical binding]; other site
561007009792	protein interface [polypeptide binding]; other site
561007009793	gate; other site
561007009794	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009796	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007009797	hydrophobic ligand binding site; other site
561007009798	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009799	short chain dehydrogenase; Provisional; Region: PRK07825
561007009800	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009801	NAD(P) binding site [chemical binding]; other site
561007009802	active site
561007009803	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007009804	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007009805	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
561007009806	active site
561007009807	ATP binding site [chemical binding]; other site
561007009808	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009809	Helix-turn-helix domains; Region: HTH; cl00088
561007009810	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009811	Helix-turn-helix domains; Region: HTH; cl00088
561007009812	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007009813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007009814	active site
561007009815	phosphorylation site [posttranslational modification]
561007009816	intermolecular recognition site; other site
561007009817	dimerization interface [polypeptide binding]; other site
561007009818	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007009819	DNA binding site [nucleotide binding]
561007009820	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
561007009821	dimer interface [polypeptide binding]; other site
561007009822	phosphorylation site [posttranslational modification]
561007009823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007009824	ATP binding site [chemical binding]; other site
561007009825	Mg2+ binding site [ion binding]; other site
561007009826	G-X-G motif; other site
561007009827	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007009828	catalytic core [active]
561007009829	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
561007009830	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009832	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007009833	dinuclear metal binding motif [ion binding]; other site
561007009834	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007009835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009836	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007009837	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
561007009838	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
561007009839	classical (c) SDRs; Region: SDR_c; cd05233
561007009840	NAD(P) binding site [chemical binding]; other site
561007009841	active site
561007009842	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007009843	4-coumarate--CoA ligase; Region: PLN02246
561007009844	AMP-binding enzyme; Region: AMP-binding; cl15778
561007009845	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007009846	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
561007009847	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
561007009848	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
561007009849	putative ADP-binding pocket [chemical binding]; other site
561007009850	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
561007009851	hydrophobic ligand binding site; other site
561007009852	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
561007009853	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
561007009854	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009855	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
561007009856	NAD(P) binding site [chemical binding]; other site
561007009857	active site
561007009858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
561007009859	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
561007009860	Helix-turn-helix domains; Region: HTH; cl00088
561007009861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007009862	putative substrate translocation pore; other site
561007009863	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
561007009864	FAD binding domain; Region: FAD_binding_4; pfam01565
561007009865	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
561007009866	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
561007009867	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
561007009868	CHAT domain; Region: CHAT; pfam12770
561007009869	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
561007009870	Predicted amidohydrolase [General function prediction only]; Region: COG0388
561007009871	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
561007009872	putative active site [active]
561007009873	catalytic triad [active]
561007009874	putative dimer interface [polypeptide binding]; other site
561007009875	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
561007009876	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
561007009877	intersubunit interface [polypeptide binding]; other site
561007009878	active site
561007009879	catalytic residue [active]
561007009880	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
561007009881	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
561007009882	tetramer interface [polypeptide binding]; other site
561007009883	active site
561007009884	Mg2+/Mn2+ binding site [ion binding]; other site
561007009885	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
561007009886	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
561007009887	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
561007009888	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007009889	non-specific DNA binding site [nucleotide binding]; other site
561007009890	salt bridge; other site
561007009891	sequence-specific DNA binding site [nucleotide binding]; other site
561007009892	Predicted membrane protein [Function unknown]; Region: COG2733
561007009893	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007009894	Helix-turn-helix domains; Region: HTH; cl00088
561007009895	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
561007009896	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
561007009897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007009898	S-adenosylmethionine binding site [chemical binding]; other site
561007009899	Helix-turn-helix domains; Region: HTH; cl00088
561007009900	Spore germination protein; Region: Spore_permease; cl15802
561007009901	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
561007009902	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
561007009903	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
561007009904	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
561007009905	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
561007009906	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
561007009907	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
561007009908	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
561007009909	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
561007009910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009911	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
561007009912	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
561007009913	tetramer interface [polypeptide binding]; other site
561007009914	active site
561007009915	Mg2+/Mn2+ binding site [ion binding]; other site
561007009916	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
561007009917	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007009918	active site 2 [active]
561007009919	active site 1 [active]
561007009920	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007009921	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007009922	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
561007009923	AMP-binding enzyme; Region: AMP-binding; cl15778
561007009924	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007009925	Condensation domain; Region: Condensation; pfam00668
561007009926	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007009927	peptide synthase; Provisional; Region: PRK12467
561007009928	AMP-binding enzyme; Region: AMP-binding; cl15778
561007009929	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007009930	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
561007009931	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
561007009932	putative NAD(P) binding site [chemical binding]; other site
561007009933	active site
561007009934	putative substrate binding site [chemical binding]; other site
561007009935	peptide synthase; Provisional; Region: PRK12316
561007009936	AMP-binding enzyme; Region: AMP-binding; cl15778
561007009937	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007009938	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007009939	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007009940	AMP-binding enzyme; Region: AMP-binding; cl15778
561007009941	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007009942	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007009943	Condensation domain; Region: Condensation; pfam00668
561007009944	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
561007009945	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007009946	MbtH-like protein; Region: MbtH; cl01279
561007009947	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
561007009948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007009949	S-adenosylmethionine binding site [chemical binding]; other site
561007009950	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
561007009951	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
561007009952	homodimer interface [polypeptide binding]; other site
561007009953	active site
561007009954	TDP-binding site; other site
561007009955	acceptor substrate-binding pocket; other site
561007009956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007009957	OpgC protein; Region: OpgC_C; cl00792
561007009958	Acyltransferase family; Region: Acyl_transf_3; pfam01757
561007009959	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
561007009960	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
561007009961	homodimer interface [polypeptide binding]; other site
561007009962	active site
561007009963	TDP-binding site; other site
561007009964	acceptor substrate-binding pocket; other site
561007009965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007009966	Methyltransferase domain; Region: Methyltransf_31; pfam13847
561007009967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007009968	OpgC protein; Region: OpgC_C; cl00792
561007009969	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
561007009970	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007009971	NAD(P) binding site [chemical binding]; other site
561007009972	active site
561007009973	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
561007009974	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
561007009975	homodimer interface [polypeptide binding]; other site
561007009976	active site
561007009977	TDP-binding site; other site
561007009978	acceptor substrate-binding pocket; other site
561007009979	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
561007009980	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
561007009981	substrate binding site; other site
561007009982	tetramer interface; other site
561007009983	Transport protein; Region: actII; TIGR00833
561007009984	Transport protein; Region: actII; TIGR00833
561007009985	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007009986	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
561007009987	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007009988	non-specific DNA binding site [nucleotide binding]; other site
561007009989	salt bridge; other site
561007009990	sequence-specific DNA binding site [nucleotide binding]; other site
561007009991	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
561007009992	Domain of unknown function (DUF955); Region: DUF955; cl01076
561007009993	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
561007009994	Uncharacterized conserved protein [Function unknown]; Region: COG2128
561007009995	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007009996	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
561007009997	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
561007009998	active site
561007009999	catalytic tetrad [active]
561007010000	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
561007010001	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
561007010002	DNA binding residues [nucleotide binding]
561007010003	putative dimer interface [polypeptide binding]; other site
561007010004	Spore germination protein; Region: Spore_permease; cl15802
561007010005	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007010006	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
561007010007	active site
561007010008	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007010009	hypothetical protein; Provisional; Region: PRK01346
561007010010	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
561007010011	non-prolyl cis peptide bond; other site
561007010012	active site
561007010013	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
561007010014	active site clefts [active]
561007010015	zinc binding site [ion binding]; other site
561007010016	dimer interface [polypeptide binding]; other site
561007010017	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
561007010018	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010019	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007010020	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007010021	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
561007010022	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007010023	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007010024	Secretory lipase; Region: LIP; pfam03583
561007010025	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007010026	active site
561007010027	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007010028	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
561007010029	NAD(P) binding site [chemical binding]; other site
561007010030	catalytic residues [active]
561007010031	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007010032	DinB superfamily; Region: DinB_2; pfam12867
561007010033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007010034	putative substrate translocation pore; other site
561007010035	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007010036	dimerization interface [polypeptide binding]; other site
561007010037	putative DNA binding site [nucleotide binding]; other site
561007010038	putative Zn2+ binding site [ion binding]; other site
561007010039	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
561007010040	putative hydrophobic ligand binding site [chemical binding]; other site
561007010041	PE-PPE domain; Region: PE-PPE; pfam08237
561007010042	YHYH protein; Region: YHYH; pfam14240
561007010043	Cupin domain; Region: Cupin_2; cl09118
561007010044	Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982
561007010045	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
561007010046	active site
561007010047	homotetramer interface [polypeptide binding]; other site
561007010048	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010049	mce related protein; Region: MCE; pfam02470
561007010050	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010051	mce related protein; Region: MCE; pfam02470
561007010052	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010053	mce related protein; Region: MCE; pfam02470
561007010054	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010055	mce related protein; Region: MCE; pfam02470
561007010056	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
561007010057	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010058	mce related protein; Region: MCE; pfam02470
561007010059	mce related protein; Region: MCE; pfam02470
561007010060	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
561007010061	Permease; Region: Permease; cl00510
561007010062	Permease; Region: Permease; cl00510
561007010063	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
561007010064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010065	NAD(P) binding site [chemical binding]; other site
561007010066	active site
561007010067	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
561007010068	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007010069	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
561007010070	FAD binding site [chemical binding]; other site
561007010071	substrate binding site [chemical binding]; other site
561007010072	catalytic base [active]
561007010073	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007010074	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007010075	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
561007010076	active site
561007010077	acyl-CoA synthetase; Validated; Region: PRK07867
561007010078	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010079	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010080	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
561007010081	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
561007010082	Nitronate monooxygenase; Region: NMO; pfam03060
561007010083	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
561007010084	FMN binding site [chemical binding]; other site
561007010085	substrate binding site [chemical binding]; other site
561007010086	putative catalytic residue [active]
561007010087	acyl-CoA synthetase; Validated; Region: PRK07798
561007010088	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010089	enoyl-CoA hydratase; Provisional; Region: PRK07799
561007010090	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007010091	substrate binding site [chemical binding]; other site
561007010092	oxyanion hole (OAH) forming residues; other site
561007010093	trimer interface [polypeptide binding]; other site
561007010094	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
561007010095	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
561007010096	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
561007010097	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
561007010098	DUF35 OB-fold domain; Region: DUF35; pfam01796
561007010099	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
561007010100	DUF35 OB-fold domain; Region: DUF35; pfam01796
561007010101	lipid-transfer protein; Provisional; Region: PRK07937
561007010102	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007010103	active site
561007010104	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
561007010105	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
561007010106	active site
561007010107	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007010108	ferredoxin-NADP+ reductase; Region: PLN02852
561007010109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010110	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
561007010111	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
561007010112	trimer interface [polypeptide binding]; other site
561007010113	putative metal binding site [ion binding]; other site
561007010114	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
561007010115	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
561007010116	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
561007010117	putative active site [active]
561007010118	dimerization interface [polypeptide binding]; other site
561007010119	putative tRNAtyr binding site [nucleotide binding]; other site
561007010120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
561007010121	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010122	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
561007010123	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
561007010124	classical (c) SDRs; Region: SDR_c; cd05233
561007010125	NAD(P) binding site [chemical binding]; other site
561007010126	active site
561007010127	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007010128	Helix-turn-helix domains; Region: HTH; cl00088
561007010129	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
561007010130	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
561007010131	Active Sites [active]
561007010132	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
561007010133	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
561007010134	CysD dimerization site [polypeptide binding]; other site
561007010135	G1 box; other site
561007010136	putative GEF interaction site [polypeptide binding]; other site
561007010137	GTP/Mg2+ binding site [chemical binding]; other site
561007010138	Switch I region; other site
561007010139	G2 box; other site
561007010140	G3 box; other site
561007010141	Switch II region; other site
561007010142	G4 box; other site
561007010143	G5 box; other site
561007010144	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
561007010145	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
561007010146	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
561007010147	ligand-binding site [chemical binding]; other site
561007010148	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
561007010149	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
561007010150	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
561007010151	E-class dimer interface [polypeptide binding]; other site
561007010152	P-class dimer interface [polypeptide binding]; other site
561007010153	active site
561007010154	Cu2+ binding site [ion binding]; other site
561007010155	Zn2+ binding site [ion binding]; other site
561007010156	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
561007010157	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
561007010158	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
561007010159	active site
561007010160	catalytic residues [active]
561007010161	metal binding site [ion binding]; metal-binding site
561007010162	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007010163	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
561007010164	putative catalytic site [active]
561007010165	putative phosphate binding site [ion binding]; other site
561007010166	active site
561007010167	metal binding site A [ion binding]; metal-binding site
561007010168	DNA binding site [nucleotide binding]
561007010169	putative AP binding site [nucleotide binding]; other site
561007010170	putative metal binding site B [ion binding]; other site
561007010171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007010172	putative substrate translocation pore; other site
561007010173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007010174	putative substrate translocation pore; other site
561007010175	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
561007010176	ThiC-associated domain; Region: ThiC-associated; pfam13667
561007010177	ThiC family; Region: ThiC; cl08031
561007010178	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
561007010179	dimer interface [polypeptide binding]; other site
561007010180	substrate binding site [chemical binding]; other site
561007010181	ATP binding site [chemical binding]; other site
561007010182	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
561007010183	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
561007010184	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007010185	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
561007010186	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007010187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007010188	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007010189	Helix-turn-helix domains; Region: HTH; cl00088
561007010190	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
561007010191	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
561007010192	Helix-turn-helix domains; Region: HTH; cl00088
561007010193	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007010194	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
561007010195	tetrameric interface [polypeptide binding]; other site
561007010196	NAD binding site [chemical binding]; other site
561007010197	catalytic residues [active]
561007010198	substrate binding site [chemical binding]; other site
561007010199	tyramine oxidase; Provisional; Region: tynA; PRK11504
561007010200	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
561007010201	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
561007010202	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
561007010203	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
561007010204	Ligand Binding Site [chemical binding]; other site
561007010205	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
561007010206	Spore germination protein; Region: Spore_permease; cl15802
561007010207	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
561007010208	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007010209	inhibitor-cofactor binding pocket; inhibition site
561007010210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007010211	catalytic residue [active]
561007010212	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007010213	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
561007010214	tetramerization interface [polypeptide binding]; other site
561007010215	NAD(P) binding site [chemical binding]; other site
561007010216	catalytic residues [active]
561007010217	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
561007010218	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
561007010219	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
561007010220	putative active site [active]
561007010221	putative CoA binding site [chemical binding]; other site
561007010222	nudix motif; other site
561007010223	metal binding site [ion binding]; metal-binding site
561007010224	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
561007010225	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
561007010226	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
561007010227	PA/protease or protease-like domain interface [polypeptide binding]; other site
561007010228	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
561007010229	active site
561007010230	metal binding site [ion binding]; metal-binding site
561007010231	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
561007010232	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
561007010233	PA/protease or protease-like domain interface [polypeptide binding]; other site
561007010234	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
561007010235	active site
561007010236	metal binding site [ion binding]; metal-binding site
561007010237	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
561007010238	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
561007010239	Walker A/P-loop; other site
561007010240	ATP binding site [chemical binding]; other site
561007010241	Q-loop/lid; other site
561007010242	ABC transporter signature motif; other site
561007010243	Walker B; other site
561007010244	D-loop; other site
561007010245	H-loop/switch region; other site
561007010246	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
561007010247	ThiS interaction site; other site
561007010248	putative active site [active]
561007010249	tetramer interface [polypeptide binding]; other site
561007010250	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
561007010251	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
561007010252	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
561007010253	thiamine phosphate binding site [chemical binding]; other site
561007010254	active site
561007010255	pyrophosphate binding site [ion binding]; other site
561007010256	PAS fold; Region: PAS_3; pfam08447
561007010257	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
561007010258	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
561007010259	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
561007010260	substrate binding pocket [chemical binding]; other site
561007010261	membrane-bound complex binding site; other site
561007010262	hinge residues; other site
561007010263	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
561007010264	Catalytic domain of Protein Kinases; Region: PKc; cd00180
561007010265	active site
561007010266	ATP binding site [chemical binding]; other site
561007010267	substrate binding site [chemical binding]; other site
561007010268	activation loop (A-loop); other site
561007010269	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
561007010270	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
561007010271	binding surface
561007010272	TPR motif; other site
561007010273	Acetokinase family; Region: Acetate_kinase; cl01029
561007010274	acetate kinase; Region: ackA; TIGR00016
561007010275	phosphate acetyltransferase; Reviewed; Region: PRK05632
561007010276	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007010277	DRTGG domain; Region: DRTGG; cl12147
561007010278	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
561007010279	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
561007010280	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
561007010281	active site
561007010282	catalytic site [active]
561007010283	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
561007010284	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007010285	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
561007010286	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007010287	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007010288	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
561007010289	active site
561007010290	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
561007010291	non-prolyl cis peptide bond; other site
561007010292	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007010293	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
561007010294	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007010295	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
561007010296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007010297	Coenzyme A binding pocket [chemical binding]; other site
561007010298	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
561007010299	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
561007010300	substrate binding pocket [chemical binding]; other site
561007010301	membrane-bound complex binding site; other site
561007010302	hinge residues; other site
561007010303	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
561007010304	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
561007010305	Walker A/P-loop; other site
561007010306	ATP binding site [chemical binding]; other site
561007010307	Q-loop/lid; other site
561007010308	ABC transporter signature motif; other site
561007010309	Walker B; other site
561007010310	D-loop; other site
561007010311	H-loop/switch region; other site
561007010312	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
561007010313	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007010314	dimer interface [polypeptide binding]; other site
561007010315	conserved gate region; other site
561007010316	putative PBP binding loops; other site
561007010317	ABC-ATPase subunit interface; other site
561007010318	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007010319	Transport protein; Region: actII; TIGR00833
561007010320	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
561007010321	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
561007010322	homodimer interface [polypeptide binding]; other site
561007010323	substrate-cofactor binding pocket; other site
561007010324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007010325	catalytic residue [active]
561007010326	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
561007010327	active site residue [active]
561007010328	phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142
561007010329	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007010330	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
561007010331	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
561007010332	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007010333	CoenzymeA binding site [chemical binding]; other site
561007010334	subunit interaction site [polypeptide binding]; other site
561007010335	PHB binding site; other site
561007010336	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
561007010337	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
561007010338	GDP-binding site [chemical binding]; other site
561007010339	ACT binding site; other site
561007010340	IMP binding site; other site
561007010341	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
561007010342	active site
561007010343	putative substrate binding region [chemical binding]; other site
561007010344	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
561007010345	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
561007010346	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
561007010347	active site
561007010348	intersubunit interface [polypeptide binding]; other site
561007010349	zinc binding site [ion binding]; other site
561007010350	Na+ binding site [ion binding]; other site
561007010351	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
561007010352	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
561007010353	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
561007010354	active site
561007010355	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
561007010356	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
561007010357	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007010358	active site
561007010359	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
561007010360	classical (c) SDRs; Region: SDR_c; cd05233
561007010361	NAD(P) binding site [chemical binding]; other site
561007010362	active site
561007010363	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007010364	Transport protein; Region: actII; TIGR00833
561007010365	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
561007010366	Clp amino terminal domain; Region: Clp_N; pfam02861
561007010367	Clp amino terminal domain; Region: Clp_N; pfam02861
561007010368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007010369	Walker A motif; other site
561007010370	ATP binding site [chemical binding]; other site
561007010371	Walker B motif; other site
561007010372	arginine finger; other site
561007010373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
561007010374	Walker A motif; other site
561007010375	ATP binding site [chemical binding]; other site
561007010376	Walker B motif; other site
561007010377	arginine finger; other site
561007010378	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
561007010379	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
561007010380	putative hydrophobic ligand binding site [chemical binding]; other site
561007010381	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
561007010382	putative hydrophobic ligand binding site [chemical binding]; other site
561007010383	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
561007010384	putative hydrophobic ligand binding site [chemical binding]; other site
561007010385	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
561007010386	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
561007010387	heme-binding site [chemical binding]; other site
561007010388	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
561007010389	FAD binding pocket [chemical binding]; other site
561007010390	FAD binding motif [chemical binding]; other site
561007010391	phosphate binding motif [ion binding]; other site
561007010392	beta-alpha-beta structure motif; other site
561007010393	NAD binding pocket [chemical binding]; other site
561007010394	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
561007010395	DNA binding residues [nucleotide binding]
561007010396	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
561007010397	putative dimer interface [polypeptide binding]; other site
561007010398	chaperone protein DnaJ; Provisional; Region: PRK14279
561007010399	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
561007010400	HSP70 interaction site [polypeptide binding]; other site
561007010401	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
561007010402	Zn binding sites [ion binding]; other site
561007010403	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
561007010404	dimer interface [polypeptide binding]; other site
561007010405	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
561007010406	dimer interface [polypeptide binding]; other site
561007010407	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
561007010408	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
561007010409	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007010410	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
561007010411	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007010412	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007010413	G1 box; other site
561007010414	GTP/Mg2+ binding site [chemical binding]; other site
561007010415	G2 box; other site
561007010416	Switch I region; other site
561007010417	G3 box; other site
561007010418	Switch II region; other site
561007010419	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007010420	Dynamin family; Region: Dynamin_N; pfam00350
561007010421	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007010422	G1 box; other site
561007010423	G1 box; other site
561007010424	GTP/Mg2+ binding site [chemical binding]; other site
561007010425	GTP/Mg2+ binding site [chemical binding]; other site
561007010426	G2 box; other site
561007010427	Switch I region; other site
561007010428	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007010429	G3 box; other site
561007010430	G3 box; other site
561007010431	Switch II region; other site
561007010432	Switch II region; other site
561007010433	GTP/Mg2+ binding site [chemical binding]; other site
561007010434	G4 box; other site
561007010435	G5 box; other site
561007010436	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007010437	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
561007010438	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007010439	Helix-turn-helix domains; Region: HTH; cl00088
561007010440	Peptidase family M48; Region: Peptidase_M48; cl12018
561007010441	DoxX; Region: DoxX; cl00976
561007010442	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
561007010443	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
561007010444	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
561007010445	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007010446	dimerization interface [polypeptide binding]; other site
561007010447	DNA binding residues [nucleotide binding]
561007010448	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
561007010449	Cysteine-rich domain; Region: CCG; pfam02754
561007010450	Cysteine-rich domain; Region: CCG; pfam02754
561007010451	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
561007010452	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
561007010453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007010454	homodimer interface [polypeptide binding]; other site
561007010455	catalytic residue [active]
561007010456	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
561007010457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010458	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
561007010459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010460	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
561007010461	trimer interface [polypeptide binding]; other site
561007010462	active site
561007010463	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
561007010464	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
561007010465	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007010466	alpha-galactosidase; Region: PLN02229
561007010467	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
561007010468	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
561007010469	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
561007010470	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
561007010471	Sulfatase; Region: Sulfatase; cl10460
561007010472	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
561007010473	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
561007010474	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
561007010475	Transport protein; Region: actII; TIGR00833
561007010476	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007010477	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010478	Helix-turn-helix domains; Region: HTH; cl00088
561007010479	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010480	Helix-turn-helix domains; Region: HTH; cl00088
561007010481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010482	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
561007010483	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007010484	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
561007010485	NAD(P) binding site [chemical binding]; other site
561007010486	catalytic residues [active]
561007010487	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
561007010488	Spore germination protein; Region: Spore_permease; cl15802
561007010489	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007010490	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
561007010491	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007010492	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007010493	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007010494	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007010495	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010496	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
561007010497	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007010498	Zn binding site [ion binding]; other site
561007010499	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010500	Helix-turn-helix domains; Region: HTH; cl00088
561007010501	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
561007010502	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010503	short chain dehydrogenase; Provisional; Region: PRK12939
561007010504	classical (c) SDRs; Region: SDR_c; cd05233
561007010505	NAD(P) binding site [chemical binding]; other site
561007010506	active site
561007010507	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007010508	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
561007010509	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007010510	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
561007010511	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
561007010512	FAD binding site [chemical binding]; other site
561007010513	substrate binding site [chemical binding]; other site
561007010514	catalytic base [active]
561007010515	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007010516	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007010517	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
561007010518	putative hydrophobic ligand binding site [chemical binding]; other site
561007010519	Uncharacterized conserved protein [Function unknown]; Region: COG3268
561007010520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010521	NAD(P) binding pocket [chemical binding]; other site
561007010522	acyl-CoA synthetase; Validated; Region: PRK07788
561007010523	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010524	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007010525	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
561007010526	nucleotide binding site [chemical binding]; other site
561007010527	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
561007010528	nudix motif; other site
561007010529	Transcription factor WhiB; Region: Whib; pfam02467
561007010530	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
561007010531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010532	hypothetical protein; Provisional; Region: PRK06062
561007010533	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007010534	inhibitor-cofactor binding pocket; inhibition site
561007010535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007010536	catalytic residue [active]
561007010537	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
561007010538	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007010539	tetrameric interface [polypeptide binding]; other site
561007010540	NAD binding site [chemical binding]; other site
561007010541	catalytic residues [active]
561007010542	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
561007010543	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
561007010544	Helix-turn-helix domains; Region: HTH; cl00088
561007010545	Predicted amidohydrolase [General function prediction only]; Region: COG0388
561007010546	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
561007010547	putative active site [active]
561007010548	catalytic triad [active]
561007010549	putative dimer interface [polypeptide binding]; other site
561007010550	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
561007010551	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
561007010552	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
561007010553	Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978
561007010554	Secretory lipase; Region: LIP; pfam03583
561007010555	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010556	Helix-turn-helix domains; Region: HTH; cl00088
561007010557	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007010558	CoenzymeA binding site [chemical binding]; other site
561007010559	subunit interaction site [polypeptide binding]; other site
561007010560	PHB binding site; other site
561007010561	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
561007010562	putative FMN binding site [chemical binding]; other site
561007010563	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
561007010564	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007010565	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
561007010566	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
561007010567	dimer interface [polypeptide binding]; other site
561007010568	PYR/PP interface [polypeptide binding]; other site
561007010569	TPP binding site [chemical binding]; other site
561007010570	substrate binding site [chemical binding]; other site
561007010571	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
561007010572	TPP-binding site [chemical binding]; other site
561007010573	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
561007010574	hypothetical protein; Provisional; Region: PRK06126
561007010575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010576	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
561007010577	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007010578	putative active site [active]
561007010579	putative metal binding site [ion binding]; other site
561007010580	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010581	Helix-turn-helix domains; Region: HTH; cl00088
561007010582	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
561007010583	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007010584	AMP-binding domain protein; Validated; Region: PRK07529
561007010585	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007010587	non-specific DNA binding site [nucleotide binding]; other site
561007010588	salt bridge; other site
561007010589	sequence-specific DNA binding site [nucleotide binding]; other site
561007010590	Cupin domain; Region: Cupin_2; cl09118
561007010591	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
561007010592	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
561007010593	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010594	NAD(P) binding site [chemical binding]; other site
561007010595	active site
561007010596	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
561007010597	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
561007010598	inter-subunit interface; other site
561007010599	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
561007010600	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007010601	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
561007010602	[2Fe-2S] cluster binding site [ion binding]; other site
561007010603	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
561007010604	iron-sulfur cluster [ion binding]; other site
561007010605	[2Fe-2S] cluster binding site [ion binding]; other site
561007010606	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
561007010607	beta subunit interface [polypeptide binding]; other site
561007010608	alpha subunit interface [polypeptide binding]; other site
561007010609	active site
561007010610	substrate binding site [chemical binding]; other site
561007010611	Fe binding site [ion binding]; other site
561007010612	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
561007010613	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007010614	NAD(P) binding site [chemical binding]; other site
561007010615	Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365
561007010616	putative active site [active]
561007010617	Fe(II) binding site [ion binding]; other site
561007010618	putative dimer interface [polypeptide binding]; other site
561007010619	putative tetramer interface [polypeptide binding]; other site
561007010620	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
561007010621	acetaldehyde dehydrogenase; Validated; Region: PRK08300
561007010622	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010623	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
561007010624	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
561007010625	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
561007010626	active site
561007010627	catalytic residues [active]
561007010628	metal binding site [ion binding]; metal-binding site
561007010629	DmpG-like communication domain; Region: DmpG_comm; pfam07836
561007010630	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
561007010631	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
561007010632	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010633	AMP-binding domain protein; Validated; Region: PRK08315
561007010634	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010635	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007010636	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
561007010637	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
561007010638	putative active site [active]
561007010639	putative catalytic site [active]
561007010640	Helix-turn-helix domains; Region: HTH; cl00088
561007010641	Bacterial transcriptional regulator; Region: IclR; pfam01614
561007010642	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
561007010643	Helix-turn-helix domains; Region: HTH; cl00088
561007010644	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007010645	dimerization interface [polypeptide binding]; other site
561007010646	Transport protein; Region: actII; TIGR00833
561007010647	Snf7; Region: Snf7; cl02305
561007010648	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007010649	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010650	Helix-turn-helix domains; Region: HTH; cl00088
561007010651	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
561007010652	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010653	NAD(P) binding site [chemical binding]; other site
561007010654	active site
561007010655	LysE type translocator; Region: LysE; cl00565
561007010656	GXWXG protein; Region: GXWXG; pfam14231
561007010657	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
561007010658	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
561007010659	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
561007010660	catalytic Zn binding site [ion binding]; other site
561007010661	NAD binding site [chemical binding]; other site
561007010662	structural Zn binding site [ion binding]; other site
561007010663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010664	Helix-turn-helix domains; Region: HTH; cl00088
561007010665	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
561007010666	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
561007010667	intersubunit interface [polypeptide binding]; other site
561007010668	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
561007010669	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
561007010670	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
561007010671	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
561007010672	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007010673	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
561007010674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007010675	Helix-turn-helix domains; Region: HTH; cl00088
561007010676	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
561007010677	putative substrate binding pocket [chemical binding]; other site
561007010678	putative dimerization interface [polypeptide binding]; other site
561007010679	Uncharacterized conserved protein [Function unknown]; Region: COG3391
561007010680	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
561007010681	putative dimer interface [polypeptide binding]; other site
561007010682	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
561007010683	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
561007010684	homodimer interface [polypeptide binding]; other site
561007010685	putative substrate binding pocket [chemical binding]; other site
561007010686	diiron center [ion binding]; other site
561007010687	Cutinase; Region: Cutinase; pfam01083
561007010688	Cutinase; Region: Cutinase; pfam01083
561007010689	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
561007010690	Isochorismatase family; Region: Isochorismatase; pfam00857
561007010691	catalytic triad [active]
561007010692	conserved cis-peptide bond; other site
561007010693	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
561007010694	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007010695	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
561007010696	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
561007010697	dimer interface [polypeptide binding]; other site
561007010698	decamer (pentamer of dimers) interface [polypeptide binding]; other site
561007010699	catalytic triad [active]
561007010700	peroxidatic and resolving cysteines [active]
561007010701	Helix-turn-helix domains; Region: HTH; cl00088
561007010702	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
561007010703	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
561007010704	dimerization interface [polypeptide binding]; other site
561007010705	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
561007010706	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
561007010707	tetramer interface [polypeptide binding]; other site
561007010708	active site
561007010709	Mg2+/Mn2+ binding site [ion binding]; other site
561007010710	Transcriptional regulators [Transcription]; Region: GntR; COG1802
561007010711	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007010712	DNA-binding site [nucleotide binding]; DNA binding site
561007010713	FCD domain; Region: FCD; cl11656
561007010714	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
561007010715	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
561007010716	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
561007010717	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010718	putative amidase; Provisional; Region: PRK06169
561007010719	Amidase; Region: Amidase; cl11426
561007010720	Cyclophilin-like; Region: Cyclophil_like; cl00950
561007010721	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
561007010722	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
561007010723	inhibitor-cofactor binding pocket; inhibition site
561007010724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
561007010725	catalytic residue [active]
561007010726	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007010727	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
561007010728	tetramerization interface [polypeptide binding]; other site
561007010729	NAD(P) binding site [chemical binding]; other site
561007010730	catalytic residues [active]
561007010731	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
561007010732	tartrate dehydrogenase; Provisional; Region: PRK08194
561007010733	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
561007010734	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010735	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
561007010736	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
561007010737	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
561007010738	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007010739	hydrophobic ligand binding site; other site
561007010740	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007010741	dimerization interface [polypeptide binding]; other site
561007010742	putative DNA binding site [nucleotide binding]; other site
561007010743	putative Zn2+ binding site [ion binding]; other site
561007010744	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007010745	dimerization interface [polypeptide binding]; other site
561007010746	putative DNA binding site [nucleotide binding]; other site
561007010747	putative Zn2+ binding site [ion binding]; other site
561007010748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010749	NAD(P) binding site [chemical binding]; other site
561007010750	active site
561007010751	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
561007010752	Flavin Reductases; Region: FlaRed; cl00801
561007010753	enoyl-CoA hydratase; Provisional; Region: PRK07509
561007010754	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007010755	substrate binding site [chemical binding]; other site
561007010756	oxyanion hole (OAH) forming residues; other site
561007010757	trimer interface [polypeptide binding]; other site
561007010758	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
561007010759	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733
561007010760	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
561007010761	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
561007010762	Catalytic domain of Protein Kinases; Region: PKc; cd00180
561007010763	active site
561007010764	ATP binding site [chemical binding]; other site
561007010765	substrate binding site [chemical binding]; other site
561007010766	activation loop (A-loop); other site
561007010767	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007010768	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
561007010769	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
561007010770	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
561007010771	FAD binding site [chemical binding]; other site
561007010772	substrate binding site [chemical binding]; other site
561007010773	catalytic residues [active]
561007010774	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
561007010775	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007010776	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007010777	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
561007010778	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007010779	AAA domain; Region: AAA_18; pfam13238
561007010780	active site
561007010781	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
561007010782	Moco binding site; other site
561007010783	metal coordination site [ion binding]; other site
561007010784	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
561007010785	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
561007010786	dimer interface [polypeptide binding]; other site
561007010787	active site
561007010788	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
561007010789	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010790	NAD(P) binding site [chemical binding]; other site
561007010791	active site
561007010792	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007010793	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007010794	active site 2 [active]
561007010795	active site 1 [active]
561007010796	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
561007010797	TIGR03086 family protein; Region: TIGR03086
561007010798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007010799	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
561007010800	Sulfate transporter family; Region: Sulfate_transp; cl15842
561007010801	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
561007010802	Sulfate transporter family; Region: Sulfate_transp; cl15842
561007010803	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
561007010804	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010805	Helix-turn-helix domains; Region: HTH; cl00088
561007010806	Integral membrane protein TerC family; Region: TerC; cl10468
561007010807	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
561007010808	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007010809	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
561007010810	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
561007010811	DNA binding residues [nucleotide binding]
561007010812	YCII-related domain; Region: YCII; cl00999
561007010813	YCII-related domain; Region: YCII; cl00999
561007010814	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
561007010815	AMP-binding enzyme; Region: AMP-binding; cl15778
561007010816	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007010817	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007010818	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
561007010819	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
561007010820	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007010821	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007010822	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007010823	HEAT repeats; Region: HEAT_2; pfam13646
561007010824	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
561007010825	TfoX N-terminal domain; Region: TfoX_N; cl01167
561007010826	Sulfatase; Region: Sulfatase; cl10460
561007010827	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
561007010828	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
561007010829	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
561007010830	OpgC protein; Region: OpgC_C; cl00792
561007010831	Acyltransferase family; Region: Acyl_transf_3; pfam01757
561007010832	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
561007010833	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
561007010834	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010835	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
561007010836	dinuclear metal binding motif [ion binding]; other site
561007010837	classical (c) SDRs; Region: SDR_c; cd05233
561007010838	short chain dehydrogenase; Provisional; Region: PRK05650
561007010839	NAD(P) binding site [chemical binding]; other site
561007010840	active site
561007010841	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
561007010842	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
561007010843	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
561007010844	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007010845	S-adenosylmethionine binding site [chemical binding]; other site
561007010846	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
561007010847	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
561007010848	putative active site [active]
561007010849	putative substrate binding site [chemical binding]; other site
561007010850	ATP binding site [chemical binding]; other site
561007010851	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
561007010852	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
561007010853	NAD binding site [chemical binding]; other site
561007010854	catalytic residues [active]
561007010855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007010856	metabolite-proton symporter; Region: 2A0106; TIGR00883
561007010857	putative substrate translocation pore; other site
561007010858	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010859	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
561007010860	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
561007010861	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130
561007010862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010863	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
561007010864	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
561007010865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010866	NAD(P) binding site [chemical binding]; other site
561007010867	active site
561007010868	Putative cyclase; Region: Cyclase; cl00814
561007010869	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007010870	Helix-turn-helix domains; Region: HTH; cl00088
561007010871	Bacterial transcriptional regulator; Region: IclR; pfam01614
561007010872	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
561007010873	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
561007010874	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007010875	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
561007010876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007010877	active site
561007010878	phosphorylation site [posttranslational modification]
561007010879	intermolecular recognition site; other site
561007010880	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007010881	DNA binding residues [nucleotide binding]
561007010882	dimerization interface [polypeptide binding]; other site
561007010883	GAF domain; Region: GAF; cl15785
561007010884	Histidine kinase; Region: HisKA_3; pfam07730
561007010885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007010886	ATP binding site [chemical binding]; other site
561007010887	Mg2+ binding site [ion binding]; other site
561007010888	G-X-G motif; other site
561007010889	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
561007010890	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
561007010891	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
561007010892	active site
561007010893	substrate-binding site [chemical binding]; other site
561007010894	metal-binding site [ion binding]
561007010895	GTP binding site [chemical binding]; other site
561007010896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007010897	S-adenosylmethionine binding site [chemical binding]; other site
561007010898	LabA_like proteins; Region: LabA_like; cd06167
561007010899	putative metal binding site [ion binding]; other site
561007010900	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
561007010901	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
561007010902	Helix-turn-helix domains; Region: HTH; cl00088
561007010903	WHG domain; Region: WHG; pfam13305
561007010904	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010905	mce related protein; Region: MCE; pfam02470
561007010906	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010907	mce related protein; Region: MCE; pfam02470
561007010908	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
561007010909	mce related protein; Region: MCE; pfam02470
561007010910	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010911	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
561007010912	mce related protein; Region: MCE; pfam02470
561007010913	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007010914	mce related protein; Region: MCE; pfam02470
561007010915	mce related protein; Region: MCE; pfam02470
561007010916	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
561007010917	Permease; Region: Permease; cl00510
561007010918	Permease; Region: Permease; cl00510
561007010919	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
561007010920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007010921	active site
561007010922	phosphorylation site [posttranslational modification]
561007010923	intermolecular recognition site; other site
561007010924	dimerization interface [polypeptide binding]; other site
561007010925	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
561007010926	DNA binding residues [nucleotide binding]
561007010927	dimerization interface [polypeptide binding]; other site
561007010928	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
561007010929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
561007010930	ATP binding site [chemical binding]; other site
561007010931	Mg2+ binding site [ion binding]; other site
561007010932	G-X-G motif; other site
561007010933	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
561007010934	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007010935	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007010936	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
561007010937	dimerization interface [polypeptide binding]; other site
561007010938	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
561007010939	cyclase homology domain; Region: CHD; cd07302
561007010940	nucleotidyl binding site; other site
561007010941	metal binding site [ion binding]; metal-binding site
561007010942	dimer interface [polypeptide binding]; other site
561007010943	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
561007010944	YceI-like domain; Region: YceI; cl01001
561007010945	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
561007010946	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
561007010947	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007010948	Interferon-induced transmembrane protein; Region: CD225; pfam04505
561007010949	hypothetical protein; Provisional; Region: PRK01346
561007010950	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007010951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007010952	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
561007010953	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
561007010954	active site
561007010955	Zn binding site [ion binding]; other site
561007010956	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
561007010957	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007010958	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007010959	active site
561007010960	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
561007010961	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
561007010962	ATP-grasp domain; Region: ATP-grasp_4; cl03087
561007010963	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
561007010964	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
561007010965	carboxyltransferase (CT) interaction site; other site
561007010966	biotinylation site [posttranslational modification]; other site
561007010967	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
561007010968	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007010969	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007010970	Helix-turn-helix domains; Region: HTH; cl00088
561007010971	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
561007010972	putative homodimer interface [polypeptide binding]; other site
561007010973	putative homotetramer interface [polypeptide binding]; other site
561007010974	putative allosteric switch controlling residues; other site
561007010975	putative metal binding site [ion binding]; other site
561007010976	putative homodimer-homodimer interface [polypeptide binding]; other site
561007010977	Domain of unknown function (DUF305); Region: DUF305; cl15795
561007010978	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
561007010979	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
561007010980	Dehydratase family; Region: ILVD_EDD; cl00340
561007010981	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007010982	Helix-turn-helix domains; Region: HTH; cl00088
561007010983	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
561007010984	NAD(P) binding site [chemical binding]; other site
561007010985	catalytic residues [active]
561007010986	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
561007010987	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007010988	S-adenosylmethionine binding site [chemical binding]; other site
561007010989	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
561007010990	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
561007010991	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007010992	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
561007010993	RNA polymerase factor sigma-70; Validated; Region: PRK08241
561007010994	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007010995	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007010996	DNA binding residues [nucleotide binding]
561007010997	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
561007010998	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
561007010999	Zn binding site [ion binding]; other site
561007011000	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
561007011001	LemA family; Region: LemA; cl00742
561007011002	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
561007011003	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011004	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007011005	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
561007011006	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
561007011007	NAD binding site [chemical binding]; other site
561007011008	catalytic Zn binding site [ion binding]; other site
561007011009	substrate binding site [chemical binding]; other site
561007011010	structural Zn binding site [ion binding]; other site
561007011011	Pirin-related protein [General function prediction only]; Region: COG1741
561007011012	Cupin domain; Region: Cupin_2; cl09118
561007011013	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
561007011014	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011015	mce related protein; Region: MCE; pfam02470
561007011016	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011017	mce related protein; Region: MCE; pfam02470
561007011018	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011019	mce related protein; Region: MCE; pfam02470
561007011020	mce related protein; Region: MCE; pfam02470
561007011021	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011022	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011023	mce related protein; Region: MCE; pfam02470
561007011024	mce related protein; Region: MCE; pfam02470
561007011025	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011026	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
561007011027	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011028	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007011029	enoyl-CoA hydratase; Provisional; Region: PRK06688
561007011030	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007011031	substrate binding site [chemical binding]; other site
561007011032	oxyanion hole (OAH) forming residues; other site
561007011033	trimer interface [polypeptide binding]; other site
561007011034	Transcriptional regulators [Transcription]; Region: GntR; COG1802
561007011035	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007011036	DNA-binding site [nucleotide binding]; DNA binding site
561007011037	FCD domain; Region: FCD; cl11656
561007011038	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
561007011039	putative hydrophobic ligand binding site [chemical binding]; other site
561007011040	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007011041	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007011042	Helix-turn-helix domains; Region: HTH; cl00088
561007011043	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
561007011044	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
561007011045	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
561007011046	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
561007011047	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
561007011048	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
561007011049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011050	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
561007011051	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007011052	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
561007011053	putative dimer interface [polypeptide binding]; other site
561007011054	N-terminal domain interface [polypeptide binding]; other site
561007011055	putative substrate binding pocket (H-site) [chemical binding]; other site
561007011056	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007011057	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007011058	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007011059	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007011060	enoyl-CoA hydratase; Provisional; Region: PRK08252
561007011061	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
561007011062	substrate binding site [chemical binding]; other site
561007011063	oxyanion hole (OAH) forming residues; other site
561007011064	trimer interface [polypeptide binding]; other site
561007011065	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
561007011066	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
561007011067	putative active site [active]
561007011068	putative substrate binding site [chemical binding]; other site
561007011069	ATP binding site [chemical binding]; other site
561007011070	nucleoside transporter; Region: 2A0110; TIGR00889
561007011071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
561007011072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
561007011073	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
561007011074	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
561007011075	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
561007011076	Protein of unknown function (DUF456); Region: DUF456; cl01069
561007011077	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011078	mce related protein; Region: MCE; pfam02470
561007011079	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011080	mce related protein; Region: MCE; pfam02470
561007011081	mce related protein; Region: MCE; pfam02470
561007011082	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011083	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011084	mce related protein; Region: MCE; pfam02470
561007011085	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
561007011086	mce related protein; Region: MCE; pfam02470
561007011087	mce related protein; Region: MCE; pfam02470
561007011088	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
561007011089	Permease; Region: Permease; cl00510
561007011090	Permease; Region: Permease; cl00510
561007011091	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
561007011092	active site 2 [active]
561007011093	active site 1 [active]
561007011094	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
561007011095	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
561007011096	NAD(P) binding site [chemical binding]; other site
561007011097	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
561007011098	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
561007011099	NAD binding site [chemical binding]; other site
561007011100	homodimer interface [polypeptide binding]; other site
561007011101	active site
561007011102	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
561007011103	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
561007011104	NAD(P) binding site [chemical binding]; other site
561007011105	catalytic residues [active]
561007011106	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007011107	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007011108	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
561007011109	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
561007011110	dimer interface [polypeptide binding]; other site
561007011111	active site
561007011112	acyl-coenzyme A oxidase; Region: PLN02526
561007011113	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007011114	active site
561007011115	Leucine carboxyl methyltransferase; Region: LCM; cl01306
561007011116	Helix-turn-helix domains; Region: HTH; cl00088
561007011117	Domain of unknown function (DUF427); Region: DUF427; cl00998
561007011118	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
561007011119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007011120	S-adenosylmethionine binding site [chemical binding]; other site
561007011121	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007011122	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007011123	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007011124	sequence-specific DNA binding site [nucleotide binding]; other site
561007011125	salt bridge; other site
561007011126	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
561007011127	Domain of unknown function (DUF955); Region: DUF955; cl01076
561007011128	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
561007011129	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
561007011130	PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513
561007011131	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
561007011132	tetramer interface [polypeptide binding]; other site
561007011133	active site
561007011134	Mg2+/Mn2+ binding site [ion binding]; other site
561007011135	citrate synthase; Provisional; Region: PRK14033
561007011136	Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111
561007011137	dimer interface [polypeptide binding]; other site
561007011138	active site
561007011139	citrylCoA binding site [chemical binding]; other site
561007011140	oxalacetate/citrate binding site [chemical binding]; other site
561007011141	coenzyme A binding site [chemical binding]; other site
561007011142	catalytic triad [active]
561007011143	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
561007011144	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007011145	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
561007011146	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
561007011147	THF binding site; other site
561007011148	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
561007011149	substrate binding site [chemical binding]; other site
561007011150	THF binding site; other site
561007011151	zinc-binding site [ion binding]; other site
561007011152	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
561007011153	CoenzymeA binding site [chemical binding]; other site
561007011154	subunit interaction site [polypeptide binding]; other site
561007011155	PHB binding site; other site
561007011156	acyl-CoA synthetase; Validated; Region: PRK06188
561007011157	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011158	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011159	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
561007011160	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007011161	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
561007011162	active site
561007011163	metal binding site [ion binding]; metal-binding site
561007011164	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
561007011165	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
561007011166	Transcriptional regulator [Transcription]; Region: IclR; COG1414
561007011167	Helix-turn-helix domains; Region: HTH; cl00088
561007011168	short chain dehydrogenase; Provisional; Region: PRK07814
561007011169	classical (c) SDRs; Region: SDR_c; cd05233
561007011170	NAD(P) binding site [chemical binding]; other site
561007011171	active site
561007011172	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
561007011173	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007011174	Helix-turn-helix domains; Region: HTH; cl00088
561007011175	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
561007011176	putative active site [active]
561007011177	putative FMN binding site [chemical binding]; other site
561007011178	putative substrate binding site [chemical binding]; other site
561007011179	putative catalytic residue [active]
561007011180	Domain of unknown function (DUF385); Region: DUF385; cl04387
561007011181	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
561007011182	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
561007011183	dimer interface [polypeptide binding]; other site
561007011184	active site
561007011185	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
561007011186	galactokinase; Provisional; Region: PRK03817
561007011187	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
561007011188	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
561007011189	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
561007011190	putative transporter; Provisional; Region: PRK10484
561007011191	Na binding site [ion binding]; other site
561007011192	Dehydratase family; Region: ILVD_EDD; cl00340
561007011193	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007011194	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
561007011195	dimer interface [polypeptide binding]; other site
561007011196	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
561007011197	active site
561007011198	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
561007011199	substrate binding site [chemical binding]; other site
561007011200	catalytic residue [active]
561007011201	putative amidase; Provisional; Region: PRK06169
561007011202	Amidase; Region: Amidase; cl11426
561007011203	Transcriptional regulators [Transcription]; Region: FadR; COG2186
561007011204	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
561007011205	DNA-binding site [nucleotide binding]; DNA binding site
561007011206	FCD domain; Region: FCD; cl11656
561007011207	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
561007011208	Helix-turn-helix domains; Region: HTH; cl00088
561007011209	Helix-turn-helix domains; Region: HTH; cl00088
561007011210	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
561007011211	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
561007011212	active site
561007011213	catalytic residues [active]
561007011214	metal binding site [ion binding]; metal-binding site
561007011215	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
561007011216	CoA-transferase family III; Region: CoA_transf_3; pfam02515
561007011217	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
561007011218	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007011219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007011220	DNA binding residues [nucleotide binding]
561007011221	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
561007011222	iron-sulfur cluster [ion binding]; other site
561007011223	[2Fe-2S] cluster binding site [ion binding]; other site
561007011224	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
561007011225	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
561007011226	active site
561007011227	metal binding site [ion binding]; metal-binding site
561007011228	short chain dehydrogenase; Provisional; Region: PRK12744
561007011229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011230	NAD(P) binding site [chemical binding]; other site
561007011231	active site
561007011232	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
561007011233	Helix-turn-helix domains; Region: HTH; cl00088
561007011234	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007011235	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007011236	active site
561007011237	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
561007011238	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
561007011239	CGNR zinc finger; Region: zf-CGNR; pfam11706
561007011240	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
561007011241	classical (c) SDRs; Region: SDR_c; cd05233
561007011242	NAD(P) binding site [chemical binding]; other site
561007011243	active site
561007011244	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
561007011245	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
561007011246	active site
561007011247	acyl-CoA synthetase; Validated; Region: PRK09192
561007011248	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011249	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011250	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
561007011251	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
561007011252	Walker A/P-loop; other site
561007011253	ATP binding site [chemical binding]; other site
561007011254	Q-loop/lid; other site
561007011255	ABC transporter signature motif; other site
561007011256	Walker B; other site
561007011257	D-loop; other site
561007011258	H-loop/switch region; other site
561007011259	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
561007011260	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
561007011261	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
561007011262	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
561007011263	catalytic residue [active]
561007011264	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
561007011265	trimerization site [polypeptide binding]; other site
561007011266	active site
561007011267	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011268	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
561007011269	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
561007011270	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007011271	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
561007011272	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
561007011273	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011274	NAD(P) binding site [chemical binding]; other site
561007011275	active site
561007011276	NlpC/P60 family; Region: NLPC_P60; cl11438
561007011277	transcriptional regulator BetI; Validated; Region: PRK00767
561007011278	Helix-turn-helix domains; Region: HTH; cl00088
561007011279	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
561007011280	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
561007011281	TDP-binding site; other site
561007011282	tetracycline repressor protein TetR; Provisional; Region: PRK13756
561007011283	Helix-turn-helix domains; Region: HTH; cl00088
561007011284	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
561007011285	Phospholipid methyltransferase; Region: PEMT; cl00763
561007011286	peptide synthase; Provisional; Region: PRK12467
561007011287	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011288	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011289	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007011290	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011291	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011292	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007011293	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007011294	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011295	peptide synthase; Provisional; Region: PRK12316
561007011296	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011297	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011298	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011299	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007011300	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011301	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011302	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011303	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007011304	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011305	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011306	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007011307	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007011308	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011309	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011310	peptide synthase; Provisional; Region: PRK12467
561007011311	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007011312	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011313	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011314	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007011315	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011316	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011317	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
561007011318	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
561007011319	MbtH-like protein; Region: MbtH; cl01279
561007011320	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007011321	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
561007011322	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
561007011323	homodimer interface [polypeptide binding]; other site
561007011324	active site
561007011325	TDP-binding site; other site
561007011326	acceptor substrate-binding pocket; other site
561007011327	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
561007011328	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
561007011329	homodimer interface [polypeptide binding]; other site
561007011330	active site
561007011331	TDP-binding site; other site
561007011332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007011333	S-adenosylmethionine binding site [chemical binding]; other site
561007011334	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007011335	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
561007011336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
561007011337	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007011338	S-adenosylmethionine binding site [chemical binding]; other site
561007011339	Transport protein; Region: actII; TIGR00833
561007011340	Transport protein; Region: actII; TIGR00833
561007011341	Protein export membrane protein; Region: SecD_SecF; cl14618
561007011342	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007011343	Secretory lipase; Region: LIP; pfam03583
561007011344	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
561007011345	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007011346	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
561007011347	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007011348	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
561007011349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011350	NAD(P) binding site [chemical binding]; other site
561007011351	active site
561007011352	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007011353	Helix-turn-helix domain; Region: HTH_18; pfam12833
561007011354	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
561007011355	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
561007011356	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
561007011357	AMP-binding enzyme; Region: AMP-binding; cl15778
561007011358	Phosphopantetheine attachment site; Region: PP-binding; cl09936
561007011359	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
561007011360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011361	NAD(P) binding site [chemical binding]; other site
561007011362	active site
561007011363	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007011364	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
561007011365	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
561007011366	potassium/proton antiporter; Reviewed; Region: PRK05326
561007011367	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
561007011368	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
561007011369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011370	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
561007011371	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
561007011372	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
561007011373	DNA binding residues [nucleotide binding]
561007011374	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
561007011375	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
561007011376	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007011377	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
561007011378	Restriction endonuclease; Region: Mrr_cat; cl00516
561007011379	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
561007011380	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
561007011381	putative DNA binding site [nucleotide binding]; other site
561007011382	catalytic residue [active]
561007011383	putative H2TH interface [polypeptide binding]; other site
561007011384	putative catalytic residues [active]
561007011385	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
561007011386	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
561007011387	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
561007011388	Membrane transport protein; Region: Mem_trans; cl09117
561007011389	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007011390	Helix-turn-helix domains; Region: HTH; cl00088
561007011391	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007011392	dimerization interface [polypeptide binding]; other site
561007011393	DoxX; Region: DoxX; cl00976
561007011394	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
561007011395	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007011396	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007011397	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
561007011398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011399	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
561007011400	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
561007011401	dimerization interface [polypeptide binding]; other site
561007011402	DPS ferroxidase diiron center [ion binding]; other site
561007011403	ion pore; other site
561007011404	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
561007011405	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
561007011406	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
561007011407	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
561007011408	metal binding site [ion binding]; metal-binding site
561007011409	putative dimer interface [polypeptide binding]; other site
561007011410	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
561007011411	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
561007011412	active site
561007011413	catalytic residues [active]
561007011414	DoxX; Region: DoxX; cl00976
561007011415	TQO small subunit DoxA; Region: DoxA; pfam07680
561007011416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007011417	S-adenosylmethionine binding site [chemical binding]; other site
561007011418	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
561007011419	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007011420	Transport protein; Region: actII; TIGR00833
561007011421	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
561007011422	putative homotetramer interface [polypeptide binding]; other site
561007011423	putative homodimer interface [polypeptide binding]; other site
561007011424	putative allosteric switch controlling residues; other site
561007011425	putative metal binding site [ion binding]; other site
561007011426	putative homodimer-homodimer interface [polypeptide binding]; other site
561007011427	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007011428	TetR family transcriptional regulator; Provisional; Region: PRK14996
561007011429	Helix-turn-helix domains; Region: HTH; cl00088
561007011430	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
561007011431	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011432	NAD(P) binding site [chemical binding]; other site
561007011433	active site
561007011434	hypothetical protein; Provisional; Region: PRK10279
561007011435	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
561007011436	nucleophile elbow; other site
561007011437	Domain of unknown function (DUF222); Region: DUF222; pfam02720
561007011438	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
561007011439	active site
561007011440	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007011441	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
561007011442	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
561007011443	conserved cys residue [active]
561007011444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
561007011445	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007011446	hypothetical protein; Provisional; Region: PRK06185
561007011447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011448	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007011449	Helix-turn-helix domains; Region: HTH; cl00088
561007011450	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
561007011451	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
561007011452	active site
561007011453	nucleophile elbow; other site
561007011454	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
561007011455	FMN binding site [chemical binding]; other site
561007011456	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
561007011457	dimer interface [polypeptide binding]; other site
561007011458	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007011459	Walker A/P-loop; other site
561007011460	ATP binding site [chemical binding]; other site
561007011461	Q-loop/lid; other site
561007011462	ABC transporter signature motif; other site
561007011463	Walker B; other site
561007011464	D-loop; other site
561007011465	Predicted membrane protein [Function unknown]; Region: COG1511
561007011466	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
561007011467	ABC-2 type transporter; Region: ABC2_membrane; cl11417
561007011468	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
561007011469	Helix-turn-helix domains; Region: HTH; cl00088
561007011470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007011471	Cupin domain; Region: Cupin_2; cl09118
561007011472	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
561007011473	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
561007011474	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
561007011475	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
561007011476	Transport protein; Region: actII; TIGR00833
561007011477	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
561007011478	cyclase homology domain; Region: CHD; cd07302
561007011479	nucleotidyl binding site; other site
561007011480	metal binding site [ion binding]; metal-binding site
561007011481	dimer interface [polypeptide binding]; other site
561007011482	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
561007011483	Helix-turn-helix domains; Region: HTH; cl00088
561007011484	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
561007011485	heme binding pocket [chemical binding]; other site
561007011486	heme ligand [chemical binding]; other site
561007011487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
561007011488	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
561007011489	Helix-turn-helix domains; Region: HTH; cl00088
561007011490	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
561007011491	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
561007011492	active site
561007011493	catalytic site [active]
561007011494	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
561007011495	active site
561007011496	catalytic site [active]
561007011497	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
561007011498	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007011499	Walker A/P-loop; other site
561007011500	ATP binding site [chemical binding]; other site
561007011501	Q-loop/lid; other site
561007011502	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
561007011503	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
561007011504	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
561007011505	active site
561007011506	PPE family; Region: PPE; pfam00823
561007011507	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
561007011508	Helix-turn-helix domains; Region: HTH; cl00088
561007011509	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
561007011510	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007011511	Alkylmercury lyase; Region: MerB; pfam03243
561007011512	short chain dehydrogenase; Provisional; Region: PRK05866
561007011513	classical (c) SDRs; Region: SDR_c; cd05233
561007011514	NAD(P) binding site [chemical binding]; other site
561007011515	active site
561007011516	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
561007011517	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007011518	Helix-turn-helix domain; Region: HTH_18; pfam12833
561007011519	Transcriptional regulator [Transcription]; Region: LysR; COG0583
561007011520	Helix-turn-helix domains; Region: HTH; cl00088
561007011521	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
561007011522	dimerization interface [polypeptide binding]; other site
561007011523	substrate binding pocket [chemical binding]; other site
561007011524	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
561007011525	Esterase/lipase [General function prediction only]; Region: COG1647
561007011526	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
561007011527	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007011528	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
561007011529	S-adenosylmethionine binding site [chemical binding]; other site
561007011530	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007011531	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
561007011532	active site
561007011533	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
561007011534	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007011535	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
561007011536	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
561007011537	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
561007011538	Putative esterase; Region: Esterase; pfam00756
561007011539	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007011540	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
561007011541	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
561007011542	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
561007011543	catalytic residues [active]
561007011544	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
561007011545	Tetratricopeptide repeat; Region: TPR_12; pfam13424
561007011546	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
561007011547	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
561007011548	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
561007011549	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
561007011550	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
561007011551	ATP binding site [chemical binding]; other site
561007011552	putative Mg++ binding site [ion binding]; other site
561007011553	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
561007011554	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007011555	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007011556	Proteins of 100 residues with WXG; Region: WXG100; cl02005
561007011557	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
561007011558	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007011559	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
561007011560	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
561007011561	active site
561007011562	substrate binding site [chemical binding]; other site
561007011563	ATP binding site [chemical binding]; other site
561007011564	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
561007011565	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
561007011566	Major Facilitator Superfamily; Region: MFS_1; pfam07690
561007011567	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
561007011568	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007011569	dimerization interface [polypeptide binding]; other site
561007011570	putative DNA binding site [nucleotide binding]; other site
561007011571	putative Zn2+ binding site [ion binding]; other site
561007011572	Low molecular weight phosphatase family; Region: LMWPc; cd00115
561007011573	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
561007011574	active site
561007011575	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
561007011576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007011577	dimerization interface [polypeptide binding]; other site
561007011578	putative DNA binding site [nucleotide binding]; other site
561007011579	putative Zn2+ binding site [ion binding]; other site
561007011580	Low molecular weight phosphatase family; Region: LMWPc; cl00105
561007011581	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
561007011582	active site
561007011583	Phosphate transporter family; Region: PHO4; cl00396
561007011584	Helicase associated domain; Region: HA; pfam03457
561007011585	Helicase associated domain; Region: HA; pfam03457
561007011586	Helicase associated domain; Region: HA; pfam03457
561007011587	Helicase associated domain; Region: HA; pfam03457
561007011588	Helicase associated domain; Region: HA; pfam03457
561007011589	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
561007011590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
561007011591	active site
561007011592	phosphorylation site [posttranslational modification]
561007011593	intermolecular recognition site; other site
561007011594	dimerization interface [polypeptide binding]; other site
561007011595	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
561007011596	DNA binding site [nucleotide binding]
561007011597	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
561007011598	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
561007011599	Walker A/P-loop; other site
561007011600	ATP binding site [chemical binding]; other site
561007011601	Q-loop/lid; other site
561007011602	ABC transporter signature motif; other site
561007011603	Walker B; other site
561007011604	D-loop; other site
561007011605	H-loop/switch region; other site
561007011606	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
561007011607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007011608	dimer interface [polypeptide binding]; other site
561007011609	conserved gate region; other site
561007011610	putative PBP binding loops; other site
561007011611	ABC-ATPase subunit interface; other site
561007011612	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
561007011613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
561007011614	dimer interface [polypeptide binding]; other site
561007011615	conserved gate region; other site
561007011616	putative PBP binding loops; other site
561007011617	ABC-ATPase subunit interface; other site
561007011618	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
561007011619	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
561007011620	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
561007011621	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007011622	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007011623	dimerization interface [polypeptide binding]; other site
561007011624	putative DNA binding site [nucleotide binding]; other site
561007011625	putative Zn2+ binding site [ion binding]; other site
561007011626	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
561007011627	Helix-turn-helix domains; Region: HTH; cl00088
561007011628	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
561007011629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007011630	dimerization interface [polypeptide binding]; other site
561007011631	putative DNA binding site [nucleotide binding]; other site
561007011632	putative Zn2+ binding site [ion binding]; other site
561007011633	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
561007011634	dimerization interface [polypeptide binding]; other site
561007011635	putative DNA binding site [nucleotide binding]; other site
561007011636	putative Zn2+ binding site [ion binding]; other site
561007011637	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
561007011638	Membrane transport protein; Region: Mem_trans; cl09117
561007011639	Low molecular weight phosphatase family; Region: LMWPc; cl00105
561007011640	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
561007011641	active site
561007011642	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
561007011643	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007011644	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
561007011645	BCCT family transporter; Region: BCCT; cl00569
561007011646	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
561007011647	trimer interface [polypeptide binding]; other site
561007011648	active site
561007011649	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007011650	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
561007011651	sequence-specific DNA binding site [nucleotide binding]; other site
561007011652	salt bridge; other site
561007011653	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007011654	active site
561007011655	DNA binding site [nucleotide binding]
561007011656	Int/Topo IB signature motif; other site
561007011657	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
561007011658	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
561007011659	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
561007011660	active site
561007011661	DNA binding site [nucleotide binding]
561007011662	Int/Topo IB signature motif; other site
561007011663	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
561007011664	Domain of unknown function (DUF955); Region: DUF955; cl01076
561007011665	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
561007011666	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
561007011667	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
561007011668	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007011669	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007011670	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
561007011671	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
561007011672	active site
561007011673	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
561007011674	active site
561007011675	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
561007011676	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
561007011677	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
561007011678	Predicted acetyltransferase [General function prediction only]; Region: COG3153
561007011679	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
561007011680	Coenzyme A binding pocket [chemical binding]; other site
561007011681	TniQ; Region: TniQ; pfam06527
561007011682	Helix-turn-helix domains; Region: HTH; cl00088
561007011683	AAA domain; Region: AAA_22; pfam13401
561007011684	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
561007011685	Helix-turn-helix domains; Region: HTH; cl00088
561007011686	Helix-turn-helix domains; Region: HTH; cl00088
561007011687	Integrase core domain; Region: rve; cl01316
561007011688	Integrase core domain; Region: rve_3; cl15866
561007011689	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370
561007011690	replicative DNA helicase; Region: DnaB; TIGR00665
561007011691	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
561007011692	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
561007011693	Walker A motif; other site
561007011694	ATP binding site [chemical binding]; other site
561007011695	Walker B motif; other site
561007011696	DNA binding loops [nucleotide binding]
561007011697	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
561007011698	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
561007011699	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
561007011700	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
561007011701	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
561007011702	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
561007011703	dimer interface [polypeptide binding]; other site
561007011704	ssDNA binding site [nucleotide binding]; other site
561007011705	tetramer (dimer of dimers) interface [polypeptide binding]; other site
561007011706	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
561007011707	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
561007011708	Transglycosylase; Region: Transgly; cl07896
561007011709	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
561007011710	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
561007011711	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
561007011712	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
561007011713	Helix-turn-helix domains; Region: HTH; cl00088
561007011714	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
561007011715	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
561007011716	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
561007011717	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
561007011718	Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173
561007011719	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
561007011720	putative active site [active]
561007011721	putative substrate binding site [chemical binding]; other site
561007011722	ATP binding site [chemical binding]; other site
561007011723	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
561007011724	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
561007011725	active site
561007011726	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007011727	Helix-turn-helix domains; Region: HTH; cl00088
561007011728	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
561007011729	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
561007011730	classical (c) SDRs; Region: SDR_c; cd05233
561007011731	NAD(P) binding site [chemical binding]; other site
561007011732	active site
561007011733	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007011734	PknH-like extracellular domain; Region: PknH_C; pfam14032
561007011735	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
561007011736	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
561007011737	E3 interaction surface; other site
561007011738	lipoyl attachment site [posttranslational modification]; other site
561007011739	e3 binding domain; Region: E3_binding; pfam02817
561007011740	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
561007011741	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
561007011742	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
561007011743	alpha subunit interface [polypeptide binding]; other site
561007011744	TPP binding site [chemical binding]; other site
561007011745	heterodimer interface [polypeptide binding]; other site
561007011746	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
561007011747	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
561007011748	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
561007011749	tetramer interface [polypeptide binding]; other site
561007011750	TPP-binding site [chemical binding]; other site
561007011751	heterodimer interface [polypeptide binding]; other site
561007011752	phosphorylation loop region [posttranslational modification]
561007011753	Helix-turn-helix domains; Region: HTH; cl00088
561007011754	AsnC family; Region: AsnC_trans_reg; pfam01037
561007011755	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
561007011756	Predicted membrane protein [Function unknown]; Region: COG2311
561007011757	Protein of unknown function (DUF418); Region: DUF418; cl12135
561007011758	classical (c) SDRs; Region: SDR_c; cd05233
561007011759	NAD(P) binding site [chemical binding]; other site
561007011760	active site
561007011761	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
561007011762	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
561007011763	HIGH motif; other site
561007011764	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
561007011765	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
561007011766	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
561007011767	active site
561007011768	KMSKS motif; other site
561007011769	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
561007011770	tRNA binding surface [nucleotide binding]; other site
561007011771	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
561007011772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
561007011773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
561007011774	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
561007011775	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
561007011776	H+ Antiporter protein; Region: 2A0121; TIGR00900
561007011777	TIGR03084 family protein; Region: TIGR03084
561007011778	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
561007011779	Wyosine base formation; Region: Wyosine_form; pfam08608
561007011780	acyltransferase PapA5; Provisional; Region: PRK09294
561007011781	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
561007011782	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
561007011783	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
561007011784	active site
561007011785	NTP binding site [chemical binding]; other site
561007011786	metal binding triad [ion binding]; metal-binding site
561007011787	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
561007011788	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
561007011789	Zn2+ binding site [ion binding]; other site
561007011790	Mg2+ binding site [ion binding]; other site
561007011791	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
561007011792	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
561007011793	active site
561007011794	Ap6A binding site [chemical binding]; other site
561007011795	nudix motif; other site
561007011796	metal binding site [ion binding]; metal-binding site
561007011797	MviN-like protein; Region: MVIN; pfam03023
561007011798	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
561007011799	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
561007011800	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
561007011801	DNA binding residues [nucleotide binding]
561007011802	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
561007011803	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
561007011804	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
561007011805	catalytic residues [active]
561007011806	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
561007011807	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
561007011808	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
561007011809	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
561007011810	active site
561007011811	metal binding site [ion binding]; metal-binding site
561007011812	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
561007011813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
561007011814	Helix-turn-helix domains; Region: HTH; cl00088
561007011815	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
561007011816	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
561007011817	ParB-like nuclease domain; Region: ParBc; cl02129
561007011818	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
561007011819	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007011820	P-loop; other site
561007011821	Magnesium ion binding site [ion binding]; other site
561007011822	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
561007011823	Magnesium ion binding site [ion binding]; other site
561007011824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
561007011825	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
561007011826	G-X-X-G motif; other site
561007011827	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
561007011828	RxxxH motif; other site
561007011829	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
561007011830	Ribonuclease P; Region: Ribonuclease_P; cl00457
561007011831	Ribosomal protein L34; Region: Ribosomal_L34; cl00370