-- dump date 20140619_153342 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1168287000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1168287000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287000003 Walker A motif; other site 1168287000004 ATP binding site [chemical binding]; other site 1168287000005 Walker B motif; other site 1168287000006 arginine finger; other site 1168287000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1168287000008 DnaA box-binding interface [nucleotide binding]; other site 1168287000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1168287000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1168287000011 putative DNA binding surface [nucleotide binding]; other site 1168287000012 dimer interface [polypeptide binding]; other site 1168287000013 beta-clamp/clamp loader binding surface; other site 1168287000014 beta-clamp/translesion DNA polymerase binding surface; other site 1168287000015 recombination protein F; Reviewed; Region: recF; PRK00064 1168287000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1168287000017 Walker A/P-loop; other site 1168287000018 ATP binding site [chemical binding]; other site 1168287000019 Q-loop/lid; other site 1168287000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287000021 ABC transporter signature motif; other site 1168287000022 Walker B; other site 1168287000023 D-loop; other site 1168287000024 H-loop/switch region; other site 1168287000025 hypothetical protein; Provisional; Region: PRK03195 1168287000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1168287000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287000028 Mg2+ binding site [ion binding]; other site 1168287000029 G-X-G motif; other site 1168287000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1168287000031 anchoring element; other site 1168287000032 dimer interface [polypeptide binding]; other site 1168287000033 ATP binding site [chemical binding]; other site 1168287000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1168287000035 active site 1168287000036 putative metal-binding site [ion binding]; other site 1168287000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1168287000038 DNA gyrase subunit A; Validated; Region: PRK05560 1168287000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1168287000040 CAP-like domain; other site 1168287000041 active site 1168287000042 primary dimer interface [polypeptide binding]; other site 1168287000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168287000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168287000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168287000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168287000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168287000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168287000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1168287000050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000052 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287000053 Cytochrome P450; Region: p450; cl12078 1168287000054 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1168287000055 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1168287000056 active site 1168287000057 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1168287000058 putative septation inhibitor protein; Reviewed; Region: PRK00159 1168287000059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1168287000060 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1168287000061 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1168287000062 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1168287000063 glutamine binding [chemical binding]; other site 1168287000064 catalytic triad [active] 1168287000065 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1168287000066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287000067 active site 1168287000068 ATP binding site [chemical binding]; other site 1168287000069 substrate binding site [chemical binding]; other site 1168287000070 activation loop (A-loop); other site 1168287000071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1168287000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168287000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168287000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168287000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168287000076 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287000077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287000078 active site 1168287000079 ATP binding site [chemical binding]; other site 1168287000080 substrate binding site [chemical binding]; other site 1168287000081 activation loop (A-loop); other site 1168287000082 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1168287000083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168287000084 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1168287000085 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1168287000086 active site 1168287000087 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287000088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287000089 phosphopeptide binding site; other site 1168287000090 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1168287000091 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287000092 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287000093 phosphopeptide binding site; other site 1168287000094 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287000095 DinB superfamily; Region: DinB_2; pfam12867 1168287000096 acyl carrier protein; Validated; Region: PRK05883 1168287000097 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1168287000098 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287000099 acyl-activating enzyme (AAE) consensus motif; other site 1168287000100 AMP binding site [chemical binding]; other site 1168287000101 active site 1168287000102 CoA binding site [chemical binding]; other site 1168287000103 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1168287000104 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1168287000105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287000106 Coenzyme A binding pocket [chemical binding]; other site 1168287000107 Pirin-related protein [General function prediction only]; Region: COG1741 1168287000108 Pirin; Region: Pirin; pfam02678 1168287000109 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1168287000110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287000111 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287000112 active site 1168287000113 Transcription factor WhiB; Region: Whib; pfam02467 1168287000114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287000115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287000116 non-specific DNA binding site [nucleotide binding]; other site 1168287000117 salt bridge; other site 1168287000118 sequence-specific DNA binding site [nucleotide binding]; other site 1168287000119 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168287000120 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168287000121 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1168287000122 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1168287000123 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1168287000124 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1168287000125 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1168287000126 TIGR03084 family protein; Region: TIGR03084 1168287000127 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1168287000128 Wyosine base formation; Region: Wyosine_form; pfam08608 1168287000129 H+ Antiporter protein; Region: 2A0121; TIGR00900 1168287000130 hypothetical protein; Validated; Region: PRK00228 1168287000131 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1168287000132 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1168287000133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287000134 active site 1168287000135 HIGH motif; other site 1168287000136 nucleotide binding site [chemical binding]; other site 1168287000137 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1168287000138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287000139 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287000140 active site 1168287000141 KMSKS motif; other site 1168287000142 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1168287000143 tRNA binding surface [nucleotide binding]; other site 1168287000144 short chain dehydrogenase; Provisional; Region: PRK08219 1168287000145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287000146 NAD(P) binding site [chemical binding]; other site 1168287000147 active site 1168287000148 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287000149 MarR family; Region: MarR; pfam01047 1168287000150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287000151 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1168287000152 Walker A/P-loop; other site 1168287000153 ATP binding site [chemical binding]; other site 1168287000154 Q-loop/lid; other site 1168287000155 ABC transporter signature motif; other site 1168287000156 Walker B; other site 1168287000157 D-loop; other site 1168287000158 H-loop/switch region; other site 1168287000159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168287000160 substrate binding pocket [chemical binding]; other site 1168287000161 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168287000162 membrane-bound complex binding site; other site 1168287000163 hinge residues; other site 1168287000164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287000165 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1168287000166 dimer interface [polypeptide binding]; other site 1168287000167 conserved gate region; other site 1168287000168 putative PBP binding loops; other site 1168287000169 ABC-ATPase subunit interface; other site 1168287000170 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1168287000171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287000172 DNA-binding site [nucleotide binding]; DNA binding site 1168287000173 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1168287000174 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287000175 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287000176 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1168287000177 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1168287000178 active site 1168287000179 FMN binding site [chemical binding]; other site 1168287000180 substrate binding site [chemical binding]; other site 1168287000181 putative catalytic residue [active] 1168287000182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287000183 NAD(P) binding site [chemical binding]; other site 1168287000184 active site 1168287000185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000187 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287000188 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168287000189 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1168287000190 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287000191 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287000192 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1168287000193 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1168287000194 Predicted transcriptional regulators [Transcription]; Region: COG1695 1168287000195 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1168287000196 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1168287000197 Transglycosylase; Region: Transgly; pfam00912 1168287000198 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1168287000199 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168287000200 Predicted integral membrane protein [Function unknown]; Region: COG5650 1168287000201 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1168287000202 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1168287000203 conserved cys residue [active] 1168287000204 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1168287000205 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1168287000206 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1168287000207 dimer interface [polypeptide binding]; other site 1168287000208 ssDNA binding site [nucleotide binding]; other site 1168287000209 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168287000210 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1168287000211 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1168287000212 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1168287000213 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1168287000214 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1168287000215 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1168287000216 Walker A motif; other site 1168287000217 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1168287000218 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1168287000219 Walker A motif; other site 1168287000220 ATP binding site [chemical binding]; other site 1168287000221 Walker B motif; other site 1168287000222 DNA binding loops [nucleotide binding] 1168287000223 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1168287000224 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1168287000225 protein-splicing catalytic site; other site 1168287000226 thioester formation/cholesterol transfer; other site 1168287000227 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1168287000228 protein-splicing catalytic site; other site 1168287000229 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1168287000230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000232 Transport protein; Region: actII; TIGR00833 1168287000233 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287000234 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168287000235 DNA-binding site [nucleotide binding]; DNA binding site 1168287000236 RNA-binding motif; other site 1168287000237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287000238 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287000239 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1168287000240 classical (c) SDRs; Region: SDR_c; cd05233 1168287000241 NAD(P) binding site [chemical binding]; other site 1168287000242 active site 1168287000243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287000244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287000245 NAD(P) binding site [chemical binding]; other site 1168287000246 active site 1168287000247 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287000248 Cytochrome P450; Region: p450; cl12078 1168287000249 short chain dehydrogenase; Provisional; Region: PRK08303 1168287000250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287000251 NAD(P) binding site [chemical binding]; other site 1168287000252 active site 1168287000253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000255 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1168287000256 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1168287000257 putative dimer interface [polypeptide binding]; other site 1168287000258 classical (c) SDRs; Region: SDR_c; cd05233 1168287000259 NAD(P) binding site [chemical binding]; other site 1168287000260 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287000261 active site 1168287000262 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168287000263 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287000264 Berberine and berberine like; Region: BBE; pfam08031 1168287000265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168287000266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168287000267 ligand binding site [chemical binding]; other site 1168287000268 flexible hinge region; other site 1168287000269 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1168287000270 putative switch regulator; other site 1168287000271 non-specific DNA interactions [nucleotide binding]; other site 1168287000272 DNA binding site [nucleotide binding] 1168287000273 sequence specific DNA binding site [nucleotide binding]; other site 1168287000274 putative cAMP binding site [chemical binding]; other site 1168287000275 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287000276 PGAP1-like protein; Region: PGAP1; pfam07819 1168287000277 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1168287000278 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1168287000279 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1168287000280 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168287000281 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1168287000282 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287000283 active site 1168287000284 Permease; Region: Permease; pfam02405 1168287000285 Permease; Region: Permease; pfam02405 1168287000286 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1168287000287 mce related protein; Region: MCE; pfam02470 1168287000288 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1168287000289 mce related protein; Region: MCE; pfam02470 1168287000290 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287000291 mce related protein; Region: MCE; pfam02470 1168287000292 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287000293 mce related protein; Region: MCE; pfam02470 1168287000294 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287000295 mce related protein; Region: MCE; pfam02470 1168287000296 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168287000297 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287000298 mce related protein; Region: MCE; pfam02470 1168287000299 Mannan-binding protein; Region: MVL; pfam12151 1168287000300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000304 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1168287000305 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1168287000306 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287000307 PPE family; Region: PPE; pfam00823 1168287000308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287000309 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287000310 S-adenosylmethionine binding site [chemical binding]; other site 1168287000311 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287000312 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287000313 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287000314 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1168287000315 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1168287000316 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1168287000317 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287000318 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287000319 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1168287000320 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1168287000321 putative ligand binding site [chemical binding]; other site 1168287000322 NAD binding site [chemical binding]; other site 1168287000323 catalytic site [active] 1168287000324 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1168287000325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1168287000326 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287000327 Cytochrome P450; Region: p450; cl12078 1168287000328 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1168287000329 metal ion-dependent adhesion site (MIDAS); other site 1168287000330 MoxR-like ATPases [General function prediction only]; Region: COG0714 1168287000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287000332 Walker A motif; other site 1168287000333 ATP binding site [chemical binding]; other site 1168287000334 Walker B motif; other site 1168287000335 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1168287000336 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1168287000337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000338 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287000339 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287000340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287000341 metabolite-proton symporter; Region: 2A0106; TIGR00883 1168287000342 putative substrate translocation pore; other site 1168287000343 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287000344 Fe binding site [ion binding]; other site 1168287000345 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287000346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287000347 S-adenosylmethionine binding site [chemical binding]; other site 1168287000348 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168287000349 active site 1168287000350 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1168287000351 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1168287000352 putative active site [active] 1168287000353 putative CoA binding site [chemical binding]; other site 1168287000354 nudix motif; other site 1168287000355 metal binding site [ion binding]; metal-binding site 1168287000356 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1168287000357 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1168287000358 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287000359 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287000360 Predicted transcriptional regulators [Transcription]; Region: COG1695 1168287000361 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1168287000362 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1168287000363 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287000364 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1168287000365 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287000366 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1168287000367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287000368 hypothetical protein; Provisional; Region: PRK01346 1168287000369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287000370 Coenzyme A binding pocket [chemical binding]; other site 1168287000371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287000372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287000373 active site 1168287000374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287000377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287000378 dimer interface [polypeptide binding]; other site 1168287000379 phosphorylation site [posttranslational modification] 1168287000380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287000381 ATP binding site [chemical binding]; other site 1168287000382 Mg2+ binding site [ion binding]; other site 1168287000383 G-X-G motif; other site 1168287000384 PPE family; Region: PPE; pfam00823 1168287000385 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1168287000386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1168287000387 EspG family; Region: ESX-1_EspG; pfam14011 1168287000388 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1168287000389 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1168287000390 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1168287000391 catalytic residues [active] 1168287000392 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1168287000393 catalytic residues [active] 1168287000394 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1168287000395 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1168287000396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287000397 Walker A motif; other site 1168287000398 ATP binding site [chemical binding]; other site 1168287000399 Walker B motif; other site 1168287000400 arginine finger; other site 1168287000401 Domain of unknown function (DUF385); Region: DUF385; cl04387 1168287000402 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1168287000403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287000404 NAD(P) binding site [chemical binding]; other site 1168287000405 active site 1168287000406 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1168287000407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287000408 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1168287000409 DNA binding residues [nucleotide binding] 1168287000410 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1168287000411 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1168287000412 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1168287000413 active site 1168287000414 dimer interface [polypeptide binding]; other site 1168287000415 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1168287000416 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1168287000417 active site 1168287000418 FMN binding site [chemical binding]; other site 1168287000419 substrate binding site [chemical binding]; other site 1168287000420 3Fe-4S cluster binding site [ion binding]; other site 1168287000421 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1168287000422 domain interface; other site 1168287000423 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1168287000424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287000425 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1168287000426 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287000427 hypothetical protein; Provisional; Region: PRK07945 1168287000428 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1168287000429 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1168287000430 active site 1168287000431 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1168287000432 DNA polymerase IV; Validated; Region: PRK03858 1168287000433 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1168287000434 active site 1168287000435 DNA binding site [nucleotide binding] 1168287000436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000438 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287000439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287000440 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1168287000441 CopC domain; Region: CopC; pfam04234 1168287000442 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1168287000443 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1168287000444 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1168287000445 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1168287000446 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1168287000447 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1168287000448 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1168287000449 putative active site [active] 1168287000450 catalytic site [active] 1168287000451 putative metal binding site [ion binding]; other site 1168287000452 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1168287000453 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1168287000454 prephenate dehydratase; Provisional; Region: PRK11898 1168287000455 Prephenate dehydratase; Region: PDT; pfam00800 1168287000456 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1168287000457 putative L-Phe binding site [chemical binding]; other site 1168287000458 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287000459 catalytic core [active] 1168287000460 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1168287000461 Septum formation; Region: Septum_form; pfam13845 1168287000462 Septum formation; Region: Septum_form; pfam13845 1168287000463 seryl-tRNA synthetase; Provisional; Region: PRK05431 1168287000464 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1168287000465 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1168287000466 dimer interface [polypeptide binding]; other site 1168287000467 active site 1168287000468 motif 1; other site 1168287000469 motif 2; other site 1168287000470 motif 3; other site 1168287000471 Cupin domain; Region: Cupin_2; cl17218 1168287000472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287000473 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1168287000474 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1168287000475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287000476 S-adenosylmethionine binding site [chemical binding]; other site 1168287000477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287000478 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1168287000479 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287000480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000481 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287000482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287000483 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1168287000484 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1168287000485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1168287000486 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1168287000487 iron-sulfur cluster [ion binding]; other site 1168287000488 [2Fe-2S] cluster binding site [ion binding]; other site 1168287000489 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287000490 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168287000491 putative acyl-acceptor binding pocket; other site 1168287000492 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287000493 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168287000494 putative acyl-acceptor binding pocket; other site 1168287000495 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287000496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168287000497 putative acyl-acceptor binding pocket; other site 1168287000498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287000499 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1168287000500 active site 1168287000501 motif I; other site 1168287000502 motif II; other site 1168287000503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287000504 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1168287000505 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1168287000506 amidase catalytic site [active] 1168287000507 Zn binding residues [ion binding]; other site 1168287000508 substrate binding site [chemical binding]; other site 1168287000509 LGFP repeat; Region: LGFP; pfam08310 1168287000510 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1168287000511 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287000512 UDP-galactopyranose mutase; Region: GLF; pfam03275 1168287000513 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168287000514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1168287000515 active site 1168287000516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168287000517 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1168287000518 Predicted esterase [General function prediction only]; Region: COG0627 1168287000519 Putative esterase; Region: Esterase; pfam00756 1168287000520 Cutinase; Region: Cutinase; pfam01083 1168287000521 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1168287000522 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1168287000523 acyl-activating enzyme (AAE) consensus motif; other site 1168287000524 active site 1168287000525 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287000526 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287000527 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1168287000528 active site 1168287000529 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168287000530 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287000531 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287000532 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1168287000533 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168287000534 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168287000535 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287000536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287000537 active site 1168287000538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287000539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168287000540 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1168287000541 ligand binding site [chemical binding]; other site 1168287000542 flexible hinge region; other site 1168287000543 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1168287000544 putative switch regulator; other site 1168287000545 non-specific DNA interactions [nucleotide binding]; other site 1168287000546 DNA binding site [nucleotide binding] 1168287000547 sequence specific DNA binding site [nucleotide binding]; other site 1168287000548 putative cAMP binding site [chemical binding]; other site 1168287000549 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287000550 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287000551 phosphopeptide binding site; other site 1168287000552 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1168287000553 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1168287000554 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1168287000555 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1168287000556 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1168287000557 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1168287000558 putative hydrophobic ligand binding site [chemical binding]; other site 1168287000559 CLM binding site; other site 1168287000560 L1 loop; other site 1168287000561 DNA binding site [nucleotide binding] 1168287000562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287000563 putative DNA binding site [nucleotide binding]; other site 1168287000564 putative Zn2+ binding site [ion binding]; other site 1168287000565 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1168287000566 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1168287000567 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1168287000568 short chain dehydrogenase; Provisional; Region: PRK07904 1168287000569 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168287000570 NAD(P) binding site [chemical binding]; other site 1168287000571 active site 1168287000572 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168287000573 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287000574 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1168287000575 Predicted membrane protein [Function unknown]; Region: COG2246 1168287000576 GtrA-like protein; Region: GtrA; pfam04138 1168287000577 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1168287000578 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1168287000579 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287000580 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287000581 active site 1168287000582 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1168287000583 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1168287000584 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168287000585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168287000586 active site 1168287000587 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1168287000588 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1168287000589 Walker A/P-loop; other site 1168287000590 ATP binding site [chemical binding]; other site 1168287000591 Q-loop/lid; other site 1168287000592 ABC transporter signature motif; other site 1168287000593 Walker B; other site 1168287000594 D-loop; other site 1168287000595 H-loop/switch region; other site 1168287000596 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1168287000597 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1168287000598 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287000599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287000600 catalytic residue [active] 1168287000601 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1168287000602 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1168287000603 NAD(P) binding site [chemical binding]; other site 1168287000604 eRF1 domain 3; Region: eRF1_3; pfam03465 1168287000605 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287000606 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287000607 enoyl-CoA hydratase; Provisional; Region: PRK06142 1168287000608 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287000609 substrate binding site [chemical binding]; other site 1168287000610 oxyanion hole (OAH) forming residues; other site 1168287000611 trimer interface [polypeptide binding]; other site 1168287000612 TIGR03086 family protein; Region: TIGR03086 1168287000613 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1168287000614 GXWXG protein; Region: GXWXG; pfam14231 1168287000615 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1168287000616 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1168287000617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287000618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287000619 homodimer interface [polypeptide binding]; other site 1168287000620 catalytic residue [active] 1168287000621 Helix-turn-helix domain; Region: HTH_28; pfam13518 1168287000622 Winged helix-turn helix; Region: HTH_29; pfam13551 1168287000623 Homeodomain-like domain; Region: HTH_32; pfam13565 1168287000624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1168287000625 Integrase core domain; Region: rve; pfam00665 1168287000626 Integrase core domain; Region: rve_3; pfam13683 1168287000627 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287000628 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287000629 putative active site [active] 1168287000630 putative substrate binding site [chemical binding]; other site 1168287000631 ATP binding site [chemical binding]; other site 1168287000632 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287000633 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287000634 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287000635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287000636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287000637 active site 1168287000638 phosphorylation site [posttranslational modification] 1168287000639 intermolecular recognition site; other site 1168287000640 dimerization interface [polypeptide binding]; other site 1168287000641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287000642 DNA binding site [nucleotide binding] 1168287000643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287000644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1168287000645 dimerization interface [polypeptide binding]; other site 1168287000646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287000647 dimer interface [polypeptide binding]; other site 1168287000648 phosphorylation site [posttranslational modification] 1168287000649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287000650 ATP binding site [chemical binding]; other site 1168287000651 Mg2+ binding site [ion binding]; other site 1168287000652 G-X-G motif; other site 1168287000653 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1168287000654 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168287000655 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1168287000656 NAD(P) binding site [chemical binding]; other site 1168287000657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000659 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287000660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287000661 active site 1168287000662 short chain dehydrogenase; Provisional; Region: PRK07035 1168287000663 classical (c) SDRs; Region: SDR_c; cd05233 1168287000664 NAD(P) binding site [chemical binding]; other site 1168287000665 active site 1168287000666 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287000667 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287000668 putative active site [active] 1168287000669 putative substrate binding site [chemical binding]; other site 1168287000670 ATP binding site [chemical binding]; other site 1168287000671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287000672 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287000673 catalytic core [active] 1168287000674 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287000675 putative active site [active] 1168287000676 putative substrate binding site [chemical binding]; other site 1168287000677 ATP binding site [chemical binding]; other site 1168287000678 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1168287000679 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1168287000680 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1168287000681 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1168287000682 Walker A/P-loop; other site 1168287000683 ATP binding site [chemical binding]; other site 1168287000684 Q-loop/lid; other site 1168287000685 ABC transporter signature motif; other site 1168287000686 Walker B; other site 1168287000687 D-loop; other site 1168287000688 H-loop/switch region; other site 1168287000689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1168287000690 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1168287000691 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1168287000692 prephenate dehydrogenase; Validated; Region: PRK06545 1168287000693 prephenate dehydrogenase; Validated; Region: PRK08507 1168287000694 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1168287000695 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1168287000696 nucleoside/Zn binding site; other site 1168287000697 dimer interface [polypeptide binding]; other site 1168287000698 catalytic motif [active] 1168287000699 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1168287000700 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1168287000701 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1168287000702 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1168287000703 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1168287000704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287000705 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287000706 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287000707 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1168287000708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287000709 DNA-binding site [nucleotide binding]; DNA binding site 1168287000710 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1168287000711 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1168287000712 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1168287000713 active site 1168287000714 non-prolyl cis peptide bond; other site 1168287000715 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287000716 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287000717 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1168287000718 pyruvate carboxylase; Reviewed; Region: PRK12999 1168287000719 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168287000720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287000721 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168287000722 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1168287000723 active site 1168287000724 catalytic residues [active] 1168287000725 metal binding site [ion binding]; metal-binding site 1168287000726 homodimer binding site [polypeptide binding]; other site 1168287000727 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168287000728 carboxyltransferase (CT) interaction site; other site 1168287000729 biotinylation site [posttranslational modification]; other site 1168287000730 citrate synthase; Provisional; Region: PRK14033 1168287000731 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1168287000732 dimer interface [polypeptide binding]; other site 1168287000733 active site 1168287000734 citrylCoA binding site [chemical binding]; other site 1168287000735 oxalacetate/citrate binding site [chemical binding]; other site 1168287000736 coenzyme A binding site [chemical binding]; other site 1168287000737 catalytic triad [active] 1168287000738 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1168287000739 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1168287000740 tetramer interface [polypeptide binding]; other site 1168287000741 active site 1168287000742 Mg2+/Mn2+ binding site [ion binding]; other site 1168287000743 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1168287000744 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287000745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287000746 non-specific DNA binding site [nucleotide binding]; other site 1168287000747 salt bridge; other site 1168287000748 sequence-specific DNA binding site [nucleotide binding]; other site 1168287000749 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1168287000750 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1168287000751 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1168287000752 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1168287000753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168287000754 substrate binding site [chemical binding]; other site 1168287000755 ATP binding site [chemical binding]; other site 1168287000756 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1168287000757 dimerization interface [polypeptide binding]; other site 1168287000758 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1168287000759 NAD binding site [chemical binding]; other site 1168287000760 ligand binding site [chemical binding]; other site 1168287000761 catalytic site [active] 1168287000762 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287000763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000764 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287000765 classical (c) SDRs; Region: SDR_c; cd05233 1168287000766 NAD(P) binding site [chemical binding]; other site 1168287000767 active site 1168287000768 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168287000769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287000770 active site 1168287000771 metal binding site [ion binding]; metal-binding site 1168287000772 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287000773 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287000774 short chain dehydrogenase; Provisional; Region: PRK07856 1168287000775 classical (c) SDRs; Region: SDR_c; cd05233 1168287000776 NAD(P) binding site [chemical binding]; other site 1168287000777 active site 1168287000778 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287000779 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287000780 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 1168287000781 nudix motif; other site 1168287000782 haloalkane dehalogenase; Provisional; Region: PRK00870 1168287000783 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287000784 Cytochrome P450; Region: p450; cl12078 1168287000785 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287000786 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287000787 MULE transposase domain; Region: MULE; pfam10551 1168287000788 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1168287000789 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1168287000790 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1168287000791 active site 1168287000792 DNA binding site [nucleotide binding] 1168287000793 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1168287000794 DNA binding site [nucleotide binding] 1168287000795 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1168287000796 nucleotide binding site [chemical binding]; other site 1168287000797 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1168287000798 Isochorismatase family; Region: Isochorismatase; pfam00857 1168287000799 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1168287000800 catalytic triad [active] 1168287000801 conserved cis-peptide bond; other site 1168287000802 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287000803 Cytochrome P450; Region: p450; cl12078 1168287000804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287000805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287000806 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1168287000807 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1168287000808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287000809 NAD(P) binding site [chemical binding]; other site 1168287000810 active site 1168287000811 Cutinase; Region: Cutinase; pfam01083 1168287000812 CsbD-like; Region: CsbD; pfam05532 1168287000813 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287000814 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287000815 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287000816 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287000817 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1168287000818 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287000819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287000820 catalytic residue [active] 1168287000821 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1168287000822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287000823 Walker A motif; other site 1168287000824 ATP binding site [chemical binding]; other site 1168287000825 Walker B motif; other site 1168287000826 arginine finger; other site 1168287000827 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1168287000828 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287000829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287000830 S-adenosylmethionine binding site [chemical binding]; other site 1168287000831 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168287000832 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287000833 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1168287000834 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1168287000835 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1168287000836 active site 1168287000837 metal binding site [ion binding]; metal-binding site 1168287000838 hypothetical protein; Validated; Region: PRK00153 1168287000839 recombination protein RecR; Reviewed; Region: recR; PRK00076 1168287000840 RecR protein; Region: RecR; pfam02132 1168287000841 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1168287000842 putative active site [active] 1168287000843 putative metal-binding site [ion binding]; other site 1168287000844 tetramer interface [polypeptide binding]; other site 1168287000845 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1168287000846 catalytic triad [active] 1168287000847 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1168287000848 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168287000849 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1168287000850 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1168287000851 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1168287000852 active site 1168287000853 catalytic site [active] 1168287000854 substrate binding site [chemical binding]; other site 1168287000855 2-isopropylmalate synthase; Validated; Region: PRK03739 1168287000856 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1168287000857 active site 1168287000858 catalytic residues [active] 1168287000859 metal binding site [ion binding]; metal-binding site 1168287000860 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1168287000861 aspartate kinase; Reviewed; Region: PRK06635 1168287000862 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1168287000863 putative nucleotide binding site [chemical binding]; other site 1168287000864 putative catalytic residues [active] 1168287000865 putative Mg ion binding site [ion binding]; other site 1168287000866 putative aspartate binding site [chemical binding]; other site 1168287000867 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1168287000868 putative allosteric regulatory site; other site 1168287000869 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1168287000870 putative allosteric regulatory residue; other site 1168287000871 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1168287000872 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168287000873 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1168287000874 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287000875 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 1168287000876 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1168287000877 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1168287000878 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1168287000879 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1168287000880 putative active site [active] 1168287000881 putative dimer interface [polypeptide binding]; other site 1168287000882 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1168287000883 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1168287000884 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287000885 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1168287000886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287000887 catalytic residue [active] 1168287000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287000889 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287000890 S-adenosylmethionine binding site [chemical binding]; other site 1168287000891 glycerol kinase; Provisional; Region: glpK; PRK00047 1168287000892 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1168287000893 N- and C-terminal domain interface [polypeptide binding]; other site 1168287000894 active site 1168287000895 MgATP binding site [chemical binding]; other site 1168287000896 catalytic site [active] 1168287000897 metal binding site [ion binding]; metal-binding site 1168287000898 putative homotetramer interface [polypeptide binding]; other site 1168287000899 glycerol binding site [chemical binding]; other site 1168287000900 homodimer interface [polypeptide binding]; other site 1168287000901 Predicted transcriptional regulators [Transcription]; Region: COG1695 1168287000902 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1168287000903 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1168287000904 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1168287000905 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1168287000906 Protein of unknown function DUF58; Region: DUF58; pfam01882 1168287000907 MoxR-like ATPases [General function prediction only]; Region: COG0714 1168287000908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287000909 Walker A motif; other site 1168287000910 ATP binding site [chemical binding]; other site 1168287000911 Walker B motif; other site 1168287000912 arginine finger; other site 1168287000913 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1168287000914 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1168287000915 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1168287000916 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287000917 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1168287000918 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1168287000919 proposed catalytic triad [active] 1168287000920 conserved cys residue [active] 1168287000921 putative methyltransferase; Provisional; Region: PRK14967 1168287000922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287000923 S-adenosylmethionine binding site [chemical binding]; other site 1168287000924 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 1168287000925 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1168287000926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1168287000927 PAS domain; Region: PAS_9; pfam13426 1168287000928 putative active site [active] 1168287000929 heme pocket [chemical binding]; other site 1168287000930 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1168287000931 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1168287000932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1168287000933 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1168287000934 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1168287000935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287000936 ATP binding site [chemical binding]; other site 1168287000937 Mg2+ binding site [ion binding]; other site 1168287000938 G-X-G motif; other site 1168287000939 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1168287000940 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1168287000941 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1168287000942 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287000943 anti sigma factor interaction site; other site 1168287000944 regulatory phosphorylation site [posttranslational modification]; other site 1168287000945 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1168287000946 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1168287000947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287000948 motif II; other site 1168287000949 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1168287000950 Restriction endonuclease; Region: Mrr_cat; pfam04471 1168287000951 GAF domain; Region: GAF; cl17456 1168287000952 GAF domain; Region: GAF_2; pfam13185 1168287000953 ANTAR domain; Region: ANTAR; pfam03861 1168287000954 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168287000955 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1168287000956 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287000957 catalytic residue [active] 1168287000958 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1168287000959 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1168287000960 putative active site [active] 1168287000961 putative metal binding site [ion binding]; other site 1168287000962 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1168287000963 Transglycosylase; Region: Transgly; pfam00912 1168287000964 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1168287000965 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168287000966 Transcription factor WhiB; Region: Whib; pfam02467 1168287000967 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1168287000968 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1168287000969 DTAP/Switch II; other site 1168287000970 Switch I; other site 1168287000971 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1168287000972 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1168287000973 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1168287000974 P loop; other site 1168287000975 Nucleotide binding site [chemical binding]; other site 1168287000976 DTAP/Switch II; other site 1168287000977 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1168287000978 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1168287000979 homotrimer interaction site [polypeptide binding]; other site 1168287000980 putative active site [active] 1168287000981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287000982 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168287000983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168287000984 ligand binding site [chemical binding]; other site 1168287000985 flexible hinge region; other site 1168287000986 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1168287000987 putative switch regulator; other site 1168287000988 non-specific DNA interactions [nucleotide binding]; other site 1168287000989 DNA binding site [nucleotide binding] 1168287000990 sequence specific DNA binding site [nucleotide binding]; other site 1168287000991 putative cAMP binding site [chemical binding]; other site 1168287000992 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1168287000993 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168287000994 minor groove reading motif; other site 1168287000995 helix-hairpin-helix signature motif; other site 1168287000996 substrate binding pocket [chemical binding]; other site 1168287000997 active site 1168287000998 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1168287000999 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1168287001000 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168287001001 catalytic residues [active] 1168287001002 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1168287001003 putative active site [active] 1168287001004 putative CoA binding site [chemical binding]; other site 1168287001005 nudix motif; other site 1168287001006 metal binding site [ion binding]; metal-binding site 1168287001007 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1168287001008 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168287001009 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287001010 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1168287001011 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168287001012 acetyl-CoA synthetase; Provisional; Region: PRK00174 1168287001013 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1168287001014 active site 1168287001015 CoA binding site [chemical binding]; other site 1168287001016 acyl-activating enzyme (AAE) consensus motif; other site 1168287001017 AMP binding site [chemical binding]; other site 1168287001018 acetate binding site [chemical binding]; other site 1168287001019 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1168287001020 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1168287001021 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1168287001022 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168287001023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287001024 dimer interface [polypeptide binding]; other site 1168287001025 conserved gate region; other site 1168287001026 ABC-ATPase subunit interface; other site 1168287001027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168287001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287001029 dimer interface [polypeptide binding]; other site 1168287001030 conserved gate region; other site 1168287001031 putative PBP binding loops; other site 1168287001032 ABC-ATPase subunit interface; other site 1168287001033 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1168287001034 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168287001035 Walker A/P-loop; other site 1168287001036 ATP binding site [chemical binding]; other site 1168287001037 Q-loop/lid; other site 1168287001038 ABC transporter signature motif; other site 1168287001039 Walker B; other site 1168287001040 D-loop; other site 1168287001041 H-loop/switch region; other site 1168287001042 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168287001043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168287001044 Walker A/P-loop; other site 1168287001045 ATP binding site [chemical binding]; other site 1168287001046 Q-loop/lid; other site 1168287001047 ABC transporter signature motif; other site 1168287001048 Walker B; other site 1168287001049 D-loop; other site 1168287001050 H-loop/switch region; other site 1168287001051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168287001052 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1168287001053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287001054 motif II; other site 1168287001055 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1168287001056 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1168287001057 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1168287001058 hexamer interface [polypeptide binding]; other site 1168287001059 Walker B motif; other site 1168287001060 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1168287001061 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1168287001062 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1168287001063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287001064 ATP binding site [chemical binding]; other site 1168287001065 putative Mg++ binding site [ion binding]; other site 1168287001066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287001067 nucleotide binding region [chemical binding]; other site 1168287001068 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1168287001069 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168287001070 DNA-binding site [nucleotide binding]; DNA binding site 1168287001071 RNA-binding motif; other site 1168287001072 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1168287001073 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1168287001074 active site 1168287001075 interdomain interaction site; other site 1168287001076 putative metal-binding site [ion binding]; other site 1168287001077 nucleotide binding site [chemical binding]; other site 1168287001078 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1168287001079 domain I; other site 1168287001080 phosphate binding site [ion binding]; other site 1168287001081 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1168287001082 domain II; other site 1168287001083 domain III; other site 1168287001084 nucleotide binding site [chemical binding]; other site 1168287001085 DNA binding groove [nucleotide binding] 1168287001086 catalytic site [active] 1168287001087 domain IV; other site 1168287001088 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168287001089 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168287001090 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168287001091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168287001092 dimerization interface [polypeptide binding]; other site 1168287001093 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287001094 cyclase homology domain; Region: CHD; cd07302 1168287001095 nucleotidyl binding site; other site 1168287001096 metal binding site [ion binding]; metal-binding site 1168287001097 dimer interface [polypeptide binding]; other site 1168287001098 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1168287001099 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1168287001100 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287001101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001102 NAD(P) binding site [chemical binding]; other site 1168287001103 active site 1168287001104 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1168287001105 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1168287001106 Ligand binding site; other site 1168287001107 Putative Catalytic site; other site 1168287001108 DXD motif; other site 1168287001109 Protein of unknown function (DUF475); Region: DUF475; pfam04332 1168287001110 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1168287001111 dimer interface [polypeptide binding]; other site 1168287001112 substrate binding site [chemical binding]; other site 1168287001113 metal binding sites [ion binding]; metal-binding site 1168287001114 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1168287001115 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1168287001116 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1168287001117 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1168287001118 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1168287001119 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1168287001120 Ligand Binding Site [chemical binding]; other site 1168287001121 TilS substrate binding domain; Region: TilS; pfam09179 1168287001122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168287001123 active site 1168287001124 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1168287001125 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1168287001126 PE family; Region: PE; pfam00934 1168287001127 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287001128 PPE family; Region: PPE; pfam00823 1168287001129 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287001130 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287001131 active site 1168287001132 Integrase core domain; Region: rve; pfam00665 1168287001133 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287001134 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1168287001135 putative NAD(P) binding site [chemical binding]; other site 1168287001136 catalytic Zn binding site [ion binding]; other site 1168287001137 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287001138 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1168287001139 potential frameshift: common BLAST hit: gi|379752466|ref|YP_005341138.1| ephA 1168287001140 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287001141 active site 1168287001142 FtsH Extracellular; Region: FtsH_ext; pfam06480 1168287001143 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1168287001144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287001145 Walker A motif; other site 1168287001146 ATP binding site [chemical binding]; other site 1168287001147 Walker B motif; other site 1168287001148 arginine finger; other site 1168287001149 Peptidase family M41; Region: Peptidase_M41; pfam01434 1168287001150 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1168287001151 homodecamer interface [polypeptide binding]; other site 1168287001152 GTP cyclohydrolase I; Provisional; Region: PLN03044 1168287001153 active site 1168287001154 putative catalytic site residues [active] 1168287001155 zinc binding site [ion binding]; other site 1168287001156 GTP-CH-I/GFRP interaction surface; other site 1168287001157 dihydropteroate synthase; Region: DHPS; TIGR01496 1168287001158 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1168287001159 substrate binding pocket [chemical binding]; other site 1168287001160 dimer interface [polypeptide binding]; other site 1168287001161 inhibitor binding site; inhibition site 1168287001162 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1168287001163 active site 1168287001164 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1168287001165 catalytic center binding site [active] 1168287001166 ATP binding site [chemical binding]; other site 1168287001167 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1168287001168 Rossmann-like domain; Region: Rossmann-like; pfam10727 1168287001169 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1168287001170 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1168287001171 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1168287001172 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1168287001173 active site 1168287001174 ATP-binding site [chemical binding]; other site 1168287001175 pantoate-binding site; other site 1168287001176 HXXH motif; other site 1168287001177 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1168287001178 tetramerization interface [polypeptide binding]; other site 1168287001179 active site 1168287001180 pantothenate kinase; Reviewed; Region: PRK13318 1168287001181 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1168287001182 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1168287001183 dimer interface [polypeptide binding]; other site 1168287001184 putative anticodon binding site; other site 1168287001185 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168287001186 motif 1; other site 1168287001187 dimer interface [polypeptide binding]; other site 1168287001188 active site 1168287001189 motif 2; other site 1168287001190 motif 3; other site 1168287001191 Lsr2; Region: Lsr2; pfam11774 1168287001192 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1168287001193 Clp amino terminal domain; Region: Clp_N; pfam02861 1168287001194 Clp amino terminal domain; Region: Clp_N; pfam02861 1168287001195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287001196 Walker A motif; other site 1168287001197 ATP binding site [chemical binding]; other site 1168287001198 Walker B motif; other site 1168287001199 arginine finger; other site 1168287001200 UvrB/uvrC motif; Region: UVR; pfam02151 1168287001201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287001202 Walker A motif; other site 1168287001203 ATP binding site [chemical binding]; other site 1168287001204 Walker B motif; other site 1168287001205 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1168287001206 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1168287001207 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1168287001208 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1168287001209 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287001210 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168287001211 catalytic site [active] 1168287001212 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168287001213 minor groove reading motif; other site 1168287001214 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1168287001215 helix-hairpin-helix signature motif; other site 1168287001216 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1168287001217 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1168287001218 active site clefts [active] 1168287001219 zinc binding site [ion binding]; other site 1168287001220 dimer interface [polypeptide binding]; other site 1168287001221 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1168287001222 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1168287001223 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1168287001224 DNA repair protein RadA; Provisional; Region: PRK11823 1168287001225 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1168287001226 Walker A motif/ATP binding site; other site 1168287001227 ATP binding site [chemical binding]; other site 1168287001228 Walker B motif; other site 1168287001229 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1168287001230 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1168287001231 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1168287001232 substrate binding site; other site 1168287001233 dimer interface; other site 1168287001234 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1168287001235 homotrimer interaction site [polypeptide binding]; other site 1168287001236 zinc binding site [ion binding]; other site 1168287001237 CDP-binding sites; other site 1168287001238 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1168287001239 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287001240 active site 1168287001241 HIGH motif; other site 1168287001242 nucleotide binding site [chemical binding]; other site 1168287001243 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1168287001244 KMSKS motif; other site 1168287001245 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1168287001246 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168287001247 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1168287001248 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168287001249 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1168287001250 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1168287001251 active site 1168287001252 catalytic site [active] 1168287001253 metal binding site [ion binding]; metal-binding site 1168287001254 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1168287001255 transmembrane helices; other site 1168287001256 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1168287001257 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1168287001258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1168287001259 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1168287001260 putative active site [active] 1168287001261 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287001262 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1168287001263 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1168287001264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287001265 Walker A/P-loop; other site 1168287001266 ATP binding site [chemical binding]; other site 1168287001267 Q-loop/lid; other site 1168287001268 ABC transporter signature motif; other site 1168287001269 Walker B; other site 1168287001270 D-loop; other site 1168287001271 H-loop/switch region; other site 1168287001272 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168287001273 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1168287001274 intersubunit interface [polypeptide binding]; other site 1168287001275 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168287001276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168287001277 DNA binding site [nucleotide binding] 1168287001278 domain linker motif; other site 1168287001279 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1168287001280 putative dimerization interface [polypeptide binding]; other site 1168287001281 putative ligand binding site [chemical binding]; other site 1168287001282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001285 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287001286 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001287 active site 1168287001288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001290 active site 1168287001291 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287001292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001293 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1168287001294 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287001295 putative NAD(P) binding site [chemical binding]; other site 1168287001296 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1168287001297 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1168287001298 FAD binding pocket [chemical binding]; other site 1168287001299 FAD binding motif [chemical binding]; other site 1168287001300 phosphate binding motif [ion binding]; other site 1168287001301 beta-alpha-beta structure motif; other site 1168287001302 NAD(p) ribose binding residues [chemical binding]; other site 1168287001303 NAD binding pocket [chemical binding]; other site 1168287001304 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1168287001305 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287001306 catalytic loop [active] 1168287001307 iron binding site [ion binding]; other site 1168287001308 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001309 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1168287001310 Flavin binding site [chemical binding]; other site 1168287001311 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1168287001312 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1168287001313 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1168287001314 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1168287001315 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1168287001316 active site 1168287001317 Fe binding site [ion binding]; other site 1168287001318 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1168287001319 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1168287001320 aspartate aminotransferase; Provisional; Region: PRK05764 1168287001321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287001322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287001323 homodimer interface [polypeptide binding]; other site 1168287001324 catalytic residue [active] 1168287001325 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001326 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287001327 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001328 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1168287001329 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287001330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001331 active site 1168287001332 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001334 active site 1168287001335 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1168287001336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287001337 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1168287001338 acyl-activating enzyme (AAE) consensus motif; other site 1168287001339 acyl-activating enzyme (AAE) consensus motif; other site 1168287001340 putative AMP binding site [chemical binding]; other site 1168287001341 putative active site [active] 1168287001342 putative CoA binding site [chemical binding]; other site 1168287001343 CoA binding site [chemical binding]; other site 1168287001344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001346 active site 1168287001347 short chain dehydrogenase; Provisional; Region: PRK07831 1168287001348 classical (c) SDRs; Region: SDR_c; cd05233 1168287001349 NAD(P) binding site [chemical binding]; other site 1168287001350 active site 1168287001351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001353 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1168287001354 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1168287001355 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287001356 dimer interface [polypeptide binding]; other site 1168287001357 active site 1168287001358 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1168287001359 putative active site [active] 1168287001360 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1168287001361 Nitronate monooxygenase; Region: NMO; pfam03060 1168287001362 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287001363 FMN binding site [chemical binding]; other site 1168287001364 substrate binding site [chemical binding]; other site 1168287001365 putative catalytic residue [active] 1168287001366 Coenzyme A transferase; Region: CoA_trans; cl17247 1168287001367 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1168287001368 enoyl-CoA hydratase; Provisional; Region: PRK06495 1168287001369 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287001370 substrate binding site [chemical binding]; other site 1168287001371 oxyanion hole (OAH) forming residues; other site 1168287001372 trimer interface [polypeptide binding]; other site 1168287001373 short chain dehydrogenase; Provisional; Region: PRK07856 1168287001374 classical (c) SDRs; Region: SDR_c; cd05233 1168287001375 NAD(P) binding site [chemical binding]; other site 1168287001376 active site 1168287001377 short chain dehydrogenase; Provisional; Region: PRK07791 1168287001378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001379 NAD(P) binding site [chemical binding]; other site 1168287001380 active site 1168287001381 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287001382 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287001383 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1168287001384 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287001385 dimer interface [polypeptide binding]; other site 1168287001386 active site 1168287001387 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001388 Cytochrome P450; Region: p450; cl12078 1168287001389 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001390 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287001391 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001392 active site 1168287001393 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001395 active site 1168287001396 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1168287001397 active site 1168287001398 catalytic site [active] 1168287001399 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1168287001400 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287001401 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1168287001402 putative active site [active] 1168287001403 putative catalytic site [active] 1168287001404 lipid-transfer protein; Provisional; Region: PRK07855 1168287001405 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287001406 active site 1168287001407 enoyl-CoA hydratase; Region: PLN02864 1168287001408 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1168287001409 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1168287001410 dimer interaction site [polypeptide binding]; other site 1168287001411 substrate-binding tunnel; other site 1168287001412 active site 1168287001413 catalytic site [active] 1168287001414 substrate binding site [chemical binding]; other site 1168287001415 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1168287001416 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168287001417 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1168287001418 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1168287001419 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168287001420 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1168287001421 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1168287001422 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1168287001423 active site 1168287001424 catalytic residues [active] 1168287001425 metal binding site [ion binding]; metal-binding site 1168287001426 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1168287001427 short chain dehydrogenase; Provisional; Region: PRK07890 1168287001428 classical (c) SDRs; Region: SDR_c; cd05233 1168287001429 NAD(P) binding site [chemical binding]; other site 1168287001430 active site 1168287001431 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1168287001432 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1168287001433 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287001434 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1168287001435 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1168287001436 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1168287001437 trimer interface [polypeptide binding]; other site 1168287001438 putative metal binding site [ion binding]; other site 1168287001439 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287001440 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1168287001441 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287001442 active site 1168287001443 lipid-transfer protein; Provisional; Region: PRK07937 1168287001444 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287001445 active site 1168287001446 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1168287001447 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287001448 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1168287001449 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287001450 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287001451 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1168287001452 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1168287001453 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001454 Cytochrome P450; Region: p450; cl12078 1168287001455 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1168287001456 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1168287001457 putative active site [active] 1168287001458 enoyl-CoA hydratase; Provisional; Region: PRK07799 1168287001459 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287001460 substrate binding site [chemical binding]; other site 1168287001461 oxyanion hole (OAH) forming residues; other site 1168287001462 trimer interface [polypeptide binding]; other site 1168287001463 acyl-CoA synthetase; Validated; Region: PRK07798 1168287001464 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287001465 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1168287001466 acyl-activating enzyme (AAE) consensus motif; other site 1168287001467 acyl-activating enzyme (AAE) consensus motif; other site 1168287001468 putative AMP binding site [chemical binding]; other site 1168287001469 putative active site [active] 1168287001470 putative CoA binding site [chemical binding]; other site 1168287001471 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1168287001472 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287001473 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1168287001474 hypothetical protein; Validated; Region: PRK07586 1168287001475 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168287001476 PYR/PP interface [polypeptide binding]; other site 1168287001477 dimer interface [polypeptide binding]; other site 1168287001478 TPP binding site [chemical binding]; other site 1168287001479 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1168287001480 TPP-binding site [chemical binding]; other site 1168287001481 dimer interface [polypeptide binding]; other site 1168287001482 acyl-CoA synthetase; Validated; Region: PRK07867 1168287001483 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1168287001484 acyl-activating enzyme (AAE) consensus motif; other site 1168287001485 putative AMP binding site [chemical binding]; other site 1168287001486 putative active site [active] 1168287001487 putative CoA binding site [chemical binding]; other site 1168287001488 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001489 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287001490 active site 1168287001491 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001492 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1168287001493 FAD binding site [chemical binding]; other site 1168287001494 substrate binding site [chemical binding]; other site 1168287001495 catalytic base [active] 1168287001496 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1168287001497 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287001498 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1168287001499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001500 NAD(P) binding site [chemical binding]; other site 1168287001501 active site 1168287001502 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287001503 Permease; Region: Permease; pfam02405 1168287001504 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287001505 Permease; Region: Permease; pfam02405 1168287001506 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287001507 mce related protein; Region: MCE; pfam02470 1168287001508 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287001509 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287001510 mce related protein; Region: MCE; pfam02470 1168287001511 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287001512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287001513 mce related protein; Region: MCE; pfam02470 1168287001514 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1168287001515 mce related protein; Region: MCE; pfam02470 1168287001516 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287001517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287001518 mce related protein; Region: MCE; pfam02470 1168287001519 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287001520 mce related protein; Region: MCE; pfam02470 1168287001521 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1168287001522 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1168287001523 active site 1168287001524 homotetramer interface [polypeptide binding]; other site 1168287001525 enoyl-CoA hydratase; Provisional; Region: PRK08290 1168287001526 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287001527 substrate binding site [chemical binding]; other site 1168287001528 oxyanion hole (OAH) forming residues; other site 1168287001529 trimer interface [polypeptide binding]; other site 1168287001530 short chain dehydrogenase; Provisional; Region: PRK05875 1168287001531 classical (c) SDRs; Region: SDR_c; cd05233 1168287001532 NAD(P) binding site [chemical binding]; other site 1168287001533 active site 1168287001534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287001535 classical (c) SDRs; Region: SDR_c; cd05233 1168287001536 NAD(P) binding site [chemical binding]; other site 1168287001537 active site 1168287001538 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1168287001539 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168287001540 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1168287001541 Amidase; Region: Amidase; cl11426 1168287001542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287001543 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168287001544 Peptidase family S64; Region: Peptidase_S64; pfam08192 1168287001545 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1168287001546 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1168287001547 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1168287001548 catalytic residue [active] 1168287001549 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287001550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287001551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287001552 active site 1168287001553 phosphorylation site [posttranslational modification] 1168287001554 intermolecular recognition site; other site 1168287001555 dimerization interface [polypeptide binding]; other site 1168287001556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287001557 DNA binding site [nucleotide binding] 1168287001558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287001559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168287001560 dimerization interface [polypeptide binding]; other site 1168287001561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287001562 dimer interface [polypeptide binding]; other site 1168287001563 phosphorylation site [posttranslational modification] 1168287001564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287001565 ATP binding site [chemical binding]; other site 1168287001566 Mg2+ binding site [ion binding]; other site 1168287001567 G-X-G motif; other site 1168287001568 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1168287001569 nucleotide binding site/active site [active] 1168287001570 HIT family signature motif; other site 1168287001571 catalytic residue [active] 1168287001572 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1168287001573 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1168287001574 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1168287001575 NAD binding site [chemical binding]; other site 1168287001576 catalytic Zn binding site [ion binding]; other site 1168287001577 substrate binding site [chemical binding]; other site 1168287001578 structural Zn binding site [ion binding]; other site 1168287001579 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287001580 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1168287001581 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001582 Cytochrome P450; Region: p450; cl12078 1168287001583 short chain dehydrogenase; Provisional; Region: PRK07775 1168287001584 classical (c) SDRs; Region: SDR_c; cd05233 1168287001585 NAD(P) binding site [chemical binding]; other site 1168287001586 active site 1168287001587 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001588 Cytochrome P450; Region: p450; cl12078 1168287001589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001590 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1168287001591 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1168287001592 NAD binding site [chemical binding]; other site 1168287001593 catalytic residues [active] 1168287001594 short chain dehydrogenase; Provisional; Region: PRK07774 1168287001595 classical (c) SDRs; Region: SDR_c; cd05233 1168287001596 NAD(P) binding site [chemical binding]; other site 1168287001597 active site 1168287001598 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1168287001599 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168287001600 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1168287001601 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1168287001602 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1168287001603 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1168287001604 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1168287001605 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1168287001606 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1168287001607 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1168287001608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1168287001609 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1168287001610 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1168287001611 Lyase; Region: Lyase_1; pfam00206 1168287001612 tetramer interface [polypeptide binding]; other site 1168287001613 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001614 Cytochrome P450; Region: p450; cl12078 1168287001615 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1168287001616 gating phenylalanine in ion channel; other site 1168287001617 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1168287001618 ATP binding site [chemical binding]; other site 1168287001619 active site 1168287001620 substrate binding site [chemical binding]; other site 1168287001621 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1168287001622 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287001623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168287001624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287001625 putative substrate translocation pore; other site 1168287001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287001627 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1168287001628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287001629 putative substrate translocation pore; other site 1168287001630 Predicted deacetylase [General function prediction only]; Region: COG3233 1168287001631 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1168287001632 putative active site [active] 1168287001633 putative Zn binding site [ion binding]; other site 1168287001634 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168287001635 FAD binding domain; Region: FAD_binding_2; pfam00890 1168287001636 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1168287001637 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1168287001638 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1168287001639 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1168287001640 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1168287001641 putative active site [active] 1168287001642 catalytic triad [active] 1168287001643 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287001644 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287001645 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1168287001646 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1168287001647 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287001648 putative acyl-acceptor binding pocket; other site 1168287001649 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1168287001650 extended (e) SDRs; Region: SDR_e; cd08946 1168287001651 NAD(P) binding site [chemical binding]; other site 1168287001652 active site 1168287001653 substrate binding site [chemical binding]; other site 1168287001654 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1168287001655 Cupin domain; Region: Cupin_2; cl17218 1168287001656 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1168287001657 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287001658 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287001659 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1168287001660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287001661 motif II; other site 1168287001662 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1168287001663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1168287001664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287001665 Domain of unknown function (DUF427); Region: DUF427; cl00998 1168287001666 Domain of unknown function (DUF427); Region: DUF427; cl00998 1168287001667 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1168287001668 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168287001669 putative NAD(P) binding site [chemical binding]; other site 1168287001670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001673 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287001674 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287001675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1168287001676 MOSC domain; Region: MOSC; pfam03473 1168287001677 3-alpha domain; Region: 3-alpha; pfam03475 1168287001678 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1168287001679 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1168287001680 FAD binding pocket [chemical binding]; other site 1168287001681 FAD binding motif [chemical binding]; other site 1168287001682 phosphate binding motif [ion binding]; other site 1168287001683 beta-alpha-beta structure motif; other site 1168287001684 NAD binding pocket [chemical binding]; other site 1168287001685 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1168287001686 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1168287001687 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1168287001688 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1168287001689 active site 1168287001690 metal binding site [ion binding]; metal-binding site 1168287001691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001693 Ecdysteroid kinase; Region: EcKinase; cl17738 1168287001694 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287001695 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1168287001696 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1168287001697 dimerization interface [polypeptide binding]; other site 1168287001698 ATP binding site [chemical binding]; other site 1168287001699 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1168287001700 dimerization interface [polypeptide binding]; other site 1168287001701 ATP binding site [chemical binding]; other site 1168287001702 CAAX protease self-immunity; Region: Abi; pfam02517 1168287001703 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287001704 mce related protein; Region: MCE; pfam02470 1168287001705 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287001706 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1168287001707 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1168287001708 active site 1168287001709 tetramer interface [polypeptide binding]; other site 1168287001710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168287001711 active site 1168287001712 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1168287001713 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1168287001714 dimerization interface [polypeptide binding]; other site 1168287001715 putative ATP binding site [chemical binding]; other site 1168287001716 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1168287001717 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1168287001718 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1168287001719 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1168287001720 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1168287001721 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1168287001722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287001723 catalytic residue [active] 1168287001724 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1168287001725 heme-binding site [chemical binding]; other site 1168287001726 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1168287001727 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1168287001728 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1168287001729 active site residue [active] 1168287001730 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1168287001731 active site residue [active] 1168287001732 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1168287001733 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1168287001734 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168287001735 catalytic residues [active] 1168287001736 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1168287001737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287001738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287001739 DNA binding site [nucleotide binding] 1168287001740 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1168287001741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287001742 Coenzyme A binding pocket [chemical binding]; other site 1168287001743 PBP superfamily domain; Region: PBP_like_2; cl17296 1168287001744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287001745 dimer interface [polypeptide binding]; other site 1168287001746 conserved gate region; other site 1168287001747 putative PBP binding loops; other site 1168287001748 ABC-ATPase subunit interface; other site 1168287001749 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1168287001750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287001751 dimer interface [polypeptide binding]; other site 1168287001752 conserved gate region; other site 1168287001753 putative PBP binding loops; other site 1168287001754 ABC-ATPase subunit interface; other site 1168287001755 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1168287001756 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1168287001757 Walker A/P-loop; other site 1168287001758 ATP binding site [chemical binding]; other site 1168287001759 Q-loop/lid; other site 1168287001760 ABC transporter signature motif; other site 1168287001761 Walker B; other site 1168287001762 D-loop; other site 1168287001763 H-loop/switch region; other site 1168287001764 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1168287001765 PhoU domain; Region: PhoU; pfam01895 1168287001766 PhoU domain; Region: PhoU; pfam01895 1168287001767 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1168287001768 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168287001769 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1168287001770 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1168287001771 FMN binding site [chemical binding]; other site 1168287001772 active site 1168287001773 catalytic residues [active] 1168287001774 substrate binding site [chemical binding]; other site 1168287001775 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1168287001776 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1168287001777 homodimer interface [polypeptide binding]; other site 1168287001778 putative substrate binding pocket [chemical binding]; other site 1168287001779 diiron center [ion binding]; other site 1168287001780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1168287001782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287001783 dimerization interface [polypeptide binding]; other site 1168287001784 putative DNA binding site [nucleotide binding]; other site 1168287001785 putative Zn2+ binding site [ion binding]; other site 1168287001786 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1168287001787 nucleoside/Zn binding site; other site 1168287001788 dimer interface [polypeptide binding]; other site 1168287001789 catalytic motif [active] 1168287001790 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287001791 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287001792 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1168287001793 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168287001794 active site 1168287001795 DNA binding site [nucleotide binding] 1168287001796 Int/Topo IB signature motif; other site 1168287001797 Helix-turn-helix domain; Region: HTH_17; pfam12728 1168287001798 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287001799 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1168287001800 UTRA domain; Region: UTRA; pfam07702 1168287001801 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1168287001802 nudix motif; other site 1168287001803 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287001804 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287001805 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168287001806 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1168287001807 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1168287001808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001810 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001811 Cytochrome P450; Region: p450; cl12078 1168287001812 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1168287001813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001814 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287001815 classical (c) SDRs; Region: SDR_c; cd05233 1168287001816 NAD(P) binding site [chemical binding]; other site 1168287001817 active site 1168287001818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001820 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287001821 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1168287001822 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001823 Cytochrome P450; Region: p450; cl12078 1168287001824 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1168287001825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287001826 DNA-binding site [nucleotide binding]; DNA binding site 1168287001827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287001828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287001829 homodimer interface [polypeptide binding]; other site 1168287001830 catalytic residue [active] 1168287001831 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1168287001832 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287001833 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1168287001834 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287001835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287001836 S-adenosylmethionine binding site [chemical binding]; other site 1168287001837 short chain dehydrogenase; Provisional; Region: PRK08278 1168287001838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001839 NAD(P) binding site [chemical binding]; other site 1168287001840 active site 1168287001841 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1168287001842 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1168287001843 B12 binding site [chemical binding]; other site 1168287001844 cobalt ligand [ion binding]; other site 1168287001845 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1168287001846 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287001847 putative CoA-transferase; Provisional; Region: PRK11430 1168287001848 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287001849 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1168287001850 SnoaL-like domain; Region: SnoaL_3; pfam13474 1168287001851 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287001852 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287001853 catalytic loop [active] 1168287001854 iron binding site [ion binding]; other site 1168287001855 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1168287001856 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287001857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287001858 acyl-activating enzyme (AAE) consensus motif; other site 1168287001859 acyl-activating enzyme (AAE) consensus motif; other site 1168287001860 AMP binding site [chemical binding]; other site 1168287001861 active site 1168287001862 CoA binding site [chemical binding]; other site 1168287001863 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001864 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001866 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001867 active site 1168287001868 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287001869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287001870 substrate binding site [chemical binding]; other site 1168287001871 oxyanion hole (OAH) forming residues; other site 1168287001872 trimer interface [polypeptide binding]; other site 1168287001873 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1168287001874 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1168287001875 putative acyltransferase; Provisional; Region: PRK05790 1168287001876 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287001877 dimer interface [polypeptide binding]; other site 1168287001878 active site 1168287001879 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1168287001880 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1168287001881 Walker A; other site 1168287001882 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1168287001883 TPP-binding site [chemical binding]; other site 1168287001884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287001885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287001886 active site 1168287001887 phosphorylation site [posttranslational modification] 1168287001888 intermolecular recognition site; other site 1168287001889 dimerization interface [polypeptide binding]; other site 1168287001890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287001891 DNA binding residues [nucleotide binding] 1168287001892 dimerization interface [polypeptide binding]; other site 1168287001893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168287001894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287001895 ATP binding site [chemical binding]; other site 1168287001896 Mg2+ binding site [ion binding]; other site 1168287001897 G-X-G motif; other site 1168287001898 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1168287001899 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1168287001900 conserved cys residue [active] 1168287001901 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1168287001902 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1168287001903 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168287001904 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1168287001905 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287001906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287001907 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1168287001908 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287001909 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 1168287001910 active site 1168287001911 metal binding site [ion binding]; metal-binding site 1168287001912 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1168287001913 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1168287001914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287001915 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1168287001916 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1168287001917 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1168287001918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287001920 NAD(P) binding site [chemical binding]; other site 1168287001921 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1168287001922 active site 1168287001923 Putative cyclase; Region: Cyclase; pfam04199 1168287001924 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287001925 TAP-like protein; Region: Abhydrolase_4; pfam08386 1168287001926 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1168287001927 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1168287001928 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1168287001929 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1168287001930 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1168287001931 short chain dehydrogenase; Provisional; Region: PRK06500 1168287001932 classical (c) SDRs; Region: SDR_c; cd05233 1168287001933 NAD(P) binding site [chemical binding]; other site 1168287001934 active site 1168287001935 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1168287001936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001937 NAD(P) binding site [chemical binding]; other site 1168287001938 active site 1168287001939 AAA ATPase domain; Region: AAA_16; pfam13191 1168287001940 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287001941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287001942 DNA binding residues [nucleotide binding] 1168287001943 dimerization interface [polypeptide binding]; other site 1168287001944 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1168287001945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001946 NAD(P) binding site [chemical binding]; other site 1168287001947 active site 1168287001948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1168287001949 active site 1168287001950 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1168287001951 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1168287001952 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1168287001953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287001954 putative ADP-binding pocket [chemical binding]; other site 1168287001955 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1168287001956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001958 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287001959 Cytochrome P450; Region: p450; cl12078 1168287001960 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287001961 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287001962 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168287001963 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1168287001964 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1168287001965 active site 1168287001966 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168287001967 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1168287001968 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1168287001969 active site 1168287001970 enoyl-CoA hydratase; Provisional; Region: PRK12478 1168287001971 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287001972 substrate binding site [chemical binding]; other site 1168287001973 oxyanion hole (OAH) forming residues; other site 1168287001974 trimer interface [polypeptide binding]; other site 1168287001975 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287001976 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287001977 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287001978 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287001979 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1168287001980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287001981 NAD(P) binding site [chemical binding]; other site 1168287001982 active site 1168287001983 short chain dehydrogenase; Provisional; Region: PRK05876 1168287001984 classical (c) SDRs; Region: SDR_c; cd05233 1168287001985 NAD(P) binding site [chemical binding]; other site 1168287001986 active site 1168287001987 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287001988 classical (c) SDRs; Region: SDR_c; cd05233 1168287001989 NAD(P) binding site [chemical binding]; other site 1168287001990 active site 1168287001991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287001992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287001993 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001994 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001995 active site 1168287001996 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287001997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287001998 active site 1168287001999 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287002000 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287002001 active site 1168287002002 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287002003 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1168287002004 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1168287002005 active site 1168287002006 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287002007 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287002008 [2Fe-2S] cluster binding site [ion binding]; other site 1168287002009 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1168287002010 alpha subunit interface [polypeptide binding]; other site 1168287002011 active site 1168287002012 substrate binding site [chemical binding]; other site 1168287002013 Fe binding site [ion binding]; other site 1168287002014 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287002015 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287002016 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287002017 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287002018 active site 1168287002019 enoyl-CoA hydratase; Provisional; Region: PRK06688 1168287002020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002021 substrate binding site [chemical binding]; other site 1168287002022 oxyanion hole (OAH) forming residues; other site 1168287002023 trimer interface [polypeptide binding]; other site 1168287002024 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1168287002025 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287002026 dimer interface [polypeptide binding]; other site 1168287002027 active site 1168287002028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287002030 Cytochrome P450; Region: p450; cl12078 1168287002031 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1168287002032 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1168287002033 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287002034 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1168287002035 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287002036 Cytochrome P450; Region: p450; cl12078 1168287002037 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1168287002038 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168287002039 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168287002040 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1168287002041 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287002042 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287002043 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287002044 lipid-transfer protein; Provisional; Region: PRK07855 1168287002045 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287002046 active site 1168287002047 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287002048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287002049 NAD(P) binding site [chemical binding]; other site 1168287002050 active site 1168287002051 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1168287002052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287002053 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287002054 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287002055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287002056 active site 1168287002057 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1168287002058 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1168287002059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287002060 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1168287002061 iron-sulfur cluster [ion binding]; other site 1168287002062 [2Fe-2S] cluster binding site [ion binding]; other site 1168287002063 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287002064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287002065 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1168287002066 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168287002067 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1168287002068 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287002069 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1168287002070 NAD(P) binding site [chemical binding]; other site 1168287002071 catalytic residues [active] 1168287002072 catalytic residues [active] 1168287002073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002075 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1168287002076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002078 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 1168287002079 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1168287002080 putative catalytic cysteine [active] 1168287002081 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1168287002082 FMN binding site [chemical binding]; other site 1168287002083 dimer interface [polypeptide binding]; other site 1168287002084 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1168287002085 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287002086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287002087 active site 1168287002088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287002089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287002090 active site 1168287002091 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287002092 Cytochrome P450; Region: p450; cl12078 1168287002093 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1168287002094 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287002095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287002096 NAD(P) binding site [chemical binding]; other site 1168287002097 active site 1168287002098 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1168287002099 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1168287002100 NAD binding site [chemical binding]; other site 1168287002101 catalytic residues [active] 1168287002102 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287002103 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287002104 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287002105 Permease; Region: Permease; pfam02405 1168287002106 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287002107 Permease; Region: Permease; pfam02405 1168287002108 mce related protein; Region: MCE; pfam02470 1168287002109 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287002110 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287002111 mce related protein; Region: MCE; pfam02470 1168287002112 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287002113 mce related protein; Region: MCE; pfam02470 1168287002114 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287002115 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287002116 mce related protein; Region: MCE; pfam02470 1168287002117 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287002118 mce related protein; Region: MCE; pfam02470 1168287002119 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287002120 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287002121 mce related protein; Region: MCE; pfam02470 1168287002122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002124 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1168287002125 Subunit I/III interface [polypeptide binding]; other site 1168287002126 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287002127 Cytochrome P450; Region: p450; cl12078 1168287002128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002130 enoyl-CoA hydratase; Provisional; Region: PRK06688 1168287002131 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002132 substrate binding site [chemical binding]; other site 1168287002133 oxyanion hole (OAH) forming residues; other site 1168287002134 trimer interface [polypeptide binding]; other site 1168287002135 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1168287002136 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287002137 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1168287002138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287002139 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1168287002140 acyl-activating enzyme (AAE) consensus motif; other site 1168287002141 acyl-activating enzyme (AAE) consensus motif; other site 1168287002142 putative AMP binding site [chemical binding]; other site 1168287002143 putative active site [active] 1168287002144 putative CoA binding site [chemical binding]; other site 1168287002145 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1168287002146 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1168287002147 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1168287002148 dimer interface [polypeptide binding]; other site 1168287002149 PYR/PP interface [polypeptide binding]; other site 1168287002150 TPP binding site [chemical binding]; other site 1168287002151 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287002152 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1168287002153 TPP-binding site [chemical binding]; other site 1168287002154 dimer interface [polypeptide binding]; other site 1168287002155 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1168287002156 putative hydrophobic ligand binding site [chemical binding]; other site 1168287002157 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287002158 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287002159 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1168287002160 putative hydrophobic ligand binding site [chemical binding]; other site 1168287002161 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1168287002162 putative hydrophobic ligand binding site [chemical binding]; other site 1168287002163 aminotransferase; Validated; Region: PRK07777 1168287002164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287002165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287002166 homodimer interface [polypeptide binding]; other site 1168287002167 catalytic residue [active] 1168287002168 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1168287002169 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287002170 dimer interface [polypeptide binding]; other site 1168287002171 active site 1168287002172 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287002173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002174 substrate binding site [chemical binding]; other site 1168287002175 oxyanion hole (OAH) forming residues; other site 1168287002176 trimer interface [polypeptide binding]; other site 1168287002177 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1168287002178 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1168287002179 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1168287002180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287002181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287002182 S-adenosylmethionine binding site [chemical binding]; other site 1168287002183 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1168287002184 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1168287002185 hypothetical protein; Provisional; Region: PRK07588 1168287002186 hypothetical protein; Provisional; Region: PRK07236 1168287002187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002189 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287002190 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1168287002191 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1168287002192 Cupin; Region: Cupin_6; pfam12852 1168287002193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1168287002194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287002195 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1168287002196 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287002197 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287002198 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1168287002199 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287002200 active site 1168287002201 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1168287002202 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1168287002203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168287002204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287002205 ATP binding site [chemical binding]; other site 1168287002206 putative Mg++ binding site [ion binding]; other site 1168287002207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287002208 nucleotide binding region [chemical binding]; other site 1168287002209 ATP-binding site [chemical binding]; other site 1168287002210 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1168287002211 WYL domain; Region: WYL; pfam13280 1168287002212 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1168287002213 trimer interface [polypeptide binding]; other site 1168287002214 dimer interface [polypeptide binding]; other site 1168287002215 putative active site [active] 1168287002216 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1168287002217 MPT binding site; other site 1168287002218 trimer interface [polypeptide binding]; other site 1168287002219 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1168287002220 MoaE homodimer interface [polypeptide binding]; other site 1168287002221 MoaD interaction [polypeptide binding]; other site 1168287002222 active site residues [active] 1168287002223 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1168287002224 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1168287002225 MoaE interaction surface [polypeptide binding]; other site 1168287002226 MoeB interaction surface [polypeptide binding]; other site 1168287002227 thiocarboxylated glycine; other site 1168287002228 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1168287002229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287002230 FeS/SAM binding site; other site 1168287002231 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1168287002232 hypothetical protein; Provisional; Region: PRK11770 1168287002233 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1168287002234 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1168287002235 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168287002236 DNA-binding site [nucleotide binding]; DNA binding site 1168287002237 RNA-binding motif; other site 1168287002238 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287002239 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287002240 active site 1168287002241 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1168287002242 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1168287002243 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1168287002244 putative dimer interface [polypeptide binding]; other site 1168287002245 N-terminal domain interface [polypeptide binding]; other site 1168287002246 putative substrate binding pocket (H-site) [chemical binding]; other site 1168287002247 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1168287002248 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1168287002249 H+ Antiporter protein; Region: 2A0121; TIGR00900 1168287002250 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1168287002251 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287002252 hydrophobic ligand binding site; other site 1168287002253 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287002254 MarR family; Region: MarR; pfam01047 1168287002255 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168287002256 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168287002257 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1168287002258 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1168287002259 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287002260 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287002261 catalytic residue [active] 1168287002262 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1168287002263 Ferredoxin [Energy production and conversion]; Region: COG1146 1168287002264 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287002265 ferredoxin-NADP+ reductase; Region: PLN02852 1168287002266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287002267 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1168287002268 putative dimer interface [polypeptide binding]; other site 1168287002269 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287002270 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1168287002271 dimer interface [polypeptide binding]; other site 1168287002272 Citrate synthase; Region: Citrate_synt; pfam00285 1168287002273 active site 1168287002274 citrylCoA binding site [chemical binding]; other site 1168287002275 oxalacetate/citrate binding site [chemical binding]; other site 1168287002276 coenzyme A binding site [chemical binding]; other site 1168287002277 catalytic triad [active] 1168287002278 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1168287002279 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1168287002280 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1168287002281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1168287002282 active site 1168287002283 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1168287002284 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1168287002285 dimer interface [polypeptide binding]; other site 1168287002286 active site 1168287002287 citrylCoA binding site [chemical binding]; other site 1168287002288 NADH binding [chemical binding]; other site 1168287002289 cationic pore residues; other site 1168287002290 oxalacetate/citrate binding site [chemical binding]; other site 1168287002291 coenzyme A binding site [chemical binding]; other site 1168287002292 catalytic triad [active] 1168287002293 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287002294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287002295 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1168287002296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287002297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287002298 dimer interface [polypeptide binding]; other site 1168287002299 phosphorylation site [posttranslational modification] 1168287002300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287002301 ATP binding site [chemical binding]; other site 1168287002302 Mg2+ binding site [ion binding]; other site 1168287002303 G-X-G motif; other site 1168287002304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287002305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287002306 active site 1168287002307 phosphorylation site [posttranslational modification] 1168287002308 intermolecular recognition site; other site 1168287002309 dimerization interface [polypeptide binding]; other site 1168287002310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287002311 DNA binding site [nucleotide binding] 1168287002312 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1168287002313 putative active site [active] 1168287002314 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168287002315 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1168287002316 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287002317 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287002318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002319 substrate binding site [chemical binding]; other site 1168287002320 oxyanion hole (OAH) forming residues; other site 1168287002321 trimer interface [polypeptide binding]; other site 1168287002322 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1168287002323 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1168287002324 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287002325 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287002326 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1168287002327 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1168287002328 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287002329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287002330 motif II; other site 1168287002331 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1168287002332 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287002333 hydrophobic ligand binding site; other site 1168287002334 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1168287002335 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287002336 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1168287002337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287002338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287002339 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168287002340 active site 1168287002341 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1168287002342 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1168287002343 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1168287002344 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287002345 active site 1168287002346 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1168287002347 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287002348 PPE family; Region: PPE; pfam00823 1168287002349 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287002350 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287002351 PPE family; Region: PPE; pfam00823 1168287002352 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1168287002353 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287002354 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1168287002355 dimerization interface [polypeptide binding]; other site 1168287002356 putative catalytic residue [active] 1168287002357 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1168287002358 manganese transport protein MntH; Reviewed; Region: PRK00701 1168287002359 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1168287002360 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287002361 short chain dehydrogenase; Provisional; Region: PRK07814 1168287002362 classical (c) SDRs; Region: SDR_c; cd05233 1168287002363 NAD(P) binding site [chemical binding]; other site 1168287002364 active site 1168287002365 PBP superfamily domain; Region: PBP_like_2; cl17296 1168287002366 PBP superfamily domain; Region: PBP_like_2; cl17296 1168287002367 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1168287002368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287002369 dimer interface [polypeptide binding]; other site 1168287002370 conserved gate region; other site 1168287002371 putative PBP binding loops; other site 1168287002372 ABC-ATPase subunit interface; other site 1168287002373 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1168287002374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287002375 dimer interface [polypeptide binding]; other site 1168287002376 conserved gate region; other site 1168287002377 putative PBP binding loops; other site 1168287002378 ABC-ATPase subunit interface; other site 1168287002379 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1168287002380 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1168287002381 putative DNA binding site [nucleotide binding]; other site 1168287002382 putative homodimer interface [polypeptide binding]; other site 1168287002383 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287002384 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287002385 Integrase core domain; Region: rve; pfam00665 1168287002386 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1168287002387 ATP binding site [chemical binding]; other site 1168287002388 substrate binding site [chemical binding]; other site 1168287002389 Integrase core domain; Region: rve; pfam00665 1168287002390 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168287002391 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1168287002392 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1168287002393 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1168287002394 nucleotide binding site [chemical binding]; other site 1168287002395 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1168287002396 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1168287002397 active site 1168287002398 DNA binding site [nucleotide binding] 1168287002399 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1168287002400 DNA binding site [nucleotide binding] 1168287002401 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1168287002402 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1168287002403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287002404 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287002405 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287002406 enoyl-CoA hydratase; Provisional; Region: PRK08260 1168287002407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002408 substrate binding site [chemical binding]; other site 1168287002409 oxyanion hole (OAH) forming residues; other site 1168287002410 trimer interface [polypeptide binding]; other site 1168287002411 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287002412 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287002413 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287002414 anti sigma factor interaction site; other site 1168287002415 regulatory phosphorylation site [posttranslational modification]; other site 1168287002416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287002417 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287002418 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1168287002419 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1168287002420 active site 1168287002421 SAM binding site [chemical binding]; other site 1168287002422 homodimer interface [polypeptide binding]; other site 1168287002423 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1168287002424 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1168287002425 putative DNA binding site [nucleotide binding]; other site 1168287002426 catalytic residue [active] 1168287002427 putative H2TH interface [polypeptide binding]; other site 1168287002428 putative catalytic residues [active] 1168287002429 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168287002430 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1168287002431 short chain dehydrogenase; Provisional; Region: PRK08251 1168287002432 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1168287002433 putative NAD(P) binding site [chemical binding]; other site 1168287002434 active site 1168287002435 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1168287002436 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1168287002437 active site 1168287002438 dimer interface [polypeptide binding]; other site 1168287002439 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1168287002440 dimer interface [polypeptide binding]; other site 1168287002441 active site 1168287002442 Chorismate mutase type II; Region: CM_2; cl00693 1168287002443 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1168287002444 Part of AAA domain; Region: AAA_19; pfam13245 1168287002445 Family description; Region: UvrD_C_2; pfam13538 1168287002446 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1168287002447 Peptidase family M23; Region: Peptidase_M23; pfam01551 1168287002448 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1168287002449 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1168287002450 CoA-ligase; Region: Ligase_CoA; pfam00549 1168287002451 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1168287002452 CoA binding domain; Region: CoA_binding; smart00881 1168287002453 CoA-ligase; Region: Ligase_CoA; pfam00549 1168287002454 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1168287002455 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287002456 Omptin family; Region: Omptin; cl01886 1168287002457 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287002458 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287002459 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1168287002460 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1168287002461 active site 1168287002462 substrate binding site [chemical binding]; other site 1168287002463 cosubstrate binding site; other site 1168287002464 catalytic site [active] 1168287002465 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1168287002466 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1168287002467 purine monophosphate binding site [chemical binding]; other site 1168287002468 dimer interface [polypeptide binding]; other site 1168287002469 putative catalytic residues [active] 1168287002470 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1168287002471 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1168287002472 LGFP repeat; Region: LGFP; pfam08310 1168287002473 LGFP repeat; Region: LGFP; pfam08310 1168287002474 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1168287002475 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1168287002476 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1168287002477 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1168287002478 metal ion-dependent adhesion site (MIDAS); other site 1168287002479 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287002480 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287002481 active site 1168287002482 catalytic tetrad [active] 1168287002483 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1168287002484 enoyl-CoA hydratase; Provisional; Region: PRK07827 1168287002485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002486 substrate binding site [chemical binding]; other site 1168287002487 oxyanion hole (OAH) forming residues; other site 1168287002488 trimer interface [polypeptide binding]; other site 1168287002489 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287002490 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287002491 active site 1168287002492 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1168287002493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168287002494 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287002495 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168287002496 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168287002497 carboxyltransferase (CT) interaction site; other site 1168287002498 biotinylation site [posttranslational modification]; other site 1168287002499 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168287002500 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287002501 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287002502 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287002503 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287002504 active site 1168287002505 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1168287002506 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287002507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287002508 active site 1168287002509 phosphorylation site [posttranslational modification] 1168287002510 intermolecular recognition site; other site 1168287002511 dimerization interface [polypeptide binding]; other site 1168287002512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287002513 DNA binding site [nucleotide binding] 1168287002514 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1168287002515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168287002516 dimerization interface [polypeptide binding]; other site 1168287002517 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287002518 dimer interface [polypeptide binding]; other site 1168287002519 phosphorylation site [posttranslational modification] 1168287002520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287002521 ATP binding site [chemical binding]; other site 1168287002522 Mg2+ binding site [ion binding]; other site 1168287002523 G-X-G motif; other site 1168287002524 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1168287002525 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168287002526 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1168287002527 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1168287002528 MPT binding site; other site 1168287002529 trimer interface [polypeptide binding]; other site 1168287002530 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1168287002531 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1168287002532 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1168287002533 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1168287002534 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1168287002535 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1168287002536 active site 1168287002537 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1168287002538 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1168287002539 dimer interface [polypeptide binding]; other site 1168287002540 putative functional site; other site 1168287002541 putative MPT binding site; other site 1168287002542 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1168287002543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168287002544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168287002545 DNA binding site [nucleotide binding] 1168287002546 active site 1168287002547 Int/Topo IB signature motif; other site 1168287002548 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287002549 MULE transposase domain; Region: MULE; pfam10551 1168287002550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1168287002551 Homeodomain-like domain; Region: HTH_23; pfam13384 1168287002552 Integrase core domain; Region: rve; pfam00665 1168287002553 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1168287002554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287002555 Walker A motif; other site 1168287002556 ATP binding site [chemical binding]; other site 1168287002557 Walker B motif; other site 1168287002558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287002559 MarR family; Region: MarR_2; pfam12802 1168287002560 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1168287002561 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1168287002562 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287002563 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287002564 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1168287002565 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1168287002566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287002567 DNA-binding site [nucleotide binding]; DNA binding site 1168287002568 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1168287002569 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287002570 Cytochrome P450; Region: p450; cl12078 1168287002571 Predicted acyl esterases [General function prediction only]; Region: COG2936 1168287002572 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1168287002573 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1168287002574 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1168287002575 metal binding site [ion binding]; metal-binding site 1168287002576 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1168287002577 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1168287002578 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1168287002579 dimer interface [polypeptide binding]; other site 1168287002580 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1168287002581 active site 1168287002582 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1168287002583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287002584 active site 1168287002585 motif I; other site 1168287002586 motif II; other site 1168287002587 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168287002588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168287002589 ligand binding site [chemical binding]; other site 1168287002590 flexible hinge region; other site 1168287002591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1168287002592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287002593 Coenzyme A binding pocket [chemical binding]; other site 1168287002594 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1168287002595 Amidinotransferase; Region: Amidinotransf; cl12043 1168287002596 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1168287002597 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1168287002598 Predicted methyltransferases [General function prediction only]; Region: COG0313 1168287002599 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1168287002600 putative SAM binding site [chemical binding]; other site 1168287002601 putative homodimer interface [polypeptide binding]; other site 1168287002602 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1168287002603 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1168287002604 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1168287002605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287002606 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1168287002607 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1168287002608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287002609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287002610 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1168287002611 GAF domain; Region: GAF; pfam01590 1168287002612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1168287002613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1168287002614 metal binding site [ion binding]; metal-binding site 1168287002615 active site 1168287002616 I-site; other site 1168287002617 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1168287002618 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1168287002619 Chain length determinant protein; Region: Wzz; pfam02706 1168287002620 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1168287002621 O-Antigen ligase; Region: Wzy_C; cl04850 1168287002622 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287002623 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287002624 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287002625 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287002626 active site 1168287002627 catalytic tetrad [active] 1168287002628 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1168287002629 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1168287002630 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1168287002631 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1168287002632 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1168287002633 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1168287002634 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1168287002635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287002636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1168287002637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168287002638 active site 1168287002639 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168287002640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287002641 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287002642 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1168287002643 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1168287002644 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1168287002645 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1168287002646 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1168287002647 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287002648 PPE family; Region: PPE; pfam00823 1168287002649 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287002650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1168287002655 PAS domain; Region: PAS_9; pfam13426 1168287002656 putative active site [active] 1168287002657 heme pocket [chemical binding]; other site 1168287002658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002659 WHG domain; Region: WHG; pfam13305 1168287002660 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1168287002661 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1168287002662 active site 1168287002663 HIGH motif; other site 1168287002664 KMSKS motif; other site 1168287002665 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1168287002666 tRNA binding surface [nucleotide binding]; other site 1168287002667 anticodon binding site; other site 1168287002668 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1168287002669 active site 1168287002670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1168287002671 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1168287002672 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1168287002673 G5 domain; Region: G5; pfam07501 1168287002674 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1168287002675 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1168287002676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287002677 S-adenosylmethionine binding site [chemical binding]; other site 1168287002678 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1168287002679 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1168287002680 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287002681 acyl-activating enzyme (AAE) consensus motif; other site 1168287002682 AMP binding site [chemical binding]; other site 1168287002683 active site 1168287002684 CoA binding site [chemical binding]; other site 1168287002685 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1168287002686 putative active site [active] 1168287002687 catalytic residue [active] 1168287002688 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1168287002689 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1168287002690 5S rRNA interface [nucleotide binding]; other site 1168287002691 CTC domain interface [polypeptide binding]; other site 1168287002692 L16 interface [polypeptide binding]; other site 1168287002693 short chain dehydrogenase; Provisional; Region: PRK06197 1168287002694 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1168287002695 putative NAD(P) binding site [chemical binding]; other site 1168287002696 active site 1168287002697 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287002698 Cytochrome P450; Region: p450; cl12078 1168287002699 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287002700 cyclase homology domain; Region: CHD; cd07302 1168287002701 nucleotidyl binding site; other site 1168287002702 metal binding site [ion binding]; metal-binding site 1168287002703 dimer interface [polypeptide binding]; other site 1168287002704 Predicted ATPase [General function prediction only]; Region: COG3903 1168287002705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287002706 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287002707 DNA binding residues [nucleotide binding] 1168287002708 dimerization interface [polypeptide binding]; other site 1168287002709 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1168287002710 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1168287002711 ArsC family; Region: ArsC; pfam03960 1168287002712 catalytic residues [active] 1168287002713 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1168287002714 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1168287002715 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168287002716 active site 1168287002717 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1168287002718 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1168287002719 Substrate binding site; other site 1168287002720 Mg++ binding site; other site 1168287002721 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1168287002722 active site 1168287002723 substrate binding site [chemical binding]; other site 1168287002724 CoA binding site [chemical binding]; other site 1168287002725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002727 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1168287002728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1168287002729 active site 1168287002730 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168287002731 substrate binding site [chemical binding]; other site 1168287002732 catalytic residues [active] 1168287002733 dimer interface [polypeptide binding]; other site 1168287002734 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1168287002735 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1168287002736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287002737 ATP binding site [chemical binding]; other site 1168287002738 putative Mg++ binding site [ion binding]; other site 1168287002739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287002740 nucleotide binding region [chemical binding]; other site 1168287002741 ATP-binding site [chemical binding]; other site 1168287002742 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1168287002743 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1168287002744 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1168287002745 homodimer interface [polypeptide binding]; other site 1168287002746 metal binding site [ion binding]; metal-binding site 1168287002747 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1168287002748 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1168287002749 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1168287002750 enolase; Provisional; Region: eno; PRK00077 1168287002751 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1168287002752 dimer interface [polypeptide binding]; other site 1168287002753 metal binding site [ion binding]; metal-binding site 1168287002754 substrate binding pocket [chemical binding]; other site 1168287002755 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1168287002756 Septum formation initiator; Region: DivIC; pfam04977 1168287002757 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1168287002758 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1168287002759 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1168287002760 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1168287002761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287002762 active site 1168287002763 phosphorylation site [posttranslational modification] 1168287002764 intermolecular recognition site; other site 1168287002765 dimerization interface [polypeptide binding]; other site 1168287002766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287002767 DNA binding site [nucleotide binding] 1168287002768 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1168287002769 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1168287002770 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1168287002771 Ligand Binding Site [chemical binding]; other site 1168287002772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287002773 dimer interface [polypeptide binding]; other site 1168287002774 phosphorylation site [posttranslational modification] 1168287002775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287002776 ATP binding site [chemical binding]; other site 1168287002777 Mg2+ binding site [ion binding]; other site 1168287002778 G-X-G motif; other site 1168287002779 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1168287002780 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1168287002781 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1168287002782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287002783 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1168287002784 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1168287002785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287002786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287002787 dimer interface [polypeptide binding]; other site 1168287002788 phosphorylation site [posttranslational modification] 1168287002789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287002790 ATP binding site [chemical binding]; other site 1168287002791 Mg2+ binding site [ion binding]; other site 1168287002792 G-X-G motif; other site 1168287002793 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287002794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287002795 active site 1168287002796 phosphorylation site [posttranslational modification] 1168287002797 intermolecular recognition site; other site 1168287002798 dimerization interface [polypeptide binding]; other site 1168287002799 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287002800 DNA binding site [nucleotide binding] 1168287002801 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1168287002802 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1168287002803 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287002804 PPE family; Region: PPE; pfam00823 1168287002805 PE family; Region: PE; pfam00934 1168287002806 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287002807 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287002808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287002809 S-adenosylmethionine binding site [chemical binding]; other site 1168287002810 Domain of unknown function (DUF427); Region: DUF427; cl00998 1168287002811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1168287002812 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1168287002813 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1168287002814 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1168287002815 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1168287002816 dimer interface [polypeptide binding]; other site 1168287002817 acyl-activating enzyme (AAE) consensus motif; other site 1168287002818 putative active site [active] 1168287002819 AMP binding site [chemical binding]; other site 1168287002820 putative CoA binding site [chemical binding]; other site 1168287002821 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1168287002822 putative hydrophobic ligand binding site [chemical binding]; other site 1168287002823 protein interface [polypeptide binding]; other site 1168287002824 gate; other site 1168287002825 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1168287002826 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1168287002827 putative active site [active] 1168287002828 putative dimer interface [polypeptide binding]; other site 1168287002829 Patatin-like phospholipase; Region: Patatin; pfam01734 1168287002830 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1168287002831 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1168287002832 active site 1168287002833 nucleophile elbow; other site 1168287002834 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1168287002835 Rhodanese Homology Domain; Region: RHOD; smart00450 1168287002836 active site residue [active] 1168287002837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287002838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287002839 Predicted membrane protein [Function unknown]; Region: COG4425 1168287002840 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1168287002841 enoyl-CoA hydratase; Provisional; Region: PRK05862 1168287002842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002843 substrate binding site [chemical binding]; other site 1168287002844 oxyanion hole (OAH) forming residues; other site 1168287002845 trimer interface [polypeptide binding]; other site 1168287002846 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1168287002847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287002848 substrate binding site [chemical binding]; other site 1168287002849 oxyanion hole (OAH) forming residues; other site 1168287002850 trimer interface [polypeptide binding]; other site 1168287002851 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1168287002852 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1168287002853 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1168287002854 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287002855 dimer interface [polypeptide binding]; other site 1168287002856 active site 1168287002857 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1168287002858 active site 1168287002859 catalytic triad [active] 1168287002860 oxyanion hole [active] 1168287002861 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287002862 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287002863 substrate binding pocket [chemical binding]; other site 1168287002864 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1168287002865 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168287002866 dimer interface [polypeptide binding]; other site 1168287002867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287002868 catalytic residue [active] 1168287002869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1168287002870 RDD family; Region: RDD; pfam06271 1168287002871 cystathionine gamma-synthase; Provisional; Region: PRK07811 1168287002872 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168287002873 homodimer interface [polypeptide binding]; other site 1168287002874 substrate-cofactor binding pocket; other site 1168287002875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287002876 catalytic residue [active] 1168287002877 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1168287002878 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1168287002879 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1168287002880 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1168287002881 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1168287002882 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1168287002883 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1168287002884 catalytic residues [active] 1168287002885 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1168287002886 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287002887 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1168287002888 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1168287002889 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1168287002890 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1168287002891 catalytic residue [active] 1168287002892 putative FPP diphosphate binding site; other site 1168287002893 putative FPP binding hydrophobic cleft; other site 1168287002894 dimer interface [polypeptide binding]; other site 1168287002895 putative IPP diphosphate binding site; other site 1168287002896 pantothenate kinase; Provisional; Region: PRK05439 1168287002897 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1168287002898 ATP-binding site [chemical binding]; other site 1168287002899 CoA-binding site [chemical binding]; other site 1168287002900 Mg2+-binding site [ion binding]; other site 1168287002901 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1168287002902 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1168287002903 dimer interface [polypeptide binding]; other site 1168287002904 active site 1168287002905 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1168287002906 folate binding site [chemical binding]; other site 1168287002907 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1168287002908 dinuclear metal binding motif [ion binding]; other site 1168287002909 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1168287002910 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1168287002911 putative active site [active] 1168287002912 PhoH-like protein; Region: PhoH; pfam02562 1168287002913 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1168287002914 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1168287002915 NodB motif; other site 1168287002916 active site 1168287002917 catalytic site [active] 1168287002918 metal binding site [ion binding]; metal-binding site 1168287002919 HAMP domain; Region: HAMP; pfam00672 1168287002920 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1168287002921 cyclase homology domain; Region: CHD; cd07302 1168287002922 nucleotidyl binding site; other site 1168287002923 metal binding site [ion binding]; metal-binding site 1168287002924 dimer interface [polypeptide binding]; other site 1168287002925 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1168287002926 Class II fumarases; Region: Fumarase_classII; cd01362 1168287002927 active site 1168287002928 tetramer interface [polypeptide binding]; other site 1168287002929 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1168287002930 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1168287002931 putative active site [active] 1168287002932 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1168287002933 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1168287002934 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1168287002935 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1168287002936 homodimer interface [polypeptide binding]; other site 1168287002937 active site 1168287002938 TDP-binding site; other site 1168287002939 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287002940 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287002941 acyl-activating enzyme (AAE) consensus motif; other site 1168287002942 AMP binding site [chemical binding]; other site 1168287002943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287002944 Condensation domain; Region: Condensation; pfam00668 1168287002945 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287002946 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1168287002947 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287002948 substrate binding pocket [chemical binding]; other site 1168287002949 catalytic triad [active] 1168287002950 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1168287002951 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1168287002952 putative NAD(P) binding site [chemical binding]; other site 1168287002953 active site 1168287002954 putative substrate binding site [chemical binding]; other site 1168287002955 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1168287002956 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1168287002957 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1168287002958 generic binding surface II; other site 1168287002959 generic binding surface I; other site 1168287002960 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1168287002961 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1168287002962 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1168287002963 Membrane protein of unknown function; Region: DUF360; cl00850 1168287002964 GTP-binding protein YchF; Reviewed; Region: PRK09601 1168287002965 YchF GTPase; Region: YchF; cd01900 1168287002966 G1 box; other site 1168287002967 GTP/Mg2+ binding site [chemical binding]; other site 1168287002968 Switch I region; other site 1168287002969 G2 box; other site 1168287002970 Switch II region; other site 1168287002971 G3 box; other site 1168287002972 G4 box; other site 1168287002973 G5 box; other site 1168287002974 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1168287002975 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1168287002976 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1168287002977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1168287002978 putative dimer interface [polypeptide binding]; other site 1168287002979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287002980 ligand binding site [chemical binding]; other site 1168287002981 Zn binding site [ion binding]; other site 1168287002982 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287002983 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168287002984 active site 1168287002985 metal binding site [ion binding]; metal-binding site 1168287002986 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1168287002987 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287002988 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1168287002989 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287002990 cyclase homology domain; Region: CHD; cd07302 1168287002991 nucleotidyl binding site; other site 1168287002992 metal binding site [ion binding]; metal-binding site 1168287002993 dimer interface [polypeptide binding]; other site 1168287002994 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1168287002995 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1168287002996 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1168287002997 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1168287002998 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168287002999 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287003000 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287003001 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1168287003002 dimer interface [polypeptide binding]; other site 1168287003003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287003004 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287003005 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1168287003006 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1168287003007 Predicted membrane protein [Function unknown]; Region: COG2259 1168287003008 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1168287003009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287003010 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1168287003011 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1168287003012 TrkA-C domain; Region: TrkA_C; pfam02080 1168287003013 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1168287003014 TrkA-N domain; Region: TrkA_N; pfam02254 1168287003015 TrkA-C domain; Region: TrkA_C; pfam02080 1168287003016 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1168287003017 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287003018 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287003019 Integrase core domain; Region: rve; pfam00665 1168287003020 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1168287003021 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1168287003022 THF binding site; other site 1168287003023 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1168287003024 substrate binding site [chemical binding]; other site 1168287003025 THF binding site; other site 1168287003026 zinc-binding site [ion binding]; other site 1168287003027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003028 active site 1168287003029 short chain dehydrogenase; Provisional; Region: PRK12829 1168287003030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003031 NAD(P) binding site [chemical binding]; other site 1168287003032 active site 1168287003033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003037 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1168287003038 FMN binding site [chemical binding]; other site 1168287003039 dimer interface [polypeptide binding]; other site 1168287003040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003041 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287003042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003043 active site 1168287003044 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1168287003045 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003046 active site 1168287003047 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1168287003048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003049 short chain dehydrogenase; Provisional; Region: PRK07791 1168287003050 NAD(P) binding site [chemical binding]; other site 1168287003051 active site 1168287003052 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1168287003053 metal ion-dependent adhesion site (MIDAS); other site 1168287003054 MoxR-like ATPases [General function prediction only]; Region: COG0714 1168287003055 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1168287003056 Walker A motif; other site 1168287003057 ATP binding site [chemical binding]; other site 1168287003058 Walker B motif; other site 1168287003059 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1168287003060 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1168287003061 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1168287003062 ligand binding site [chemical binding]; other site 1168287003063 short chain dehydrogenase; Provisional; Region: PRK06179 1168287003064 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1168287003065 NADP binding site [chemical binding]; other site 1168287003066 active site 1168287003067 steroid binding site; other site 1168287003068 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287003069 Cytochrome P450; Region: p450; cl12078 1168287003070 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1168287003071 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1168287003072 NAD binding site [chemical binding]; other site 1168287003073 catalytic residues [active] 1168287003074 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1168287003075 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287003076 dimer interface [polypeptide binding]; other site 1168287003077 active site 1168287003078 enoyl-CoA hydratase; Provisional; Region: PRK08252 1168287003079 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287003080 substrate binding site [chemical binding]; other site 1168287003081 oxyanion hole (OAH) forming residues; other site 1168287003082 trimer interface [polypeptide binding]; other site 1168287003083 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1168287003084 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287003085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1168287003086 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1168287003087 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1168287003088 malonyl-CoA binding site [chemical binding]; other site 1168287003089 dimer interface [polypeptide binding]; other site 1168287003090 active site 1168287003091 product binding site; other site 1168287003092 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1168287003093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003094 NAD(P) binding site [chemical binding]; other site 1168287003095 active site 1168287003096 CAAX protease self-immunity; Region: Abi; pfam02517 1168287003097 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1168287003098 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1168287003099 putative NAD(P) binding site [chemical binding]; other site 1168287003100 putative active site [active] 1168287003101 enoyl-CoA hydratase; Provisional; Region: PRK06688 1168287003102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287003103 substrate binding site [chemical binding]; other site 1168287003104 oxyanion hole (OAH) forming residues; other site 1168287003105 trimer interface [polypeptide binding]; other site 1168287003106 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287003107 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287003108 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1168287003109 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1168287003110 NAD binding site [chemical binding]; other site 1168287003111 homodimer interface [polypeptide binding]; other site 1168287003112 homotetramer interface [polypeptide binding]; other site 1168287003113 active site 1168287003114 MMPL family; Region: MMPL; pfam03176 1168287003115 MMPL family; Region: MMPL; pfam03176 1168287003116 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1168287003117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287003118 S-adenosylmethionine binding site [chemical binding]; other site 1168287003119 NAD-dependent deacetylase; Provisional; Region: PRK00481 1168287003120 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1168287003121 NAD+ binding site [chemical binding]; other site 1168287003122 substrate binding site [chemical binding]; other site 1168287003123 Zn binding site [ion binding]; other site 1168287003124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287003125 DNA-binding site [nucleotide binding]; DNA binding site 1168287003126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1168287003127 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1168287003128 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1168287003129 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1168287003130 minor groove reading motif; other site 1168287003131 mannosyltransferase; Provisional; Region: pimE; PRK13375 1168287003132 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1168287003133 aromatic arch; other site 1168287003134 DCoH dimer interaction site [polypeptide binding]; other site 1168287003135 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1168287003136 DCoH tetramer interaction site [polypeptide binding]; other site 1168287003137 substrate binding site [chemical binding]; other site 1168287003138 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1168287003139 active site 1168287003140 8-oxo-dGMP binding site [chemical binding]; other site 1168287003141 nudix motif; other site 1168287003142 metal binding site [ion binding]; metal-binding site 1168287003143 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1168287003144 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1168287003145 [4Fe-4S] binding site [ion binding]; other site 1168287003146 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287003147 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287003148 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287003149 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1168287003150 molybdopterin cofactor binding site; other site 1168287003151 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1168287003152 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1168287003153 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1168287003154 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1168287003155 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1168287003156 G1 box; other site 1168287003157 putative GEF interaction site [polypeptide binding]; other site 1168287003158 GTP/Mg2+ binding site [chemical binding]; other site 1168287003159 Switch I region; other site 1168287003160 G2 box; other site 1168287003161 G3 box; other site 1168287003162 Switch II region; other site 1168287003163 G4 box; other site 1168287003164 G5 box; other site 1168287003165 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1168287003166 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1168287003167 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1168287003168 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1168287003169 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1168287003170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003172 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1168287003173 FO synthase; Reviewed; Region: fbiC; PRK09234 1168287003174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287003175 FeS/SAM binding site; other site 1168287003176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287003177 FeS/SAM binding site; other site 1168287003178 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1168287003179 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287003180 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1168287003181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287003182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287003183 homodimer interface [polypeptide binding]; other site 1168287003184 catalytic residue [active] 1168287003185 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1168287003186 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1168287003187 generic binding surface II; other site 1168287003188 ssDNA binding site; other site 1168287003189 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168287003190 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287003191 active site 1168287003192 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287003193 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1168287003194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003195 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1168287003196 Enoylreductase; Region: PKS_ER; smart00829 1168287003197 NAD(P) binding site [chemical binding]; other site 1168287003198 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1168287003199 KR domain; Region: KR; pfam08659 1168287003200 putative NADP binding site [chemical binding]; other site 1168287003201 active site 1168287003202 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287003203 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287003204 PPE family; Region: PPE; pfam00823 1168287003205 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287003206 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287003207 PPE family; Region: PPE; pfam00823 1168287003208 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287003209 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1168287003210 ligand-binding site [chemical binding]; other site 1168287003211 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1168287003212 ATP-sulfurylase; Region: ATPS; cd00517 1168287003213 active site 1168287003214 HXXH motif; other site 1168287003215 flexible loop; other site 1168287003216 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168287003217 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1168287003218 acyl-CoA synthetase; Validated; Region: PRK05850 1168287003219 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1168287003220 acyl-activating enzyme (AAE) consensus motif; other site 1168287003221 active site 1168287003222 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287003223 PPE family; Region: PPE; pfam00823 1168287003224 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1168287003225 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1168287003226 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287003227 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1168287003228 NAD(P) binding site [chemical binding]; other site 1168287003229 catalytic residues [active] 1168287003230 Proline dehydrogenase; Region: Pro_dh; cl03282 1168287003231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003233 lipid-transfer protein; Provisional; Region: PRK07855 1168287003234 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287003235 active site 1168287003236 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1168287003237 putative active site [active] 1168287003238 putative catalytic site [active] 1168287003239 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287003240 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287003241 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287003242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287003243 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1168287003244 NAD binding site [chemical binding]; other site 1168287003245 catalytic residues [active] 1168287003246 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287003247 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1168287003248 acyl-CoA synthetase; Validated; Region: PRK07787 1168287003249 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287003250 acyl-activating enzyme (AAE) consensus motif; other site 1168287003251 AMP binding site [chemical binding]; other site 1168287003252 active site 1168287003253 CoA binding site [chemical binding]; other site 1168287003254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287003255 metabolite-proton symporter; Region: 2A0106; TIGR00883 1168287003256 putative substrate translocation pore; other site 1168287003257 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1168287003258 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1168287003259 putative trimer interface [polypeptide binding]; other site 1168287003260 putative CoA binding site [chemical binding]; other site 1168287003261 PE family; Region: PE; pfam00934 1168287003262 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287003263 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287003264 PPE family; Region: PPE; pfam00823 1168287003265 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1168287003266 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1168287003267 metal binding site [ion binding]; metal-binding site 1168287003268 putative dimer interface [polypeptide binding]; other site 1168287003269 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1168287003270 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1168287003271 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1168287003272 acyl-activating enzyme (AAE) consensus motif; other site 1168287003273 putative AMP binding site [chemical binding]; other site 1168287003274 putative active site [active] 1168287003275 putative CoA binding site [chemical binding]; other site 1168287003276 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1168287003277 dihydropteroate synthase; Region: DHPS; TIGR01496 1168287003278 substrate binding pocket [chemical binding]; other site 1168287003279 dimer interface [polypeptide binding]; other site 1168287003280 inhibitor binding site; inhibition site 1168287003281 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1168287003282 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1168287003283 DivIVA domain; Region: DivI1A_domain; TIGR03544 1168287003284 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1168287003285 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1168287003286 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1168287003287 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287003288 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1168287003289 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1168287003290 ligand binding site; other site 1168287003291 oligomer interface; other site 1168287003292 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1168287003293 dimer interface [polypeptide binding]; other site 1168287003294 N-terminal domain interface [polypeptide binding]; other site 1168287003295 sulfate 1 binding site; other site 1168287003296 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1168287003297 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1168287003298 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1168287003299 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168287003300 Walker A/P-loop; other site 1168287003301 ATP binding site [chemical binding]; other site 1168287003302 Q-loop/lid; other site 1168287003303 ABC transporter signature motif; other site 1168287003304 Walker B; other site 1168287003305 D-loop; other site 1168287003306 H-loop/switch region; other site 1168287003307 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1168287003308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003310 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1168287003311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287003312 S-adenosylmethionine binding site [chemical binding]; other site 1168287003313 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1168287003314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287003315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287003316 DNA binding residues [nucleotide binding] 1168287003317 Putative zinc-finger; Region: zf-HC2; pfam13490 1168287003318 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1168287003319 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168287003320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1168287003321 protein binding site [polypeptide binding]; other site 1168287003322 sec-independent translocase; Provisional; Region: PRK03100 1168287003323 Domain of unknown function DUF59; Region: DUF59; cl00941 1168287003324 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1168287003325 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1168287003326 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1168287003327 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1168287003328 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1168287003329 catalytic residue [active] 1168287003330 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1168287003331 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1168287003332 MgtE intracellular N domain; Region: MgtE_N; smart00924 1168287003333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1168287003334 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1168287003335 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1168287003336 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168287003337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287003338 dimer interface [polypeptide binding]; other site 1168287003339 conserved gate region; other site 1168287003340 putative PBP binding loops; other site 1168287003341 ABC-ATPase subunit interface; other site 1168287003342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168287003343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287003344 dimer interface [polypeptide binding]; other site 1168287003345 conserved gate region; other site 1168287003346 ABC-ATPase subunit interface; other site 1168287003347 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1168287003348 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1168287003349 Walker A/P-loop; other site 1168287003350 ATP binding site [chemical binding]; other site 1168287003351 Q-loop/lid; other site 1168287003352 ABC transporter signature motif; other site 1168287003353 Walker B; other site 1168287003354 D-loop; other site 1168287003355 H-loop/switch region; other site 1168287003356 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1168287003357 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1168287003358 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1168287003359 putative active site [active] 1168287003360 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1168287003361 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1168287003362 oligomer interface [polypeptide binding]; other site 1168287003363 metal binding site [ion binding]; metal-binding site 1168287003364 metal binding site [ion binding]; metal-binding site 1168287003365 putative Cl binding site [ion binding]; other site 1168287003366 basic sphincter; other site 1168287003367 hydrophobic gate; other site 1168287003368 periplasmic entrance; other site 1168287003369 malate dehydrogenase; Provisional; Region: PRK05442 1168287003370 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1168287003371 NAD(P) binding site [chemical binding]; other site 1168287003372 dimer interface [polypeptide binding]; other site 1168287003373 malate binding site [chemical binding]; other site 1168287003374 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1168287003375 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1168287003376 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1168287003377 putative NAD(P) binding site [chemical binding]; other site 1168287003378 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1168287003379 short chain dehydrogenase; Provisional; Region: PRK07832 1168287003380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003381 NAD(P) binding site [chemical binding]; other site 1168287003382 active site 1168287003383 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1168287003384 classical (c) SDRs; Region: SDR_c; cd05233 1168287003385 NAD(P) binding site [chemical binding]; other site 1168287003386 active site 1168287003387 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1168287003388 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1168287003389 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1168287003390 TPP-binding site [chemical binding]; other site 1168287003391 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1168287003392 dimer interface [polypeptide binding]; other site 1168287003393 PYR/PP interface [polypeptide binding]; other site 1168287003394 TPP binding site [chemical binding]; other site 1168287003395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287003396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168287003397 putative substrate translocation pore; other site 1168287003398 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1168287003399 RNase_H superfamily; Region: RNase_H_2; pfam13482 1168287003400 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1168287003401 Part of AAA domain; Region: AAA_19; pfam13245 1168287003402 AAA domain; Region: AAA_12; pfam13087 1168287003403 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1168287003404 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1168287003405 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1168287003406 ATP binding site [chemical binding]; other site 1168287003407 Mg++ binding site [ion binding]; other site 1168287003408 motif III; other site 1168287003409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287003410 nucleotide binding region [chemical binding]; other site 1168287003411 ATP-binding site [chemical binding]; other site 1168287003412 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1168287003413 putative RNA binding site [nucleotide binding]; other site 1168287003414 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1168287003415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287003418 Cytochrome P450; Region: p450; cl12078 1168287003419 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287003420 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1168287003421 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1168287003422 Fe-S cluster binding site [ion binding]; other site 1168287003423 DNA binding site [nucleotide binding] 1168287003424 active site 1168287003425 hypothetical protein; Validated; Region: PRK05868 1168287003426 hypothetical protein; Provisional; Region: PRK07236 1168287003427 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1168287003428 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287003429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1168287003430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1168287003431 metal binding site [ion binding]; metal-binding site 1168287003432 active site 1168287003433 I-site; other site 1168287003434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1168287003435 metal binding site [ion binding]; metal-binding site 1168287003436 active site 1168287003437 I-site; other site 1168287003438 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1168287003439 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1168287003440 HIT family signature motif; other site 1168287003441 catalytic residue [active] 1168287003442 amidase; Provisional; Region: PRK12470 1168287003443 Amidase; Region: Amidase; pfam01425 1168287003444 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1168287003445 putative active site [active] 1168287003446 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287003447 cyclase homology domain; Region: CHD; cd07302 1168287003448 nucleotidyl binding site; other site 1168287003449 metal binding site [ion binding]; metal-binding site 1168287003450 dimer interface [polypeptide binding]; other site 1168287003451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287003452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287003453 active site 1168287003454 ATP binding site [chemical binding]; other site 1168287003455 substrate binding site [chemical binding]; other site 1168287003456 activation loop (A-loop); other site 1168287003457 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287003458 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168287003459 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168287003460 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1168287003461 Walker A/P-loop; other site 1168287003462 ATP binding site [chemical binding]; other site 1168287003463 Q-loop/lid; other site 1168287003464 ABC transporter signature motif; other site 1168287003465 Walker B; other site 1168287003466 D-loop; other site 1168287003467 H-loop/switch region; other site 1168287003468 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168287003469 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168287003470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287003471 Walker A/P-loop; other site 1168287003472 ATP binding site [chemical binding]; other site 1168287003473 Q-loop/lid; other site 1168287003474 ABC transporter signature motif; other site 1168287003475 Walker B; other site 1168287003476 D-loop; other site 1168287003477 H-loop/switch region; other site 1168287003478 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1168287003479 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1168287003480 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287003481 catalytic core [active] 1168287003482 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1168287003483 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1168287003484 active site 1168287003485 metal binding site [ion binding]; metal-binding site 1168287003486 DNA binding site [nucleotide binding] 1168287003487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287003488 Walker A/P-loop; other site 1168287003489 ATP binding site [chemical binding]; other site 1168287003490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287003491 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1168287003492 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1168287003493 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1168287003494 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168287003495 Walker A/P-loop; other site 1168287003496 ATP binding site [chemical binding]; other site 1168287003497 Q-loop/lid; other site 1168287003498 ABC transporter signature motif; other site 1168287003499 Walker B; other site 1168287003500 D-loop; other site 1168287003501 H-loop/switch region; other site 1168287003502 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168287003503 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168287003504 Walker A/P-loop; other site 1168287003505 ATP binding site [chemical binding]; other site 1168287003506 Q-loop/lid; other site 1168287003507 ABC transporter signature motif; other site 1168287003508 Walker B; other site 1168287003509 D-loop; other site 1168287003510 H-loop/switch region; other site 1168287003511 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168287003512 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168287003513 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1168287003514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287003515 dimer interface [polypeptide binding]; other site 1168287003516 conserved gate region; other site 1168287003517 putative PBP binding loops; other site 1168287003518 ABC-ATPase subunit interface; other site 1168287003519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168287003520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287003521 dimer interface [polypeptide binding]; other site 1168287003522 conserved gate region; other site 1168287003523 putative PBP binding loops; other site 1168287003524 ABC-ATPase subunit interface; other site 1168287003525 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1168287003526 active site clefts [active] 1168287003527 zinc binding site [ion binding]; other site 1168287003528 dimer interface [polypeptide binding]; other site 1168287003529 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287003530 CoenzymeA binding site [chemical binding]; other site 1168287003531 subunit interaction site [polypeptide binding]; other site 1168287003532 PHB binding site; other site 1168287003533 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1168287003534 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1168287003535 Active Sites [active] 1168287003536 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1168287003537 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1168287003538 CysD dimerization site [polypeptide binding]; other site 1168287003539 G1 box; other site 1168287003540 putative GEF interaction site [polypeptide binding]; other site 1168287003541 GTP/Mg2+ binding site [chemical binding]; other site 1168287003542 Switch I region; other site 1168287003543 G2 box; other site 1168287003544 G3 box; other site 1168287003545 Switch II region; other site 1168287003546 G4 box; other site 1168287003547 G5 box; other site 1168287003548 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1168287003549 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1168287003550 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1168287003551 ligand-binding site [chemical binding]; other site 1168287003552 Rrf2 family protein; Region: rrf2_super; TIGR00738 1168287003553 Transcriptional regulator; Region: Rrf2; pfam02082 1168287003554 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 1168287003555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287003556 metal binding site [ion binding]; metal-binding site 1168287003557 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1168287003558 putative dimer interface [polypeptide binding]; other site 1168287003559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287003560 ligand binding site [chemical binding]; other site 1168287003561 Zn binding site [ion binding]; other site 1168287003562 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287003563 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1168287003564 TrkA-N domain; Region: TrkA_N; pfam02254 1168287003565 Ion channel; Region: Ion_trans_2; pfam07885 1168287003566 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1168287003567 TrkA-N domain; Region: TrkA_N; pfam02254 1168287003568 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287003569 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1168287003570 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1168287003571 dimer interface [polypeptide binding]; other site 1168287003572 ADP-ribose binding site [chemical binding]; other site 1168287003573 active site 1168287003574 nudix motif; other site 1168287003575 metal binding site [ion binding]; metal-binding site 1168287003576 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1168287003577 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1168287003578 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1168287003579 active site 1168287003580 HIGH motif; other site 1168287003581 KMSK motif region; other site 1168287003582 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1168287003583 tRNA binding surface [nucleotide binding]; other site 1168287003584 anticodon binding site; other site 1168287003585 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1168287003586 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1168287003587 active site 1168287003588 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168287003589 substrate binding site [chemical binding]; other site 1168287003590 catalytic residues [active] 1168287003591 dimer interface [polypeptide binding]; other site 1168287003592 homoserine dehydrogenase; Provisional; Region: PRK06349 1168287003593 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1168287003594 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1168287003595 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1168287003596 threonine synthase; Reviewed; Region: PRK06721 1168287003597 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1168287003598 homodimer interface [polypeptide binding]; other site 1168287003599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287003600 catalytic residue [active] 1168287003601 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1168287003602 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1168287003603 transcription termination factor Rho; Provisional; Region: PRK12608 1168287003604 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1168287003605 RNA binding site [nucleotide binding]; other site 1168287003606 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1168287003607 multimer interface [polypeptide binding]; other site 1168287003608 Walker A motif; other site 1168287003609 ATP binding site [chemical binding]; other site 1168287003610 Walker B motif; other site 1168287003611 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1168287003612 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1168287003613 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1168287003614 RF-1 domain; Region: RF-1; pfam00472 1168287003615 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1168287003616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287003617 S-adenosylmethionine binding site [chemical binding]; other site 1168287003618 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1168287003619 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1168287003620 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1168287003621 Mg++ binding site [ion binding]; other site 1168287003622 putative catalytic motif [active] 1168287003623 substrate binding site [chemical binding]; other site 1168287003624 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1168287003625 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1168287003626 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1168287003627 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1168287003628 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1168287003629 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1168287003630 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1168287003631 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1168287003632 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1168287003633 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1168287003634 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1168287003635 beta subunit interaction interface [polypeptide binding]; other site 1168287003636 Walker A motif; other site 1168287003637 ATP binding site [chemical binding]; other site 1168287003638 Walker B motif; other site 1168287003639 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1168287003640 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1168287003641 core domain interface [polypeptide binding]; other site 1168287003642 delta subunit interface [polypeptide binding]; other site 1168287003643 epsilon subunit interface [polypeptide binding]; other site 1168287003644 farnesyltranstransferase subunit beta; Region: PLN02710 1168287003645 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1168287003646 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1168287003647 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1168287003648 alpha subunit interaction interface [polypeptide binding]; other site 1168287003649 Walker A motif; other site 1168287003650 ATP binding site [chemical binding]; other site 1168287003651 Walker B motif; other site 1168287003652 inhibitor binding site; inhibition site 1168287003653 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1168287003654 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1168287003655 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1168287003656 gamma subunit interface [polypeptide binding]; other site 1168287003657 epsilon subunit interface [polypeptide binding]; other site 1168287003658 LBP interface [polypeptide binding]; other site 1168287003659 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1168287003660 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1168287003661 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1168287003662 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1168287003663 hinge; other site 1168287003664 active site 1168287003665 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1168287003666 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287003667 PPE family; Region: PPE; pfam00823 1168287003668 PE family; Region: PE; pfam00934 1168287003669 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287003670 PPE family; Region: PPE; pfam00823 1168287003671 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287003672 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1168287003673 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1168287003674 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1168287003675 DNA binding site [nucleotide binding] 1168287003676 active site 1168287003677 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1168287003678 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1168287003679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287003680 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1168287003681 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1168287003682 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168287003683 minor groove reading motif; other site 1168287003684 helix-hairpin-helix signature motif; other site 1168287003685 substrate binding pocket [chemical binding]; other site 1168287003686 active site 1168287003687 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1168287003688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1168287003689 metal binding site [ion binding]; metal-binding site 1168287003690 active site 1168287003691 I-site; other site 1168287003692 HAMP domain; Region: HAMP; pfam00672 1168287003693 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287003694 cyclase homology domain; Region: CHD; cd07302 1168287003695 nucleotidyl binding site; other site 1168287003696 metal binding site [ion binding]; metal-binding site 1168287003697 dimer interface [polypeptide binding]; other site 1168287003698 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1168287003699 hypothetical protein; Provisional; Region: PRK03298 1168287003700 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1168287003701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287003702 dimer interface [polypeptide binding]; other site 1168287003703 substrate binding site [chemical binding]; other site 1168287003704 metal binding site [ion binding]; metal-binding site 1168287003705 putative acyltransferase; Provisional; Region: PRK05790 1168287003706 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287003707 dimer interface [polypeptide binding]; other site 1168287003708 active site 1168287003709 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1168287003710 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1168287003711 glycogen branching enzyme; Provisional; Region: PRK05402 1168287003712 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1168287003713 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1168287003714 active site 1168287003715 catalytic site [active] 1168287003716 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1168287003717 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1168287003718 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168287003719 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1168287003720 active site 1168287003721 homodimer interface [polypeptide binding]; other site 1168287003722 catalytic site [active] 1168287003723 acceptor binding site [chemical binding]; other site 1168287003724 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1168287003725 putative homodimer interface [polypeptide binding]; other site 1168287003726 putative active site pocket [active] 1168287003727 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1168287003728 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1168287003729 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1168287003730 ATP binding site [chemical binding]; other site 1168287003731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168287003732 putative Mg++ binding site [ion binding]; other site 1168287003733 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1168287003734 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1168287003735 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1168287003736 active site 1168287003737 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1168287003738 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1168287003739 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1168287003740 putative active site pocket [active] 1168287003741 cleavage site 1168287003742 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1168287003743 glutamate racemase; Provisional; Region: PRK00865 1168287003744 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1168287003745 ribonuclease PH; Reviewed; Region: rph; PRK00173 1168287003746 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1168287003747 hexamer interface [polypeptide binding]; other site 1168287003748 active site 1168287003749 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1168287003750 active site 1168287003751 dimerization interface [polypeptide binding]; other site 1168287003752 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1168287003753 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1168287003754 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1168287003755 Protein of unknown function, DUF393; Region: DUF393; cl01136 1168287003756 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1168287003757 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1168287003758 FAD binding pocket [chemical binding]; other site 1168287003759 FAD binding motif [chemical binding]; other site 1168287003760 phosphate binding motif [ion binding]; other site 1168287003761 NAD binding pocket [chemical binding]; other site 1168287003762 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168287003763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287003764 Walker A/P-loop; other site 1168287003765 ATP binding site [chemical binding]; other site 1168287003766 Q-loop/lid; other site 1168287003767 ABC transporter signature motif; other site 1168287003768 Walker B; other site 1168287003769 D-loop; other site 1168287003770 H-loop/switch region; other site 1168287003771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287003772 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168287003773 Walker A/P-loop; other site 1168287003774 ATP binding site [chemical binding]; other site 1168287003775 Q-loop/lid; other site 1168287003776 ABC transporter signature motif; other site 1168287003777 Walker B; other site 1168287003778 D-loop; other site 1168287003779 H-loop/switch region; other site 1168287003780 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287003781 Ecdysteroid kinase; Region: EcKinase; cl17738 1168287003782 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1168287003783 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287003784 classical (c) SDRs; Region: SDR_c; cd05233 1168287003785 NAD(P) binding site [chemical binding]; other site 1168287003786 active site 1168287003787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003789 active site 1168287003790 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287003791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003792 NAD(P) binding site [chemical binding]; other site 1168287003793 active site 1168287003794 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1168287003795 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287003796 dimer interface [polypeptide binding]; other site 1168287003797 active site 1168287003798 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1168287003799 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287003800 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003802 active site 1168287003803 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1168287003804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287003805 DNA-binding site [nucleotide binding]; DNA binding site 1168287003806 FCD domain; Region: FCD; pfam07729 1168287003807 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287003808 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287003809 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287003810 acyl-activating enzyme (AAE) consensus motif; other site 1168287003811 acyl-activating enzyme (AAE) consensus motif; other site 1168287003812 AMP binding site [chemical binding]; other site 1168287003813 active site 1168287003814 CoA binding site [chemical binding]; other site 1168287003815 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287003816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287003817 acyl-activating enzyme (AAE) consensus motif; other site 1168287003818 AMP binding site [chemical binding]; other site 1168287003819 active site 1168287003820 CoA binding site [chemical binding]; other site 1168287003821 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287003822 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287003823 AMP binding site [chemical binding]; other site 1168287003824 active site 1168287003825 acyl-activating enzyme (AAE) consensus motif; other site 1168287003826 CoA binding site [chemical binding]; other site 1168287003827 enoyl-CoA hydratase; Provisional; Region: PRK05981 1168287003828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287003829 substrate binding site [chemical binding]; other site 1168287003830 oxyanion hole (OAH) forming residues; other site 1168287003831 trimer interface [polypeptide binding]; other site 1168287003832 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287003833 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287003834 substrate binding site [chemical binding]; other site 1168287003835 oxyanion hole (OAH) forming residues; other site 1168287003836 trimer interface [polypeptide binding]; other site 1168287003837 enoyl-CoA hydratase; Provisional; Region: PRK06688 1168287003838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287003839 substrate binding site [chemical binding]; other site 1168287003840 oxyanion hole (OAH) forming residues; other site 1168287003841 trimer interface [polypeptide binding]; other site 1168287003842 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287003843 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1168287003844 substrate binding site [chemical binding]; other site 1168287003845 oxyanion hole (OAH) forming residues; other site 1168287003846 trimer interface [polypeptide binding]; other site 1168287003847 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1168287003848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003849 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1168287003850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287003851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287003852 NAD(P) binding site [chemical binding]; other site 1168287003853 active site 1168287003854 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1168287003855 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1168287003856 active site 1168287003857 inhibitor site; inhibition site 1168287003858 dimer interface [polypeptide binding]; other site 1168287003859 catalytic residue [active] 1168287003860 CsbD-like; Region: CsbD; cl17424 1168287003861 enoyl-CoA hydratase; Provisional; Region: PRK06210 1168287003862 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287003863 substrate binding site [chemical binding]; other site 1168287003864 oxyanion hole (OAH) forming residues; other site 1168287003865 trimer interface [polypeptide binding]; other site 1168287003866 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287003867 acyl-CoA synthetase; Validated; Region: PRK07798 1168287003868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287003869 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1168287003870 acyl-activating enzyme (AAE) consensus motif; other site 1168287003871 acyl-activating enzyme (AAE) consensus motif; other site 1168287003872 putative AMP binding site [chemical binding]; other site 1168287003873 putative active site [active] 1168287003874 putative CoA binding site [chemical binding]; other site 1168287003875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287003876 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1168287003877 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287003878 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003879 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003880 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003881 active site 1168287003882 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287003883 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1168287003884 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287003885 active site 1168287003886 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287003887 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287003888 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287003889 Cytochrome P450; Region: p450; cl12078 1168287003890 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287003891 NAD(P) binding site [chemical binding]; other site 1168287003892 catalytic residues [active] 1168287003893 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287003894 Cytochrome P450; Region: p450; cl12078 1168287003895 short chain dehydrogenase; Provisional; Region: PRK07832 1168287003896 classical (c) SDRs; Region: SDR_c; cd05233 1168287003897 NAD(P) binding site [chemical binding]; other site 1168287003898 active site 1168287003899 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287003900 hydrophobic ligand binding site; other site 1168287003901 acyl-CoA synthetase; Validated; Region: PRK07798 1168287003902 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287003903 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1168287003904 acyl-activating enzyme (AAE) consensus motif; other site 1168287003905 acyl-activating enzyme (AAE) consensus motif; other site 1168287003906 putative AMP binding site [chemical binding]; other site 1168287003907 putative active site [active] 1168287003908 putative CoA binding site [chemical binding]; other site 1168287003909 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287003910 CoenzymeA binding site [chemical binding]; other site 1168287003911 subunit interaction site [polypeptide binding]; other site 1168287003912 PHB binding site; other site 1168287003913 Isochorismatase family; Region: Isochorismatase; pfam00857 1168287003914 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1168287003915 catalytic triad [active] 1168287003916 conserved cis-peptide bond; other site 1168287003917 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287003918 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287003919 [2Fe-2S] cluster binding site [ion binding]; other site 1168287003920 potential frameshift: common BLAST hit: gi|379753685|ref|YP_005342357.1| bile-acid 7-alpha dehydratase 1168287003921 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287003922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287003923 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1168287003924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287003925 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287003926 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1168287003927 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287003928 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287003929 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168287003930 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168287003931 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287003932 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287003933 Cytochrome P450; Region: p450; cl12078 1168287003934 potential frameshift: common BLAST hit: gi|379760884|ref|YP_005347281.1| short chain dehydrogenase 1168287003935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287003938 Walker A/P-loop; other site 1168287003939 ATP binding site [chemical binding]; other site 1168287003940 Predicted membrane protein [Function unknown]; Region: COG1511 1168287003941 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1168287003942 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1168287003943 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1168287003944 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1168287003945 NAD binding site [chemical binding]; other site 1168287003946 catalytic Zn binding site [ion binding]; other site 1168287003947 substrate binding site [chemical binding]; other site 1168287003948 structural Zn binding site [ion binding]; other site 1168287003949 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287003950 Cytochrome P450; Region: p450; cl12078 1168287003951 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287003952 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287003953 substrate binding pocket [chemical binding]; other site 1168287003954 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003955 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287003956 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287003957 active site 1168287003958 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003959 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003960 active site 1168287003961 PAS fold; Region: PAS_4; pfam08448 1168287003962 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1168287003963 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1168287003964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1168287003965 ATP binding site [chemical binding]; other site 1168287003966 Mg2+ binding site [ion binding]; other site 1168287003967 G-X-G motif; other site 1168287003968 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287003969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287003970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287003971 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287003972 CoenzymeA binding site [chemical binding]; other site 1168287003973 subunit interaction site [polypeptide binding]; other site 1168287003974 PHB binding site; other site 1168287003975 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287003976 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287003977 putative AMP binding site [chemical binding]; other site 1168287003978 putative active site [active] 1168287003979 acyl-activating enzyme (AAE) consensus motif; other site 1168287003980 putative CoA binding site [chemical binding]; other site 1168287003981 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1168287003982 active site 1168287003983 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003984 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003985 active site 1168287003986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003988 active site 1168287003989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287003990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287003991 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287003992 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287003993 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1168287003994 classical (c) SDRs; Region: SDR_c; cd05233 1168287003995 NAD(P) binding site [chemical binding]; other site 1168287003996 active site 1168287003997 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1168287003998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287003999 DNA-binding site [nucleotide binding]; DNA binding site 1168287004000 FCD domain; Region: FCD; pfam07729 1168287004001 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287004002 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287004003 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287004004 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287004005 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287004006 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1168287004007 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004008 Cytochrome P450; Region: p450; cl12078 1168287004009 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287004010 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287004011 [2Fe-2S] cluster binding site [ion binding]; other site 1168287004012 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287004013 hydrophobic ligand binding site; other site 1168287004014 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1168287004015 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1168287004016 acyl-activating enzyme (AAE) consensus motif; other site 1168287004017 putative AMP binding site [chemical binding]; other site 1168287004018 putative active site [active] 1168287004019 putative CoA binding site [chemical binding]; other site 1168287004020 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287004021 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1168287004022 active site 1168287004023 catalytic site [active] 1168287004024 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1168287004025 putative active site [active] 1168287004026 putative catalytic site [active] 1168287004027 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1168287004028 TIGR03086 family protein; Region: TIGR03086 1168287004029 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1168287004030 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287004031 NAD binding site [chemical binding]; other site 1168287004032 catalytic residues [active] 1168287004033 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1168287004034 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287004035 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287004036 [2Fe-2S] cluster binding site [ion binding]; other site 1168287004037 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1168287004038 putative alpha subunit interface [polypeptide binding]; other site 1168287004039 putative active site [active] 1168287004040 putative substrate binding site [chemical binding]; other site 1168287004041 Fe binding site [ion binding]; other site 1168287004042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287004043 sequence-specific DNA binding site [nucleotide binding]; other site 1168287004044 salt bridge; other site 1168287004045 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1168287004046 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1168287004047 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1168287004048 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168287004049 phosphate binding site [ion binding]; other site 1168287004050 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1168287004051 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1168287004052 putative active site [active] 1168287004053 putative catalytic site [active] 1168287004054 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1168287004055 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168287004056 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1168287004057 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1168287004058 putative NAD(P) binding site [chemical binding]; other site 1168287004059 active site 1168287004060 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1168287004061 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1168287004062 active site 1168287004063 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1168287004064 hypothetical protein; Provisional; Region: PRK07907 1168287004065 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1168287004066 active site 1168287004067 metal binding site [ion binding]; metal-binding site 1168287004068 dimer interface [polypeptide binding]; other site 1168287004069 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287004070 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004071 Cytochrome P450; Region: p450; cl12078 1168287004072 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1168287004073 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168287004074 catalytic triad [active] 1168287004075 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1168287004076 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1168287004077 hypothetical protein; Provisional; Region: PRK01346 1168287004078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1168287004079 MMPL family; Region: MMPL; pfam03176 1168287004080 MMPL family; Region: MMPL; pfam03176 1168287004081 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1168287004082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1168287004083 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1168287004084 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168287004085 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1168287004086 catalytic site [active] 1168287004087 putative active site [active] 1168287004088 putative substrate binding site [chemical binding]; other site 1168287004089 dimer interface [polypeptide binding]; other site 1168287004090 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1168287004091 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287004092 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287004093 Integrase core domain; Region: rve; pfam00665 1168287004094 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168287004095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004096 NAD(P) binding site [chemical binding]; other site 1168287004097 active site 1168287004098 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1168287004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287004100 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287004101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004103 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1168287004104 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168287004105 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287004106 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1168287004107 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168287004108 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1168287004109 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168287004110 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168287004111 carboxyltransferase (CT) interaction site; other site 1168287004112 biotinylation site [posttranslational modification]; other site 1168287004113 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287004114 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287004115 active site 1168287004116 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1168287004117 putative active site [active] 1168287004118 putative catalytic site [active] 1168287004119 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1168287004120 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1168287004121 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1168287004122 tetramer interface [polypeptide binding]; other site 1168287004123 TPP-binding site [chemical binding]; other site 1168287004124 heterodimer interface [polypeptide binding]; other site 1168287004125 phosphorylation loop region [posttranslational modification] 1168287004126 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1168287004127 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1168287004128 alpha subunit interface [polypeptide binding]; other site 1168287004129 TPP binding site [chemical binding]; other site 1168287004130 heterodimer interface [polypeptide binding]; other site 1168287004131 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168287004132 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168287004133 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1168287004134 E3 interaction surface; other site 1168287004135 lipoyl attachment site [posttranslational modification]; other site 1168287004136 e3 binding domain; Region: E3_binding; pfam02817 1168287004137 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1168287004138 enoyl-CoA hydratase; Provisional; Region: PRK05870 1168287004139 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287004140 substrate binding site [chemical binding]; other site 1168287004141 oxyanion hole (OAH) forming residues; other site 1168287004142 trimer interface [polypeptide binding]; other site 1168287004143 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1168287004144 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287004145 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287004146 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287004147 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287004148 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1168287004149 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1168287004150 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287004151 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168287004152 putative acyl-acceptor binding pocket; other site 1168287004153 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1168287004154 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1168287004155 putative acyl-acceptor binding pocket; other site 1168287004156 Copper resistance protein D; Region: CopD; pfam05425 1168287004157 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1168287004158 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1168287004159 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1168287004160 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1168287004161 dimer interface [polypeptide binding]; other site 1168287004162 ssDNA binding site [nucleotide binding]; other site 1168287004163 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168287004164 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1168287004165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287004166 Walker A/P-loop; other site 1168287004167 ATP binding site [chemical binding]; other site 1168287004168 Q-loop/lid; other site 1168287004169 ABC transporter signature motif; other site 1168287004170 Walker B; other site 1168287004171 D-loop; other site 1168287004172 H-loop/switch region; other site 1168287004173 ABC transporter; Region: ABC_tran_2; pfam12848 1168287004174 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168287004175 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1168287004176 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1168287004177 active site 1168287004178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287004179 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1168287004180 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168287004181 active site 1168287004182 catalytic site [active] 1168287004183 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1168287004184 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1168287004185 apolar tunnel; other site 1168287004186 heme binding site [chemical binding]; other site 1168287004187 dimerization interface [polypeptide binding]; other site 1168287004188 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1168287004189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287004190 active site 1168287004191 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1168287004192 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1168287004193 Zn binding site [ion binding]; other site 1168287004194 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1168287004195 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1168287004196 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1168287004197 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1168287004198 putative DNA binding site [nucleotide binding]; other site 1168287004199 catalytic residue [active] 1168287004200 putative H2TH interface [polypeptide binding]; other site 1168287004201 putative catalytic residues [active] 1168287004202 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168287004203 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1168287004204 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287004205 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287004206 trigger factor; Provisional; Region: tig; PRK01490 1168287004207 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1168287004208 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1168287004209 Clp protease; Region: CLP_protease; pfam00574 1168287004210 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1168287004211 oligomer interface [polypeptide binding]; other site 1168287004212 active site residues [active] 1168287004213 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1168287004214 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1168287004215 oligomer interface [polypeptide binding]; other site 1168287004216 active site residues [active] 1168287004217 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1168287004218 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1168287004219 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1168287004220 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1168287004221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287004222 Walker A motif; other site 1168287004223 ATP binding site [chemical binding]; other site 1168287004224 Walker B motif; other site 1168287004225 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1168287004226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168287004227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287004228 putative substrate translocation pore; other site 1168287004229 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1168287004230 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1168287004231 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1168287004232 dimer interface [polypeptide binding]; other site 1168287004233 PYR/PP interface [polypeptide binding]; other site 1168287004234 TPP binding site [chemical binding]; other site 1168287004235 substrate binding site [chemical binding]; other site 1168287004236 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1168287004237 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1168287004238 TPP-binding site [chemical binding]; other site 1168287004239 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1168287004240 GTP binding site; other site 1168287004241 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1168287004242 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1168287004243 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1168287004244 NAD(P) binding pocket [chemical binding]; other site 1168287004245 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1168287004246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287004247 active site 1168287004248 HIGH motif; other site 1168287004249 nucleotide binding site [chemical binding]; other site 1168287004250 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1168287004251 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1168287004252 active site 1168287004253 KMSKS motif; other site 1168287004254 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1168287004255 tRNA binding surface [nucleotide binding]; other site 1168287004256 anticodon binding site; other site 1168287004257 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1168287004258 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1168287004259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168287004260 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1168287004261 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1168287004262 active site 1168287004263 multimer interface [polypeptide binding]; other site 1168287004264 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1168287004265 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1168287004266 homodimer interface [polypeptide binding]; other site 1168287004267 oligonucleotide binding site [chemical binding]; other site 1168287004268 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1168287004269 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1168287004270 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1168287004271 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1168287004272 GTP1/OBG; Region: GTP1_OBG; pfam01018 1168287004273 Obg GTPase; Region: Obg; cd01898 1168287004274 G1 box; other site 1168287004275 GTP/Mg2+ binding site [chemical binding]; other site 1168287004276 Switch I region; other site 1168287004277 G2 box; other site 1168287004278 G3 box; other site 1168287004279 Switch II region; other site 1168287004280 G4 box; other site 1168287004281 G5 box; other site 1168287004282 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1168287004283 gamma-glutamyl kinase; Provisional; Region: PRK05429 1168287004284 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1168287004285 nucleotide binding site [chemical binding]; other site 1168287004286 homotetrameric interface [polypeptide binding]; other site 1168287004287 putative phosphate binding site [ion binding]; other site 1168287004288 putative allosteric binding site; other site 1168287004289 PUA domain; Region: PUA; pfam01472 1168287004290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004292 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004293 Cytochrome P450; Region: p450; cl12078 1168287004294 NAD-dependent deacetylase; Provisional; Region: PRK00481 1168287004295 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1168287004296 NAD+ binding site [chemical binding]; other site 1168287004297 substrate binding site [chemical binding]; other site 1168287004298 Zn binding site [ion binding]; other site 1168287004299 Isochorismatase family; Region: Isochorismatase; pfam00857 1168287004300 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1168287004301 catalytic triad [active] 1168287004302 conserved cis-peptide bond; other site 1168287004303 NAD synthetase; Reviewed; Region: nadE; PRK02628 1168287004304 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1168287004305 multimer interface [polypeptide binding]; other site 1168287004306 active site 1168287004307 catalytic triad [active] 1168287004308 protein interface 1 [polypeptide binding]; other site 1168287004309 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1168287004310 homodimer interface [polypeptide binding]; other site 1168287004311 NAD binding pocket [chemical binding]; other site 1168287004312 ATP binding pocket [chemical binding]; other site 1168287004313 Mg binding site [ion binding]; other site 1168287004314 active-site loop [active] 1168287004315 potential frameshift: common BLAST hit: gi|183982629|ref|YP_001850920.1| transposase for ISMyma06 1168287004316 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1168287004317 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168287004318 substrate binding site [chemical binding]; other site 1168287004319 dimer interface [polypeptide binding]; other site 1168287004320 ATP binding site [chemical binding]; other site 1168287004321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168287004322 dimerization interface [polypeptide binding]; other site 1168287004323 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1168287004324 cyclase homology domain; Region: CHD; cd07302 1168287004325 nucleotidyl binding site; other site 1168287004326 metal binding site [ion binding]; metal-binding site 1168287004327 dimer interface [polypeptide binding]; other site 1168287004328 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1168287004329 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1168287004330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168287004331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168287004332 ligand binding site [chemical binding]; other site 1168287004333 flexible hinge region; other site 1168287004334 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1168287004335 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1168287004336 putative catalytic cysteine [active] 1168287004337 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1168287004338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287004339 Walker A motif; other site 1168287004340 ATP binding site [chemical binding]; other site 1168287004341 Walker B motif; other site 1168287004342 arginine finger; other site 1168287004343 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1168287004344 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1168287004345 metal ion-dependent adhesion site (MIDAS); other site 1168287004346 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1168287004347 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1168287004348 active site 1168287004349 (T/H)XGH motif; other site 1168287004350 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1168287004351 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287004352 catalytic core [active] 1168287004353 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1168287004354 active site 1168287004355 catalytic triad [active] 1168287004356 oxyanion hole [active] 1168287004357 EDD domain protein, DegV family; Region: DegV; TIGR00762 1168287004358 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1168287004359 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168287004360 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287004361 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287004362 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 1168287004363 acyl-CoA synthetase; Validated; Region: PRK05850 1168287004364 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1168287004365 acyl-activating enzyme (AAE) consensus motif; other site 1168287004366 active site 1168287004367 PE-PPE domain; Region: PE-PPE; pfam08237 1168287004368 Transport protein; Region: actII; TIGR00833 1168287004369 Condensation domain; Region: Condensation; pfam00668 1168287004370 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287004371 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1168287004372 active site 1168287004373 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168287004374 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287004375 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1168287004376 KR domain; Region: KR; pfam08659 1168287004377 putative NADP binding site [chemical binding]; other site 1168287004378 active site 1168287004379 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287004380 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168287004381 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287004382 active site 1168287004383 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287004384 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1168287004385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004386 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1168287004387 Enoylreductase; Region: PKS_ER; smart00829 1168287004388 NAD(P) binding site [chemical binding]; other site 1168287004389 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1168287004390 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287004391 putative NADP binding site [chemical binding]; other site 1168287004392 active site 1168287004393 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287004394 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1168287004395 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1168287004396 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287004397 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287004398 active site 1168287004399 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1168287004400 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1168287004401 FAD binding site [chemical binding]; other site 1168287004402 substrate binding site [chemical binding]; other site 1168287004403 catalytic base [active] 1168287004404 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1168287004405 Helix-hairpin-helix motif; Region: HHH; pfam00633 1168287004406 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1168287004407 Competence protein; Region: Competence; pfam03772 1168287004408 hypothetical protein; Reviewed; Region: PRK07914 1168287004409 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1168287004410 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1168287004411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1168287004412 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1168287004413 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1168287004414 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1168287004415 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1168287004416 Predicted transcriptional regulators [Transcription]; Region: COG1733 1168287004417 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1168287004418 DoxX-like family; Region: DoxX_2; pfam13564 1168287004419 ribonuclease Z; Reviewed; Region: PRK00055 1168287004420 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1168287004421 FOG: CBS domain [General function prediction only]; Region: COG0517 1168287004422 PemK-like protein; Region: PemK; pfam02452 1168287004423 GTP-binding protein LepA; Provisional; Region: PRK05433 1168287004424 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1168287004425 putative GEF interaction site [polypeptide binding]; other site 1168287004426 Switch I region; other site 1168287004427 G2 box; other site 1168287004428 G3 box; other site 1168287004429 Switch II region; other site 1168287004430 GTP/Mg2+ binding site [chemical binding]; other site 1168287004431 G4 box; other site 1168287004432 G5 box; other site 1168287004433 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1168287004434 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1168287004435 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1168287004436 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287004437 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287004438 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1168287004439 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1168287004440 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1168287004441 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1168287004442 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1168287004443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287004444 dimer interface [polypeptide binding]; other site 1168287004445 conserved gate region; other site 1168287004446 putative PBP binding loops; other site 1168287004447 ABC-ATPase subunit interface; other site 1168287004448 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1168287004449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287004450 dimer interface [polypeptide binding]; other site 1168287004451 conserved gate region; other site 1168287004452 putative PBP binding loops; other site 1168287004453 ABC-ATPase subunit interface; other site 1168287004454 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1168287004455 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1168287004456 Walker A/P-loop; other site 1168287004457 ATP binding site [chemical binding]; other site 1168287004458 Q-loop/lid; other site 1168287004459 ABC transporter signature motif; other site 1168287004460 Walker B; other site 1168287004461 D-loop; other site 1168287004462 H-loop/switch region; other site 1168287004463 TOBE domain; Region: TOBE; pfam03459 1168287004464 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1168287004465 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1168287004466 Active Sites [active] 1168287004467 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1168287004468 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1168287004469 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1168287004470 chaperone protein DnaJ; Provisional; Region: PRK14297 1168287004471 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1168287004472 HemN C-terminal domain; Region: HemN_C; pfam06969 1168287004473 Predicted permease [General function prediction only]; Region: COG3329 1168287004474 salicylate synthase MbtI; Reviewed; Region: PRK07912 1168287004475 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1168287004476 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1168287004477 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168287004478 DNA binding residues [nucleotide binding] 1168287004479 putative dimer interface [polypeptide binding]; other site 1168287004480 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287004481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287004482 classical (c) SDRs; Region: SDR_c; cd05233 1168287004483 short chain dehydrogenase; Provisional; Region: PRK05650 1168287004484 NAD(P) binding site [chemical binding]; other site 1168287004485 active site 1168287004486 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1168287004487 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1168287004488 DNA methylase; Region: N6_N4_Mtase; cl17433 1168287004489 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1168287004490 Protein of unknown function DUF262; Region: DUF262; pfam03235 1168287004491 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1168287004492 FIC domain binding interface [polypeptide binding]; other site 1168287004493 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1168287004494 Integrase core domain; Region: rve; pfam00665 1168287004495 AAA domain; Region: AAA_22; pfam13401 1168287004496 Bacterial TniB protein; Region: TniB; pfam05621 1168287004497 TniQ; Region: TniQ; pfam06527 1168287004498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168287004499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287004500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287004501 sequence-specific DNA binding site [nucleotide binding]; other site 1168287004502 salt bridge; other site 1168287004503 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1168287004504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287004505 Walker A motif; other site 1168287004506 ATP binding site [chemical binding]; other site 1168287004507 Walker B motif; other site 1168287004508 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287004509 MULE transposase domain; Region: MULE; pfam10551 1168287004510 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1168287004511 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1168287004512 Walker A/P-loop; other site 1168287004513 ATP binding site [chemical binding]; other site 1168287004514 Q-loop/lid; other site 1168287004515 ABC transporter signature motif; other site 1168287004516 Walker B; other site 1168287004517 D-loop; other site 1168287004518 H-loop/switch region; other site 1168287004519 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287004520 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287004521 classical (c) SDRs; Region: SDR_c; cd05233 1168287004522 NAD(P) binding site [chemical binding]; other site 1168287004523 active site 1168287004524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004525 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1168287004526 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1168287004527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004529 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1168287004530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004531 NAD(P) binding site [chemical binding]; other site 1168287004532 active site 1168287004533 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1168287004534 putative active site [active] 1168287004535 putative CoA binding site [chemical binding]; other site 1168287004536 nudix motif; other site 1168287004537 metal binding site [ion binding]; metal-binding site 1168287004538 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1168287004539 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287004540 cyclase homology domain; Region: CHD; cd07302 1168287004541 nucleotidyl binding site; other site 1168287004542 metal binding site [ion binding]; metal-binding site 1168287004543 dimer interface [polypeptide binding]; other site 1168287004544 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1168287004545 active site 1168287004546 catalytic residues [active] 1168287004547 metal binding site [ion binding]; metal-binding site 1168287004548 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287004549 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287004550 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1168287004551 TPP-binding site [chemical binding]; other site 1168287004552 PYR/PP interface [polypeptide binding]; other site 1168287004553 dimer interface [polypeptide binding]; other site 1168287004554 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1168287004555 TPP binding site [chemical binding]; other site 1168287004556 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168287004557 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1168287004558 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1168287004559 FMN-binding pocket [chemical binding]; other site 1168287004560 flavin binding motif; other site 1168287004561 phosphate binding motif [ion binding]; other site 1168287004562 beta-alpha-beta structure motif; other site 1168287004563 NAD binding pocket [chemical binding]; other site 1168287004564 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287004565 catalytic loop [active] 1168287004566 iron binding site [ion binding]; other site 1168287004567 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004568 Cytochrome P450; Region: p450; cl12078 1168287004569 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287004570 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287004571 active site 1168287004572 metal binding site [ion binding]; metal-binding site 1168287004573 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168287004574 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287004575 Berberine and berberine like; Region: BBE; pfam08031 1168287004576 hypothetical protein; Provisional; Region: PRK06847 1168287004577 hypothetical protein; Provisional; Region: PRK07236 1168287004578 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1168287004579 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1168287004580 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1168287004581 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1168287004582 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1168287004583 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1168287004584 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287004585 active site 1168287004586 metal binding site [ion binding]; metal-binding site 1168287004587 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287004588 active site 1168287004589 metal binding site [ion binding]; metal-binding site 1168287004590 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287004591 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287004592 active site 1168287004593 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1168287004594 active site 1168287004595 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1168287004596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004597 acyl-activating enzyme (AAE) consensus motif; other site 1168287004598 AMP binding site [chemical binding]; other site 1168287004599 active site 1168287004600 CoA binding site [chemical binding]; other site 1168287004601 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 1168287004602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004604 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1168287004605 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168287004606 E3 interaction surface; other site 1168287004607 lipoyl attachment site [posttranslational modification]; other site 1168287004608 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168287004609 E3 interaction surface; other site 1168287004610 lipoyl attachment site [posttranslational modification]; other site 1168287004611 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1168287004612 YCII-related domain; Region: YCII; cl00999 1168287004613 Permease; Region: Permease; pfam02405 1168287004614 Permease; Region: Permease; pfam02405 1168287004615 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287004616 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1168287004617 mce related protein; Region: MCE; pfam02470 1168287004618 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287004619 mce related protein; Region: MCE; pfam02470 1168287004620 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287004621 mce related protein; Region: MCE; pfam02470 1168287004622 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287004623 mce related protein; Region: MCE; pfam02470 1168287004624 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1168287004625 mce related protein; Region: MCE; pfam02470 1168287004626 potential frameshift: common BLAST hit: gi|118466907|ref|YP_884207.1| oxidoreductase, short chain dehydrogenase/reductase 1168287004627 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287004628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287004629 substrate binding site [chemical binding]; other site 1168287004630 oxyanion hole (OAH) forming residues; other site 1168287004631 trimer interface [polypeptide binding]; other site 1168287004632 enoyl-CoA hydratase; Provisional; Region: PRK06688 1168287004633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287004634 substrate binding site [chemical binding]; other site 1168287004635 oxyanion hole (OAH) forming residues; other site 1168287004636 trimer interface [polypeptide binding]; other site 1168287004637 enoyl-CoA hydratase; Provisional; Region: PRK06688 1168287004638 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287004639 substrate binding site [chemical binding]; other site 1168287004640 oxyanion hole (OAH) forming residues; other site 1168287004641 trimer interface [polypeptide binding]; other site 1168287004642 AMP-binding domain protein; Validated; Region: PRK08315 1168287004643 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004644 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1168287004645 acyl-activating enzyme (AAE) consensus motif; other site 1168287004646 acyl-activating enzyme (AAE) consensus motif; other site 1168287004647 putative AMP binding site [chemical binding]; other site 1168287004648 putative active site [active] 1168287004649 putative CoA binding site [chemical binding]; other site 1168287004650 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1168287004651 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1168287004652 iron-sulfur cluster [ion binding]; other site 1168287004653 [2Fe-2S] cluster binding site [ion binding]; other site 1168287004654 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1168287004655 putative alpha subunit interface [polypeptide binding]; other site 1168287004656 putative active site [active] 1168287004657 putative substrate binding site [chemical binding]; other site 1168287004658 Fe binding site [ion binding]; other site 1168287004659 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1168287004660 inter-subunit interface; other site 1168287004661 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1168287004662 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287004663 dimer interface [polypeptide binding]; other site 1168287004664 active site 1168287004665 hypothetical protein; Provisional; Region: PRK04262 1168287004666 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287004667 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287004668 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 1168287004669 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287004670 active site 1168287004671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004673 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287004674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287004675 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1168287004676 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287004677 putative active site [active] 1168287004678 putative substrate binding site [chemical binding]; other site 1168287004679 ATP binding site [chemical binding]; other site 1168287004680 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1168287004681 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1168287004682 Walker A/P-loop; other site 1168287004683 ATP binding site [chemical binding]; other site 1168287004684 Q-loop/lid; other site 1168287004685 ABC transporter signature motif; other site 1168287004686 Walker B; other site 1168287004687 D-loop; other site 1168287004688 H-loop/switch region; other site 1168287004689 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1168287004690 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1168287004691 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004692 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287004693 acyl-activating enzyme (AAE) consensus motif; other site 1168287004694 putative AMP binding site [chemical binding]; other site 1168287004695 putative active site [active] 1168287004696 acyl-activating enzyme (AAE) consensus motif; other site 1168287004697 putative CoA binding site [chemical binding]; other site 1168287004698 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004699 Cytochrome P450; Region: p450; cl12078 1168287004700 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168287004701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004702 NAD(P) binding site [chemical binding]; other site 1168287004703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004704 active site 1168287004705 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1168287004706 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1168287004707 NAD(P) binding site [chemical binding]; other site 1168287004708 catalytic residues [active] 1168287004709 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1168287004710 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287004711 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1168287004712 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287004713 ferredoxin-NADP+ reductase; Region: PLN02852 1168287004714 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287004715 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287004716 active site 2 [active] 1168287004717 active site 1 [active] 1168287004718 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1168287004719 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1168287004720 NAD(P) binding site [chemical binding]; other site 1168287004721 catalytic residues [active] 1168287004722 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1168287004723 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287004724 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287004725 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287004726 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1168287004727 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1168287004728 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004729 Cytochrome P450; Region: p450; cl12078 1168287004730 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287004731 classical (c) SDRs; Region: SDR_c; cd05233 1168287004732 NAD(P) binding site [chemical binding]; other site 1168287004733 active site 1168287004734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004736 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287004737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287004738 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287004739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004740 NAD(P) binding site [chemical binding]; other site 1168287004741 active site 1168287004742 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1168287004743 putative hydrophobic ligand binding site [chemical binding]; other site 1168287004744 protein interface [polypeptide binding]; other site 1168287004745 gate; other site 1168287004746 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287004747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004748 NAD(P) binding site [chemical binding]; other site 1168287004749 active site 1168287004750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004751 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1168287004752 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287004753 FMN binding site [chemical binding]; other site 1168287004754 substrate binding site [chemical binding]; other site 1168287004755 putative catalytic residue [active] 1168287004756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287004757 enoyl-CoA hydratase; Provisional; Region: PRK06495 1168287004758 substrate binding site [chemical binding]; other site 1168287004759 oxyanion hole (OAH) forming residues; other site 1168287004760 trimer interface [polypeptide binding]; other site 1168287004761 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168287004762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004763 NAD(P) binding site [chemical binding]; other site 1168287004764 active site 1168287004765 Ecdysteroid kinase; Region: EcKinase; cl17738 1168287004766 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287004767 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 1168287004768 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1168287004769 putative catalytic cysteine [active] 1168287004770 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1168287004771 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287004772 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1168287004773 catalytic residue [active] 1168287004774 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1168287004775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004776 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1168287004777 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004778 Cytochrome P450; Region: p450; cl12078 1168287004779 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287004780 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004781 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287004782 acyl-activating enzyme (AAE) consensus motif; other site 1168287004783 acyl-activating enzyme (AAE) consensus motif; other site 1168287004784 putative AMP binding site [chemical binding]; other site 1168287004785 putative active site [active] 1168287004786 putative CoA binding site [chemical binding]; other site 1168287004787 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287004788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287004789 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287004790 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1168287004791 NAD(P) binding site [chemical binding]; other site 1168287004792 catalytic residues [active] 1168287004793 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287004794 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004795 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287004796 acyl-activating enzyme (AAE) consensus motif; other site 1168287004797 acyl-activating enzyme (AAE) consensus motif; other site 1168287004798 putative AMP binding site [chemical binding]; other site 1168287004799 putative active site [active] 1168287004800 putative CoA binding site [chemical binding]; other site 1168287004801 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287004802 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287004803 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287004804 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004805 Cytochrome P450; Region: p450; cl12078 1168287004806 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1168287004807 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168287004808 phosphate binding site [ion binding]; other site 1168287004809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287004810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004812 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1168287004813 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1168287004814 NAD binding site [chemical binding]; other site 1168287004815 homodimer interface [polypeptide binding]; other site 1168287004816 active site 1168287004817 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287004818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004819 acyl-activating enzyme (AAE) consensus motif; other site 1168287004820 AMP binding site [chemical binding]; other site 1168287004821 active site 1168287004822 CoA binding site [chemical binding]; other site 1168287004823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004825 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1168287004826 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1168287004827 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287004828 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004829 Cytochrome P450; Region: p450; cl12078 1168287004830 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1168287004831 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1168287004832 NAD binding site [chemical binding]; other site 1168287004833 catalytic Zn binding site [ion binding]; other site 1168287004834 substrate binding site [chemical binding]; other site 1168287004835 structural Zn binding site [ion binding]; other site 1168287004836 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004837 Cytochrome P450; Region: p450; cl12078 1168287004838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287004839 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287004840 active site 1168287004841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287004842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287004843 active site 1168287004844 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1168287004845 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1168287004846 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1168287004847 AMP-binding enzyme; Region: AMP-binding; pfam00501 1168287004848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004849 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287004850 acyl-activating enzyme (AAE) consensus motif; other site 1168287004851 putative AMP binding site [chemical binding]; other site 1168287004852 putative active site [active] 1168287004853 putative CoA binding site [chemical binding]; other site 1168287004854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004855 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1168287004856 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287004857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287004858 substrate binding site [chemical binding]; other site 1168287004859 oxyanion hole (OAH) forming residues; other site 1168287004860 trimer interface [polypeptide binding]; other site 1168287004861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004862 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1168287004863 NAD(P) binding site [chemical binding]; other site 1168287004864 active site 1168287004865 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004866 Cytochrome P450; Region: p450; cl12078 1168287004867 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1168287004868 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168287004869 phosphate binding site [ion binding]; other site 1168287004870 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1168287004871 NAD binding site [chemical binding]; other site 1168287004872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004874 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1168287004875 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1168287004876 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1168287004877 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1168287004878 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287004879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287004880 active site 1168287004881 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1168287004882 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287004883 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287004884 putative active site [active] 1168287004885 putative substrate binding site [chemical binding]; other site 1168287004886 ATP binding site [chemical binding]; other site 1168287004887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004889 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1168287004890 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287004891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287004892 Ecdysteroid kinase; Region: EcKinase; cl17738 1168287004893 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287004894 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1168287004895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287004896 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1168287004897 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1168287004898 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287004899 dimer interface [polypeptide binding]; other site 1168287004900 active site 1168287004901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287004902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287004903 active site 1168287004904 short chain dehydrogenase; Provisional; Region: PRK08251 1168287004905 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1168287004906 putative NAD(P) binding site [chemical binding]; other site 1168287004907 active site 1168287004908 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1168287004909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287004910 Walker A motif; other site 1168287004911 ATP binding site [chemical binding]; other site 1168287004912 Walker B motif; other site 1168287004913 Homeodomain-like domain; Region: HTH_23; pfam13384 1168287004914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1168287004915 Integrase core domain; Region: rve; pfam00665 1168287004916 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287004917 MULE transposase domain; Region: MULE; pfam10551 1168287004918 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287004919 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1168287004920 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1168287004921 integron integrase; Region: integrase_gron; TIGR02249 1168287004922 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1168287004923 active site 1168287004924 catalytic residues [active] 1168287004925 DNA binding site [nucleotide binding] 1168287004926 Int/Topo IB signature motif; other site 1168287004927 Homeodomain-like domain; Region: HTH_23; pfam13384 1168287004928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1168287004929 Integrase core domain; Region: rve; pfam00665 1168287004930 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1168287004931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287004932 Walker A motif; other site 1168287004933 ATP binding site [chemical binding]; other site 1168287004934 Walker B motif; other site 1168287004935 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1168287004936 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287004937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287004938 non-specific DNA binding site [nucleotide binding]; other site 1168287004939 salt bridge; other site 1168287004940 sequence-specific DNA binding site [nucleotide binding]; other site 1168287004941 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1168287004942 Caspase domain; Region: Peptidase_C14; pfam00656 1168287004943 Superfamily II helicase [General function prediction only]; Region: COG1204 1168287004944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287004945 ATP binding site [chemical binding]; other site 1168287004946 putative Mg++ binding site [ion binding]; other site 1168287004947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287004948 nucleotide binding region [chemical binding]; other site 1168287004949 ATP-binding site [chemical binding]; other site 1168287004950 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1168287004951 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1168287004952 NAD binding site [chemical binding]; other site 1168287004953 catalytic Zn binding site [ion binding]; other site 1168287004954 substrate binding site [chemical binding]; other site 1168287004955 structural Zn binding site [ion binding]; other site 1168287004956 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1168287004957 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1168287004958 NAD binding site [chemical binding]; other site 1168287004959 catalytic residues [active] 1168287004960 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168287004961 classical (c) SDRs; Region: SDR_c; cd05233 1168287004962 NAD(P) binding site [chemical binding]; other site 1168287004963 active site 1168287004964 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287004965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287004966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287004967 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1168287004968 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1168287004969 ligand binding site [chemical binding]; other site 1168287004970 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287004971 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287004972 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004973 Cytochrome P450; Region: p450; cl12078 1168287004974 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287004975 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287004976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287004977 NAD(P) binding site [chemical binding]; other site 1168287004978 active site 1168287004979 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1168287004980 classical (c) SDRs; Region: SDR_c; cd05233 1168287004981 NAD(P) binding site [chemical binding]; other site 1168287004982 active site 1168287004983 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287004984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287004985 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287004986 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004987 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287004988 acyl-activating enzyme (AAE) consensus motif; other site 1168287004989 acyl-activating enzyme (AAE) consensus motif; other site 1168287004990 AMP binding site [chemical binding]; other site 1168287004991 active site 1168287004992 CoA binding site [chemical binding]; other site 1168287004993 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287004994 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287004995 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287004996 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287004997 Cytochrome P450; Region: p450; cl12078 1168287004998 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168287004999 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287005000 NAD(P) binding site [chemical binding]; other site 1168287005001 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287005002 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287005003 active site 1168287005004 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1168287005005 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287005006 classical (c) SDRs; Region: SDR_c; cd05233 1168287005007 NAD(P) binding site [chemical binding]; other site 1168287005008 active site 1168287005009 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168287005010 classical (c) SDRs; Region: SDR_c; cd05233 1168287005011 NAD(P) binding site [chemical binding]; other site 1168287005012 active site 1168287005013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287005014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005016 lipid-transfer protein; Provisional; Region: PRK07855 1168287005017 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287005018 active site 1168287005019 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1168287005020 putative active site [active] 1168287005021 putative catalytic site [active] 1168287005022 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005023 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287005024 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287005025 active site 1168287005026 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1168287005027 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287005028 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287005029 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1168287005030 active site 1168287005031 catalytic site [active] 1168287005032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005033 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005034 active site 1168287005035 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287005036 Cytochrome P450; Region: p450; cl12078 1168287005037 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287005038 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1168287005039 NAD binding site [chemical binding]; other site 1168287005040 catalytic residues [active] 1168287005041 putative CoA-transferase; Provisional; Region: PRK11430 1168287005042 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287005043 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287005044 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287005045 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1168287005046 putative active site [active] 1168287005047 putative catalytic site [active] 1168287005048 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287005049 Isochorismatase family; Region: Isochorismatase; pfam00857 1168287005050 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1168287005051 catalytic triad [active] 1168287005052 conserved cis-peptide bond; other site 1168287005053 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287005054 SnoaL-like domain; Region: SnoaL_3; pfam13474 1168287005055 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287005056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287005057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005058 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287005059 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287005060 active site 1168287005061 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287005062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005063 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287005064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005065 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005066 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005067 active site 1168287005068 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1168287005069 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1168287005070 acyl-activating enzyme (AAE) consensus motif; other site 1168287005071 putative AMP binding site [chemical binding]; other site 1168287005072 putative active site [active] 1168287005073 putative CoA binding site [chemical binding]; other site 1168287005074 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287005075 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1168287005076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287005077 NAD(P) binding site [chemical binding]; other site 1168287005078 active site 1168287005079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287005080 active site 1168287005081 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287005082 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287005083 acyl-activating enzyme (AAE) consensus motif; other site 1168287005084 AMP binding site [chemical binding]; other site 1168287005085 active site 1168287005086 CoA binding site [chemical binding]; other site 1168287005087 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287005088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287005089 substrate binding site [chemical binding]; other site 1168287005090 oxyanion hole (OAH) forming residues; other site 1168287005091 trimer interface [polypeptide binding]; other site 1168287005092 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287005093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287005094 substrate binding site [chemical binding]; other site 1168287005095 oxyanion hole (OAH) forming residues; other site 1168287005096 trimer interface [polypeptide binding]; other site 1168287005097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005098 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005099 active site 1168287005100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287005101 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287005102 substrate binding site [chemical binding]; other site 1168287005103 oxyanion hole (OAH) forming residues; other site 1168287005104 trimer interface [polypeptide binding]; other site 1168287005105 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287005106 active site 2 [active] 1168287005107 active site 1 [active] 1168287005108 enoyl-CoA hydratase; Provisional; Region: PRK07799 1168287005109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287005110 substrate binding site [chemical binding]; other site 1168287005111 oxyanion hole (OAH) forming residues; other site 1168287005112 trimer interface [polypeptide binding]; other site 1168287005113 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1168287005114 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1168287005115 NAD binding site [chemical binding]; other site 1168287005116 homodimer interface [polypeptide binding]; other site 1168287005117 active site 1168287005118 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287005119 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287005120 acyl-activating enzyme (AAE) consensus motif; other site 1168287005121 AMP binding site [chemical binding]; other site 1168287005122 active site 1168287005123 CoA binding site [chemical binding]; other site 1168287005124 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287005125 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287005126 thiolase; Provisional; Region: PRK06158 1168287005127 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287005128 active site 1168287005129 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1168287005130 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1168287005131 active site 1168287005132 iron coordination sites [ion binding]; other site 1168287005133 substrate binding pocket [chemical binding]; other site 1168287005134 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1168287005135 glycerate dehydrogenase; Provisional; Region: PRK06487 1168287005136 ligand binding site [chemical binding]; other site 1168287005137 NAD binding site [chemical binding]; other site 1168287005138 dimerization interface [polypeptide binding]; other site 1168287005139 catalytic site [active] 1168287005140 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287005141 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287005142 substrate binding site [chemical binding]; other site 1168287005143 oxyanion hole (OAH) forming residues; other site 1168287005144 trimer interface [polypeptide binding]; other site 1168287005145 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287005146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005148 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005149 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005150 active site 1168287005151 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287005152 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005153 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005154 active site 1168287005155 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287005156 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168287005157 CoenzymeA binding site [chemical binding]; other site 1168287005158 subunit interaction site [polypeptide binding]; other site 1168287005159 PHB binding site; other site 1168287005160 enoyl-CoA hydratase; Provisional; Region: PRK08290 1168287005161 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287005162 substrate binding site [chemical binding]; other site 1168287005163 oxyanion hole (OAH) forming residues; other site 1168287005164 trimer interface [polypeptide binding]; other site 1168287005165 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287005166 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287005167 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1168287005168 FMN binding site [chemical binding]; other site 1168287005169 dimer interface [polypeptide binding]; other site 1168287005170 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287005171 Cytochrome P450; Region: p450; cl12078 1168287005172 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1168287005173 FMN binding site [chemical binding]; other site 1168287005174 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1168287005175 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287005176 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287005177 MarR family; Region: MarR_2; pfam12802 1168287005178 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168287005179 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287005180 Fe binding site [ion binding]; other site 1168287005181 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1168287005182 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287005183 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1168287005184 OsmC-like protein; Region: OsmC; cl00767 1168287005185 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1168287005186 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1168287005187 active site pocket [active] 1168287005188 aconitate hydratase; Validated; Region: PRK09277 1168287005189 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1168287005190 substrate binding site [chemical binding]; other site 1168287005191 ligand binding site [chemical binding]; other site 1168287005192 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1168287005193 substrate binding site [chemical binding]; other site 1168287005194 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1168287005195 dimer interface [polypeptide binding]; other site 1168287005196 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168287005197 HTH domain; Region: HTH_11; pfam08279 1168287005198 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1168287005199 heme-binding site [chemical binding]; other site 1168287005200 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1168287005201 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287005202 catalytic loop [active] 1168287005203 iron binding site [ion binding]; other site 1168287005204 Cupin domain; Region: Cupin_2; cl17218 1168287005205 Ferredoxin [Energy production and conversion]; Region: COG1146 1168287005206 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287005207 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1168287005208 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1168287005209 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1168287005210 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287005211 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1168287005212 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1168287005213 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1168287005214 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1168287005215 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1168287005216 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1168287005217 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1168287005218 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1168287005219 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1168287005220 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1168287005221 Binuclear center (active site) [active] 1168287005222 K-pathway; other site 1168287005223 Putative proton exit pathway; other site 1168287005224 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287005225 Fe binding site [ion binding]; other site 1168287005226 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287005227 PPE family; Region: PPE; pfam00823 1168287005228 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287005229 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168287005230 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1168287005231 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168287005232 Condensation domain; Region: Condensation; pfam00668 1168287005233 malate dehydrogenase; Provisional; Region: PRK13529 1168287005234 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1168287005235 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1168287005236 NAD(P) binding site [chemical binding]; other site 1168287005237 Flavodoxin; Region: Flavodoxin_1; pfam00258 1168287005238 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1168287005239 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1168287005240 FAD binding pocket [chemical binding]; other site 1168287005241 FAD binding motif [chemical binding]; other site 1168287005242 catalytic residues [active] 1168287005243 NAD binding pocket [chemical binding]; other site 1168287005244 phosphate binding motif [ion binding]; other site 1168287005245 beta-alpha-beta structure motif; other site 1168287005246 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1168287005247 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1168287005248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005250 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1168287005251 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1168287005252 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1168287005253 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1168287005254 acyl-activating enzyme (AAE) consensus motif; other site 1168287005255 active site 1168287005256 AMP binding site [chemical binding]; other site 1168287005257 substrate binding site [chemical binding]; other site 1168287005258 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1168287005259 Condensation domain; Region: Condensation; pfam00668 1168287005260 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287005261 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1168287005262 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1168287005263 acyl-activating enzyme (AAE) consensus motif; other site 1168287005264 AMP binding site [chemical binding]; other site 1168287005265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287005266 Thioesterase domain; Region: Thioesterase; pfam00975 1168287005267 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287005268 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1168287005269 active site 1168287005270 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168287005271 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287005272 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1168287005273 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287005274 NADP binding site [chemical binding]; other site 1168287005275 active site 1168287005276 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287005277 Condensation domain; Region: Condensation; pfam00668 1168287005278 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287005279 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287005280 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287005281 acyl-activating enzyme (AAE) consensus motif; other site 1168287005282 AMP binding site [chemical binding]; other site 1168287005283 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287005284 Condensation domain; Region: Condensation; pfam00668 1168287005285 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287005286 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287005287 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287005288 acyl-activating enzyme (AAE) consensus motif; other site 1168287005289 AMP binding site [chemical binding]; other site 1168287005290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287005291 Condensation domain; Region: Condensation; pfam00668 1168287005292 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287005293 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287005294 acyl-activating enzyme (AAE) consensus motif; other site 1168287005295 AMP binding site [chemical binding]; other site 1168287005296 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287005297 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1168287005298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287005299 MbtH-like protein; Region: MbtH; pfam03621 1168287005300 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1168287005301 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1168287005302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287005303 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287005304 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287005305 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1168287005306 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1168287005307 HTH domain; Region: HTH_11; cl17392 1168287005308 chaperone protein DnaJ; Provisional; Region: PRK14278 1168287005309 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1168287005310 HSP70 interaction site [polypeptide binding]; other site 1168287005311 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1168287005312 Zn binding sites [ion binding]; other site 1168287005313 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1168287005314 dimer interface [polypeptide binding]; other site 1168287005315 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1168287005316 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1168287005317 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1168287005318 PhoH-like protein; Region: PhoH; pfam02562 1168287005319 metal-binding heat shock protein; Provisional; Region: PRK00016 1168287005320 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1168287005321 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168287005322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168287005323 Transporter associated domain; Region: CorC_HlyC; smart01091 1168287005324 GTPase Era; Reviewed; Region: era; PRK00089 1168287005325 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1168287005326 G1 box; other site 1168287005327 GTP/Mg2+ binding site [chemical binding]; other site 1168287005328 Switch I region; other site 1168287005329 G2 box; other site 1168287005330 Switch II region; other site 1168287005331 G3 box; other site 1168287005332 G4 box; other site 1168287005333 G5 box; other site 1168287005334 KH domain; Region: KH_2; pfam07650 1168287005335 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1168287005336 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287005337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287005338 catalytic residue [active] 1168287005339 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1168287005340 amidase; Provisional; Region: PRK06061 1168287005341 Amidase; Region: Amidase; pfam01425 1168287005342 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1168287005343 Recombination protein O N terminal; Region: RecO_N; pfam11967 1168287005344 Recombination protein O C terminal; Region: RecO_C; pfam02565 1168287005345 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1168287005346 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1168287005347 catalytic residue [active] 1168287005348 putative FPP diphosphate binding site; other site 1168287005349 putative FPP binding hydrophobic cleft; other site 1168287005350 dimer interface [polypeptide binding]; other site 1168287005351 putative IPP diphosphate binding site; other site 1168287005352 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1168287005353 metal binding site 2 [ion binding]; metal-binding site 1168287005354 putative DNA binding helix; other site 1168287005355 metal binding site 1 [ion binding]; metal-binding site 1168287005356 dimer interface [polypeptide binding]; other site 1168287005357 structural Zn2+ binding site [ion binding]; other site 1168287005358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287005359 dimerization interface [polypeptide binding]; other site 1168287005360 putative DNA binding site [nucleotide binding]; other site 1168287005361 putative Zn2+ binding site [ion binding]; other site 1168287005362 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1168287005363 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168287005364 motif 1; other site 1168287005365 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1168287005366 active site 1168287005367 motif 2; other site 1168287005368 motif 3; other site 1168287005369 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1168287005370 anticodon binding site; other site 1168287005371 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287005372 PPE family; Region: PPE; pfam00823 1168287005373 Repair protein; Region: Repair_PSII; pfam04536 1168287005374 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1168287005375 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1168287005376 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1168287005377 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1168287005378 E-class dimer interface [polypeptide binding]; other site 1168287005379 P-class dimer interface [polypeptide binding]; other site 1168287005380 active site 1168287005381 Cu2+ binding site [ion binding]; other site 1168287005382 Zn2+ binding site [ion binding]; other site 1168287005383 DNA primase; Validated; Region: dnaG; PRK05667 1168287005384 CHC2 zinc finger; Region: zf-CHC2; cl17510 1168287005385 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1168287005386 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1168287005387 active site 1168287005388 metal binding site [ion binding]; metal-binding site 1168287005389 interdomain interaction site; other site 1168287005390 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1168287005391 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1168287005392 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1168287005393 active site 1168287005394 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1168287005395 non-prolyl cis peptide bond; other site 1168287005396 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1168287005397 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1168287005398 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287005399 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1168287005400 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1168287005401 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1168287005402 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1168287005403 trimer interface [polypeptide binding]; other site 1168287005404 active site 1168287005405 substrate binding site [chemical binding]; other site 1168287005406 CoA binding site [chemical binding]; other site 1168287005407 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168287005408 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168287005409 dimer interface [polypeptide binding]; other site 1168287005410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287005411 catalytic residue [active] 1168287005412 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1168287005413 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1168287005414 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1168287005415 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1168287005416 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1168287005417 [4Fe-4S] binding site [ion binding]; other site 1168287005418 molybdopterin cofactor binding site; other site 1168287005419 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1168287005420 molybdopterin cofactor binding site; other site 1168287005421 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1168287005422 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1168287005423 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1168287005424 FAD binding pocket [chemical binding]; other site 1168287005425 FAD binding motif [chemical binding]; other site 1168287005426 catalytic residues [active] 1168287005427 NAD binding pocket [chemical binding]; other site 1168287005428 phosphate binding motif [ion binding]; other site 1168287005429 beta-alpha-beta structure motif; other site 1168287005430 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1168287005431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005432 active site 1168287005433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287005434 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1168287005435 Walker A/P-loop; other site 1168287005436 ATP binding site [chemical binding]; other site 1168287005437 Q-loop/lid; other site 1168287005438 ABC transporter signature motif; other site 1168287005439 Walker B; other site 1168287005440 D-loop; other site 1168287005441 H-loop/switch region; other site 1168287005442 MarR family; Region: MarR; pfam01047 1168287005443 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287005444 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 1168287005445 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644 1168287005446 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168287005447 Walker A/P-loop; other site 1168287005448 ATP binding site [chemical binding]; other site 1168287005449 Q-loop/lid; other site 1168287005450 ABC transporter signature motif; other site 1168287005451 Walker B; other site 1168287005452 D-loop; other site 1168287005453 H-loop/switch region; other site 1168287005454 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168287005455 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168287005456 Walker A/P-loop; other site 1168287005457 ATP binding site [chemical binding]; other site 1168287005458 Q-loop/lid; other site 1168287005459 ABC transporter signature motif; other site 1168287005460 Walker B; other site 1168287005461 D-loop; other site 1168287005462 H-loop/switch region; other site 1168287005463 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1168287005464 amino acid transporter; Region: 2A0306; TIGR00909 1168287005465 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1168287005466 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1168287005467 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168287005468 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168287005469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287005470 dimer interface [polypeptide binding]; other site 1168287005471 conserved gate region; other site 1168287005472 putative PBP binding loops; other site 1168287005473 ABC-ATPase subunit interface; other site 1168287005474 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1168287005475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287005476 dimer interface [polypeptide binding]; other site 1168287005477 conserved gate region; other site 1168287005478 putative PBP binding loops; other site 1168287005479 ABC-ATPase subunit interface; other site 1168287005480 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1168287005481 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1168287005482 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287005483 Helix-turn-helix domain; Region: HTH_28; pfam13518 1168287005484 Winged helix-turn helix; Region: HTH_29; pfam13551 1168287005485 Homeodomain-like domain; Region: HTH_32; pfam13565 1168287005486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1168287005487 Integrase core domain; Region: rve; pfam00665 1168287005488 Integrase core domain; Region: rve_3; pfam13683 1168287005489 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287005490 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168287005491 catalytic site [active] 1168287005492 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1168287005493 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168287005494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287005495 ABC transporter signature motif; other site 1168287005496 Walker B; other site 1168287005497 D-loop; other site 1168287005498 H-loop/switch region; other site 1168287005499 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1168287005500 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287005501 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287005502 NAD(P) binding site [chemical binding]; other site 1168287005503 catalytic residues [active] 1168287005504 Repair protein; Region: Repair_PSII; pfam04536 1168287005505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1168287005506 AAA domain; Region: AAA_33; pfam13671 1168287005507 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1168287005508 active site 1168287005509 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1168287005510 catalytic triad [active] 1168287005511 active site nucleophile [active] 1168287005512 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1168287005513 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1168287005514 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287005515 cyclase homology domain; Region: CHD; cd07302 1168287005516 nucleotidyl binding site; other site 1168287005517 metal binding site [ion binding]; metal-binding site 1168287005518 dimer interface [polypeptide binding]; other site 1168287005519 Predicted ATPase [General function prediction only]; Region: COG3899 1168287005520 AAA ATPase domain; Region: AAA_16; pfam13191 1168287005521 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1168287005522 GAF domain; Region: GAF; pfam01590 1168287005523 GAF domain; Region: GAF_3; pfam13492 1168287005524 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1168287005525 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1168287005526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1168287005527 ATP binding site [chemical binding]; other site 1168287005528 Mg2+ binding site [ion binding]; other site 1168287005529 G-X-G motif; other site 1168287005530 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287005531 anti sigma factor interaction site; other site 1168287005532 regulatory phosphorylation site [posttranslational modification]; other site 1168287005533 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1168287005534 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287005535 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287005536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287005537 S-adenosylmethionine binding site [chemical binding]; other site 1168287005538 CCC1-related family of proteins; Region: CCC1_like; cl00278 1168287005539 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287005540 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168287005541 active site 2 [active] 1168287005542 active site 1 [active] 1168287005543 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287005544 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1168287005545 acyl-activating enzyme (AAE) consensus motif; other site 1168287005546 putative AMP binding site [chemical binding]; other site 1168287005547 putative active site [active] 1168287005548 putative CoA binding site [chemical binding]; other site 1168287005549 TIGR03085 family protein; Region: TIGR03085 1168287005550 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1168287005551 heat shock protein 90; Provisional; Region: PRK05218 1168287005552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287005553 ATP binding site [chemical binding]; other site 1168287005554 Mg2+ binding site [ion binding]; other site 1168287005555 G-X-G motif; other site 1168287005556 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287005557 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287005558 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287005559 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1168287005560 dimer interface [polypeptide binding]; other site 1168287005561 ligand binding site [chemical binding]; other site 1168287005562 Predicted membrane protein [Function unknown]; Region: COG4270 1168287005563 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1168287005564 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1168287005565 NAD binding site [chemical binding]; other site 1168287005566 catalytic Zn binding site [ion binding]; other site 1168287005567 substrate binding site [chemical binding]; other site 1168287005568 structural Zn binding site [ion binding]; other site 1168287005569 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287005570 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1168287005571 dimer interface [polypeptide binding]; other site 1168287005572 active site 1168287005573 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168287005574 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1168287005575 active site 1168287005576 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1168287005577 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1168287005578 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1168287005579 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1168287005580 MarR family; Region: MarR; pfam01047 1168287005581 haloalkane dehalogenase; Provisional; Region: PRK00870 1168287005582 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1168287005583 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1168287005584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287005585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287005586 homodimer interface [polypeptide binding]; other site 1168287005587 catalytic residue [active] 1168287005588 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287005589 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1168287005590 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287005591 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287005592 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1168287005593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005595 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287005596 Cytochrome P450; Region: p450; cl12078 1168287005597 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287005598 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287005599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287005600 dimerization interface [polypeptide binding]; other site 1168287005601 putative DNA binding site [nucleotide binding]; other site 1168287005602 putative Zn2+ binding site [ion binding]; other site 1168287005603 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1168287005604 arsenical-resistance protein; Region: acr3; TIGR00832 1168287005605 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1168287005606 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1168287005607 active site 1168287005608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1168287005609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287005610 putative metal binding site [ion binding]; other site 1168287005611 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287005612 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1168287005613 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1168287005614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005615 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287005616 Cytochrome P450; Region: p450; cl12078 1168287005617 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1168287005618 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1168287005619 active site residue [active] 1168287005620 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1168287005621 active site residue [active] 1168287005622 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287005623 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1168287005624 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168287005625 hypothetical protein; Provisional; Region: PRK08244 1168287005626 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287005627 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287005628 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287005629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005630 Predicted ATPase [General function prediction only]; Region: COG4637 1168287005631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287005632 Walker A/P-loop; other site 1168287005633 ATP binding site [chemical binding]; other site 1168287005634 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1168287005635 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1168287005636 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1168287005637 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287005638 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287005639 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1168287005640 4Fe-4S binding domain; Region: Fer4; cl02805 1168287005641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168287005642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287005643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1168287005644 dimerization interface [polypeptide binding]; other site 1168287005645 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1168287005646 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1168287005647 putative active site [active] 1168287005648 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1168287005649 putative active site [active] 1168287005650 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1168287005651 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1168287005652 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1168287005653 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1168287005654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287005655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287005656 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287005657 Cytochrome P450; Region: p450; cl12078 1168287005658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005662 Domain of unknown function (DUF385); Region: DUF385; cl04387 1168287005663 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287005664 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287005665 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287005666 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1168287005667 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287005668 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287005669 active site 1168287005670 ATP binding site [chemical binding]; other site 1168287005671 substrate binding site [chemical binding]; other site 1168287005672 activation loop (A-loop); other site 1168287005673 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1168287005674 2TM domain; Region: 2TM; pfam13239 1168287005675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005677 WHG domain; Region: WHG; pfam13305 1168287005678 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287005679 Cytochrome P450; Region: p450; cl12078 1168287005680 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168287005681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287005682 active site 1168287005683 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287005684 MULE transposase domain; Region: MULE; pfam10551 1168287005685 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1168287005686 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1168287005687 DNA methylase; Region: N6_N4_Mtase; cl17433 1168287005688 DNA methylase; Region: N6_N4_Mtase; pfam01555 1168287005689 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168287005690 Part of AAA domain; Region: AAA_19; pfam13245 1168287005691 Family description; Region: UvrD_C_2; pfam13538 1168287005692 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1168287005693 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1168287005694 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168287005695 helix-hairpin-helix signature motif; other site 1168287005696 substrate binding pocket [chemical binding]; other site 1168287005697 active site 1168287005698 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1168287005699 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1168287005700 Part of AAA domain; Region: AAA_19; pfam13245 1168287005701 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1168287005702 AAA domain; Region: AAA_12; pfam13087 1168287005703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287005704 AAA domain; Region: AAA_23; pfam13476 1168287005705 Walker A/P-loop; other site 1168287005706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287005707 ABC transporter signature motif; other site 1168287005708 Walker B; other site 1168287005709 D-loop; other site 1168287005710 H-loop/switch region; other site 1168287005711 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1168287005712 putative catalytic site [active] 1168287005713 putative phosphate binding site [ion binding]; other site 1168287005714 putative metal binding site [ion binding]; other site 1168287005715 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287005716 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287005717 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287005718 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287005719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005721 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287005722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287005723 active site 1168287005724 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1168287005725 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1168287005726 active site 1168287005727 metal binding site [ion binding]; metal-binding site 1168287005728 Cutinase; Region: Cutinase; pfam01083 1168287005729 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287005730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287005731 Septum formation; Region: Septum_form; pfam13845 1168287005732 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287005733 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287005734 Cytochrome P450; Region: p450; cl12078 1168287005735 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287005736 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287005737 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287005738 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287005739 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1168287005740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287005741 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1168287005742 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1168287005743 NAD binding site [chemical binding]; other site 1168287005744 catalytic Zn binding site [ion binding]; other site 1168287005745 substrate binding site [chemical binding]; other site 1168287005746 structural Zn binding site [ion binding]; other site 1168287005747 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287005748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287005749 S-adenosylmethionine binding site [chemical binding]; other site 1168287005750 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287005751 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287005752 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1168287005753 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287005754 diacylglycerol kinase; Reviewed; Region: PRK11914 1168287005755 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1168287005756 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168287005757 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287005758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287005759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287005760 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1168287005761 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1168287005762 nucleoside/Zn binding site; other site 1168287005763 dimer interface [polypeptide binding]; other site 1168287005764 catalytic motif [active] 1168287005765 hypothetical protein; Provisional; Region: PRK06126 1168287005766 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287005767 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168287005768 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168287005769 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287005770 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1168287005771 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1168287005772 dimer interface [polypeptide binding]; other site 1168287005773 active site 1168287005774 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1168287005775 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1168287005776 dimer interface [polypeptide binding]; other site 1168287005777 active site 1168287005778 acyl carrier protein; Provisional; Region: acpP; PRK00982 1168287005779 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1168287005780 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168287005781 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1168287005782 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1168287005783 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1168287005784 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1168287005785 dimer interface [polypeptide binding]; other site 1168287005786 TPP-binding site [chemical binding]; other site 1168287005787 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1168287005788 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1168287005789 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1168287005790 dimer interface [polypeptide binding]; other site 1168287005791 catalytic triad [active] 1168287005792 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1168287005793 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1168287005794 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287005795 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287005796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287005797 active site 1168287005798 metal binding site [ion binding]; metal-binding site 1168287005799 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1168287005800 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1168287005801 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1168287005802 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1168287005803 active site 1168287005804 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1168287005805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287005806 motif II; other site 1168287005807 hypothetical protein; Provisional; Region: PRK07908 1168287005808 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287005809 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287005810 catalytic residue [active] 1168287005811 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1168287005812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1168287005813 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1168287005814 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1168287005815 Putative zinc ribbon domain; Region: DUF164; pfam02591 1168287005816 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1168287005817 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1168287005818 RNA/DNA hybrid binding site [nucleotide binding]; other site 1168287005819 active site 1168287005820 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287005821 catalytic core [active] 1168287005822 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1168287005823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287005824 Helix-turn-helix domain; Region: HTH_18; pfam12833 1168287005825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287005826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287005827 sequence-specific DNA binding site [nucleotide binding]; other site 1168287005828 salt bridge; other site 1168287005829 Cupin domain; Region: Cupin_2; pfam07883 1168287005830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287005831 S-adenosylmethionine binding site [chemical binding]; other site 1168287005832 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1168287005833 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1168287005834 putative active site; other site 1168287005835 putative metal binding residues [ion binding]; other site 1168287005836 signature motif; other site 1168287005837 putative triphosphate binding site [ion binding]; other site 1168287005838 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1168287005839 hypothetical protein; Provisional; Region: PRK06185 1168287005840 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1168287005841 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1168287005842 oligomerization interface [polypeptide binding]; other site 1168287005843 active site 1168287005844 metal binding site [ion binding]; metal-binding site 1168287005845 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1168287005846 TAP-like protein; Region: Abhydrolase_4; pfam08386 1168287005847 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1168287005848 TAP-like protein; Region: Abhydrolase_4; pfam08386 1168287005849 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1168287005850 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1168287005851 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168287005852 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1168287005853 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168287005854 metal binding triad; other site 1168287005855 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168287005856 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168287005857 metal binding triad; other site 1168287005858 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168287005859 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287005860 CoenzymeA binding site [chemical binding]; other site 1168287005861 subunit interaction site [polypeptide binding]; other site 1168287005862 PHB binding site; other site 1168287005863 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287005864 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287005865 MarR family; Region: MarR_2; pfam12802 1168287005866 potential frameshift: common BLAST hit: gi|379761563|ref|YP_005347960.1| putative flavin reductase 1168287005867 Fic/DOC family; Region: Fic; pfam02661 1168287005868 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1168287005869 D5 N terminal like; Region: D5_N; pfam08706 1168287005870 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1168287005871 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1168287005872 polymerase nucleotide-binding site; other site 1168287005873 DNA-binding residues [nucleotide binding]; DNA binding site 1168287005874 nucleotide binding site [chemical binding]; other site 1168287005875 primase nucleotide-binding site [nucleotide binding]; other site 1168287005876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287005877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287005878 non-specific DNA binding site [nucleotide binding]; other site 1168287005879 salt bridge; other site 1168287005880 sequence-specific DNA binding site [nucleotide binding]; other site 1168287005881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168287005882 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1168287005883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168287005884 active site 1168287005885 DNA binding site [nucleotide binding] 1168287005886 Int/Topo IB signature motif; other site 1168287005887 glutamine synthetase, type I; Region: GlnA; TIGR00653 1168287005888 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1168287005889 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168287005890 RDD family; Region: RDD; pfam06271 1168287005891 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1168287005892 lipoyl synthase; Provisional; Region: PRK05481 1168287005893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287005894 FeS/SAM binding site; other site 1168287005895 lipoate-protein ligase B; Provisional; Region: PRK14345 1168287005896 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1168287005897 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1168287005898 putative NAD(P) binding site [chemical binding]; other site 1168287005899 putative active site [active] 1168287005900 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168287005901 E3 interaction surface; other site 1168287005902 lipoyl attachment site [posttranslational modification]; other site 1168287005903 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168287005904 E3 interaction surface; other site 1168287005905 lipoyl attachment site [posttranslational modification]; other site 1168287005906 e3 binding domain; Region: E3_binding; pfam02817 1168287005907 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1168287005908 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1168287005909 short chain dehydrogenase; Validated; Region: PRK05855 1168287005910 classical (c) SDRs; Region: SDR_c; cd05233 1168287005911 NAD(P) binding site [chemical binding]; other site 1168287005912 active site 1168287005913 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287005914 hydrophobic ligand binding site; other site 1168287005915 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287005916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287005917 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1168287005918 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1168287005919 interface (dimer of trimers) [polypeptide binding]; other site 1168287005920 Substrate-binding/catalytic site; other site 1168287005921 Zn-binding sites [ion binding]; other site 1168287005922 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1168287005923 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1168287005924 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1168287005925 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1168287005926 homodimer interface [polypeptide binding]; other site 1168287005927 substrate-cofactor binding pocket; other site 1168287005928 catalytic residue [active] 1168287005929 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1168287005930 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1168287005931 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1168287005932 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1168287005933 putative dimer interface [polypeptide binding]; other site 1168287005934 active site pocket [active] 1168287005935 putative cataytic base [active] 1168287005936 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1168287005937 homotrimer interface [polypeptide binding]; other site 1168287005938 Walker A motif; other site 1168287005939 GTP binding site [chemical binding]; other site 1168287005940 Walker B motif; other site 1168287005941 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1168287005942 Glycerate kinase family; Region: Gly_kinase; pfam02595 1168287005943 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1168287005944 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1168287005945 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168287005946 substrate binding site [chemical binding]; other site 1168287005947 ATP binding site [chemical binding]; other site 1168287005948 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1168287005949 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1168287005950 active site 1168287005951 dimer interface [polypeptide binding]; other site 1168287005952 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1168287005953 Ligand Binding Site [chemical binding]; other site 1168287005954 Molecular Tunnel; other site 1168287005955 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1168287005956 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1168287005957 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1168287005958 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287005959 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1168287005960 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1168287005961 heme bH binding site [chemical binding]; other site 1168287005962 intrachain domain interface; other site 1168287005963 heme bL binding site [chemical binding]; other site 1168287005964 interchain domain interface [polypeptide binding]; other site 1168287005965 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1168287005966 Qo binding site; other site 1168287005967 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1168287005968 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1168287005969 iron-sulfur cluster [ion binding]; other site 1168287005970 [2Fe-2S] cluster binding site [ion binding]; other site 1168287005971 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1168287005972 Cytochrome c; Region: Cytochrom_C; pfam00034 1168287005973 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1168287005974 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1168287005975 Subunit I/III interface [polypeptide binding]; other site 1168287005976 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1168287005977 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1168287005978 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1168287005979 hypothetical protein; Validated; Region: PRK07883 1168287005980 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1168287005981 active site 1168287005982 catalytic site [active] 1168287005983 substrate binding site [chemical binding]; other site 1168287005984 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1168287005985 GIY-YIG motif/motif A; other site 1168287005986 active site 1168287005987 catalytic site [active] 1168287005988 putative DNA binding site [nucleotide binding]; other site 1168287005989 metal binding site [ion binding]; metal-binding site 1168287005990 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168287005991 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168287005992 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1168287005993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287005994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287005995 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168287005996 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1168287005997 acyl-activating enzyme (AAE) consensus motif; other site 1168287005998 putative AMP binding site [chemical binding]; other site 1168287005999 putative active site [active] 1168287006000 putative CoA binding site [chemical binding]; other site 1168287006001 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1168287006002 putative hydrophobic ligand binding site [chemical binding]; other site 1168287006003 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1168287006004 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1168287006005 DTAP/Switch II; other site 1168287006006 Switch I; other site 1168287006007 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287006008 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168287006009 putative acyl-acceptor binding pocket; other site 1168287006010 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1168287006011 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1168287006012 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287006013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287006014 active site 1168287006015 ATP binding site [chemical binding]; other site 1168287006016 substrate binding site [chemical binding]; other site 1168287006017 activation loop (A-loop); other site 1168287006018 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1168287006019 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1168287006020 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1168287006021 substrate binding pocket [chemical binding]; other site 1168287006022 chain length determination region; other site 1168287006023 substrate-Mg2+ binding site; other site 1168287006024 catalytic residues [active] 1168287006025 aspartate-rich region 1; other site 1168287006026 active site lid residues [active] 1168287006027 aspartate-rich region 2; other site 1168287006028 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1168287006029 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1168287006030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1168287006031 MraZ protein; Region: MraZ; pfam02381 1168287006032 MraZ protein; Region: MraZ; pfam02381 1168287006033 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1168287006034 MraW methylase family; Region: Methyltransf_5; cl17771 1168287006035 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1168287006036 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1168287006037 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168287006038 hypothetical protein; Provisional; Region: PRK07236 1168287006039 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287006040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006042 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1168287006043 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168287006044 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168287006045 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168287006046 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1168287006047 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168287006048 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168287006049 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1168287006050 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1168287006051 Mg++ binding site [ion binding]; other site 1168287006052 putative catalytic motif [active] 1168287006053 putative substrate binding site [chemical binding]; other site 1168287006054 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1168287006055 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168287006056 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168287006057 cell division protein FtsW; Region: ftsW; TIGR02614 1168287006058 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1168287006059 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1168287006060 active site 1168287006061 homodimer interface [polypeptide binding]; other site 1168287006062 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1168287006063 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168287006064 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168287006065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168287006066 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1168287006067 Cell division protein FtsQ; Region: FtsQ; pfam03799 1168287006068 cell division protein FtsZ; Validated; Region: PRK09330 1168287006069 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1168287006070 nucleotide binding site [chemical binding]; other site 1168287006071 SulA interaction site; other site 1168287006072 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1168287006073 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1168287006074 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1168287006075 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168287006076 catalytic residue [active] 1168287006077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1168287006078 Predicted integral membrane protein [Function unknown]; Region: COG0762 1168287006079 DivIVA domain; Region: DivI1A_domain; TIGR03544 1168287006080 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1168287006081 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1168287006082 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168287006083 active site 1168287006084 Divergent AAA domain; Region: AAA_4; pfam04326 1168287006085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287006086 non-specific DNA binding site [nucleotide binding]; other site 1168287006087 salt bridge; other site 1168287006088 sequence-specific DNA binding site [nucleotide binding]; other site 1168287006089 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1168287006090 putative active site [active] 1168287006091 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1168287006092 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287006093 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287006094 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287006095 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 1168287006096 NAD(P) binding site [chemical binding]; other site 1168287006097 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1168287006098 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287006099 active site 1168287006100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006102 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287006103 CoenzymeA binding site [chemical binding]; other site 1168287006104 subunit interaction site [polypeptide binding]; other site 1168287006105 PHB binding site; other site 1168287006106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287006107 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287006108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006110 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168287006111 potential frameshift: common BLAST hit: gi|379009193|ref|YP_005266955.1| transposase mutator type 1168287006112 potential frameshift: common BLAST hit: gi|111025371|ref|YP_707791.1| transposase 1168287006113 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287006114 MULE transposase domain; Region: MULE; pfam10551 1168287006115 Winged helix-turn helix; Region: HTH_29; pfam13551 1168287006116 Homeodomain-like domain; Region: HTH_32; pfam13565 1168287006117 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1168287006118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1168287006119 short chain dehydrogenase; Provisional; Region: PRK07832 1168287006120 classical (c) SDRs; Region: SDR_c; cd05233 1168287006121 NAD(P) binding site [chemical binding]; other site 1168287006122 active site 1168287006123 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287006124 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287006125 MULE transposase domain; Region: MULE; pfam10551 1168287006126 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1168287006127 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1168287006128 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1168287006129 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168287006130 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1168287006131 potential frameshift: common BLAST hit: gi|145223610|ref|YP_001134288.1| transposase, mutator type 1168287006132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006134 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168287006135 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287006136 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168287006137 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1168287006138 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1168287006139 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1168287006140 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1168287006141 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287006142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287006143 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287006144 MULE transposase domain; Region: MULE; pfam10551 1168287006145 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287006146 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1168287006147 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1168287006148 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287006149 Permease; Region: Permease; pfam02405 1168287006150 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287006151 Permease; Region: Permease; pfam02405 1168287006152 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287006153 mce related protein; Region: MCE; pfam02470 1168287006154 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287006155 mce related protein; Region: MCE; pfam02470 1168287006156 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287006157 mce related protein; Region: MCE; pfam02470 1168287006158 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1168287006159 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287006160 mce related protein; Region: MCE; pfam02470 1168287006161 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287006162 mce related protein; Region: MCE; pfam02470 1168287006163 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287006164 mce related protein; Region: MCE; pfam02470 1168287006165 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1168287006166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006168 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287006169 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168287006170 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1168287006171 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287006172 MULE transposase domain; Region: MULE; pfam10551 1168287006173 Helix-turn-helix domain; Region: HTH_28; pfam13518 1168287006174 Winged helix-turn helix; Region: HTH_29; pfam13551 1168287006175 Homeodomain-like domain; Region: HTH_32; pfam13565 1168287006176 Integrase core domain; Region: rve; pfam00665 1168287006177 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287006178 MULE transposase domain; Region: MULE; pfam10551 1168287006179 Integrase core domain; Region: rve; pfam00665 1168287006180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1168287006181 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1168287006182 AAA domain; Region: AAA_22; pfam13401 1168287006183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006185 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1168287006186 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1168287006187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006189 classical (c) SDRs; Region: SDR_c; cd05233 1168287006190 short chain dehydrogenase; Provisional; Region: PRK05650 1168287006191 NAD(P) binding site [chemical binding]; other site 1168287006192 active site 1168287006193 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287006194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287006195 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287006196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287006197 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287006198 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287006199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287006200 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1168287006201 Cytochrome P450; Region: p450; cl12078 1168287006202 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1168287006203 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1168287006204 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1168287006205 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287006206 acyl-activating enzyme (AAE) consensus motif; other site 1168287006207 AMP binding site [chemical binding]; other site 1168287006208 active site 1168287006209 CoA binding site [chemical binding]; other site 1168287006210 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287006211 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287006212 active site 1168287006213 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1168287006214 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1168287006215 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1168287006216 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1168287006217 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287006218 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1168287006219 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1168287006220 catalytic residues [active] 1168287006221 catalytic nucleophile [active] 1168287006222 Recombinase; Region: Recombinase; pfam07508 1168287006223 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1168287006224 hypothetical protein; Provisional; Region: PRK07906 1168287006225 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1168287006226 putative metal binding site [ion binding]; other site 1168287006227 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1168287006228 substrate binding site [chemical binding]; other site 1168287006229 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1168287006230 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1168287006231 quinone interaction residues [chemical binding]; other site 1168287006232 active site 1168287006233 catalytic residues [active] 1168287006234 FMN binding site [chemical binding]; other site 1168287006235 substrate binding site [chemical binding]; other site 1168287006236 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287006237 catalytic core [active] 1168287006238 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1168287006239 conserved hypothetical protein; Region: TIGR03843 1168287006240 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1168287006241 active site 1168287006242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287006243 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1168287006244 active site 1168287006245 HIGH motif; other site 1168287006246 nucleotide binding site [chemical binding]; other site 1168287006247 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287006248 active site 1168287006249 KMSKS motif; other site 1168287006250 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1168287006251 putative tRNA binding surface [nucleotide binding]; other site 1168287006252 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287006253 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287006254 DNA binding residues [nucleotide binding] 1168287006255 dimerization interface [polypeptide binding]; other site 1168287006256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287006257 Walker A/P-loop; other site 1168287006258 ATP binding site [chemical binding]; other site 1168287006259 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287006260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287006261 DNA binding residues [nucleotide binding] 1168287006262 dimerization interface [polypeptide binding]; other site 1168287006263 MbtH-like protein; Region: MbtH; pfam03621 1168287006264 Condensation domain; Region: Condensation; pfam00668 1168287006265 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287006266 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287006267 acyl-activating enzyme (AAE) consensus motif; other site 1168287006268 AMP binding site [chemical binding]; other site 1168287006269 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287006270 Condensation domain; Region: Condensation; pfam00668 1168287006271 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287006272 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287006273 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287006274 acyl-activating enzyme (AAE) consensus motif; other site 1168287006275 AMP binding site [chemical binding]; other site 1168287006276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287006277 Condensation domain; Region: Condensation; pfam00668 1168287006278 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287006279 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287006280 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287006281 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287006282 acyl-activating enzyme (AAE) consensus motif; other site 1168287006283 AMP binding site [chemical binding]; other site 1168287006284 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1168287006285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287006286 S-adenosylmethionine binding site [chemical binding]; other site 1168287006287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287006288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287006289 Condensation domain; Region: Condensation; pfam00668 1168287006290 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287006291 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287006292 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287006293 acyl-activating enzyme (AAE) consensus motif; other site 1168287006294 AMP binding site [chemical binding]; other site 1168287006295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287006296 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1168287006297 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287006298 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287006299 acyl-activating enzyme (AAE) consensus motif; other site 1168287006300 AMP binding site [chemical binding]; other site 1168287006301 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287006302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287006303 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1168287006304 putative substrate translocation pore; other site 1168287006305 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168287006306 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287006307 active site 1168287006308 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1168287006309 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1168287006310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006311 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1168287006312 Enoylreductase; Region: PKS_ER; smart00829 1168287006313 NAD(P) binding site [chemical binding]; other site 1168287006314 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1168287006315 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287006316 putative NADP binding site [chemical binding]; other site 1168287006317 active site 1168287006318 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287006319 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287006320 Cytochrome P450; Region: p450; cl12078 1168287006321 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1168287006322 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1168287006323 FAD binding pocket [chemical binding]; other site 1168287006324 FAD binding motif [chemical binding]; other site 1168287006325 phosphate binding motif [ion binding]; other site 1168287006326 NAD binding pocket [chemical binding]; other site 1168287006327 acyl-CoA synthetase; Validated; Region: PRK05850 1168287006328 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1168287006329 acyl-activating enzyme (AAE) consensus motif; other site 1168287006330 active site 1168287006331 short chain dehydrogenase; Provisional; Region: PRK05872 1168287006332 classical (c) SDRs; Region: SDR_c; cd05233 1168287006333 NAD(P) binding site [chemical binding]; other site 1168287006334 active site 1168287006335 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1168287006336 PAC2 family; Region: PAC2; pfam09754 1168287006337 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1168287006338 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1168287006339 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1168287006340 substrate binding pocket [chemical binding]; other site 1168287006341 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1168287006342 B12 binding site [chemical binding]; other site 1168287006343 cobalt ligand [ion binding]; other site 1168287006344 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1168287006345 Mannan-binding protein; Region: MVL; pfam12151 1168287006346 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1168287006347 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287006348 mce related protein; Region: MCE; pfam02470 1168287006349 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287006350 mce related protein; Region: MCE; pfam02470 1168287006351 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287006352 mce related protein; Region: MCE; pfam02470 1168287006353 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1168287006354 mce related protein; Region: MCE; pfam02470 1168287006355 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1168287006356 mce related protein; Region: MCE; pfam02470 1168287006357 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287006358 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287006359 Permease; Region: Permease; pfam02405 1168287006360 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287006361 Permease; Region: Permease; pfam02405 1168287006362 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287006363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006364 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1168287006365 homodimer interface [polypeptide binding]; other site 1168287006366 putative metal binding site [ion binding]; other site 1168287006367 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1168287006368 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1168287006369 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1168287006370 Predicted membrane protein [Function unknown]; Region: COG3918 1168287006371 mercuric reductase; Validated; Region: PRK06370 1168287006372 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287006373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287006374 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287006375 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1168287006376 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1168287006377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287006378 S-adenosylmethionine binding site [chemical binding]; other site 1168287006379 Protein of unknown function (DUF503); Region: DUF503; cl00669 1168287006380 proteasome ATPase; Region: pup_AAA; TIGR03689 1168287006381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287006382 Walker A motif; other site 1168287006383 ATP binding site [chemical binding]; other site 1168287006384 Walker B motif; other site 1168287006385 arginine finger; other site 1168287006386 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1168287006387 Pup-like protein; Region: Pup; cl05289 1168287006388 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1168287006389 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1168287006390 active site 1168287006391 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1168287006392 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1168287006393 active site 1168287006394 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1168287006395 Predicted transcriptional regulator [Transcription]; Region: COG2378 1168287006396 WYL domain; Region: WYL; pfam13280 1168287006397 Predicted transcriptional regulator [Transcription]; Region: COG2378 1168287006398 WYL domain; Region: WYL; pfam13280 1168287006399 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1168287006400 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1168287006401 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1168287006402 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1168287006403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287006404 ATP binding site [chemical binding]; other site 1168287006405 putative Mg++ binding site [ion binding]; other site 1168287006406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287006407 nucleotide binding region [chemical binding]; other site 1168287006408 ATP-binding site [chemical binding]; other site 1168287006409 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1168287006410 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1168287006411 5'-3' exonuclease; Region: 53EXOc; smart00475 1168287006412 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1168287006413 active site 1168287006414 metal binding site 1 [ion binding]; metal-binding site 1168287006415 putative 5' ssDNA interaction site; other site 1168287006416 metal binding site 3; metal-binding site 1168287006417 metal binding site 2 [ion binding]; metal-binding site 1168287006418 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1168287006419 putative DNA binding site [nucleotide binding]; other site 1168287006420 putative metal binding site [ion binding]; other site 1168287006421 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168287006422 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1168287006423 active site 1168287006424 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1168287006425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006426 NAD(P) binding site [chemical binding]; other site 1168287006427 active site 1168287006428 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1168287006429 active site 1168287006430 putative homodimer interface [polypeptide binding]; other site 1168287006431 SAM binding site [chemical binding]; other site 1168287006432 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1168287006433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287006434 S-adenosylmethionine binding site [chemical binding]; other site 1168287006435 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1168287006436 active site 1168287006437 SAM binding site [chemical binding]; other site 1168287006438 homodimer interface [polypeptide binding]; other site 1168287006439 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1168287006440 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1168287006441 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 1168287006442 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1168287006443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287006444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287006445 DNA binding residues [nucleotide binding] 1168287006446 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287006447 PPE family; Region: PPE; pfam00823 1168287006448 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1168287006449 active site 1168287006450 SAM binding site [chemical binding]; other site 1168287006451 homodimer interface [polypeptide binding]; other site 1168287006452 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1168287006453 active site 1168287006454 SAM binding site [chemical binding]; other site 1168287006455 homodimer interface [polypeptide binding]; other site 1168287006456 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1168287006457 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1168287006458 precorrin-3B synthase; Region: CobG; TIGR02435 1168287006459 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1168287006460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287006461 dimer interface [polypeptide binding]; other site 1168287006462 conserved gate region; other site 1168287006463 putative PBP binding loops; other site 1168287006464 ABC-ATPase subunit interface; other site 1168287006465 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1168287006466 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1168287006467 Walker A/P-loop; other site 1168287006468 ATP binding site [chemical binding]; other site 1168287006469 Q-loop/lid; other site 1168287006470 ABC transporter signature motif; other site 1168287006471 Walker B; other site 1168287006472 D-loop; other site 1168287006473 H-loop/switch region; other site 1168287006474 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1168287006475 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287006476 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1168287006477 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1168287006478 Moco binding site; other site 1168287006479 metal coordination site [ion binding]; other site 1168287006480 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1168287006481 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1168287006482 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1168287006483 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287006484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006485 NAD(P) binding site [chemical binding]; other site 1168287006486 active site 1168287006487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006489 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1168287006490 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1168287006491 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1168287006492 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1168287006493 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1168287006494 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1168287006495 active site 1168287006496 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1168287006497 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1168287006498 putative active site [active] 1168287006499 catalytic triad [active] 1168287006500 putative dimer interface [polypeptide binding]; other site 1168287006501 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1168287006502 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1168287006503 Ligand binding site; other site 1168287006504 Putative Catalytic site; other site 1168287006505 DXD motif; other site 1168287006506 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1168287006507 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168287006508 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287006509 active site 1168287006510 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287006511 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1168287006512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006513 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1168287006514 Enoylreductase; Region: PKS_ER; smart00829 1168287006515 NAD(P) binding site [chemical binding]; other site 1168287006516 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1168287006517 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287006518 putative NADP binding site [chemical binding]; other site 1168287006519 active site 1168287006520 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287006521 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168287006522 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287006523 active site 1168287006524 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287006525 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1168287006526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006527 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1168287006528 Enoylreductase; Region: PKS_ER; smart00829 1168287006529 NAD(P) binding site [chemical binding]; other site 1168287006530 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1168287006531 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287006532 putative NADP binding site [chemical binding]; other site 1168287006533 active site 1168287006534 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287006535 hypothetical protein; Provisional; Region: PRK05865 1168287006536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006537 NAD(P) binding site [chemical binding]; other site 1168287006538 active site 1168287006539 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1168287006540 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287006541 Cytochrome P450; Region: p450; cl12078 1168287006542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006543 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1168287006544 NAD(P) binding site [chemical binding]; other site 1168287006545 active site 1168287006546 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287006547 active site 1168287006548 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287006549 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287006550 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1168287006551 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1168287006552 Walker A motif; other site 1168287006553 ATP binding site [chemical binding]; other site 1168287006554 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1168287006555 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1168287006556 metal ion-dependent adhesion site (MIDAS); other site 1168287006557 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287006558 short chain dehydrogenase; Provisional; Region: PRK07814 1168287006559 classical (c) SDRs; Region: SDR_c; cd05233 1168287006560 NAD(P) binding site [chemical binding]; other site 1168287006561 active site 1168287006562 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287006563 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287006564 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287006565 classical (c) SDRs; Region: SDR_c; cd05233 1168287006566 NAD(P) binding site [chemical binding]; other site 1168287006567 active site 1168287006568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006570 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287006571 Cytochrome P450; Region: p450; cl12078 1168287006572 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1168287006573 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287006574 substrate binding pocket [chemical binding]; other site 1168287006575 catalytic triad [active] 1168287006576 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287006577 Ecdysteroid kinase; Region: EcKinase; cl17738 1168287006578 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1168287006579 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1168287006580 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1168287006581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1168287006582 AAA domain; Region: AAA_33; pfam13671 1168287006583 Predicted membrane protein [Function unknown]; Region: COG2259 1168287006584 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1168287006585 catalytic triad [active] 1168287006586 conserved cis-peptide bond; other site 1168287006587 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1168287006588 DoxX-like family; Region: DoxX_2; pfam13564 1168287006589 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1168287006590 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287006591 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1168287006592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1168287006593 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168287006594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287006595 dimer interface [polypeptide binding]; other site 1168287006596 conserved gate region; other site 1168287006597 putative PBP binding loops; other site 1168287006598 ABC-ATPase subunit interface; other site 1168287006599 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168287006600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287006601 dimer interface [polypeptide binding]; other site 1168287006602 conserved gate region; other site 1168287006603 putative PBP binding loops; other site 1168287006604 ABC-ATPase subunit interface; other site 1168287006605 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1168287006606 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1168287006607 Walker A/P-loop; other site 1168287006608 ATP binding site [chemical binding]; other site 1168287006609 Q-loop/lid; other site 1168287006610 ABC transporter signature motif; other site 1168287006611 Walker B; other site 1168287006612 D-loop; other site 1168287006613 H-loop/switch region; other site 1168287006614 TOBE domain; Region: TOBE_2; pfam08402 1168287006615 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1168287006616 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1168287006617 nucleophile elbow; other site 1168287006618 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1168287006619 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1168287006620 Iron permease FTR1 family; Region: FTR1; cl00475 1168287006621 Imelysin; Region: Peptidase_M75; pfam09375 1168287006622 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1168287006623 OsmC-like protein; Region: OsmC; pfam02566 1168287006624 cyanate hydratase; Validated; Region: PRK02866 1168287006625 Helix-turn-helix domain; Region: HTH_19; pfam12844 1168287006626 non-specific DNA binding site [nucleotide binding]; other site 1168287006627 salt bridge; other site 1168287006628 sequence-specific DNA binding site [nucleotide binding]; other site 1168287006629 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1168287006630 oligomer interface [polypeptide binding]; other site 1168287006631 active site 1168287006632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287006633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287006634 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 1168287006635 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1168287006636 DNA binding residues [nucleotide binding] 1168287006637 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1168287006638 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1168287006639 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287006640 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287006641 active site 1168287006642 catalytic tetrad [active] 1168287006643 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1168287006644 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1168287006645 putative NADP binding site [chemical binding]; other site 1168287006646 putative substrate binding site [chemical binding]; other site 1168287006647 active site 1168287006648 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1168287006649 extended (e) SDRs; Region: SDR_e; cd08946 1168287006650 NAD(P) binding site [chemical binding]; other site 1168287006651 active site 1168287006652 substrate binding site [chemical binding]; other site 1168287006653 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287006654 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168287006655 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287006656 active site 2 [active] 1168287006657 active site 1 [active] 1168287006658 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1168287006659 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287006660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287006661 active site 1168287006662 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1168287006663 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287006664 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1168287006665 homotetramer interface [polypeptide binding]; other site 1168287006666 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287006667 NAD binding site [chemical binding]; other site 1168287006668 homodimer interface [polypeptide binding]; other site 1168287006669 active site 1168287006670 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168287006671 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287006672 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287006673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006674 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287006675 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287006676 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287006677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287006678 substrate binding site [chemical binding]; other site 1168287006679 oxyanion hole (OAH) forming residues; other site 1168287006680 trimer interface [polypeptide binding]; other site 1168287006681 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1168287006682 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1168287006683 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1168287006684 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1168287006685 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1168287006686 active site 1168287006687 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1168287006688 catalytic triad [active] 1168287006689 dimer interface [polypeptide binding]; other site 1168287006690 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1168287006691 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1168287006692 active site 1168287006693 Homeodomain-like domain; Region: HTH_23; pfam13384 1168287006694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1168287006695 Integrase core domain; Region: rve; pfam00665 1168287006696 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1168287006697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287006698 Walker A motif; other site 1168287006699 ATP binding site [chemical binding]; other site 1168287006700 Walker B motif; other site 1168287006701 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1168287006702 active site 1168287006703 ATP binding site [chemical binding]; other site 1168287006704 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287006705 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1168287006706 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1168287006707 potential catalytic triad [active] 1168287006708 conserved cys residue [active] 1168287006709 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287006710 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287006711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006712 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1168287006713 NAD(P) binding site [chemical binding]; other site 1168287006714 active site 1168287006715 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1168287006716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287006717 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1168287006718 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1168287006719 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1168287006720 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287006721 hydrophobic ligand binding site; other site 1168287006722 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1168287006723 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1168287006724 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1168287006725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006726 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1168287006727 Cutinase; Region: Cutinase; pfam01083 1168287006728 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1168287006729 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287006730 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1168287006731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287006732 active site 1168287006733 phosphorylation site [posttranslational modification] 1168287006734 intermolecular recognition site; other site 1168287006735 dimerization interface [polypeptide binding]; other site 1168287006736 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1168287006737 Cutinase; Region: Cutinase; pfam01083 1168287006738 PPE family; Region: PPE; pfam00823 1168287006739 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287006740 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1168287006741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1168287006742 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1168287006743 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1168287006744 Walker A/P-loop; other site 1168287006745 ATP binding site [chemical binding]; other site 1168287006746 Q-loop/lid; other site 1168287006747 ABC transporter signature motif; other site 1168287006748 Walker B; other site 1168287006749 D-loop; other site 1168287006750 H-loop/switch region; other site 1168287006751 NMT1-like family; Region: NMT1_2; pfam13379 1168287006752 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1168287006753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168287006754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287006755 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1168287006756 putative dimerization interface [polypeptide binding]; other site 1168287006757 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287006758 PPE family; Region: PPE; pfam00823 1168287006759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1168287006760 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1168287006761 Condensation domain; Region: Condensation; pfam00668 1168287006762 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1168287006763 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287006764 short chain dehydrogenase; Provisional; Region: PRK06500 1168287006765 classical (c) SDRs; Region: SDR_c; cd05233 1168287006766 NAD(P) binding site [chemical binding]; other site 1168287006767 active site 1168287006768 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1168287006769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287006770 S-adenosylmethionine binding site [chemical binding]; other site 1168287006771 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1168287006772 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1168287006773 putative oligomer interface [polypeptide binding]; other site 1168287006774 putative active site [active] 1168287006775 metal binding site [ion binding]; metal-binding site 1168287006776 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1168287006777 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287006778 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287006779 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1168287006780 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1168287006781 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1168287006782 hypothetical protein; Provisional; Region: PRK06834 1168287006783 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287006784 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1168287006785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287006786 ATP binding site [chemical binding]; other site 1168287006787 putative Mg++ binding site [ion binding]; other site 1168287006788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287006789 nucleotide binding region [chemical binding]; other site 1168287006790 ATP-binding site [chemical binding]; other site 1168287006791 Helicase associated domain (HA2); Region: HA2; pfam04408 1168287006792 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1168287006793 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1168287006794 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1168287006795 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1168287006796 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287006797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287006798 substrate binding site [chemical binding]; other site 1168287006799 oxyanion hole (OAH) forming residues; other site 1168287006800 trimer interface [polypeptide binding]; other site 1168287006801 Cutinase; Region: Cutinase; pfam01083 1168287006802 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1168287006803 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287006804 catalytic Zn binding site [ion binding]; other site 1168287006805 NAD(P) binding site [chemical binding]; other site 1168287006806 structural Zn binding site [ion binding]; other site 1168287006807 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287006808 hydrophobic ligand binding site; other site 1168287006809 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1168287006810 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287006811 NAD binding site [chemical binding]; other site 1168287006812 catalytic Zn binding site [ion binding]; other site 1168287006813 structural Zn binding site [ion binding]; other site 1168287006814 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1168287006815 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1168287006816 MOSC domain; Region: MOSC; pfam03473 1168287006817 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287006818 PPE family; Region: PPE; pfam00823 1168287006819 Short C-terminal domain; Region: SHOCT; pfam09851 1168287006820 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1168287006821 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1168287006822 active site 1168287006823 TDP-binding site; other site 1168287006824 acceptor substrate-binding pocket; other site 1168287006825 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1168287006826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287006827 S-adenosylmethionine binding site [chemical binding]; other site 1168287006828 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1168287006829 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287006830 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1168287006831 iron-sulfur cluster [ion binding]; other site 1168287006832 [2Fe-2S] cluster binding site [ion binding]; other site 1168287006833 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1168287006834 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1168287006835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1168287006836 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168287006837 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1168287006838 metal binding site 2 [ion binding]; metal-binding site 1168287006839 putative DNA binding helix; other site 1168287006840 metal binding site 1 [ion binding]; metal-binding site 1168287006841 dimer interface [polypeptide binding]; other site 1168287006842 structural Zn2+ binding site [ion binding]; other site 1168287006843 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1168287006844 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1168287006845 dimer interface [polypeptide binding]; other site 1168287006846 active site 1168287006847 heme binding site [chemical binding]; other site 1168287006848 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1168287006849 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1168287006850 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287006851 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287006852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287006853 S-adenosylmethionine binding site [chemical binding]; other site 1168287006854 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1168287006855 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1168287006856 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1168287006857 Cutinase; Region: Cutinase; pfam01083 1168287006858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287006859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006860 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287006861 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287006862 PE family; Region: PE; pfam00934 1168287006863 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1168287006864 active site 1168287006865 catalytic residues [active] 1168287006866 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287006867 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1168287006868 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1168287006869 Phage capsid family; Region: Phage_capsid; pfam05065 1168287006870 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1168287006871 Phage Terminase; Region: Terminase_1; pfam03354 1168287006872 Helix-turn-helix domain; Region: HTH_17; pfam12728 1168287006873 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1168287006874 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1168287006875 catalytic residues [active] 1168287006876 Recombinase; Region: Recombinase; pfam07508 1168287006877 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1168287006878 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287006879 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287006880 NAD(P) binding site [chemical binding]; other site 1168287006881 catalytic residues [active] 1168287006882 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1168287006883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287006884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287006885 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1168287006886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287006887 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287006888 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1168287006889 putative acyl-acceptor binding pocket; other site 1168287006890 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1168287006891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287006892 S-adenosylmethionine binding site [chemical binding]; other site 1168287006893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006894 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287006895 extended (e) SDRs; Region: SDR_e; cd08946 1168287006896 NAD(P) binding site [chemical binding]; other site 1168287006897 active site 1168287006898 substrate binding site [chemical binding]; other site 1168287006899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287006900 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287006901 active site 1168287006902 YacP-like NYN domain; Region: NYN_YacP; cl01491 1168287006903 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1168287006904 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287006905 FMN binding site [chemical binding]; other site 1168287006906 substrate binding site [chemical binding]; other site 1168287006907 putative catalytic residue [active] 1168287006908 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1168287006909 dimer interface [polypeptide binding]; other site 1168287006910 catalytic triad [active] 1168287006911 peroxidatic and resolving cysteines [active] 1168287006912 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1168287006913 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1168287006914 conserved cys residue [active] 1168287006915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287006916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287006917 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1168287006918 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1168287006919 conserved cys residue [active] 1168287006920 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287006921 short chain dehydrogenase; Provisional; Region: PRK05867 1168287006922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287006923 NAD(P) binding site [chemical binding]; other site 1168287006924 active site 1168287006925 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287006926 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287006927 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1168287006928 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1168287006929 acyl-activating enzyme (AAE) consensus motif; other site 1168287006930 active site 1168287006931 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1168287006932 putative hydrophobic ligand binding site [chemical binding]; other site 1168287006933 protein interface [polypeptide binding]; other site 1168287006934 gate; other site 1168287006935 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1168287006936 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1168287006937 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1168287006938 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1168287006939 tetramer interface [polypeptide binding]; other site 1168287006940 active site 1168287006941 Mg2+/Mn2+ binding site [ion binding]; other site 1168287006942 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1168287006943 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287006944 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287006945 dimerization interface [polypeptide binding]; other site 1168287006946 putative DNA binding site [nucleotide binding]; other site 1168287006947 putative Zn2+ binding site [ion binding]; other site 1168287006948 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1168287006949 putative hydrophobic ligand binding site [chemical binding]; other site 1168287006950 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1168287006951 putative hydrophobic ligand binding site [chemical binding]; other site 1168287006952 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1168287006953 substrate binding site [chemical binding]; other site 1168287006954 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287006955 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287006956 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287006957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287006958 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1168287006959 Nitronate monooxygenase; Region: NMO; pfam03060 1168287006960 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287006961 FMN binding site [chemical binding]; other site 1168287006962 substrate binding site [chemical binding]; other site 1168287006963 putative catalytic residue [active] 1168287006964 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1168287006965 FMN binding site [chemical binding]; other site 1168287006966 dimer interface [polypeptide binding]; other site 1168287006967 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287006968 hydrophobic ligand binding site; other site 1168287006969 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1168287006970 Predicted membrane protein [Function unknown]; Region: COG1950 1168287006971 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287006972 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287006973 active site 1168287006974 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287006975 putative sialic acid transporter; Region: 2A0112; TIGR00891 1168287006976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287006977 putative substrate translocation pore; other site 1168287006978 competence damage-inducible protein A; Provisional; Region: PRK00549 1168287006979 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1168287006980 putative MPT binding site; other site 1168287006981 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1168287006982 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1168287006983 putative ADP-ribose binding site [chemical binding]; other site 1168287006984 Domain of unknown function DUF77; Region: DUF77; pfam01910 1168287006985 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1168287006986 putative active site [active] 1168287006987 dimerization interface [polypeptide binding]; other site 1168287006988 putative tRNAtyr binding site [nucleotide binding]; other site 1168287006989 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287006990 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287006991 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168287006992 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287006993 NAD(P) binding site [chemical binding]; other site 1168287006994 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287006995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287006996 Nitronate monooxygenase; Region: NMO; pfam03060 1168287006997 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287006998 FMN binding site [chemical binding]; other site 1168287006999 substrate binding site [chemical binding]; other site 1168287007000 putative catalytic residue [active] 1168287007001 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287007002 Cytochrome P450; Region: p450; cl12078 1168287007003 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1168287007004 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1168287007005 putative NAD(P) binding site [chemical binding]; other site 1168287007006 putative substrate binding site [chemical binding]; other site 1168287007007 catalytic Zn binding site [ion binding]; other site 1168287007008 structural Zn binding site [ion binding]; other site 1168287007009 YceI-like domain; Region: YceI; smart00867 1168287007010 Putative esterase; Region: Esterase; pfam00756 1168287007011 chorismate mutase; Provisional; Region: PRK09269 1168287007012 Chorismate mutase type II; Region: CM_2; cl00693 1168287007013 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1168287007014 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287007015 hydrophobic ligand binding site; other site 1168287007016 short chain dehydrogenase; Provisional; Region: PRK08267 1168287007017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287007018 NAD(P) binding site [chemical binding]; other site 1168287007019 active site 1168287007020 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1168287007021 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287007022 Cytochrome P450; Region: p450; cl12078 1168287007023 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287007024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287007025 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1168287007026 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168287007027 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1168287007028 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287007029 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287007030 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287007031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287007032 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168287007033 putative substrate translocation pore; other site 1168287007034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287007035 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1168287007036 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1168287007037 heme binding site [chemical binding]; other site 1168287007038 ferroxidase pore; other site 1168287007039 ferroxidase diiron center [ion binding]; other site 1168287007040 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1168287007041 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287007042 substrate binding site [chemical binding]; other site 1168287007043 oxyanion hole (OAH) forming residues; other site 1168287007044 trimer interface [polypeptide binding]; other site 1168287007045 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1168287007046 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1168287007047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287007048 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1168287007049 dimerization interface [polypeptide binding]; other site 1168287007050 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1168287007051 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1168287007052 dimer interface [polypeptide binding]; other site 1168287007053 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1168287007054 catalytic triad [active] 1168287007055 peroxidatic and resolving cysteines [active] 1168287007056 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1168287007057 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287007058 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1168287007059 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168287007060 active site 1168287007061 catalytic site [active] 1168287007062 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1168287007063 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1168287007064 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1168287007065 active site 1168287007066 substrate binding site [chemical binding]; other site 1168287007067 FMN binding site [chemical binding]; other site 1168287007068 putative catalytic residues [active] 1168287007069 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1168287007070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287007071 Walker A motif; other site 1168287007072 ATP binding site [chemical binding]; other site 1168287007073 Walker B motif; other site 1168287007074 arginine finger; other site 1168287007075 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1168287007076 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287007077 TfoX N-terminal domain; Region: TfoX_N; cl17592 1168287007078 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1168287007079 minor groove reading motif; other site 1168287007080 helix-hairpin-helix signature motif; other site 1168287007081 Protein of unknown function DUF72; Region: DUF72; pfam01904 1168287007082 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1168287007083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287007084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287007085 hypothetical protein; Provisional; Region: PRK12320 1168287007086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287007087 NAD(P) binding site [chemical binding]; other site 1168287007088 active site 1168287007089 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1168287007090 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287007091 active site 1168287007092 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287007093 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287007094 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287007095 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287007096 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1168287007097 short chain dehydrogenase; Provisional; Region: PRK07825 1168287007098 classical (c) SDRs; Region: SDR_c; cd05233 1168287007099 NAD(P) binding site [chemical binding]; other site 1168287007100 active site 1168287007101 putative phosphoketolase; Provisional; Region: PRK05261 1168287007102 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1168287007103 TPP-binding site; other site 1168287007104 XFP C-terminal domain; Region: XFP_C; pfam09363 1168287007105 CAAX protease self-immunity; Region: Abi; pfam02517 1168287007106 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168287007107 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1168287007108 NAD(P) binding site [chemical binding]; other site 1168287007109 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1168287007110 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1168287007111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287007112 Walker A/P-loop; other site 1168287007113 ATP binding site [chemical binding]; other site 1168287007114 Q-loop/lid; other site 1168287007115 ABC transporter signature motif; other site 1168287007116 Walker B; other site 1168287007117 D-loop; other site 1168287007118 H-loop/switch region; other site 1168287007119 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1168287007120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287007121 putative PBP binding loops; other site 1168287007122 ABC-ATPase subunit interface; other site 1168287007123 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1168287007124 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1168287007125 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1168287007126 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1168287007127 classical (c) SDRs; Region: SDR_c; cd05233 1168287007128 NAD(P) binding site [chemical binding]; other site 1168287007129 active site 1168287007130 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1168287007131 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287007132 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287007133 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1168287007134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287007135 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287007136 CoenzymeA binding site [chemical binding]; other site 1168287007137 subunit interaction site [polypeptide binding]; other site 1168287007138 PHB binding site; other site 1168287007139 Predicted transcriptional regulator [Transcription]; Region: COG3682 1168287007140 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1168287007141 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168287007142 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1168287007143 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1168287007144 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1168287007145 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168287007146 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1168287007147 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1168287007148 active site 1168287007149 acyl carrier protein; Validated; Region: PRK05883 1168287007150 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1168287007151 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007152 acyl-activating enzyme (AAE) consensus motif; other site 1168287007153 AMP binding site [chemical binding]; other site 1168287007154 active site 1168287007155 CoA binding site [chemical binding]; other site 1168287007156 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1168287007157 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287007158 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287007159 active site 1168287007160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1168287007161 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1168287007162 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1168287007163 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168287007164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168287007165 Transporter associated domain; Region: CorC_HlyC; smart01091 1168287007166 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1168287007167 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168287007168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168287007169 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1168287007170 active site 1168287007171 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1168287007172 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1168287007173 metal ion-dependent adhesion site (MIDAS); other site 1168287007174 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1168287007175 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1168287007176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287007177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287007178 glycine dehydrogenase; Provisional; Region: PRK05367 1168287007179 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1168287007180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287007181 tetramer interface [polypeptide binding]; other site 1168287007182 catalytic residue [active] 1168287007183 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1168287007184 tetramer interface [polypeptide binding]; other site 1168287007185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287007186 catalytic residue [active] 1168287007187 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1168287007188 DNA binding residues [nucleotide binding] 1168287007189 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168287007190 putative dimer interface [polypeptide binding]; other site 1168287007191 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1168287007192 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1168287007193 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168287007194 DNA binding residues [nucleotide binding] 1168287007195 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287007196 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287007197 phosphopeptide binding site; other site 1168287007198 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1168287007199 lipoyl attachment site [posttranslational modification]; other site 1168287007200 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1168287007201 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1168287007202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1168287007203 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1168287007204 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168287007205 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1168287007206 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1168287007207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1168287007208 nucleotide binding region [chemical binding]; other site 1168287007209 ATP-binding site [chemical binding]; other site 1168287007210 hypothetical protein; Provisional; Region: PRK05858 1168287007211 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168287007212 PYR/PP interface [polypeptide binding]; other site 1168287007213 dimer interface [polypeptide binding]; other site 1168287007214 TPP binding site [chemical binding]; other site 1168287007215 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287007216 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1168287007217 TPP-binding site; other site 1168287007218 dimer interface [polypeptide binding]; other site 1168287007219 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1168287007220 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1168287007221 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1168287007222 hypothetical protein; Validated; Region: PRK07121 1168287007223 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168287007224 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287007225 active site 1168287007226 metal binding site [ion binding]; metal-binding site 1168287007227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287007228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287007229 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1168287007230 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1168287007231 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1168287007232 MgtC family; Region: MgtC; pfam02308 1168287007233 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287007234 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007235 PPE family; Region: PPE; pfam00823 1168287007236 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287007237 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007238 PPE family; Region: PPE; pfam00823 1168287007239 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287007240 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287007241 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287007242 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007243 PPE family; Region: PPE; pfam00823 1168287007244 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287007245 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007246 PPE family; Region: PPE; pfam00823 1168287007247 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287007248 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007249 PPE family; Region: PPE; pfam00823 1168287007250 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1168287007251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287007252 Walker A motif; other site 1168287007253 ATP binding site [chemical binding]; other site 1168287007254 Walker B motif; other site 1168287007255 arginine finger; other site 1168287007256 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1168287007257 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1168287007258 catalytic residues [active] 1168287007259 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1168287007260 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1168287007261 active site 1168287007262 catalytic residues [active] 1168287007263 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1168287007264 EspG family; Region: ESX-1_EspG; pfam14011 1168287007265 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1168287007266 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1168287007267 PE family; Region: PE; pfam00934 1168287007268 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007269 PPE family; Region: PPE; pfam00823 1168287007270 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007271 PPE family; Region: PPE; pfam00823 1168287007272 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287007273 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1168287007274 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287007275 Cytochrome P450; Region: p450; cl12078 1168287007276 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1168287007277 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287007278 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1168287007279 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287007280 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1168287007281 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1168287007282 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1168287007283 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287007284 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287007285 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287007286 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1168287007287 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1168287007288 Moco binding site; other site 1168287007289 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1168287007290 metal coordination site [ion binding]; other site 1168287007291 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1168287007292 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1168287007293 hydrophobic ligand binding site; other site 1168287007294 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1168287007295 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287007296 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287007297 Helix-turn-helix domain; Region: HTH_18; pfam12833 1168287007298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287007299 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287007300 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287007301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287007302 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287007303 classical (c) SDRs; Region: SDR_c; cd05233 1168287007304 NAD(P) binding site [chemical binding]; other site 1168287007305 active site 1168287007306 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1168287007307 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1168287007308 tetramer interface [polypeptide binding]; other site 1168287007309 TPP-binding site [chemical binding]; other site 1168287007310 heterodimer interface [polypeptide binding]; other site 1168287007311 phosphorylation loop region [posttranslational modification] 1168287007312 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1168287007313 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1168287007314 alpha subunit interface [polypeptide binding]; other site 1168287007315 TPP binding site [chemical binding]; other site 1168287007316 heterodimer interface [polypeptide binding]; other site 1168287007317 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168287007318 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1168287007319 E3 interaction surface; other site 1168287007320 lipoyl attachment site [posttranslational modification]; other site 1168287007321 enoyl-CoA hydratase; Provisional; Region: PRK06144 1168287007322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287007323 substrate binding site [chemical binding]; other site 1168287007324 oxyanion hole (OAH) forming residues; other site 1168287007325 trimer interface [polypeptide binding]; other site 1168287007326 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1168287007327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007328 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287007329 acyl-activating enzyme (AAE) consensus motif; other site 1168287007330 putative AMP binding site [chemical binding]; other site 1168287007331 putative active site [active] 1168287007332 acyl-activating enzyme (AAE) consensus motif; other site 1168287007333 putative CoA binding site [chemical binding]; other site 1168287007334 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287007335 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287007336 [2Fe-2S] cluster binding site [ion binding]; other site 1168287007337 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287007338 hydrophobic ligand binding site; other site 1168287007339 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1168287007340 enoyl-CoA hydratase; Provisional; Region: PRK06190 1168287007341 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287007342 substrate binding site [chemical binding]; other site 1168287007343 oxyanion hole (OAH) forming residues; other site 1168287007344 trimer interface [polypeptide binding]; other site 1168287007345 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1168287007346 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1168287007347 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 1168287007348 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1168287007349 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1168287007350 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168287007351 ATP binding site [chemical binding]; other site 1168287007352 Mg++ binding site [ion binding]; other site 1168287007353 motif III; other site 1168287007354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287007355 nucleotide binding region [chemical binding]; other site 1168287007356 ATP-binding site [chemical binding]; other site 1168287007357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287007358 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287007359 S-adenosylmethionine binding site [chemical binding]; other site 1168287007360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287007361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287007362 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1168287007363 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287007364 active site 1168287007365 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287007366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287007367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287007368 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287007369 classical (c) SDRs; Region: SDR_c; cd05233 1168287007370 NAD(P) binding site [chemical binding]; other site 1168287007371 active site 1168287007372 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1168287007373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287007374 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1168287007375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287007376 DNA binding residues [nucleotide binding] 1168287007377 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1168287007378 Domain of unknown function (DUF385); Region: DUF385; cl04387 1168287007379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287007380 Cytochrome P450; Region: p450; cl12078 1168287007381 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287007382 short chain dehydrogenase; Provisional; Region: PRK05854 1168287007383 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1168287007384 putative NAD(P) binding site [chemical binding]; other site 1168287007385 active site 1168287007386 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287007387 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168287007388 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1168287007389 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1168287007390 active site 1168287007391 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168287007392 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1168287007393 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1168287007394 active site 1168287007395 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287007396 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287007397 active site 1168287007398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287007399 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1168287007400 NAD(P) binding site [chemical binding]; other site 1168287007401 active site 1168287007402 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287007403 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287007404 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287007405 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287007406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287007407 enoyl-CoA hydratase; Provisional; Region: PRK12478 1168287007408 substrate binding site [chemical binding]; other site 1168287007409 oxyanion hole (OAH) forming residues; other site 1168287007410 trimer interface [polypeptide binding]; other site 1168287007411 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287007412 classical (c) SDRs; Region: SDR_c; cd05233 1168287007413 NAD(P) binding site [chemical binding]; other site 1168287007414 active site 1168287007415 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287007416 Cytochrome P450; Region: p450; cl12078 1168287007417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1168287007418 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1168287007419 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1168287007420 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1168287007421 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1168287007422 hypothetical protein; Provisional; Region: PRK06185 1168287007423 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287007424 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287007425 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1168287007426 Sulfatase; Region: Sulfatase; pfam00884 1168287007427 Nitronate monooxygenase; Region: NMO; pfam03060 1168287007428 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287007429 FMN binding site [chemical binding]; other site 1168287007430 substrate binding site [chemical binding]; other site 1168287007431 putative catalytic residue [active] 1168287007432 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287007433 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1168287007434 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287007435 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1168287007436 intersubunit interface [polypeptide binding]; other site 1168287007437 active site 1168287007438 Zn2+ binding site [ion binding]; other site 1168287007439 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287007440 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007441 acyl-activating enzyme (AAE) consensus motif; other site 1168287007442 AMP binding site [chemical binding]; other site 1168287007443 active site 1168287007444 CoA binding site [chemical binding]; other site 1168287007445 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1168287007446 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1168287007447 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1168287007448 Moco binding site; other site 1168287007449 metal coordination site [ion binding]; other site 1168287007450 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1168287007451 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1168287007452 putative di-iron ligands [ion binding]; other site 1168287007453 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1168287007454 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1168287007455 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1168287007456 FAD binding pocket [chemical binding]; other site 1168287007457 FAD binding motif [chemical binding]; other site 1168287007458 phosphate binding motif [ion binding]; other site 1168287007459 beta-alpha-beta structure motif; other site 1168287007460 NAD binding pocket [chemical binding]; other site 1168287007461 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287007462 catalytic loop [active] 1168287007463 iron binding site [ion binding]; other site 1168287007464 acyl-CoA synthetase; Provisional; Region: PRK13388 1168287007465 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007466 acyl-activating enzyme (AAE) consensus motif; other site 1168287007467 AMP binding site [chemical binding]; other site 1168287007468 active site 1168287007469 CoA binding site [chemical binding]; other site 1168287007470 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287007471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287007472 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287007473 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287007474 thiolase; Provisional; Region: PRK06158 1168287007475 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287007476 active site 1168287007477 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1168287007478 putative active site [active] 1168287007479 putative catalytic site [active] 1168287007480 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1168287007481 active site 1168287007482 catalytic site [active] 1168287007483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287007484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287007485 active site 1168287007486 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287007487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287007488 active site 1168287007489 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287007490 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287007491 phosphopeptide binding site; other site 1168287007492 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287007493 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287007494 phosphopeptide binding site; other site 1168287007495 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1168287007496 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168287007497 Walker A/P-loop; other site 1168287007498 ATP binding site [chemical binding]; other site 1168287007499 Q-loop/lid; other site 1168287007500 ABC transporter signature motif; other site 1168287007501 Walker B; other site 1168287007502 D-loop; other site 1168287007503 H-loop/switch region; other site 1168287007504 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1168287007505 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1168287007506 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287007507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287007508 short chain dehydrogenase; Provisional; Region: PRK06057 1168287007509 classical (c) SDRs; Region: SDR_c; cd05233 1168287007510 NAD(P) binding site [chemical binding]; other site 1168287007511 active site 1168287007512 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287007513 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1168287007514 molybdopterin cofactor binding site; other site 1168287007515 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1168287007516 putative molybdopterin cofactor binding site; other site 1168287007517 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287007518 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287007519 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287007520 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287007521 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1168287007522 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287007523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287007524 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168287007525 NAD(P) binding site [chemical binding]; other site 1168287007526 active site 1168287007527 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287007528 classical (c) SDRs; Region: SDR_c; cd05233 1168287007529 NAD(P) binding site [chemical binding]; other site 1168287007530 active site 1168287007531 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287007532 classical (c) SDRs; Region: SDR_c; cd05233 1168287007533 NAD(P) binding site [chemical binding]; other site 1168287007534 active site 1168287007535 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287007536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287007537 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1168287007538 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287007539 catalytic loop [active] 1168287007540 iron binding site [ion binding]; other site 1168287007541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287007542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287007543 active site 1168287007544 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1168287007545 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1168287007546 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1168287007547 active site 1168287007548 Fe binding site [ion binding]; other site 1168287007549 hypothetical protein; Validated; Region: PRK07121 1168287007550 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168287007551 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168287007552 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1168287007553 Bacterial transcriptional regulator; Region: IclR; pfam01614 1168287007554 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287007555 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287007556 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287007557 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1168287007558 active site 1168287007559 FMN binding site [chemical binding]; other site 1168287007560 substrate binding site [chemical binding]; other site 1168287007561 putative catalytic residue [active] 1168287007562 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1168287007563 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 1168287007564 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168287007565 NAD(P) binding site [chemical binding]; other site 1168287007566 homodimer interface [polypeptide binding]; other site 1168287007567 active site 1168287007568 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287007569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287007570 acyl-CoA synthetase; Validated; Region: PRK08316 1168287007571 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007572 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287007573 acyl-activating enzyme (AAE) consensus motif; other site 1168287007574 putative AMP binding site [chemical binding]; other site 1168287007575 putative active site [active] 1168287007576 putative CoA binding site [chemical binding]; other site 1168287007577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287007578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287007579 active site 1168287007580 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287007581 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287007582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287007583 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287007584 hypothetical protein; Provisional; Region: PRK06194 1168287007585 classical (c) SDRs; Region: SDR_c; cd05233 1168287007586 NAD(P) binding site [chemical binding]; other site 1168287007587 active site 1168287007588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287007589 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287007590 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287007591 classical (c) SDRs; Region: SDR_c; cd05233 1168287007592 NAD(P) binding site [chemical binding]; other site 1168287007593 active site 1168287007594 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287007595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287007596 NAD(P) binding site [chemical binding]; other site 1168287007597 active site 1168287007598 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287007599 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1168287007600 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1168287007601 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168287007602 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287007603 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287007604 active site 1168287007605 Predicted transcriptional regulators [Transcription]; Region: COG1695 1168287007606 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1168287007607 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287007608 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287007609 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1168287007610 amino acid transporter; Region: 2A0306; TIGR00909 1168287007611 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1168287007612 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1168287007613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1168287007614 Probable transposase; Region: OrfB_IS605; pfam01385 1168287007615 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1168287007616 hypothetical protein; Provisional; Region: PRK14059 1168287007617 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1168287007618 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287007619 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287007620 active site 1168287007621 ATP binding site [chemical binding]; other site 1168287007622 substrate binding site [chemical binding]; other site 1168287007623 activation loop (A-loop); other site 1168287007624 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1168287007625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287007626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287007627 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1168287007628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168287007629 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287007630 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287007631 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1168287007632 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1168287007633 active site 1168287007634 dimer interface [polypeptide binding]; other site 1168287007635 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1168287007636 Ligand Binding Site [chemical binding]; other site 1168287007637 Molecular Tunnel; other site 1168287007638 Condensation domain; Region: Condensation; pfam00668 1168287007639 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007640 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287007641 acyl-activating enzyme (AAE) consensus motif; other site 1168287007642 AMP binding site [chemical binding]; other site 1168287007643 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007644 Condensation domain; Region: Condensation; pfam00668 1168287007645 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287007646 Condensation domain; Region: Condensation; pfam00668 1168287007647 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007648 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007649 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287007650 acyl-activating enzyme (AAE) consensus motif; other site 1168287007651 AMP binding site [chemical binding]; other site 1168287007652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287007653 S-adenosylmethionine binding site [chemical binding]; other site 1168287007654 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007655 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007656 Condensation domain; Region: Condensation; pfam00668 1168287007657 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287007658 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007659 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007660 acyl-activating enzyme (AAE) consensus motif; other site 1168287007661 AMP binding site [chemical binding]; other site 1168287007662 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007663 Condensation domain; Region: Condensation; pfam00668 1168287007664 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287007665 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007666 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007667 acyl-activating enzyme (AAE) consensus motif; other site 1168287007668 AMP binding site [chemical binding]; other site 1168287007669 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007670 peptide synthase; Provisional; Region: PRK12316 1168287007671 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007672 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007673 acyl-activating enzyme (AAE) consensus motif; other site 1168287007674 AMP binding site [chemical binding]; other site 1168287007675 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007676 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287007677 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007678 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007679 acyl-activating enzyme (AAE) consensus motif; other site 1168287007680 AMP binding site [chemical binding]; other site 1168287007681 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007682 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007683 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007684 acyl-activating enzyme (AAE) consensus motif; other site 1168287007685 AMP binding site [chemical binding]; other site 1168287007686 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007687 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287007688 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007689 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007690 acyl-activating enzyme (AAE) consensus motif; other site 1168287007691 AMP binding site [chemical binding]; other site 1168287007692 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007693 Thioesterase domain; Region: Thioesterase; pfam00975 1168287007694 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1168287007695 nudix motif; other site 1168287007696 MbtH-like protein; Region: MbtH; pfam03621 1168287007697 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1168287007698 ANTAR domain; Region: ANTAR; pfam03861 1168287007699 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1168287007700 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1168287007701 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168287007702 DNA-binding site [nucleotide binding]; DNA binding site 1168287007703 RNA-binding motif; other site 1168287007704 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1168287007705 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1168287007706 putative di-iron ligands [ion binding]; other site 1168287007707 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1168287007708 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1168287007709 NAD(P) binding site [chemical binding]; other site 1168287007710 catalytic residues [active] 1168287007711 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1168287007712 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1168287007713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1168287007714 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287007715 Peptidase family M48; Region: Peptidase_M48; cl12018 1168287007716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1168287007717 Transposase; Region: HTH_Tnp_1; pfam01527 1168287007718 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1168287007719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287007720 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1168287007721 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1168287007722 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1168287007723 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1168287007724 DNA binding residues [nucleotide binding] 1168287007725 dimer interface [polypeptide binding]; other site 1168287007726 metal binding site [ion binding]; metal-binding site 1168287007727 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1168287007728 Putative zinc-finger; Region: zf-HC2; pfam13490 1168287007729 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1168287007730 Homeodomain-like domain; Region: HTH_23; pfam13384 1168287007731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1168287007732 Integrase core domain; Region: rve; pfam00665 1168287007733 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1168287007734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287007735 Walker A motif; other site 1168287007736 ATP binding site [chemical binding]; other site 1168287007737 Walker B motif; other site 1168287007738 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1168287007739 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1168287007740 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1168287007741 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1168287007742 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1168287007743 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1168287007744 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287007745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287007746 active site 1168287007747 motif I; other site 1168287007748 motif II; other site 1168287007749 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1168287007750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287007751 dimerization interface [polypeptide binding]; other site 1168287007752 putative DNA binding site [nucleotide binding]; other site 1168287007753 putative Zn2+ binding site [ion binding]; other site 1168287007754 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1168287007755 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168287007756 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287007757 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1168287007758 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1168287007759 MgtE intracellular N domain; Region: MgtE_N; smart00924 1168287007760 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1168287007761 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1168287007762 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1168287007763 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1168287007764 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1168287007765 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1168287007766 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1168287007767 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1168287007768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287007769 S-adenosylmethionine binding site [chemical binding]; other site 1168287007770 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168287007771 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168287007772 dimer interface [polypeptide binding]; other site 1168287007773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287007774 catalytic residue [active] 1168287007775 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1168287007776 PE family; Region: PE; pfam00934 1168287007777 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007778 PPE family; Region: PPE; pfam00823 1168287007779 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1168287007780 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1168287007781 NADH dehydrogenase; Region: NADHdh; cl00469 1168287007782 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1168287007783 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168287007784 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00150 1168287007785 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168287007786 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1168287007787 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168287007788 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1168287007789 putative FMN binding site [chemical binding]; other site 1168287007790 NADPH bind site [chemical binding]; other site 1168287007791 Condensation domain; Region: Condensation; pfam00668 1168287007792 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287007793 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007794 acyl-activating enzyme (AAE) consensus motif; other site 1168287007795 AMP binding site [chemical binding]; other site 1168287007796 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007797 Condensation domain; Region: Condensation; pfam00668 1168287007798 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287007799 Condensation domain; Region: Condensation; pfam00668 1168287007800 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007801 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287007802 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287007803 acyl-activating enzyme (AAE) consensus motif; other site 1168287007804 AMP binding site [chemical binding]; other site 1168287007805 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007806 Condensation domain; Region: Condensation; pfam00668 1168287007807 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287007808 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287007809 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007810 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1168287007811 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1168287007812 Thioesterase domain; Region: Thioesterase; pfam00975 1168287007813 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287007814 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1168287007815 active site 1168287007816 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168287007817 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287007818 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1168287007819 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287007820 NADP binding site [chemical binding]; other site 1168287007821 active site 1168287007822 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287007823 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1168287007824 metal-binding site [ion binding] 1168287007825 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168287007826 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1168287007827 metal-binding site [ion binding] 1168287007828 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287007829 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1168287007830 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287007831 PPE family; Region: PPE; pfam00823 1168287007832 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1168287007833 putative homodimer interface [polypeptide binding]; other site 1168287007834 putative homotetramer interface [polypeptide binding]; other site 1168287007835 putative allosteric switch controlling residues; other site 1168287007836 putative metal binding site [ion binding]; other site 1168287007837 putative homodimer-homodimer interface [polypeptide binding]; other site 1168287007838 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168287007839 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168287007840 dimer interface [polypeptide binding]; other site 1168287007841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287007842 catalytic residue [active] 1168287007843 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1168287007844 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1168287007845 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1168287007846 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1168287007847 dimer interface [polypeptide binding]; other site 1168287007848 active site 1168287007849 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168287007850 catalytic residues [active] 1168287007851 substrate binding site [chemical binding]; other site 1168287007852 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1168287007853 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1168287007854 cation binding site [ion binding]; other site 1168287007855 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1168287007856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1168287007857 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287007858 Integrase core domain; Region: rve; pfam00665 1168287007859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287007860 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1168287007861 Walker A motif; other site 1168287007862 ATP binding site [chemical binding]; other site 1168287007863 Walker B motif; other site 1168287007864 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1168287007865 Helix-turn-helix domain; Region: HTH_17; pfam12728 1168287007866 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1168287007867 active site 1168287007868 catalytic residues [active] 1168287007869 DNA binding site [nucleotide binding] 1168287007870 Int/Topo IB signature motif; other site 1168287007871 GTP-binding protein Der; Reviewed; Region: PRK03003 1168287007872 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1168287007873 GTP/Mg2+ binding site [chemical binding]; other site 1168287007874 Switch I region; other site 1168287007875 G2 box; other site 1168287007876 Switch II region; other site 1168287007877 G3 box; other site 1168287007878 G4 box; other site 1168287007879 G5 box; other site 1168287007880 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1168287007881 G1 box; other site 1168287007882 GTP/Mg2+ binding site [chemical binding]; other site 1168287007883 Switch I region; other site 1168287007884 G2 box; other site 1168287007885 G3 box; other site 1168287007886 Switch II region; other site 1168287007887 G4 box; other site 1168287007888 G5 box; other site 1168287007889 cytidylate kinase; Provisional; Region: cmk; PRK00023 1168287007890 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1168287007891 CMP-binding site; other site 1168287007892 The sites determining sugar specificity; other site 1168287007893 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1168287007894 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168287007895 RNA binding surface [nucleotide binding]; other site 1168287007896 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1168287007897 active site 1168287007898 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1168287007899 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1168287007900 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1168287007901 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1168287007902 P loop; other site 1168287007903 Nucleotide binding site [chemical binding]; other site 1168287007904 DTAP/Switch II; other site 1168287007905 Switch I; other site 1168287007906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168287007907 Magnesium ion binding site [ion binding]; other site 1168287007908 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1168287007909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287007910 S-adenosylmethionine binding site [chemical binding]; other site 1168287007911 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1168287007912 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168287007913 active site 1168287007914 DNA binding site [nucleotide binding] 1168287007915 Int/Topo IB signature motif; other site 1168287007916 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1168287007917 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1168287007918 dimer interface [polypeptide binding]; other site 1168287007919 active site 1168287007920 ADP-ribose binding site [chemical binding]; other site 1168287007921 nudix motif; other site 1168287007922 metal binding site [ion binding]; metal-binding site 1168287007923 CTP synthetase; Validated; Region: pyrG; PRK05380 1168287007924 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1168287007925 Catalytic site [active] 1168287007926 active site 1168287007927 UTP binding site [chemical binding]; other site 1168287007928 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1168287007929 active site 1168287007930 putative oxyanion hole; other site 1168287007931 catalytic triad [active] 1168287007932 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1168287007933 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1168287007934 Thiamine pyrophosphokinase; Region: TPK; cl08415 1168287007935 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1168287007936 DNA repair protein RecN; Region: recN; TIGR00634 1168287007937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287007938 Walker A/P-loop; other site 1168287007939 ATP binding site [chemical binding]; other site 1168287007940 Q-loop/lid; other site 1168287007941 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1168287007942 ABC transporter signature motif; other site 1168287007943 Walker B; other site 1168287007944 D-loop; other site 1168287007945 H-loop/switch region; other site 1168287007946 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1168287007947 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1168287007948 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1168287007949 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168287007950 RNA binding surface [nucleotide binding]; other site 1168287007951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287007952 S-adenosylmethionine binding site [chemical binding]; other site 1168287007953 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1168287007954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287007955 active site 1168287007956 motif I; other site 1168287007957 motif II; other site 1168287007958 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1168287007959 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1168287007960 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287007961 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1168287007962 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1168287007963 active site 1168287007964 HIGH motif; other site 1168287007965 dimer interface [polypeptide binding]; other site 1168287007966 KMSKS motif; other site 1168287007967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168287007968 RNA binding surface [nucleotide binding]; other site 1168287007969 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1168287007970 active site 1168287007971 DNA binding site [nucleotide binding] 1168287007972 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1168287007973 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1168287007974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168287007975 Walker A/P-loop; other site 1168287007976 ATP binding site [chemical binding]; other site 1168287007977 Q-loop/lid; other site 1168287007978 ABC transporter signature motif; other site 1168287007979 Walker B; other site 1168287007980 D-loop; other site 1168287007981 H-loop/switch region; other site 1168287007982 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168287007983 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1168287007984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287007985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287007986 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1168287007987 acyl-CoA synthetase; Validated; Region: PRK07868 1168287007988 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1168287007989 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007990 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287007991 active site 1168287007992 CoA binding site [chemical binding]; other site 1168287007993 AMP binding site [chemical binding]; other site 1168287007994 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1168287007995 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1168287007996 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1168287007997 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1168287007998 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1168287007999 short chain dehydrogenase; Provisional; Region: PRK07109 1168287008000 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1168287008001 putative NAD(P) binding site [chemical binding]; other site 1168287008002 active site 1168287008003 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 1168287008004 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1168287008005 putative active site pocket [active] 1168287008006 putative metal binding site [ion binding]; other site 1168287008007 PAS fold; Region: PAS_3; pfam08447 1168287008008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1168287008009 putative active site [active] 1168287008010 heme pocket [chemical binding]; other site 1168287008011 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287008012 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1168287008013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168287008014 ABC transporter; Region: ABC_tran_2; pfam12848 1168287008015 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168287008016 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287008017 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287008018 active site 1168287008019 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1168287008020 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1168287008021 malonyl-CoA binding site [chemical binding]; other site 1168287008022 dimer interface [polypeptide binding]; other site 1168287008023 active site 1168287008024 product binding site; other site 1168287008025 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287008026 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1168287008027 active site 1168287008028 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1168287008029 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287008030 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287008031 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168287008032 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287008033 active site 1168287008034 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287008035 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1168287008036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287008037 Enoylreductase; Region: PKS_ER; smart00829 1168287008038 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1168287008039 NAD(P) binding site [chemical binding]; other site 1168287008040 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1168287008041 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287008042 putative NADP binding site [chemical binding]; other site 1168287008043 active site 1168287008044 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287008045 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1168287008046 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1168287008047 active site 1168287008048 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1168287008049 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1168287008050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287008051 Enoylreductase; Region: PKS_ER; smart00829 1168287008052 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1168287008053 NAD(P) binding site [chemical binding]; other site 1168287008054 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1168287008055 putative NADP binding site [chemical binding]; other site 1168287008056 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287008057 active site 1168287008058 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287008059 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1168287008060 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1168287008061 malonyl-CoA binding site [chemical binding]; other site 1168287008062 dimer interface [polypeptide binding]; other site 1168287008063 active site 1168287008064 product binding site; other site 1168287008065 argininosuccinate lyase; Provisional; Region: PRK00855 1168287008066 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1168287008067 active sites [active] 1168287008068 tetramer interface [polypeptide binding]; other site 1168287008069 argininosuccinate synthase; Provisional; Region: PRK13820 1168287008070 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1168287008071 ANP binding site [chemical binding]; other site 1168287008072 Substrate Binding Site II [chemical binding]; other site 1168287008073 Substrate Binding Site I [chemical binding]; other site 1168287008074 arginine repressor; Provisional; Region: PRK03341 1168287008075 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1168287008076 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1168287008077 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1168287008078 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1168287008079 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1168287008080 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1168287008081 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168287008082 inhibitor-cofactor binding pocket; inhibition site 1168287008083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287008084 catalytic residue [active] 1168287008085 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1168287008086 feedback inhibition sensing region; other site 1168287008087 homohexameric interface [polypeptide binding]; other site 1168287008088 nucleotide binding site [chemical binding]; other site 1168287008089 N-acetyl-L-glutamate binding site [chemical binding]; other site 1168287008090 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1168287008091 heterotetramer interface [polypeptide binding]; other site 1168287008092 active site pocket [active] 1168287008093 cleavage site 1168287008094 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1168287008095 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168287008096 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1168287008097 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1168287008098 putative tRNA-binding site [nucleotide binding]; other site 1168287008099 B3/4 domain; Region: B3_4; pfam03483 1168287008100 tRNA synthetase B5 domain; Region: B5; smart00874 1168287008101 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1168287008102 dimer interface [polypeptide binding]; other site 1168287008103 motif 1; other site 1168287008104 motif 3; other site 1168287008105 motif 2; other site 1168287008106 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1168287008107 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1168287008108 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1168287008109 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1168287008110 dimer interface [polypeptide binding]; other site 1168287008111 motif 1; other site 1168287008112 active site 1168287008113 motif 2; other site 1168287008114 motif 3; other site 1168287008115 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287008116 cyclase homology domain; Region: CHD; cd07302 1168287008117 nucleotidyl binding site; other site 1168287008118 metal binding site [ion binding]; metal-binding site 1168287008119 dimer interface [polypeptide binding]; other site 1168287008120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1168287008121 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168287008122 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1168287008123 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168287008124 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1168287008125 23S rRNA binding site [nucleotide binding]; other site 1168287008126 L21 binding site [polypeptide binding]; other site 1168287008127 L13 binding site [polypeptide binding]; other site 1168287008128 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1168287008129 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1168287008130 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1168287008131 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1168287008132 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1168287008133 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1168287008134 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1168287008135 dimer interface [polypeptide binding]; other site 1168287008136 putative anticodon binding site; other site 1168287008137 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168287008138 motif 1; other site 1168287008139 dimer interface [polypeptide binding]; other site 1168287008140 active site 1168287008141 motif 2; other site 1168287008142 motif 3; other site 1168287008143 Predicted esterase [General function prediction only]; Region: COG0627 1168287008144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287008145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287008146 hypothetical protein; Provisional; Region: PRK07877 1168287008147 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1168287008148 ATP binding site [chemical binding]; other site 1168287008149 substrate interface [chemical binding]; other site 1168287008150 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1168287008151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1168287008152 metal binding site [ion binding]; metal-binding site 1168287008153 active site 1168287008154 I-site; other site 1168287008155 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1168287008156 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1168287008157 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1168287008158 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168287008159 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168287008160 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1168287008161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287008162 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168287008163 Ligand Binding Site [chemical binding]; other site 1168287008164 Predicted membrane protein [Function unknown]; Region: COG5305 1168287008165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287008166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168287008167 putative substrate translocation pore; other site 1168287008168 excinuclease ABC subunit B; Provisional; Region: PRK05298 1168287008169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287008170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287008171 nucleotide binding region [chemical binding]; other site 1168287008172 ATP-binding site [chemical binding]; other site 1168287008173 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1168287008174 UvrB/uvrC motif; Region: UVR; pfam02151 1168287008175 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287008176 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1168287008177 active site 1168287008178 ATP binding site [chemical binding]; other site 1168287008179 substrate binding site [chemical binding]; other site 1168287008180 activation loop (A-loop); other site 1168287008181 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287008182 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287008183 phosphopeptide binding site; other site 1168287008184 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287008185 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287008186 phosphopeptide binding site; other site 1168287008187 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168287008188 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1168287008189 Walker A/P-loop; other site 1168287008190 ATP binding site [chemical binding]; other site 1168287008191 Q-loop/lid; other site 1168287008192 ABC transporter signature motif; other site 1168287008193 Walker B; other site 1168287008194 D-loop; other site 1168287008195 H-loop/switch region; other site 1168287008196 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1168287008197 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1168287008198 Protein of unknown function (DUF402); Region: DUF402; cl00979 1168287008199 CheB methylesterase; Region: CheB_methylest; pfam01339 1168287008200 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1168287008201 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1168287008202 active site 1168287008203 DNA binding site [nucleotide binding] 1168287008204 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1168287008205 DNA binding site [nucleotide binding] 1168287008206 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1168287008207 nucleotide binding site [chemical binding]; other site 1168287008208 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1168287008209 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 1168287008210 DNA binding site [nucleotide binding] 1168287008211 catalytic residue [active] 1168287008212 H2TH interface [polypeptide binding]; other site 1168287008213 putative catalytic residues [active] 1168287008214 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168287008215 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1168287008216 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1168287008217 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1168287008218 CoA-binding site [chemical binding]; other site 1168287008219 ATP-binding [chemical binding]; other site 1168287008220 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1168287008221 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1168287008222 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1168287008223 RNA binding site [nucleotide binding]; other site 1168287008224 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1168287008225 RNA binding site [nucleotide binding]; other site 1168287008226 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1168287008227 RNA binding site [nucleotide binding]; other site 1168287008228 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1168287008229 RNA binding site [nucleotide binding]; other site 1168287008230 potential frameshift: common BLAST hit: gi|118463937|ref|YP_882337.1| retinal pigment epithelial membrane protein 1168287008231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287008232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287008233 5'-3' exonuclease; Region: 53EXOc; smart00475 1168287008234 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1168287008235 active site 1168287008236 metal binding site 1 [ion binding]; metal-binding site 1168287008237 putative 5' ssDNA interaction site; other site 1168287008238 metal binding site 3; metal-binding site 1168287008239 metal binding site 2 [ion binding]; metal-binding site 1168287008240 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1168287008241 putative DNA binding site [nucleotide binding]; other site 1168287008242 putative metal binding site [ion binding]; other site 1168287008243 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1168287008244 DNA polymerase I; Provisional; Region: PRK05755 1168287008245 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1168287008246 active site 1168287008247 DNA binding site [nucleotide binding] 1168287008248 catalytic site [active] 1168287008249 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1168287008250 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287008251 lipid-transfer protein; Provisional; Region: PRK06059 1168287008252 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287008253 active site 1168287008254 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1168287008255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287008256 active site 1168287008257 phosphorylation site [posttranslational modification] 1168287008258 intermolecular recognition site; other site 1168287008259 dimerization interface [polypeptide binding]; other site 1168287008260 ANTAR domain; Region: ANTAR; pfam03861 1168287008261 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1168287008262 cyclase homology domain; Region: CHD; cd07302 1168287008263 nucleotidyl binding site; other site 1168287008264 metal binding site [ion binding]; metal-binding site 1168287008265 dimer interface [polypeptide binding]; other site 1168287008266 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1168287008267 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1168287008268 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1168287008269 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1168287008270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287008271 Walker A/P-loop; other site 1168287008272 ATP binding site [chemical binding]; other site 1168287008273 ABC transporter; Region: ABC_tran; pfam00005 1168287008274 Q-loop/lid; other site 1168287008275 ABC transporter signature motif; other site 1168287008276 Walker B; other site 1168287008277 D-loop; other site 1168287008278 H-loop/switch region; other site 1168287008279 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1168287008280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287008281 Walker A/P-loop; other site 1168287008282 ATP binding site [chemical binding]; other site 1168287008283 Q-loop/lid; other site 1168287008284 ABC transporter signature motif; other site 1168287008285 Walker B; other site 1168287008286 D-loop; other site 1168287008287 H-loop/switch region; other site 1168287008288 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1168287008289 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1168287008290 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1168287008291 active site 1168287008292 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1168287008293 catalytic triad [active] 1168287008294 dimer interface [polypeptide binding]; other site 1168287008295 pyruvate kinase; Provisional; Region: PRK06247 1168287008296 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1168287008297 domain interfaces; other site 1168287008298 active site 1168287008299 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1168287008300 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1168287008301 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1168287008302 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1168287008303 substrate binding site [chemical binding]; other site 1168287008304 active site 1168287008305 catalytic residues [active] 1168287008306 heterodimer interface [polypeptide binding]; other site 1168287008307 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1168287008308 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1168287008309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287008310 catalytic residue [active] 1168287008311 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1168287008312 active site 1168287008313 ribulose/triose binding site [chemical binding]; other site 1168287008314 phosphate binding site [ion binding]; other site 1168287008315 substrate (anthranilate) binding pocket [chemical binding]; other site 1168287008316 product (indole) binding pocket [chemical binding]; other site 1168287008317 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1168287008318 anthranilate synthase component I; Provisional; Region: PRK13571 1168287008319 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1168287008320 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1168287008321 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1168287008322 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1168287008323 catalytic triad [active] 1168287008324 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1168287008325 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1168287008326 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1168287008327 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1168287008328 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1168287008329 substrate binding site [chemical binding]; other site 1168287008330 glutamase interaction surface [polypeptide binding]; other site 1168287008331 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168287008332 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1168287008333 active site 1168287008334 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1168287008335 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1168287008336 catalytic residues [active] 1168287008337 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1168287008338 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1168287008339 putative active site [active] 1168287008340 oxyanion strand; other site 1168287008341 catalytic triad [active] 1168287008342 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1168287008343 putative active site pocket [active] 1168287008344 4-fold oligomerization interface [polypeptide binding]; other site 1168287008345 metal binding residues [ion binding]; metal-binding site 1168287008346 3-fold/trimer interface [polypeptide binding]; other site 1168287008347 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1168287008348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287008349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287008350 homodimer interface [polypeptide binding]; other site 1168287008351 catalytic residue [active] 1168287008352 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1168287008353 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1168287008354 NAD binding site [chemical binding]; other site 1168287008355 dimerization interface [polypeptide binding]; other site 1168287008356 product binding site; other site 1168287008357 substrate binding site [chemical binding]; other site 1168287008358 zinc binding site [ion binding]; other site 1168287008359 catalytic residues [active] 1168287008360 Domain of unknown function (DUF385); Region: DUF385; cl04387 1168287008361 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1168287008362 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1168287008363 dimerization interface [polypeptide binding]; other site 1168287008364 active site 1168287008365 L-aspartate oxidase; Provisional; Region: PRK07804 1168287008366 L-aspartate oxidase; Provisional; Region: PRK06175 1168287008367 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1168287008368 quinolinate synthetase; Provisional; Region: PRK09375 1168287008369 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1168287008370 nudix motif; other site 1168287008371 Secretory lipase; Region: LIP; pfam03583 1168287008372 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1168287008373 biotin synthase; Validated; Region: PRK06256 1168287008374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287008375 FeS/SAM binding site; other site 1168287008376 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1168287008377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168287008378 dimerization interface [polypeptide binding]; other site 1168287008379 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1168287008380 cyclase homology domain; Region: CHD; cd07302 1168287008381 nucleotidyl binding site; other site 1168287008382 metal binding site [ion binding]; metal-binding site 1168287008383 dimer interface [polypeptide binding]; other site 1168287008384 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1168287008385 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1168287008386 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168287008387 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168287008388 ligand binding site [chemical binding]; other site 1168287008389 flexible hinge region; other site 1168287008390 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1168287008391 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1168287008392 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1168287008393 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1168287008394 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1168287008395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287008396 catalytic residue [active] 1168287008397 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1168287008398 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168287008399 inhibitor-cofactor binding pocket; inhibition site 1168287008400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287008401 catalytic residue [active] 1168287008402 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168287008403 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168287008404 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287008405 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1168287008406 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1168287008407 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1168287008408 active site 1168287008409 catalytic site [active] 1168287008410 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1168287008411 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1168287008412 active site 1168287008413 catalytic site [active] 1168287008414 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1168287008415 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1168287008416 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1168287008417 catalytic site [active] 1168287008418 active site 1168287008419 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1168287008420 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1168287008421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287008422 DNA-binding site [nucleotide binding]; DNA binding site 1168287008423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287008424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287008425 homodimer interface [polypeptide binding]; other site 1168287008426 catalytic residue [active] 1168287008427 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1168287008428 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1168287008429 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1168287008430 active site 1168287008431 threonine dehydratase; Validated; Region: PRK08639 1168287008432 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1168287008433 tetramer interface [polypeptide binding]; other site 1168287008434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287008435 catalytic residue [active] 1168287008436 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1168287008437 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287008438 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1168287008439 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1168287008440 putative acyl-acceptor binding pocket; other site 1168287008441 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168287008442 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1168287008443 acyl-activating enzyme (AAE) consensus motif; other site 1168287008444 putative AMP binding site [chemical binding]; other site 1168287008445 putative active site [active] 1168287008446 putative CoA binding site [chemical binding]; other site 1168287008447 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287008448 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1168287008449 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1168287008450 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1168287008451 DNA binding residues [nucleotide binding] 1168287008452 putative dimer interface [polypeptide binding]; other site 1168287008453 putative metal binding residues [ion binding]; other site 1168287008454 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1168287008455 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1168287008456 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1168287008457 active site 1168287008458 PHP Thumb interface [polypeptide binding]; other site 1168287008459 metal binding site [ion binding]; metal-binding site 1168287008460 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1168287008461 generic binding surface II; other site 1168287008462 generic binding surface I; other site 1168287008463 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287008464 hydrophobic ligand binding site; other site 1168287008465 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168287008466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287008467 NAD(P) binding site [chemical binding]; other site 1168287008468 active site 1168287008469 classical (c) SDRs; Region: SDR_c; cd05233 1168287008470 NAD(P) binding site [chemical binding]; other site 1168287008471 active site 1168287008472 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1168287008473 apolar tunnel; other site 1168287008474 heme binding site [chemical binding]; other site 1168287008475 dimerization interface [polypeptide binding]; other site 1168287008476 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1168287008477 S-adenosylmethionine binding site [chemical binding]; other site 1168287008478 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1168287008479 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1168287008480 active site 1168287008481 lipoprotein signal peptidase; Provisional; Region: PRK14764 1168287008482 lipoprotein signal peptidase; Provisional; Region: PRK14787 1168287008483 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1168287008484 active site 1168287008485 homodimer interface [polypeptide binding]; other site 1168287008486 homotetramer interface [polypeptide binding]; other site 1168287008487 DNA polymerase IV; Provisional; Region: PRK03348 1168287008488 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1168287008489 active site 1168287008490 DNA binding site [nucleotide binding] 1168287008491 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1168287008492 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1168287008493 HIGH motif; other site 1168287008494 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1168287008495 active site 1168287008496 KMSKS motif; other site 1168287008497 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1168287008498 tRNA binding surface [nucleotide binding]; other site 1168287008499 anticodon binding site; other site 1168287008500 Nitronate monooxygenase; Region: NMO; pfam03060 1168287008501 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287008502 FMN binding site [chemical binding]; other site 1168287008503 substrate binding site [chemical binding]; other site 1168287008504 putative catalytic residue [active] 1168287008505 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287008506 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287008507 Condensation domain; Region: Condensation; pfam00668 1168287008508 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008509 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287008510 acyl-activating enzyme (AAE) consensus motif; other site 1168287008511 AMP binding site [chemical binding]; other site 1168287008512 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008513 Condensation domain; Region: Condensation; pfam00668 1168287008514 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287008515 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008516 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008517 acyl-activating enzyme (AAE) consensus motif; other site 1168287008518 AMP binding site [chemical binding]; other site 1168287008519 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008520 peptide synthase; Provisional; Region: PRK12467 1168287008521 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008522 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008523 acyl-activating enzyme (AAE) consensus motif; other site 1168287008524 AMP binding site [chemical binding]; other site 1168287008525 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008526 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008527 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008528 acyl-activating enzyme (AAE) consensus motif; other site 1168287008529 AMP binding site [chemical binding]; other site 1168287008530 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008531 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287008532 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008533 acyl-activating enzyme (AAE) consensus motif; other site 1168287008534 AMP binding site [chemical binding]; other site 1168287008535 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008536 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287008537 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008538 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008539 acyl-activating enzyme (AAE) consensus motif; other site 1168287008540 AMP binding site [chemical binding]; other site 1168287008541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008542 Condensation domain; Region: Condensation; pfam00668 1168287008543 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287008544 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008545 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008546 acyl-activating enzyme (AAE) consensus motif; other site 1168287008547 AMP binding site [chemical binding]; other site 1168287008548 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008549 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1168287008550 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1168287008551 putative NAD(P) binding site [chemical binding]; other site 1168287008552 active site 1168287008553 putative substrate binding site [chemical binding]; other site 1168287008554 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008555 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287008556 acyl-activating enzyme (AAE) consensus motif; other site 1168287008557 AMP binding site [chemical binding]; other site 1168287008558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008559 Condensation domain; Region: Condensation; pfam00668 1168287008560 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287008561 Condensation domain; Region: Condensation; pfam00668 1168287008562 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287008563 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008564 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008565 acyl-activating enzyme (AAE) consensus motif; other site 1168287008566 AMP binding site [chemical binding]; other site 1168287008567 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008568 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1168287008569 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1168287008570 putative NAD(P) binding site [chemical binding]; other site 1168287008571 active site 1168287008572 putative substrate binding site [chemical binding]; other site 1168287008573 Condensation domain; Region: Condensation; pfam00668 1168287008574 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008575 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287008576 acyl-activating enzyme (AAE) consensus motif; other site 1168287008577 AMP binding site [chemical binding]; other site 1168287008578 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008579 Condensation domain; Region: Condensation; pfam00668 1168287008580 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287008581 Condensation domain; Region: Condensation; pfam00668 1168287008582 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287008583 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008584 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008585 acyl-activating enzyme (AAE) consensus motif; other site 1168287008586 AMP binding site [chemical binding]; other site 1168287008587 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008588 Condensation domain; Region: Condensation; pfam00668 1168287008589 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287008590 Condensation domain; Region: Condensation; pfam00668 1168287008591 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287008592 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008593 MbtH-like protein; Region: MbtH; pfam03621 1168287008594 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287008595 Transport protein; Region: actII; TIGR00833 1168287008596 Transport protein; Region: actII; TIGR00833 1168287008597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287008598 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1168287008599 Walker A/P-loop; other site 1168287008600 ATP binding site [chemical binding]; other site 1168287008601 Q-loop/lid; other site 1168287008602 ABC transporter signature motif; other site 1168287008603 Walker B; other site 1168287008604 D-loop; other site 1168287008605 H-loop/switch region; other site 1168287008606 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168287008607 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1168287008608 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1168287008609 daunorubicin resistance protein C; Region: drrC; TIGR01248 1168287008610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1168287008611 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1168287008612 metal-binding site 1168287008613 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1168287008614 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1168287008615 NADP binding site [chemical binding]; other site 1168287008616 active site 1168287008617 putative substrate binding site [chemical binding]; other site 1168287008618 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1168287008619 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1168287008620 NADP-binding site; other site 1168287008621 homotetramer interface [polypeptide binding]; other site 1168287008622 substrate binding site [chemical binding]; other site 1168287008623 homodimer interface [polypeptide binding]; other site 1168287008624 active site 1168287008625 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1168287008626 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1168287008627 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1168287008628 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1168287008629 classical (c) SDRs; Region: SDR_c; cd05233 1168287008630 NAD(P) binding site [chemical binding]; other site 1168287008631 active site 1168287008632 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1168287008633 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1168287008634 putative ligand binding site [chemical binding]; other site 1168287008635 putative NAD binding site [chemical binding]; other site 1168287008636 catalytic site [active] 1168287008637 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1168287008638 ligand binding site; other site 1168287008639 tetramer interface; other site 1168287008640 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1168287008641 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168287008642 active site 1168287008643 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1168287008644 Strictosidine synthase; Region: Str_synth; pfam03088 1168287008645 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1168287008646 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1168287008647 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1168287008648 homodimer interface [polypeptide binding]; other site 1168287008649 active site 1168287008650 TDP-binding site; other site 1168287008651 acceptor substrate-binding pocket; other site 1168287008652 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168287008653 classical (c) SDRs; Region: SDR_c; cd05233 1168287008654 NAD(P) binding site [chemical binding]; other site 1168287008655 active site 1168287008656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287008657 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 1168287008658 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1168287008659 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1168287008660 homodimer interface [polypeptide binding]; other site 1168287008661 active site 1168287008662 TDP-binding site; other site 1168287008663 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1168287008664 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1168287008665 active site 1168287008666 TDP-binding site; other site 1168287008667 acceptor substrate-binding pocket; other site 1168287008668 homodimer interface [polypeptide binding]; other site 1168287008669 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 1168287008670 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287008671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287008672 NAD(P) binding site [chemical binding]; other site 1168287008673 active site 1168287008674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1168287008675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287008676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1168287008677 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287008678 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287008679 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287008680 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1168287008681 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1168287008682 Walker A; other site 1168287008683 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1168287008684 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1168287008685 active site 1168287008686 substrate binding site [chemical binding]; other site 1168287008687 coenzyme B12 binding site [chemical binding]; other site 1168287008688 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1168287008689 B12 binding site [chemical binding]; other site 1168287008690 cobalt ligand [ion binding]; other site 1168287008691 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1168287008692 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1168287008693 heterodimer interface [polypeptide binding]; other site 1168287008694 substrate interaction site [chemical binding]; other site 1168287008695 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1168287008696 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1168287008697 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1168287008698 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1168287008699 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1168287008700 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1168287008701 putative di-iron ligands [ion binding]; other site 1168287008702 MbtH-like protein; Region: MbtH; cl01279 1168287008703 Condensation domain; Region: Condensation; pfam00668 1168287008704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008705 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287008706 acyl-activating enzyme (AAE) consensus motif; other site 1168287008707 AMP binding site [chemical binding]; other site 1168287008708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008709 Condensation domain; Region: Condensation; pfam00668 1168287008710 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287008711 Condensation domain; Region: Condensation; pfam00668 1168287008712 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008713 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1168287008714 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1168287008715 acyl-activating enzyme (AAE) consensus motif; other site 1168287008716 AMP binding site [chemical binding]; other site 1168287008717 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287008718 Condensation domain; Region: Condensation; pfam00668 1168287008719 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1168287008720 Condensation domain; Region: Condensation; pfam00668 1168287008721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1168287008722 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1168287008723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287008724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287008725 dimer interface [polypeptide binding]; other site 1168287008726 phosphorylation site [posttranslational modification] 1168287008727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287008728 Mg2+ binding site [ion binding]; other site 1168287008729 G-X-G motif; other site 1168287008730 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287008731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287008732 active site 1168287008733 phosphorylation site [posttranslational modification] 1168287008734 intermolecular recognition site; other site 1168287008735 dimerization interface [polypeptide binding]; other site 1168287008736 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287008737 DNA binding site [nucleotide binding] 1168287008738 Domain of unknown function (DUF385); Region: DUF385; cl04387 1168287008739 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1168287008740 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1168287008741 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1168287008742 ferrochelatase; Reviewed; Region: hemH; PRK00035 1168287008743 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1168287008744 C-terminal domain interface [polypeptide binding]; other site 1168287008745 active site 1168287008746 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1168287008747 active site 1168287008748 N-terminal domain interface [polypeptide binding]; other site 1168287008749 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1168287008750 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1168287008751 NAD binding site [chemical binding]; other site 1168287008752 homotetramer interface [polypeptide binding]; other site 1168287008753 homodimer interface [polypeptide binding]; other site 1168287008754 substrate binding site [chemical binding]; other site 1168287008755 active site 1168287008756 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1168287008757 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1168287008758 NAD(P) binding site [chemical binding]; other site 1168287008759 homotetramer interface [polypeptide binding]; other site 1168287008760 homodimer interface [polypeptide binding]; other site 1168287008761 active site 1168287008762 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287008763 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287008764 Integrase core domain; Region: rve; pfam00665 1168287008765 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287008766 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287008767 Integrase core domain; Region: rve; pfam00665 1168287008768 hypothetical protein; Provisional; Region: PRK13685 1168287008769 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1168287008770 metal ion-dependent adhesion site (MIDAS); other site 1168287008771 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1168287008772 Protein of unknown function DUF58; Region: DUF58; pfam01882 1168287008773 MoxR-like ATPases [General function prediction only]; Region: COG0714 1168287008774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287008775 Walker A motif; other site 1168287008776 ATP binding site [chemical binding]; other site 1168287008777 Walker B motif; other site 1168287008778 arginine finger; other site 1168287008779 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168287008780 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168287008781 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168287008782 NlpC/P60 family; Region: NLPC_P60; pfam00877 1168287008783 aconitate hydratase; Validated; Region: PRK09277 1168287008784 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1168287008785 substrate binding site [chemical binding]; other site 1168287008786 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1168287008787 ligand binding site [chemical binding]; other site 1168287008788 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1168287008789 substrate binding site [chemical binding]; other site 1168287008790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287008791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287008792 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1168287008793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287008794 Walker A/P-loop; other site 1168287008795 ATP binding site [chemical binding]; other site 1168287008796 Q-loop/lid; other site 1168287008797 ABC transporter signature motif; other site 1168287008798 Walker B; other site 1168287008799 D-loop; other site 1168287008800 H-loop/switch region; other site 1168287008801 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168287008802 enoyl-CoA hydratase; Provisional; Region: PRK05864 1168287008803 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287008804 substrate binding site [chemical binding]; other site 1168287008805 oxyanion hole (OAH) forming residues; other site 1168287008806 trimer interface [polypeptide binding]; other site 1168287008807 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1168287008808 catalytic residues [active] 1168287008809 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1168287008810 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1168287008811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287008812 active site 1168287008813 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1168287008814 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1168287008815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287008816 NAD(P) binding site [chemical binding]; other site 1168287008817 active site 1168287008818 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1168287008819 homotrimer interaction site [polypeptide binding]; other site 1168287008820 putative active site [active] 1168287008821 Cupin domain; Region: Cupin_2; pfam07883 1168287008822 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1168287008823 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287008824 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1168287008825 dimer interface [polypeptide binding]; other site 1168287008826 active site 1168287008827 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1168287008828 classical (c) SDRs; Region: SDR_c; cd05233 1168287008829 NAD(P) binding site [chemical binding]; other site 1168287008830 active site 1168287008831 Transport protein; Region: actII; TIGR00833 1168287008832 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287008833 O-methyltransferase; Region: Methyltransf_2; pfam00891 1168287008834 potential frameshift: common BLAST hit: gi|379762677|ref|YP_005349074.1| transmembrane efflux pump 1168287008835 Nitroreductase family; Region: Nitroreductase; pfam00881 1168287008836 FMN binding site [chemical binding]; other site 1168287008837 dimer interface [polypeptide binding]; other site 1168287008838 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1168287008839 homotrimer interaction site [polypeptide binding]; other site 1168287008840 putative active site [active] 1168287008841 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1168287008842 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168287008843 putative NAD(P) binding site [chemical binding]; other site 1168287008844 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1168287008845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287008846 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287008847 Cupin domain; Region: Cupin_2; cl17218 1168287008848 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168287008849 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1168287008850 putative NAD(P) binding site [chemical binding]; other site 1168287008851 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287008852 PPE family; Region: PPE; pfam00823 1168287008853 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287008854 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287008855 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1168287008856 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1168287008857 GAF domain; Region: GAF; cl17456 1168287008858 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1168287008859 DNA-binding interface [nucleotide binding]; DNA binding site 1168287008860 AAA ATPase domain; Region: AAA_16; pfam13191 1168287008861 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287008862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287008863 DNA binding residues [nucleotide binding] 1168287008864 dimerization interface [polypeptide binding]; other site 1168287008865 AAA ATPase domain; Region: AAA_16; pfam13191 1168287008866 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287008867 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287008868 DNA binding residues [nucleotide binding] 1168287008869 dimerization interface [polypeptide binding]; other site 1168287008870 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1168287008871 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287008872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287008873 DNA binding residues [nucleotide binding] 1168287008874 dimerization interface [polypeptide binding]; other site 1168287008875 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1168287008876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287008877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287008878 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287008879 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1168287008880 putative active site [active] 1168287008881 transaldolase; Provisional; Region: PRK03903 1168287008882 catalytic residue [active] 1168287008883 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1168287008884 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1168287008885 Moco binding site; other site 1168287008886 metal coordination site [ion binding]; other site 1168287008887 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1168287008888 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 1168287008889 FAD binding pocket [chemical binding]; other site 1168287008890 FAD binding motif [chemical binding]; other site 1168287008891 phosphate binding motif [ion binding]; other site 1168287008892 beta-alpha-beta structure motif; other site 1168287008893 NAD binding pocket [chemical binding]; other site 1168287008894 DNL zinc finger; Region: zf-DNL; pfam05180 1168287008895 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1168287008896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1168287008897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168287008898 Protein of unknown function, DUF417; Region: DUF417; cl01162 1168287008899 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1168287008900 classical (c) SDRs; Region: SDR_c; cd05233 1168287008901 NAD(P) binding site [chemical binding]; other site 1168287008902 active site 1168287008903 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1168287008904 SelR domain; Region: SelR; pfam01641 1168287008905 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1168287008906 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1168287008907 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1168287008908 D-pathway; other site 1168287008909 Putative ubiquinol binding site [chemical binding]; other site 1168287008910 Low-spin heme (heme b) binding site [chemical binding]; other site 1168287008911 Putative water exit pathway; other site 1168287008912 Binuclear center (heme o3/CuB) [ion binding]; other site 1168287008913 K-pathway; other site 1168287008914 Putative proton exit pathway; other site 1168287008915 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1168287008916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287008917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287008918 Predicted membrane protein [Function unknown]; Region: COG2323 1168287008919 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1168287008920 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1168287008921 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1168287008922 trimerization site [polypeptide binding]; other site 1168287008923 active site 1168287008924 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1168287008925 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1168287008926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287008927 catalytic residue [active] 1168287008928 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1168287008929 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1168287008930 Walker A/P-loop; other site 1168287008931 ATP binding site [chemical binding]; other site 1168287008932 Q-loop/lid; other site 1168287008933 ABC transporter signature motif; other site 1168287008934 Walker B; other site 1168287008935 D-loop; other site 1168287008936 H-loop/switch region; other site 1168287008937 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1168287008938 FeS assembly protein SufD; Region: sufD; TIGR01981 1168287008939 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1168287008940 FeS assembly protein SufB; Region: sufB; TIGR01980 1168287008941 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168287008942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287008943 putative DNA binding site [nucleotide binding]; other site 1168287008944 putative Zn2+ binding site [ion binding]; other site 1168287008945 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1168287008946 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1168287008947 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168287008948 Walker A/P-loop; other site 1168287008949 ATP binding site [chemical binding]; other site 1168287008950 Q-loop/lid; other site 1168287008951 ABC transporter signature motif; other site 1168287008952 Walker B; other site 1168287008953 D-loop; other site 1168287008954 H-loop/switch region; other site 1168287008955 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168287008956 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1168287008957 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1168287008958 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1168287008959 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1168287008960 NADP binding site [chemical binding]; other site 1168287008961 dimer interface [polypeptide binding]; other site 1168287008962 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1168287008963 UbiA prenyltransferase family; Region: UbiA; pfam01040 1168287008964 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1168287008965 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1168287008966 TPP-binding site [chemical binding]; other site 1168287008967 dimer interface [polypeptide binding]; other site 1168287008968 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1168287008969 PYR/PP interface [polypeptide binding]; other site 1168287008970 dimer interface [polypeptide binding]; other site 1168287008971 TPP binding site [chemical binding]; other site 1168287008972 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168287008973 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1168287008974 putative active site [active] 1168287008975 transaldolase; Provisional; Region: PRK03903 1168287008976 catalytic residue [active] 1168287008977 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1168287008978 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1168287008979 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1168287008980 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1168287008981 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1168287008982 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1168287008983 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1168287008984 putative active site [active] 1168287008985 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1168287008986 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1168287008987 putative active site [active] 1168287008988 Zn binding site [ion binding]; other site 1168287008989 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287008990 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287008991 active site 1168287008992 catalytic tetrad [active] 1168287008993 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1168287008994 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1168287008995 Preprotein translocase SecG subunit; Region: SecG; cl09123 1168287008996 triosephosphate isomerase; Provisional; Region: PRK14567 1168287008997 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1168287008998 substrate binding site [chemical binding]; other site 1168287008999 dimer interface [polypeptide binding]; other site 1168287009000 catalytic triad [active] 1168287009001 Phosphoglycerate kinase; Region: PGK; pfam00162 1168287009002 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1168287009003 substrate binding site [chemical binding]; other site 1168287009004 hinge regions; other site 1168287009005 ADP binding site [chemical binding]; other site 1168287009006 catalytic site [active] 1168287009007 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1168287009008 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1168287009009 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1168287009010 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287009011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287009012 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1168287009013 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287009014 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1168287009015 putative acyl-acceptor binding pocket; other site 1168287009016 acyl-CoA synthetase; Provisional; Region: PRK13382 1168287009017 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287009018 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287009019 acyl-activating enzyme (AAE) consensus motif; other site 1168287009020 putative AMP binding site [chemical binding]; other site 1168287009021 putative active site [active] 1168287009022 putative CoA binding site [chemical binding]; other site 1168287009023 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1168287009024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287009025 substrate binding pocket [chemical binding]; other site 1168287009026 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287009027 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287009028 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287009029 active site 1168287009030 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287009031 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287009032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1168287009033 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1168287009034 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1168287009035 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1168287009036 phosphate binding site [ion binding]; other site 1168287009037 putative substrate binding pocket [chemical binding]; other site 1168287009038 dimer interface [polypeptide binding]; other site 1168287009039 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1168287009040 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1168287009041 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1168287009042 GIY-YIG motif/motif A; other site 1168287009043 active site 1168287009044 catalytic site [active] 1168287009045 putative DNA binding site [nucleotide binding]; other site 1168287009046 metal binding site [ion binding]; metal-binding site 1168287009047 UvrB/uvrC motif; Region: UVR; pfam02151 1168287009048 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1168287009049 Helix-hairpin-helix motif; Region: HHH; pfam00633 1168287009050 Cupin superfamily protein; Region: Cupin_4; pfam08007 1168287009051 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287009052 PPE family; Region: PPE; pfam00823 1168287009053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1168287009054 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1168287009055 homopentamer interface [polypeptide binding]; other site 1168287009056 active site 1168287009057 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1168287009058 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1168287009059 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1168287009060 dimerization interface [polypeptide binding]; other site 1168287009061 active site 1168287009062 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1168287009063 Lumazine binding domain; Region: Lum_binding; pfam00677 1168287009064 Lumazine binding domain; Region: Lum_binding; pfam00677 1168287009065 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1168287009066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287009067 putative substrate translocation pore; other site 1168287009068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287009069 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1168287009070 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1168287009071 catalytic motif [active] 1168287009072 Zn binding site [ion binding]; other site 1168287009073 RibD C-terminal domain; Region: RibD_C; pfam01872 1168287009074 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1168287009075 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1168287009076 substrate binding site [chemical binding]; other site 1168287009077 hexamer interface [polypeptide binding]; other site 1168287009078 metal binding site [ion binding]; metal-binding site 1168287009079 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1168287009080 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1168287009081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287009082 S-adenosylmethionine binding site [chemical binding]; other site 1168287009083 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1168287009084 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1168287009085 putative active site [active] 1168287009086 substrate binding site [chemical binding]; other site 1168287009087 putative cosubstrate binding site; other site 1168287009088 catalytic site [active] 1168287009089 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1168287009090 substrate binding site [chemical binding]; other site 1168287009091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287009092 S-adenosylmethionine binding site [chemical binding]; other site 1168287009093 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287009094 MarR family; Region: MarR; pfam01047 1168287009095 primosome assembly protein PriA; Provisional; Region: PRK14873 1168287009096 YhhN-like protein; Region: YhhN; pfam07947 1168287009097 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287009098 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287009099 substrate binding pocket [chemical binding]; other site 1168287009100 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287009101 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287009102 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1168287009103 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1168287009104 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1168287009105 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1168287009106 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1168287009107 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1168287009108 Flavoprotein; Region: Flavoprotein; pfam02441 1168287009109 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1168287009110 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1168287009111 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1168287009112 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1168287009113 catalytic site [active] 1168287009114 G-X2-G-X-G-K; other site 1168287009115 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1168287009116 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168287009117 DNA binding residues [nucleotide binding] 1168287009118 TOBE domain; Region: TOBE; cl01440 1168287009119 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1168287009120 active site 1168287009121 dimer interface [polypeptide binding]; other site 1168287009122 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1168287009123 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168287009124 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287009125 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1168287009126 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168287009127 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287009128 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1168287009129 IMP binding site; other site 1168287009130 dimer interface [polypeptide binding]; other site 1168287009131 interdomain contacts; other site 1168287009132 partial ornithine binding site; other site 1168287009133 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1168287009134 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1168287009135 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1168287009136 catalytic site [active] 1168287009137 subunit interface [polypeptide binding]; other site 1168287009138 dihydroorotase; Validated; Region: pyrC; PRK09357 1168287009139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287009140 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1168287009141 active site 1168287009142 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1168287009143 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1168287009144 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1168287009145 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1168287009146 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1168287009147 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287009148 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287009149 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1168287009150 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168287009151 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1168287009152 L-aspartate oxidase; Provisional; Region: PRK06175 1168287009153 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1168287009154 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1168287009155 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1168287009156 Walker A/P-loop; other site 1168287009157 ATP binding site [chemical binding]; other site 1168287009158 Q-loop/lid; other site 1168287009159 ABC transporter signature motif; other site 1168287009160 Walker B; other site 1168287009161 D-loop; other site 1168287009162 H-loop/switch region; other site 1168287009163 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1168287009164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287009165 dimer interface [polypeptide binding]; other site 1168287009166 conserved gate region; other site 1168287009167 putative PBP binding loops; other site 1168287009168 ABC-ATPase subunit interface; other site 1168287009169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1168287009170 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1168287009171 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1168287009172 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1168287009173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287009174 DNA-binding site [nucleotide binding]; DNA binding site 1168287009175 UTRA domain; Region: UTRA; pfam07702 1168287009176 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1168287009177 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287009178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287009179 catalytic residue [active] 1168287009180 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1168287009181 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1168287009182 putative RNA binding site [nucleotide binding]; other site 1168287009183 elongation factor P; Validated; Region: PRK00529 1168287009184 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1168287009185 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1168287009186 RNA binding site [nucleotide binding]; other site 1168287009187 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1168287009188 RNA binding site [nucleotide binding]; other site 1168287009189 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1168287009190 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1168287009191 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1168287009192 active site 1168287009193 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1168287009194 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1168287009195 trimer interface [polypeptide binding]; other site 1168287009196 active site 1168287009197 dimer interface [polypeptide binding]; other site 1168287009198 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1168287009199 active site 1168287009200 dimer interface [polypeptide binding]; other site 1168287009201 metal binding site [ion binding]; metal-binding site 1168287009202 shikimate kinase; Reviewed; Region: aroK; PRK00131 1168287009203 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1168287009204 ADP binding site [chemical binding]; other site 1168287009205 magnesium binding site [ion binding]; other site 1168287009206 putative shikimate binding site; other site 1168287009207 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1168287009208 chorismate synthase; Validated; Region: PRK05382 1168287009209 Tetramer interface [polypeptide binding]; other site 1168287009210 active site 1168287009211 FMN-binding site [chemical binding]; other site 1168287009212 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1168287009213 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1168287009214 active site 1168287009215 dimer interface [polypeptide binding]; other site 1168287009216 non-prolyl cis peptide bond; other site 1168287009217 insertion regions; other site 1168287009218 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1168287009219 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1168287009220 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1168287009221 shikimate binding site; other site 1168287009222 NAD(P) binding site [chemical binding]; other site 1168287009223 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1168287009224 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1168287009225 dimerization interface [polypeptide binding]; other site 1168287009226 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1168287009227 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1168287009228 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1168287009229 motif 1; other site 1168287009230 active site 1168287009231 motif 2; other site 1168287009232 motif 3; other site 1168287009233 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1168287009234 DHHA1 domain; Region: DHHA1; pfam02272 1168287009235 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1168287009236 recombination factor protein RarA; Reviewed; Region: PRK13342 1168287009237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287009238 Walker A motif; other site 1168287009239 ATP binding site [chemical binding]; other site 1168287009240 Walker B motif; other site 1168287009241 arginine finger; other site 1168287009242 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1168287009243 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1168287009244 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1168287009245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1168287009246 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1168287009247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1168287009248 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1168287009249 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1168287009250 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1168287009251 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1168287009252 Protein of unknown function (DUF419); Region: DUF419; cl15265 1168287009253 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1168287009254 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287009255 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1168287009256 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1168287009257 dimer interface [polypeptide binding]; other site 1168287009258 anticodon binding site; other site 1168287009259 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1168287009260 homodimer interface [polypeptide binding]; other site 1168287009261 motif 1; other site 1168287009262 active site 1168287009263 motif 2; other site 1168287009264 GAD domain; Region: GAD; pfam02938 1168287009265 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168287009266 active site 1168287009267 motif 3; other site 1168287009268 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1168287009269 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1168287009270 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1168287009271 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1168287009272 putative hydrophobic ligand binding site [chemical binding]; other site 1168287009273 protein interface [polypeptide binding]; other site 1168287009274 gate; other site 1168287009275 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1168287009276 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1168287009277 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1168287009278 inhibitor site; inhibition site 1168287009279 active site 1168287009280 dimer interface [polypeptide binding]; other site 1168287009281 catalytic residue [active] 1168287009282 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1168287009283 intersubunit interface [polypeptide binding]; other site 1168287009284 active site 1168287009285 Zn2+ binding site [ion binding]; other site 1168287009286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287009287 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287009288 non-specific DNA binding site [nucleotide binding]; other site 1168287009289 salt bridge; other site 1168287009290 sequence-specific DNA binding site [nucleotide binding]; other site 1168287009291 Cupin domain; Region: Cupin_2; pfam07883 1168287009292 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1168287009293 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1168287009294 active site 1168287009295 metal binding site [ion binding]; metal-binding site 1168287009296 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1168287009297 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1168287009298 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287009299 hydrophobic ligand binding site; other site 1168287009300 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287009301 active site 1168287009302 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287009303 MULE transposase domain; Region: MULE; pfam10551 1168287009304 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287009305 Integrase core domain; Region: rve; pfam00665 1168287009306 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1168287009307 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1168287009308 dimer interface [polypeptide binding]; other site 1168287009309 motif 1; other site 1168287009310 active site 1168287009311 motif 2; other site 1168287009312 motif 3; other site 1168287009313 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1168287009314 anticodon binding site; other site 1168287009315 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1168287009316 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1168287009317 active site 1168287009318 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1168287009319 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168287009320 Zn2+ binding site [ion binding]; other site 1168287009321 Mg2+ binding site [ion binding]; other site 1168287009322 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1168287009323 synthetase active site [active] 1168287009324 NTP binding site [chemical binding]; other site 1168287009325 metal binding site [ion binding]; metal-binding site 1168287009326 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1168287009327 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1168287009328 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168287009329 active site 1168287009330 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1168287009331 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168287009332 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1168287009333 Protein export membrane protein; Region: SecD_SecF; pfam02355 1168287009334 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1168287009335 Protein export membrane protein; Region: SecD_SecF; cl14618 1168287009336 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1168287009337 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1168287009338 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168287009339 inhibitor-cofactor binding pocket; inhibition site 1168287009340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287009341 catalytic residue [active] 1168287009342 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168287009343 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287009344 acyl-activating enzyme (AAE) consensus motif; other site 1168287009345 AMP binding site [chemical binding]; other site 1168287009346 active site 1168287009347 CoA binding site [chemical binding]; other site 1168287009348 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1168287009349 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1168287009350 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1168287009351 putative NAD(P) binding site [chemical binding]; other site 1168287009352 active site 1168287009353 putative substrate binding site [chemical binding]; other site 1168287009354 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1168287009355 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1168287009356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287009357 Walker A motif; other site 1168287009358 ATP binding site [chemical binding]; other site 1168287009359 Walker B motif; other site 1168287009360 arginine finger; other site 1168287009361 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1168287009362 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1168287009363 RuvA N terminal domain; Region: RuvA_N; pfam01330 1168287009364 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1168287009365 active site 1168287009366 putative DNA-binding cleft [nucleotide binding]; other site 1168287009367 dimer interface [polypeptide binding]; other site 1168287009368 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1168287009369 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1168287009370 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1168287009371 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1168287009372 spermidine synthase; Provisional; Region: PRK03612 1168287009373 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1168287009374 hypothetical protein; Validated; Region: PRK00110 1168287009375 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1168287009376 predicted active site [active] 1168287009377 catalytic triad [active] 1168287009378 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1168287009379 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1168287009380 active site 1168287009381 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1168287009382 catalytic triad [active] 1168287009383 dimer interface [polypeptide binding]; other site 1168287009384 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1168287009385 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1168287009386 active site 1168287009387 multimer interface [polypeptide binding]; other site 1168287009388 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1168287009389 nudix motif; other site 1168287009390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287009391 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287009392 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1168287009393 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1168287009394 putative acyl-acceptor binding pocket; other site 1168287009395 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168287009396 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1168287009397 nucleotide binding site/active site [active] 1168287009398 HIT family signature motif; other site 1168287009399 catalytic residue [active] 1168287009400 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1168287009401 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1168287009402 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1168287009403 active site 1168287009404 dimer interface [polypeptide binding]; other site 1168287009405 motif 1; other site 1168287009406 motif 2; other site 1168287009407 motif 3; other site 1168287009408 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1168287009409 anticodon binding site; other site 1168287009410 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1168287009411 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1168287009412 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1168287009413 metal binding site [ion binding]; metal-binding site 1168287009414 putative dimer interface [polypeptide binding]; other site 1168287009415 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287009416 CoenzymeA binding site [chemical binding]; other site 1168287009417 subunit interaction site [polypeptide binding]; other site 1168287009418 PHB binding site; other site 1168287009419 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287009420 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287009421 active site 1168287009422 catalytic tetrad [active] 1168287009423 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1168287009424 Helix-turn-helix domain; Region: HTH_20; pfam12840 1168287009425 putative DNA binding site [nucleotide binding]; other site 1168287009426 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168287009427 putative Zn2+ binding site [ion binding]; other site 1168287009428 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287009429 FMN binding site [chemical binding]; other site 1168287009430 substrate binding site [chemical binding]; other site 1168287009431 putative catalytic residue [active] 1168287009432 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1168287009433 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168287009434 Helix-turn-helix domain; Region: HTH_20; pfam12840 1168287009435 putative DNA binding site [nucleotide binding]; other site 1168287009436 putative Zn2+ binding site [ion binding]; other site 1168287009437 Ferredoxin [Energy production and conversion]; Region: COG1146 1168287009438 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287009439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287009440 S-adenosylmethionine binding site [chemical binding]; other site 1168287009441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287009442 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1168287009443 tetramer interface [polypeptide binding]; other site 1168287009444 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1168287009445 active site 1168287009446 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1168287009447 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1168287009448 active site 1168287009449 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287009450 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1168287009451 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1168287009452 iron-sulfur cluster [ion binding]; other site 1168287009453 [2Fe-2S] cluster binding site [ion binding]; other site 1168287009454 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287009455 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 1168287009456 alpha subunit interaction site [polypeptide binding]; other site 1168287009457 beta subunit interaction site [polypeptide binding]; other site 1168287009458 iron-sulfur cluster [ion binding]; other site 1168287009459 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1168287009460 beta subunit interface [polypeptide binding]; other site 1168287009461 alpha subunit interface [polypeptide binding]; other site 1168287009462 active site 1168287009463 substrate binding site [chemical binding]; other site 1168287009464 Fe binding site [ion binding]; other site 1168287009465 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1168287009466 inter-subunit interface; other site 1168287009467 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1168287009468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287009469 NAD(P) binding site [chemical binding]; other site 1168287009470 active site 1168287009471 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1168287009472 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1168287009473 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168287009474 Bacterial transcriptional regulator; Region: IclR; pfam01614 1168287009475 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1168287009476 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1168287009477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287009478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287009479 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287009480 anti sigma factor interaction site; other site 1168287009481 regulatory phosphorylation site [posttranslational modification]; other site 1168287009482 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1168287009483 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1168287009484 Predicted permeases [General function prediction only]; Region: COG0730 1168287009485 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1168287009486 putative heme binding pocket [chemical binding]; other site 1168287009487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287009488 classical (c) SDRs; Region: SDR_c; cd05233 1168287009489 NAD(P) binding site [chemical binding]; other site 1168287009490 active site 1168287009491 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1168287009492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287009493 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287009494 acyl-activating enzyme (AAE) consensus motif; other site 1168287009495 acyl-activating enzyme (AAE) consensus motif; other site 1168287009496 putative AMP binding site [chemical binding]; other site 1168287009497 putative active site [active] 1168287009498 putative CoA binding site [chemical binding]; other site 1168287009499 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1168287009500 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287009501 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287009502 substrate binding site [chemical binding]; other site 1168287009503 oxyanion hole (OAH) forming residues; other site 1168287009504 trimer interface [polypeptide binding]; other site 1168287009505 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287009506 hydrophobic ligand binding site; other site 1168287009507 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1168287009508 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287009509 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287009510 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1168287009511 classical (c) SDRs; Region: SDR_c; cd05233 1168287009512 NAD(P) binding site [chemical binding]; other site 1168287009513 active site 1168287009514 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168287009515 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1168287009516 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287009517 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1168287009518 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287009519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287009520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287009521 short chain dehydrogenase; Provisional; Region: PRK12827 1168287009522 classical (c) SDRs; Region: SDR_c; cd05233 1168287009523 NAD(P) binding site [chemical binding]; other site 1168287009524 active site 1168287009525 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287009526 classical (c) SDRs; Region: SDR_c; cd05233 1168287009527 NAD(P) binding site [chemical binding]; other site 1168287009528 active site 1168287009529 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1168287009530 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1168287009531 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287009532 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287009533 NAD(P) binding site [chemical binding]; other site 1168287009534 catalytic residues [active] 1168287009535 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1168287009536 Cation efflux family; Region: Cation_efflux; cl00316 1168287009537 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287009538 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287009539 Clp amino terminal domain; Region: Clp_N; pfam02861 1168287009540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287009541 Coenzyme A binding pocket [chemical binding]; other site 1168287009542 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1168287009543 hypothetical protein; Provisional; Region: PRK14059 1168287009544 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1168287009545 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287009546 TAP-like protein; Region: Abhydrolase_4; pfam08386 1168287009547 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1168287009548 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1168287009549 SelR domain; Region: SelR; pfam01641 1168287009550 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1168287009551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287009552 S-adenosylmethionine binding site [chemical binding]; other site 1168287009553 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1168287009554 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1168287009555 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287009556 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1168287009557 substrate binding site [chemical binding]; other site 1168287009558 active site 1168287009559 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287009560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287009561 substrate binding site [chemical binding]; other site 1168287009562 oxyanion hole (OAH) forming residues; other site 1168287009563 trimer interface [polypeptide binding]; other site 1168287009564 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1168287009565 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1168287009566 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1168287009567 catalytic site [active] 1168287009568 putative active site [active] 1168287009569 putative substrate binding site [chemical binding]; other site 1168287009570 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1168287009571 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1168287009572 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1168287009573 TPP-binding site; other site 1168287009574 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1168287009575 PYR/PP interface [polypeptide binding]; other site 1168287009576 dimer interface [polypeptide binding]; other site 1168287009577 TPP binding site [chemical binding]; other site 1168287009578 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168287009579 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1168287009580 FOG: CBS domain [General function prediction only]; Region: COG0517 1168287009581 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1168287009582 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1168287009583 transmembrane helices; other site 1168287009584 TRAM domain; Region: TRAM; pfam01938 1168287009585 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1168287009586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287009587 NAD(P) binding site [chemical binding]; other site 1168287009588 active site 1168287009589 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1168287009590 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1168287009591 TrkA-N domain; Region: TrkA_N; pfam02254 1168287009592 TrkA-C domain; Region: TrkA_C; pfam02080 1168287009593 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1168287009594 TrkA-N domain; Region: TrkA_N; pfam02254 1168287009595 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1168287009596 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1168287009597 generic binding surface II; other site 1168287009598 ssDNA binding site; other site 1168287009599 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1168287009600 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1168287009601 trimer interface [polypeptide binding]; other site 1168287009602 active site 1168287009603 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1168287009604 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1168287009605 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168287009606 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1168287009607 active site 1168287009608 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168287009609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287009610 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1168287009611 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287009612 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1168287009613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287009614 DNA binding residues [nucleotide binding] 1168287009615 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1168287009616 homotrimer interaction site [polypeptide binding]; other site 1168287009617 putative active site [active] 1168287009618 Protein of unknown function (DUF952); Region: DUF952; cl01393 1168287009619 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1168287009620 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1168287009621 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1168287009622 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1168287009623 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1168287009624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287009625 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1168287009626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287009627 DNA binding residues [nucleotide binding] 1168287009628 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1168287009629 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1168287009630 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1168287009631 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1168287009632 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1168287009633 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1168287009634 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287009635 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287009636 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287009637 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168287009638 PAC2 family; Region: PAC2; pfam09754 1168287009639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287009640 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1168287009641 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1168287009642 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1168287009643 ATP cone domain; Region: ATP-cone; pfam03477 1168287009644 LexA repressor; Validated; Region: PRK00215 1168287009645 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1168287009646 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1168287009647 Catalytic site [active] 1168287009648 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1168287009649 LGFP repeat; Region: LGFP; pfam08310 1168287009650 LGFP repeat; Region: LGFP; pfam08310 1168287009651 LGFP repeat; Region: LGFP; pfam08310 1168287009652 LGFP repeat; Region: LGFP; pfam08310 1168287009653 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287009654 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287009655 active site 1168287009656 GTPases [General function prediction only]; Region: HflX; COG2262 1168287009657 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1168287009658 HflX GTPase family; Region: HflX; cd01878 1168287009659 G1 box; other site 1168287009660 GTP/Mg2+ binding site [chemical binding]; other site 1168287009661 Switch I region; other site 1168287009662 G2 box; other site 1168287009663 G3 box; other site 1168287009664 Switch II region; other site 1168287009665 G4 box; other site 1168287009666 G5 box; other site 1168287009667 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1168287009668 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1168287009669 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1168287009670 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1168287009671 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1168287009672 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1168287009673 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168287009674 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168287009675 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168287009676 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1168287009677 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1168287009678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287009679 FeS/SAM binding site; other site 1168287009680 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1168287009681 recombinase A; Provisional; Region: recA; PRK09354 1168287009682 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1168287009683 hexamer interface [polypeptide binding]; other site 1168287009684 Walker A motif; other site 1168287009685 ATP binding site [chemical binding]; other site 1168287009686 Walker B motif; other site 1168287009687 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1168287009688 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1168287009689 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168287009690 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1168287009691 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1168287009692 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1168287009693 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 1168287009694 PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674 1168287009695 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1168287009696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287009697 non-specific DNA binding site [nucleotide binding]; other site 1168287009698 salt bridge; other site 1168287009699 sequence-specific DNA binding site [nucleotide binding]; other site 1168287009700 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168287009701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287009702 Coenzyme A binding pocket [chemical binding]; other site 1168287009703 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1168287009704 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1168287009705 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287009706 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1168287009707 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1168287009708 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1168287009709 classical (c) SDRs; Region: SDR_c; cd05233 1168287009710 NAD(P) binding site [chemical binding]; other site 1168287009711 active site 1168287009712 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287009713 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287009714 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1168287009715 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287009716 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1168287009717 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1168287009718 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1168287009719 dimer interface [polypeptide binding]; other site 1168287009720 active site 1168287009721 catalytic residue [active] 1168287009722 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1168287009723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1168287009724 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1168287009725 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1168287009726 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1168287009727 folate binding site [chemical binding]; other site 1168287009728 NADP+ binding site [chemical binding]; other site 1168287009729 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1168287009730 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1168287009731 dimerization interface [polypeptide binding]; other site 1168287009732 active site 1168287009733 Dienelactone hydrolase family; Region: DLH; pfam01738 1168287009734 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287009735 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287009736 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287009737 active site 1168287009738 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287009739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287009740 active site 1168287009741 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1168287009742 classical (c) SDRs; Region: SDR_c; cd05233 1168287009743 NAD(P) binding site [chemical binding]; other site 1168287009744 active site 1168287009745 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1168287009746 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168287009747 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287009748 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168287009749 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1168287009750 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168287009751 carboxyltransferase (CT) interaction site; other site 1168287009752 biotinylation site [posttranslational modification]; other site 1168287009753 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168287009754 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287009755 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287009756 acyl-activating enzyme (AAE) consensus motif; other site 1168287009757 AMP binding site [chemical binding]; other site 1168287009758 active site 1168287009759 CoA binding site [chemical binding]; other site 1168287009760 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168287009761 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287009762 CoenzymeA binding site [chemical binding]; other site 1168287009763 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1168287009764 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168287009765 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1168287009766 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168287009767 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1168287009768 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287009769 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287009770 active site 1168287009771 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287009772 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168287009773 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287009774 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287009775 [2Fe-2S] cluster binding site [ion binding]; other site 1168287009776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287009777 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1168287009778 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1168287009779 FMN-binding pocket [chemical binding]; other site 1168287009780 flavin binding motif; other site 1168287009781 phosphate binding motif [ion binding]; other site 1168287009782 beta-alpha-beta structure motif; other site 1168287009783 NAD binding pocket [chemical binding]; other site 1168287009784 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287009785 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1168287009786 catalytic loop [active] 1168287009787 iron binding site [ion binding]; other site 1168287009788 short chain dehydrogenase; Validated; Region: PRK05855 1168287009789 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287009790 classical (c) SDRs; Region: SDR_c; cd05233 1168287009791 NAD(P) binding site [chemical binding]; other site 1168287009792 active site 1168287009793 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1168287009794 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1168287009795 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287009796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287009797 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287009798 hydrophobic ligand binding site; other site 1168287009799 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1168287009800 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1168287009801 hexamer interface [polypeptide binding]; other site 1168287009802 ligand binding site [chemical binding]; other site 1168287009803 putative active site [active] 1168287009804 NAD(P) binding site [chemical binding]; other site 1168287009805 Nitronate monooxygenase; Region: NMO; pfam03060 1168287009806 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287009807 FMN binding site [chemical binding]; other site 1168287009808 substrate binding site [chemical binding]; other site 1168287009809 putative catalytic residue [active] 1168287009810 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1168287009811 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1168287009812 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1168287009813 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1168287009814 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1168287009815 RNase E interface [polypeptide binding]; other site 1168287009816 trimer interface [polypeptide binding]; other site 1168287009817 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1168287009818 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1168287009819 RNase E interface [polypeptide binding]; other site 1168287009820 trimer interface [polypeptide binding]; other site 1168287009821 active site 1168287009822 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1168287009823 putative nucleic acid binding region [nucleotide binding]; other site 1168287009824 G-X-X-G motif; other site 1168287009825 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1168287009826 RNA binding site [nucleotide binding]; other site 1168287009827 domain interface; other site 1168287009828 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1168287009829 16S/18S rRNA binding site [nucleotide binding]; other site 1168287009830 S13e-L30e interaction site [polypeptide binding]; other site 1168287009831 25S rRNA binding site [nucleotide binding]; other site 1168287009832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287009833 dimerization interface [polypeptide binding]; other site 1168287009834 putative DNA binding site [nucleotide binding]; other site 1168287009835 putative Zn2+ binding site [ion binding]; other site 1168287009836 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1168287009837 putative hydrophobic ligand binding site [chemical binding]; other site 1168287009838 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1168287009839 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1168287009840 active site 1168287009841 Riboflavin kinase; Region: Flavokinase; pfam01687 1168287009842 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1168287009843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287009844 putative DNA binding site [nucleotide binding]; other site 1168287009845 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1168287009846 FeoA domain; Region: FeoA; pfam04023 1168287009847 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287009848 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287009849 active site 1168287009850 lipid-transfer protein; Provisional; Region: PRK08256 1168287009851 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287009852 active site 1168287009853 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1168287009854 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1168287009855 RNA binding site [nucleotide binding]; other site 1168287009856 active site 1168287009857 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1168287009858 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1168287009859 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1168287009860 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1168287009861 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1168287009862 active site 1168287009863 metal binding site [ion binding]; metal-binding site 1168287009864 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1168287009865 active site 1168287009866 metal binding site [ion binding]; metal-binding site 1168287009867 Predicted acyl esterases [General function prediction only]; Region: COG2936 1168287009868 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1168287009869 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1168287009870 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1168287009871 enoyl-CoA hydratase; Provisional; Region: PRK06190 1168287009872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287009873 substrate binding site [chemical binding]; other site 1168287009874 oxyanion hole (OAH) forming residues; other site 1168287009875 trimer interface [polypeptide binding]; other site 1168287009876 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1168287009877 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1168287009878 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1168287009879 DHH family; Region: DHH; pfam01368 1168287009880 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1168287009881 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1168287009882 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1168287009883 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1168287009884 G1 box; other site 1168287009885 putative GEF interaction site [polypeptide binding]; other site 1168287009886 GTP/Mg2+ binding site [chemical binding]; other site 1168287009887 Switch I region; other site 1168287009888 G2 box; other site 1168287009889 G3 box; other site 1168287009890 Switch II region; other site 1168287009891 G4 box; other site 1168287009892 G5 box; other site 1168287009893 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1168287009894 Translation-initiation factor 2; Region: IF-2; pfam11987 1168287009895 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1168287009896 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1168287009897 putative RNA binding cleft [nucleotide binding]; other site 1168287009898 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1168287009899 NusA N-terminal domain; Region: NusA_N; pfam08529 1168287009900 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1168287009901 RNA binding site [nucleotide binding]; other site 1168287009902 homodimer interface [polypeptide binding]; other site 1168287009903 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1168287009904 G-X-X-G motif; other site 1168287009905 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1168287009906 G-X-X-G motif; other site 1168287009907 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1168287009908 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1168287009909 putative oligomer interface [polypeptide binding]; other site 1168287009910 putative RNA binding site [nucleotide binding]; other site 1168287009911 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1168287009912 dinuclear metal binding motif [ion binding]; other site 1168287009913 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1168287009914 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1168287009915 dimer interface [polypeptide binding]; other site 1168287009916 motif 1; other site 1168287009917 active site 1168287009918 motif 2; other site 1168287009919 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1168287009920 putative deacylase active site [active] 1168287009921 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168287009922 active site 1168287009923 motif 3; other site 1168287009924 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1168287009925 anticodon binding site; other site 1168287009926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287009927 putative substrate translocation pore; other site 1168287009928 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1168287009929 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1168287009930 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1168287009931 active site 1168287009932 SAM binding site [chemical binding]; other site 1168287009933 homodimer interface [polypeptide binding]; other site 1168287009934 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1168287009935 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168287009936 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1168287009937 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1168287009938 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1168287009939 Walker A motif; other site 1168287009940 homodimer interface [polypeptide binding]; other site 1168287009941 ATP binding site [chemical binding]; other site 1168287009942 hydroxycobalamin binding site [chemical binding]; other site 1168287009943 Walker B motif; other site 1168287009944 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1168287009945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287009946 Walker A motif; other site 1168287009947 ATP binding site [chemical binding]; other site 1168287009948 Walker B motif; other site 1168287009949 arginine finger; other site 1168287009950 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1168287009951 metal ion-dependent adhesion site (MIDAS); other site 1168287009952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168287009953 Coenzyme A binding pocket [chemical binding]; other site 1168287009954 malate:quinone oxidoreductase; Validated; Region: PRK05257 1168287009955 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1168287009956 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1168287009957 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287009958 mycothione reductase; Reviewed; Region: PRK07846 1168287009959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287009960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287009961 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287009962 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1168287009963 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 1168287009964 nickel binding site [ion binding]; other site 1168287009965 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1168287009966 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1168287009967 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1168287009968 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287009969 PPE family; Region: PPE; pfam00823 1168287009970 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 1168287009971 classical (c) SDRs; Region: SDR_c; cd05233 1168287009972 NAD(P) binding site [chemical binding]; other site 1168287009973 active site 1168287009974 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287009975 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287009976 NAD(P) binding site [chemical binding]; other site 1168287009977 catalytic residues [active] 1168287009978 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1168287009979 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1168287009980 catalytic triad [active] 1168287009981 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1168287009982 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168287009983 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287009984 cobyric acid synthase; Provisional; Region: PRK00784 1168287009985 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1168287009986 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1168287009987 catalytic triad [active] 1168287009988 methionine aminopeptidase; Provisional; Region: PRK12318 1168287009989 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1168287009990 active site 1168287009991 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1168287009992 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1168287009993 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1168287009994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168287009995 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1168287009996 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1168287009997 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1168287009998 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1168287009999 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1168287010000 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1168287010001 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1168287010002 active site 1168287010003 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1168287010004 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1168287010005 putative substrate binding region [chemical binding]; other site 1168287010006 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1168287010007 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1168287010008 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1168287010009 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1168287010010 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1168287010011 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1168287010012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287010013 FeS/SAM binding site; other site 1168287010014 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1168287010015 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1168287010016 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1168287010017 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1168287010018 hinge region; other site 1168287010019 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1168287010020 putative nucleotide binding site [chemical binding]; other site 1168287010021 uridine monophosphate binding site [chemical binding]; other site 1168287010022 homohexameric interface [polypeptide binding]; other site 1168287010023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287010024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287010025 DNA binding site [nucleotide binding] 1168287010026 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287010027 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1168287010028 putative acyl-acceptor binding pocket; other site 1168287010029 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1168287010030 short chain dehydrogenase; Provisional; Region: PRK06701 1168287010031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010032 NAD(P) binding site [chemical binding]; other site 1168287010033 active site 1168287010034 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1168287010035 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1168287010036 Moco binding site; other site 1168287010037 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1168287010038 metal coordination site [ion binding]; other site 1168287010039 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1168287010040 ChaB; Region: ChaB; pfam06150 1168287010041 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1168287010042 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287010043 MarR family; Region: MarR; pfam01047 1168287010044 amidase; Provisional; Region: PRK07869 1168287010045 Amidase; Region: Amidase; pfam01425 1168287010046 elongation factor Ts; Provisional; Region: tsf; PRK09377 1168287010047 UBA/TS-N domain; Region: UBA; pfam00627 1168287010048 Elongation factor TS; Region: EF_TS; pfam00889 1168287010049 Elongation factor TS; Region: EF_TS; pfam00889 1168287010050 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1168287010051 rRNA interaction site [nucleotide binding]; other site 1168287010052 S8 interaction site; other site 1168287010053 putative laminin-1 binding site; other site 1168287010054 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1168287010055 Peptidase family M23; Region: Peptidase_M23; pfam01551 1168287010056 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1168287010057 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168287010058 active site 1168287010059 DNA binding site [nucleotide binding] 1168287010060 Int/Topo IB signature motif; other site 1168287010061 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1168287010062 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1168287010063 putative active site [active] 1168287010064 putative substrate binding site [chemical binding]; other site 1168287010065 putative FMN binding site [chemical binding]; other site 1168287010066 putative catalytic residues [active] 1168287010067 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1168287010068 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1168287010069 FAD binding pocket [chemical binding]; other site 1168287010070 FAD binding motif [chemical binding]; other site 1168287010071 phosphate binding motif [ion binding]; other site 1168287010072 NAD binding pocket [chemical binding]; other site 1168287010073 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287010074 PPE family; Region: PPE; pfam00823 1168287010075 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1168287010076 DNA protecting protein DprA; Region: dprA; TIGR00732 1168287010077 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1168287010078 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1168287010079 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1168287010080 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1168287010081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287010082 Walker A motif; other site 1168287010083 ATP binding site [chemical binding]; other site 1168287010084 Walker B motif; other site 1168287010085 arginine finger; other site 1168287010086 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1168287010087 hypothetical protein; Reviewed; Region: PRK12497 1168287010088 potential frameshift: common BLAST hit: gi|379755600|ref|YP_005344272.1| formate dehydrogenase accessory protein 1168287010089 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1168287010090 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1168287010091 putative molybdopterin cofactor binding site [chemical binding]; other site 1168287010092 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1168287010093 putative molybdopterin cofactor binding site; other site 1168287010094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010095 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287010096 NAD(P) binding site [chemical binding]; other site 1168287010097 active site 1168287010098 ANTAR domain; Region: ANTAR; pfam03861 1168287010099 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1168287010100 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1168287010101 RNA/DNA hybrid binding site [nucleotide binding]; other site 1168287010102 active site 1168287010103 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1168287010104 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1168287010105 Catalytic site [active] 1168287010106 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1168287010107 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1168287010108 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1168287010109 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1168287010110 RimM N-terminal domain; Region: RimM; pfam01782 1168287010111 PRC-barrel domain; Region: PRC; pfam05239 1168287010112 hypothetical protein; Provisional; Region: PRK02821 1168287010113 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1168287010114 G-X-X-G motif; other site 1168287010115 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1168287010116 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1168287010117 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1168287010118 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1168287010119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287010121 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1168287010122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287010123 active site 1168287010124 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287010125 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1168287010126 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287010127 active site 1168287010128 signal recognition particle protein; Provisional; Region: PRK10867 1168287010129 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1168287010130 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1168287010131 P loop; other site 1168287010132 GTP binding site [chemical binding]; other site 1168287010133 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1168287010134 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287010135 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1168287010136 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1168287010137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287010138 ATP binding site [chemical binding]; other site 1168287010139 putative Mg++ binding site [ion binding]; other site 1168287010140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287010141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168287010142 active site 1168287010143 PII uridylyl-transferase; Provisional; Region: PRK03381 1168287010144 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168287010145 metal binding triad; other site 1168287010146 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168287010147 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1168287010148 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1168287010149 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1168287010150 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1168287010151 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1168287010152 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1168287010153 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1168287010154 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1168287010155 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168287010156 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1168287010157 AAA domain; Region: AAA_23; pfam13476 1168287010158 Walker A/P-loop; other site 1168287010159 ATP binding site [chemical binding]; other site 1168287010160 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1168287010161 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1168287010162 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1168287010163 ABC transporter signature motif; other site 1168287010164 Walker B; other site 1168287010165 D-loop; other site 1168287010166 H-loop/switch region; other site 1168287010167 acylphosphatase; Provisional; Region: PRK14422 1168287010168 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1168287010169 potential frameshift: common BLAST hit: gi|379763176|ref|YP_005349573.1| glcNAc-PI de-N-acetylase family protein 1168287010170 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1168287010171 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1168287010172 DNA binding site [nucleotide binding] 1168287010173 catalytic residue [active] 1168287010174 H2TH interface [polypeptide binding]; other site 1168287010175 putative catalytic residues [active] 1168287010176 turnover-facilitating residue; other site 1168287010177 intercalation triad [nucleotide binding]; other site 1168287010178 8OG recognition residue [nucleotide binding]; other site 1168287010179 putative reading head residues; other site 1168287010180 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168287010181 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1168287010182 ribonuclease III; Reviewed; Region: rnc; PRK00102 1168287010183 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1168287010184 dimerization interface [polypeptide binding]; other site 1168287010185 active site 1168287010186 metal binding site [ion binding]; metal-binding site 1168287010187 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1168287010188 dsRNA binding site [nucleotide binding]; other site 1168287010189 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1168287010190 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1168287010191 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1168287010192 Predicted permease; Region: DUF318; pfam03773 1168287010193 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1168287010194 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168287010195 PYR/PP interface [polypeptide binding]; other site 1168287010196 dimer interface [polypeptide binding]; other site 1168287010197 TPP binding site [chemical binding]; other site 1168287010198 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287010199 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1168287010200 TPP-binding site [chemical binding]; other site 1168287010201 dimer interface [polypeptide binding]; other site 1168287010202 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168287010203 MULE transposase domain; Region: MULE; pfam10551 1168287010204 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287010205 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287010206 active site 1168287010207 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1168287010208 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1168287010209 active site 1168287010210 (T/H)XGH motif; other site 1168287010211 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1168287010212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287010213 S-adenosylmethionine binding site [chemical binding]; other site 1168287010214 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1168287010215 putative active site [active] 1168287010216 redox center [active] 1168287010217 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1168287010218 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1168287010219 catalytic residues [active] 1168287010220 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287010221 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287010222 substrate binding pocket [chemical binding]; other site 1168287010223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287010224 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287010225 active site 1168287010226 catalytic tetrad [active] 1168287010227 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1168287010228 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1168287010229 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1168287010230 ssDNA binding site; other site 1168287010231 generic binding surface II; other site 1168287010232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287010233 ATP binding site [chemical binding]; other site 1168287010234 putative Mg++ binding site [ion binding]; other site 1168287010235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287010236 nucleotide binding region [chemical binding]; other site 1168287010237 ATP-binding site [chemical binding]; other site 1168287010238 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1168287010239 DAK2 domain; Region: Dak2; cl03685 1168287010240 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1168287010241 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1168287010242 catalytic residue [active] 1168287010243 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1168287010244 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287010245 classical (c) SDRs; Region: SDR_c; cd05233 1168287010246 NAD(P) binding site [chemical binding]; other site 1168287010247 active site 1168287010248 short chain dehydrogenase; Provisional; Region: PRK06197 1168287010249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010250 NAD(P) binding site [chemical binding]; other site 1168287010251 active site 1168287010252 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1168287010253 short chain dehydrogenase; Provisional; Region: PRK06180 1168287010254 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1168287010255 NADP binding site [chemical binding]; other site 1168287010256 active site 1168287010257 steroid binding site; other site 1168287010258 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168287010259 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1168287010260 putative NAD(P) binding site [chemical binding]; other site 1168287010261 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1168287010262 ligand binding site [chemical binding]; other site 1168287010263 active site 1168287010264 UGI interface [polypeptide binding]; other site 1168287010265 catalytic site [active] 1168287010266 thiamine monophosphate kinase; Provisional; Region: PRK05731 1168287010267 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1168287010268 ATP binding site [chemical binding]; other site 1168287010269 dimerization interface [polypeptide binding]; other site 1168287010270 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1168287010271 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1168287010272 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1168287010273 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1168287010274 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1168287010275 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1168287010276 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1168287010277 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1168287010278 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1168287010279 polyphosphate kinase; Provisional; Region: PRK05443 1168287010280 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1168287010281 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1168287010282 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1168287010283 putative domain interface [polypeptide binding]; other site 1168287010284 putative active site [active] 1168287010285 catalytic site [active] 1168287010286 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1168287010287 putative domain interface [polypeptide binding]; other site 1168287010288 putative active site [active] 1168287010289 catalytic site [active] 1168287010290 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1168287010291 active site 1168287010292 Ap6A binding site [chemical binding]; other site 1168287010293 nudix motif; other site 1168287010294 metal binding site [ion binding]; metal-binding site 1168287010295 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287010296 catalytic core [active] 1168287010297 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1168287010298 IHF dimer interface [polypeptide binding]; other site 1168287010299 IHF - DNA interface [nucleotide binding]; other site 1168287010300 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1168287010301 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1168287010302 substrate binding site [chemical binding]; other site 1168287010303 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1168287010304 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1168287010305 substrate binding site [chemical binding]; other site 1168287010306 ligand binding site [chemical binding]; other site 1168287010307 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1168287010308 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168287010309 Bacterial transcriptional regulator; Region: IclR; pfam01614 1168287010310 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1168287010311 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1168287010312 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168287010313 active site 1168287010314 HIGH motif; other site 1168287010315 nucleotide binding site [chemical binding]; other site 1168287010316 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1168287010317 active site 1168287010318 KMSKS motif; other site 1168287010319 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1168287010320 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1168287010321 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1168287010322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287010323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168287010324 putative substrate translocation pore; other site 1168287010325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287010326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168287010327 putative substrate translocation pore; other site 1168287010328 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1168287010329 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1168287010330 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1168287010331 ligand binding site [chemical binding]; other site 1168287010332 NAD binding site [chemical binding]; other site 1168287010333 dimerization interface [polypeptide binding]; other site 1168287010334 catalytic site [active] 1168287010335 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1168287010336 putative L-serine binding site [chemical binding]; other site 1168287010337 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1168287010338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287010339 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1168287010340 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168287010341 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1168287010342 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1168287010343 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1168287010344 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1168287010345 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1168287010346 putative valine binding site [chemical binding]; other site 1168287010347 dimer interface [polypeptide binding]; other site 1168287010348 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1168287010349 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1168287010350 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168287010351 PYR/PP interface [polypeptide binding]; other site 1168287010352 dimer interface [polypeptide binding]; other site 1168287010353 TPP binding site [chemical binding]; other site 1168287010354 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287010355 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1168287010356 TPP-binding site [chemical binding]; other site 1168287010357 dimer interface [polypeptide binding]; other site 1168287010358 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1168287010359 Predicted membrane protein [Function unknown]; Region: COG2259 1168287010360 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1168287010361 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1168287010362 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1168287010363 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1168287010364 GatB domain; Region: GatB_Yqey; smart00845 1168287010365 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1168287010366 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168287010367 P-loop; other site 1168287010368 Magnesium ion binding site [ion binding]; other site 1168287010369 6-phosphofructokinase; Provisional; Region: PRK03202 1168287010370 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1168287010371 active site 1168287010372 ADP/pyrophosphate binding site [chemical binding]; other site 1168287010373 dimerization interface [polypeptide binding]; other site 1168287010374 allosteric effector site; other site 1168287010375 fructose-1,6-bisphosphate binding site; other site 1168287010376 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1168287010377 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1168287010378 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1168287010379 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1168287010380 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168287010381 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287010382 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1168287010383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287010385 cystathionine gamma-lyase; Validated; Region: PRK07582 1168287010386 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168287010387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287010388 catalytic residue [active] 1168287010389 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1168287010390 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1168287010391 nucleotide binding pocket [chemical binding]; other site 1168287010392 K-X-D-G motif; other site 1168287010393 catalytic site [active] 1168287010394 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1168287010395 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1168287010396 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1168287010397 Dimer interface [polypeptide binding]; other site 1168287010398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1168287010399 putative DNA binding site [nucleotide binding]; other site 1168287010400 putative Zn2+ binding site [ion binding]; other site 1168287010401 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1168287010402 putative hydrophobic ligand binding site [chemical binding]; other site 1168287010403 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1168287010404 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287010405 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1168287010406 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1168287010407 Ligand Binding Site [chemical binding]; other site 1168287010408 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1168287010409 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1168287010410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287010411 catalytic residue [active] 1168287010412 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287010413 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168287010414 putative acyl-acceptor binding pocket; other site 1168287010415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1168287010416 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1168287010417 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1168287010418 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1168287010419 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1168287010420 Ligand binding site [chemical binding]; other site 1168287010421 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1168287010422 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287010423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287010424 S-adenosylmethionine binding site [chemical binding]; other site 1168287010425 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1168287010426 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1168287010427 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1168287010428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287010429 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287010430 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1168287010431 putative hydrophobic ligand binding site [chemical binding]; other site 1168287010432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010433 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1168287010434 NAD(P) binding site [chemical binding]; other site 1168287010435 active site 1168287010436 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287010437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010438 NAD(P) binding site [chemical binding]; other site 1168287010439 active site 1168287010440 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287010441 anti sigma factor interaction site; other site 1168287010442 regulatory phosphorylation site [posttranslational modification]; other site 1168287010443 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1168287010444 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1168287010445 substrate binding pocket [chemical binding]; other site 1168287010446 chain length determination region; other site 1168287010447 substrate-Mg2+ binding site; other site 1168287010448 catalytic residues [active] 1168287010449 aspartate-rich region 1; other site 1168287010450 active site lid residues [active] 1168287010451 aspartate-rich region 2; other site 1168287010452 phytoene desaturase; Region: crtI_fam; TIGR02734 1168287010453 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1168287010454 active site lid residues [active] 1168287010455 substrate binding pocket [chemical binding]; other site 1168287010456 catalytic residues [active] 1168287010457 substrate-Mg2+ binding site; other site 1168287010458 aspartate-rich region 1; other site 1168287010459 aspartate-rich region 2; other site 1168287010460 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1168287010461 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1168287010462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287010463 S-adenosylmethionine binding site [chemical binding]; other site 1168287010464 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1168287010465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287010466 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1168287010467 iron-sulfur cluster [ion binding]; other site 1168287010468 [2Fe-2S] cluster binding site [ion binding]; other site 1168287010469 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1168287010470 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1168287010471 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1168287010472 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1168287010473 MarR family; Region: MarR_2; pfam12802 1168287010474 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1168287010475 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1168287010476 active site 1168287010477 TDP-binding site; other site 1168287010478 acceptor substrate-binding pocket; other site 1168287010479 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1168287010480 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1168287010481 homotetramer interface [polypeptide binding]; other site 1168287010482 FMN binding site [chemical binding]; other site 1168287010483 homodimer contacts [polypeptide binding]; other site 1168287010484 putative active site [active] 1168287010485 putative substrate binding site [chemical binding]; other site 1168287010486 MMPL family; Region: MMPL; pfam03176 1168287010487 TspO/MBR family; Region: TspO_MBR; pfam03073 1168287010488 DNA photolyase; Region: DNA_photolyase; pfam00875 1168287010489 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1168287010490 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1168287010491 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1168287010492 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1168287010493 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1168287010494 trimer interface [polypeptide binding]; other site 1168287010495 active site 1168287010496 substrate binding site [chemical binding]; other site 1168287010497 CoA binding site [chemical binding]; other site 1168287010498 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1168287010499 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1168287010500 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1168287010501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287010502 S-adenosylmethionine binding site [chemical binding]; other site 1168287010503 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287010504 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287010505 substrate binding site [chemical binding]; other site 1168287010506 oxyanion hole (OAH) forming residues; other site 1168287010507 trimer interface [polypeptide binding]; other site 1168287010508 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1168287010509 nudix motif; other site 1168287010510 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1168287010511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287010512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287010513 Walker A/P-loop; other site 1168287010514 Walker A/P-loop; other site 1168287010515 ATP binding site [chemical binding]; other site 1168287010516 ATP binding site [chemical binding]; other site 1168287010517 Q-loop/lid; other site 1168287010518 ABC transporter signature motif; other site 1168287010519 Walker B; other site 1168287010520 D-loop; other site 1168287010521 H-loop/switch region; other site 1168287010522 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1168287010523 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1168287010524 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1168287010525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287010526 motif II; other site 1168287010527 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1168287010528 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1168287010529 D-pathway; other site 1168287010530 Putative ubiquinol binding site [chemical binding]; other site 1168287010531 Low-spin heme (heme b) binding site [chemical binding]; other site 1168287010532 Putative water exit pathway; other site 1168287010533 Binuclear center (heme o3/CuB) [ion binding]; other site 1168287010534 K-pathway; other site 1168287010535 Putative proton exit pathway; other site 1168287010536 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1168287010537 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1168287010538 siderophore binding site; other site 1168287010539 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1168287010540 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1168287010541 putative NAD(P) binding site [chemical binding]; other site 1168287010542 putative substrate binding site [chemical binding]; other site 1168287010543 catalytic Zn binding site [ion binding]; other site 1168287010544 structural Zn binding site [ion binding]; other site 1168287010545 dimer interface [polypeptide binding]; other site 1168287010546 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1168287010547 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1168287010548 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1168287010549 dimer interface [polypeptide binding]; other site 1168287010550 putative radical transfer pathway; other site 1168287010551 diiron center [ion binding]; other site 1168287010552 tyrosyl radical; other site 1168287010553 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1168287010554 putative hydrophobic ligand binding site [chemical binding]; other site 1168287010555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287010557 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168287010558 Ligand Binding Site [chemical binding]; other site 1168287010559 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287010560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287010561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287010563 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1168287010564 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1168287010565 putative dimer interface [polypeptide binding]; other site 1168287010566 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287010567 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1168287010568 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1168287010569 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1168287010570 active site 1168287010571 dimer interface [polypeptide binding]; other site 1168287010572 catalytic residues [active] 1168287010573 effector binding site; other site 1168287010574 R2 peptide binding site; other site 1168287010575 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1168287010576 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1168287010577 catalytic residues [active] 1168287010578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168287010579 Predicted flavoprotein [General function prediction only]; Region: COG0431 1168287010580 DNA polymerase IV; Validated; Region: PRK03352 1168287010581 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1168287010582 active site 1168287010583 DNA binding site [nucleotide binding] 1168287010584 short chain dehydrogenase; Provisional; Region: PRK07832 1168287010585 classical (c) SDRs; Region: SDR_c; cd05233 1168287010586 NAD(P) binding site [chemical binding]; other site 1168287010587 active site 1168287010588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287010590 Cytochrome P450; Region: p450; cl12078 1168287010591 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287010592 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1168287010593 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1168287010594 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1168287010595 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1168287010596 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1168287010597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287010598 DNA-binding site [nucleotide binding]; DNA binding site 1168287010599 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1168287010600 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1168287010601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1168287010602 DNA-binding site [nucleotide binding]; DNA binding site 1168287010603 FCD domain; Region: FCD; pfam07729 1168287010604 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287010605 active site 1168287010606 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287010607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287010608 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287010609 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287010610 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287010611 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287010612 active site 1168287010613 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1168287010614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010615 NAD(P) binding site [chemical binding]; other site 1168287010616 active site 1168287010617 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1168287010618 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1168287010619 active site 1168287010620 DNA binding site [nucleotide binding] 1168287010621 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1168287010622 DNA binding site [nucleotide binding] 1168287010623 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1168287010624 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1168287010625 nucleotide binding site [chemical binding]; other site 1168287010626 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1168287010627 SBD interface [polypeptide binding]; other site 1168287010628 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1168287010629 FMN binding site [chemical binding]; other site 1168287010630 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1168287010631 dimer interface [polypeptide binding]; other site 1168287010632 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287010633 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1168287010634 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287010635 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1168287010636 dimer interface [polypeptide binding]; other site 1168287010637 active site 1168287010638 enoyl-CoA hydratase; Provisional; Region: PRK05864 1168287010639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287010640 substrate binding site [chemical binding]; other site 1168287010641 oxyanion hole (OAH) forming residues; other site 1168287010642 trimer interface [polypeptide binding]; other site 1168287010643 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287010644 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287010645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287010646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287010647 active site 1168287010648 MspA; Region: MspA; pfam09203 1168287010649 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287010650 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287010651 putative active site [active] 1168287010652 putative substrate binding site [chemical binding]; other site 1168287010653 ATP binding site [chemical binding]; other site 1168287010654 short chain dehydrogenase; Provisional; Region: PRK08278 1168287010655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010656 NAD(P) binding site [chemical binding]; other site 1168287010657 active site 1168287010658 Predicted membrane protein [Function unknown]; Region: COG2259 1168287010659 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287010660 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1168287010661 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287010662 Transport protein; Region: actII; TIGR00833 1168287010663 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287010664 classical (c) SDRs; Region: SDR_c; cd05233 1168287010665 NAD(P) binding site [chemical binding]; other site 1168287010666 active site 1168287010667 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287010668 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1168287010669 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1168287010670 substrate binding pocket [chemical binding]; other site 1168287010671 active site 1168287010672 iron coordination sites [ion binding]; other site 1168287010673 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287010674 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287010675 [2Fe-2S] cluster binding site [ion binding]; other site 1168287010676 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1168287010677 alpha subunit interface [polypeptide binding]; other site 1168287010678 active site 1168287010679 substrate binding site [chemical binding]; other site 1168287010680 Fe binding site [ion binding]; other site 1168287010681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287010682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287010683 NAD(P) binding site [chemical binding]; other site 1168287010684 active site 1168287010685 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1168287010686 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1168287010687 FAD binding pocket [chemical binding]; other site 1168287010688 FAD binding motif [chemical binding]; other site 1168287010689 phosphate binding motif [ion binding]; other site 1168287010690 beta-alpha-beta structure motif; other site 1168287010691 NAD(p) ribose binding residues [chemical binding]; other site 1168287010692 NAD binding pocket [chemical binding]; other site 1168287010693 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1168287010694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287010695 catalytic loop [active] 1168287010696 iron binding site [ion binding]; other site 1168287010697 MarR family; Region: MarR_2; pfam12802 1168287010698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287010699 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1168287010700 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1168287010701 active site 1168287010702 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287010703 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287010704 [2Fe-2S] cluster binding site [ion binding]; other site 1168287010705 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1168287010706 alpha subunit interface [polypeptide binding]; other site 1168287010707 active site 1168287010708 substrate binding site [chemical binding]; other site 1168287010709 Fe binding site [ion binding]; other site 1168287010710 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287010711 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1168287010712 NAD binding site [chemical binding]; other site 1168287010713 catalytic residues [active] 1168287010714 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1168287010715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287010716 acyl-activating enzyme (AAE) consensus motif; other site 1168287010717 AMP binding site [chemical binding]; other site 1168287010718 active site 1168287010719 CoA binding site [chemical binding]; other site 1168287010720 Fic/DOC family; Region: Fic; cl00960 1168287010721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287010722 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1168287010723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287010724 phosphoglucomutase; Validated; Region: PRK07564 1168287010725 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1168287010726 active site 1168287010727 substrate binding site [chemical binding]; other site 1168287010728 metal binding site [ion binding]; metal-binding site 1168287010729 camphor resistance protein CrcB; Provisional; Region: PRK14216 1168287010730 camphor resistance protein CrcB; Provisional; Region: PRK14228 1168287010731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1168287010732 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1168287010733 Protein of unknown function, DUF488; Region: DUF488; cl01246 1168287010734 Integrase core domain; Region: rve; pfam00665 1168287010735 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287010736 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287010737 active site 1168287010738 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1168287010739 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287010740 Fe binding site [ion binding]; other site 1168287010741 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1168287010742 hypothetical protein; Validated; Region: PRK00029 1168287010743 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287010744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287010745 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1168287010746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010747 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1168287010748 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287010749 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1168287010750 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1168287010751 putative active site [active] 1168287010752 catalytic site [active] 1168287010753 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1168287010754 putative active site [active] 1168287010755 catalytic site [active] 1168287010756 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1168287010757 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1168287010758 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287010759 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 1168287010760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168287010761 dimerization interface [polypeptide binding]; other site 1168287010762 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287010763 cyclase homology domain; Region: CHD; cd07302 1168287010764 nucleotidyl binding site; other site 1168287010765 metal binding site [ion binding]; metal-binding site 1168287010766 dimer interface [polypeptide binding]; other site 1168287010767 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287010768 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287010769 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1168287010770 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1168287010771 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1168287010772 active site 1168287010773 iron coordination sites [ion binding]; other site 1168287010774 substrate binding pocket [chemical binding]; other site 1168287010775 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287010776 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287010777 [2Fe-2S] cluster binding site [ion binding]; other site 1168287010778 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1168287010779 alpha subunit interface [polypeptide binding]; other site 1168287010780 active site 1168287010781 substrate binding site [chemical binding]; other site 1168287010782 Fe binding site [ion binding]; other site 1168287010783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168287010784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287010785 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1168287010786 putative effector binding pocket; other site 1168287010787 dimerization interface [polypeptide binding]; other site 1168287010788 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287010789 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287010790 phosphopeptide binding site; other site 1168287010791 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287010792 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287010793 phosphopeptide binding site; other site 1168287010794 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1168287010795 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1168287010796 Walker A/P-loop; other site 1168287010797 ATP binding site [chemical binding]; other site 1168287010798 Q-loop/lid; other site 1168287010799 ABC transporter signature motif; other site 1168287010800 Walker B; other site 1168287010801 D-loop; other site 1168287010802 H-loop/switch region; other site 1168287010803 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1168287010804 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287010805 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287010806 active site 1168287010807 ATP binding site [chemical binding]; other site 1168287010808 substrate binding site [chemical binding]; other site 1168287010809 activation loop (A-loop); other site 1168287010810 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1168287010811 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1168287010812 Kelch domain; Region: Kelch; smart00612 1168287010813 Kelch motif; Region: Kelch_1; pfam01344 1168287010814 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1168287010815 Kelch motif; Region: Kelch_1; pfam01344 1168287010816 Kelch domain; Region: Kelch; smart00612 1168287010817 Kelch motif; Region: Kelch_6; pfam13964 1168287010818 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1168287010819 Kelch motif; Region: Kelch_1; pfam01344 1168287010820 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287010821 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1168287010822 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1168287010823 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1168287010824 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1168287010825 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1168287010826 SmpB-tmRNA interface; other site 1168287010827 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1168287010828 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1168287010829 FtsX-like permease family; Region: FtsX; pfam02687 1168287010830 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1168287010831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168287010832 Walker A/P-loop; other site 1168287010833 ATP binding site [chemical binding]; other site 1168287010834 Q-loop/lid; other site 1168287010835 ABC transporter signature motif; other site 1168287010836 Walker B; other site 1168287010837 D-loop; other site 1168287010838 H-loop/switch region; other site 1168287010839 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1168287010840 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1168287010841 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1168287010842 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1168287010843 RF-1 domain; Region: RF-1; pfam00472 1168287010844 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1168287010845 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1168287010846 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1168287010847 heme-binding site [chemical binding]; other site 1168287010848 hypothetical protein; Provisional; Region: PRK07877 1168287010849 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1168287010850 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1168287010851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168287010852 Histidine kinase; Region: HisKA_3; pfam07730 1168287010853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287010854 ATP binding site [chemical binding]; other site 1168287010855 Mg2+ binding site [ion binding]; other site 1168287010856 G-X-G motif; other site 1168287010857 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287010858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287010859 active site 1168287010860 phosphorylation site [posttranslational modification] 1168287010861 intermolecular recognition site; other site 1168287010862 dimerization interface [polypeptide binding]; other site 1168287010863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287010864 DNA binding residues [nucleotide binding] 1168287010865 dimerization interface [polypeptide binding]; other site 1168287010866 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168287010867 Ligand Binding Site [chemical binding]; other site 1168287010868 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1168287010869 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1168287010870 Binuclear center (active site) [active] 1168287010871 K-pathway; other site 1168287010872 Putative proton exit pathway; other site 1168287010873 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1168287010874 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1168287010875 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1168287010876 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287010877 PPE family; Region: PPE; pfam00823 1168287010878 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287010879 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287010880 PPE family; Region: PPE; pfam00823 1168287010881 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287010882 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1168287010883 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168287010884 active site 1168287010885 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287010886 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287010887 active site 1168287010888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287010889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287010890 active site 1168287010891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287010892 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287010893 active site 1168287010894 catalytic tetrad [active] 1168287010895 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1168287010896 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1168287010897 NADP binding site [chemical binding]; other site 1168287010898 dimer interface [polypeptide binding]; other site 1168287010899 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168287010900 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1168287010901 NAD(P) binding site [chemical binding]; other site 1168287010902 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1168287010903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287010904 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1168287010905 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287010906 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287010907 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1168287010908 active site 1168287010909 catalytic residues [active] 1168287010910 metal binding site [ion binding]; metal-binding site 1168287010911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287010913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287010914 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287010915 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287010916 active site 1168287010917 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287010918 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287010919 putative active site [active] 1168287010920 putative substrate binding site [chemical binding]; other site 1168287010921 ATP binding site [chemical binding]; other site 1168287010922 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287010923 YceI-like domain; Region: YceI; pfam04264 1168287010924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1168287010925 active site 1168287010926 phosphorylation site [posttranslational modification] 1168287010927 intermolecular recognition site; other site 1168287010928 dimerization interface [polypeptide binding]; other site 1168287010929 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1168287010930 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1168287010931 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1168287010932 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1168287010933 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1168287010934 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1168287010935 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1168287010936 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1168287010937 putative dimer interface [polypeptide binding]; other site 1168287010938 [2Fe-2S] cluster binding site [ion binding]; other site 1168287010939 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1168287010940 SLBB domain; Region: SLBB; pfam10531 1168287010941 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1168287010942 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1168287010943 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287010944 catalytic loop [active] 1168287010945 iron binding site [ion binding]; other site 1168287010946 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1168287010947 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287010948 molybdopterin cofactor binding site; other site 1168287010949 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1168287010950 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1168287010951 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1168287010952 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1168287010953 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287010954 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287010955 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1168287010956 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1168287010957 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1168287010958 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1168287010959 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168287010960 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1168287010961 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168287010962 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1168287010963 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168287010964 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1168287010965 Protein of unknown function DUF58; Region: DUF58; pfam01882 1168287010966 MoxR-like ATPases [General function prediction only]; Region: COG0714 1168287010967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287010968 Walker A motif; other site 1168287010969 ATP binding site [chemical binding]; other site 1168287010970 Walker B motif; other site 1168287010971 arginine finger; other site 1168287010972 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1168287010973 classical (c) SDRs; Region: SDR_c; cd05233 1168287010974 NAD(P) binding site [chemical binding]; other site 1168287010975 active site 1168287010976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287010977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287010978 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287010979 putative active site [active] 1168287010980 putative substrate binding site [chemical binding]; other site 1168287010981 ATP binding site [chemical binding]; other site 1168287010982 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287010983 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1168287010984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287010985 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287010986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287010987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287010988 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1168287010989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287010990 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1168287010991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287010992 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1168287010993 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1168287010994 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1168287010995 PAS fold; Region: PAS; pfam00989 1168287010996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1168287010997 putative active site [active] 1168287010998 heme pocket [chemical binding]; other site 1168287010999 PAS domain; Region: PAS; smart00091 1168287011000 PAS domain; Region: PAS_9; pfam13426 1168287011001 putative active site [active] 1168287011002 heme pocket [chemical binding]; other site 1168287011003 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287011004 anti sigma factor interaction site; other site 1168287011005 regulatory phosphorylation site [posttranslational modification]; other site 1168287011006 CheB methylesterase; Region: CheB_methylest; pfam01339 1168287011007 hydroperoxidase II; Provisional; Region: katE; PRK11249 1168287011008 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1168287011009 tetramer interface [polypeptide binding]; other site 1168287011010 heme binding pocket [chemical binding]; other site 1168287011011 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1168287011012 domain interactions; other site 1168287011013 transcription termination factor Rho; Provisional; Region: PRK12678 1168287011014 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287011015 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1168287011016 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1168287011017 putative catalytic site [active] 1168287011018 putative metal binding site [ion binding]; other site 1168287011019 putative phosphate binding site [ion binding]; other site 1168287011020 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1168287011021 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1168287011022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287011023 NAD(P) binding site [chemical binding]; other site 1168287011024 active site 1168287011025 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 1168287011026 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1168287011027 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 1168287011028 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1168287011029 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1168287011030 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1168287011031 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1168287011032 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1168287011033 active site 1168287011034 DNA binding site [nucleotide binding] 1168287011035 Int/Topo IB signature motif; other site 1168287011036 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1168287011037 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1168287011038 PYR/PP interface [polypeptide binding]; other site 1168287011039 dimer interface [polypeptide binding]; other site 1168287011040 tetramer interface [polypeptide binding]; other site 1168287011041 TPP binding site [chemical binding]; other site 1168287011042 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287011043 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1168287011044 TPP-binding site [chemical binding]; other site 1168287011045 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1168287011046 Fe-S cluster binding site [ion binding]; other site 1168287011047 active site 1168287011048 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287011049 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1168287011050 PknH-like extracellular domain; Region: PknH_C; pfam14032 1168287011051 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287011052 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287011053 active site 1168287011054 catalytic tetrad [active] 1168287011055 classical (c) SDRs; Region: SDR_c; cd05233 1168287011056 NAD(P) binding site [chemical binding]; other site 1168287011057 active site 1168287011058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1168287011059 PAS fold; Region: PAS_3; pfam08447 1168287011060 putative active site [active] 1168287011061 heme pocket [chemical binding]; other site 1168287011062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1168287011063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1168287011064 metal binding site [ion binding]; metal-binding site 1168287011065 active site 1168287011066 I-site; other site 1168287011067 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1168287011068 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1168287011069 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1168287011070 active site 1168287011071 catalytic site [active] 1168287011072 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1168287011073 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287011074 NAD binding site [chemical binding]; other site 1168287011075 catalytic Zn binding site [ion binding]; other site 1168287011076 structural Zn binding site [ion binding]; other site 1168287011077 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1168287011078 GAF domain; Region: GAF; pfam01590 1168287011079 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287011080 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1168287011081 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1168287011082 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1168287011083 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168287011084 DNA binding residues [nucleotide binding] 1168287011085 putative dimer interface [polypeptide binding]; other site 1168287011086 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1168287011087 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1168287011088 putative dimer interface [polypeptide binding]; other site 1168287011089 PAS fold; Region: PAS_3; pfam08447 1168287011090 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287011091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168287011092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287011093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287011094 active site 1168287011095 phosphorylation site [posttranslational modification] 1168287011096 intermolecular recognition site; other site 1168287011097 dimerization interface [polypeptide binding]; other site 1168287011098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287011099 DNA binding residues [nucleotide binding] 1168287011100 dimerization interface [polypeptide binding]; other site 1168287011101 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1168287011102 yiaA/B two helix domain; Region: YiaAB; cl01759 1168287011103 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1168287011104 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1168287011105 FMN-binding pocket [chemical binding]; other site 1168287011106 flavin binding motif; other site 1168287011107 phosphate binding motif [ion binding]; other site 1168287011108 beta-alpha-beta structure motif; other site 1168287011109 NAD binding pocket [chemical binding]; other site 1168287011110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287011111 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1168287011112 catalytic loop [active] 1168287011113 iron binding site [ion binding]; other site 1168287011114 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287011115 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1168287011116 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1168287011117 acyl-CoA synthetase; Validated; Region: PRK05850 1168287011118 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1168287011119 acyl-activating enzyme (AAE) consensus motif; other site 1168287011120 active site 1168287011121 thioester reductase domain; Region: Thioester-redct; TIGR01746 1168287011122 Male sterility protein; Region: NAD_binding_4; pfam07993 1168287011123 NAD(P) binding site [chemical binding]; other site 1168287011124 active site 1168287011125 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1168287011126 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1168287011127 short chain dehydrogenase; Provisional; Region: PRK06197 1168287011128 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1168287011129 putative NAD(P) binding site [chemical binding]; other site 1168287011130 active site 1168287011131 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287011132 mce related protein; Region: MCE; pfam02470 1168287011133 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287011134 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1168287011135 catalytic residues [active] 1168287011136 dimer interface [polypeptide binding]; other site 1168287011137 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1168287011138 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1168287011139 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287011140 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287011141 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1168287011142 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1168287011143 Flavoprotein; Region: Flavoprotein; pfam02441 1168287011144 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1168287011145 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1168287011146 dimerization interface [polypeptide binding]; other site 1168287011147 DPS ferroxidase diiron center [ion binding]; other site 1168287011148 ion pore; other site 1168287011149 Helix-turn-helix domain; Region: HTH_18; pfam12833 1168287011150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287011151 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1168287011152 FMN binding site [chemical binding]; other site 1168287011153 Nitroreductase family; Region: Nitroreductase; pfam00881 1168287011154 dimer interface [polypeptide binding]; other site 1168287011155 choline dehydrogenase; Validated; Region: PRK02106 1168287011156 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1168287011157 AAA ATPase domain; Region: AAA_16; pfam13191 1168287011158 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287011159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287011160 DNA binding residues [nucleotide binding] 1168287011161 dimerization interface [polypeptide binding]; other site 1168287011162 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1168287011163 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1168287011164 conserved cys residue [active] 1168287011165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287011166 short chain dehydrogenase; Provisional; Region: PRK08219 1168287011167 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1168287011168 NADP binding site [chemical binding]; other site 1168287011169 active site 1168287011170 steroid binding site; other site 1168287011171 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1168287011172 FMN binding site [chemical binding]; other site 1168287011173 dimer interface [polypeptide binding]; other site 1168287011174 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1168287011175 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1168287011176 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1168287011177 conserved cys residue [active] 1168287011178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1168287011179 hypothetical protein; Validated; Region: PRK00068 1168287011180 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1168287011181 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1168287011182 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1168287011183 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1168287011184 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1168287011185 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1168287011186 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1168287011187 ABC1 family; Region: ABC1; pfam03109 1168287011188 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1168287011189 active site 1168287011190 ATP binding site [chemical binding]; other site 1168287011191 potential frameshift: common BLAST hit: gi|183982629|ref|YP_001850920.1| transposase for ISMyma06 1168287011192 Transcription factor WhiB; Region: Whib; pfam02467 1168287011193 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168287011194 Part of AAA domain; Region: AAA_19; pfam13245 1168287011195 Family description; Region: UvrD_C_2; pfam13538 1168287011196 HRDC domain; Region: HRDC; pfam00570 1168287011197 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1168287011198 catalytic residues [active] 1168287011199 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1168287011200 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1168287011201 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1168287011202 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1168287011203 putative NADH binding site [chemical binding]; other site 1168287011204 putative active site [active] 1168287011205 nudix motif; other site 1168287011206 putative metal binding site [ion binding]; other site 1168287011207 Ion channel; Region: Ion_trans_2; pfam07885 1168287011208 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1168287011209 TrkA-N domain; Region: TrkA_N; pfam02254 1168287011210 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168287011211 Part of AAA domain; Region: AAA_19; pfam13245 1168287011212 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1168287011213 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1168287011214 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168287011215 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1168287011216 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287011217 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287011218 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168287011219 catalytic site [active] 1168287011220 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1168287011221 active site 1168287011222 DNA binding site [nucleotide binding] 1168287011223 TIGR02569 family protein; Region: TIGR02569_actnb 1168287011224 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1168287011225 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1168287011226 ATP binding site [chemical binding]; other site 1168287011227 substrate interface [chemical binding]; other site 1168287011228 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1168287011229 active site residue [active] 1168287011230 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1168287011231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011233 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1168287011234 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1168287011235 dinuclear metal binding motif [ion binding]; other site 1168287011236 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1168287011237 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1168287011238 ATP binding site [chemical binding]; other site 1168287011239 Mg++ binding site [ion binding]; other site 1168287011240 motif III; other site 1168287011241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287011242 nucleotide binding region [chemical binding]; other site 1168287011243 ATP-binding site [chemical binding]; other site 1168287011244 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1168287011245 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168287011246 P-loop; other site 1168287011247 Magnesium ion binding site [ion binding]; other site 1168287011248 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168287011249 Magnesium ion binding site [ion binding]; other site 1168287011250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287011251 catalytic core [active] 1168287011252 isochorismate synthase DhbC; Validated; Region: PRK06923 1168287011253 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1168287011254 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168287011255 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1168287011256 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1168287011257 Transcription factor WhiB; Region: Whib; pfam02467 1168287011258 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1168287011259 PAS domain S-box; Region: sensory_box; TIGR00229 1168287011260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1168287011261 Histidine kinase; Region: HisKA_2; pfam07568 1168287011262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287011263 ATP binding site [chemical binding]; other site 1168287011264 Mg2+ binding site [ion binding]; other site 1168287011265 G-X-G motif; other site 1168287011266 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168287011267 carboxyltransferase (CT) interaction site; other site 1168287011268 biotinylation site [posttranslational modification]; other site 1168287011269 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1168287011270 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1168287011271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287011272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287011273 DNA binding residues [nucleotide binding] 1168287011274 short chain dehydrogenase; Provisional; Region: PRK08278 1168287011275 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1168287011276 NAD(P) binding site [chemical binding]; other site 1168287011277 homodimer interface [polypeptide binding]; other site 1168287011278 active site 1168287011279 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1168287011280 putative deacylase active site [active] 1168287011281 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287011282 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168287011283 NAD(P) binding site [chemical binding]; other site 1168287011284 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1168287011285 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287011286 active site 1168287011287 metal binding site [ion binding]; metal-binding site 1168287011288 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1168287011289 short chain dehydrogenase; Provisional; Region: PRK07856 1168287011290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287011291 NAD(P) binding site [chemical binding]; other site 1168287011292 active site 1168287011293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287011294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287011295 classical (c) SDRs; Region: SDR_c; cd05233 1168287011296 NAD(P) binding site [chemical binding]; other site 1168287011297 active site 1168287011298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011299 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287011300 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287011301 active site 1168287011302 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1168287011303 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1168287011304 catalytic residues [active] 1168287011305 catalytic nucleophile [active] 1168287011306 Recombinase; Region: Recombinase; pfam07508 1168287011307 AAA domain; Region: AAA_25; pfam13481 1168287011308 recA bacterial DNA recombination protein; Region: RecA; cl17211 1168287011309 Alphavirus glycoprotein J; Region: Alpha_GJ; pfam03229 1168287011310 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1168287011311 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1168287011312 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1168287011313 hinge; other site 1168287011314 active site 1168287011315 Predicted GTPases [General function prediction only]; Region: COG1162 1168287011316 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1168287011317 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1168287011318 GTP/Mg2+ binding site [chemical binding]; other site 1168287011319 G4 box; other site 1168287011320 G5 box; other site 1168287011321 G1 box; other site 1168287011322 Switch I region; other site 1168287011323 G2 box; other site 1168287011324 G3 box; other site 1168287011325 Switch II region; other site 1168287011326 Predicted transcriptional regulators [Transcription]; Region: COG1733 1168287011327 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1168287011328 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1168287011329 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287011330 dimer interface [polypeptide binding]; other site 1168287011331 active site 1168287011332 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1168287011333 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1168287011334 putative active site [active] 1168287011335 catalytic triad [active] 1168287011336 putative dimer interface [polypeptide binding]; other site 1168287011337 Domain of unknown function DUF302; Region: DUF302; pfam03625 1168287011338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011340 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1168287011341 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1168287011342 putative di-iron ligands [ion binding]; other site 1168287011343 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1168287011344 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1168287011345 FAD binding pocket [chemical binding]; other site 1168287011346 FAD binding motif [chemical binding]; other site 1168287011347 phosphate binding motif [ion binding]; other site 1168287011348 beta-alpha-beta structure motif; other site 1168287011349 NAD binding pocket [chemical binding]; other site 1168287011350 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287011351 catalytic loop [active] 1168287011352 iron binding site [ion binding]; other site 1168287011353 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287011354 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287011355 NnrU protein; Region: NnrU; cl17713 1168287011356 Phospholipid methyltransferase; Region: PEMT; cl17370 1168287011357 HD domain; Region: HD_5; pfam13487 1168287011358 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168287011359 Zn2+ binding site [ion binding]; other site 1168287011360 Mg2+ binding site [ion binding]; other site 1168287011361 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287011362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287011363 DNA binding residues [nucleotide binding] 1168287011364 dimerization interface [polypeptide binding]; other site 1168287011365 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1168287011366 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1168287011367 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1168287011368 30S subunit binding site; other site 1168287011369 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1168287011370 lipoprotein LpqB; Provisional; Region: PRK13616 1168287011371 Sporulation and spore germination; Region: Germane; pfam10646 1168287011372 potential frameshift: common BLAST hit: gi|118464672|ref|YP_883350.1| sensor histidine kinase 1168287011373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287011374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287011375 active site 1168287011376 phosphorylation site [posttranslational modification] 1168287011377 intermolecular recognition site; other site 1168287011378 dimerization interface [polypeptide binding]; other site 1168287011379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287011380 DNA binding site [nucleotide binding] 1168287011381 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1168287011382 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1168287011383 TMP-binding site; other site 1168287011384 ATP-binding site [chemical binding]; other site 1168287011385 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1168287011386 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1168287011387 homotetramer interface [polypeptide binding]; other site 1168287011388 ligand binding site [chemical binding]; other site 1168287011389 catalytic site [active] 1168287011390 NAD binding site [chemical binding]; other site 1168287011391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011393 Rubredoxin [Energy production and conversion]; Region: COG1773 1168287011394 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1168287011395 iron binding site [ion binding]; other site 1168287011396 Rubredoxin [Energy production and conversion]; Region: COG1773 1168287011397 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1168287011398 iron binding site [ion binding]; other site 1168287011399 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1168287011400 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1168287011401 Di-iron ligands [ion binding]; other site 1168287011402 amino acid transporter; Region: 2A0306; TIGR00909 1168287011403 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1168287011404 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1168287011405 hypothetical protein; Provisional; Region: PRK07236 1168287011406 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1168287011407 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1168287011408 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1168287011409 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1168287011410 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1168287011411 active site 1168287011412 substrate binding site [chemical binding]; other site 1168287011413 metal binding site [ion binding]; metal-binding site 1168287011414 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1168287011415 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1168287011416 Transcription factor WhiB; Region: Whib; pfam02467 1168287011417 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1168287011418 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1168287011419 phosphate binding site [ion binding]; other site 1168287011420 dimer interface [polypeptide binding]; other site 1168287011421 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1168287011422 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1168287011423 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1168287011424 FMN binding site [chemical binding]; other site 1168287011425 dimer interface [polypeptide binding]; other site 1168287011426 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1168287011427 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1168287011428 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1168287011429 nudix motif; other site 1168287011430 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1168287011431 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1168287011432 active site 1168287011433 Substrate binding site; other site 1168287011434 Mg++ binding site; other site 1168287011435 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1168287011436 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168287011437 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1168287011438 Probable Catalytic site; other site 1168287011439 metal-binding site 1168287011440 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1168287011441 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1168287011442 NADP binding site [chemical binding]; other site 1168287011443 active site 1168287011444 putative substrate binding site [chemical binding]; other site 1168287011445 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1168287011446 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168287011447 TIGR03089 family protein; Region: TIGR03089 1168287011448 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1168287011449 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168287011450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287011451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1168287011452 active site 1168287011453 motif I; other site 1168287011454 motif II; other site 1168287011455 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1168287011456 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287011457 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287011458 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287011459 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287011460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287011461 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287011462 active site 1168287011463 ATP binding site [chemical binding]; other site 1168287011464 substrate binding site [chemical binding]; other site 1168287011465 activation loop (A-loop); other site 1168287011466 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1168287011467 NHL repeat; Region: NHL; pfam01436 1168287011468 NHL repeat; Region: NHL; pfam01436 1168287011469 NHL repeat; Region: NHL; pfam01436 1168287011470 NHL repeat; Region: NHL; pfam01436 1168287011471 NHL repeat; Region: NHL; pfam01436 1168287011472 PBP superfamily domain; Region: PBP_like_2; cl17296 1168287011473 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 1168287011474 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1168287011475 Walker A/P-loop; other site 1168287011476 ATP binding site [chemical binding]; other site 1168287011477 Q-loop/lid; other site 1168287011478 ABC transporter signature motif; other site 1168287011479 Walker B; other site 1168287011480 D-loop; other site 1168287011481 H-loop/switch region; other site 1168287011482 PBP superfamily domain; Region: PBP_like_2; cl17296 1168287011483 PBP superfamily domain; Region: PBP_like_2; cl17296 1168287011484 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1168287011485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287011486 dimer interface [polypeptide binding]; other site 1168287011487 conserved gate region; other site 1168287011488 putative PBP binding loops; other site 1168287011489 ABC-ATPase subunit interface; other site 1168287011490 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1168287011491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168287011492 dimer interface [polypeptide binding]; other site 1168287011493 conserved gate region; other site 1168287011494 ABC-ATPase subunit interface; other site 1168287011495 Response regulator receiver domain; Region: Response_reg; pfam00072 1168287011496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287011497 active site 1168287011498 phosphorylation site [posttranslational modification] 1168287011499 intermolecular recognition site; other site 1168287011500 dimerization interface [polypeptide binding]; other site 1168287011501 CHASE3 domain; Region: CHASE3; pfam05227 1168287011502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287011503 dimer interface [polypeptide binding]; other site 1168287011504 phosphorylation site [posttranslational modification] 1168287011505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287011506 ATP binding site [chemical binding]; other site 1168287011507 Mg2+ binding site [ion binding]; other site 1168287011508 G-X-G motif; other site 1168287011509 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1168287011510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287011511 active site 1168287011512 phosphorylation site [posttranslational modification] 1168287011513 intermolecular recognition site; other site 1168287011514 dimerization interface [polypeptide binding]; other site 1168287011515 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1168287011516 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287011517 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1168287011518 FAD binding site [chemical binding]; other site 1168287011519 homotetramer interface [polypeptide binding]; other site 1168287011520 substrate binding pocket [chemical binding]; other site 1168287011521 catalytic base [active] 1168287011522 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1168287011523 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1168287011524 ATP-grasp domain; Region: ATP-grasp; pfam02222 1168287011525 Predicted membrane protein [Function unknown]; Region: COG2246 1168287011526 GtrA-like protein; Region: GtrA; pfam04138 1168287011527 Bacterial PH domain; Region: DUF304; pfam03703 1168287011528 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1168287011529 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1168287011530 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1168287011531 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1168287011532 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1168287011533 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168287011534 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168287011535 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168287011536 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1168287011537 active site 1168287011538 dimer interface [polypeptide binding]; other site 1168287011539 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1168287011540 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1168287011541 active site residue [active] 1168287011542 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1168287011543 active site residue [active] 1168287011544 Fe-S metabolism associated domain; Region: SufE; cl00951 1168287011545 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1168287011546 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168287011547 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1168287011548 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168287011549 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168287011550 carboxyltransferase (CT) interaction site; other site 1168287011551 biotinylation site [posttranslational modification]; other site 1168287011552 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287011553 anti sigma factor interaction site; other site 1168287011554 regulatory phosphorylation site [posttranslational modification]; other site 1168287011555 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1168287011556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287011557 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1168287011558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287011559 DNA binding residues [nucleotide binding] 1168287011560 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1168287011561 L-lysine aminotransferase; Provisional; Region: PRK08297 1168287011562 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168287011563 inhibitor-cofactor binding pocket; inhibition site 1168287011564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287011565 catalytic residue [active] 1168287011566 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1168287011567 AsnC family; Region: AsnC_trans_reg; pfam01037 1168287011568 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1168287011569 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287011570 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287011571 NAD(P) binding site [chemical binding]; other site 1168287011572 catalytic residues [active] 1168287011573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168287011576 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1168287011577 ATP binding site [chemical binding]; other site 1168287011578 putative Mg++ binding site [ion binding]; other site 1168287011579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168287011580 nucleotide binding region [chemical binding]; other site 1168287011581 ATP-binding site [chemical binding]; other site 1168287011582 DEAD/H associated; Region: DEAD_assoc; pfam08494 1168287011583 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1168287011584 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1168287011585 putative DNA binding site [nucleotide binding]; other site 1168287011586 catalytic residue [active] 1168287011587 putative H2TH interface [polypeptide binding]; other site 1168287011588 putative catalytic residues [active] 1168287011589 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1168287011590 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1168287011591 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1168287011592 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287011593 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1168287011594 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1168287011595 oligomer interface [polypeptide binding]; other site 1168287011596 metal binding site [ion binding]; metal-binding site 1168287011597 metal binding site [ion binding]; metal-binding site 1168287011598 putative Cl binding site [ion binding]; other site 1168287011599 aspartate ring; other site 1168287011600 basic sphincter; other site 1168287011601 hydrophobic gate; other site 1168287011602 periplasmic entrance; other site 1168287011603 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287011604 PPE family; Region: PPE; pfam00823 1168287011605 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287011606 PPE family; Region: PPE; pfam00823 1168287011607 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1168287011608 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1168287011609 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1168287011610 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1168287011611 active site 1168287011612 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1168287011613 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1168287011614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287011615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287011616 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287011617 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1168287011618 putative active site pocket [active] 1168287011619 dimerization interface [polypeptide binding]; other site 1168287011620 putative catalytic residue [active] 1168287011621 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287011622 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287011623 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1168287011624 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1168287011625 metal binding site [ion binding]; metal-binding site 1168287011626 putative dimer interface [polypeptide binding]; other site 1168287011627 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1168287011628 amidohydrolase; Region: amidohydrolases; TIGR01891 1168287011629 metal binding site [ion binding]; metal-binding site 1168287011630 Cutinase; Region: Cutinase; pfam01083 1168287011631 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1168287011632 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1168287011633 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1168287011634 active site 1168287011635 substrate binding site [chemical binding]; other site 1168287011636 metal binding site [ion binding]; metal-binding site 1168287011637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168287011638 active site 1168287011639 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1168287011640 hypothetical protein; Provisional; Region: PRK13685 1168287011641 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1168287011642 metal ion-dependent adhesion site (MIDAS); other site 1168287011643 hypothetical protein; Provisional; Region: PRK13685 1168287011644 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1168287011645 metal ion-dependent adhesion site (MIDAS); other site 1168287011646 Cupin domain; Region: Cupin_2; cl17218 1168287011647 Cupin domain; Region: Cupin_2; pfam07883 1168287011648 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1168287011649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287011650 DNA-binding site [nucleotide binding]; DNA binding site 1168287011651 FCD domain; Region: FCD; pfam07729 1168287011652 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1168287011653 adenosine deaminase; Provisional; Region: PRK09358 1168287011654 active site 1168287011655 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1168287011656 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1168287011657 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1168287011658 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1168287011659 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1168287011660 active site 1168287011661 catalytic motif [active] 1168287011662 Zn binding site [ion binding]; other site 1168287011663 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1168287011664 putative Iron-sulfur protein interface [polypeptide binding]; other site 1168287011665 putative proximal heme binding site [chemical binding]; other site 1168287011666 putative SdhD-like interface [polypeptide binding]; other site 1168287011667 putative distal heme binding site [chemical binding]; other site 1168287011668 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1168287011669 putative Iron-sulfur protein interface [polypeptide binding]; other site 1168287011670 putative proximal heme binding site [chemical binding]; other site 1168287011671 putative SdhC-like subunit interface [polypeptide binding]; other site 1168287011672 putative distal heme binding site [chemical binding]; other site 1168287011673 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1168287011674 L-aspartate oxidase; Provisional; Region: PRK06175 1168287011675 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1168287011676 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1168287011677 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1168287011678 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287011679 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1168287011680 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1168287011681 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1168287011682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287011683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287011684 DNA binding residues [nucleotide binding] 1168287011685 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287011686 hypothetical protein; Provisional; Region: PRK06541 1168287011687 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168287011688 inhibitor-cofactor binding pocket; inhibition site 1168287011689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287011690 catalytic residue [active] 1168287011691 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1168287011692 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1168287011693 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1168287011694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287011695 putative substrate translocation pore; other site 1168287011696 Amidohydrolase; Region: Amidohydro_4; pfam13147 1168287011697 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287011698 active site 1168287011699 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1168287011700 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1168287011701 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1168287011702 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1168287011703 active site 1168287011704 HIGH motif; other site 1168287011705 dimer interface [polypeptide binding]; other site 1168287011706 KMSKS motif; other site 1168287011707 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287011708 isocitrate dehydrogenase; Validated; Region: PRK08299 1168287011709 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1168287011710 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1168287011711 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1168287011712 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168287011713 homodimer interface [polypeptide binding]; other site 1168287011714 substrate-cofactor binding pocket; other site 1168287011715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287011716 catalytic residue [active] 1168287011717 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1168287011718 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1168287011719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287011720 S-adenosylmethionine binding site [chemical binding]; other site 1168287011721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287011722 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1168287011723 Alphavirus glycoprotein J; Region: Alpha_GJ; pfam03229 1168287011724 AAA domain; Region: AAA_25; pfam13481 1168287011725 recA bacterial DNA recombination protein; Region: RecA; cl17211 1168287011726 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1168287011727 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1168287011728 catalytic residues [active] 1168287011729 catalytic nucleophile [active] 1168287011730 Recombinase; Region: Recombinase; pfam07508 1168287011731 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287011732 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287011733 active site 1168287011734 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287011735 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1168287011736 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1168287011737 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1168287011738 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1168287011739 homodimer interface [polypeptide binding]; other site 1168287011740 NADP binding site [chemical binding]; other site 1168287011741 substrate binding site [chemical binding]; other site 1168287011742 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1168287011743 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1168287011744 active site 1168287011745 FMN binding site [chemical binding]; other site 1168287011746 substrate binding site [chemical binding]; other site 1168287011747 putative catalytic residue [active] 1168287011748 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287011749 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287011750 phosphopeptide binding site; other site 1168287011751 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287011752 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287011753 phosphopeptide binding site; other site 1168287011754 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168287011755 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1168287011756 Walker A/P-loop; other site 1168287011757 ATP binding site [chemical binding]; other site 1168287011758 Q-loop/lid; other site 1168287011759 ABC transporter signature motif; other site 1168287011760 Walker B; other site 1168287011761 D-loop; other site 1168287011762 H-loop/switch region; other site 1168287011763 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1168287011764 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1168287011765 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287011766 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287011767 phosphopeptide binding site; other site 1168287011768 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168287011769 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168287011770 phosphopeptide binding site; other site 1168287011771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168287011772 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1168287011773 Walker A/P-loop; other site 1168287011774 ATP binding site [chemical binding]; other site 1168287011775 Q-loop/lid; other site 1168287011776 ABC transporter signature motif; other site 1168287011777 Walker B; other site 1168287011778 D-loop; other site 1168287011779 H-loop/switch region; other site 1168287011780 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168287011781 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1168287011782 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1168287011783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1168287011784 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1168287011785 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1168287011786 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1168287011787 G1 box; other site 1168287011788 GTP/Mg2+ binding site [chemical binding]; other site 1168287011789 G2 box; other site 1168287011790 Switch I region; other site 1168287011791 G3 box; other site 1168287011792 Switch II region; other site 1168287011793 G4 box; other site 1168287011794 G5 box; other site 1168287011795 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1168287011796 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1168287011797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287011798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287011799 ATP binding site [chemical binding]; other site 1168287011800 Mg2+ binding site [ion binding]; other site 1168287011801 G-X-G motif; other site 1168287011802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287011803 S-adenosylmethionine binding site [chemical binding]; other site 1168287011804 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1168287011805 YCII-related domain; Region: YCII; cl00999 1168287011806 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1168287011807 FMN binding site [chemical binding]; other site 1168287011808 dimer interface [polypeptide binding]; other site 1168287011809 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1168287011810 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1168287011811 active site 1168287011812 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1168287011813 generic binding surface II; other site 1168287011814 generic binding surface I; other site 1168287011815 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1168287011816 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1168287011817 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287011818 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1168287011819 dimer interaction site [polypeptide binding]; other site 1168287011820 substrate-binding tunnel; other site 1168287011821 active site 1168287011822 catalytic site [active] 1168287011823 substrate binding site [chemical binding]; other site 1168287011824 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287011825 catalytic core [active] 1168287011826 short chain dehydrogenase; Provisional; Region: PRK07201 1168287011827 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1168287011828 putative NAD(P) binding site [chemical binding]; other site 1168287011829 active site 1168287011830 putative substrate binding site [chemical binding]; other site 1168287011831 classical (c) SDRs; Region: SDR_c; cd05233 1168287011832 NAD(P) binding site [chemical binding]; other site 1168287011833 active site 1168287011834 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287011835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287011836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287011837 S-adenosylmethionine binding site [chemical binding]; other site 1168287011838 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1168287011839 active site 1168287011840 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1168287011841 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1168287011842 dimer interface [polypeptide binding]; other site 1168287011843 active site 1168287011844 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1168287011845 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1168287011846 PYR/PP interface [polypeptide binding]; other site 1168287011847 dimer interface [polypeptide binding]; other site 1168287011848 tetramer interface [polypeptide binding]; other site 1168287011849 TPP binding site [chemical binding]; other site 1168287011850 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287011851 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1168287011852 TPP-binding site [chemical binding]; other site 1168287011853 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168287011854 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287011855 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1168287011856 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1168287011857 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1168287011858 putative active site [active] 1168287011859 putative substrate binding site [chemical binding]; other site 1168287011860 putative FMN binding site [chemical binding]; other site 1168287011861 putative catalytic residues [active] 1168287011862 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1168287011863 DNA Polymerase Y-family; Region: PolY_like; cd03468 1168287011864 DNA binding site [nucleotide binding] 1168287011865 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287011866 Cytochrome P450; Region: p450; cl12078 1168287011867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011869 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287011870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287011871 NAD(P) binding site [chemical binding]; other site 1168287011872 active site 1168287011873 classical (c) SDRs; Region: SDR_c; cd05233 1168287011874 NAD(P) binding site [chemical binding]; other site 1168287011875 active site 1168287011876 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287011877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011879 GMP synthase; Reviewed; Region: guaA; PRK00074 1168287011880 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1168287011881 AMP/PPi binding site [chemical binding]; other site 1168287011882 candidate oxyanion hole; other site 1168287011883 catalytic triad [active] 1168287011884 potential glutamine specificity residues [chemical binding]; other site 1168287011885 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1168287011886 ATP Binding subdomain [chemical binding]; other site 1168287011887 Ligand Binding sites [chemical binding]; other site 1168287011888 Dimerization subdomain; other site 1168287011889 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287011890 PPE family; Region: PPE; pfam00823 1168287011891 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287011892 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1168287011893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287011894 motif II; other site 1168287011895 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1168287011896 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1168287011897 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1168287011898 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1168287011899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011901 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1168287011902 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1168287011903 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1168287011904 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1168287011905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168287011906 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1168287011907 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1168287011908 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168287011909 phosphate binding site [ion binding]; other site 1168287011910 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1168287011911 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168287011912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1168287011913 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1168287011914 active site 1168287011915 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1168287011916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287011917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1168287011918 DNA binding residues [nucleotide binding] 1168287011919 Transcription factor WhiB; Region: Whib; pfam02467 1168287011920 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1168287011921 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1168287011922 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1168287011923 [2Fe-2S] cluster binding site [ion binding]; other site 1168287011924 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287011925 Fe binding site [ion binding]; other site 1168287011926 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1168287011927 E-class dimer interface [polypeptide binding]; other site 1168287011928 P-class dimer interface [polypeptide binding]; other site 1168287011929 active site 1168287011930 Cu2+ binding site [ion binding]; other site 1168287011931 Zn2+ binding site [ion binding]; other site 1168287011932 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1168287011933 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1168287011934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287011935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287011936 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1168287011937 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1168287011938 ring oligomerisation interface [polypeptide binding]; other site 1168287011939 ATP/Mg binding site [chemical binding]; other site 1168287011940 stacking interactions; other site 1168287011941 hinge regions; other site 1168287011942 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1168287011943 oligomerisation interface [polypeptide binding]; other site 1168287011944 mobile loop; other site 1168287011945 roof hairpin; other site 1168287011946 UGMP family protein; Validated; Region: PRK09604 1168287011947 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1168287011948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287011949 Coenzyme A binding pocket [chemical binding]; other site 1168287011950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168287011951 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1168287011952 Glycoprotease family; Region: Peptidase_M22; pfam00814 1168287011953 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1168287011954 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287011955 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287011956 alanine racemase; Reviewed; Region: alr; PRK00053 1168287011957 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1168287011958 active site 1168287011959 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168287011960 dimer interface [polypeptide binding]; other site 1168287011961 substrate binding site [chemical binding]; other site 1168287011962 catalytic residues [active] 1168287011963 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1168287011964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287011965 catalytic residue [active] 1168287011966 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1168287011967 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1168287011968 putative substrate binding site [chemical binding]; other site 1168287011969 putative ATP binding site [chemical binding]; other site 1168287011970 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1168287011971 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1168287011972 glutaminase active site [active] 1168287011973 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1168287011974 dimer interface [polypeptide binding]; other site 1168287011975 active site 1168287011976 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1168287011977 dimer interface [polypeptide binding]; other site 1168287011978 active site 1168287011979 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287011980 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1168287011981 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287011982 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1168287011983 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1168287011984 active site 1168287011985 substrate binding site [chemical binding]; other site 1168287011986 metal binding site [ion binding]; metal-binding site 1168287011987 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1168287011988 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1168287011989 23S rRNA interface [nucleotide binding]; other site 1168287011990 L3 interface [polypeptide binding]; other site 1168287011991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1168287011992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1168287011993 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1168287011994 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1168287011995 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287011996 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1168287011997 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287011998 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287011999 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1168287012000 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1168287012001 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1168287012002 active site 1168287012003 catalytic residues [active] 1168287012004 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1168287012005 Cutinase; Region: Cutinase; pfam01083 1168287012006 Cutinase; Region: Cutinase; pfam01083 1168287012007 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1168287012008 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1168287012009 active site 1168287012010 dimerization interface 3.5A [polypeptide binding]; other site 1168287012011 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1168287012012 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1168287012013 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1168287012014 alphaNTD homodimer interface [polypeptide binding]; other site 1168287012015 alphaNTD - beta interaction site [polypeptide binding]; other site 1168287012016 alphaNTD - beta' interaction site [polypeptide binding]; other site 1168287012017 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1168287012018 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1168287012019 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1168287012020 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168287012021 RNA binding surface [nucleotide binding]; other site 1168287012022 30S ribosomal protein S11; Validated; Region: PRK05309 1168287012023 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1168287012024 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1168287012025 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1168287012026 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1168287012027 rRNA binding site [nucleotide binding]; other site 1168287012028 predicted 30S ribosome binding site; other site 1168287012029 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1168287012030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287012031 active site 1168287012032 phosphorylation site [posttranslational modification] 1168287012033 intermolecular recognition site; other site 1168287012034 dimerization interface [polypeptide binding]; other site 1168287012035 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1168287012036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287012037 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168287012038 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168287012039 ligand binding site [chemical binding]; other site 1168287012040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168287012041 flexible hinge region; other site 1168287012042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287012043 ATP binding site [chemical binding]; other site 1168287012044 Mg2+ binding site [ion binding]; other site 1168287012045 G-X-G motif; other site 1168287012046 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1168287012047 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1168287012048 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1168287012049 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1168287012050 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1168287012051 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1168287012052 NAD binding site [chemical binding]; other site 1168287012053 substrate binding site [chemical binding]; other site 1168287012054 homodimer interface [polypeptide binding]; other site 1168287012055 active site 1168287012056 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1168287012057 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287012058 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287012059 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287012060 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287012061 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1168287012062 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1168287012063 active site 1168287012064 metal binding site [ion binding]; metal-binding site 1168287012065 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1168287012066 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1168287012067 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1168287012068 iron-sulfur cluster [ion binding]; other site 1168287012069 [2Fe-2S] cluster binding site [ion binding]; other site 1168287012070 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1168287012071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287012072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287012073 DNA binding residues [nucleotide binding] 1168287012074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287012075 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1168287012076 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1168287012077 tetrameric interface [polypeptide binding]; other site 1168287012078 NAD binding site [chemical binding]; other site 1168287012079 catalytic residues [active] 1168287012080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287012081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287012082 active site 1168287012083 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168287012084 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1168287012085 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287012086 MarR family; Region: MarR; pfam01047 1168287012087 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1168287012088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287012089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287012090 homodimer interface [polypeptide binding]; other site 1168287012091 catalytic residue [active] 1168287012092 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 1168287012093 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1168287012094 active site 1168287012095 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776 1168287012096 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1168287012097 PYR/PP interface [polypeptide binding]; other site 1168287012098 dimer interface [polypeptide binding]; other site 1168287012099 TPP binding site [chemical binding]; other site 1168287012100 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1168287012101 TPP-binding site [chemical binding]; other site 1168287012102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168287012103 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168287012104 Walker A/P-loop; other site 1168287012105 ATP binding site [chemical binding]; other site 1168287012106 Q-loop/lid; other site 1168287012107 ABC transporter signature motif; other site 1168287012108 Walker B; other site 1168287012109 D-loop; other site 1168287012110 H-loop/switch region; other site 1168287012111 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168287012112 FtsX-like permease family; Region: FtsX; pfam02687 1168287012113 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1168287012114 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1168287012115 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1168287012116 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287012117 Putative zinc-finger; Region: zf-HC2; pfam13490 1168287012118 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1168287012119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287012120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287012121 DNA binding residues [nucleotide binding] 1168287012122 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1168287012123 active site 1168287012124 adenylate kinase; Reviewed; Region: adk; PRK00279 1168287012125 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1168287012126 AMP-binding site [chemical binding]; other site 1168287012127 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1168287012128 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1168287012129 SecY translocase; Region: SecY; pfam00344 1168287012130 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287012131 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287012132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168287012133 Coenzyme A binding pocket [chemical binding]; other site 1168287012134 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1168287012135 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287012136 nucleotide binding site [chemical binding]; other site 1168287012137 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1168287012138 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1168287012139 NAD binding site [chemical binding]; other site 1168287012140 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1168287012141 intersubunit interface [polypeptide binding]; other site 1168287012142 active site 1168287012143 Zn2+ binding site [ion binding]; other site 1168287012144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287012145 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168287012146 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287012147 NAD(P) binding site [chemical binding]; other site 1168287012148 classical (c) SDRs; Region: SDR_c; cd05233 1168287012149 NAD(P) binding site [chemical binding]; other site 1168287012150 active site 1168287012151 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287012152 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287012153 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287012154 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287012155 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287012156 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287012157 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1168287012158 tandem repeat interface [polypeptide binding]; other site 1168287012159 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1168287012160 oligomer interface [polypeptide binding]; other site 1168287012161 active site residues [active] 1168287012162 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1168287012163 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1168287012164 tandem repeat interface [polypeptide binding]; other site 1168287012165 oligomer interface [polypeptide binding]; other site 1168287012166 active site residues [active] 1168287012167 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287012168 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287012169 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1168287012170 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1168287012171 23S rRNA binding site [nucleotide binding]; other site 1168287012172 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1168287012173 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1168287012174 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1168287012175 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1168287012176 5S rRNA interface [nucleotide binding]; other site 1168287012177 L27 interface [polypeptide binding]; other site 1168287012178 23S rRNA interface [nucleotide binding]; other site 1168287012179 L5 interface [polypeptide binding]; other site 1168287012180 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1168287012181 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1168287012182 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1168287012183 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1168287012184 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1168287012185 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1168287012186 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1168287012187 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1168287012188 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1168287012189 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1168287012190 RNA binding site [nucleotide binding]; other site 1168287012191 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1168287012192 Cation efflux family; Region: Cation_efflux; cl00316 1168287012193 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1168287012194 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287012195 PPE family; Region: PPE; pfam00823 1168287012196 PE family; Region: PE; pfam00934 1168287012197 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1168287012198 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168287012199 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168287012200 dimer interface [polypeptide binding]; other site 1168287012201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287012202 catalytic residue [active] 1168287012203 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1168287012204 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1168287012205 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1168287012206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168287012207 catalytic residue [active] 1168287012208 PE family; Region: PE; pfam00934 1168287012209 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287012210 PPE family; Region: PPE; pfam00823 1168287012211 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287012212 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1168287012213 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1168287012214 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1168287012215 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1168287012216 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1168287012217 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287012218 PPE family; Region: PPE; pfam00823 1168287012219 PE family; Region: PE; pfam00934 1168287012220 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287012221 PPE family; Region: PPE; pfam00823 1168287012222 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287012223 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1168287012224 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168287012225 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287012226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287012227 motif II; other site 1168287012228 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1168287012229 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1168287012230 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1168287012231 MgtE intracellular N domain; Region: MgtE_N; smart00924 1168287012232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1168287012233 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1168287012234 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1168287012235 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1168287012236 heme bH binding site [chemical binding]; other site 1168287012237 intrachain domain interface; other site 1168287012238 heme bL binding site [chemical binding]; other site 1168287012239 interchain domain interface [polypeptide binding]; other site 1168287012240 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1168287012241 Qo binding site; other site 1168287012242 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1168287012243 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1168287012244 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1168287012245 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287012246 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1168287012247 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1168287012248 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1168287012249 catalytic residues [active] 1168287012250 Recombinase; Region: Recombinase; pfam07508 1168287012251 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287012252 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287012253 active site 1168287012254 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1168287012255 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1168287012256 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1168287012257 Sulfatase; Region: Sulfatase; pfam00884 1168287012258 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1168287012259 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1168287012260 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1168287012261 putative translocon interaction site; other site 1168287012262 signal recognition particle (SRP54) interaction site; other site 1168287012263 L23 interface [polypeptide binding]; other site 1168287012264 trigger factor interaction site; other site 1168287012265 23S rRNA interface [nucleotide binding]; other site 1168287012266 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1168287012267 23S rRNA interface [nucleotide binding]; other site 1168287012268 5S rRNA interface [nucleotide binding]; other site 1168287012269 putative antibiotic binding site [chemical binding]; other site 1168287012270 L25 interface [polypeptide binding]; other site 1168287012271 L27 interface [polypeptide binding]; other site 1168287012272 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1168287012273 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1168287012274 G-X-X-G motif; other site 1168287012275 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1168287012276 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1168287012277 putative translocon binding site; other site 1168287012278 protein-rRNA interface [nucleotide binding]; other site 1168287012279 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1168287012280 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1168287012281 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1168287012282 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1168287012283 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1168287012284 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1168287012285 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1168287012286 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1168287012287 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287012288 Cytochrome P450; Region: p450; cl12078 1168287012289 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1168287012290 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1168287012291 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1168287012292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168287012293 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1168287012294 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1168287012295 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168287012296 phosphate binding site [ion binding]; other site 1168287012297 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1168287012298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168287012299 FeS/SAM binding site; other site 1168287012300 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1168287012301 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1168287012302 mycofactocin precursor; Region: mycofactocin; TIGR03969 1168287012303 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287012304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012305 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1168287012306 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287012307 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287012308 active site 1168287012309 catalytic tetrad [active] 1168287012310 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1168287012311 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1168287012312 active site 1168287012313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1168287012314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287012315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287012316 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287012317 classical (c) SDRs; Region: SDR_c; cd05233 1168287012318 NAD(P) binding site [chemical binding]; other site 1168287012319 active site 1168287012320 Short C-terminal domain; Region: SHOCT; pfam09851 1168287012321 PE family; Region: PE; pfam00934 1168287012322 elongation factor Tu; Reviewed; Region: PRK00049 1168287012323 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1168287012324 G1 box; other site 1168287012325 GEF interaction site [polypeptide binding]; other site 1168287012326 GTP/Mg2+ binding site [chemical binding]; other site 1168287012327 Switch I region; other site 1168287012328 G2 box; other site 1168287012329 G3 box; other site 1168287012330 Switch II region; other site 1168287012331 G4 box; other site 1168287012332 G5 box; other site 1168287012333 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1168287012334 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1168287012335 Antibiotic Binding Site [chemical binding]; other site 1168287012336 elongation factor G; Reviewed; Region: PRK00007 1168287012337 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1168287012338 G1 box; other site 1168287012339 putative GEF interaction site [polypeptide binding]; other site 1168287012340 GTP/Mg2+ binding site [chemical binding]; other site 1168287012341 Switch I region; other site 1168287012342 G2 box; other site 1168287012343 G3 box; other site 1168287012344 Switch II region; other site 1168287012345 G4 box; other site 1168287012346 G5 box; other site 1168287012347 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1168287012348 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1168287012349 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1168287012350 30S ribosomal protein S7; Validated; Region: PRK05302 1168287012351 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1168287012352 S17 interaction site [polypeptide binding]; other site 1168287012353 S8 interaction site; other site 1168287012354 16S rRNA interaction site [nucleotide binding]; other site 1168287012355 streptomycin interaction site [chemical binding]; other site 1168287012356 23S rRNA interaction site [nucleotide binding]; other site 1168287012357 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1168287012358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287012359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012360 WHG domain; Region: WHG; pfam13305 1168287012361 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1168287012362 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1168287012363 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287012364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287012365 substrate binding site [chemical binding]; other site 1168287012366 oxyanion hole (OAH) forming residues; other site 1168287012367 trimer interface [polypeptide binding]; other site 1168287012368 PaaX-like protein; Region: PaaX; pfam07848 1168287012369 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1168287012370 enoyl-CoA hydratase; Provisional; Region: PRK12478 1168287012371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287012372 substrate binding site [chemical binding]; other site 1168287012373 oxyanion hole (OAH) forming residues; other site 1168287012374 trimer interface [polypeptide binding]; other site 1168287012375 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1168287012376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287012377 active site 1168287012378 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1168287012379 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287012380 endonuclease IV; Provisional; Region: PRK01060 1168287012381 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1168287012382 AP (apurinic/apyrimidinic) site pocket; other site 1168287012383 DNA interaction; other site 1168287012384 Metal-binding active site; metal-binding site 1168287012385 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1168287012386 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1168287012387 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1168287012388 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1168287012389 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1168287012390 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1168287012391 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1168287012392 G-loop; other site 1168287012393 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1168287012394 DNA binding site [nucleotide binding] 1168287012395 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1168287012396 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1168287012397 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1168287012398 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1168287012399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1168287012400 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1168287012401 RPB10 interaction site [polypeptide binding]; other site 1168287012402 RPB1 interaction site [polypeptide binding]; other site 1168287012403 RPB11 interaction site [polypeptide binding]; other site 1168287012404 RPB3 interaction site [polypeptide binding]; other site 1168287012405 RPB12 interaction site [polypeptide binding]; other site 1168287012406 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1168287012407 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1168287012408 Walker A/P-loop; other site 1168287012409 ATP binding site [chemical binding]; other site 1168287012410 Q-loop/lid; other site 1168287012411 ABC transporter signature motif; other site 1168287012412 Walker B; other site 1168287012413 D-loop; other site 1168287012414 H-loop/switch region; other site 1168287012415 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1168287012416 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1168287012417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287012418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012419 WHG domain; Region: WHG; pfam13305 1168287012420 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1168287012421 core dimer interface [polypeptide binding]; other site 1168287012422 peripheral dimer interface [polypeptide binding]; other site 1168287012423 L10 interface [polypeptide binding]; other site 1168287012424 L11 interface [polypeptide binding]; other site 1168287012425 putative EF-Tu interaction site [polypeptide binding]; other site 1168287012426 putative EF-G interaction site [polypeptide binding]; other site 1168287012427 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1168287012428 23S rRNA interface [nucleotide binding]; other site 1168287012429 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1168287012430 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1168287012431 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168287012432 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287012433 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1168287012434 active site 1168287012435 catalytic site [active] 1168287012436 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1168287012437 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1168287012438 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1168287012439 DinB superfamily; Region: DinB_2; pfam12867 1168287012440 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1168287012441 DinB superfamily; Region: DinB_2; pfam12867 1168287012442 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1168287012443 ABC1 family; Region: ABC1; pfam03109 1168287012444 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1168287012445 active site 1168287012446 ATP binding site [chemical binding]; other site 1168287012447 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287012448 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1168287012449 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287012450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012451 S-adenosylmethionine binding site [chemical binding]; other site 1168287012452 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287012453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012454 S-adenosylmethionine binding site [chemical binding]; other site 1168287012455 YCII-related domain; Region: YCII; cl00999 1168287012456 YCII-related domain; Region: YCII; cl00999 1168287012457 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1168287012458 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287012459 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1168287012460 DNA binding residues [nucleotide binding] 1168287012461 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1168287012462 mRNA/rRNA interface [nucleotide binding]; other site 1168287012463 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1168287012464 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1168287012465 23S rRNA interface [nucleotide binding]; other site 1168287012466 L7/L12 interface [polypeptide binding]; other site 1168287012467 putative thiostrepton binding site; other site 1168287012468 L25 interface [polypeptide binding]; other site 1168287012469 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1168287012470 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1168287012471 putative homodimer interface [polypeptide binding]; other site 1168287012472 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1168287012473 heterodimer interface [polypeptide binding]; other site 1168287012474 homodimer interface [polypeptide binding]; other site 1168287012475 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1168287012476 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1168287012477 active site 1168287012478 catalytic site [active] 1168287012479 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1168287012480 active site 1168287012481 catalytic site [active] 1168287012482 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1168287012483 active site 1168287012484 catalytic site [active] 1168287012485 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1168287012486 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1168287012487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1168287012488 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287012489 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287012490 substrate binding site [chemical binding]; other site 1168287012491 oxyanion hole (OAH) forming residues; other site 1168287012492 trimer interface [polypeptide binding]; other site 1168287012493 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1168287012494 [4Fe-4S] binding site [ion binding]; other site 1168287012495 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1168287012496 molybdopterin cofactor binding site; other site 1168287012497 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1168287012498 molybdopterin cofactor binding site; other site 1168287012499 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1168287012500 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1168287012501 active site 1168287012502 nucleophile elbow; other site 1168287012503 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1168287012504 cyanate hydratase; Validated; Region: PRK02866 1168287012505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1168287012506 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1168287012507 oligomer interface [polypeptide binding]; other site 1168287012508 active site 1168287012509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012510 S-adenosylmethionine binding site [chemical binding]; other site 1168287012511 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1168287012512 putative FMN binding site [chemical binding]; other site 1168287012513 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287012514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012515 S-adenosylmethionine binding site [chemical binding]; other site 1168287012516 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1168287012517 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1168287012518 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1168287012519 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1168287012520 Part of AAA domain; Region: AAA_19; pfam13245 1168287012521 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1168287012522 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1168287012523 AAA domain; Region: AAA_30; pfam13604 1168287012524 Family description; Region: UvrD_C_2; pfam13538 1168287012525 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1168287012526 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1168287012527 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287012528 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287012529 active site 1168287012530 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287012531 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287012532 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1168287012533 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1168287012534 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1168287012535 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1168287012536 PAS fold; Region: PAS_3; pfam08447 1168287012537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1168287012538 putative active site [active] 1168287012539 heme pocket [chemical binding]; other site 1168287012540 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287012541 galactokinase; Provisional; Region: PRK00555 1168287012542 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1168287012543 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1168287012544 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1168287012545 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1168287012546 dimer interface [polypeptide binding]; other site 1168287012547 active site 1168287012548 Predicted membrane protein [Function unknown]; Region: COG1289 1168287012549 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1168287012550 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287012551 Cytochrome P450; Region: p450; cl12078 1168287012552 hypothetical protein; Provisional; Region: PRK07588 1168287012553 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287012554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287012555 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287012556 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1168287012557 NYN domain; Region: NYN; pfam01936 1168287012558 putative metal binding site [ion binding]; other site 1168287012559 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1168287012560 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287012561 Cytochrome P450; Region: p450; cl12078 1168287012562 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1168287012563 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1168287012564 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1168287012565 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287012566 molybdopterin cofactor binding site; other site 1168287012567 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 1168287012568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1168287012569 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1168287012570 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287012571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287012572 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1168287012573 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1168287012574 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1168287012575 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1168287012576 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1168287012577 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1168287012578 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287012579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287012580 salt bridge; other site 1168287012581 non-specific DNA binding site [nucleotide binding]; other site 1168287012582 sequence-specific DNA binding site [nucleotide binding]; other site 1168287012583 heat shock protein HtpX; Provisional; Region: PRK03072 1168287012584 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1168287012585 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1168287012586 substrate binding pocket [chemical binding]; other site 1168287012587 chain length determination region; other site 1168287012588 substrate-Mg2+ binding site; other site 1168287012589 catalytic residues [active] 1168287012590 aspartate-rich region 1; other site 1168287012591 active site lid residues [active] 1168287012592 aspartate-rich region 2; other site 1168287012593 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1168287012594 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1168287012595 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287012596 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1168287012597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012598 S-adenosylmethionine binding site [chemical binding]; other site 1168287012599 short chain dehydrogenase; Provisional; Region: PRK08263 1168287012600 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1168287012601 NADP binding site [chemical binding]; other site 1168287012602 active site 1168287012603 steroid binding site; other site 1168287012604 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287012605 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1168287012606 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1168287012607 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1168287012608 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1168287012609 dimer interface [polypeptide binding]; other site 1168287012610 tetramer interface [polypeptide binding]; other site 1168287012611 PYR/PP interface [polypeptide binding]; other site 1168287012612 TPP binding site [chemical binding]; other site 1168287012613 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1168287012614 TPP-binding site; other site 1168287012615 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1168287012616 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287012617 TAP-like protein; Region: Abhydrolase_4; pfam08386 1168287012618 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1168287012619 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1168287012620 active site 1168287012621 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1168287012622 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1168287012623 active site 1168287012624 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168287012625 acyl-CoA synthetase; Validated; Region: PRK06188 1168287012626 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287012627 putative active site [active] 1168287012628 putative CoA binding site [chemical binding]; other site 1168287012629 putative AMP binding site [chemical binding]; other site 1168287012630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287012631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012632 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168287012633 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168287012634 active site 1168287012635 catalytic tetrad [active] 1168287012636 Domain of unknown function (DUF385); Region: DUF385; cl04387 1168287012637 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287012638 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1168287012639 substrate binding site [chemical binding]; other site 1168287012640 oxyanion hole (OAH) forming residues; other site 1168287012641 trimer interface [polypeptide binding]; other site 1168287012642 short chain dehydrogenase; Provisional; Region: PRK05866 1168287012643 classical (c) SDRs; Region: SDR_c; cd05233 1168287012644 NAD(P) binding site [chemical binding]; other site 1168287012645 active site 1168287012646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287012647 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1168287012648 active site 1168287012649 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1168287012650 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1168287012651 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1168287012652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287012653 acyl-activating enzyme (AAE) consensus motif; other site 1168287012654 AMP binding site [chemical binding]; other site 1168287012655 active site 1168287012656 CoA binding site [chemical binding]; other site 1168287012657 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1168287012658 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1168287012659 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1168287012660 Ligand binding site; other site 1168287012661 Putative Catalytic site; other site 1168287012662 DXD motif; other site 1168287012663 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287012664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287012665 NAD(P) binding site [chemical binding]; other site 1168287012666 active site 1168287012667 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1168287012668 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1168287012669 UbiA prenyltransferase family; Region: UbiA; pfam01040 1168287012670 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1168287012671 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1168287012672 dimer interface [polypeptide binding]; other site 1168287012673 active site 1168287012674 CoA binding pocket [chemical binding]; other site 1168287012675 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1168287012676 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168287012677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168287012678 P-loop; other site 1168287012679 Magnesium ion binding site [ion binding]; other site 1168287012680 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1168287012681 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1168287012682 ResB-like family; Region: ResB; pfam05140 1168287012683 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1168287012684 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1168287012685 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1168287012686 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168287012687 catalytic residues [active] 1168287012688 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287012689 catalytic core [active] 1168287012690 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1168287012691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168287012692 inhibitor-cofactor binding pocket; inhibition site 1168287012693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287012694 catalytic residue [active] 1168287012695 Domain of unknown function (DUF385); Region: DUF385; cl04387 1168287012696 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1168287012697 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1168287012698 metal binding site [ion binding]; metal-binding site 1168287012699 substrate binding pocket [chemical binding]; other site 1168287012700 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1168287012701 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1168287012702 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1168287012703 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168287012704 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287012705 acyl-activating enzyme (AAE) consensus motif; other site 1168287012706 AMP binding site [chemical binding]; other site 1168287012707 active site 1168287012708 CoA binding site [chemical binding]; other site 1168287012709 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1168287012710 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1168287012711 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1168287012712 putative NAD(P) binding site [chemical binding]; other site 1168287012713 active site 1168287012714 putative substrate binding site [chemical binding]; other site 1168287012715 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1168287012716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287012717 metabolite-proton symporter; Region: 2A0106; TIGR00883 1168287012718 putative substrate translocation pore; other site 1168287012719 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1168287012720 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1168287012721 active site 1168287012722 dimer interface [polypeptide binding]; other site 1168287012723 non-prolyl cis peptide bond; other site 1168287012724 insertion regions; other site 1168287012725 Putative esterase; Region: Esterase; pfam00756 1168287012726 S-formylglutathione hydrolase; Region: PLN02442 1168287012727 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287012728 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287012729 cyclase homology domain; Region: CHD; cd07302 1168287012730 nucleotidyl binding site; other site 1168287012731 metal binding site [ion binding]; metal-binding site 1168287012732 dimer interface [polypeptide binding]; other site 1168287012733 Predicted ATPase [General function prediction only]; Region: COG3903 1168287012734 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287012735 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287012736 DNA binding residues [nucleotide binding] 1168287012737 dimerization interface [polypeptide binding]; other site 1168287012738 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1168287012739 active site 1168287012740 catalytic triad [active] 1168287012741 oxyanion hole [active] 1168287012742 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287012743 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287012744 anti sigma factor interaction site; other site 1168287012745 regulatory phosphorylation site [posttranslational modification]; other site 1168287012746 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1168287012747 dimer interface [polypeptide binding]; other site 1168287012748 active site 1168287012749 Schiff base residues; other site 1168287012750 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1168287012751 active site 1168287012752 homodimer interface [polypeptide binding]; other site 1168287012753 SAM binding site [chemical binding]; other site 1168287012754 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1168287012755 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1168287012756 active site 1168287012757 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1168287012758 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1168287012759 domain interfaces; other site 1168287012760 active site 1168287012761 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1168287012762 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1168287012763 tRNA; other site 1168287012764 putative tRNA binding site [nucleotide binding]; other site 1168287012765 putative NADP binding site [chemical binding]; other site 1168287012766 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1168287012767 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1168287012768 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1168287012769 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1168287012770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287012771 motif II; other site 1168287012772 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1168287012773 active site 1168287012774 catalytic site [active] 1168287012775 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287012776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168287012777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012778 S-adenosylmethionine binding site [chemical binding]; other site 1168287012779 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168287012780 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1168287012781 putative acyl-acceptor binding pocket; other site 1168287012782 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168287012783 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1168287012784 putative NAD(P) binding site [chemical binding]; other site 1168287012785 active site 1168287012786 putative substrate binding site [chemical binding]; other site 1168287012787 DNA binding domain, excisionase family; Region: excise; TIGR01764 1168287012788 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1168287012789 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1168287012790 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1168287012791 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168287012792 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287012793 CoenzymeA binding site [chemical binding]; other site 1168287012794 subunit interaction site [polypeptide binding]; other site 1168287012795 PHB binding site; other site 1168287012796 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1168287012797 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168287012798 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1168287012799 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1168287012800 DNA interaction; other site 1168287012801 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1168287012802 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1168287012803 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168287012804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287012805 active site 1168287012806 phosphorylation site [posttranslational modification] 1168287012807 intermolecular recognition site; other site 1168287012808 dimerization interface [polypeptide binding]; other site 1168287012809 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168287012810 DNA binding site [nucleotide binding] 1168287012811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168287012812 dimer interface [polypeptide binding]; other site 1168287012813 phosphorylation site [posttranslational modification] 1168287012814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168287012815 ATP binding site [chemical binding]; other site 1168287012816 Mg2+ binding site [ion binding]; other site 1168287012817 G-X-G motif; other site 1168287012818 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287012819 catalytic core [active] 1168287012820 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168287012821 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1168287012822 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1168287012823 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1168287012824 putative ADP-binding pocket [chemical binding]; other site 1168287012825 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168287012826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287012827 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1168287012828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287012829 NAD(P) binding site [chemical binding]; other site 1168287012830 active site 1168287012831 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1168287012832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1168287012833 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1168287012834 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168287012835 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1168287012836 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287012837 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1168287012838 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1168287012839 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1168287012840 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1168287012841 putative active site [active] 1168287012842 catalytic triad [active] 1168287012843 putative dimer interface [polypeptide binding]; other site 1168287012844 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1168287012845 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1168287012846 catalytic residue [active] 1168287012847 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1168287012848 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1168287012849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287012850 non-specific DNA binding site [nucleotide binding]; other site 1168287012851 salt bridge; other site 1168287012852 sequence-specific DNA binding site [nucleotide binding]; other site 1168287012853 Predicted membrane protein [Function unknown]; Region: COG2733 1168287012854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287012855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012856 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287012857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012858 S-adenosylmethionine binding site [chemical binding]; other site 1168287012859 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1168287012860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287012861 S-adenosylmethionine binding site [chemical binding]; other site 1168287012862 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1168287012863 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1168287012864 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1168287012865 isocitrate lyase; Provisional; Region: PRK15063 1168287012866 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1168287012867 tetramer interface [polypeptide binding]; other site 1168287012868 active site 1168287012869 Mg2+/Mn2+ binding site [ion binding]; other site 1168287012870 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1168287012871 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287012872 active site 2 [active] 1168287012873 active site 1 [active] 1168287012874 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287012875 active site 2 [active] 1168287012876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168287012877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168287012878 non-specific DNA binding site [nucleotide binding]; other site 1168287012879 salt bridge; other site 1168287012880 sequence-specific DNA binding site [nucleotide binding]; other site 1168287012881 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1168287012882 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1168287012883 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1168287012884 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1168287012885 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287012886 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1168287012887 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1168287012888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287012889 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168287012890 Protein of unknown function (DUF779); Region: DUF779; cl01432 1168287012891 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1168287012892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287012893 NAD(P) binding site [chemical binding]; other site 1168287012894 catalytic residues [active] 1168287012895 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1168287012896 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287012897 enoyl-CoA hydratase; Provisional; Region: PRK12478 1168287012898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287012899 substrate binding site [chemical binding]; other site 1168287012900 oxyanion hole (OAH) forming residues; other site 1168287012901 trimer interface [polypeptide binding]; other site 1168287012902 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1168287012903 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1168287012904 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1168287012905 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1168287012906 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1168287012907 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1168287012908 dimer interface [polypeptide binding]; other site 1168287012909 putative radical transfer pathway; other site 1168287012910 diiron center [ion binding]; other site 1168287012911 tyrosyl radical; other site 1168287012912 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168287012913 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1168287012914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287012915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012916 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1168287012917 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1168287012918 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1168287012919 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168287012920 catalytic residues [active] 1168287012921 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1168287012922 DinB superfamily; Region: DinB_2; pfam12867 1168287012923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1168287012924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287012925 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1168287012926 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1168287012927 active site 1168287012928 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287012929 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287012930 PPE family; Region: PPE; pfam00823 1168287012931 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168287012932 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168287012933 classical (c) SDRs; Region: SDR_c; cd05233 1168287012934 NAD(P) binding site [chemical binding]; other site 1168287012935 active site 1168287012936 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1168287012937 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1168287012938 ring oligomerisation interface [polypeptide binding]; other site 1168287012939 ATP/Mg binding site [chemical binding]; other site 1168287012940 stacking interactions; other site 1168287012941 hinge regions; other site 1168287012942 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1168287012943 active site 1168287012944 Cupin domain; Region: Cupin_2; pfam07883 1168287012945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012946 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1168287012947 short chain dehydrogenase; Provisional; Region: PRK06197 1168287012948 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1168287012949 putative NAD(P) binding site [chemical binding]; other site 1168287012950 active site 1168287012951 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1168287012952 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1168287012953 dimer interface [polypeptide binding]; other site 1168287012954 putative functional site; other site 1168287012955 putative MPT binding site; other site 1168287012956 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1168287012957 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1168287012958 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1168287012959 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1168287012960 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1168287012961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287012962 Walker A motif; other site 1168287012963 ATP binding site [chemical binding]; other site 1168287012964 Walker B motif; other site 1168287012965 arginine finger; other site 1168287012966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287012967 Walker A motif; other site 1168287012968 ATP binding site [chemical binding]; other site 1168287012969 Walker B motif; other site 1168287012970 arginine finger; other site 1168287012971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287012972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287012973 oxidoreductase; Provisional; Region: PRK06196 1168287012974 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1168287012975 putative NAD(P) binding site [chemical binding]; other site 1168287012976 active site 1168287012977 enoyl-CoA hydratase; Provisional; Region: PRK08260 1168287012978 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287012979 substrate binding site [chemical binding]; other site 1168287012980 oxyanion hole (OAH) forming residues; other site 1168287012981 trimer interface [polypeptide binding]; other site 1168287012982 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1168287012983 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287012984 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1168287012985 carboxylate-amine ligase; Provisional; Region: PRK13517 1168287012986 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1168287012987 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1168287012988 E-class dimer interface [polypeptide binding]; other site 1168287012989 P-class dimer interface [polypeptide binding]; other site 1168287012990 active site 1168287012991 Cu2+ binding site [ion binding]; other site 1168287012992 Zn2+ binding site [ion binding]; other site 1168287012993 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168287012994 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1168287012995 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1168287012996 active site 1168287012997 catalytic residues [active] 1168287012998 metal binding site [ion binding]; metal-binding site 1168287012999 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1168287013000 putative catalytic site [active] 1168287013001 putative phosphate binding site [ion binding]; other site 1168287013002 active site 1168287013003 metal binding site A [ion binding]; metal-binding site 1168287013004 DNA binding site [nucleotide binding] 1168287013005 putative AP binding site [nucleotide binding]; other site 1168287013006 putative metal binding site B [ion binding]; other site 1168287013007 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1168287013008 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287013009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287013010 motif II; other site 1168287013011 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1168287013012 PAS fold; Region: PAS_3; pfam08447 1168287013013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1168287013014 putative active site [active] 1168287013015 heme pocket [chemical binding]; other site 1168287013016 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287013017 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1168287013018 ThiC-associated domain; Region: ThiC-associated; pfam13667 1168287013019 ThiC family; Region: ThiC; pfam01964 1168287013020 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1168287013021 dimer interface [polypeptide binding]; other site 1168287013022 substrate binding site [chemical binding]; other site 1168287013023 ATP binding site [chemical binding]; other site 1168287013024 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1168287013025 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168287013026 MarR family; Region: MarR; pfam01047 1168287013027 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1168287013028 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287013029 Predicted metalloprotease [General function prediction only]; Region: COG2321 1168287013030 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1168287013031 Beta-lactamase; Region: Beta-lactamase; pfam00144 1168287013032 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287013033 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287013034 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1168287013035 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168287013036 active site 1168287013037 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287013038 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287013039 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1168287013040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1168287013041 active site 1168287013042 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1168287013043 Peptidase family M23; Region: Peptidase_M23; pfam01551 1168287013044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013045 NAD(P) binding site [chemical binding]; other site 1168287013046 active site 1168287013047 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1168287013048 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1168287013049 PA/protease or protease-like domain interface [polypeptide binding]; other site 1168287013050 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1168287013051 Peptidase family M28; Region: Peptidase_M28; pfam04389 1168287013052 active site 1168287013053 metal binding site [ion binding]; metal-binding site 1168287013054 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1168287013055 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1168287013056 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1168287013057 PA/protease or protease-like domain interface [polypeptide binding]; other site 1168287013058 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1168287013059 active site 1168287013060 metal binding site [ion binding]; metal-binding site 1168287013061 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1168287013062 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1168287013063 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1168287013064 active site 1168287013065 catalytic triad [active] 1168287013066 oxyanion hole [active] 1168287013067 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1168287013068 ThiS interaction site; other site 1168287013069 putative active site [active] 1168287013070 tetramer interface [polypeptide binding]; other site 1168287013071 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1168287013072 thiS-thiF/thiG interaction site; other site 1168287013073 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1168287013074 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1168287013075 thiamine phosphate binding site [chemical binding]; other site 1168287013076 active site 1168287013077 pyrophosphate binding site [ion binding]; other site 1168287013078 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1168287013079 nudix motif; other site 1168287013080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168287013081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168287013082 substrate binding pocket [chemical binding]; other site 1168287013083 membrane-bound complex binding site; other site 1168287013084 hinge residues; other site 1168287013085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168287013086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168287013087 active site 1168287013088 ATP binding site [chemical binding]; other site 1168287013089 substrate binding site [chemical binding]; other site 1168287013090 activation loop (A-loop); other site 1168287013091 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1168287013092 putative active site [active] 1168287013093 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1168287013094 propionate/acetate kinase; Provisional; Region: PRK12379 1168287013095 phosphate acetyltransferase; Reviewed; Region: PRK05632 1168287013096 DRTGG domain; Region: DRTGG; pfam07085 1168287013097 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1168287013098 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1168287013099 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287013100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168287013101 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287013102 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1168287013103 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1168287013104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013105 NAD(P) binding site [chemical binding]; other site 1168287013106 active site 1168287013107 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1168287013108 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013109 FAD binding site [chemical binding]; other site 1168287013110 substrate binding pocket [chemical binding]; other site 1168287013111 catalytic base [active] 1168287013112 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013113 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287013114 active site 1168287013115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013117 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1168287013118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287013119 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1168287013120 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168287013121 homodimer interface [polypeptide binding]; other site 1168287013122 substrate-cofactor binding pocket; other site 1168287013123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287013124 catalytic residue [active] 1168287013125 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1168287013126 active site residue [active] 1168287013127 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1168287013128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013129 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168287013130 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287013131 CoenzymeA binding site [chemical binding]; other site 1168287013132 subunit interaction site [polypeptide binding]; other site 1168287013133 PHB binding site; other site 1168287013134 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1168287013135 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1168287013136 GDP-binding site [chemical binding]; other site 1168287013137 ACT binding site; other site 1168287013138 IMP binding site; other site 1168287013139 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1168287013140 catalytic core [active] 1168287013141 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1168287013142 Peptidase family M50; Region: Peptidase_M50; pfam02163 1168287013143 active site 1168287013144 putative substrate binding region [chemical binding]; other site 1168287013145 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1168287013146 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1168287013147 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1168287013148 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1168287013149 active site 1168287013150 intersubunit interface [polypeptide binding]; other site 1168287013151 zinc binding site [ion binding]; other site 1168287013152 Na+ binding site [ion binding]; other site 1168287013153 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1168287013154 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1168287013155 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1168287013156 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1168287013157 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1168287013158 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1168287013159 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168287013160 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168287013161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168287013162 active site 1168287013163 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1168287013164 classical (c) SDRs; Region: SDR_c; cd05233 1168287013165 NAD(P) binding site [chemical binding]; other site 1168287013166 active site 1168287013167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287013169 active site 1168287013170 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1168287013171 Clp amino terminal domain; Region: Clp_N; pfam02861 1168287013172 Clp amino terminal domain; Region: Clp_N; pfam02861 1168287013173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287013174 Walker A motif; other site 1168287013175 ATP binding site [chemical binding]; other site 1168287013176 Walker B motif; other site 1168287013177 arginine finger; other site 1168287013178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287013179 Walker A motif; other site 1168287013180 ATP binding site [chemical binding]; other site 1168287013181 Walker B motif; other site 1168287013182 arginine finger; other site 1168287013183 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1168287013184 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1168287013185 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1168287013186 heme-binding site [chemical binding]; other site 1168287013187 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1168287013188 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1168287013189 FAD binding pocket [chemical binding]; other site 1168287013190 FAD binding motif [chemical binding]; other site 1168287013191 phosphate binding motif [ion binding]; other site 1168287013192 beta-alpha-beta structure motif; other site 1168287013193 NAD binding pocket [chemical binding]; other site 1168287013194 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1168287013195 active site 1168287013196 catalytic residues [active] 1168287013197 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1168287013198 DNA binding residues [nucleotide binding] 1168287013199 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168287013200 putative dimer interface [polypeptide binding]; other site 1168287013201 chaperone protein DnaJ; Provisional; Region: PRK14279 1168287013202 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1168287013203 HSP70 interaction site [polypeptide binding]; other site 1168287013204 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1168287013205 Zn binding sites [ion binding]; other site 1168287013206 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1168287013207 dimer interface [polypeptide binding]; other site 1168287013208 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1168287013209 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1168287013210 dimer interface [polypeptide binding]; other site 1168287013211 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1168287013212 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1168287013213 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287013214 nucleotide binding site [chemical binding]; other site 1168287013215 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1168287013216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287013217 putative substrate translocation pore; other site 1168287013218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287013219 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287013220 nucleotide binding site [chemical binding]; other site 1168287013221 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1168287013222 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1168287013223 4Fe-4S binding domain; Region: Fer4; pfam00037 1168287013224 Cysteine-rich domain; Region: CCG; pfam02754 1168287013225 Cysteine-rich domain; Region: CCG; pfam02754 1168287013226 aminotransferase AlaT; Validated; Region: PRK09265 1168287013227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168287013228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168287013229 homodimer interface [polypeptide binding]; other site 1168287013230 catalytic residue [active] 1168287013231 YibE/F-like protein; Region: YibE_F; pfam07907 1168287013232 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1168287013233 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1168287013234 substrate binding site; other site 1168287013235 tetramer interface; other site 1168287013236 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287013237 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1168287013238 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1168287013239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287013240 S-adenosylmethionine binding site [chemical binding]; other site 1168287013241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287013242 putative substrate translocation pore; other site 1168287013243 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1168287013244 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1168287013245 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1168287013246 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1168287013247 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1168287013248 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1168287013249 trimer interface [polypeptide binding]; other site 1168287013250 active site 1168287013251 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1168287013252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1168287013253 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168287013254 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287013255 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287013256 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1168287013257 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1168287013258 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1168287013259 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287013260 nucleotide binding site [chemical binding]; other site 1168287013261 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1168287013262 active site 1168287013263 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1168287013264 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1168287013265 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1168287013266 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1168287013267 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1168287013268 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1168287013269 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1168287013270 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1168287013271 active site 1168287013272 catalytic residues [active] 1168287013273 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1168287013274 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1168287013275 NAD(P) binding site [chemical binding]; other site 1168287013276 substrate binding site [chemical binding]; other site 1168287013277 dimer interface [polypeptide binding]; other site 1168287013278 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1168287013279 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168287013280 nucleotide binding site [chemical binding]; other site 1168287013281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013283 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1168287013284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1168287013285 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1168287013286 active site 1168287013287 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1168287013288 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1168287013289 putative FMN binding site [chemical binding]; other site 1168287013290 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1168287013291 Sulfatase; Region: Sulfatase; pfam00884 1168287013292 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1168287013293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287013294 S-adenosylmethionine binding site [chemical binding]; other site 1168287013295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287013296 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287013297 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1168287013298 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1168287013299 Subtilase family; Region: Peptidase_S8; pfam00082 1168287013300 catalytic residues [active] 1168287013301 catalytic residues [active] 1168287013302 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1168287013303 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1168287013304 EspG family; Region: ESX-1_EspG; pfam14011 1168287013305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1168287013306 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287013307 PPE family; Region: PPE; pfam00823 1168287013308 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1168287013309 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287013310 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1168287013311 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287013312 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287013313 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1168287013314 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1168287013315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287013316 Walker A motif; other site 1168287013317 ATP binding site [chemical binding]; other site 1168287013318 Walker B motif; other site 1168287013319 arginine finger; other site 1168287013320 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287013321 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287013322 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1168287013323 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1168287013324 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1168287013325 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1168287013326 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1168287013327 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1168287013328 30S ribosomal protein S18; Provisional; Region: PRK13401 1168287013329 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287013330 PPE family; Region: PPE; pfam00823 1168287013331 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1168287013332 Condensation domain; Region: Condensation; pfam00668 1168287013333 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1168287013334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1168287013335 Zn binding site [ion binding]; other site 1168287013336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013338 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287013339 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287013341 active site 1168287013342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013343 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1168287013344 FAD binding site [chemical binding]; other site 1168287013345 substrate binding site [chemical binding]; other site 1168287013346 catalytic base [active] 1168287013347 acyl-CoA synthetase; Validated; Region: PRK07788 1168287013348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013349 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013350 active site 1168287013351 CoA binding site [chemical binding]; other site 1168287013352 AMP binding site [chemical binding]; other site 1168287013353 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1168287013354 nucleotide binding site [chemical binding]; other site 1168287013355 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1168287013356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287013357 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168287013358 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1168287013359 intersubunit interface [polypeptide binding]; other site 1168287013360 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1168287013361 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1168287013362 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1168287013363 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1168287013364 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1168287013365 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1168287013366 active site 1168287013367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1168287013368 DNA binding site [nucleotide binding] 1168287013369 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1168287013370 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1168287013371 putative active site [active] 1168287013372 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1168287013373 active site 1168287013374 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1168287013375 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1168287013376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287013377 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1168287013378 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1168287013379 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1168287013380 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1168287013381 putative dimer interface [polypeptide binding]; other site 1168287013382 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1168287013383 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1168287013384 tetramer interface [polypeptide binding]; other site 1168287013385 active site 1168287013386 Mg2+/Mn2+ binding site [ion binding]; other site 1168287013387 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1168287013388 L-aspartate oxidase; Provisional; Region: PRK06175 1168287013389 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1168287013390 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1168287013391 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287013392 catalytic loop [active] 1168287013393 iron binding site [ion binding]; other site 1168287013394 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1168287013395 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1168287013396 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1168287013397 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1168287013398 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1168287013399 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1168287013400 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1168287013401 FAD binding site [chemical binding]; other site 1168287013402 substrate binding site [chemical binding]; other site 1168287013403 catalytic residues [active] 1168287013404 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1168287013405 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1168287013406 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1168287013407 dimer interface [polypeptide binding]; other site 1168287013408 active site 1168287013409 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1168287013410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013411 NAD(P) binding site [chemical binding]; other site 1168287013412 active site 1168287013413 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287013414 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287013415 active site 2 [active] 1168287013416 active site 1 [active] 1168287013417 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1168287013418 Cl- selectivity filter; other site 1168287013419 Cl- binding residues [ion binding]; other site 1168287013420 pore gating glutamate residue; other site 1168287013421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013423 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1168287013424 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1168287013425 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1168287013426 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1168287013427 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1168287013428 Lipase maturation factor; Region: LMF1; pfam06762 1168287013429 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1168287013430 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168287013431 substrate binding pocket [chemical binding]; other site 1168287013432 membrane-bound complex binding site; other site 1168287013433 hinge residues; other site 1168287013434 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287013435 PPE family; Region: PPE; pfam00823 1168287013436 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1168287013437 PPE family; Region: PPE; pfam00823 1168287013438 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1168287013439 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1168287013440 formate dehydrogenase; Provisional; Region: PRK07574 1168287013441 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1168287013442 dimerization interface [polypeptide binding]; other site 1168287013443 ligand binding site [chemical binding]; other site 1168287013444 NAD binding site [chemical binding]; other site 1168287013445 catalytic site [active] 1168287013446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168287013447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287013448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1168287013449 dimerization interface [polypeptide binding]; other site 1168287013450 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1168287013451 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1168287013452 Helix-turn-helix domain; Region: HTH_20; pfam12840 1168287013453 Predicted transcriptional regulator [Transcription]; Region: COG2345 1168287013454 Suppression of tumorigenicity 7; Region: ST7; cd11557 1168287013455 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1168287013456 acetolactate synthase; Reviewed; Region: PRK08322 1168287013457 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168287013458 PYR/PP interface [polypeptide binding]; other site 1168287013459 dimer interface [polypeptide binding]; other site 1168287013460 TPP binding site [chemical binding]; other site 1168287013461 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287013462 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1168287013463 TPP-binding site [chemical binding]; other site 1168287013464 dimer interface [polypeptide binding]; other site 1168287013465 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1168287013466 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1168287013467 NAD(P) binding site [chemical binding]; other site 1168287013468 catalytic residues [active] 1168287013469 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1168287013470 active site 1168287013471 diiron metal binding site [ion binding]; other site 1168287013472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013475 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1168287013476 active site 1168287013477 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1168287013478 active site 1168287013479 substrate binding pocket [chemical binding]; other site 1168287013480 homodimer interaction site [polypeptide binding]; other site 1168287013481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013482 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1168287013483 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013484 AMP binding site [chemical binding]; other site 1168287013485 active site 1168287013486 acyl-activating enzyme (AAE) consensus motif; other site 1168287013487 acyl-activating enzyme (AAE) consensus motif; other site 1168287013488 CoA binding site [chemical binding]; other site 1168287013489 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1168287013490 O-methyltransferase; Region: Methyltransf_2; pfam00891 1168287013491 Winged helix-turn helix; Region: HTH_29; pfam13551 1168287013492 Homeodomain-like domain; Region: HTH_32; pfam13565 1168287013493 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1168287013494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1168287013495 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287013496 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1168287013497 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168287013498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168287013499 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1168287013500 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1168287013501 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1168287013502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287013503 S-adenosylmethionine binding site [chemical binding]; other site 1168287013504 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1168287013505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287013506 NAD binding site [chemical binding]; other site 1168287013507 catalytic residues [active] 1168287013508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013510 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1168287013511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013512 acyl-activating enzyme (AAE) consensus motif; other site 1168287013513 AMP binding site [chemical binding]; other site 1168287013514 active site 1168287013515 CoA binding site [chemical binding]; other site 1168287013516 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1168287013517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013519 enoyl-CoA hydratase; Provisional; Region: PRK08252 1168287013520 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287013521 substrate binding site [chemical binding]; other site 1168287013522 oxyanion hole (OAH) forming residues; other site 1168287013523 trimer interface [polypeptide binding]; other site 1168287013524 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1168287013525 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1168287013526 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1168287013527 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287013528 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287013529 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1168287013530 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1168287013531 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1168287013532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287013533 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287013534 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287013535 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287013536 active site 1168287013537 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287013538 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287013539 active site 2 [active] 1168287013540 active site 1 [active] 1168287013541 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168287013542 active site 2 [active] 1168287013543 active site 1 [active] 1168287013544 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013545 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287013546 active site 1168287013547 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1168287013548 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1168287013549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1168287013550 substrate binding site [chemical binding]; other site 1168287013551 oxyanion hole (OAH) forming residues; other site 1168287013552 trimer interface [polypeptide binding]; other site 1168287013553 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1168287013554 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013555 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287013556 acyl-activating enzyme (AAE) consensus motif; other site 1168287013557 acyl-activating enzyme (AAE) consensus motif; other site 1168287013558 putative AMP binding site [chemical binding]; other site 1168287013559 putative active site [active] 1168287013560 putative CoA binding site [chemical binding]; other site 1168287013561 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1168287013562 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1168287013563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1168287013564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1168287013565 metal binding site [ion binding]; metal-binding site 1168287013566 active site 1168287013567 I-site; other site 1168287013568 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1168287013569 active site 1168287013570 substrate-binding site [chemical binding]; other site 1168287013571 metal-binding site [ion binding] 1168287013572 GTP binding site [chemical binding]; other site 1168287013573 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1168287013574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287013575 S-adenosylmethionine binding site [chemical binding]; other site 1168287013576 LabA_like proteins; Region: LabA_like; cd06167 1168287013577 putative metal binding site [ion binding]; other site 1168287013578 MMPL family; Region: MMPL; pfam03176 1168287013579 MMPL family; Region: MMPL; pfam03176 1168287013580 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1168287013581 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1168287013582 Predicted integral membrane protein [Function unknown]; Region: COG0392 1168287013583 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1168287013584 Protein export membrane protein; Region: SecD_SecF; cl14618 1168287013585 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1168287013586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1168287013587 non-specific DNA binding site [nucleotide binding]; other site 1168287013588 salt bridge; other site 1168287013589 sequence-specific DNA binding site [nucleotide binding]; other site 1168287013590 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1168287013591 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1168287013592 active site 1168287013593 Zn binding site [ion binding]; other site 1168287013594 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1168287013595 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287013596 molybdopterin cofactor binding site; other site 1168287013597 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1168287013598 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1168287013599 putative molybdopterin cofactor binding site; other site 1168287013600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1168287013602 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1168287013603 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168287013604 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1168287013605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168287013606 putative substrate translocation pore; other site 1168287013607 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1168287013608 putative homodimer interface [polypeptide binding]; other site 1168287013609 putative homotetramer interface [polypeptide binding]; other site 1168287013610 putative allosteric switch controlling residues; other site 1168287013611 putative metal binding site [ion binding]; other site 1168287013612 putative homodimer-homodimer interface [polypeptide binding]; other site 1168287013613 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1168287013614 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1168287013615 SPW repeat; Region: SPW; pfam03779 1168287013616 SPW repeat; Region: SPW; pfam03779 1168287013617 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168287013618 FMN binding site [chemical binding]; other site 1168287013619 substrate binding site [chemical binding]; other site 1168287013620 putative catalytic residue [active] 1168287013621 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1168287013622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287013623 S-adenosylmethionine binding site [chemical binding]; other site 1168287013624 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1168287013625 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1168287013626 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1168287013627 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1168287013628 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1168287013629 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1168287013630 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1168287013631 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287013632 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1168287013633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287013634 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1168287013635 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287013636 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287013637 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168287013638 Pirin-related protein [General function prediction only]; Region: COG1741 1168287013639 Pirin; Region: Pirin; pfam02678 1168287013640 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1168287013641 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1168287013642 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1168287013643 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1168287013644 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1168287013645 RDD family; Region: RDD; pfam06271 1168287013646 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287013647 mce related protein; Region: MCE; pfam02470 1168287013648 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287013649 mce related protein; Region: MCE; pfam02470 1168287013650 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287013651 mce related protein; Region: MCE; pfam02470 1168287013652 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287013653 mce related protein; Region: MCE; pfam02470 1168287013654 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287013655 mce related protein; Region: MCE; pfam02470 1168287013656 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1168287013657 mce related protein; Region: MCE; pfam02470 1168287013658 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1168287013659 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287013660 Permease; Region: Permease; pfam02405 1168287013661 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1168287013662 Permease; Region: Permease; pfam02405 1168287013663 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1168287013664 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013665 acyl-activating enzyme (AAE) consensus motif; other site 1168287013666 AMP binding site [chemical binding]; other site 1168287013667 active site 1168287013668 CoA binding site [chemical binding]; other site 1168287013669 Predicted transcriptional regulators [Transcription]; Region: COG1725 1168287013670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287013671 DNA-binding site [nucleotide binding]; DNA binding site 1168287013672 FCD domain; Region: FCD; pfam07729 1168287013673 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1168287013674 putative hydrophobic ligand binding site [chemical binding]; other site 1168287013675 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1168287013676 active site 1168287013677 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1168287013678 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168287013679 NAD(P) binding site [chemical binding]; other site 1168287013680 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168287013681 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168287013682 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287013683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287013684 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1168287013685 classical (c) SDRs; Region: SDR_c; cd05233 1168287013686 NAD(P) binding site [chemical binding]; other site 1168287013687 active site 1168287013688 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287013689 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1168287013690 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168287013691 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287013692 NAD(P) binding site [chemical binding]; other site 1168287013693 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287013694 Cytochrome P450; Region: p450; cl12078 1168287013695 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287013696 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287013697 short chain dehydrogenase; Validated; Region: PRK08264 1168287013698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013699 NAD(P) binding site [chemical binding]; other site 1168287013700 active site 1168287013701 Domain of unknown function (DUF427); Region: DUF427; cl00998 1168287013702 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1168287013703 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287013705 active site 1168287013706 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1168287013707 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1168287013708 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1168287013709 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1168287013710 active site 1168287013711 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1168287013712 catalytic triad [active] 1168287013713 dimer interface [polypeptide binding]; other site 1168287013714 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287013715 hydrophobic ligand binding site; other site 1168287013716 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1168287013717 Strictosidine synthase; Region: Str_synth; pfam03088 1168287013718 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1168287013719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013721 Uncharacterized conserved protein [Function unknown]; Region: COG4933 1168287013722 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1168287013723 FAD binding domain; Region: FAD_binding_4; pfam01565 1168287013724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013725 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287013726 NAD(P) binding site [chemical binding]; other site 1168287013727 active site 1168287013728 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168287013729 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168287013730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168287013731 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168287013732 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1168287013733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013735 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1168287013736 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1168287013737 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1168287013738 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1168287013739 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1168287013740 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1168287013741 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1168287013742 ligand binding site [chemical binding]; other site 1168287013743 homodimer interface [polypeptide binding]; other site 1168287013744 NAD(P) binding site [chemical binding]; other site 1168287013745 trimer interface B [polypeptide binding]; other site 1168287013746 trimer interface A [polypeptide binding]; other site 1168287013747 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1168287013748 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287013749 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287013750 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287013751 active site 1168287013752 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1168287013753 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1168287013754 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1168287013755 short chain dehydrogenase; Provisional; Region: PRK07791 1168287013756 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1168287013757 NAD binding site [chemical binding]; other site 1168287013758 homodimer interface [polypeptide binding]; other site 1168287013759 active site 1168287013760 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1168287013761 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1168287013762 NAD(P) binding site [chemical binding]; other site 1168287013763 catalytic residues [active] 1168287013764 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1168287013765 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168287013766 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287013767 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287013768 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287013769 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1168287013770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013772 Pirin-related protein [General function prediction only]; Region: COG1741 1168287013773 Pirin; Region: Pirin; pfam02678 1168287013774 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1168287013775 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1168287013776 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1168287013777 dimerization interface [polypeptide binding]; other site 1168287013778 DPS ferroxidase diiron center [ion binding]; other site 1168287013779 ion pore; other site 1168287013780 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1168287013781 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168287013782 minor groove reading motif; other site 1168287013783 helix-hairpin-helix signature motif; other site 1168287013784 active site 1168287013785 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1168287013786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1168287013787 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1168287013788 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1168287013789 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1168287013790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013791 NAD(P) binding site [chemical binding]; other site 1168287013792 active site 1168287013793 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287013794 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1168287013795 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287013796 Cytochrome P450; Region: p450; cl12078 1168287013797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013799 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1168287013800 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287013801 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1168287013802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287013803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013804 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287013805 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1168287013806 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287013807 hydrophobic ligand binding site; other site 1168287013808 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1168287013809 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1168287013810 putative di-iron ligands [ion binding]; other site 1168287013811 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1168287013812 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1168287013813 FAD binding pocket [chemical binding]; other site 1168287013814 FAD binding motif [chemical binding]; other site 1168287013815 phosphate binding motif [ion binding]; other site 1168287013816 beta-alpha-beta structure motif; other site 1168287013817 NAD binding pocket [chemical binding]; other site 1168287013818 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1168287013819 catalytic loop [active] 1168287013820 iron binding site [ion binding]; other site 1168287013821 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1168287013822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287013823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1168287013824 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1168287013825 Coenzyme A binding pocket [chemical binding]; other site 1168287013826 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1168287013827 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1168287013828 Hemerythrin-like domain; Region: Hr-like; cd12108 1168287013829 Fe binding site [ion binding]; other site 1168287013830 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1168287013831 dimanganese center [ion binding]; other site 1168287013832 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1168287013833 GAF domain; Region: GAF; pfam01590 1168287013834 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1168287013835 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1168287013836 putative active site [active] 1168287013837 putative catalytic site [active] 1168287013838 Domain of unknown function DUF302; Region: DUF302; pfam03625 1168287013839 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1168287013840 active site 1168287013841 metal binding site [ion binding]; metal-binding site 1168287013842 homotetramer interface [polypeptide binding]; other site 1168287013843 MarR family; Region: MarR_2; pfam12802 1168287013844 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1168287013845 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265 1168287013846 Walker A/P-loop; other site 1168287013847 ATP binding site [chemical binding]; other site 1168287013848 Q-loop/lid; other site 1168287013849 ABC transporter signature motif; other site 1168287013850 Walker B; other site 1168287013851 D-loop; other site 1168287013852 H-loop/switch region; other site 1168287013853 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168287013854 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1168287013855 Predicted esterase [General function prediction only]; Region: COG0627 1168287013856 Predicted membrane protein [Function unknown]; Region: COG3619 1168287013857 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1168287013858 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1168287013859 trehalose synthase; Region: treS_nterm; TIGR02456 1168287013860 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1168287013861 active site 1168287013862 catalytic site [active] 1168287013863 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1168287013864 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168287013865 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1168287013866 protein binding site [polypeptide binding]; other site 1168287013867 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1168287013868 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1168287013869 elongation factor G; Reviewed; Region: PRK12740 1168287013870 G1 box; other site 1168287013871 putative GEF interaction site [polypeptide binding]; other site 1168287013872 GTP/Mg2+ binding site [chemical binding]; other site 1168287013873 Switch I region; other site 1168287013874 G2 box; other site 1168287013875 G3 box; other site 1168287013876 Switch II region; other site 1168287013877 G4 box; other site 1168287013878 G5 box; other site 1168287013879 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1168287013880 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1168287013881 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1168287013882 acyl-CoA synthetase; Validated; Region: PRK05852 1168287013883 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013885 acyl-activating enzyme (AAE) consensus motif; other site 1168287013886 acyl-activating enzyme (AAE) consensus motif; other site 1168287013887 AMP binding site [chemical binding]; other site 1168287013888 active site 1168287013889 CoA binding site [chemical binding]; other site 1168287013890 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1168287013891 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168287013892 PYR/PP interface [polypeptide binding]; other site 1168287013893 dimer interface [polypeptide binding]; other site 1168287013894 TPP binding site [chemical binding]; other site 1168287013895 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287013896 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1168287013897 TPP-binding site; other site 1168287013898 dimer interface [polypeptide binding]; other site 1168287013899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168287013900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287013901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1168287013902 dimerization interface [polypeptide binding]; other site 1168287013903 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1168287013904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1168287013905 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168287013906 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168287013907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013908 acyl-activating enzyme (AAE) consensus motif; other site 1168287013909 AMP binding site [chemical binding]; other site 1168287013910 active site 1168287013911 CoA binding site [chemical binding]; other site 1168287013912 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1168287013913 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1168287013914 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1168287013915 putative NAD(P) binding site [chemical binding]; other site 1168287013916 active site 1168287013917 putative substrate binding site [chemical binding]; other site 1168287013918 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168287013919 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1168287013920 putative NAD(P) binding site [chemical binding]; other site 1168287013921 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1168287013922 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1168287013923 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1168287013924 S-adenosylmethionine binding site [chemical binding]; other site 1168287013925 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287013926 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168287013927 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1168287013928 active site 1168287013929 catalytic triad [active] 1168287013930 oxyanion hole [active] 1168287013931 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1168287013932 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1168287013933 NAD binding site [chemical binding]; other site 1168287013934 catalytic residues [active] 1168287013935 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1168287013936 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168287013937 PYR/PP interface [polypeptide binding]; other site 1168287013938 dimer interface [polypeptide binding]; other site 1168287013939 TPP binding site [chemical binding]; other site 1168287013940 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168287013941 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1168287013942 TPP-binding site; other site 1168287013943 dimer interface [polypeptide binding]; other site 1168287013944 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287013945 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287013946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287013947 NAD(P) binding site [chemical binding]; other site 1168287013948 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1168287013949 active site 1168287013950 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287013951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287013952 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287013953 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287013954 [2Fe-2S] cluster binding site [ion binding]; other site 1168287013955 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1168287013956 putative alpha subunit interface [polypeptide binding]; other site 1168287013957 putative active site [active] 1168287013958 putative substrate binding site [chemical binding]; other site 1168287013959 Fe binding site [ion binding]; other site 1168287013960 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1168287013961 classical (c) SDRs; Region: SDR_c; cd05233 1168287013962 NAD(P) binding site [chemical binding]; other site 1168287013963 active site 1168287013964 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1168287013965 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1168287013966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168287013967 DNA-binding site [nucleotide binding]; DNA binding site 1168287013968 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1168287013969 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1168287013970 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1168287013971 acyl-activating enzyme (AAE) consensus motif; other site 1168287013972 putative AMP binding site [chemical binding]; other site 1168287013973 putative active site [active] 1168287013974 putative CoA binding site [chemical binding]; other site 1168287013975 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1168287013976 classical (c) SDRs; Region: SDR_c; cd05233 1168287013977 NAD(P) binding site [chemical binding]; other site 1168287013978 active site 1168287013979 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1168287013980 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287013981 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1168287013982 acyl-activating enzyme (AAE) consensus motif; other site 1168287013983 acyl-activating enzyme (AAE) consensus motif; other site 1168287013984 putative AMP binding site [chemical binding]; other site 1168287013985 putative active site [active] 1168287013986 putative CoA binding site [chemical binding]; other site 1168287013987 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1168287013988 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1168287013989 NAD binding site [chemical binding]; other site 1168287013990 catalytic Zn binding site [ion binding]; other site 1168287013991 substrate binding site [chemical binding]; other site 1168287013992 structural Zn binding site [ion binding]; other site 1168287013993 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1168287013994 hydrophobic ligand binding site; other site 1168287013995 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287013996 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287013997 Integrase core domain; Region: rve; pfam00665 1168287013998 SnoaL-like domain; Region: SnoaL_2; pfam12680 1168287013999 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1168287014000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287014001 NAD(P) binding site [chemical binding]; other site 1168287014002 active site 1168287014003 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1168287014004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287014005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287014006 DNA binding residues [nucleotide binding] 1168287014007 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1168287014008 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287014009 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1168287014010 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1168287014011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168287014012 motif II; other site 1168287014013 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1168287014014 acyl-CoA synthetase; Provisional; Region: PRK13383 1168287014015 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287014016 acyl-activating enzyme (AAE) consensus motif; other site 1168287014017 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287014018 AMP binding site [chemical binding]; other site 1168287014019 active site 1168287014020 acyl-activating enzyme (AAE) consensus motif; other site 1168287014021 CoA binding site [chemical binding]; other site 1168287014022 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168287014023 classical (c) SDRs; Region: SDR_c; cd05233 1168287014024 NAD(P) binding site [chemical binding]; other site 1168287014025 active site 1168287014026 Cutinase; Region: Cutinase; pfam01083 1168287014027 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1168287014028 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1168287014029 putative NAD(P) binding site [chemical binding]; other site 1168287014030 active site 1168287014031 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1168287014032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287014033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287014034 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287014035 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1168287014036 cyclase homology domain; Region: CHD; cd07302 1168287014037 nucleotidyl binding site; other site 1168287014038 metal binding site [ion binding]; metal-binding site 1168287014039 dimer interface [polypeptide binding]; other site 1168287014040 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287014041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287014042 S-adenosylmethionine binding site [chemical binding]; other site 1168287014043 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1168287014044 hydrophobic ligand binding site; other site 1168287014045 short chain dehydrogenase; Validated; Region: PRK08264 1168287014046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287014047 NAD(P) binding site [chemical binding]; other site 1168287014048 active site 1168287014049 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1168287014050 CGNR zinc finger; Region: zf-CGNR; pfam11706 1168287014051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168287014052 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1168287014053 S-adenosylmethionine binding site [chemical binding]; other site 1168287014054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287014055 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1168287014056 NAD(P) binding site [chemical binding]; other site 1168287014057 active site 1168287014058 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1168287014059 CoenzymeA binding site [chemical binding]; other site 1168287014060 subunit interaction site [polypeptide binding]; other site 1168287014061 PHB binding site; other site 1168287014062 Predicted membrane protein [Function unknown]; Region: COG3305 1168287014063 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1168287014064 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168287014065 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1168287014066 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1168287014067 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168287014068 putative NAD(P) binding site [chemical binding]; other site 1168287014069 catalytic Zn binding site [ion binding]; other site 1168287014070 SnoaL-like domain; Region: SnoaL_4; pfam13577 1168287014071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287014072 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1168287014073 NAD(P) binding site [chemical binding]; other site 1168287014074 active site 1168287014075 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1168287014076 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1168287014077 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1168287014078 classical (c) SDRs; Region: SDR_c; cd05233 1168287014079 NAD(P) binding site [chemical binding]; other site 1168287014080 active site 1168287014081 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1168287014082 Cytochrome P450; Region: p450; cl12078 1168287014083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287014084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287014085 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1168287014086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1168287014087 Protein of unknown function, DUF417; Region: DUF417; cl01162 1168287014088 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1168287014089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287014090 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1168287014091 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1168287014092 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1168287014093 putative hydrophobic ligand binding site [chemical binding]; other site 1168287014094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168287014095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168287014096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1168287014097 dimerization interface [polypeptide binding]; other site 1168287014098 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1168287014099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168287014100 NAD(P) binding site [chemical binding]; other site 1168287014101 active site 1168287014102 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1168287014103 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1168287014104 classical (c) SDRs; Region: SDR_c; cd05233 1168287014105 NAD(P) binding site [chemical binding]; other site 1168287014106 active site 1168287014107 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1168287014108 classical (c) SDRs; Region: SDR_c; cd05233 1168287014109 NAD(P) binding site [chemical binding]; other site 1168287014110 active site 1168287014111 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1168287014112 metal-binding site [ion binding] 1168287014113 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168287014114 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1168287014115 metal-binding site [ion binding] 1168287014116 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168287014117 Predicted esterase [General function prediction only]; Region: COG0627 1168287014118 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1168287014119 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1168287014120 NodB motif; other site 1168287014121 active site 1168287014122 catalytic site [active] 1168287014123 metal binding site [ion binding]; metal-binding site 1168287014124 Secretory lipase; Region: LIP; pfam03583 1168287014125 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1168287014126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1168287014127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287014128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287014129 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168287014130 Helix-turn-helix domain; Region: HTH_38; pfam13936 1168287014131 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1168287014132 Integrase core domain; Region: rve; pfam00665 1168287014133 classical (c) SDRs; Region: SDR_c; cd05233 1168287014134 NAD(P) binding site [chemical binding]; other site 1168287014135 active site 1168287014136 acyl-CoA synthetase; Provisional; Region: PRK13388 1168287014137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1168287014138 acyl-activating enzyme (AAE) consensus motif; other site 1168287014139 AMP binding site [chemical binding]; other site 1168287014140 active site 1168287014141 CoA binding site [chemical binding]; other site 1168287014142 Predicted transcriptional regulators [Transcription]; Region: COG1695 1168287014143 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287014144 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287014145 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287014146 active site 1168287014147 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287014148 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287014149 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1168287014150 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168287014151 Amidohydrolase; Region: Amidohydro_2; pfam04909 1168287014152 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168287014153 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168287014154 DNA binding site [nucleotide binding] 1168287014155 domain linker motif; other site 1168287014156 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1168287014157 dimerization interface [polypeptide binding]; other site 1168287014158 ligand binding site [chemical binding]; other site 1168287014159 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1168287014160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168287014161 Walker A motif; other site 1168287014162 ATP binding site [chemical binding]; other site 1168287014163 Walker B motif; other site 1168287014164 arginine finger; other site 1168287014165 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1168287014166 DUF35 OB-fold domain; Region: DUF35; pfam01796 1168287014167 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1168287014168 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1168287014169 active site 1168287014170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287014171 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1168287014172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287014173 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1168287014174 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1168287014175 active site 1168287014176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287014177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287014178 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1168287014179 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1168287014180 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1168287014181 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1168287014182 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1168287014183 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 1168287014184 putative active site [active] 1168287014185 catalytic residue [active] 1168287014186 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1168287014187 anti sigma factor interaction site; other site 1168287014188 regulatory phosphorylation site [posttranslational modification]; other site 1168287014189 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1168287014190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1168287014191 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1168287014192 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287014193 putative active site [active] 1168287014194 ATP binding site [chemical binding]; other site 1168287014195 putative substrate binding site [chemical binding]; other site 1168287014196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168287014197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168287014198 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1168287014199 Phosphotransferase enzyme family; Region: APH; pfam01636 1168287014200 Ecdysteroid kinase; Region: EcKinase; cl17738 1168287014201 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1168287014202 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1168287014203 active site 1168287014204 putative substrate binding pocket [chemical binding]; other site 1168287014205 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1168287014206 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1168287014207 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1168287014208 [2Fe-2S] cluster binding site [ion binding]; other site 1168287014209 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1168287014210 putative alpha subunit interface [polypeptide binding]; other site 1168287014211 putative active site [active] 1168287014212 putative substrate binding site [chemical binding]; other site 1168287014213 Fe binding site [ion binding]; other site 1168287014214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168287014215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168287014216 active site 1168287014217 phosphorylation site [posttranslational modification] 1168287014218 intermolecular recognition site; other site 1168287014219 dimerization interface [polypeptide binding]; other site 1168287014220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168287014221 DNA binding residues [nucleotide binding] 1168287014222 dimerization interface [polypeptide binding]; other site 1168287014223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168287014224 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1168287014225 Transport protein; Region: actII; TIGR00833 1168287014226 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1168287014227 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287014228 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1168287014229 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287014230 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168287014231 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1168287014232 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1168287014233 catalytic residue [active] 1168287014234 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1168287014235 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1168287014236 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1168287014237 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1168287014238 active site 1168287014239 NTP binding site [chemical binding]; other site 1168287014240 metal binding triad [ion binding]; metal-binding site 1168287014241 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1168287014242 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168287014243 Zn2+ binding site [ion binding]; other site 1168287014244 Mg2+ binding site [ion binding]; other site 1168287014245 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1168287014246 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1168287014247 active site 1168287014248 Ap6A binding site [chemical binding]; other site 1168287014249 nudix motif; other site 1168287014250 metal binding site [ion binding]; metal-binding site 1168287014251 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1168287014252 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1168287014253 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1168287014254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168287014255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168287014256 DNA binding residues [nucleotide binding] 1168287014257 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1168287014258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168287014259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168287014260 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1168287014261 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168287014262 catalytic residues [active] 1168287014263 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1168287014264 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1168287014265 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1168287014266 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1168287014267 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1168287014268 active site 1168287014269 metal binding site [ion binding]; metal-binding site 1168287014270 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1168287014271 ParB-like nuclease domain; Region: ParBc; pfam02195 1168287014272 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1168287014273 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168287014274 P-loop; other site 1168287014275 Magnesium ion binding site [ion binding]; other site 1168287014276 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168287014277 Magnesium ion binding site [ion binding]; other site 1168287014278 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168287014279 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1168287014280 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1168287014281 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1168287014282 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1168287014283 G-X-X-G motif; other site 1168287014284 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1168287014285 RxxxH motif; other site 1168287014286 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1168287014287 hypothetical protein; Validated; Region: PRK00041 1168287014288 Ribonuclease P; Region: Ribonuclease_P; cl00457 1168287014289 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399