-- dump date   	20111121_013244
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
582744000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
582744000002	hypothetical protein; Validated; Region: PRK06672
582744000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744000004	Walker A motif; other site
582744000005	ATP binding site [chemical binding]; other site
582744000006	Walker B motif; other site
582744000007	arginine finger; other site
582744000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
582744000009	DnaA box-binding interface [nucleotide binding]; other site
582744000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
582744000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
582744000012	putative DNA binding surface [nucleotide binding]; other site
582744000013	dimer interface [polypeptide binding]; other site
582744000014	beta-clamp/clamp loader binding surface; other site
582744000015	beta-clamp/translesion DNA polymerase binding surface; other site
582744000016	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
582744000017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
582744000018	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
582744000019	anchoring element; other site
582744000020	dimer interface [polypeptide binding]; other site
582744000021	ATP binding site [chemical binding]; other site
582744000022	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
582744000023	active site
582744000024	putative metal-binding site [ion binding]; other site
582744000025	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
582744000026	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
582744000027	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
582744000028	G1 box; other site
582744000029	GTP/Mg2+ binding site [chemical binding]; other site
582744000030	Switch I region; other site
582744000031	G2 box; other site
582744000032	G3 box; other site
582744000033	Switch II region; other site
582744000034	G4 box; other site
582744000035	G5 box; other site
582744000036	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
582744000037	ATP binding site [chemical binding]; other site
582744000038	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
582744000039	CrcB-like protein; Region: CRCB; cl09114
582744000040	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
582744000041	Predicted dehydrogenase [General function prediction only]; Region: COG0579
582744000042	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
582744000043	domain; Region: Glyco_hydro_2; pfam00703
582744000044	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895
582744000045	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
582744000046	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744000047	putative substrate translocation pore; other site
582744000048	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582744000049	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744000050	putative active site [active]
582744000051	heme pocket [chemical binding]; other site
582744000052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744000053	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582744000054	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744000055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744000056	PAS fold; Region: PAS_4; pfam08448
582744000057	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582744000058	GAF domain; Region: GAF; cl00853
582744000059	PAS fold; Region: PAS_4; pfam08448
582744000060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744000061	putative active site [active]
582744000062	heme pocket [chemical binding]; other site
582744000063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744000064	metal binding site [ion binding]; metal-binding site
582744000065	active site
582744000066	I-site; other site
582744000067	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744000068	Cytochrome c; Region: Cytochrom_C; cl11414
582744000069	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582744000070	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
582744000071	Trp docking motif; other site
582744000072	'Velcro' closure; other site
582744000073	active site
582744000074	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
582744000075	GAF domain; Region: GAF; cl00853
582744000076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744000077	Walker A motif; other site
582744000078	ATP binding site [chemical binding]; other site
582744000079	Walker B motif; other site
582744000080	arginine finger; other site
582744000081	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744000082	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
582744000083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744000084	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
582744000085	dimerization interface [polypeptide binding]; other site
582744000086	coenzyme PQQ biosynthesis protein A; Provisional; Region: PRK14763
582744000087	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
582744000088	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
582744000089	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
582744000090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744000091	S-adenosylmethionine binding site [chemical binding]; other site
582744000092	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
582744000093	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582744000094	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744000095	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
582744000096	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
582744000097	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
582744000098	carboxyltransferase (CT) interaction site; other site
582744000099	biotinylation site [posttranslational modification]; other site
582744000100	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
582744000101	trimer interface [polypeptide binding]; other site
582744000102	active site
582744000103	dimer interface [polypeptide binding]; other site
582744000104	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
582744000105	catalytic residues [active]
582744000106	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
582744000107	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
582744000108	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
582744000109	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
582744000110	DsbD alpha interface [polypeptide binding]; other site
582744000111	catalytic residues [active]
582744000112	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
582744000113	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
582744000114	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
582744000115	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582744000116	catalytic loop [active]
582744000117	iron binding site [ion binding]; other site
582744000118	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189
582744000119	FAD binding pocket [chemical binding]; other site
582744000120	FAD binding motif [chemical binding]; other site
582744000121	phosphate binding motif [ion binding]; other site
582744000122	beta-alpha-beta structure motif; other site
582744000123	NAD binding pocket [chemical binding]; other site
582744000124	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
582744000125	HemY protein N-terminus; Region: HemY_N; pfam07219
582744000126	HemX; Region: HemX; cl14667
582744000127	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
582744000128	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578
582744000129	active site
582744000130	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
582744000131	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
582744000132	domain interfaces; other site
582744000133	active site
582744000134	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
582744000135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744000136	active site
582744000137	phosphorylation site [posttranslational modification]
582744000138	intermolecular recognition site; other site
582744000139	dimerization interface [polypeptide binding]; other site
582744000140	LytTr DNA-binding domain; Region: LytTR; cl04498
582744000141	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
582744000142	Histidine kinase; Region: His_kinase; pfam06580
582744000143	argininosuccinate lyase; Provisional; Region: PRK00855
582744000144	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
582744000145	active sites [active]
582744000146	tetramer interface [polypeptide binding]; other site
582744000147	Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889
582744000148	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
582744000149	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
582744000150	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
582744000151	DXD motif; other site
582744000152	PilZ domain; Region: PilZ; cl01260
582744000153	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
582744000154	cellulose synthase regulator protein; Provisional; Region: PRK11114
582744000155	cyclase homology domain; Region: CHD; cd07302
582744000156	metal binding site [ion binding]; metal-binding site
582744000157	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
582744000158	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
582744000159	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
582744000160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744000161	FeS/SAM binding site; other site
582744000162	HemN C-terminal region; Region: HemN_C; pfam06969
582744000163	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
582744000164	active site
582744000165	dimerization interface [polypeptide binding]; other site
582744000166	ribonuclease PH; Reviewed; Region: rph; PRK00173
582744000167	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
582744000168	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
582744000169	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
582744000170	Active site [active]
582744000171	Protein kinase domain; Region: Pkinase; pfam00069
582744000172	Catalytic domain of Protein Kinases; Region: PKc; cd00180
582744000173	active site
582744000174	ATP binding site [chemical binding]; other site
582744000175	substrate binding site [chemical binding]; other site
582744000176	activation loop (A-loop); other site
582744000177	hypothetical protein; Provisional; Region: PRK11820
582744000178	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
582744000179	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
582744000180	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
582744000181	catalytic site [active]
582744000182	G-X2-G-X-G-K; other site
582744000183	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
582744000184	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
582744000185	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744000186	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
582744000187	synthetase active site [active]
582744000188	NTP binding site [chemical binding]; other site
582744000189	metal binding site [ion binding]; metal-binding site
582744000190	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
582744000191	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
582744000192	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
582744000193	homotrimer interaction site [polypeptide binding]; other site
582744000194	putative active site [active]
582744000195	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
582744000196	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
582744000197	generic binding surface II; other site
582744000198	ssDNA binding site; other site
582744000199	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582744000200	ATP binding site [chemical binding]; other site
582744000201	putative Mg++ binding site [ion binding]; other site
582744000202	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744000203	nucleotide binding region [chemical binding]; other site
582744000204	ATP-binding site [chemical binding]; other site
582744000205	Chorismate lyase; Region: Chor_lyase; cl01230
582744000206	UbiA prenyltransferase family; Region: UbiA; cl00337
582744000207	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
582744000208	23S rRNA interface [nucleotide binding]; other site
582744000209	L3 interface [polypeptide binding]; other site
582744000210	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
582744000211	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
582744000212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744000213	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
582744000214	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
582744000215	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
582744000216	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
582744000217	dimer interface [polypeptide binding]; other site
582744000218	Citrate synthase; Region: Citrate_synt; pfam00285
582744000219	active site
582744000220	citrylCoA binding site [chemical binding]; other site
582744000221	NADH binding [chemical binding]; other site
582744000222	cationic pore residues; other site
582744000223	oxalacetate/citrate binding site [chemical binding]; other site
582744000224	coenzyme A binding site [chemical binding]; other site
582744000225	catalytic triad [active]
582744000226	Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217
582744000227	putative peptidase; Provisional; Region: PRK11649
582744000228	Peptidase family M23; Region: Peptidase_M23; pfam01551
582744000229	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
582744000230	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
582744000231	active site
582744000232	HIGH motif; other site
582744000233	dimer interface [polypeptide binding]; other site
582744000234	KMSKS motif; other site
582744000235	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
582744000236	ribosome maturation protein RimP; Reviewed; Region: PRK00092
582744000237	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
582744000238	Sm1 motif; other site
582744000239	predicted subunit interaction site [polypeptide binding]; other site
582744000240	RNA binding pocket [nucleotide binding]; other site
582744000241	Sm2 motif; other site
582744000242	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
582744000243	NusA N-terminal domain; Region: NusA_N; pfam08529
582744000244	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
582744000245	RNA binding site [nucleotide binding]; other site
582744000246	homodimer interface [polypeptide binding]; other site
582744000247	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
582744000248	G-X-X-G motif; other site
582744000249	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
582744000250	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
582744000251	translation initiation factor IF-2; Validated; Region: infB; PRK05306
582744000252	translation initiation factor IF-2; Region: IF-2; TIGR00487
582744000253	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
582744000254	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
582744000255	G1 box; other site
582744000256	putative GEF interaction site [polypeptide binding]; other site
582744000257	GTP/Mg2+ binding site [chemical binding]; other site
582744000258	Switch I region; other site
582744000259	G2 box; other site
582744000260	G3 box; other site
582744000261	Switch II region; other site
582744000262	G4 box; other site
582744000263	G5 box; other site
582744000264	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
582744000265	Translation-initiation factor 2; Region: IF-2; pfam11987
582744000266	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
582744000267	Ribosome-binding factor A; Region: RBFA; cl00542
582744000268	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
582744000269	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
582744000270	RNA binding site [nucleotide binding]; other site
582744000271	active site
582744000272	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
582744000273	16S/18S rRNA binding site [nucleotide binding]; other site
582744000274	S13e-L30e interaction site [polypeptide binding]; other site
582744000275	25S rRNA binding site [nucleotide binding]; other site
582744000276	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
582744000277	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
582744000278	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
582744000279	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
582744000280	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
582744000281	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
582744000282	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
582744000283	putative nucleic acid binding region [nucleotide binding]; other site
582744000284	G-X-X-G motif; other site
582744000285	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
582744000286	RNA binding site [nucleotide binding]; other site
582744000287	domain interface; other site
582744000288	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
582744000289	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
582744000290	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
582744000291	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
582744000292	homodimer interface [polypeptide binding]; other site
582744000293	NADP binding site [chemical binding]; other site
582744000294	substrate binding site [chemical binding]; other site
582744000295	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582744000296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744000297	active site
582744000298	phosphorylation site [posttranslational modification]
582744000299	intermolecular recognition site; other site
582744000300	dimerization interface [polypeptide binding]; other site
582744000301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744000302	Walker A motif; other site
582744000303	ATP binding site [chemical binding]; other site
582744000304	Walker B motif; other site
582744000305	arginine finger; other site
582744000306	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744000307	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744000308	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
582744000309	Sporulation related domain; Region: SPOR; cl10051
582744000310	Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450
582744000311	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
582744000312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000313	TPR motif; other site
582744000314	binding surface
582744000315	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
582744000316	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
582744000317	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
582744000318	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
582744000319	Walker A motif; other site
582744000320	ATP binding site [chemical binding]; other site
582744000321	Walker B motif; other site
582744000322	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
582744000323	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744000324	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744000325	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
582744000326	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
582744000327	ATP binding site [chemical binding]; other site
582744000328	substrate interface [chemical binding]; other site
582744000329	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
582744000330	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
582744000331	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
582744000332	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
582744000333	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
582744000334	HIGH motif; other site
582744000335	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
582744000336	active site
582744000337	KMSKS motif; other site
582744000338	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
582744000339	tRNA binding surface [nucleotide binding]; other site
582744000340	anticodon binding site; other site
582744000341	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
582744000342	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291
582744000343	CPxP  motif; other site
582744000344	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
582744000345	active site residue [active]
582744000346	Bacterial sugar transferase; Region: Bac_transf; cl00939
582744000347	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582744000348	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744000349	Walker A motif; other site
582744000350	ATP binding site [chemical binding]; other site
582744000351	Walker B motif; other site
582744000352	arginine finger; other site
582744000353	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
582744000354	active site
582744000355	intersubunit interface [polypeptide binding]; other site
582744000356	Zn2+ binding site [ion binding]; other site
582744000357	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582744000358	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744000359	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
582744000360	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582744000361	substrate binding pocket [chemical binding]; other site
582744000362	membrane-bound complex binding site; other site
582744000363	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
582744000364	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
582744000365	Walker A/P-loop; other site
582744000366	ATP binding site [chemical binding]; other site
582744000367	Q-loop/lid; other site
582744000368	ABC transporter signature motif; other site
582744000369	Walker B; other site
582744000370	D-loop; other site
582744000371	H-loop/switch region; other site
582744000372	Gram-negative bacterial tonB protein; Region: TonB; cl10048
582744000373	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
582744000374	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582744000375	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
582744000376	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
582744000377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
582744000378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744000379	dimer interface [polypeptide binding]; other site
582744000380	conserved gate region; other site
582744000381	putative PBP binding loops; other site
582744000382	ABC-ATPase subunit interface; other site
582744000383	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744000384	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744000385	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744000386	N-terminal plug; other site
582744000387	ligand-binding site [chemical binding]; other site
582744000388	choline dehydrogenase; Validated; Region: PRK02106
582744000389	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744000390	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
582744000391	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
582744000392	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
582744000393	NAD(P) binding site [chemical binding]; other site
582744000394	catalytic residues [active]
582744000395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744000396	putative substrate translocation pore; other site
582744000397	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
582744000398	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
582744000399	dimer interface [polypeptide binding]; other site
582744000400	decamer (pentamer of dimers) interface [polypeptide binding]; other site
582744000401	catalytic triad [active]
582744000402	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582744000403	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744000404	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
582744000405	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
582744000406	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254
582744000407	Walker A/P-loop; other site
582744000408	ATP binding site [chemical binding]; other site
582744000409	Q-loop/lid; other site
582744000410	ABC transporter signature motif; other site
582744000411	Walker B; other site
582744000412	D-loop; other site
582744000413	H-loop/switch region; other site
582744000414	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
582744000415	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
582744000416	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744000417	Walker A/P-loop; other site
582744000418	ATP binding site [chemical binding]; other site
582744000419	Q-loop/lid; other site
582744000420	ABC transporter signature motif; other site
582744000421	Walker B; other site
582744000422	D-loop; other site
582744000423	H-loop/switch region; other site
582744000424	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744000425	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744000426	N-terminal plug; other site
582744000427	ligand-binding site [chemical binding]; other site
582744000428	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
582744000429	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
582744000430	putative FMN binding site [chemical binding]; other site
582744000431	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
582744000432	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
582744000433	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
582744000434	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
582744000435	dimer interface [polypeptide binding]; other site
582744000436	active site
582744000437	non-prolyl cis peptide bond; other site
582744000438	insertion regions; other site
582744000439	PAS domain S-box; Region: sensory_box; TIGR00229
582744000440	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744000441	putative active site [active]
582744000442	heme pocket [chemical binding]; other site
582744000443	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582744000444	GAF domain; Region: GAF; cl00853
582744000445	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744000446	metal binding site [ion binding]; metal-binding site
582744000447	active site
582744000448	I-site; other site
582744000449	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582744000450	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
582744000451	putative NAD(P) binding site [chemical binding]; other site
582744000452	active site
582744000453	putative substrate binding site [chemical binding]; other site
582744000454	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
582744000455	Probable Catalytic site [active]
582744000456	metal binding site [ion binding]; metal-binding site
582744000457	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
582744000458	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582744000459	active site
582744000460	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
582744000461	Probable Catalytic site [active]
582744000462	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156
582744000463	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
582744000464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744000465	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156
582744000466	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
582744000467	ligand binding site [chemical binding]; other site
582744000468	tetramer interface [polypeptide binding]; other site
582744000469	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
582744000470	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
582744000471	NeuB family; Region: NeuB; cl00496
582744000472	SAF domain; Region: SAF; cl00555
582744000473	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
582744000474	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
582744000475	Metal-binding active site; metal-binding site
582744000476	AP (apurinic/apyrimidinic) site pocket; other site
582744000477	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
582744000478	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744000479	Walker A/P-loop; other site
582744000480	ATP binding site [chemical binding]; other site
582744000481	Q-loop/lid; other site
582744000482	ABC transporter signature motif; other site
582744000483	Walker B; other site
582744000484	D-loop; other site
582744000485	H-loop/switch region; other site
582744000486	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
582744000487	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
582744000488	active site pocket [active]
582744000489	putative dimer interface [polypeptide binding]; other site
582744000490	putative cataytic base [active]
582744000491	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
582744000492	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582744000493	catalytic core [active]
582744000494	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000495	binding surface
582744000496	TPR motif; other site
582744000497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000498	binding surface
582744000499	TPR motif; other site
582744000500	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
582744000501	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582744000502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000503	TPR motif; other site
582744000504	binding surface
582744000505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000506	TPR motif; other site
582744000507	binding surface
582744000508	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000509	binding surface
582744000510	TPR motif; other site
582744000511	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000512	binding surface
582744000513	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582744000514	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
582744000515	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744000516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744000517	homodimer interface [polypeptide binding]; other site
582744000518	catalytic residue [active]
582744000519	CobD/Cbib protein; Region: CobD_Cbib; cl00561
582744000520	cobyric acid synthase; Provisional; Region: PRK00784
582744000521	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744000522	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
582744000523	catalytic triad [active]
582744000524	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
582744000525	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544
582744000526	homotrimer interface [polypeptide binding]; other site
582744000527	Walker A motif; other site
582744000528	GTP binding site [chemical binding]; other site
582744000529	Walker B motif; other site
582744000530	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144
582744000531	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
582744000532	cobalamin binding residues [chemical binding]; other site
582744000533	putative BtuC binding residues; other site
582744000534	dimer interface [polypeptide binding]; other site
582744000535	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145
582744000536	putative FMN binding site [chemical binding]; other site
582744000537	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
582744000538	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
582744000539	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
582744000540	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744000541	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
582744000542	catalytic triad [active]
582744000543	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
582744000544	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
582744000545	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561
582744000546	homodimer interface [polypeptide binding]; other site
582744000547	Walker A motif; other site
582744000548	ATP binding site [chemical binding]; other site
582744000549	hydroxycobalamin binding site [chemical binding]; other site
582744000550	Walker B motif; other site
582744000551	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582744000552	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744000553	N-terminal plug; other site
582744000554	ligand-binding site [chemical binding]; other site
582744000555	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
582744000556	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744000557	N-terminal plug; other site
582744000558	ligand-binding site [chemical binding]; other site
582744000559	Cell division protein ZapA; Region: ZapA; cl01146
582744000560	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
582744000561	EVE domain; Region: EVE; cl00728
582744000562	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
582744000563	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
582744000564	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567
582744000565	structural tetrad; other site
582744000566	threonine dehydratase; Reviewed; Region: PRK09224
582744000567	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
582744000568	tetramer interface [polypeptide binding]; other site
582744000569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744000570	catalytic residue [active]
582744000571	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
582744000572	putative Ile/Val binding site [chemical binding]; other site
582744000573	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
582744000574	putative Ile/Val binding site [chemical binding]; other site
582744000575	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
582744000576	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582744000577	active site
582744000578	dimer interface [polypeptide binding]; other site
582744000579	transcriptional regulator PhoU; Provisional; Region: PRK11115
582744000580	PhoU domain; Region: PhoU; pfam01895
582744000581	PhoU domain; Region: PhoU; pfam01895
582744000582	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
582744000583	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
582744000584	polyphosphate kinase; Provisional; Region: PRK05443
582744000585	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
582744000586	putative domain interface [polypeptide binding]; other site
582744000587	putative active site [active]
582744000588	catalytic site [active]
582744000589	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
582744000590	putative domain interface [polypeptide binding]; other site
582744000591	putative active site [active]
582744000592	catalytic site [active]
582744000593	Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104
582744000594	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
582744000595	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744000596	N-terminal plug; other site
582744000597	ligand-binding site [chemical binding]; other site
582744000598	superoxide dismutase; Provisional; Region: PRK10543
582744000599	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
582744000600	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
582744000601	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
582744000602	N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
582744000603	Int/Topo IB signature motif; other site
582744000604	active site
582744000605	Protein of unknown function, DUF484; Region: DUF484; cl01228
582744000606	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
582744000607	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
582744000608	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
582744000609	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
582744000610	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
582744000611	putative acyl-acceptor binding pocket; other site
582744000612	S-adenosylmethionine synthetase; Validated; Region: PRK05250
582744000613	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
582744000614	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
582744000615	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
582744000616	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
582744000617	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582744000618	Zn2+ binding site [ion binding]; other site
582744000619	Mg2+ binding site [ion binding]; other site
582744000620	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
582744000621	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401
582744000622	oligomerization interface [polypeptide binding]; other site
582744000623	active site
582744000624	NAD+ binding site [chemical binding]; other site
582744000625	Membrane protein of unknown function; Region: DUF360; cl00850
582744000626	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
582744000627	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
582744000628	FAD binding site [chemical binding]; other site
582744000629	Protein of unknown function (DUF494); Region: DUF494; cl01103
582744000630	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
582744000631	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
582744000632	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
582744000633	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
582744000634	active site
582744000635	catalytic residues [active]
582744000636	metal binding site [ion binding]; metal-binding site
582744000637	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
582744000638	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
582744000639	putative active site [active]
582744000640	substrate binding site [chemical binding]; other site
582744000641	putative cosubstrate binding site; other site
582744000642	catalytic site [active]
582744000643	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
582744000644	substrate binding site [chemical binding]; other site
582744000645	Peptidase family M48; Region: Peptidase_M48; cl12018
582744000646	16S rRNA methyltransferase B; Provisional; Region: PRK10901
582744000647	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
582744000648	putative RNA binding site [nucleotide binding]; other site
582744000649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744000650	S-adenosylmethionine binding site [chemical binding]; other site
582744000651	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
582744000652	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
582744000653	dimerization interface [polypeptide binding]; other site
582744000654	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744000655	dimer interface [polypeptide binding]; other site
582744000656	phosphorylation site [posttranslational modification]
582744000657	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744000658	ATP binding site [chemical binding]; other site
582744000659	Mg2+ binding site [ion binding]; other site
582744000660	G-X-G motif; other site
582744000661	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582744000662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744000663	active site
582744000664	phosphorylation site [posttranslational modification]
582744000665	intermolecular recognition site; other site
582744000666	dimerization interface [polypeptide binding]; other site
582744000667	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744000668	TfoX N-terminal domain; Region: TfoX_N; cl01167
582744000669	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
582744000670	putative phosphate binding site [ion binding]; other site
582744000671	putative catalytic site [active]
582744000672	active site
582744000673	metal binding site A [ion binding]; metal-binding site
582744000674	DNA binding site [nucleotide binding]
582744000675	putative AP binding site [nucleotide binding]; other site
582744000676	putative metal binding site B [ion binding]; other site
582744000677	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
582744000678	catalytic residues [active]
582744000679	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
582744000680	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
582744000681	active site
582744000682	Zn binding site [ion binding]; other site
582744000683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
582744000684	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
582744000685	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
582744000686	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
582744000687	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
582744000688	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
582744000689	dimerization domain swap beta strand [polypeptide binding]; other site
582744000690	regulatory protein interface [polypeptide binding]; other site
582744000691	active site
582744000692	regulatory phosphorylation site [posttranslational modification]; other site
582744000693	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
582744000694	active pocket/dimerization site; other site
582744000695	active site
582744000696	phosphorylation site [posttranslational modification]
582744000697	P-loop ATPase protein family; Region: ATP_bind_2; cl10035
582744000698	HPr kinase/phosphorylase; Provisional; Region: PRK05428
582744000699	DRTGG domain; Region: DRTGG; cl12147
582744000700	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
582744000701	Hpr binding site; other site
582744000702	active site
582744000703	homohexamer subunit interaction site [polypeptide binding]; other site
582744000704	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
582744000705	30S subunit binding site; other site
582744000706	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
582744000707	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
582744000708	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
582744000709	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
582744000710	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
582744000711	Walker A/P-loop; other site
582744000712	ATP binding site [chemical binding]; other site
582744000713	Q-loop/lid; other site
582744000714	ABC transporter signature motif; other site
582744000715	Walker B; other site
582744000716	D-loop; other site
582744000717	H-loop/switch region; other site
582744000718	OstA-like protein; Region: OstA; cl00844
582744000719	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
582744000720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
582744000721	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744000722	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
582744000723	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014
582744000724	putative active site [active]
582744000725	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
582744000726	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
582744000727	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
582744000728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744000729	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
582744000730	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
582744000731	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
582744000732	Outer membrane protein (OmpH-like); Region: OmpH; cl08146
582744000733	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420
582744000734	trimer interface [polypeptide binding]; other site
582744000735	dimer interface [polypeptide binding]; other site
582744000736	putative active site [active]
582744000737	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
582744000738	Peptidase family M48; Region: Peptidase_M48; cl12018
582744000739	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744000740	TPR motif; other site
582744000741	binding surface
582744000742	Predicted secreted protein [Function unknown]; Region: COG5501; cl02313
582744000743	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
582744000744	peroxiredoxin; Region: AhpC; TIGR03137
582744000745	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015
582744000746	dimer interface [polypeptide binding]; other site
582744000747	decamer (pentamer of dimers) interface [polypeptide binding]; other site
582744000748	catalytic triad [active]
582744000749	peroxidatic and resolving cysteines [active]
582744000750	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
582744000751	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974
582744000752	catalytic residue [active]
582744000753	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
582744000754	catalytic residues [active]
582744000755	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744000756	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744000757	Domain of unknown function DUF20; Region: UPF0118; cl00465
582744000758	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
582744000759	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
582744000760	dimerization interface [polypeptide binding]; other site
582744000761	putative ATP binding site [chemical binding]; other site
582744000762	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
582744000763	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
582744000764	16S rRNA methyltransferase B; Provisional; Region: PRK14902
582744000765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744000766	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
582744000767	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
582744000768	EamA-like transporter family; Region: EamA; cl01037
582744000769	EamA-like transporter family; Region: EamA; cl01037
582744000770	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
582744000771	amidase catalytic site [active]
582744000772	Zn binding residues [ion binding]; other site
582744000773	substrate binding site [chemical binding]; other site
582744000774	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
582744000775	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
582744000776	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582744000777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744000778	active site
582744000779	phosphorylation site [posttranslational modification]
582744000780	intermolecular recognition site; other site
582744000781	dimerization interface [polypeptide binding]; other site
582744000782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744000783	Walker A motif; other site
582744000784	ATP binding site [chemical binding]; other site
582744000785	Walker B motif; other site
582744000786	arginine finger; other site
582744000787	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744000788	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582744000789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744000790	dimer interface [polypeptide binding]; other site
582744000791	phosphorylation site [posttranslational modification]
582744000792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744000793	ATP binding site [chemical binding]; other site
582744000794	Mg2+ binding site [ion binding]; other site
582744000795	G-X-G motif; other site
582744000796	RNA polymerase factor sigma-70; Validated; Region: PRK09047
582744000797	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
582744000798	DNA binding residues [nucleotide binding]
582744000799	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
582744000800	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
582744000801	RDD family; Region: RDD; cl00746
582744000802	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
582744000803	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
582744000804	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
582744000805	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
582744000806	multifunctional aminopeptidase A; Provisional; Region: PRK00913
582744000807	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
582744000808	interface (dimer of trimers) [polypeptide binding]; other site
582744000809	Substrate-binding/catalytic site; other site
582744000810	Zn-binding sites [ion binding]; other site
582744000811	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106
582744000812	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848
582744000813	lipoyl attachment site [posttranslational modification]; other site
582744000814	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
582744000815	Beta-lactamase; Region: Beta-lactamase; cl01009
582744000816	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
582744000817	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
582744000818	active site
582744000819	interdomain interaction site; other site
582744000820	putative metal-binding site [ion binding]; other site
582744000821	nucleotide binding site [chemical binding]; other site
582744000822	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
582744000823	domain I; other site
582744000824	DNA binding groove [nucleotide binding]
582744000825	phosphate binding site [ion binding]; other site
582744000826	domain II; other site
582744000827	domain III; other site
582744000828	nucleotide binding site [chemical binding]; other site
582744000829	catalytic site [active]
582744000830	domain IV; other site
582744000831	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
582744000832	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
582744000833	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_II; cd01993
582744000834	Ligand Binding Site [chemical binding]; other site
582744000835	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582744000836	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
582744000837	NADP binding site [chemical binding]; other site
582744000838	substrate binding pocket [chemical binding]; other site
582744000839	active site
582744000840	Uncharacterized conserved protein [Function unknown]; Region: COG1565
582744000841	Uncharacterized ACR, COG1565; Region: DUF185; pfam02636
582744000842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744000843	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
582744000844	G1 box; other site
582744000845	GTP/Mg2+ binding site [chemical binding]; other site
582744000846	Switch I region; other site
582744000847	G2 box; other site
582744000848	G3 box; other site
582744000849	Switch II region; other site
582744000850	G4 box; other site
582744000851	G5 box; other site
582744000852	Cytochrome c; Region: Cytochrom_C; cl11414
582744000853	Cytochrome c; Region: Cytochrom_C; cl11414
582744000854	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
582744000855	ResB-like family; Region: ResB; pfam05140
582744000856	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
582744000857	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582744000858	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744000859	ATP binding site [chemical binding]; other site
582744000860	Mg2+ binding site [ion binding]; other site
582744000861	G-X-G motif; other site
582744000862	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
582744000863	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
582744000864	Walker A/P-loop; other site
582744000865	ATP binding site [chemical binding]; other site
582744000866	Q-loop/lid; other site
582744000867	ABC transporter signature motif; other site
582744000868	Walker B; other site
582744000869	D-loop; other site
582744000870	H-loop/switch region; other site
582744000871	Domain of unknown function DUF140; Region: DUF140; cl00510
582744000872	mce related protein; Region: MCE; cl03606
582744000873	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074
582744000874	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
582744000875	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
582744000876	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
582744000877	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263
582744000878	Walker A/P-loop; other site
582744000879	ATP binding site [chemical binding]; other site
582744000880	Q-loop/lid; other site
582744000881	ABC transporter signature motif; other site
582744000882	Walker B; other site
582744000883	D-loop; other site
582744000884	H-loop/switch region; other site
582744000885	ABC-2 type transporter; Region: ABC2_membrane; cl11417
582744000886	BolA-like protein; Region: BolA; cl00386
582744000887	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
582744000888	putative GSH binding site [chemical binding]; other site
582744000889	catalytic residues [active]
582744000890	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
582744000891	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
582744000892	hinge; other site
582744000893	active site
582744000894	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744000895	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
582744000896	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
582744000897	NAD binding site [chemical binding]; other site
582744000898	dimerization interface [polypeptide binding]; other site
582744000899	product binding site; other site
582744000900	substrate binding site [chemical binding]; other site
582744000901	zinc binding site [ion binding]; other site
582744000902	catalytic residues [active]
582744000903	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
582744000904	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744000905	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744000906	homodimer interface [polypeptide binding]; other site
582744000907	catalytic residue [active]
582744000908	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
582744000909	active site
582744000910	dimer interface [polypeptide binding]; other site
582744000911	magnesium binding site [ion binding]; other site
582744000912	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
582744000913	putative active site pocket [active]
582744000914	4-fold oligomerization interface [polypeptide binding]; other site
582744000915	metal binding residues [ion binding]; metal-binding site
582744000916	3-fold/trimer interface [polypeptide binding]; other site
582744000917	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
582744000918	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
582744000919	putative active site [active]
582744000920	oxyanion strand; other site
582744000921	catalytic triad [active]
582744000922	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
582744000923	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
582744000924	catalytic residues [active]
582744000925	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
582744000926	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
582744000927	substrate binding site [chemical binding]; other site
582744000928	glutamase interaction surface [polypeptide binding]; other site
582744000929	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
582744000930	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
582744000931	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
582744000932	nucleotide binding site/active site [active]
582744000933	HIT family signature motif; other site
582744000934	catalytic residue [active]
582744000935	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
582744000936	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
582744000937	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
582744000938	serine endoprotease; Provisional; Region: PRK10898
582744000939	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
582744000940	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
582744000941	protein binding site [polypeptide binding]; other site
582744000942	Uncharacterized conserved protein [Function unknown]; Region: COG0327
582744000943	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309
582744000944	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
582744000945	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
582744000946	[2Fe-2S] cluster binding site [ion binding]; other site
582744000947	cytochrome b; Provisional; Region: CYTB; MTH00145
582744000948	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284
582744000949	Qi binding site; other site
582744000950	intrachain domain interface; other site
582744000951	interchain domain interface [polypeptide binding]; other site
582744000952	heme bH binding site [chemical binding]; other site
582744000953	heme bL binding site [chemical binding]; other site
582744000954	Qo binding site; other site
582744000955	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cd00290
582744000956	interchain domain interface [polypeptide binding]; other site
582744000957	intrachain domain interface; other site
582744000958	Qi binding site; other site
582744000959	Qo binding site; other site
582744000960	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
582744000961	stringent starvation protein A; Provisional; Region: sspA; PRK09481
582744000962	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
582744000963	C-terminal domain interface [polypeptide binding]; other site
582744000964	putative GSH binding site (G-site) [chemical binding]; other site
582744000965	dimer interface [polypeptide binding]; other site
582744000966	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186
582744000967	dimer interface [polypeptide binding]; other site
582744000968	N-terminal domain interface [polypeptide binding]; other site
582744000969	Stringent starvation protein B; Region: SspB; cl01120
582744000970	elongation factor Tu; Reviewed; Region: PRK00049
582744000971	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
582744000972	G1 box; other site
582744000973	GEF interaction site [polypeptide binding]; other site
582744000974	GTP/Mg2+ binding site [chemical binding]; other site
582744000975	Switch I region; other site
582744000976	G2 box; other site
582744000977	G3 box; other site
582744000978	Switch II region; other site
582744000979	G4 box; other site
582744000980	G5 box; other site
582744000981	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
582744000982	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
582744000983	Antibiotic Binding Site [chemical binding]; other site
582744000984	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
582744000985	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
582744000986	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
582744000987	putative homodimer interface [polypeptide binding]; other site
582744000988	KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739
582744000989	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
582744000990	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
582744000991	23S rRNA interface [nucleotide binding]; other site
582744000992	L7/L12 interface [polypeptide binding]; other site
582744000993	putative thiostrepton binding site; other site
582744000994	L25 interface [polypeptide binding]; other site
582744000995	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
582744000996	mRNA/rRNA interface [nucleotide binding]; other site
582744000997	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
582744000998	23S rRNA interface [nucleotide binding]; other site
582744000999	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
582744001000	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
582744001001	core dimer interface [polypeptide binding]; other site
582744001002	peripheral dimer interface [polypeptide binding]; other site
582744001003	L10 interface [polypeptide binding]; other site
582744001004	L11 interface [polypeptide binding]; other site
582744001005	putative EF-Tu interaction site [polypeptide binding]; other site
582744001006	putative EF-G interaction site [polypeptide binding]; other site
582744001007	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
582744001008	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
582744001009	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
582744001010	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
582744001011	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
582744001012	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
582744001013	RPB11 interaction site [polypeptide binding]; other site
582744001014	RPB12 interaction site [polypeptide binding]; other site
582744001015	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
582744001016	RPB3 interaction site [polypeptide binding]; other site
582744001017	RPB1 interaction site [polypeptide binding]; other site
582744001018	RPB11 interaction site [polypeptide binding]; other site
582744001019	RPB10 interaction site [polypeptide binding]; other site
582744001020	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
582744001021	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
582744001022	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
582744001023	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
582744001024	DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388
582744001025	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
582744001026	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
582744001027	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
582744001028	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
582744001029	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
582744001030	DNA binding site [nucleotide binding]
582744001031	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
582744001032	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
582744001033	S17 interaction site [polypeptide binding]; other site
582744001034	S8 interaction site; other site
582744001035	16S rRNA interaction site [nucleotide binding]; other site
582744001036	streptomycin interaction site [chemical binding]; other site
582744001037	23S rRNA interaction site [nucleotide binding]; other site
582744001038	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
582744001039	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
582744001040	elongation factor G; Reviewed; Region: PRK00007
582744001041	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
582744001042	G1 box; other site
582744001043	putative GEF interaction site [polypeptide binding]; other site
582744001044	GTP/Mg2+ binding site [chemical binding]; other site
582744001045	Switch I region; other site
582744001046	G2 box; other site
582744001047	G3 box; other site
582744001048	Switch II region; other site
582744001049	G4 box; other site
582744001050	G5 box; other site
582744001051	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
582744001052	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
582744001053	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
582744001054	elongation factor Tu; Reviewed; Region: PRK00049
582744001055	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
582744001056	G1 box; other site
582744001057	GEF interaction site [polypeptide binding]; other site
582744001058	GTP/Mg2+ binding site [chemical binding]; other site
582744001059	Switch I region; other site
582744001060	G2 box; other site
582744001061	G3 box; other site
582744001062	Switch II region; other site
582744001063	G4 box; other site
582744001064	G5 box; other site
582744001065	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
582744001066	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
582744001067	Antibiotic Binding Site [chemical binding]; other site
582744001068	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
582744001069	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
582744001070	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
582744001071	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
582744001072	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
582744001073	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
582744001074	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
582744001075	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
582744001076	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
582744001077	putative translocon binding site; other site
582744001078	protein-rRNA interface [nucleotide binding]; other site
582744001079	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
582744001080	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
582744001081	G-X-X-G motif; other site
582744001082	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
582744001083	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
582744001084	23S rRNA interface [nucleotide binding]; other site
582744001085	5S rRNA interface [nucleotide binding]; other site
582744001086	putative antibiotic binding site [chemical binding]; other site
582744001087	L25 interface [polypeptide binding]; other site
582744001088	L27 interface [polypeptide binding]; other site
582744001089	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
582744001090	23S rRNA interface [nucleotide binding]; other site
582744001091	putative translocon interaction site; other site
582744001092	signal recognition particle (SRP54) interaction site; other site
582744001093	L23 interface [polypeptide binding]; other site
582744001094	trigger factor interaction site; other site
582744001095	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
582744001096	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
582744001097	KOW motif; Region: KOW; cl00354
582744001098	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
582744001099	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
582744001100	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
582744001101	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
582744001102	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
582744001103	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
582744001104	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
582744001105	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
582744001106	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
582744001107	5S rRNA interface [nucleotide binding]; other site
582744001108	L27 interface [polypeptide binding]; other site
582744001109	23S rRNA interface [nucleotide binding]; other site
582744001110	L5 interface [polypeptide binding]; other site
582744001111	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
582744001112	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
582744001113	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
582744001114	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
582744001115	23S rRNA binding site [nucleotide binding]; other site
582744001116	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
582744001117	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
582744001118	SecY translocase; Region: SecY; pfam00344
582744001119	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
582744001120	rRNA binding site [nucleotide binding]; other site
582744001121	predicted 30S ribosome binding site; other site
582744001122	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
582744001123	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
582744001124	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
582744001125	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
582744001126	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
582744001127	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
582744001128	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582744001129	RNA binding surface [nucleotide binding]; other site
582744001130	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
582744001131	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
582744001132	alphaNTD homodimer interface [polypeptide binding]; other site
582744001133	alphaNTD - beta interaction site [polypeptide binding]; other site
582744001134	alphaNTD - beta' interaction site [polypeptide binding]; other site
582744001135	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
582744001136	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
582744001137	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582744001138	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
582744001139	MgtE intracellular N domain; Region: MgtE_N; cl15244
582744001140	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
582744001141	Divalent cation transporter; Region: MgtE; cl00786
582744001142	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
582744001143	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582744001144	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
582744001145	Di-iron ligands [ion binding]; other site
582744001146	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
582744001147	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
582744001148	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
582744001149	trimer interface [polypeptide binding]; other site
582744001150	active site
582744001151	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
582744001152	Flavoprotein; Region: Flavoprotein; cl08021
582744001153	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
582744001154	Peroxin-3; Region: Peroxin-3; pfam04882
582744001155	hypothetical protein; Reviewed; Region: PRK00024
582744001156	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
582744001157	MPN+ (JAMM) motif; other site
582744001158	Zinc-binding site [ion binding]; other site
582744001159	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
582744001160	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
582744001161	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
582744001162	Uncharacterized conserved protein [Function unknown]; Region: COG2308
582744001163	Domain of unknown function (DUF404); Region: DUF404; pfam04169
582744001164	Domain of unknown function (DUF407); Region: DUF407; pfam04174
582744001165	Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980
582744001166	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
582744001167	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
582744001168	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
582744001169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
582744001170	NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754
582744001171	[4Fe-4S] binding site [ion binding]; other site
582744001172	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
582744001173	molybdopterin cofactor binding site; other site
582744001174	NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
582744001175	molybdopterin cofactor binding site; other site
582744001176	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
582744001177	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
582744001178	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
582744001179	[2Fe-2S] cluster binding site [ion binding]; other site
582744001180	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
582744001181	Active site [active]
582744001182	Catalytic domain of Protein Kinases; Region: PKc; cd00180
582744001183	active site
582744001184	ATP binding site [chemical binding]; other site
582744001185	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
582744001186	substrate binding site [chemical binding]; other site
582744001187	activation loop (A-loop); other site
582744001188	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
582744001189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744001190	putative substrate translocation pore; other site
582744001191	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
582744001192	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744001193	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
582744001194	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582744001195	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
582744001196	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744001197	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
582744001198	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
582744001199	Walker A/P-loop; other site
582744001200	ATP binding site [chemical binding]; other site
582744001201	Q-loop/lid; other site
582744001202	ABC transporter signature motif; other site
582744001203	Walker B; other site
582744001204	D-loop; other site
582744001205	H-loop/switch region; other site
582744001206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744001207	dimer interface [polypeptide binding]; other site
582744001208	conserved gate region; other site
582744001209	putative PBP binding loops; other site
582744001210	ABC-ATPase subunit interface; other site
582744001211	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582744001212	Nitrate and nitrite sensing; Region: NIT; pfam08376
582744001213	ANTAR domain; Region: ANTAR; pfam03861
582744001214	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
582744001215	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
582744001216	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
582744001217	Walker A/P-loop; other site
582744001218	ATP binding site [chemical binding]; other site
582744001219	Q-loop/lid; other site
582744001220	ABC transporter signature motif; other site
582744001221	Walker B; other site
582744001222	D-loop; other site
582744001223	H-loop/switch region; other site
582744001224	similar to hypothetical protein
582744001225	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
582744001226	Carbon starvation protein CstA; Region: CstA; cl00856
582744001227	Protein of unknown function (DUF466); Region: DUF466; cl01082
582744001228	Protein of unknown function (DUF2805); Region: DUF2805; cl11923
582744001229	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
582744001230	PAS fold; Region: PAS_4; pfam08448
582744001231	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744001232	putative active site [active]
582744001233	heme pocket [chemical binding]; other site
582744001234	PAS fold; Region: PAS_4; pfam08448
582744001235	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744001236	metal binding site [ion binding]; metal-binding site
582744001237	active site
582744001238	I-site; other site
582744001239	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744001240	Dehydratase family; Region: ILVD_EDD; cl00340
582744001241	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
582744001242	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
582744001243	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
582744001244	active site
582744001245	phosphate binding residues; other site
582744001246	catalytic residues [active]
582744001247	Cytochrome c; Region: Cytochrom_C; cl11414
582744001248	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
582744001249	homotrimer interaction site [polypeptide binding]; other site
582744001250	putative active site [active]
582744001251	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
582744001252	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
582744001253	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
582744001254	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
582744001255	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
582744001256	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
582744001257	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
582744001258	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744001259	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
582744001260	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
582744001261	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
582744001262	purine monophosphate binding site [chemical binding]; other site
582744001263	dimer interface [polypeptide binding]; other site
582744001264	putative catalytic residues [active]
582744001265	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
582744001266	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
582744001267	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744001268	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
582744001269	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
582744001270	FMN binding site [chemical binding]; other site
582744001271	active site
582744001272	catalytic residues [active]
582744001273	substrate binding site [chemical binding]; other site
582744001274	metabolite-proton symporter; Region: 2A0106; TIGR00883
582744001275	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
582744001276	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
582744001277	putative MPT binding site; other site
582744001278	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
582744001279	DNA polymerase I; Provisional; Region: PRK05755
582744001280	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
582744001281	active site
582744001282	metal binding site 1 [ion binding]; metal-binding site
582744001283	putative 5' ssDNA interaction site; other site
582744001284	metal binding site 3; metal-binding site
582744001285	metal binding site 2 [ion binding]; metal-binding site
582744001286	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
582744001287	putative DNA binding site [nucleotide binding]; other site
582744001288	putative metal binding site [ion binding]; other site
582744001289	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
582744001290	active site
582744001291	catalytic site [active]
582744001292	substrate binding site [chemical binding]; other site
582744001293	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
582744001294	active site
582744001295	DNA binding site [nucleotide binding]
582744001296	catalytic site [active]
582744001297	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
582744001298	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
582744001299	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
582744001300	Phosphotransferase enzyme family; Region: APH; pfam01636
582744001301	putative active site [active]
582744001302	putative substrate binding site [chemical binding]; other site
582744001303	ATP binding site [chemical binding]; other site
582744001304	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
582744001305	UvrD/REP helicase; Region: UvrD-helicase; cl14126
582744001306	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582744001307	ligand binding site [chemical binding]; other site
582744001308	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
582744001309	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744001310	metal binding site [ion binding]; metal-binding site
582744001311	active site
582744001312	I-site; other site
582744001313	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
582744001314	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744001315	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744001316	dimer interface [polypeptide binding]; other site
582744001317	phosphorylation site [posttranslational modification]
582744001318	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744001319	ATP binding site [chemical binding]; other site
582744001320	Mg2+ binding site [ion binding]; other site
582744001321	G-X-G motif; other site
582744001322	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
582744001323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744001324	active site
582744001325	phosphorylation site [posttranslational modification]
582744001326	intermolecular recognition site; other site
582744001327	dimerization interface [polypeptide binding]; other site
582744001328	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
582744001329	DNA binding site [nucleotide binding]
582744001330	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
582744001331	Outer membrane efflux protein; Region: OEP; pfam02321
582744001332	Outer membrane efflux protein; Region: OEP; pfam02321
582744001333	Multicopper oxidase; Region: Cu-oxidase; cl14658
582744001334	Multicopper oxidase; Region: Cu-oxidase; cl14658
582744001335	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
582744001336	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
582744001337	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
582744001338	ring oligomerisation interface [polypeptide binding]; other site
582744001339	ATP/Mg binding site [chemical binding]; other site
582744001340	stacking interactions; other site
582744001341	hinge regions; other site
582744001342	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
582744001343	oligomerisation interface [polypeptide binding]; other site
582744001344	mobile loop; other site
582744001345	roof hairpin; other site
582744001346	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744001347	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX.  The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
582744001348	putative deacylase active site [active]
582744001349	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
582744001350	DEAD_2; Region: DEAD_2; cl14887
582744001351	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
582744001352	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
582744001353	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659
582744001354	DNA binding site [nucleotide binding]
582744001355	active site
582744001356	Int/Topo IB signature motif; other site
582744001357	catalytic residues [active]
582744001358	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582744001359	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582744001360	DNA-binding site [nucleotide binding]; DNA binding site
582744001361	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744001362	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744001363	homodimer interface [polypeptide binding]; other site
582744001364	catalytic residue [active]
582744001365	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
582744001366	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
582744001367	Response regulator receiver domain; Region: Response_reg; pfam00072
582744001368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744001369	active site
582744001370	phosphorylation site [posttranslational modification]
582744001371	intermolecular recognition site; other site
582744001372	dimerization interface [polypeptide binding]; other site
582744001373	PAS domain S-box; Region: sensory_box; TIGR00229
582744001374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744001375	putative active site [active]
582744001376	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744001377	metal binding site [ion binding]; metal-binding site
582744001378	active site
582744001379	I-site; other site
582744001380	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744001381	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
582744001382	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744001383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582744001384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744001385	dimer interface [polypeptide binding]; other site
582744001386	phosphorylation site [posttranslational modification]
582744001387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744001388	ATP binding site [chemical binding]; other site
582744001389	Mg2+ binding site [ion binding]; other site
582744001390	G-X-G motif; other site
582744001391	Secretin and TonB N terminus short domain; Region: STN; pfam07660
582744001392	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744001393	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744001394	N-terminal plug; other site
582744001395	ligand-binding site [chemical binding]; other site
582744001396	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
582744001397	FecR protein; Region: FecR; pfam04773
582744001398	RNA polymerase sigma factor; Reviewed; Region: PRK12523
582744001399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744001400	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744001401	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582744001402	RNA polymerase sigma factor; Provisional; Region: PRK12528
582744001403	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744001404	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744001405	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
582744001406	FecR protein; Region: FecR; pfam04773
582744001407	Secretin and TonB N terminus short domain; Region: STN; pfam07660
582744001408	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
582744001409	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744001410	N-terminal plug; other site
582744001411	ligand-binding site [chemical binding]; other site
582744001412	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582744001413	Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670
582744001414	macrolide transporter subunit MacA; Provisional; Region: PRK11578
582744001415	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
582744001416	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
582744001417	Walker A/P-loop; other site
582744001418	ATP binding site [chemical binding]; other site
582744001419	Q-loop/lid; other site
582744001420	ABC transporter signature motif; other site
582744001421	Walker B; other site
582744001422	D-loop; other site
582744001423	H-loop/switch region; other site
582744001424	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582744001425	FtsX-like permease family; Region: FtsX; pfam02687
582744001426	NodT family; Region: outer_NodT; TIGR01845
582744001427	Outer membrane efflux protein; Region: OEP; pfam02321
582744001428	Outer membrane efflux protein; Region: OEP; pfam02321
582744001429	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
582744001430	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
582744001431	inhibitor-cofactor binding pocket; inhibition site
582744001432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744001433	catalytic residue [active]
582744001434	Beta-lactamase; Region: Beta-lactamase; cl01009
582744001435	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
582744001436	OsmC-like protein; Region: OsmC; cl00767
582744001437	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
582744001438	active site
582744001439	metal binding site [ion binding]; metal-binding site
582744001440	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
582744001441	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744001442	N-terminal plug; other site
582744001443	ligand-binding site [chemical binding]; other site
582744001444	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820
582744001445	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
582744001446	diiron binding motif [ion binding]; other site
582744001447	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
582744001448	C-terminal peptidase (prc); Region: prc; TIGR00225
582744001449	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
582744001450	protein binding site [polypeptide binding]; other site
582744001451	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
582744001452	Catalytic dyad [active]
582744001453	Rdx family; Region: Rdx; cl01407
582744001454	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744001455	NlpC/P60 family; Region: NLPC_P60; cl11438
582744001456	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
582744001457	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
582744001458	Uncharacterized conserved protein [Function unknown]; Region: COG2308
582744001459	Domain of unknown function (DUF404); Region: DUF404; pfam04169
582744001460	Domain of unknown function (DUF407); Region: DUF407; pfam04174
582744001461	Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980
582744001462	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
582744001463	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
582744001464	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
582744001465	Peptidase family U32; Region: Peptidase_U32; cl03113
582744001466	Collagenase; Region: DUF3656; pfam12392
582744001467	cell division protein MraZ; Reviewed; Region: PRK00326
582744001468	MraZ protein; Region: MraZ; pfam02381
582744001469	MraZ protein; Region: MraZ; pfam02381
582744001470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744001471	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
582744001472	Septum formation initiator; Region: DivIC; cl11433
582744001473	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
582744001474	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
582744001475	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
582744001476	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
582744001477	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582744001478	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582744001479	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582744001480	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582744001481	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
582744001482	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582744001483	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582744001484	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
582744001485	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
582744001486	Mg++ binding site [ion binding]; other site
582744001487	putative catalytic motif [active]
582744001488	putative substrate binding site [chemical binding]; other site
582744001489	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
582744001490	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582744001491	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
582744001492	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
582744001493	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
582744001494	active site
582744001495	homodimer interface [polypeptide binding]; other site
582744001496	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
582744001497	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582744001498	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582744001499	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582744001500	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
582744001501	FAD binding domain; Region: FAD_binding_4; pfam01565
582744001502	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
582744001503	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
582744001504	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
582744001505	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744001506	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
582744001507	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
582744001508	Cell division protein FtsQ; Region: FtsQ; pfam03799
582744001509	cell division protein FtsA; Region: ftsA; TIGR01174
582744001510	Cell division protein FtsA; Region: FtsA; cl11496
582744001511	Cell division protein FtsA; Region: FtsA; cl11496
582744001512	cell division protein FtsZ; Validated; Region: PRK09330
582744001513	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
582744001514	nucleotide binding site [chemical binding]; other site
582744001515	SulA interaction site; other site
582744001516	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
582744001517	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
582744001518	lytic murein transglycosylase; Provisional; Region: PRK11619
582744001519	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
582744001520	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582744001521	catalytic residue [active]
582744001522	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
582744001523	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
582744001524	putative NAD(P) binding site [chemical binding]; other site
582744001525	active site
582744001526	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
582744001527	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
582744001528	active site
582744001529	NTP binding site [chemical binding]; other site
582744001530	metal binding triad [ion binding]; metal-binding site
582744001531	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
582744001532	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744001533	division inhibitor protein; Provisional; Region: slmA; PRK09480
582744001534	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744001535	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
582744001536	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744001537	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250
582744001538	feedback inhibition sensing region; other site
582744001539	homohexameric interface [polypeptide binding]; other site
582744001540	nucleotide binding site [chemical binding]; other site
582744001541	N-acetyl-L-glutamate binding site [chemical binding]; other site
582744001542	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
582744001543	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
582744001544	Potassium binding sites [ion binding]; other site
582744001545	Cesium cation binding sites [ion binding]; other site
582744001546	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
582744001547	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
582744001548	putative dimer interface [polypeptide binding]; other site
582744001549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582744001550	non-specific DNA binding site [nucleotide binding]; other site
582744001551	salt bridge; other site
582744001552	sequence-specific DNA binding site [nucleotide binding]; other site
582744001553	N-acetylglutamate synthase; Validated; Region: PRK05279
582744001554	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237
582744001555	putative feedback inhibition sensing region; other site
582744001556	putative nucleotide binding site [chemical binding]; other site
582744001557	putative substrate binding site [chemical binding]; other site
582744001558	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582744001559	Coenzyme A binding pocket [chemical binding]; other site
582744001560	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
582744001561	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
582744001562	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
582744001563	putative catalytic residue [active]
582744001564	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744001565	metal binding site [ion binding]; metal-binding site
582744001566	active site
582744001567	I-site; other site
582744001568	transketolase; Reviewed; Region: PRK12753
582744001569	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
582744001570	TPP-binding site [chemical binding]; other site
582744001571	dimer interface [polypeptide binding]; other site
582744001572	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582744001573	PYR/PP interface [polypeptide binding]; other site
582744001574	dimer interface [polypeptide binding]; other site
582744001575	TPP binding site [chemical binding]; other site
582744001576	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582744001577	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744001578	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
582744001579	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
582744001580	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
582744001581	substrate binding site [chemical binding]; other site
582744001582	hinge regions; other site
582744001583	ADP binding site [chemical binding]; other site
582744001584	catalytic site [active]
582744001585	pyruvate kinase; Provisional; Region: PRK05826
582744001586	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
582744001587	domain interfaces; other site
582744001588	active site
582744001589	hypothetical protein; Provisional; Region: PRK08185
582744001590	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
582744001591	intersubunit interface [polypeptide binding]; other site
582744001592	active site
582744001593	zinc binding site [ion binding]; other site
582744001594	Na+ binding site [ion binding]; other site
582744001595	Phosphate-starvation-inducible E; Region: PsiE; cl01264
582744001596	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
582744001597	ATP binding site [chemical binding]; other site
582744001598	active site
582744001599	substrate binding site [chemical binding]; other site
582744001600	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
582744001601	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
582744001602	active site clefts [active]
582744001603	zinc binding site [ion binding]; other site
582744001604	dimer interface [polypeptide binding]; other site
582744001605	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
582744001606	dimer interface [polypeptide binding]; other site
582744001607	substrate binding site [chemical binding]; other site
582744001608	metal binding sites [ion binding]; metal-binding site
582744001609	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
582744001610	ABC-2 type transporter; Region: ABC2_membrane; cl11417
582744001611	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
582744001612	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
582744001613	Walker A/P-loop; other site
582744001614	ATP binding site [chemical binding]; other site
582744001615	Q-loop/lid; other site
582744001616	ABC transporter signature motif; other site
582744001617	Walker B; other site
582744001618	D-loop; other site
582744001619	H-loop/switch region; other site
582744001620	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
582744001621	Protein of unknown function (DUF721); Region: DUF721; cl02324
582744001622	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
582744001623	Peptidase family M23; Region: Peptidase_M23; pfam01551
582744001624	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
582744001625	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744001626	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
582744001627	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744001628	nucleotide binding region [chemical binding]; other site
582744001629	ATP-binding site [chemical binding]; other site
582744001630	hypothetical protein; Provisional; Region: PRK10396
582744001631	SEC-C motif; Region: SEC-C; cl12132
582744001632	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
582744001633	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
582744001634	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152
582744001635	heterotetramer interface [polypeptide binding]; other site
582744001636	active site pocket [active]
582744001637	cleavage site
582744001638	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
582744001639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744001640	Walker A motif; other site
582744001641	ATP binding site [chemical binding]; other site
582744001642	Walker B motif; other site
582744001643	hypothetical protein; Provisional; Region: PRK08999
582744001644	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
582744001645	active site
582744001646	8-oxo-dGMP binding site [chemical binding]; other site
582744001647	nudix motif; other site
582744001648	metal binding site [ion binding]; metal-binding site
582744001649	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
582744001650	thiamine phosphate binding site [chemical binding]; other site
582744001651	active site
582744001652	pyrophosphate binding site [ion binding]; other site
582744001653	Protein of unknown function (DUF461); Region: DUF461; cl01071
582744001654	Protein of unknown function (DUF1342); Region: DUF1342; cl01892
582744001655	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
582744001656	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
582744001657	CoA-binding site [chemical binding]; other site
582744001658	ATP-binding [chemical binding]; other site
582744001659	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
582744001660	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
582744001661	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
582744001662	octaprenyl diphosphate synthase; Provisional; Region: PRK10888
582744001663	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
582744001664	substrate binding pocket [chemical binding]; other site
582744001665	chain length determination region; other site
582744001666	substrate-Mg2+ binding site; other site
582744001667	catalytic residues [active]
582744001668	aspartate-rich region 1; other site
582744001669	active site lid residues [active]
582744001670	aspartate-rich region 2; other site
582744001671	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
582744001672	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
582744001673	GTPase CgtA; Reviewed; Region: obgE; PRK12299
582744001674	GTP1/OBG; Region: GTP1_OBG; pfam01018
582744001675	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
582744001676	G1 box; other site
582744001677	GTP/Mg2+ binding site [chemical binding]; other site
582744001678	Switch I region; other site
582744001679	G2 box; other site
582744001680	G3 box; other site
582744001681	Switch II region; other site
582744001682	G4 box; other site
582744001683	G5 box; other site
582744001684	gamma-glutamyl kinase; Provisional; Region: PRK05429
582744001685	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
582744001686	nucleotide binding site [chemical binding]; other site
582744001687	homotetrameric interface [polypeptide binding]; other site
582744001688	putative phosphate binding site [ion binding]; other site
582744001689	putative allosteric binding site; other site
582744001690	PUA domain; Region: PUA; cl00607
582744001691	AIR carboxylase; Region: AIRC; cl00310
582744001692	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
582744001693	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744001694	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
582744001695	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
582744001696	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
582744001697	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
582744001698	active site
582744001699	Riboflavin kinase; Region: Flavokinase; pfam01687
582744001700	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
582744001701	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582744001702	active site
582744001703	HIGH motif; other site
582744001704	nucleotide binding site [chemical binding]; other site
582744001705	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
582744001706	active site
582744001707	KMSKS motif; other site
582744001708	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
582744001709	tRNA binding surface [nucleotide binding]; other site
582744001710	anticodon binding site; other site
582744001711	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
582744001712	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
582744001713	lipoprotein signal peptidase; Provisional; Region: PRK14787
582744001714	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
582744001715	Moco binding site; other site
582744001716	metal coordination site [ion binding]; other site
582744001717	SelR domain; Region: SelR; cl00369
582744001718	Protein of unknown function (DUF808); Region: DUF808; cl01002
582744001719	probable cinnamyl alcohol dehydrogenase; Region: PLN02586
582744001720	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
582744001721	putative NAD(P) binding site [chemical binding]; other site
582744001722	putative substrate binding site [chemical binding]; other site
582744001723	catalytic Zn binding site [ion binding]; other site
582744001724	structural Zn binding site [ion binding]; other site
582744001725	dimer interface [polypeptide binding]; other site
582744001726	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
582744001727	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
582744001728	tetramer interface [polypeptide binding]; other site
582744001729	heme binding pocket [chemical binding]; other site
582744001730	NADPH binding site [chemical binding]; other site
582744001731	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
582744001732	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
582744001733	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
582744001734	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
582744001735	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
582744001736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744001737	active site
582744001738	phosphorylation site [posttranslational modification]
582744001739	intermolecular recognition site; other site
582744001740	dimerization interface [polypeptide binding]; other site
582744001741	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744001742	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
582744001743	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744001744	phosphorylation site [posttranslational modification]
582744001745	dimer interface [polypeptide binding]; other site
582744001746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744001747	ATP binding site [chemical binding]; other site
582744001748	Mg2+ binding site [ion binding]; other site
582744001749	G-X-G motif; other site
582744001750	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
582744001751	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744001752	N-terminal plug; other site
582744001753	ligand-binding site [chemical binding]; other site
582744001754	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582744001755	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
582744001756	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
582744001757	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
582744001758	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
582744001759	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
582744001760	Zn2+ binding site [ion binding]; other site
582744001761	Mg2+ binding site [ion binding]; other site
582744001762	PAS fold; Region: PAS_4; pfam08448
582744001763	GAF domain; Region: GAF; cl00853
582744001764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744001765	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
582744001766	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744001767	metal binding site [ion binding]; metal-binding site
582744001768	active site
582744001769	I-site; other site
582744001770	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744001771	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
582744001772	Clp amino terminal domain; Region: Clp_N; pfam02861
582744001773	Clp amino terminal domain; Region: Clp_N; pfam02861
582744001774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744001775	Walker A motif; other site
582744001776	ATP binding site [chemical binding]; other site
582744001777	Walker B motif; other site
582744001778	arginine finger; other site
582744001779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744001780	Walker A motif; other site
582744001781	ATP binding site [chemical binding]; other site
582744001782	Walker B motif; other site
582744001783	arginine finger; other site
582744001784	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
582744001785	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
582744001786	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
582744001787	NADP binding site [chemical binding]; other site
582744001788	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744001789	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582744001790	Sel1 repeat; Region: Sel1; cl02723
582744001791	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
582744001792	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582744001793	catalytic residue [active]
582744001794	Uncharacterised protein family UPF0047; Region: UPF0047; cl00439
582744001795	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
582744001796	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
582744001797	putative active site [active]
582744001798	metal binding site [ion binding]; metal-binding site
582744001799	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582744001800	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814
582744001801	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
582744001802	Peptidase family M23; Region: Peptidase_M23; pfam01551
582744001803	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
582744001804	Sulfatase; Region: Sulfatase; cl10460
582744001805	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
582744001806	active site residue [active]
582744001807	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
582744001808	GSH binding site [chemical binding]; other site
582744001809	catalytic residues [active]
582744001810	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
582744001811	SecA binding site; other site
582744001812	Preprotein binding site; other site
582744001813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
582744001814	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
582744001815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744001816	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
582744001817	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
582744001818	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
582744001819	active site clefts [active]
582744001820	zinc binding site [ion binding]; other site
582744001821	dimer interface [polypeptide binding]; other site
582744001822	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
582744001823	Sulfate transporter family; Region: Sulfate_transp; cl00967
582744001824	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
582744001825	anti sigma factor interaction site; other site
582744001826	regulatory phosphorylation site [posttranslational modification]; other site
582744001827	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
582744001828	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
582744001829	biotin synthetase; Region: bioB; TIGR00433
582744001830	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744001831	FeS/SAM binding site; other site
582744001832	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
582744001833	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
582744001834	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582744001835	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744001836	catalytic residue [active]
582744001837	putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738
582744001838	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744001839	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
582744001840	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744001841	S-adenosylmethionine binding site [chemical binding]; other site
582744001842	Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797
582744001843	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744001844	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
582744001845	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
582744001846	active site
582744001847	(T/H)XGH motif; other site
582744001848	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
582744001849	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
582744001850	putative catalytic cysteine [active]
582744001851	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
582744001852	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
582744001853	Lipopolysaccharide-assembly; Region: LptE; cl01125
582744001854	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
582744001855	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
582744001856	HIGH motif; other site
582744001857	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
582744001858	active site
582744001859	KMSKS motif; other site
582744001860	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
582744001861	tRNA binding surface [nucleotide binding]; other site
582744001862	adenylate kinase; Reviewed; Region: adk; PRK00279
582744001863	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
582744001864	AMP-binding site [chemical binding]; other site
582744001865	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
582744001866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744001867	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
582744001868	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
582744001869	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
582744001870	SurA N-terminal domain; Region: SurA_N; pfam09312
582744001871	PPIC-type PPIASE domain; Region: Rotamase; cl08278
582744001872	PPIC-type PPIASE domain; Region: Rotamase; cl08278
582744001873	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
582744001874	OstA-like protein; Region: OstA; cl00844
582744001875	Organic solvent tolerance protein; Region: OstA_C; pfam04453
582744001876	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
582744001877	Phosphotransferase enzyme family; Region: APH; pfam01636
582744001878	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
582744001879	Substrate binding site [chemical binding]; other site
582744001880	metal binding site [ion binding]; metal-binding site
582744001881	proline aminopeptidase P II; Provisional; Region: PRK10879
582744001882	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
582744001883	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087
582744001884	active site
582744001885	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744001886	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
582744001887	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
582744001888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744001889	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
582744001890	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020
582744001891	dimerization domain [polypeptide binding]; other site
582744001892	dimer interface [polypeptide binding]; other site
582744001893	catalytic residues [active]
582744001894	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
582744001895	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744001896	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744001897	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
582744001898	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
582744001899	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
582744001900	Walker A motif; other site
582744001901	ATP binding site [chemical binding]; other site
582744001902	Walker B motif; other site
582744001903	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
582744001904	DNA-binding site [nucleotide binding]; DNA binding site
582744001905	RNA-binding motif; other site
582744001906	isocitrate dehydrogenase; Validated; Region: PRK07362
582744001907	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
582744001908	PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-...; Region: PseudoU_synth_RluE; cd02566
582744001909	probable active site [active]
582744001910	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
582744001911	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
582744001912	catalytic triad [active]
582744001913	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
582744001914	Tetramer interface [polypeptide binding]; other site
582744001915	Active site [active]
582744001916	FMN-binding site [chemical binding]; other site
582744001917	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
582744001918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744001919	putative substrate translocation pore; other site
582744001920	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
582744001921	catalytic motif [active]
582744001922	Catalytic residue [active]
582744001923	Uncharacterized ACR, COG1469; Region: DUF198; cl00642
582744001924	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
582744001925	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
582744001926	TPP-binding site; other site
582744001927	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
582744001928	PYR/PP interface [polypeptide binding]; other site
582744001929	dimer interface [polypeptide binding]; other site
582744001930	TPP binding site [chemical binding]; other site
582744001931	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
582744001932	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
582744001933	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
582744001934	substrate binding pocket [chemical binding]; other site
582744001935	chain length determination region; other site
582744001936	substrate-Mg2+ binding site; other site
582744001937	catalytic residues [active]
582744001938	aspartate-rich region 1; other site
582744001939	active site lid residues [active]
582744001940	aspartate-rich region 2; other site
582744001941	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
582744001942	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744001943	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
582744001944	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744001945	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
582744001946	Pilin (bacterial filament); Region: Pilin; pfam00114
582744001947	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
582744001948	putative hydrophobic ligand binding site [chemical binding]; other site
582744001949	protein interface [polypeptide binding]; other site
582744001950	gate; other site
582744001951	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582744001952	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
582744001953	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582744001954	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582744001955	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582744001956	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
582744001957	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671
582744001958	putative active site [active]
582744001959	Ap4A binding site [chemical binding]; other site
582744001960	nudix motif; other site
582744001961	putative metal binding site [ion binding]; other site
582744001962	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
582744001963	ketol-acid reductoisomerase; Provisional; Region: PRK05479
582744001964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744001965	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
582744001966	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
582744001967	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
582744001968	putative valine binding site [chemical binding]; other site
582744001969	dimer interface [polypeptide binding]; other site
582744001970	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
582744001971	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
582744001972	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
582744001973	PYR/PP interface [polypeptide binding]; other site
582744001974	dimer interface [polypeptide binding]; other site
582744001975	TPP binding site [chemical binding]; other site
582744001976	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
582744001977	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
582744001978	TPP-binding site [chemical binding]; other site
582744001979	dimer interface [polypeptide binding]; other site
582744001980	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
582744001981	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
582744001982	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
582744001983	Walker A motif; other site
582744001984	ATP binding site [chemical binding]; other site
582744001985	Walker B motif; other site
582744001986	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
582744001987	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572
582744001988	dimerization interface [polypeptide binding]; other site
582744001989	active site
582744001990	putative glutathione S-transferase; Provisional; Region: PRK10357
582744001991	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
582744001992	putative C-terminal domain interface [polypeptide binding]; other site
582744001993	putative GSH binding site (G-site) [chemical binding]; other site
582744001994	putative dimer interface [polypeptide binding]; other site
582744001995	GST_C family, unknown subfamily 6; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_6; cd03205
582744001996	putative N-terminal domain interface [polypeptide binding]; other site
582744001997	putative dimer interface [polypeptide binding]; other site
582744001998	putative substrate binding pocket (H-site) [chemical binding]; other site
582744001999	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
582744002000	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
582744002001	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675
582744002002	nudix motif; other site
582744002003	MarC family integral membrane protein; Region: MarC; cl00919
582744002004	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
582744002005	conserved cys residue [active]
582744002006	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
582744002007	active site
582744002008	dimer interface [polypeptide binding]; other site
582744002009	ribonuclease G; Provisional; Region: PRK11712
582744002010	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
582744002011	homodimer interface [polypeptide binding]; other site
582744002012	oligonucleotide binding site [chemical binding]; other site
582744002013	YGGT family; Region: YGGT; cl00508
582744002014	YGGT family; Region: YGGT; cl00508
582744002015	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
582744002016	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744002017	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
582744002018	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582744002019	catalytic residue [active]
582744002020	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
582744002021	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
582744002022	Walker A motif; other site
582744002023	ATP binding site [chemical binding]; other site
582744002024	Walker B motif; other site
582744002025	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
582744002026	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
582744002027	Walker A motif; other site
582744002028	ATP binding site [chemical binding]; other site
582744002029	Walker B motif; other site
582744002030	Protein of unknown function DUF72; Region: DUF72; cl00777
582744002031	dihydroorotase; Provisional; Region: PRK07627
582744002032	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
582744002033	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317
582744002034	active site
582744002035	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
582744002036	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
582744002037	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
582744002038	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
582744002039	Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525
582744002040	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
582744002041	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
582744002042	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
582744002043	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
582744002044	dimerization interface [polypeptide binding]; other site
582744002045	active site
582744002046	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
582744002047	Lumazine binding domain; Region: Lum_binding; pfam00677
582744002048	Lumazine binding domain; Region: Lum_binding; pfam00677
582744002049	LolC/E family; Region: lolCE; TIGR02212
582744002050	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582744002051	FtsX-like permease family; Region: FtsX; pfam02687
582744002052	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
582744002053	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
582744002054	Walker A/P-loop; other site
582744002055	ATP binding site [chemical binding]; other site
582744002056	Q-loop/lid; other site
582744002057	ABC transporter signature motif; other site
582744002058	Walker B; other site
582744002059	D-loop; other site
582744002060	H-loop/switch region; other site
582744002061	Competence protein; Region: Competence; cl00471
582744002062	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744002063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744002064	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
582744002065	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
582744002066	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
582744002067	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582744002068	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
582744002069	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
582744002070	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
582744002071	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
582744002072	Walker A/P-loop; other site
582744002073	ATP binding site [chemical binding]; other site
582744002074	Q-loop/lid; other site
582744002075	ABC transporter signature motif; other site
582744002076	Walker B; other site
582744002077	D-loop; other site
582744002078	H-loop/switch region; other site
582744002079	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
582744002080	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
582744002081	Trm112p-like protein; Region: Trm112p; cl01066
582744002082	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
582744002083	Ligand binding site [chemical binding]; other site
582744002084	oligomer interface [polypeptide binding]; other site
582744002085	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
582744002086	Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856
582744002087	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
582744002088	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582744002089	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
582744002090	P-loop; other site
582744002091	Magnesium ion binding site [ion binding]; other site
582744002092	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
582744002093	Magnesium ion binding site [ion binding]; other site
582744002094	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
582744002095	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
582744002096	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
582744002097	cysteine synthases; Region: cysKM; TIGR01136
582744002098	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
582744002099	dimer interface [polypeptide binding]; other site
582744002100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744002101	catalytic residue [active]
582744002102	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
582744002103	FimV N-terminal domain; Region: FimV_core; TIGR03505
582744002104	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
582744002105	Flavin Reductases; Region: FlaRed; cl00801
582744002106	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
582744002107	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582744002108	active site
582744002109	HIGH motif; other site
582744002110	nucleotide binding site [chemical binding]; other site
582744002111	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582744002112	active site
582744002113	KMSKS motif; other site
582744002114	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
582744002115	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
582744002116	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744002117	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
582744002118	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
582744002119	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
582744002120	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582744002121	E3 interaction surface; other site
582744002122	lipoyl attachment site [posttranslational modification]; other site
582744002123	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
582744002124	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744002125	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744002126	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
582744002127	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
582744002128	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
582744002129	E3 interaction surface; other site
582744002130	lipoyl attachment site [posttranslational modification]; other site
582744002131	e3 binding domain; Region: E3_binding; pfam02817
582744002132	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
582744002133	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
582744002134	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
582744002135	dimer interface [polypeptide binding]; other site
582744002136	TPP-binding site [chemical binding]; other site
582744002137	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
582744002138	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433
582744002139	interface (dimer of trimers) [polypeptide binding]; other site
582744002140	Substrate-binding/catalytic site; other site
582744002141	Zn-binding sites [ion binding]; other site
582744002142	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582744002143	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582744002144	ligand binding site [chemical binding]; other site
582744002145	flexible hinge region; other site
582744002146	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744002147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744002148	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744002149	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
582744002150	putative active site [active]
582744002151	putative metal binding residues [ion binding]; other site
582744002152	signature motif; other site
582744002153	putative triphosphate binding site [ion binding]; other site
582744002154	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
582744002155	ParA-like protein; Provisional; Region: PHA02518
582744002156	P-loop; other site
582744002157	Magnesium ion binding site [ion binding]; other site
582744002158	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
582744002159	catalytic core [active]
582744002160	Sulfatase; Region: Sulfatase; cl10460
582744002161	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
582744002162	DHH family; Region: DHH; pfam01368
582744002163	DHHA1 domain; Region: DHHA1; pfam02272
582744002164	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
582744002165	substrate binding site [chemical binding]; other site
582744002166	dimer interface [polypeptide binding]; other site
582744002167	catalytic triad [active]
582744002168	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
582744002169	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419
582744002170	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539
582744002171	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417
582744002172	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
582744002173	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
582744002174	putative dimer interface [polypeptide binding]; other site
582744002175	[2Fe-2S] cluster binding site [ion binding]; other site
582744002176	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
582744002177	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
582744002178	SLBB domain; Region: SLBB; pfam10531
582744002179	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
582744002180	NADH dehydrogenase subunit G; Validated; Region: PRK09129
582744002181	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582744002182	catalytic loop [active]
582744002183	iron binding site [ion binding]; other site
582744002184	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
582744002185	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions...; Region: MopB_NDH-1_NuoG2; cd02772
582744002186	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929
582744002187	NADH dehydrogenase; Region: NADHdh; cl00469
582744002188	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
582744002189	4Fe-4S binding domain; Region: Fer4; cl02805
582744002190	4Fe-4S binding domain; Region: Fer4; cl02805
582744002191	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
582744002192	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
582744002193	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
582744002194	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
582744002195	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
582744002196	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
582744002197	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
582744002198	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
582744002199	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
582744002200	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
582744002201	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
582744002202	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
582744002203	dimer interface [polypeptide binding]; other site
582744002204	ADP-ribose binding site [chemical binding]; other site
582744002205	active site
582744002206	nudix motif; other site
582744002207	metal binding site [ion binding]; metal-binding site
582744002208	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
582744002209	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
582744002210	putative NAD(P) binding site [chemical binding]; other site
582744002211	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582744002212	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744002213	catalytic residue [active]
582744002214	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
582744002215	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002216	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002217	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002218	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002219	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002220	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002221	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
582744002222	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
582744002223	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
582744002224	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
582744002225	putative ligand binding site [chemical binding]; other site
582744002226	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
582744002227	TM-ABC transporter signature motif; other site
582744002228	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
582744002229	TM-ABC transporter signature motif; other site
582744002230	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
582744002231	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
582744002232	Walker A/P-loop; other site
582744002233	ATP binding site [chemical binding]; other site
582744002234	Q-loop/lid; other site
582744002235	ABC transporter signature motif; other site
582744002236	Walker B; other site
582744002237	D-loop; other site
582744002238	H-loop/switch region; other site
582744002239	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
582744002240	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
582744002241	Walker A/P-loop; other site
582744002242	ATP binding site [chemical binding]; other site
582744002243	Q-loop/lid; other site
582744002244	ABC transporter signature motif; other site
582744002245	Walker B; other site
582744002246	D-loop; other site
582744002247	H-loop/switch region; other site
582744002248	UreD urease accessory protein; Region: UreD; cl00530
582744002249	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
582744002250	alpha-gamma subunit interface [polypeptide binding]; other site
582744002251	beta-gamma subunit interface [polypeptide binding]; other site
582744002252	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407
582744002253	gamma-beta subunit interface [polypeptide binding]; other site
582744002254	alpha-beta subunit interface [polypeptide binding]; other site
582744002255	urease subunit alpha; Reviewed; Region: ureC; PRK13207
582744002256	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
582744002257	subunit interactions [polypeptide binding]; other site
582744002258	active site
582744002259	flap region; other site
582744002260	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571
582744002261	dimer interface [polypeptide binding]; other site
582744002262	catalytic residues [active]
582744002263	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
582744002264	UreF; Region: UreF; pfam01730
582744002265	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744002266	HupE / UreJ protein; Region: HupE_UreJ; cl01011
582744002267	Sodium:solute symporter family; Region: SSF; cl00456
582744002268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744002269	dimer interface [polypeptide binding]; other site
582744002270	phosphorylation site [posttranslational modification]
582744002271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744002272	ATP binding site [chemical binding]; other site
582744002273	Mg2+ binding site [ion binding]; other site
582744002274	G-X-G motif; other site
582744002275	Response regulator receiver domain; Region: Response_reg; pfam00072
582744002276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002277	active site
582744002278	phosphorylation site [posttranslational modification]
582744002279	intermolecular recognition site; other site
582744002280	dimerization interface [polypeptide binding]; other site
582744002281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002282	active site
582744002283	phosphorylation site [posttranslational modification]
582744002284	intermolecular recognition site; other site
582744002285	dimerization interface [polypeptide binding]; other site
582744002286	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744002287	DNA binding residues [nucleotide binding]
582744002288	dimerization interface [polypeptide binding]; other site
582744002289	Catalytic domain of Protein Kinases; Region: PKc; cd00180
582744002290	active site
582744002291	ATP binding site [chemical binding]; other site
582744002292	substrate binding site [chemical binding]; other site
582744002293	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
582744002294	activation loop (A-loop); other site
582744002295	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744002296	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
582744002297	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582744002298	endonuclease III; Region: ENDO3c; smart00478
582744002299	minor groove reading motif; other site
582744002300	helix-hairpin-helix signature motif; other site
582744002301	substrate binding pocket [chemical binding]; other site
582744002302	active site
582744002303	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
582744002304	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667
582744002305	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
582744002306	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
582744002307	active site
582744002308	dimer interface [polypeptide binding]; other site
582744002309	motif 1; other site
582744002310	motif 2; other site
582744002311	motif 3; other site
582744002312	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
582744002313	anticodon binding site; other site
582744002314	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
582744002315	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
582744002316	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
582744002317	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
582744002318	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
582744002319	23S rRNA binding site [nucleotide binding]; other site
582744002320	L21 binding site [polypeptide binding]; other site
582744002321	L13 binding site [polypeptide binding]; other site
582744002322	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
582744002323	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
582744002324	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
582744002325	dimer interface [polypeptide binding]; other site
582744002326	motif 1; other site
582744002327	active site
582744002328	motif 2; other site
582744002329	motif 3; other site
582744002330	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
582744002331	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
582744002332	putative tRNA-binding site [nucleotide binding]; other site
582744002333	B3/4 domain; Region: B3_4; cl11458
582744002334	tRNA synthetase B5 domain; Region: B5; cl08394
582744002335	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
582744002336	dimer interface [polypeptide binding]; other site
582744002337	motif 1; other site
582744002338	motif 3; other site
582744002339	motif 2; other site
582744002340	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
582744002341	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
582744002342	IHF - DNA interface [nucleotide binding]; other site
582744002343	IHF dimer interface [polypeptide binding]; other site
582744002344	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
582744002345	DNA binding residues [nucleotide binding]
582744002346	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
582744002347	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744002348	N-terminal plug; other site
582744002349	ligand-binding site [chemical binding]; other site
582744002350	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744002351	ATP binding site [chemical binding]; other site
582744002352	putative Mg++ binding site [ion binding]; other site
582744002353	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744002354	nucleotide binding region [chemical binding]; other site
582744002355	ATP-binding site [chemical binding]; other site
582744002356	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
582744002357	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
582744002358	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
582744002359	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
582744002360	Walker A motif; other site
582744002361	ATP binding site [chemical binding]; other site
582744002362	Walker B motif; other site
582744002363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744002364	putative substrate translocation pore; other site
582744002365	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
582744002366	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744002367	Histidine kinase; Region: HisKA_3; pfam07730
582744002368	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744002369	ATP binding site [chemical binding]; other site
582744002370	Mg2+ binding site [ion binding]; other site
582744002371	G-X-G motif; other site
582744002372	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582744002373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002374	active site
582744002375	phosphorylation site [posttranslational modification]
582744002376	intermolecular recognition site; other site
582744002377	dimerization interface [polypeptide binding]; other site
582744002378	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744002379	DNA binding residues [nucleotide binding]
582744002380	dimerization interface [polypeptide binding]; other site
582744002381	response regulator; Provisional; Region: PRK09483
582744002382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002383	active site
582744002384	phosphorylation site [posttranslational modification]
582744002385	intermolecular recognition site; other site
582744002386	dimerization interface [polypeptide binding]; other site
582744002387	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744002388	DNA binding residues [nucleotide binding]
582744002389	dimerization interface [polypeptide binding]; other site
582744002390	Histidine kinase; Region: HisKA_3; pfam07730
582744002391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744002392	ATP binding site [chemical binding]; other site
582744002393	Mg2+ binding site [ion binding]; other site
582744002394	G-X-G motif; other site
582744002395	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582744002396	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216
582744002397	Trp docking motif; other site
582744002398	'Velcro' closure; other site
582744002399	active site
582744002400	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744002401	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
582744002402	Cytochrome c; Region: Cytochrom_C; cl11414
582744002403	Methanol dehydrogenase beta subunit; Region: MDH; pfam02315
582744002404	MoxR-like ATPases [General function prediction only]; Region: COG0714
582744002405	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744002406	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
582744002407	Protein of unknown function DUF58; Region: DUF58; pfam01882
582744002408	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
582744002409	metal ion-dependent adhesion site (MIDAS); other site
582744002410	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582744002411	metal ion-dependent adhesion site (MIDAS); other site
582744002412	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
582744002413	putative hydrophobic ligand binding site [chemical binding]; other site
582744002414	protein interface [polypeptide binding]; other site
582744002415	gate; other site
582744002416	hypothetical protein; Provisional; Region: PRK13560
582744002417	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
582744002418	Histidine kinase; Region: HisKA_3; pfam07730
582744002419	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744002420	ATP binding site [chemical binding]; other site
582744002421	Mg2+ binding site [ion binding]; other site
582744002422	G-X-G motif; other site
582744002423	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582744002424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002425	active site
582744002426	phosphorylation site [posttranslational modification]
582744002427	intermolecular recognition site; other site
582744002428	dimerization interface [polypeptide binding]; other site
582744002429	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744002430	DNA binding residues [nucleotide binding]
582744002431	dimerization interface [polypeptide binding]; other site
582744002432	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582744002433	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
582744002434	FlaG protein; Region: FlaG; cl00591
582744002435	flagellar capping protein; Validated; Region: fliD; PRK08724
582744002436	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
582744002437	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
582744002438	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
582744002439	Flagellar protein FliS; Region: FliS; cl00654
582744002440	Flagellar protein FliT; Region: FliT; cl05125
582744002441	Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669
582744002442	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
582744002443	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
582744002444	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
582744002445	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
582744002446	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
582744002447	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
582744002448	FliG C-terminal domain; Region: FliG_C; pfam01706
582744002449	flagellar assembly protein H; Validated; Region: fliH; PRK05687
582744002450	Flagellar assembly protein FliH; Region: FliH; pfam02108
582744002451	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
582744002452	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
582744002453	Walker A motif/ATP binding site; other site
582744002454	Walker B motif; other site
582744002455	Flagellar FliJ protein; Region: FliJ; cl09161
582744002456	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
582744002457	Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669
582744002458	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
582744002459	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
582744002460	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
582744002461	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
582744002462	FliP family; Region: FliP; cl00593
582744002463	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
582744002464	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
582744002465	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
582744002466	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
582744002467	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
582744002468	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
582744002469	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
582744002470	Rod binding protein; Region: Rod-binding; cl01626
582744002471	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
582744002472	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
582744002473	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
582744002474	Flagellar L-ring protein; Region: FlgH; cl00905
582744002475	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
582744002476	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
582744002477	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
582744002478	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
582744002479	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
582744002480	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
582744002481	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
582744002482	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
582744002483	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
582744002484	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
582744002485	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
582744002486	Flagellar hook capping protein; Region: FlgD; cl04347
582744002487	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
582744002488	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
582744002489	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
582744002490	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
582744002491	SAF domain; Region: SAF; cl00555
582744002492	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
582744002493	FlgN protein; Region: FlgN; cl09176
582744002494	MgtC family; Region: MgtC; cl12207
582744002495	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
582744002496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744002497	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
582744002498	flagellar motor protein MotD; Reviewed; Region: PRK09038
582744002499	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582744002500	ligand binding site [chemical binding]; other site
582744002501	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582744002502	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
582744002503	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744002504	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
582744002505	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
582744002506	DNA binding residues [nucleotide binding]
582744002507	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
582744002508	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744002509	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
582744002510	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
582744002511	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744002512	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
582744002513	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
582744002514	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
582744002515	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
582744002516	Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012
582744002517	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
582744002518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744002519	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744002520	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744002521	N-terminal plug; other site
582744002522	ligand-binding site [chemical binding]; other site
582744002523	fec operon regulator FecR; Reviewed; Region: PRK09774
582744002524	FecR protein; Region: FecR; pfam04773
582744002525	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
582744002526	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744002527	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744002528	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582744002529	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744002530	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744002531	N-terminal plug; other site
582744002532	ligand-binding site [chemical binding]; other site
582744002533	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
582744002534	FecR protein; Region: FecR; pfam04773
582744002535	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
582744002536	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744002537	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744002538	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
582744002539	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744002540	N-terminal plug; other site
582744002541	ligand-binding site [chemical binding]; other site
582744002542	fec operon regulator FecR; Reviewed; Region: PRK09774
582744002543	FecR protein; Region: FecR; pfam04773
582744002544	RNA polymerase sigma factor; Provisional; Region: PRK12528
582744002545	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744002546	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
582744002547	DNA binding residues [nucleotide binding]
582744002548	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582744002549	flagellar motor protein MotB; Validated; Region: motB; PRK09041
582744002550	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582744002551	ligand binding site [chemical binding]; other site
582744002552	Response regulator receiver domain; Region: Response_reg; pfam00072
582744002553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002554	active site
582744002555	phosphorylation site [posttranslational modification]
582744002556	intermolecular recognition site; other site
582744002557	dimerization interface [polypeptide binding]; other site
582744002558	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582744002559	putative binding surface; other site
582744002560	active site
582744002561	CheY binding; Region: CheY-binding; pfam09078
582744002562	CheY binding; Region: CheY-binding; pfam09078
582744002563	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
582744002564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744002565	ATP binding site [chemical binding]; other site
582744002566	Mg2+ binding site [ion binding]; other site
582744002567	G-X-G motif; other site
582744002568	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
582744002569	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
582744002570	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
582744002571	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744002572	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744002573	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
582744002574	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
582744002575	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744002576	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744002577	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
582744002578	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
582744002579	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744002580	CheD chemotactic sensory transduction; Region: CheD; cl00810
582744002581	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
582744002582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002583	active site
582744002584	phosphorylation site [posttranslational modification]
582744002585	intermolecular recognition site; other site
582744002586	dimerization interface [polypeptide binding]; other site
582744002587	CheB methylesterase; Region: CheB_methylest; pfam01339
582744002588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002589	Response regulator receiver domain; Region: Response_reg; pfam00072
582744002590	active site
582744002591	phosphorylation site [posttranslational modification]
582744002592	intermolecular recognition site; other site
582744002593	dimerization interface [polypeptide binding]; other site
582744002594	Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219
582744002595	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
582744002596	phosphoglucomutase; Region: PLN02307
582744002597	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one...; Region: PGM1; cd03085
582744002598	substrate binding site [chemical binding]; other site
582744002599	dimer interface [polypeptide binding]; other site
582744002600	active site
582744002601	metal binding site [ion binding]; metal-binding site
582744002602	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
582744002603	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
582744002604	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744002605	Walker A/P-loop; other site
582744002606	ATP binding site [chemical binding]; other site
582744002607	Q-loop/lid; other site
582744002608	ABC transporter signature motif; other site
582744002609	Walker B; other site
582744002610	D-loop; other site
582744002611	H-loop/switch region; other site
582744002612	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
582744002613	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
582744002614	putative ADP-binding pocket [chemical binding]; other site
582744002615	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
582744002616	catalytic motif [active]
582744002617	Catalytic residue [active]
582744002618	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
582744002619	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
582744002620	active site
582744002621	substrate binding site [chemical binding]; other site
582744002622	metal binding site [ion binding]; metal-binding site
582744002623	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
582744002624	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
582744002625	HemN C-terminal region; Region: HemN_C; pfam06969
582744002626	Protein of unknown function (DUF528); Region: DUF528; cl01123
582744002627	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
582744002628	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
582744002629	active site
582744002630	FMN binding site [chemical binding]; other site
582744002631	substrate binding site [chemical binding]; other site
582744002632	homotetramer interface [polypeptide binding]; other site
582744002633	catalytic residue [active]
582744002634	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
582744002635	Fumarase C-terminus; Region: Fumerase_C; cl00795
582744002636	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
582744002637	dimer interface [polypeptide binding]; other site
582744002638	glycine-pyridoxal phosphate binding site [chemical binding]; other site
582744002639	active site
582744002640	folate binding site [chemical binding]; other site
582744002641	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
582744002642	ATP cone domain; Region: ATP-cone; pfam03477
582744002643	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
582744002644	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
582744002645	catalytic motif [active]
582744002646	Zn binding site [ion binding]; other site
582744002647	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
582744002648	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
582744002649	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
582744002650	active site
582744002651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002652	binding surface
582744002653	TPR motif; other site
582744002654	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
582744002655	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
582744002656	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002657	binding surface
582744002658	TPR motif; other site
582744002659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002660	binding surface
582744002661	TPR motif; other site
582744002662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002663	binding surface
582744002664	TPR motif; other site
582744002665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002666	binding surface
582744002667	TPR motif; other site
582744002668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002669	binding surface
582744002670	TPR motif; other site
582744002671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002672	binding surface
582744002673	TPR motif; other site
582744002674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002675	binding surface
582744002676	TPR motif; other site
582744002677	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
582744002678	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582744002679	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
582744002680	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
582744002681	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
582744002682	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582744002683	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
582744002684	Pilus assembly protein, PilO; Region: PilO; cl01234
582744002685	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
582744002686	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
582744002687	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
582744002688	Walker A motif; other site
582744002689	ATP binding site [chemical binding]; other site
582744002690	Walker B motif; other site
582744002691	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
582744002692	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744002693	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744002694	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
582744002695	general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710
582744002696	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
582744002697	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002698	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002699	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002700	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582744002701	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
582744002702	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
582744002703	Autotransporter beta-domain; Region: Autotransporter; cl02365
582744002704	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
582744002705	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
582744002706	intersubunit interface [polypeptide binding]; other site
582744002707	active site
582744002708	Zn2+ binding site [ion binding]; other site
582744002709	putative carbohydrate kinase; Provisional; Region: PRK10565
582744002710	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
582744002711	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
582744002712	putative substrate binding site [chemical binding]; other site
582744002713	putative ATP binding site [chemical binding]; other site
582744002714	CTP synthetase; Validated; Region: pyrG; PRK05380
582744002715	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
582744002716	Catalytic site [active]
582744002717	Active site [active]
582744002718	UTP binding site [chemical binding]; other site
582744002719	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
582744002720	active site
582744002721	putative oxyanion hole; other site
582744002722	catalytic triad [active]
582744002723	NeuB family; Region: NeuB; cl00496
582744002724	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
582744002725	enolase; Provisional; Region: eno; PRK00077
582744002726	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
582744002727	dimer interface [polypeptide binding]; other site
582744002728	metal binding site [ion binding]; metal-binding site
582744002729	substrate binding pocket [chemical binding]; other site
582744002730	Septum formation initiator; Region: DivIC; cl11433
582744002731	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744002732	metal binding site [ion binding]; metal-binding site
582744002733	active site
582744002734	I-site; other site
582744002735	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002736	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744002737	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
582744002738	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
582744002739	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582744002740	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582744002741	metal ion-dependent adhesion site (MIDAS); other site
582744002742	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
582744002743	metal ion-dependent adhesion site (MIDAS); other site
582744002744	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
582744002745	MoxR-like ATPases [General function prediction only]; Region: COG0714
582744002746	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744002747	Walker A motif; other site
582744002748	ATP binding site [chemical binding]; other site
582744002749	Walker B motif; other site
582744002750	arginine finger; other site
582744002751	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
582744002752	active site 1 [active]
582744002753	dimer interface [polypeptide binding]; other site
582744002754	active site 2 [active]
582744002755	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
582744002756	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582744002757	dimer interface [polypeptide binding]; other site
582744002758	active site
582744002759	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560
582744002760	alanine aminotransferase; Provisional; Region: PTZ00377
582744002761	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744002762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744002763	homodimer interface [polypeptide binding]; other site
582744002764	catalytic residue [active]
582744002765	homoserine dehydrogenase; Provisional; Region: PRK06349
582744002766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744002767	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
582744002768	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
582744002769	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
582744002770	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560
582744002771	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744002772	catalytic residue [active]
582744002773	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
582744002774	dimerization interface [polypeptide binding]; other site
582744002775	active site
582744002776	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
582744002777	BON domain; Region: BON; cl02771
582744002778	response regulator GlrR; Provisional; Region: PRK15115
582744002779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744002780	active site
582744002781	phosphorylation site [posttranslational modification]
582744002782	intermolecular recognition site; other site
582744002783	dimerization interface [polypeptide binding]; other site
582744002784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744002785	Walker A motif; other site
582744002786	ATP binding site [chemical binding]; other site
582744002787	Walker B motif; other site
582744002788	arginine finger; other site
582744002789	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
582744002790	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744002791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744002792	dimer interface [polypeptide binding]; other site
582744002793	phosphorylation site [posttranslational modification]
582744002794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744002795	ATP binding site [chemical binding]; other site
582744002796	Mg2+ binding site [ion binding]; other site
582744002797	G-X-G motif; other site
582744002798	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
582744002799	folate binding site [chemical binding]; other site
582744002800	NADP+ binding site [chemical binding]; other site
582744002801	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002802	binding surface
582744002803	TPR motif; other site
582744002804	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744002805	TPR motif; other site
582744002806	binding surface
582744002807	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
582744002808	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582744002809	arginine decarboxylase; Provisional; Region: PRK15029
582744002810	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
582744002811	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582744002812	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744002813	catalytic residue [active]
582744002814	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
582744002815	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
582744002816	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744002817	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
582744002818	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
582744002819	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744002820	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
582744002821	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
582744002822	RNB domain; Region: RNB; pfam00773
582744002823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744002824	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
582744002825	THUMP domain; Region: THUMP; cl12076
582744002826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744002827	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
582744002828	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
582744002829	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
582744002830	dimerization interface [polypeptide binding]; other site
582744002831	ATP binding site [chemical binding]; other site
582744002832	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
582744002833	dimerization interface [polypeptide binding]; other site
582744002834	ATP binding site [chemical binding]; other site
582744002835	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
582744002836	putative active site [active]
582744002837	catalytic triad [active]
582744002838	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
582744002839	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582744002840	Cytochrome c; Region: Cytochrom_C; cl11414
582744002841	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
582744002842	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
582744002843	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
582744002844	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
582744002845	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
582744002846	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
582744002847	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744002848	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
582744002849	motif II; other site
582744002850	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
582744002851	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
582744002852	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744002853	CoA-ligase; Region: Ligase_CoA; pfam00549
582744002854	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
582744002855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744002856	CoA-ligase; Region: Ligase_CoA; pfam00549
582744002857	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582744002858	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
582744002859	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582744002860	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
582744002861	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582744002862	NAD synthetase; Provisional; Region: PRK13981
582744002863	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
582744002864	multimer interface [polypeptide binding]; other site
582744002865	active site
582744002866	catalytic triad [active]
582744002867	protein interface 1 [polypeptide binding]; other site
582744002868	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
582744002869	homodimer interface [polypeptide binding]; other site
582744002870	NAD binding pocket [chemical binding]; other site
582744002871	ATP binding pocket [chemical binding]; other site
582744002872	Mg binding site [ion binding]; other site
582744002873	active-site loop [active]
582744002874	Nitrogen regulatory protein P-II; Region: P-II; cl00412
582744002875	Protein of unknown function, DUF486; Region: DUF486; cl01236
582744002876	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
582744002877	Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions.  FeoB has been identified as part of this...; Region: FeoB; cd01879
582744002878	G1 box; other site
582744002879	GTP/Mg2+ binding site [chemical binding]; other site
582744002880	Switch I region; other site
582744002881	G2 box; other site
582744002882	G3 box; other site
582744002883	Switch II region; other site
582744002884	G4 box; other site
582744002885	G5 box; other site
582744002886	Nucleoside recognition; Region: Gate; cl00486
582744002887	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
582744002888	Nucleoside recognition; Region: Gate; cl00486
582744002889	FeoA domain; Region: FeoA; cl00838
582744002890	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
582744002891	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
582744002892	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
582744002893	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
582744002894	PPIC-type PPIASE domain; Region: Rotamase; cl08278
582744002895	BolA-like protein; Region: BolA; cl00386
582744002896	YCII-related domain; Region: YCII; cl00999
582744002897	Intracellular septation protein A; Region: IspA; cl01098
582744002898	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
582744002899	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
582744002900	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
582744002901	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
582744002902	active site
582744002903	putative substrate binding region [chemical binding]; other site
582744002904	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
582744002905	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
582744002906	active site
582744002907	HIGH motif; other site
582744002908	dimer interface [polypeptide binding]; other site
582744002909	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582744002910	active site
582744002911	KMSKS motif; other site
582744002912	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
582744002913	ScpA/B protein; Region: ScpA_ScpB; cl00598
582744002914	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
582744002915	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
582744002916	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582744002917	RNA binding surface [nucleotide binding]; other site
582744002918	PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556
582744002919	probable active site [active]
582744002920	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744002921	metal binding site [ion binding]; metal-binding site
582744002922	active site
582744002923	I-site; other site
582744002924	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744002925	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
582744002926	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744002927	N-terminal plug; other site
582744002928	ligand-binding site [chemical binding]; other site
582744002929	HemK family putative methylases; Region: hemK_fam; TIGR00536
582744002930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744002931	S-adenosylmethionine binding site [chemical binding]; other site
582744002932	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
582744002933	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
582744002934	metal binding site [ion binding]; metal-binding site
582744002935	dimer interface [polypeptide binding]; other site
582744002936	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
582744002937	putative catalytic residues [active]
582744002938	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
582744002939	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350
582744002940	trimer interface [polypeptide binding]; other site
582744002941	active site
582744002942	substrate binding site [chemical binding]; other site
582744002943	CoA binding site [chemical binding]; other site
582744002944	Peptidase family M48; Region: Peptidase_M48; cl12018
582744002945	potassium uptake protein; Region: kup; TIGR00794
582744002946	K+ potassium transporter; Region: K_trans; cl01227
582744002947	PEP-CTERM motif; Region: VPEP; pfam07589
582744002948	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
582744002949	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
582744002950	generic binding surface II; other site
582744002951	generic binding surface I; other site
582744002952	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
582744002953	cysteine synthases; Region: cysKM; TIGR01136
582744002954	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
582744002955	dimer interface [polypeptide binding]; other site
582744002956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744002957	catalytic residue [active]
582744002958	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
582744002959	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
582744002960	active site
582744002961	catalytic site [active]
582744002962	substrate binding site [chemical binding]; other site
582744002963	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
582744002964	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
582744002965	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744002966	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
582744002967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744002968	dimer interface [polypeptide binding]; other site
582744002969	conserved gate region; other site
582744002970	putative PBP binding loops; other site
582744002971	ABC-ATPase subunit interface; other site
582744002972	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
582744002973	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
582744002974	Walker A/P-loop; other site
582744002975	ATP binding site [chemical binding]; other site
582744002976	Q-loop/lid; other site
582744002977	ABC transporter signature motif; other site
582744002978	Walker B; other site
582744002979	D-loop; other site
582744002980	H-loop/switch region; other site
582744002981	Creatinine amidohydrolase; Region: Creatininase; cl00618
582744002982	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
582744002983	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582744002984	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
582744002985	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
582744002986	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
582744002987	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
582744002988	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
582744002989	urea carboxylase; Region: urea_carbox; TIGR02712
582744002990	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582744002991	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744002992	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
582744002993	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
582744002994	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
582744002995	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
582744002996	carboxyltransferase (CT) interaction site; other site
582744002997	biotinylation site [posttranslational modification]; other site
582744002998	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
582744002999	ethanolamine permease; Region: 2A0305; TIGR00908
582744003000	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
582744003001	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
582744003002	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205
582744003003	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
582744003004	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
582744003005	HSP70 interaction site [polypeptide binding]; other site
582744003006	NeuB family; Region: NeuB; cl00496
582744003007	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
582744003008	transcriptional regulator EutR; Provisional; Region: PRK10130
582744003009	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
582744003010	TRAM domain; Region: TRAM; cl01282
582744003011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744003012	S-adenosylmethionine binding site [chemical binding]; other site
582744003013	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582744003014	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582744003015	Coenzyme A binding pocket [chemical binding]; other site
582744003016	Isochorismatase family; Region: Isochorismatase; pfam00857
582744003017	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
582744003018	catalytic triad [active]
582744003019	conserved cis-peptide bond; other site
582744003020	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
582744003021	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
582744003022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
582744003023	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582744003024	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
582744003025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
582744003026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744003027	putative PBP binding loops; other site
582744003028	dimer interface [polypeptide binding]; other site
582744003029	ABC-ATPase subunit interface; other site
582744003030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744003031	dimer interface [polypeptide binding]; other site
582744003032	conserved gate region; other site
582744003033	putative PBP binding loops; other site
582744003034	ABC-ATPase subunit interface; other site
582744003035	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
582744003036	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
582744003037	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181
582744003038	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
582744003039	nucleoside/Zn binding site; other site
582744003040	dimer interface [polypeptide binding]; other site
582744003041	catalytic motif [active]
582744003042	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
582744003043	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
582744003044	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
582744003045	Protein of unknown function DUF58; Region: DUF58; pfam01882
582744003046	MoxR-like ATPases [General function prediction only]; Region: COG0714
582744003047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744003048	Walker A motif; other site
582744003049	ATP binding site [chemical binding]; other site
582744003050	Walker B motif; other site
582744003051	arginine finger; other site
582744003052	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744003053	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
582744003054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744003055	dimerization interface [polypeptide binding]; other site
582744003056	Pirin-related protein [General function prediction only]; Region: COG1741
582744003057	Cupin domain; Region: Cupin_2; cl09118
582744003058	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
582744003059	YceI-like domain; Region: YceI; cl01001
582744003060	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
582744003061	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
582744003062	FMN binding site [chemical binding]; other site
582744003063	active site
582744003064	substrate binding site [chemical binding]; other site
582744003065	catalytic residue [active]
582744003066	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
582744003067	putative FMN binding site [chemical binding]; other site
582744003068	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
582744003069	catalytic residues [active]
582744003070	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
582744003071	putative peptidoglycan binding site; other site
582744003072	Peptidase family M23; Region: Peptidase_M23; pfam01551
582744003073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744003074	S-adenosylmethionine binding site [chemical binding]; other site
582744003075	Survival protein SurE; Region: SurE; cl00448
582744003076	Predicted membrane protein (DUF2069); Region: DUF2069; cl01299
582744003077	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
582744003078	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
582744003079	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
582744003080	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
582744003081	LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167
582744003082	putative metal binding site [ion binding]; other site
582744003083	LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879
582744003084	adenylosuccinate lyase; Provisional; Region: PRK09285
582744003085	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
582744003086	tetramer interface [polypeptide binding]; other site
582744003087	active site
582744003088	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582744003089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744003090	putative active site [active]
582744003091	heme pocket [chemical binding]; other site
582744003092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744003093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003094	metal binding site [ion binding]; metal-binding site
582744003095	active site
582744003096	I-site; other site
582744003097	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744003098	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
582744003099	Catalytic site [active]
582744003100	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
582744003101	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576
582744003102	substrate binding site [chemical binding]; other site
582744003103	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
582744003104	substrate binding site [chemical binding]; other site
582744003105	ligand binding site [chemical binding]; other site
582744003106	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
582744003107	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
582744003108	Protein of unknown function (DUF519); Region: DUF519; cl04492
582744003109	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
582744003110	E-class dimer interface [polypeptide binding]; other site
582744003111	P-class dimer interface [polypeptide binding]; other site
582744003112	active site
582744003113	Cu2+ binding site [ion binding]; other site
582744003114	Zn2+ binding site [ion binding]; other site
582744003115	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
582744003116	Ca2+ binding site [ion binding]; other site
582744003117	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
582744003118	Cation efflux family; Region: Cation_efflux; cl00316
582744003119	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
582744003120	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
582744003121	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
582744003122	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
582744003123	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
582744003124	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
582744003125	psiF repeat; Region: PsiF_repeat; pfam07769
582744003126	psiF repeat; Region: PsiF_repeat; pfam07769
582744003127	psiF repeat; Region: PsiF_repeat; pfam07769
582744003128	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
582744003129	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
582744003130	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
582744003131	ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245
582744003132	Walker A/P-loop; other site
582744003133	ATP binding site [chemical binding]; other site
582744003134	Q-loop/lid; other site
582744003135	ABC transporter signature motif; other site
582744003136	Walker B; other site
582744003137	D-loop; other site
582744003138	H-loop/switch region; other site
582744003139	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
582744003140	Outer membrane efflux protein; Region: OEP; pfam02321
582744003141	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582744003142	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744003143	DNA binding residues [nucleotide binding]
582744003144	dimerization interface [polypeptide binding]; other site
582744003145	VCBS repeat; Region: VCBS_repeat; TIGR01965
582744003146	VCBS repeat; Region: VCBS_repeat; TIGR01965
582744003147	VCBS repeat; Region: VCBS_repeat; TIGR01965
582744003148	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
582744003149	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
582744003150	metal ion-dependent adhesion site (MIDAS); other site
582744003151	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744003152	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744003153	biofilm formation regulator HmsP; Provisional; Region: PRK11829
582744003154	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744003155	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
582744003156	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744003157	Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479
582744003158	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
582744003159	Outer membrane efflux protein; Region: OEP; pfam02321
582744003160	Outer membrane efflux protein; Region: OEP; pfam02321
582744003161	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
582744003162	DNA photolyase; Region: DNA_photolyase; pfam00875
582744003163	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
582744003164	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
582744003165	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
582744003166	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
582744003167	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016
582744003168	dimer interface [polypeptide binding]; other site
582744003169	Alkaline phosphatase homologues; Region: alkPPc; smart00098
582744003170	active site
582744003171	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039
582744003172	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
582744003173	general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710
582744003174	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
582744003175	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744003176	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744003177	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
582744003178	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
582744003179	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
582744003180	Walker A motif; other site
582744003181	ATP binding site [chemical binding]; other site
582744003182	Walker B motif; other site
582744003183	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
582744003184	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
582744003185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744003186	binding surface
582744003187	TPR motif; other site
582744003188	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
582744003189	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
582744003190	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
582744003191	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
582744003192	Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334
582744003193	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
582744003194	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582744003195	catalytic residue [active]
582744003196	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
582744003197	catalytic triad [active]
582744003198	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_17; cd08356
582744003199	Chromate transporter; Region: Chromate_transp; pfam02417
582744003200	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
582744003201	Chromate transporter; Region: Chromate_transp; pfam02417
582744003202	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
582744003203	PEP-CTERM motif; Region: VPEP; pfam07589
582744003204	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
582744003205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744003206	TPR motif; other site
582744003207	binding surface
582744003208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744003209	binding surface
582744003210	TPR motif; other site
582744003211	Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968
582744003212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744003213	binding surface
582744003214	TPR motif; other site
582744003215	conserved hypothetical protein; Region: TIGR02466
582744003216	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
582744003217	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744003218	N-terminal plug; other site
582744003219	ligand-binding site [chemical binding]; other site
582744003220	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
582744003221	Uncharacterized conserved protein [Function unknown]; Region: COG5591
582744003222	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
582744003223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
582744003224	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
582744003225	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744003226	N-terminal plug; other site
582744003227	ligand-binding site [chemical binding]; other site
582744003228	ABC transporter ATPase component; Reviewed; Region: PRK11147
582744003229	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744003230	Walker A/P-loop; other site
582744003231	ATP binding site [chemical binding]; other site
582744003232	Q-loop/lid; other site
582744003233	ABC transporter signature motif; other site
582744003234	Walker B; other site
582744003235	D-loop; other site
582744003236	H-loop/switch region; other site
582744003237	ABC transporter; Region: ABC_tran_2; pfam12848
582744003238	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
582744003239	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
582744003240	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
582744003241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744003242	active site
582744003243	phosphorylation site [posttranslational modification]
582744003244	intermolecular recognition site; other site
582744003245	dimerization interface [polypeptide binding]; other site
582744003246	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
582744003247	DNA binding site [nucleotide binding]
582744003248	sensor protein KdpD; Provisional; Region: PRK10490
582744003249	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
582744003250	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
582744003251	Ligand Binding Site [chemical binding]; other site
582744003252	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744003253	dimer interface [polypeptide binding]; other site
582744003254	phosphorylation site [posttranslational modification]
582744003255	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744003256	ATP binding site [chemical binding]; other site
582744003257	Mg2+ binding site [ion binding]; other site
582744003258	G-X-G motif; other site
582744003259	K+-transporting ATPase, c chain; Region: KdpC; cl00944
582744003260	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
582744003261	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582744003262	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903
582744003263	Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814
582744003264	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744003265	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582744003266	putative substrate translocation pore; other site
582744003267	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
582744003268	UvrD/REP helicase; Region: UvrD-helicase; cl14126
582744003269	UvrD/REP helicase; Region: UvrD-helicase; cl14126
582744003270	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003271	metal binding site [ion binding]; metal-binding site
582744003272	active site
582744003273	I-site; other site
582744003274	MEKHLA domain; Region: MEKHLA; pfam08670
582744003275	CHASE3 domain; Region: CHASE3; cl05000
582744003276	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003277	metal binding site [ion binding]; metal-binding site
582744003278	active site
582744003279	I-site; other site
582744003280	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
582744003281	YlqF.  Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856
582744003282	GTP/Mg2+ binding site [chemical binding]; other site
582744003283	G4 box; other site
582744003284	G5 box; other site
582744003285	G1 box; other site
582744003286	Switch I region; other site
582744003287	G2 box; other site
582744003288	G3 box; other site
582744003289	Switch II region; other site
582744003290	ApbE family; Region: ApbE; cl00643
582744003291	FMN-binding domain; Region: FMN_bind; cl01081
582744003292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744003293	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
582744003294	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
582744003295	MG2 domain; Region: A2M_N; pfam01835
582744003296	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
582744003297	Alpha-2-macroglobulin family; Region: A2M; pfam00207
582744003298	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
582744003299	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
582744003300	Transglycosylase; Region: Transgly; cl07896
582744003301	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
582744003302	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
582744003303	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
582744003304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582744003305	ATP binding site [chemical binding]; other site
582744003306	putative Mg++ binding site [ion binding]; other site
582744003307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744003308	Helicase associated domain (HA2); Region: HA2; cl04503
582744003309	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
582744003310	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
582744003311	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744003312	NodT family; Region: outer_NodT; TIGR01845
582744003313	Outer membrane efflux protein; Region: OEP; pfam02321
582744003314	Outer membrane efflux protein; Region: OEP; pfam02321
582744003315	Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136
582744003316	Fusaric acid resistance protein family; Region: FUSC; pfam04632
582744003317	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
582744003318	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
582744003319	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
582744003320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744003321	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744003322	dimerization interface [polypeptide binding]; other site
582744003323	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
582744003324	N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
582744003325	THF binding site; other site
582744003326	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
582744003327	substrate binding site [chemical binding]; other site
582744003328	THF binding site; other site
582744003329	zinc-binding site [ion binding]; other site
582744003330	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
582744003331	EamA-like transporter family; Region: EamA; cl01037
582744003332	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
582744003333	ATP cone domain; Region: ATP-cone; pfam03477
582744003334	Class I ribonucleotide reductase; Region: RNR_I; cd01679
582744003335	active site
582744003336	dimer interface [polypeptide binding]; other site
582744003337	catalytic residues [active]
582744003338	effector binding site; other site
582744003339	R2 peptide binding site; other site
582744003340	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
582744003341	dimer interface [polypeptide binding]; other site
582744003342	putative radical transfer pathway; other site
582744003343	diiron center [ion binding]; other site
582744003344	tyrosyl radical; other site
582744003345	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
582744003346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582744003347	ATP binding site [chemical binding]; other site
582744003348	putative Mg++ binding site [ion binding]; other site
582744003349	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
582744003350	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
582744003351	HsdM N-terminal domain; Region: HsdM_N; pfam12161
582744003352	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
582744003353	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
582744003354	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
582744003355	trimer interface [polypeptide binding]; other site
582744003356	active site
582744003357	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
582744003358	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
582744003359	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
582744003360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744003361	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
582744003362	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
582744003363	putative active site [active]
582744003364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744003365	Domain of unknown function DUF59; Region: DUF59; cl00941
582744003366	antiporter inner membrane protein; Provisional; Region: PRK11670
582744003367	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
582744003368	Walker A motif; other site
582744003369	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
582744003370	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
582744003371	active site
582744003372	HIGH motif; other site
582744003373	KMSKS motif; other site
582744003374	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
582744003375	tRNA binding surface [nucleotide binding]; other site
582744003376	anticodon binding site; other site
582744003377	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
582744003378	dimer interface [polypeptide binding]; other site
582744003379	putative tRNA-binding site [nucleotide binding]; other site
582744003380	comEA protein; Region: comE; TIGR01259
582744003381	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
582744003382	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
582744003383	active site
582744003384	dimer interface [polypeptide binding]; other site
582744003385	tetratricopeptide repeat protein; Provisional; Region: PRK11788
582744003386	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744003387	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
582744003388	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
582744003389	IHF dimer interface [polypeptide binding]; other site
582744003390	IHF - DNA interface [nucleotide binding]; other site
582744003391	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
582744003392	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
582744003393	RNA binding site [nucleotide binding]; other site
582744003394	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
582744003395	RNA binding site [nucleotide binding]; other site
582744003396	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
582744003397	RNA binding site [nucleotide binding]; other site
582744003398	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689
582744003399	RNA binding site [nucleotide binding]; other site
582744003400	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
582744003401	RNA binding site [nucleotide binding]; other site
582744003402	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691
582744003403	RNA binding site [nucleotide binding]; other site
582744003404	cytidylate kinase; Provisional; Region: cmk; PRK00023
582744003405	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
582744003406	CMP-binding site; other site
582744003407	The sites determining sugar specificity; other site
582744003408	Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
582744003409	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
582744003410	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
582744003411	hinge; other site
582744003412	active site
582744003413	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
582744003414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744003415	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
582744003416	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
582744003417	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
582744003418	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006
582744003419	PAS domain S-box; Region: sensory_box; TIGR00229
582744003420	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744003421	putative active site [active]
582744003422	heme pocket [chemical binding]; other site
582744003423	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003424	metal binding site [ion binding]; metal-binding site
582744003425	active site
582744003426	I-site; other site
582744003427	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
582744003428	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
582744003429	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003430	metal binding site [ion binding]; metal-binding site
582744003431	active site
582744003432	I-site; other site
582744003433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582744003434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744003435	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582744003436	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744003437	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
582744003438	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
582744003439	hypothetical protein; Provisional; Region: PRK01254
582744003440	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
582744003441	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
582744003442	TraB family; Region: TraB; cl12050
582744003443	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
582744003444	Response regulator receiver domain; Region: Response_reg; pfam00072
582744003445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744003446	active site
582744003447	phosphorylation site [posttranslational modification]
582744003448	intermolecular recognition site; other site
582744003449	dimerization interface [polypeptide binding]; other site
582744003450	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582744003451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744003452	active site
582744003453	phosphorylation site [posttranslational modification]
582744003454	intermolecular recognition site; other site
582744003455	dimerization interface [polypeptide binding]; other site
582744003456	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744003457	DNA binding residues [nucleotide binding]
582744003458	dimerization interface [polypeptide binding]; other site
582744003459	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
582744003460	Ferritin-like domain; Region: Ferritin; pfam00210
582744003461	dinuclear metal binding motif [ion binding]; other site
582744003462	CHASE3 domain; Region: CHASE3; cl05000
582744003463	Histidine kinase; Region: HisKA_3; pfam07730
582744003464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744003465	ATP binding site [chemical binding]; other site
582744003466	Mg2+ binding site [ion binding]; other site
582744003467	G-X-G motif; other site
582744003468	BON domain; Region: BON; cl02771
582744003469	BON domain; Region: BON; cl02771
582744003470	BON domain; Region: BON; cl02771
582744003471	BON domain; Region: BON; cl02771
582744003472	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
582744003473	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
582744003474	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
582744003475	DEAD-like helicases superfamily; Region: DEXDc; smart00487
582744003476	ATP binding site [chemical binding]; other site
582744003477	Mg++ binding site [ion binding]; other site
582744003478	motif III; other site
582744003479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744003480	nucleotide binding region [chemical binding]; other site
582744003481	ATP-binding site [chemical binding]; other site
582744003482	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
582744003483	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582744003484	RNA binding surface [nucleotide binding]; other site
582744003485	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
582744003486	active site
582744003487	uracil binding [chemical binding]; other site
582744003488	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
582744003489	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
582744003490	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582744003491	active site
582744003492	dimer interface [polypeptide binding]; other site
582744003493	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
582744003494	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
582744003495	DAK2 domain; Region: Dak2; cl03685
582744003496	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
582744003497	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
582744003498	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
582744003499	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
582744003500	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
582744003501	dimerization interface [polypeptide binding]; other site
582744003502	domain crossover interface; other site
582744003503	redox-dependent activation switch; other site
582744003504	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582744003505	active site
582744003506	HIGH motif; other site
582744003507	nucleotide binding site [chemical binding]; other site
582744003508	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582744003509	active site
582744003510	KMSKS motif; other site
582744003511	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
582744003512	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
582744003513	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
582744003514	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744003515	Active site [active]
582744003516	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
582744003517	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
582744003518	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744003519	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
582744003520	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
582744003521	DNA binding site [nucleotide binding]
582744003522	active site
582744003523	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582744003524	dimerization interface [polypeptide binding]; other site
582744003525	putative DNA binding site [nucleotide binding]; other site
582744003526	putative Zn2+ binding site [ion binding]; other site
582744003527	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
582744003528	putative metal binding site [ion binding]; other site
582744003529	Low molecular weight phosphatase family; Region: LMWPc; cd00115
582744003530	Active site [active]
582744003531	Membrane transport protein; Region: Mem_trans; cl09117
582744003532	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
582744003533	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
582744003534	dimer interface [polypeptide binding]; other site
582744003535	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
582744003536	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
582744003537	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
582744003538	Outer membrane efflux protein; Region: OEP; pfam02321
582744003539	Outer membrane efflux protein; Region: OEP; pfam02321
582744003540	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
582744003541	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
582744003542	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
582744003543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744003544	dimer interface [polypeptide binding]; other site
582744003545	phosphorylation site [posttranslational modification]
582744003546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744003547	ATP binding site [chemical binding]; other site
582744003548	Mg2+ binding site [ion binding]; other site
582744003549	G-X-G motif; other site
582744003550	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582744003551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744003552	active site
582744003553	phosphorylation site [posttranslational modification]
582744003554	intermolecular recognition site; other site
582744003555	dimerization interface [polypeptide binding]; other site
582744003556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cl00209
582744003557	DNA binding site [nucleotide binding]
582744003558	Autotransporter beta-domain; Region: Autotransporter; cl02365
582744003559	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
582744003560	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
582744003561	active site
582744003562	DNA binding site [nucleotide binding]
582744003563	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
582744003564	Catalytic site [active]
582744003565	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
582744003566	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
582744003567	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744003568	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744003569	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
582744003570	Cupin domain; Region: Cupin_2; cl09118
582744003571	BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473
582744003572	PAS domain S-box; Region: sensory_box; TIGR00229
582744003573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744003574	putative active site [active]
582744003575	heme pocket [chemical binding]; other site
582744003576	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003577	metal binding site [ion binding]; metal-binding site
582744003578	active site
582744003579	I-site; other site
582744003580	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744003581	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
582744003582	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
582744003583	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
582744003584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744003585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744003586	S-adenosylmethionine binding site [chemical binding]; other site
582744003587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744003588	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
582744003589	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744003590	putative active site [active]
582744003591	heme pocket [chemical binding]; other site
582744003592	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003593	metal binding site [ion binding]; metal-binding site
582744003594	active site
582744003595	I-site; other site
582744003596	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744003597	Protein of unknown function (DUF779); Region: DUF779; cl01432
582744003598	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
582744003599	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
582744003600	NAD(P) binding site [chemical binding]; other site
582744003601	catalytic residues [active]
582744003602	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
582744003603	putative dimer interface [polypeptide binding]; other site
582744003604	[2Fe-2S] cluster binding site [ion binding]; other site
582744003605	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
582744003606	putative dimer interface [polypeptide binding]; other site
582744003607	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
582744003608	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
582744003609	SLBB domain; Region: SLBB; pfam10531
582744003610	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
582744003611	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
582744003612	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582744003613	catalytic loop [active]
582744003614	iron binding site [ion binding]; other site
582744003615	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
582744003616	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753
582744003617	[4Fe-4S] binding site [ion binding]; other site
582744003618	molybdopterin cofactor binding site; other site
582744003619	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508
582744003620	molybdopterin cofactor binding site; other site
582744003621	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
582744003622	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
582744003623	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
582744003624	substrate binding site [chemical binding]; other site
582744003625	dimer interface [polypeptide binding]; other site
582744003626	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
582744003627	homotrimer interaction site [polypeptide binding]; other site
582744003628	zinc binding site [ion binding]; other site
582744003629	CDP-binding sites; other site
582744003630	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582744003631	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582744003632	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
582744003633	Outer membrane efflux protein; Region: OEP; pfam02321
582744003634	Outer membrane efflux protein; Region: OEP; pfam02321
582744003635	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
582744003636	dimer interface [polypeptide binding]; other site
582744003637	metal binding site [ion binding]; metal-binding site
582744003638	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
582744003639	Smr domain; Region: Smr; cl02619
582744003640	thioredoxin reductase; Provisional; Region: PRK10262
582744003641	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744003642	Ferritin-like domain; Region: Ferritin; pfam00210
582744003643	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
582744003644	dimerization interface [polypeptide binding]; other site
582744003645	DPS ferroxidase diiron center [ion binding]; other site
582744003646	ion pore; other site
582744003647	DNA translocase FtsK; Provisional; Region: PRK10263
582744003648	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744003649	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
582744003650	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
582744003651	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
582744003652	recombination factor protein RarA; Reviewed; Region: PRK13342
582744003653	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744003654	Walker A motif; other site
582744003655	ATP binding site [chemical binding]; other site
582744003656	Walker B motif; other site
582744003657	arginine finger; other site
582744003658	MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440
582744003659	seryl-tRNA synthetase; Provisional; Region: PRK05431
582744003660	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
582744003661	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
582744003662	dimer interface [polypeptide binding]; other site
582744003663	active site
582744003664	motif 1; other site
582744003665	motif 2; other site
582744003666	motif 3; other site
582744003667	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
582744003668	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
582744003669	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
582744003670	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
582744003671	substrate binding pocket [chemical binding]; other site
582744003672	membrane-bound complex binding site; other site
582744003673	hinge residues; other site
582744003674	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
582744003675	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582744003676	catalytic residue [active]
582744003677	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
582744003678	FemAB family; Region: FemAB; cl11444
582744003679	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
582744003680	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582744003681	dimer interface [polypeptide binding]; other site
582744003682	active site
582744003683	Phosphopantetheine attachment site; Region: PP-binding; cl09936
582744003684	Esterase/lipase [General function prediction only]; Region: COG1647
582744003685	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
582744003686	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
582744003687	inhibitor-cofactor binding pocket; inhibition site
582744003688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744003689	catalytic residue [active]
582744003690	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744003691	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
582744003692	Cu(I) binding site [ion binding]; other site
582744003693	UbiA prenyltransferase family; Region: UbiA; cl00337
582744003694	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
582744003695	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582744003696	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
582744003697	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
582744003698	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
582744003699	Subunit III/VIIa interface [polypeptide binding]; other site
582744003700	Phospholipid binding site [chemical binding]; other site
582744003701	Subunit I/III interface [polypeptide binding]; other site
582744003702	Subunit III/VIb interface [polypeptide binding]; other site
582744003703	Subunit III/VIa interface; other site
582744003704	Subunit III/Vb interface [polypeptide binding]; other site
582744003705	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240
582744003706	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
582744003707	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
582744003708	Subunit I/III interface [polypeptide binding]; other site
582744003709	D-pathway; other site
582744003710	Subunit I/VIIc interface [polypeptide binding]; other site
582744003711	Subunit I/IV interface [polypeptide binding]; other site
582744003712	Subunit I/II interface [polypeptide binding]; other site
582744003713	Low-spin heme (heme a) binding site [chemical binding]; other site
582744003714	Subunit I/VIIa interface [polypeptide binding]; other site
582744003715	Subunit I/VIa interface [polypeptide binding]; other site
582744003716	Dimer interface; other site
582744003717	Putative water exit pathway; other site
582744003718	Binuclear center (heme a3/CuB) [ion binding]; other site
582744003719	K-pathway; other site
582744003720	Subunit I/Vb interface [polypeptide binding]; other site
582744003721	Putative proton exit pathway; other site
582744003722	Subunit I/VIb interface; other site
582744003723	Subunit I/VIc interface [polypeptide binding]; other site
582744003724	Electron transfer pathway; other site
582744003725	Subunit I/VIIIb interface [polypeptide binding]; other site
582744003726	Subunit I/VIIb interface [polypeptide binding]; other site
582744003727	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
582744003728	Cytochrome c; Region: Cytochrom_C; cl11414
582744003729	Integral membrane protein (DUF2244); Region: DUF2244; cl02302
582744003730	Yip1 domain; Region: Yip1; cl12048
582744003731	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
582744003732	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
582744003733	FtsX-like permease family; Region: FtsX; pfam02687
582744003734	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
582744003735	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
582744003736	Walker A/P-loop; other site
582744003737	ATP binding site [chemical binding]; other site
582744003738	Q-loop/lid; other site
582744003739	ABC transporter signature motif; other site
582744003740	Walker B; other site
582744003741	D-loop; other site
582744003742	H-loop/switch region; other site
582744003743	macrolide transporter subunit MacA; Provisional; Region: PRK11578
582744003744	Outer membrane efflux protein; Region: OEP; pfam02321
582744003745	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
582744003746	Outer membrane efflux protein; Region: OEP; pfam02321
582744003747	Outer membrane efflux protein; Region: OEP; pfam02321
582744003748	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
582744003749	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744003750	Walker A/P-loop; other site
582744003751	ATP binding site [chemical binding]; other site
582744003752	Q-loop/lid; other site
582744003753	ABC transporter signature motif; other site
582744003754	Walker B; other site
582744003755	D-loop; other site
582744003756	H-loop/switch region; other site
582744003757	ABC transporter; Region: ABC_tran_2; pfam12848
582744003758	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
582744003759	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
582744003760	dimer interface [polypeptide binding]; other site
582744003761	FMN binding site [chemical binding]; other site
582744003762	transcription elongation factor regulatory protein; Validated; Region: PRK06342
582744003763	C-term; Region: GreA_GreB; pfam01272
582744003764	GMP synthase; Reviewed; Region: guaA; PRK00074
582744003765	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
582744003766	AMP/PPi binding site [chemical binding]; other site
582744003767	candidate oxyanion hole; other site
582744003768	catalytic triad [active]
582744003769	potential glutamine specificity residues [chemical binding]; other site
582744003770	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
582744003771	ATP Binding subdomain [chemical binding]; other site
582744003772	Ligand Binding sites [chemical binding]; other site
582744003773	Dimerization subdomain; other site
582744003774	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
582744003775	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
582744003776	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
582744003777	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
582744003778	active site
582744003779	Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096
582744003780	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
582744003781	putative coenzyme Q binding site [chemical binding]; other site
582744003782	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
582744003783	SmpB-tmRNA interface; other site
582744003784	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
582744003785	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
582744003786	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
582744003787	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
582744003788	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
582744003789	elongation factor P; Validated; Region: PRK00529
582744003790	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
582744003791	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
582744003792	RNA binding site [nucleotide binding]; other site
582744003793	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
582744003794	RNA binding site [nucleotide binding]; other site
582744003795	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823
582744003796	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
582744003797	domain; Region: GreA_GreB_N; pfam03449
582744003798	C-term; Region: GreA_GreB; pfam01272
582744003799	probable DNA repair protein; Region: TIGR03623
582744003800	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
582744003801	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
582744003802	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
582744003803	UvrD/REP helicase; Region: UvrD-helicase; cl14126
582744003804	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
582744003805	UvrD/REP helicase; Region: UvrD-helicase; cl14126
582744003806	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
582744003807	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
582744003808	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744003809	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744003810	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744003811	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744003812	translocation protein TolB; Provisional; Region: tolB; PRK04792
582744003813	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
582744003814	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744003815	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
582744003816	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
582744003817	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582744003818	ATP binding site [chemical binding]; other site
582744003819	putative Mg++ binding site [ion binding]; other site
582744003820	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744003821	nucleotide binding region [chemical binding]; other site
582744003822	ATP-binding site [chemical binding]; other site
582744003823	TRCF domain; Region: TRCF; pfam03461
582744003824	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
582744003825	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
582744003826	Predicted amidohydrolase [General function prediction only]; Region: COG0388
582744003827	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
582744003828	putative active site [active]
582744003829	catalytic triad [active]
582744003830	dimer interface [polypeptide binding]; other site
582744003831	TIGR02099 family protein; Region: TIGR02099
582744003832	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
582744003833	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
582744003834	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744003835	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
582744003836	ABC transporter; Region: ABC_tran_2; pfam12848
582744003837	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
582744003838	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
582744003839	dimer interface [polypeptide binding]; other site
582744003840	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
582744003841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744003842	active site
582744003843	phosphorylation site [posttranslational modification]
582744003844	intermolecular recognition site; other site
582744003845	dimerization interface [polypeptide binding]; other site
582744003846	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
582744003847	DNA binding site [nucleotide binding]
582744003848	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744003849	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
582744003850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744003851	ATP binding site [chemical binding]; other site
582744003852	Mg2+ binding site [ion binding]; other site
582744003853	G-X-G motif; other site
582744003854	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582744003855	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582744003856	ligand binding site [chemical binding]; other site
582744003857	flexible hinge region; other site
582744003858	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744003859	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243
582744003860	lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598
582744003861	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
582744003862	Sulfatase; Region: Sulfatase; cl10460
582744003863	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
582744003864	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
582744003865	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
582744003866	aspartate aminotransferase; Provisional; Region: PRK08361
582744003867	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744003868	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744003869	homodimer interface [polypeptide binding]; other site
582744003870	catalytic residue [active]
582744003871	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
582744003872	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744003873	binding surface
582744003874	TPR motif; other site
582744003875	excinuclease ABC subunit B; Provisional; Region: PRK05298
582744003876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582744003877	ATP binding site [chemical binding]; other site
582744003878	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744003879	nucleotide binding region [chemical binding]; other site
582744003880	ATP-binding site [chemical binding]; other site
582744003881	Ultra-violet resistance protein B; Region: UvrB; pfam12344
582744003882	UvrB/uvrC motif; Region: UVR; pfam02151
582744003883	ribonuclease E; Reviewed; Region: rne; PRK10811
582744003884	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
582744003885	homodimer interface [polypeptide binding]; other site
582744003886	oligonucleotide binding site [chemical binding]; other site
582744003887	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
582744003888	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
582744003889	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
582744003890	active site
582744003891	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582744003892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
582744003893	motif II; other site
582744003894	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467
582744003895	iron-sulfur cluster [ion binding]; other site
582744003896	[2Fe-2S] cluster binding site [ion binding]; other site
582744003897	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
582744003898	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
582744003899	tandem repeat interface [polypeptide binding]; other site
582744003900	oligomer interface [polypeptide binding]; other site
582744003901	active site residues [active]
582744003902	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
582744003903	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
582744003904	active site
582744003905	dimer interface [polypeptide binding]; other site
582744003906	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
582744003907	dimer interface [polypeptide binding]; other site
582744003908	active site
582744003909	glycogen branching enzyme; Provisional; Region: PRK05402
582744003910	Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855
582744003911	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
582744003912	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
582744003913	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
582744003914	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
582744003915	ligand binding site [chemical binding]; other site
582744003916	oligomer interface [polypeptide binding]; other site
582744003917	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
582744003918	dimer interface [polypeptide binding]; other site
582744003919	N-terminal domain interface [polypeptide binding]; other site
582744003920	sulfate 1 binding site; other site
582744003921	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
582744003922	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
582744003923	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
582744003924	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
582744003925	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
582744003926	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
582744003927	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744003928	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain...; Region: CBS_pair_GGDEF_assoc; cd04598
582744003929	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003930	metal binding site [ion binding]; metal-binding site
582744003931	active site
582744003932	I-site; other site
582744003933	Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191
582744003934	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582744003935	active site
582744003936	Glycosyl hydrolases family 17; Region: Glyco_hydro_17; cl02191
582744003937	YdjC-like protein; Region: YdjC; cl01344
582744003938	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
582744003939	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
582744003940	Ligand binding site [chemical binding]; other site
582744003941	Putative Catalytic site [active]
582744003942	DXD motif; other site
582744003943	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
582744003944	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
582744003945	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
582744003946	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
582744003947	Localisation of periplasmic protein complexes; Region: AMIN; pfam11741
582744003948	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
582744003949	active site
582744003950	metal binding site [ion binding]; metal-binding site
582744003951	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
582744003952	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744003953	Beta-Casp domain; Region: Beta-Casp; pfam10996
582744003954	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
582744003955	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
582744003956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
582744003957	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
582744003958	ATP binding site [chemical binding]; other site
582744003959	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
582744003960	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
582744003961	substrate binding site [chemical binding]; other site
582744003962	dimer interface [polypeptide binding]; other site
582744003963	ATP binding site [chemical binding]; other site
582744003964	IPP transferase; Region: IPPT; cl00403
582744003965	aspartate aminotransferase; Provisional; Region: PRK08361
582744003966	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744003967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744003968	homodimer interface [polypeptide binding]; other site
582744003969	catalytic residue [active]
582744003970	Predicted permeases [General function prediction only]; Region: RarD; COG2962
582744003971	EamA-like transporter family; Region: EamA; cl01037
582744003972	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
582744003973	putative active site [active]
582744003974	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
582744003975	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744003976	ATP binding site [chemical binding]; other site
582744003977	Walker B motif; other site
582744003978	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744003979	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010
582744003980	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744003981	metal binding site [ion binding]; metal-binding site
582744003982	active site
582744003983	I-site; other site
582744003984	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
582744003985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744003986	binding surface
582744003987	TPR motif; other site
582744003988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744003989	binding surface
582744003990	TPR motif; other site
582744003991	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
582744003992	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744003993	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
582744003994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744003995	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
582744003996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744003997	S-adenosylmethionine binding site [chemical binding]; other site
582744003998	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
582744003999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744004000	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744004001	S-adenosylmethionine binding site [chemical binding]; other site
582744004002	Protein of unknown function (DUF1365); Region: DUF1365; cl01388
582744004003	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744004004	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
582744004005	Di-iron ligands [ion binding]; other site
582744004006	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
582744004007	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
582744004008	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
582744004009	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
582744004010	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
582744004011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744004012	S-adenosylmethionine binding site [chemical binding]; other site
582744004013	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
582744004014	DNA binding residues [nucleotide binding]
582744004015	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
582744004016	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
582744004017	Anti-sigma-K factor rskA; Region: RskA; cl02208
582744004018	RNA polymerase sigma factor; Provisional; Region: PRK12514
582744004019	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744004020	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744004021	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
582744004022	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582744004023	Trp docking motif; other site
582744004024	'Velcro' closure; other site
582744004025	active site
582744004026	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cl00248
582744004027	dimerization interface [polypeptide binding]; other site
582744004028	substrate binding site [chemical binding]; other site
582744004029	active site
582744004030	calcium binding site [ion binding]; other site
582744004031	PEP-CTERM motif; Region: VPEP; pfam07589
582744004032	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
582744004033	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
582744004034	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
582744004035	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
582744004036	Walker A/P-loop; other site
582744004037	ATP binding site [chemical binding]; other site
582744004038	Q-loop/lid; other site
582744004039	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470
582744004040	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
582744004041	ABC transporter signature motif; other site
582744004042	Walker B; other site
582744004043	D-loop; other site
582744004044	H-loop/switch region; other site
582744004045	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
582744004046	FtsZ protein binding site [polypeptide binding]; other site
582744004047	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
582744004048	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
582744004049	nucleotide binding pocket [chemical binding]; other site
582744004050	K-X-D-G motif; other site
582744004051	catalytic site [active]
582744004052	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
582744004053	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
582744004054	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
582744004055	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
582744004056	Dimer interface [polypeptide binding]; other site
582744004057	BRCT sequence motif; other site
582744004058	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
582744004059	active site
582744004060	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
582744004061	Moco binding site; other site
582744004062	metal coordination site [ion binding]; other site
582744004063	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
582744004064	DoxX; Region: DoxX; cl00976
582744004065	Conserved TM helix; Region: TM_helix; pfam05552
582744004066	Conserved TM helix; Region: TM_helix; pfam05552
582744004067	Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
582744004068	Cation efflux family; Region: Cation_efflux; cl00316
582744004069	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
582744004070	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
582744004071	putative active site [active]
582744004072	putative active site [active]
582744004073	catalytic site [active]
582744004074	catalytic site [active]
582744004075	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
582744004076	putative active site [active]
582744004077	catalytic site [active]
582744004078	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
582744004079	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
582744004080	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
582744004081	putative catalytic site [active]
582744004082	putative metal binding site [ion binding]; other site
582744004083	putative phosphate binding site [ion binding]; other site
582744004084	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
582744004085	Ca2+ binding site [ion binding]; other site
582744004086	Predicted outer membrane protein [Function unknown]; Region: COG3652
582744004087	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
582744004088	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
582744004089	NAD binding site [chemical binding]; other site
582744004090	catalytic Zn binding site [ion binding]; other site
582744004091	structural Zn binding site [ion binding]; other site
582744004092	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
582744004093	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
582744004094	inhibitor site; inhibition site
582744004095	active site
582744004096	dimer interface [polypeptide binding]; other site
582744004097	catalytic residue [active]
582744004098	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
582744004099	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
582744004100	NADP binding site [chemical binding]; other site
582744004101	active site
582744004102	steroid binding site; other site
582744004103	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582744004104	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744004105	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
582744004106	dimerization interface [polypeptide binding]; other site
582744004107	Predicted outer membrane protein [Function unknown]; Region: COG3652
582744004108	short chain dehydrogenase; Provisional; Region: PRK06701
582744004109	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
582744004110	NAD binding site [chemical binding]; other site
582744004111	metal binding site [ion binding]; metal-binding site
582744004112	active site
582744004113	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582744004114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744004115	active site
582744004116	phosphorylation site [posttranslational modification]
582744004117	intermolecular recognition site; other site
582744004118	dimerization interface [polypeptide binding]; other site
582744004119	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457
582744004120	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
582744004121	YceI-like domain; Region: YceI; cl01001
582744004122	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
582744004123	The Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily belongs to the M14 family of metallocarboxypeptidases (MCPs), and includes ASTE, which catalyzes the fifth and last step in arginine catabolism by the arginine...; Region: M14_ASTE_ASPA_like; cd06230
582744004124	active site
582744004125	Zn-binding site [ion binding]; other site
582744004126	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
582744004127	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
582744004128	metal-binding site [ion binding]
582744004129	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582744004130	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744004131	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
582744004132	DNA-binding site [nucleotide binding]; DNA binding site
582744004133	RNA-binding motif; other site
582744004134	CsbD-like; Region: CsbD; cl01272
582744004135	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744004136	DNA binding residues [nucleotide binding]
582744004137	dimerization interface [polypeptide binding]; other site
582744004138	Sodium:solute symporter family; Region: SSF; cl00456
582744004139	Peptidase family M23; Region: Peptidase_M23; pfam01551
582744004140	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
582744004141	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
582744004142	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
582744004143	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
582744004144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744004145	active site
582744004146	phosphorylation site [posttranslational modification]
582744004147	intermolecular recognition site; other site
582744004148	dimerization interface [polypeptide binding]; other site
582744004149	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744004150	DNA binding residues [nucleotide binding]
582744004151	dimerization interface [polypeptide binding]; other site
582744004152	ferredoxin-NADP reductase; Provisional; Region: PRK10926
582744004153	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
582744004154	FAD binding pocket [chemical binding]; other site
582744004155	FAD binding motif [chemical binding]; other site
582744004156	phosphate binding motif [ion binding]; other site
582744004157	beta-alpha-beta structure motif; other site
582744004158	NAD binding pocket [chemical binding]; other site
582744004159	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
582744004160	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
582744004161	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
582744004162	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582744004163	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582744004164	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
582744004165	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
582744004166	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582744004167	catalytic loop [active]
582744004168	iron binding site [ion binding]; other site
582744004169	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
582744004170	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
582744004171	Ligand binding site [chemical binding]; other site
582744004172	metal binding site [ion binding]; metal-binding site
582744004173	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
582744004174	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
582744004175	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582744004176	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744004177	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582744004178	putative effector binding pocket; other site
582744004179	dimerization interface [polypeptide binding]; other site
582744004180	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744004181	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
582744004182	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
582744004183	active site
582744004184	PilZ domain; Region: PilZ; cl01260
582744004185	DNA polymerase III subunit delta'; Validated; Region: PRK06964
582744004186	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744004187	thymidylate kinase; Validated; Region: tmk; PRK00698
582744004188	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
582744004189	TMP-binding site; other site
582744004190	ATP-binding site [chemical binding]; other site
582744004191	YceG-like family; Region: YceG; pfam02618
582744004192	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
582744004193	dimerization interface [polypeptide binding]; other site
582744004194	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
582744004195	Aminotransferase class IV; Region: Aminotran_4; pfam01063
582744004196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744004197	catalytic residue [active]
582744004198	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
582744004199	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
582744004200	dimer interface [polypeptide binding]; other site
582744004201	active site
582744004202	Phosphopantetheine attachment site; Region: PP-binding; cl09936
582744004203	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582744004204	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
582744004205	NAD(P) binding site [chemical binding]; other site
582744004206	homotetramer interface [polypeptide binding]; other site
582744004207	homodimer interface [polypeptide binding]; other site
582744004208	active site
582744004209	Acyl transferase domain; Region: Acyl_transf_1; cl08282
582744004210	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
582744004211	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
582744004212	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
582744004213	dimer interface [polypeptide binding]; other site
582744004214	active site
582744004215	CoA binding pocket [chemical binding]; other site
582744004216	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
582744004217	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
582744004218	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
582744004219	pyruvate carboxylase subunit A; Validated; Region: PRK07178
582744004220	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582744004221	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744004222	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
582744004223	pyruvate carboxylase subunit B; Validated; Region: PRK09282
582744004224	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
582744004225	active site
582744004226	catalytic residues [active]
582744004227	metal binding site [ion binding]; metal-binding site
582744004228	homodimer binding site [polypeptide binding]; other site
582744004229	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
582744004230	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
582744004231	carboxyltransferase (CT) interaction site; other site
582744004232	biotinylation site [posttranslational modification]; other site
582744004233	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
582744004234	active site
582744004235	dimer interface [polypeptide binding]; other site
582744004236	Uncharacterized conserved protein [Function unknown]; Region: COG5316
582744004237	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
582744004238	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
582744004239	RNA/DNA hybrid binding site [nucleotide binding]; other site
582744004240	active site
582744004241	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
582744004242	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
582744004243	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
582744004244	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351
582744004245	active site
582744004246	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
582744004247	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
582744004248	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
582744004249	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352
582744004250	trimer interface [polypeptide binding]; other site
582744004251	active site
582744004252	UDP-GlcNAc binding site [chemical binding]; other site
582744004253	lipid binding site [chemical binding]; lipid-binding site
582744004254	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
582744004255	Outer membrane protein (OmpH-like); Region: OmpH; cl08146
582744004256	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
582744004257	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
582744004258	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
582744004259	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
582744004260	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
582744004261	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
582744004262	Surface antigen; Region: Bac_surface_Ag; cl03097
582744004263	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
582744004264	zinc metallopeptidase RseP; Provisional; Region: PRK10779
582744004265	active site
582744004266	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
582744004267	protein binding site [polypeptide binding]; other site
582744004268	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
582744004269	protein binding site [polypeptide binding]; other site
582744004270	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
582744004271	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
582744004272	putative substrate binding region [chemical binding]; other site
582744004273	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
582744004274	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
582744004275	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
582744004276	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
582744004277	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
582744004278	catalytic residue [active]
582744004279	putative FPP diphosphate  binding site; other site
582744004280	putative FPP binding hydrophobic cleft; other site
582744004281	dimer interface [polypeptide binding]; other site
582744004282	putative IPP diphosphate binding site; other site
582744004283	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
582744004284	hinge region; other site
582744004285	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
582744004286	putative nucleotide binding site [chemical binding]; other site
582744004287	uridine monophosphate binding site [chemical binding]; other site
582744004288	homohexameric interface [polypeptide binding]; other site
582744004289	elongation factor Ts; Provisional; Region: tsf; PRK09377
582744004290	Elongation factor TS; Region: EF_TS; pfam00889
582744004291	Elongation factor TS; Region: EF_TS; pfam00889
582744004292	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
582744004293	rRNA interaction site [nucleotide binding]; other site
582744004294	S8 interaction site; other site
582744004295	putative laminin-1 binding site; other site
582744004296	methionine aminopeptidase; Reviewed; Region: PRK07281
582744004297	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
582744004298	active site
582744004299	PII uridylyl-transferase; Provisional; Region: PRK03059
582744004300	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582744004301	metal binding triad; other site
582744004302	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582744004303	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744004304	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
582744004305	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
582744004306	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
582744004307	active site
582744004308	DNA polymerase IV; Validated; Region: PRK02406
582744004309	DNA binding site [nucleotide binding]
582744004310	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582744004311	classical (c) SDRs; Region: SDR_c; cd05233
582744004312	NAD(P) binding site [chemical binding]; other site
582744004313	active site
582744004314	Cupin domain; Region: Cupin_2; cl09118
582744004315	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
582744004316	active site
582744004317	catalytic residues [active]
582744004318	metal binding site [ion binding]; metal-binding site
582744004319	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
582744004320	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
582744004321	active site lid residues [active]
582744004322	substrate binding pocket [chemical binding]; other site
582744004323	catalytic residues [active]
582744004324	substrate-Mg2+ binding site; other site
582744004325	aspartate-rich region 1; other site
582744004326	aspartate-rich region 2; other site
582744004327	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
582744004328	catalytic residues [active]
582744004329	substrate binding pocket [chemical binding]; other site
582744004330	substrate-Mg2+ binding site; other site
582744004331	aspartate-rich region 1; other site
582744004332	aspartate-rich region 2; other site
582744004333	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744004334	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
582744004335	Membrane protein of unknown function; Region: DUF360; cl00850
582744004336	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744004337	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
582744004338	NAD(P) binding site [chemical binding]; other site
582744004339	active site
582744004340	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
582744004341	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582744004342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
582744004343	motif II; other site
582744004344	DNA repair protein RadA; Provisional; Region: PRK11823
582744004345	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
582744004346	Walker A motif/ATP binding site; other site
582744004347	ATP binding site [chemical binding]; other site
582744004348	Walker B motif; other site
582744004349	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
582744004350	alanine racemase; Reviewed; Region: alr; PRK00053
582744004351	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
582744004352	active site
582744004353	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582744004354	substrate binding site [chemical binding]; other site
582744004355	catalytic residues [active]
582744004356	dimer interface [polypeptide binding]; other site
582744004357	replicative DNA helicase; Region: DnaB; TIGR00665
582744004358	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
582744004359	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
582744004360	Walker A motif; other site
582744004361	ATP binding site [chemical binding]; other site
582744004362	Walker B motif; other site
582744004363	DNA binding loops [nucleotide binding]
582744004364	cystathionine beta-lyase; Provisional; Region: PRK07050
582744004365	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582744004366	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744004367	catalytic residue [active]
582744004368	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
582744004369	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
582744004370	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
582744004371	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
582744004372	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
582744004373	dimer interface [polypeptide binding]; other site
582744004374	ssDNA binding site [nucleotide binding]; other site
582744004375	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582744004376	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
582744004377	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
582744004378	Phosphoenolpyruvate carboxylase [Carbohydrate transport and    metabolism; Energy production and conversion]; Region: COG1892; cl14656
582744004379	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
582744004380	glycogen synthase; Provisional; Region: glgA; PRK00654
582744004381	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
582744004382	ADP-binding pocket [chemical binding]; other site
582744004383	homodimer interface [polypeptide binding]; other site
582744004384	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
582744004385	putative active site [active]
582744004386	putative substrate binding site [chemical binding]; other site
582744004387	catalytic site [active]
582744004388	dimer interface [polypeptide binding]; other site
582744004389	Peptidase family M48; Region: Peptidase_M48; cl12018
582744004390	GTPase RsgA; Reviewed; Region: PRK00098
582744004391	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
582744004392	GTPase/OB domain interface [polypeptide binding]; other site
582744004393	GTPase/Zn-binding domain interface [polypeptide binding]; other site
582744004394	GTP/Mg2+ binding site [chemical binding]; other site
582744004395	G4 box; other site
582744004396	G5 box; other site
582744004397	G1 box; other site
582744004398	Switch I region; other site
582744004399	G2 box; other site
582744004400	G3 box; other site
582744004401	Switch II region; other site
582744004402	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
582744004403	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
582744004404	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
582744004405	active site
582744004406	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
582744004407	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
582744004408	NADP binding site [chemical binding]; other site
582744004409	active site
582744004410	putative substrate binding site [chemical binding]; other site
582744004411	Cupin domain; Region: Cupin_2; cl09118
582744004412	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
582744004413	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
582744004414	substrate binding site [chemical binding]; other site
582744004415	tetramer interface [polypeptide binding]; other site
582744004416	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
582744004417	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
582744004418	NAD binding site [chemical binding]; other site
582744004419	substrate binding site [chemical binding]; other site
582744004420	homodimer interface [polypeptide binding]; other site
582744004421	active site
582744004422	Proteobacterial; Region: dnaQ_proteo; TIGR01406
582744004423	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
582744004424	active site
582744004425	substrate binding site [chemical binding]; other site
582744004426	catalytic site [active]
582744004427	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
582744004428	RNA/DNA hybrid binding site [nucleotide binding]; other site
582744004429	active site
582744004430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744004431	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744004432	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
582744004433	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582744004434	catalytic residue [active]
582744004435	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
582744004436	putative peptidoglycan binding site; other site
582744004437	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
582744004438	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
582744004439	putative peptidoglycan binding site; other site
582744004440	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
582744004441	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
582744004442	peptide binding site [polypeptide binding]; other site
582744004443	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
582744004444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744004445	dimer interface [polypeptide binding]; other site
582744004446	conserved gate region; other site
582744004447	putative PBP binding loops; other site
582744004448	ABC-ATPase subunit interface; other site
582744004449	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
582744004450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744004451	dimer interface [polypeptide binding]; other site
582744004452	conserved gate region; other site
582744004453	putative PBP binding loops; other site
582744004454	ABC-ATPase subunit interface; other site
582744004455	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
582744004456	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
582744004457	NAD binding site [chemical binding]; other site
582744004458	homotetramer interface [polypeptide binding]; other site
582744004459	homodimer interface [polypeptide binding]; other site
582744004460	substrate binding site [chemical binding]; other site
582744004461	active site
582744004462	periplasmic folding chaperone; Provisional; Region: PRK10788
582744004463	PPIC-type PPIASE domain; Region: Rotamase; cl08278
582744004464	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
582744004465	IHF dimer interface [polypeptide binding]; other site
582744004466	IHF - DNA interface [nucleotide binding]; other site
582744004467	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
582744004468	Found in ATP-dependent protease La (LON); Region: LON; cl01056
582744004469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744004470	Walker A motif; other site
582744004471	ATP binding site [chemical binding]; other site
582744004472	Walker B motif; other site
582744004473	arginine finger; other site
582744004474	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
582744004475	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
582744004476	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
582744004477	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744004478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744004479	Walker A motif; other site
582744004480	ATP binding site [chemical binding]; other site
582744004481	Walker B motif; other site
582744004482	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
582744004483	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
582744004484	oligomer interface [polypeptide binding]; other site
582744004485	active site residues [active]
582744004486	trigger factor; Provisional; Region: tig; PRK01490
582744004487	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
582744004488	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
582744004489	Phage integrase family; Region: Phage_integrase; pfam00589
582744004490	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582744004491	DNA binding site [nucleotide binding]
582744004492	Int/Topo IB signature motif; other site
582744004493	active site
582744004494	cell division protein DedD; Provisional; Region: PRK11633
582744004495	putative transposase OrfB; Reviewed; Region: PHA02517
582744004496	Integrase core domain; Region: rve; cl01316
582744004497	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
582744004498	hypothetical protein; Region: PHA01733
582744004499	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
582744004500	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
582744004501	BRO family, N-terminal domain; Region: Bro-N; pfam02498
582744004502	multiple promoter invertase; Provisional; Region: mpi; PRK13413
582744004503	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
582744004504	catalytic residues [active]
582744004505	catalytic nucleophile [active]
582744004506	Presynaptic Site I dimer interface [polypeptide binding]; other site
582744004507	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
582744004508	Synaptic Flat tetramer interface [polypeptide binding]; other site
582744004509	Synaptic Site I dimer interface [polypeptide binding]; other site
582744004510	DNA binding site [nucleotide binding]
582744004511	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
582744004512	DNA-binding interface [nucleotide binding]; DNA binding site
582744004513	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
582744004514	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
582744004515	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
582744004516	active site
582744004517	DNA binding site [nucleotide binding]
582744004518	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
582744004519	Catalytic site [active]
582744004520	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
582744004521	Outer membrane efflux protein; Region: OEP; pfam02321
582744004522	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582744004523	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582744004524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744004525	metal binding site [ion binding]; metal-binding site
582744004526	active site
582744004527	I-site; other site
582744004528	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
582744004529	aromatic arch; other site
582744004530	DCoH dimer interaction site [polypeptide binding]; other site
582744004531	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
582744004532	DCoH tetramer interaction site [polypeptide binding]; other site
582744004533	substrate binding site [chemical binding]; other site
582744004534	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
582744004535	substrate binding site [chemical binding]; other site
582744004536	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
582744004537	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
582744004538	chorismate binding enzyme; Region: Chorismate_bind; cl10555
582744004539	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
582744004540	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
582744004541	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744004542	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
582744004543	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
582744004544	active site
582744004545	Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774
582744004546	Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774
582744004547	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
582744004548	tetramer interface [polypeptide binding]; other site
582744004549	active site
582744004550	transaldolase-like protein; Provisional; Region: PTZ00411
582744004551	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
582744004552	active site
582744004553	dimer interface [polypeptide binding]; other site
582744004554	catalytic residue [active]
582744004555	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
582744004556	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
582744004557	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744004558	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5)...; Region: MCH; cd00545
582744004559	trimer interface I [polypeptide binding]; other site
582744004560	putative substrate binding pocket [chemical binding]; other site
582744004561	trimer interface II [polypeptide binding]; other site
582744004562	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
582744004563	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744004564	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
582744004565	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744004566	NAD(P) binding pocket [chemical binding]; other site
582744004567	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
582744004568	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
582744004569	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
582744004570	The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761
582744004571	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
582744004572	putative [4Fe-4S] binding site [ion binding]; other site
582744004573	putative molybdopterin cofactor binding site [chemical binding]; other site
582744004574	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
582744004575	Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304
582744004576	active site
582744004577	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
582744004578	lobe; Region: FTR; pfam01913
582744004579	FTR, proximal lobe; Region: FTR_C; pfam02741
582744004580	FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980
582744004581	putative subunit interface; other site
582744004582	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582744004583	ligand binding site [chemical binding]; other site
582744004584	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
582744004585	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
582744004586	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
582744004587	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744004588	Domain of unknown function DUF302; Region: DUF302; cl01364
582744004589	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
582744004590	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744004591	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
582744004592	substrate binding site [chemical binding]; other site
582744004593	dimerization interface [polypeptide binding]; other site
582744004594	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
582744004595	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
582744004596	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582744004597	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
582744004598	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
582744004599	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
582744004600	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
582744004601	Active Sites [active]
582744004602	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
582744004603	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
582744004604	Active Sites [active]
582744004605	sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034
582744004606	CysN_ATPS subfamily.  CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes.  ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate.  CysD, which...; Region: CysN_ATPS; cd04166
582744004607	CysD dimerization site [polypeptide binding]; other site
582744004608	G1 box; other site
582744004609	putative GEF interaction site [polypeptide binding]; other site
582744004610	GTP/Mg2+ binding site [chemical binding]; other site
582744004611	Switch I region; other site
582744004612	G2 box; other site
582744004613	G3 box; other site
582744004614	Switch II region; other site
582744004615	G4 box; other site
582744004616	G5 box; other site
582744004617	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695
582744004618	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095
582744004619	Ferredoxin [Energy production and conversion]; Region: COG1146
582744004620	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
582744004621	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
582744004622	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582744004623	ATP binding site [chemical binding]; other site
582744004624	putative Mg++ binding site [ion binding]; other site
582744004625	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744004626	nucleotide binding region [chemical binding]; other site
582744004627	ATP-binding site [chemical binding]; other site
582744004628	RQC domain; Region: RQC; pfam09382
582744004629	HRDC domain; Region: HRDC; cl02578
582744004630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744004631	putative substrate translocation pore; other site
582744004632	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582744004633	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
582744004634	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744004635	FeS/SAM binding site; other site
582744004636	radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085
582744004637	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
582744004638	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
582744004639	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744004640	coenzyme PQQ biosynthesis protein A; Provisional; Region: PRK14763
582744004641	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
582744004642	NeuB family; Region: NeuB; cl00496
582744004643	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
582744004644	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744004645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744004646	homodimer interface [polypeptide binding]; other site
582744004647	catalytic residue [active]
582744004648	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744004649	metal binding site [ion binding]; metal-binding site
582744004650	active site
582744004651	I-site; other site
582744004652	Chorismate mutase type II; Region: CM_2; cl00693
582744004653	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
582744004654	Prephenate dehydratase; Region: PDT; pfam00800
582744004655	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
582744004656	putative L-Phe binding site [chemical binding]; other site
582744004657	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active...; Region: PSAT_like; cd00611
582744004658	homodimer interface [polypeptide binding]; other site
582744004659	substrate-cofactor binding pocket; other site
582744004660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744004661	catalytic residue [active]
582744004662	DNA gyrase subunit A; Validated; Region: PRK05560
582744004663	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
582744004664	CAP-like domain; other site
582744004665	Active site [active]
582744004666	primary dimer interface [polypeptide binding]; other site
582744004667	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582744004668	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582744004669	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582744004670	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582744004671	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582744004672	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
582744004673	peroxidase; Provisional; Region: PRK15000
582744004674	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015
582744004675	dimer interface [polypeptide binding]; other site
582744004676	decamer (pentamer of dimers) interface [polypeptide binding]; other site
582744004677	catalytic triad [active]
582744004678	peroxidatic and resolving cysteines [active]
582744004679	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
582744004680	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
582744004681	homodimer interface [polypeptide binding]; other site
582744004682	substrate-cofactor binding pocket; other site
582744004683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744004684	catalytic residue [active]
582744004685	amidophosphoribosyltransferase; Provisional; Region: PRK09246
582744004686	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
582744004687	active site
582744004688	tetramer interface [polypeptide binding]; other site
582744004689	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
582744004690	Colicin V production protein; Region: Colicin_V; cl00567
582744004691	rare lipoprotein A; Provisional; Region: PRK10672
582744004692	Sporulation related domain; Region: SPOR; cl10051
582744004693	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
582744004694	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
582744004695	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
582744004696	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
582744004697	substrate binding site [chemical binding]; other site
582744004698	active site
582744004699	catalytic residues [active]
582744004700	heterodimer interface [polypeptide binding]; other site
582744004701	tryptophan synthase, beta chain; Region: PLN02618
582744004702	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
582744004703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744004704	catalytic residue [active]
582744004705	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405
582744004706	active site
582744004707	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
582744004708	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
582744004709	dimerization interface 3.5A [polypeptide binding]; other site
582744004710	active site
582744004711	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
582744004712	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
582744004713	FimV N-terminal domain; Region: FimV_core; TIGR03505
582744004714	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
582744004715	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
582744004716	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744004717	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
582744004718	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
582744004719	isocitrate dehydrogenase; Validated; Region: PRK06451
582744004720	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
582744004721	substrate binding site [chemical binding]; other site
582744004722	Entericidin EcnA/B family; Region: Entericidin; cl02322
582744004723	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
582744004724	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
582744004725	substrate binding site [chemical binding]; other site
582744004726	ligand binding site [chemical binding]; other site
582744004727	Protein of unknown function (DUF520); Region: DUF520; cl00723
582744004728	DinB superfamily; Region: DinB_2; cl00986
582744004729	Protein of unknown function (DUF1255); Region: DUF1255; cl01202
582744004730	argininosuccinate synthase; Provisional; Region: PLN00200
582744004731	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
582744004732	ANP binding site [chemical binding]; other site
582744004733	Substrate Binding Site II [chemical binding]; other site
582744004734	Substrate Binding Site I [chemical binding]; other site
582744004735	ornithine carbamoyltransferase; Provisional; Region: PRK00779
582744004736	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
582744004737	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
582744004738	acetylornithine aminotransferase; Provisional; Region: PRK02627
582744004739	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
582744004740	inhibitor-cofactor binding pocket; inhibition site
582744004741	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744004742	catalytic residue [active]
582744004743	Predicted membrane protein [Function unknown]; Region: COG3748
582744004744	Protein of unknown function (DUF989); Region: DUF989; pfam06181
582744004745	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
582744004746	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
582744004747	[2Fe-2S] cluster binding site [ion binding]; other site
582744004748	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
582744004749	alpha subunit interface [polypeptide binding]; other site
582744004750	active site
582744004751	substrate binding site [chemical binding]; other site
582744004752	Fe binding site [ion binding]; other site
582744004753	EamA-like transporter family; Region: EamA; cl01037
582744004754	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
582744004755	response regulator; Provisional; Region: PRK09483
582744004756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744004757	active site
582744004758	phosphorylation site [posttranslational modification]
582744004759	intermolecular recognition site; other site
582744004760	dimerization interface [polypeptide binding]; other site
582744004761	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744004762	DNA binding residues [nucleotide binding]
582744004763	dimerization interface [polypeptide binding]; other site
582744004764	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744004765	PAS domain S-box; Region: sensory_box; TIGR00229
582744004766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744004767	putative active site [active]
582744004768	heme pocket [chemical binding]; other site
582744004769	Histidine kinase; Region: HisKA_3; pfam07730
582744004770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744004771	ATP binding site [chemical binding]; other site
582744004772	Mg2+ binding site [ion binding]; other site
582744004773	G-X-G motif; other site
582744004774	Cache domain; Region: Cache_1; pfam02743
582744004775	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744004776	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744004777	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744004778	HPP family; Region: HPP; pfam04982
582744004779	Integral membrane protein TerC family; Region: TerC; cl10468
582744004780	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
582744004781	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582744004782	metal binding triad; other site
582744004783	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
582744004784	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
582744004785	metal binding triad; other site
582744004786	acetyl-CoA synthetase; Provisional; Region: PRK00174
582744004787	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
582744004788	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
582744004789	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
582744004790	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
582744004791	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744004792	N-terminal plug; other site
582744004793	ligand-binding site [chemical binding]; other site
582744004794	fec operon regulator FecR; Reviewed; Region: PRK09774
582744004795	FecR protein; Region: FecR; pfam04773
582744004796	RNA polymerase sigma factor; Provisional; Region: PRK12528
582744004797	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744004798	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744004799	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053
582744004800	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582744004801	dimerization interface [polypeptide binding]; other site
582744004802	putative DNA binding site [nucleotide binding]; other site
582744004803	putative Zn2+ binding site [ion binding]; other site
582744004804	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744004805	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
582744004806	RF3 subfamily.  Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria.  Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
582744004807	G1 box; other site
582744004808	putative GEF interaction site [polypeptide binding]; other site
582744004809	GTP/Mg2+ binding site [chemical binding]; other site
582744004810	Switch I region; other site
582744004811	G2 box; other site
582744004812	G3 box; other site
582744004813	Switch II region; other site
582744004814	G4 box; other site
582744004815	G5 box; other site
582744004816	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
582744004817	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582744004818	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582744004819	ligand binding site [chemical binding]; other site
582744004820	flexible hinge region; other site
582744004821	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744004822	Response regulator receiver domain; Region: Response_reg; pfam00072
582744004823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744004824	active site
582744004825	phosphorylation site [posttranslational modification]
582744004826	intermolecular recognition site; other site
582744004827	dimerization interface [polypeptide binding]; other site
582744004828	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
582744004829	GAF domain; Region: GAF; cl00853
582744004830	Phytochrome region; Region: PHY; pfam00360
582744004831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744004832	dimer interface [polypeptide binding]; other site
582744004833	phosphorylation site [posttranslational modification]
582744004834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744004835	ATP binding site [chemical binding]; other site
582744004836	Mg2+ binding site [ion binding]; other site
582744004837	G-X-G motif; other site
582744004838	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
582744004839	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
582744004840	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744004841	substrate binding pocket [chemical binding]; other site
582744004842	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
582744004843	Membrane bound L-sorbosone dehydrogenase; Region: SNDH; pfam12303
582744004844	CHASE domain; Region: CHASE; cl01369
582744004845	PAS fold; Region: PAS_3; pfam08447
582744004846	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
582744004847	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744004848	metal binding site [ion binding]; metal-binding site
582744004849	active site
582744004850	I-site; other site
582744004851	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744004852	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582744004853	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582744004854	DNA-binding site [nucleotide binding]; DNA binding site
582744004855	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744004856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744004857	homodimer interface [polypeptide binding]; other site
582744004858	catalytic residue [active]
582744004859	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
582744004860	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
582744004861	putative molybdopterin cofactor binding site [chemical binding]; other site
582744004862	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787
582744004863	putative molybdopterin cofactor binding site; other site
582744004864	Phosphotransferase enzyme family; Region: APH; pfam01636
582744004865	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
582744004866	active site
582744004867	ATP binding site [chemical binding]; other site
582744004868	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340
582744004869	catalytic residues [active]
582744004870	dimer interface [polypeptide binding]; other site
582744004871	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582744004872	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
582744004873	Uncharacterised ACR, COG2135; Region: DUF159; cl03646
582744004874	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
582744004875	Catalytic site [active]
582744004876	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
582744004877	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
582744004878	active site
582744004879	DNA binding site [nucleotide binding]
582744004880	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
582744004881	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
582744004882	Phage-related minor tail protein [Function unknown]; Region: COG5281
582744004883	Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192
582744004884	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
582744004885	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
582744004886	HeH/LEM domain; Region: HeH; pfam12949
582744004887	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
582744004888	Phage terminase large subunit; Region: Terminase_3; cl12054
582744004889	Terminase-like family; Region: Terminase_6; pfam03237
582744004890	Endodeoxyribonuclease RusA; Region: RusA; cl01885
582744004891	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
582744004892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582744004893	non-specific DNA binding site [nucleotide binding]; other site
582744004894	salt bridge; other site
582744004895	sequence-specific DNA binding site [nucleotide binding]; other site
582744004896	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
582744004897	Catalytic site [active]
582744004898	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
582744004899	Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377
582744004900	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
582744004901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744004902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744004903	cofactor binding site; other site
582744004904	DNA binding site [nucleotide binding]
582744004905	substrate interaction site [chemical binding]; other site
582744004906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744004907	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
582744004908	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542
582744004909	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
582744004910	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
582744004911	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
582744004912	Phage integrase family; Region: Phage_integrase; pfam00589
582744004913	active site
582744004914	Int/Topo IB signature motif; other site
582744004915	cyclase homology domain; Region: CHD; cd07302
582744004916	nucleotidyl binding site; other site
582744004917	metal binding site [ion binding]; metal-binding site
582744004918	dimer interface [polypeptide binding]; other site
582744004919	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
582744004920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744004921	Walker A motif; other site
582744004922	ATP binding site [chemical binding]; other site
582744004923	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744004924	Walker B motif; other site
582744004925	arginine finger; other site
582744004926	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
582744004927	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969
582744004928	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
582744004929	recombination protein RecR; Reviewed; Region: recR; PRK00076
582744004930	RecR protein; Region: RecR; pfam02132
582744004931	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
582744004932	putative active site [active]
582744004933	putative metal-binding site [ion binding]; other site
582744004934	tetramer interface [polypeptide binding]; other site
582744004935	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582744004936	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
582744004937	motif II; other site
582744004938	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
582744004939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744004940	S-adenosylmethionine binding site [chemical binding]; other site
582744004941	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
582744004942	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
582744004943	active site
582744004944	putative substrate binding pocket [chemical binding]; other site
582744004945	OprF membrane domain; Region: OprF; pfam05736
582744004946	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582744004947	ligand binding site [chemical binding]; other site
582744004948	Protein of unknown function (DUF556); Region: DUF556; cl00822
582744004949	Protein of unknown function (DUF447); Region: DUF447; cl01035
582744004950	dihydropteroate synthase-related protein; Region: TIGR00284
582744004951	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
582744004952	substrate binding pocket [chemical binding]; other site
582744004953	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
582744004954	dimer interface [polypeptide binding]; other site
582744004955	inhibitor binding site; inhibition site
582744004956	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
582744004957	Flavoprotein; Region: Flavoprotein; cl08021
582744004958	adenylosuccinate synthetase; Provisional; Region: PRK01117
582744004959	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
582744004960	GDP-binding site [chemical binding]; other site
582744004961	ACT binding site; other site
582744004962	IMP binding site; other site
582744004963	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
582744004964	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
582744004965	dimer interface [polypeptide binding]; other site
582744004966	motif 1; other site
582744004967	active site
582744004968	motif 2; other site
582744004969	motif 3; other site
582744004970	FtsH protease regulator HflC; Provisional; Region: PRK11029
582744004971	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
582744004972	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
582744004973	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
582744004974	HflK protein; Region: hflK; TIGR01933
582744004975	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
582744004976	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
582744004977	G1 box; other site
582744004978	GTP/Mg2+ binding site [chemical binding]; other site
582744004979	Switch I region; other site
582744004980	G2 box; other site
582744004981	G3 box; other site
582744004982	Switch II region; other site
582744004983	G4 box; other site
582744004984	G5 box; other site
582744004985	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
582744004986	Sm1 motif; other site
582744004987	intra - hexamer interaction site; other site
582744004988	inter - hexamer interaction site [polypeptide binding]; other site
582744004989	nucleotide binding pocket [chemical binding]; other site
582744004990	Sm2 motif; other site
582744004991	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
582744004992	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582744004993	active site
582744004994	HIGH motif; other site
582744004995	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
582744004996	active site
582744004997	KMSKS motif; other site
582744004998	NodT family; Region: outer_NodT; TIGR01845
582744004999	Outer membrane efflux protein; Region: OEP; pfam02321
582744005000	Outer membrane efflux protein; Region: OEP; pfam02321
582744005001	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
582744005002	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582744005003	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
582744005004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744005005	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
582744005006	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582744005007	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744005008	putative active site [active]
582744005009	heme pocket [chemical binding]; other site
582744005010	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744005011	putative active site [active]
582744005012	heme pocket [chemical binding]; other site
582744005013	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744005014	metal binding site [ion binding]; metal-binding site
582744005015	active site
582744005016	I-site; other site
582744005017	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744005018	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
582744005019	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582744005020	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744005021	FeS/SAM binding site; other site
582744005022	TRAM domain; Region: TRAM; cl01282
582744005023	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
582744005024	ZIP Zinc transporter; Region: Zip; pfam02535
582744005025	PEP-CTERM motif; Region: VPEP; pfam07589
582744005026	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
582744005027	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744005028	N-terminal plug; other site
582744005029	ligand-binding site [chemical binding]; other site
582744005030	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
582744005031	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
582744005032	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
582744005033	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582744005034	RNA binding surface [nucleotide binding]; other site
582744005035	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
582744005036	active site
582744005037	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
582744005038	GTP-binding protein Der; Reviewed; Region: PRK00093
582744005039	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
582744005040	G1 box; other site
582744005041	GTP/Mg2+ binding site [chemical binding]; other site
582744005042	Switch I region; other site
582744005043	G2 box; other site
582744005044	Switch II region; other site
582744005045	G3 box; other site
582744005046	G4 box; other site
582744005047	G5 box; other site
582744005048	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
582744005049	G1 box; other site
582744005050	GTP/Mg2+ binding site [chemical binding]; other site
582744005051	Switch I region; other site
582744005052	G2 box; other site
582744005053	G3 box; other site
582744005054	Switch II region; other site
582744005055	G4 box; other site
582744005056	G5 box; other site
582744005057	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
582744005058	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
582744005059	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
582744005060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
582744005061	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
582744005062	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
582744005063	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
582744005064	Walker A/P-loop; other site
582744005065	ATP binding site [chemical binding]; other site
582744005066	Q-loop/lid; other site
582744005067	ABC transporter signature motif; other site
582744005068	Walker B; other site
582744005069	D-loop; other site
582744005070	H-loop/switch region; other site
582744005071	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
582744005072	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
582744005073	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
582744005074	Walker A/P-loop; other site
582744005075	ATP binding site [chemical binding]; other site
582744005076	Q-loop/lid; other site
582744005077	ABC transporter signature motif; other site
582744005078	Walker B; other site
582744005079	D-loop; other site
582744005080	H-loop/switch region; other site
582744005081	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
582744005082	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
582744005083	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
582744005084	dimer interface [polypeptide binding]; other site
582744005085	motif 1; other site
582744005086	active site
582744005087	motif 2; other site
582744005088	motif 3; other site
582744005089	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
582744005090	anticodon binding site; other site
582744005091	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
582744005092	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
582744005093	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
582744005094	cytoskeletal protein RodZ; Provisional; Region: PRK10856
582744005095	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
582744005096	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744005097	binding surface
582744005098	TPR motif; other site
582744005099	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
582744005100	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744005101	FeS/SAM binding site; other site
582744005102	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
582744005103	active site
582744005104	multimer interface [polypeptide binding]; other site
582744005105	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
582744005106	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
582744005107	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
582744005108	ribonuclease R; Region: RNase_R; TIGR02063
582744005109	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
582744005110	RNB domain; Region: RNB; pfam00773
582744005111	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
582744005112	RNA binding site [nucleotide binding]; other site
582744005113	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
582744005114	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
582744005115	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
582744005116	NAD(P) binding site [chemical binding]; other site
582744005117	homodimer interface [polypeptide binding]; other site
582744005118	substrate binding site [chemical binding]; other site
582744005119	active site
582744005120	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
582744005121	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744005122	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
582744005123	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
582744005124	tropinone reductase; Provisional; Region: PRK09242
582744005125	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
582744005126	NADP binding site [chemical binding]; other site
582744005127	homodimer interface [polypeptide binding]; other site
582744005128	active site
582744005129	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
582744005130	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744005131	FeS/SAM binding site; other site
582744005132	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582744005133	RNA binding surface [nucleotide binding]; other site
582744005134	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
582744005135	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
582744005136	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
582744005137	MoaE homodimer interface [polypeptide binding]; other site
582744005138	MoaD interaction [polypeptide binding]; other site
582744005139	active site residues [active]
582744005140	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
582744005141	MoaE interaction surface [polypeptide binding]; other site
582744005142	MoeB interaction surface [polypeptide binding]; other site
582744005143	thiocarboxylated glycine; other site
582744005144	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
582744005145	RmuC family; Region: RmuC; pfam02646
582744005146	CHASE2 domain; Region: CHASE2; cl01732
582744005147	Bacterial SH3 domain; Region: SH3_3; cl02551
582744005148	Peptidase family M48; Region: Peptidase_M48; cl12018
582744005149	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
582744005150	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
582744005151	G1 box; other site
582744005152	putative GEF interaction site [polypeptide binding]; other site
582744005153	GTP/Mg2+ binding site [chemical binding]; other site
582744005154	Switch I region; other site
582744005155	G2 box; other site
582744005156	G3 box; other site
582744005157	Switch II region; other site
582744005158	G4 box; other site
582744005159	G5 box; other site
582744005160	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
582744005161	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a...; Region: BipA_TypA_C; cd03710
582744005162	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
582744005163	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
582744005164	ATP binding site [chemical binding]; other site
582744005165	Mg++ binding site [ion binding]; other site
582744005166	motif III; other site
582744005167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744005168	nucleotide binding region [chemical binding]; other site
582744005169	ATP-binding site [chemical binding]; other site
582744005170	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
582744005171	DEAD-like helicases superfamily; Region: DEXDc; smart00487
582744005172	ATP binding site [chemical binding]; other site
582744005173	Mg++ binding site [ion binding]; other site
582744005174	motif III; other site
582744005175	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
582744005176	nucleotide binding region [chemical binding]; other site
582744005177	ATP-binding site [chemical binding]; other site
582744005178	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454
582744005179	apolar tunnel; other site
582744005180	heme binding site [chemical binding]; other site
582744005181	dimerization interface [polypeptide binding]; other site
582744005182	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
582744005183	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744005184	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744005185	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582744005186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744005187	active site
582744005188	phosphorylation site [posttranslational modification]
582744005189	intermolecular recognition site; other site
582744005190	dimerization interface [polypeptide binding]; other site
582744005191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744005192	Walker A motif; other site
582744005193	ATP binding site [chemical binding]; other site
582744005194	Walker B motif; other site
582744005195	arginine finger; other site
582744005196	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744005197	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744005198	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744005199	N-terminal plug; other site
582744005200	ligand-binding site [chemical binding]; other site
582744005201	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
582744005202	FtsX-like permease family; Region: FtsX; pfam02687
582744005203	FtsX-like permease family; Region: FtsX; pfam02687
582744005204	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
582744005205	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
582744005206	Walker A/P-loop; other site
582744005207	ATP binding site [chemical binding]; other site
582744005208	Q-loop/lid; other site
582744005209	ABC transporter signature motif; other site
582744005210	Walker B; other site
582744005211	D-loop; other site
582744005212	H-loop/switch region; other site
582744005213	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
582744005214	active site
582744005215	catalytic triad [active]
582744005216	oxyanion hole [active]
582744005217	switch loop; other site
582744005218	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
582744005219	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
582744005220	Ligand Binding Site [chemical binding]; other site
582744005221	B3/4 domain; Region: B3_4; cl11458
582744005222	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
582744005223	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
582744005224	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
582744005225	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
582744005226	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
582744005227	generic binding surface II; other site
582744005228	generic binding surface I; other site
582744005229	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
582744005230	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
582744005231	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
582744005232	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
582744005233	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
582744005234	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
582744005235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744005236	ATP binding site [chemical binding]; other site
582744005237	Mg2+ binding site [ion binding]; other site
582744005238	G-X-G motif; other site
582744005239	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
582744005240	Response regulator receiver domain; Region: Response_reg; pfam00072
582744005241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744005242	active site
582744005243	phosphorylation site [posttranslational modification]
582744005244	intermolecular recognition site; other site
582744005245	dimerization interface [polypeptide binding]; other site
582744005246	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744005247	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744005248	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
582744005249	Response regulator receiver domain; Region: Response_reg; pfam00072
582744005250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744005251	active site
582744005252	phosphorylation site [posttranslational modification]
582744005253	intermolecular recognition site; other site
582744005254	dimerization interface [polypeptide binding]; other site
582744005255	Response regulator receiver domain; Region: Response_reg; pfam00072
582744005256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744005257	active site
582744005258	phosphorylation site [posttranslational modification]
582744005259	intermolecular recognition site; other site
582744005260	dimerization interface [polypeptide binding]; other site
582744005261	Uncharacterized conserved protein [Function unknown]; Region: COG3287
582744005262	FIST N domain; Region: FIST; pfam08495
582744005263	FIST C domain; Region: FIST_C; pfam10442
582744005264	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
582744005265	dimer interface [polypeptide binding]; other site
582744005266	catalytic triad [active]
582744005267	peroxidatic and resolving cysteines [active]
582744005268	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
582744005269	homodimer interface [polypeptide binding]; other site
582744005270	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
582744005271	active site pocket [active]
582744005272	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
582744005273	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
582744005274	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582744005275	Gram-negative bacterial tonB protein; Region: TonB; cl10048
582744005276	Hemin uptake protein hemP; Region: hemP; cl10043
582744005277	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
582744005278	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
582744005279	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582744005280	RNA binding surface [nucleotide binding]; other site
582744005281	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
582744005282	heat shock protein 90; Provisional; Region: PRK05218
582744005283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
582744005284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582744005285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744005286	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
582744005287	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
582744005288	active site
582744005289	non-prolyl cis peptide bond; other site
582744005290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744005291	D-galactonate transporter; Region: 2A0114; TIGR00893
582744005292	putative substrate translocation pore; other site
582744005293	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
582744005294	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744005295	N-terminal plug; other site
582744005296	ligand-binding site [chemical binding]; other site
582744005297	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792
582744005298	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755
582744005299	putative ATP binding site [chemical binding]; other site
582744005300	putative substrate interface [chemical binding]; other site
582744005301	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
582744005302	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
582744005303	active site
582744005304	hydrophilic channel; other site
582744005305	dimerization interface [polypeptide binding]; other site
582744005306	catalytic residues [active]
582744005307	active site lid [active]
582744005308	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
582744005309	Recombination protein O N terminal; Region: RecO_N; pfam11967
582744005310	Recombination protein O C terminal; Region: RecO_C; pfam02565
582744005311	GTPase Era; Reviewed; Region: era; PRK00089
582744005312	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
582744005313	G1 box; other site
582744005314	GTP/Mg2+ binding site [chemical binding]; other site
582744005315	Switch I region; other site
582744005316	G2 box; other site
582744005317	Switch II region; other site
582744005318	G3 box; other site
582744005319	G4 box; other site
582744005320	G5 box; other site
582744005321	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
582744005322	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
582744005323	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
582744005324	dimerization interface [polypeptide binding]; other site
582744005325	active site
582744005326	metal binding site [ion binding]; metal-binding site
582744005327	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
582744005328	dsRNA binding site [nucleotide binding]; other site
582744005329	signal peptidase I; Provisional; Region: PRK10861
582744005330	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
582744005331	Catalytic site [active]
582744005332	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
582744005333	GTP-binding protein LepA; Provisional; Region: PRK05433
582744005334	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
582744005335	G1 box; other site
582744005336	putative GEF interaction site [polypeptide binding]; other site
582744005337	GTP/Mg2+ binding site [chemical binding]; other site
582744005338	Switch I region; other site
582744005339	G2 box; other site
582744005340	G3 box; other site
582744005341	Switch II region; other site
582744005342	G4 box; other site
582744005343	G5 box; other site
582744005344	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
582744005345	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
582744005346	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
582744005347	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582744005348	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
582744005349	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
582744005350	protein binding site [polypeptide binding]; other site
582744005351	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
582744005352	protein binding site [polypeptide binding]; other site
582744005353	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
582744005354	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
582744005355	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
582744005356	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744005357	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
582744005358	DNA binding residues [nucleotide binding]
582744005359	L-aspartate oxidase; Provisional; Region: PRK09077
582744005360	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744005361	domain; Region: Succ_DH_flav_C; pfam02910
582744005362	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
582744005363	hypothetical protein; Provisional; Region: PRK05409
582744005364	Protein of unknown function (DUF692); Region: DUF692; cl01263
582744005365	RNA polymerase sigma factor; Provisional; Region: PRK12520
582744005366	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744005367	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744005368	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
582744005369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
582744005370	FIST C domain; Region: FIST_C; pfam10442
582744005371	endonuclease III; Provisional; Region: PRK10702
582744005372	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582744005373	minor groove reading motif; other site
582744005374	helix-hairpin-helix signature motif; other site
582744005375	substrate binding pocket [chemical binding]; other site
582744005376	active site
582744005377	FES domain; Region: FES; smart00525
582744005378	electron transport complex protein RnfB; Provisional; Region: PRK05113
582744005379	4Fe-4S binding domain; Region: Fer4; cl02805
582744005380	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
582744005381	dihydrodipicolinate synthase; Region: dapA; TIGR00674
582744005382	dimer interface [polypeptide binding]; other site
582744005383	active site
582744005384	catalytic residue [active]
582744005385	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
582744005386	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744005387	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582744005388	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
582744005389	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
582744005390	Cupin superfamily protein; Region: Cupin_4; pfam08007
582744005391	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
582744005392	catalytic triad [active]
582744005393	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
582744005394	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
582744005395	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
582744005396	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582744005397	active site
582744005398	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
582744005399	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406
582744005400	NAD(P) binding site [chemical binding]; other site
582744005401	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
582744005402	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
582744005403	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582744005404	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
582744005405	Trp docking motif; other site
582744005406	'Velcro' closure; other site
582744005407	active site
582744005408	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
582744005409	Acyltransferase family; Region: Acyl_transf_3; pfam01757
582744005410	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
582744005411	catalytic residues [active]
582744005412	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
582744005413	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
582744005414	MutS domain I; Region: MutS_I; pfam01624
582744005415	MutS domain II; Region: MutS_II; pfam05188
582744005416	MutS family domain IV; Region: MutS_IV; pfam05190
582744005417	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
582744005418	Walker A/P-loop; other site
582744005419	ATP binding site [chemical binding]; other site
582744005420	Q-loop/lid; other site
582744005421	ABC transporter signature motif; other site
582744005422	Walker B; other site
582744005423	D-loop; other site
582744005424	H-loop/switch region; other site
582744005425	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
582744005426	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582744005427	catalytic residue [active]
582744005428	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
582744005429	active site
582744005430	tetramer interface [polypeptide binding]; other site
582744005431	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
582744005432	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
582744005433	NAD binding site [chemical binding]; other site
582744005434	homodimer interface [polypeptide binding]; other site
582744005435	active site
582744005436	substrate binding site [chemical binding]; other site
582744005437	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
582744005438	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
582744005439	Substrate binding site [chemical binding]; other site
582744005440	Cupin domain; Region: Cupin_2; cl09118
582744005441	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
582744005442	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
582744005443	DXD motif; other site
582744005444	GtrA-like protein; Region: GtrA; cl00971
582744005445	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
582744005446	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
582744005447	putative ADP-binding pocket [chemical binding]; other site
582744005448	O-Antigen ligase; Region: Wzy_C; cl04850
582744005449	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
582744005450	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
582744005451	active site
582744005452	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
582744005453	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582744005454	active site
582744005455	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
582744005456	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
582744005457	eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495
582744005458	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
582744005459	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
582744005460	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744005461	chain length determinant protein EpsF; Region: EpsF; TIGR03017
582744005462	Chain length determinant protein; Region: Wzz; cl01623
582744005463	Chain length determinant protein; Region: Wzz; cl01623
582744005464	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
582744005465	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
582744005466	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
582744005467	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
582744005468	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051
582744005469	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582744005470	ligand binding site [chemical binding]; other site
582744005471	flexible hinge region; other site
582744005472	transcriptional regulator EpsA; Region: EpsA; TIGR03020
582744005473	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744005474	DNA binding residues [nucleotide binding]
582744005475	dimerization interface [polypeptide binding]; other site
582744005476	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
582744005477	Bacterial sugar transferase; Region: Bac_transf; cl00939
582744005478	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
582744005479	active site
582744005480	dimerization interface [polypeptide binding]; other site
582744005481	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
582744005482	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
582744005483	serine O-acetyltransferase; Region: cysE; TIGR01172
582744005484	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
582744005485	trimer interface [polypeptide binding]; other site
582744005486	active site
582744005487	substrate binding site [chemical binding]; other site
582744005488	CoA binding site [chemical binding]; other site
582744005489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744005490	Rrf2 family protein; Region: rrf2_super; TIGR00738
582744005491	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582744005492	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582744005493	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744005494	catalytic residue [active]
582744005495	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582744005496	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582744005497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744005498	catalytic residue [active]
582744005499	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
582744005500	trimerization site [polypeptide binding]; other site
582744005501	active site
582744005502	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
582744005503	co-chaperone HscB; Provisional; Region: hscB; PRK03578
582744005504	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542
582744005505	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
582744005506	chaperone protein HscA; Provisional; Region: hscA; PRK05183
582744005507	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582744005508	catalytic loop [active]
582744005509	iron binding site [ion binding]; other site
582744005510	putative diguanylate cyclase; Provisional; Region: PRK09776
582744005511	MASE1; Region: MASE1; pfam05231
582744005512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744005513	putative active site [active]
582744005514	heme pocket [chemical binding]; other site
582744005515	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744005516	putative active site [active]
582744005517	heme pocket [chemical binding]; other site
582744005518	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744005519	putative active site [active]
582744005520	heme pocket [chemical binding]; other site
582744005521	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744005522	metal binding site [ion binding]; metal-binding site
582744005523	active site
582744005524	I-site; other site
582744005525	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744005526	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
582744005527	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
582744005528	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
582744005529	dimer interface [polypeptide binding]; other site
582744005530	putative anticodon binding site; other site
582744005531	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
582744005532	motif 1; other site
582744005533	active site
582744005534	motif 2; other site
582744005535	motif 3; other site
582744005536	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744005537	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
582744005538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744005539	dimer interface [polypeptide binding]; other site
582744005540	conserved gate region; other site
582744005541	putative PBP binding loops; other site
582744005542	ABC-ATPase subunit interface; other site
582744005543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744005544	dimer interface [polypeptide binding]; other site
582744005545	conserved gate region; other site
582744005546	putative PBP binding loops; other site
582744005547	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
582744005548	ABC-ATPase subunit interface; other site
582744005549	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252
582744005550	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
582744005551	Walker A/P-loop; other site
582744005552	ATP binding site [chemical binding]; other site
582744005553	Q-loop/lid; other site
582744005554	ABC transporter signature motif; other site
582744005555	Walker B; other site
582744005556	D-loop; other site
582744005557	H-loop/switch region; other site
582744005558	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
582744005559	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
582744005560	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582744005561	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817
582744005562	putative ADP-binding pocket [chemical binding]; other site
582744005563	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
582744005564	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
582744005565	Cupin domain; Region: Cupin_2; cl09118
582744005566	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744005567	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
582744005568	active site
582744005569	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
582744005570	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
582744005571	active site
582744005572	substrate binding site [chemical binding]; other site
582744005573	metal binding site [ion binding]; metal-binding site
582744005574	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
582744005575	dihydropteroate synthase; Region: DHPS; TIGR01496
582744005576	substrate binding pocket [chemical binding]; other site
582744005577	dimer interface [polypeptide binding]; other site
582744005578	inhibitor binding site; inhibition site
582744005579	FtsH Extracellular; Region: FtsH_ext; pfam06480
582744005580	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
582744005581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744005582	Walker A motif; other site
582744005583	ATP binding site [chemical binding]; other site
582744005584	Walker B motif; other site
582744005585	arginine finger; other site
582744005586	Peptidase family M41; Region: Peptidase_M41; pfam01434
582744005587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744005588	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
582744005589	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
582744005590	domain; Region: GreA_GreB_N; pfam03449
582744005591	C-term; Region: GreA_GreB; pfam01272
582744005592	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
582744005593	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582744005594	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744005595	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
582744005596	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
582744005597	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744005598	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
582744005599	IMP binding site; other site
582744005600	dimer interface [polypeptide binding]; other site
582744005601	interdomain contacts; other site
582744005602	partial ornithine binding site; other site
582744005603	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
582744005604	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
582744005605	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
582744005606	catalytic site [active]
582744005607	subunit interface [polypeptide binding]; other site
582744005608	dihydrodipicolinate reductase; Provisional; Region: PRK00048
582744005609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744005610	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
582744005611	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
582744005612	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
582744005613	metal binding site 2 [ion binding]; metal-binding site
582744005614	putative DNA binding helix; other site
582744005615	metal binding site 1 [ion binding]; metal-binding site
582744005616	dimer interface [polypeptide binding]; other site
582744005617	structural Zn2+ binding site [ion binding]; other site
582744005618	recombination and repair protein; Provisional; Region: PRK10869
582744005619	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
582744005620	Walker A/P-loop; other site
582744005621	ATP binding site [chemical binding]; other site
582744005622	Q-loop/lid; other site
582744005623	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
582744005624	ABC transporter signature motif; other site
582744005625	Walker B; other site
582744005626	D-loop; other site
582744005627	H-loop/switch region; other site
582744005628	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
582744005629	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
582744005630	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
582744005631	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
582744005632	HrcA protein C terminal domain; Region: HrcA; pfam01628
582744005633	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
582744005634	Flagellar protein YcgR; Region: YcgR_2; pfam12945
582744005635	PilZ domain; Region: PilZ; cl01260
582744005636	ferrochelatase; Reviewed; Region: hemH; PRK00035
582744005637	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
582744005638	C-terminal domain interface [polypeptide binding]; other site
582744005639	active site
582744005640	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
582744005641	active site
582744005642	N-terminal domain interface [polypeptide binding]; other site
582744005643	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
582744005644	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
582744005645	NADP binding site [chemical binding]; other site
582744005646	homopentamer interface [polypeptide binding]; other site
582744005647	substrate binding site [chemical binding]; other site
582744005648	active site
582744005649	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
582744005650	dimer interface [polypeptide binding]; other site
582744005651	active site
582744005652	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
582744005653	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
582744005654	putative ribose interaction site [chemical binding]; other site
582744005655	putative ADP binding site [chemical binding]; other site
582744005656	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
582744005657	active site
582744005658	nucleotide binding site [chemical binding]; other site
582744005659	HIGH motif; other site
582744005660	KMSKS motif; other site
582744005661	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
582744005662	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
582744005663	putative active site [active]
582744005664	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582744005665	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
582744005666	putative ADP-binding pocket [chemical binding]; other site
582744005667	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
582744005668	active site
582744005669	ATP binding site [chemical binding]; other site
582744005670	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582744005671	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
582744005672	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
582744005673	active site
582744005674	intersubunit interface [polypeptide binding]; other site
582744005675	catalytic residue [active]
582744005676	Dehydratase family; Region: ILVD_EDD; cl00340
582744005677	6-phosphogluconate dehydratase; Region: edd; TIGR01196
582744005678	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
582744005679	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
582744005680	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
582744005681	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582744005682	active site
582744005683	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
582744005684	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
582744005685	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582744005686	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582744005687	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
582744005688	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
582744005689	putative active site [active]
582744005690	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
582744005691	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
582744005692	dimer interface [polypeptide binding]; other site
582744005693	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
582744005694	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
582744005695	chaperone protein DnaJ; Provisional; Region: PRK10767
582744005696	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
582744005697	HSP70 interaction site [polypeptide binding]; other site
582744005698	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
582744005699	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
582744005700	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
582744005701	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
582744005702	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
582744005703	putative active site [active]
582744005704	O-Antigen ligase; Region: Wzy_C; cl04850
582744005705	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
582744005706	putative active site [active]
582744005707	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582744005708	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
582744005709	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
582744005710	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
582744005711	putative ADP-binding pocket [chemical binding]; other site
582744005712	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
582744005713	Protein of unknown function (DUF1022); Region: DUF1022; pfam06258
582744005714	2-isopropylmalate synthase; Validated; Region: PRK03739
582744005715	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
582744005716	active site
582744005717	catalytic residues [active]
582744005718	metal binding site [ion binding]; metal-binding site
582744005719	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
582744005720	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744005721	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
582744005722	substrate binding pocket [chemical binding]; other site
582744005723	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744005724	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
582744005725	dimer interface [polypeptide binding]; other site
582744005726	active site
582744005727	metal binding site [ion binding]; metal-binding site
582744005728	glutathione binding site [chemical binding]; other site
582744005729	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744005730	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
582744005731	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
582744005732	substrate binding pocket [chemical binding]; other site
582744005733	membrane-bound complex binding site; other site
582744005734	hinge residues; other site
582744005735	hypothetical protein; Provisional; Region: PRK13795
582744005736	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
582744005737	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
582744005738	active site
582744005739	(T/H)XGH motif; other site
582744005740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744005741	S-adenosylmethionine binding site [chemical binding]; other site
582744005742	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582744005743	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582744005744	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582744005745	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
582744005746	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
582744005747	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
582744005748	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
582744005749	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
582744005750	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
582744005751	P loop; other site
582744005752	GTP binding site [chemical binding]; other site
582744005753	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
582744005754	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744005755	Walker A/P-loop; other site
582744005756	ATP binding site [chemical binding]; other site
582744005757	Q-loop/lid; other site
582744005758	ABC transporter signature motif; other site
582744005759	Walker B; other site
582744005760	D-loop; other site
582744005761	H-loop/switch region; other site
582744005762	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
582744005763	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
582744005764	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
582744005765	dimerization interface [polypeptide binding]; other site
582744005766	active site
582744005767	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
582744005768	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
582744005769	FAD binding pocket [chemical binding]; other site
582744005770	FAD binding motif [chemical binding]; other site
582744005771	phosphate binding motif [ion binding]; other site
582744005772	beta-alpha-beta structure motif; other site
582744005773	NAD binding pocket [chemical binding]; other site
582744005774	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
582744005775	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
582744005776	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
582744005777	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
582744005778	Ligand binding site [chemical binding]; other site
582744005779	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
582744005780	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
582744005781	putative dimerization interface [polypeptide binding]; other site
582744005782	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
582744005783	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744005784	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
582744005785	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
582744005786	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
582744005787	PhnA protein; Region: PhnA; pfam03831
582744005788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744005789	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
582744005790	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
582744005791	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
582744005792	homodimer interface [polypeptide binding]; other site
582744005793	substrate-cofactor binding pocket; other site
582744005794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744005795	catalytic residue [active]
582744005796	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
582744005797	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
582744005798	Walker A/P-loop; other site
582744005799	ATP binding site [chemical binding]; other site
582744005800	Q-loop/lid; other site
582744005801	ABC transporter signature motif; other site
582744005802	Walker B; other site
582744005803	D-loop; other site
582744005804	H-loop/switch region; other site
582744005805	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
582744005806	putative ligand binding site [chemical binding]; other site
582744005807	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
582744005808	TM-ABC transporter signature motif; other site
582744005809	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
582744005810	TM-ABC transporter signature motif; other site
582744005811	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
582744005812	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
582744005813	Walker A/P-loop; other site
582744005814	ATP binding site [chemical binding]; other site
582744005815	Q-loop/lid; other site
582744005816	ABC transporter signature motif; other site
582744005817	Walker B; other site
582744005818	D-loop; other site
582744005819	H-loop/switch region; other site
582744005820	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
582744005821	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
582744005822	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
582744005823	active site
582744005824	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
582744005825	dimer interface [polypeptide binding]; other site
582744005826	non-prolyl cis peptide bond; other site
582744005827	insertion regions; other site
582744005828	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
582744005829	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
582744005830	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
582744005831	Flavin binding site [chemical binding]; other site
582744005832	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582744005833	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744005834	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
582744005835	NodT family; Region: outer_NodT; TIGR01845
582744005836	Outer membrane efflux protein; Region: OEP; pfam02321
582744005837	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582744005838	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582744005839	Protein export membrane protein; Region: SecD_SecF; cl14618
582744005840	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
582744005841	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
582744005842	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
582744005843	active site
582744005844	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
582744005845	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
582744005846	active site
582744005847	dimer interface [polypeptide binding]; other site
582744005848	non-prolyl cis peptide bond; other site
582744005849	insertion regions; other site
582744005850	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
582744005851	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
582744005852	Flavin binding site [chemical binding]; other site
582744005853	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
582744005854	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744005855	Walker A motif; other site
582744005856	ATP binding site [chemical binding]; other site
582744005857	Walker B motif; other site
582744005858	arginine finger; other site
582744005859	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744005860	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
582744005861	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
582744005862	dimerization interface [polypeptide binding]; other site
582744005863	active site
582744005864	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
582744005865	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
582744005866	substrate binding pocket [chemical binding]; other site
582744005867	membrane-bound complex binding site; other site
582744005868	hinge residues; other site
582744005869	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744005870	metal binding site [ion binding]; metal-binding site
582744005871	active site
582744005872	I-site; other site
582744005873	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744005874	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
582744005875	active site
582744005876	nucleophile elbow; other site
582744005877	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744005878	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744005879	N-terminal plug; other site
582744005880	ligand-binding site [chemical binding]; other site
582744005881	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
582744005882	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744005883	putative substrate translocation pore; other site
582744005884	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
582744005885	hypothetical protein; Provisional; Region: PRK10649
582744005886	Sulfatase; Region: Sulfatase; cl10460
582744005887	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744005888	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
582744005889	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
582744005890	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582744005891	Coenzyme A binding pocket [chemical binding]; other site
582744005892	Protein of unknown function (DUF330); Region: DUF330; cl01135
582744005893	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
582744005894	mce related protein; Region: MCE; cl03606
582744005895	mce related protein; Region: MCE; cl03606
582744005896	mce related protein; Region: MCE; cl03606
582744005897	Paraquat-inducible protein A; Region: PqiA; pfam04403
582744005898	Paraquat-inducible protein A; Region: PqiA; pfam04403
582744005899	Autotransporter beta-domain; Region: Autotransporter; cl02365
582744005900	EamA-like transporter family; Region: EamA; cl01037
582744005901	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
582744005902	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
582744005903	intersubunit interface [polypeptide binding]; other site
582744005904	active site
582744005905	Zn2+ binding site [ion binding]; other site
582744005906	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
582744005907	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744005908	Walker A/P-loop; other site
582744005909	ATP binding site [chemical binding]; other site
582744005910	Q-loop/lid; other site
582744005911	ABC transporter signature motif; other site
582744005912	Walker B; other site
582744005913	D-loop; other site
582744005914	H-loop/switch region; other site
582744005915	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744005916	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744005917	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744005918	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744005919	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744005920	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
582744005921	hypothetical protein; Validated; Region: PRK09039
582744005922	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
582744005923	Outer membrane efflux protein; Region: OEP; pfam02321
582744005924	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
582744005925	putative hydrophobic ligand binding site [chemical binding]; other site
582744005926	protein interface [polypeptide binding]; other site
582744005927	gate; other site
582744005928	putative transcriptional regulator; Provisional; Region: PRK11640
582744005929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744005930	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
582744005931	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
582744005932	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744005933	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
582744005934	DNA binding residues [nucleotide binding]
582744005935	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
582744005936	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
582744005937	Era (E. coli Ras-like protein)-like.  This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880
582744005938	Switch II region; other site
582744005939	G3 box; other site
582744005940	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
582744005941	G4 box; other site
582744005942	G5 box; other site
582744005943	Protein of unknown function (DUF971); Region: DUF971; cl01414
582744005944	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
582744005945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744005946	S-adenosylmethionine binding site [chemical binding]; other site
582744005947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744005948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
582744005949	SCP-2 sterol transfer family; Region: SCP2; cl01225
582744005950	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
582744005951	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
582744005952	active site
582744005953	substrate binding site [chemical binding]; other site
582744005954	ATP binding site [chemical binding]; other site
582744005955	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744005956	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
582744005957	Sodium:solute symporter family; Region: SSF; cl00456
582744005958	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
582744005959	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
582744005960	DNA binding site [nucleotide binding]
582744005961	catalytic residue [active]
582744005962	H2TH interface [polypeptide binding]; other site
582744005963	putative catalytic residues [active]
582744005964	turnover-facilitating residue; other site
582744005965	intercalation triad [nucleotide binding]; other site
582744005966	8OG recognition residue [nucleotide binding]; other site
582744005967	putative reading head residues; other site
582744005968	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
582744005969	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
582744005970	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
582744005971	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
582744005972	ABC-2 type transporter; Region: ABC2_membrane; cl11417
582744005973	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
582744005974	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744005975	Walker A/P-loop; other site
582744005976	ATP binding site [chemical binding]; other site
582744005977	Q-loop/lid; other site
582744005978	ABC transporter signature motif; other site
582744005979	Walker B; other site
582744005980	D-loop; other site
582744005981	H-loop/switch region; other site
582744005982	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
582744005983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744005984	TPR motif; other site
582744005985	binding surface
582744005986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744005987	TPR motif; other site
582744005988	binding surface
582744005989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744005990	binding surface
582744005991	TPR motif; other site
582744005992	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
582744005993	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
582744005994	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
582744005995	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
582744005996	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923
582744005997	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
582744005998	Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495
582744005999	5S rRNA interface [nucleotide binding]; other site
582744006000	CTC domain interface; other site
582744006001	L16 interface [polypeptide binding]; other site
582744006002	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
582744006003	putative active site [active]
582744006004	catalytic residue [active]
582744006005	GTP-binding protein YchF; Reviewed; Region: PRK09601
582744006006	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
582744006007	G1 box; other site
582744006008	GTP/Mg2+ binding site [chemical binding]; other site
582744006009	Switch I region; other site
582744006010	G2 box; other site
582744006011	Switch II region; other site
582744006012	G3 box; other site
582744006013	G4 box; other site
582744006014	G5 box; other site
582744006015	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
582744006016	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582744006017	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
582744006018	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
582744006019	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582744006020	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
582744006021	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
582744006022	Chorismate mutase type II; Region: CM_2; cl00693
582744006023	KCNQ voltage-gated potassium channel; Region: KCNQ_channel; pfam03520
582744006024	YadA-like C-terminal region; Region: YadA; pfam03895
582744006025	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
582744006026	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650
582744006027	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
582744006028	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744006029	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
582744006030	Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479
582744006031	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
582744006032	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
582744006033	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
582744006034	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888
582744006035	phosphodiesterase; Provisional; Region: PRK12704
582744006036	type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759
582744006037	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744006038	Walker A motif; other site
582744006039	ATP binding site [chemical binding]; other site
582744006040	Walker B motif; other site
582744006041	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
582744006042	C-terminal domain; Region: primase_Cterm; TIGR01613
582744006043	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
582744006044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582744006045	Coenzyme A binding pocket [chemical binding]; other site
582744006046	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
582744006047	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
582744006048	Int/Topo IB signature motif; other site
582744006049	active site
582744006050	DNA binding site [nucleotide binding]
582744006051	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744006052	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
582744006053	Walker A/P-loop; other site
582744006054	ATP binding site [chemical binding]; other site
582744006055	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
582744006056	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744006057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
582744006058	dimerization interface [polypeptide binding]; other site
582744006059	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
582744006060	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
582744006061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
582744006062	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
582744006063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
582744006064	Staphylococcal nuclease homologues; Region: SNc; smart00318
582744006065	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
582744006066	Catalytic site; other site
582744006067	putative metal dependent hydrolase; Provisional; Region: PRK11598
582744006068	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
582744006069	Sulfatase; Region: Sulfatase; cl10460
582744006070	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
582744006071	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
582744006072	putative peptidoglycan binding site; other site
582744006073	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
582744006074	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
582744006075	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
582744006076	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
582744006077	DoxX; Region: DoxX; cl00976
582744006078	Pirin-related protein [General function prediction only]; Region: COG1741
582744006079	Cupin domain; Region: Cupin_2; cl09118
582744006080	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
582744006081	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
582744006082	LysR family transcriptional regulator; Provisional; Region: PRK14997
582744006083	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744006084	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582744006085	putative effector binding pocket; other site
582744006086	dimerization interface [polypeptide binding]; other site
582744006087	LexA repressor; Validated; Region: PRK00215
582744006088	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
582744006089	Catalytic site [active]
582744006090	FemAB family; Region: FemAB; cl11444
582744006091	Protein of unknown function, DUF482; Region: DUF482; pfam04339
582744006092	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051
582744006093	Ca2+ binding site [ion binding]; other site
582744006094	osmolarity response regulator; Provisional; Region: ompR; PRK09468
582744006095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744006096	active site
582744006097	phosphorylation site [posttranslational modification]
582744006098	intermolecular recognition site; other site
582744006099	dimerization interface [polypeptide binding]; other site
582744006100	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
582744006101	DNA binding site [nucleotide binding]
582744006102	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744006103	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744006104	dimer interface [polypeptide binding]; other site
582744006105	phosphorylation site [posttranslational modification]
582744006106	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744006107	ATP binding site [chemical binding]; other site
582744006108	Mg2+ binding site [ion binding]; other site
582744006109	G-X-G motif; other site
582744006110	siroheme synthase; Provisional; Region: cysG; PRK10637
582744006111	precorrin-2 dehydrogenase; Validated; Region: PRK06719
582744006112	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
582744006113	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
582744006114	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
582744006115	ChuX-like family; Region: DUF1008; cl01509
582744006116	ChuX-like family; Region: DUF1008; cl01509
582744006117	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
582744006118	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
582744006119	putative hemin binding site; other site
582744006120	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
582744006121	ABC-ATPase subunit  interface; other site
582744006122	dimer interface [polypeptide binding]; other site
582744006123	putative PBP binding regions; other site
582744006124	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
582744006125	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
582744006126	Walker A/P-loop; other site
582744006127	ATP binding site [chemical binding]; other site
582744006128	Q-loop/lid; other site
582744006129	ABC transporter signature motif; other site
582744006130	Walker B; other site
582744006131	D-loop; other site
582744006132	H-loop/switch region; other site
582744006133	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
582744006134	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
582744006135	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056
582744006136	TRAM domain; Region: TRAM; cl01282
582744006137	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
582744006138	PhoH-like protein; Region: PhoH; cl12134
582744006139	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
582744006140	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
582744006141	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582744006142	Transporter associated domain; Region: CorC_HlyC; pfam03471
582744006143	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
582744006144	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
582744006145	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
582744006146	putative active site [active]
582744006147	catalytic triad [active]
582744006148	putative dimer interface [polypeptide binding]; other site
582744006149	glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
582744006150	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
582744006151	dimer interface [polypeptide binding]; other site
582744006152	motif 1; other site
582744006153	active site
582744006154	motif 2; other site
582744006155	motif 3; other site
582744006156	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
582744006157	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
582744006158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
582744006159	active site
582744006160	motif I; other site
582744006161	motif II; other site
582744006162	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582744006163	putative acyl-acceptor binding pocket; other site
582744006164	Protein of unknown function DUF45; Region: DUF45; cl00636
582744006165	Predicted transcriptional regulator [Transcription]; Region: COG1959
582744006166	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744006167	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
582744006168	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
582744006169	heme-binding site [chemical binding]; other site
582744006170	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
582744006171	FAD binding pocket [chemical binding]; other site
582744006172	FAD binding motif [chemical binding]; other site
582744006173	phosphate binding motif [ion binding]; other site
582744006174	beta-alpha-beta structure motif; other site
582744006175	NAD binding pocket [chemical binding]; other site
582744006176	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
582744006177	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
582744006178	Ferritin-like domain; Region: Ferritin; pfam00210
582744006179	heme binding site [chemical binding]; other site
582744006180	ferroxidase pore; other site
582744006181	ferroxidase diiron center [ion binding]; other site
582744006182	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
582744006183	Ferritin-like domain; Region: Ferritin; pfam00210
582744006184	heme binding site [chemical binding]; other site
582744006185	ferroxidase pore; other site
582744006186	ferroxidase diiron center [ion binding]; other site
582744006187	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
582744006188	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
582744006189	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
582744006190	metal-binding site [ion binding]
582744006191	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
582744006192	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744006193	FixH; Region: FixH; cl01254
582744006194	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
582744006195	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
582744006196	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
582744006197	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
582744006198	Cytochrome c; Region: Cytochrom_C; cl11414
582744006199	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282
582744006200	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
582744006201	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661
582744006202	Low-spin heme binding site [chemical binding]; other site
582744006203	Putative water exit pathway; other site
582744006204	Binuclear center (active site) [active]
582744006205	Putative proton exit pathway; other site
582744006206	Surface antigen; Region: Surface_Ag_2; cl01155
582744006207	branched-chain amino acid aminotransferase; Provisional; Region: PRK12479
582744006208	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
582744006209	homodimer interface [polypeptide binding]; other site
582744006210	substrate-cofactor binding pocket; other site
582744006211	catalytic residue [active]
582744006212	Zinc-finger domain; Region: zf-CHCC; cl01821
582744006213	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
582744006214	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
582744006215	Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371
582744006216	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
582744006217	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744006218	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
582744006219	TOBE domain; Region: TOBE_2; cl01440
582744006220	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
582744006221	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
582744006222	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744006223	catalytic residue [active]
582744006224	serine acetyltransferase; Region: PLN02357
582744006225	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
582744006226	trimer interface [polypeptide binding]; other site
582744006227	active site
582744006228	substrate binding site [chemical binding]; other site
582744006229	CoA binding site [chemical binding]; other site
582744006230	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744006231	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744006232	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
582744006233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744006234	dimer interface [polypeptide binding]; other site
582744006235	conserved gate region; other site
582744006236	putative PBP binding loops; other site
582744006237	ABC-ATPase subunit interface; other site
582744006238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744006239	dimer interface [polypeptide binding]; other site
582744006240	conserved gate region; other site
582744006241	putative PBP binding loops; other site
582744006242	ABC-ATPase subunit interface; other site
582744006243	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
582744006244	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296
582744006245	Walker A/P-loop; other site
582744006246	ATP binding site [chemical binding]; other site
582744006247	Q-loop/lid; other site
582744006248	ABC transporter signature motif; other site
582744006249	Walker B; other site
582744006250	D-loop; other site
582744006251	H-loop/switch region; other site
582744006252	TOBE-like domain; Region: TOBE_3; pfam12857
582744006253	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
582744006254	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
582744006255	YeeE/YedE family (DUF395); Region: DUF395; cl01018
582744006256	YeeE/YedE family (DUF395); Region: DUF395; cl01018
582744006257	poly(A) polymerase; Region: pcnB; TIGR01942
582744006258	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
582744006259	active site
582744006260	NTP binding site [chemical binding]; other site
582744006261	metal binding triad [ion binding]; metal-binding site
582744006262	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
582744006263	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
582744006264	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
582744006265	catalytic center binding site [active]
582744006266	ATP binding site [chemical binding]; other site
582744006267	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
582744006268	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673
582744006269	Substrate-binding site [chemical binding]; other site
582744006270	Substrate specificity [chemical binding]; other site
582744006271	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
582744006272	oligomerization interface [polypeptide binding]; other site
582744006273	active site
582744006274	metal binding site [ion binding]; metal-binding site
582744006275	Pantoate-beta-alanine ligase; Region: PanC; cd00560
582744006276	pantoate--beta-alanine ligase; Region: panC; TIGR00018
582744006277	active site
582744006278	ATP-binding site [chemical binding]; other site
582744006279	pantoate-binding site; other site
582744006280	HXXH motif; other site
582744006281	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
582744006282	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744006283	substrate binding pocket [chemical binding]; other site
582744006284	Secretin and TonB N terminus short domain; Region: STN; pfam07660
582744006285	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
582744006286	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
582744006287	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
582744006288	FecR protein; Region: FecR; pfam04773
582744006289	RNA polymerase sigma factor; Reviewed; Region: PRK12527
582744006290	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744006291	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
582744006292	tetramerization interface [polypeptide binding]; other site
582744006293	active site
582744006294	Domain of unknown function DUF143; Region: DUF143; cl00519
582744006295	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
582744006296	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
582744006297	DNA photolyase; Region: DNA_photolyase; pfam00875
582744006298	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
582744006299	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
582744006300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744006301	putative substrate translocation pore; other site
582744006302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744006303	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354
582744006304	AMP binding site [chemical binding]; other site
582744006305	metal binding site [ion binding]; metal-binding site
582744006306	active site
582744006307	VacJ like lipoprotein; Region: VacJ; cl01073
582744006308	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
582744006309	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
582744006310	Protein of unknown function (DUF615); Region: DUF615; cl01147
582744006311	Site-specific recombinase; Region: SpecificRecomb; pfam10136
582744006312	Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389
582744006313	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
582744006314	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886
582744006315	MPT binding site; other site
582744006316	trimer interface [polypeptide binding]; other site
582744006317	thiamine monophosphate kinase; Provisional; Region: PRK05731
582744006318	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
582744006319	ATP binding site [chemical binding]; other site
582744006320	dimerization interface [polypeptide binding]; other site
582744006321	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
582744006322	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
582744006323	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
582744006324	tetramer interfaces [polypeptide binding]; other site
582744006325	binuclear metal-binding site [ion binding]; other site
582744006326	Competence-damaged protein; Region: CinA; cl00666
582744006327	recombinase A; Provisional; Region: recA; PRK09354
582744006328	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
582744006329	hexamer interface [polypeptide binding]; other site
582744006330	Walker A motif; other site
582744006331	ATP binding site [chemical binding]; other site
582744006332	Walker B motif; other site
582744006333	RecX family; Region: RecX; cl00936
582744006334	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
582744006335	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
582744006336	motif 1; other site
582744006337	active site
582744006338	motif 2; other site
582744006339	motif 3; other site
582744006340	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
582744006341	aspartate kinase; Reviewed; Region: PRK06635
582744006342	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
582744006343	putative nucleotide binding site [chemical binding]; other site
582744006344	putative catalytic residues [active]
582744006345	putative Mg ion binding site [ion binding]; other site
582744006346	putative aspartate binding site [chemical binding]; other site
582744006347	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
582744006348	putative allosteric regulatory site; other site
582744006349	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
582744006350	putative allosteric regulatory residue; other site
582744006351	hydroperoxidase II; Provisional; Region: katE; PRK11249
582744006352	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
582744006353	tetramer interface [polypeptide binding]; other site
582744006354	heme binding pocket [chemical binding]; other site
582744006355	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
582744006356	domain interactions; other site
582744006357	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
582744006358	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
582744006359	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744006360	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744006361	Malic enzyme, N-terminal domain; Region: malic; pfam00390
582744006362	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
582744006363	putative NAD(P) binding site [chemical binding]; other site
582744006364	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582744006365	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
582744006366	The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393
582744006367	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
582744006368	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
582744006369	Outer membrane efflux protein; Region: OEP; pfam02321
582744006370	Outer membrane efflux protein; Region: OEP; pfam02321
582744006371	CHASE3 domain; Region: CHASE3; cl05000
582744006372	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744006373	dimer interface [polypeptide binding]; other site
582744006374	phosphorylation site [posttranslational modification]
582744006375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744006376	ATP binding site [chemical binding]; other site
582744006377	Mg2+ binding site [ion binding]; other site
582744006378	G-X-G motif; other site
582744006379	Response regulator receiver domain; Region: Response_reg; pfam00072
582744006380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744006381	active site
582744006382	phosphorylation site [posttranslational modification]
582744006383	intermolecular recognition site; other site
582744006384	dimerization interface [polypeptide binding]; other site
582744006385	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582744006386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744006387	active site
582744006388	phosphorylation site [posttranslational modification]
582744006389	intermolecular recognition site; other site
582744006390	dimerization interface [polypeptide binding]; other site
582744006391	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744006392	PAS fold; Region: PAS_4; pfam08448
582744006393	bacterio-opsin activator; Provisional; Region: PRK13558
582744006394	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
582744006395	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744006396	metal binding site [ion binding]; metal-binding site
582744006397	active site
582744006398	I-site; other site
582744006399	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744006400	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
582744006401	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
582744006402	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
582744006403	HPP family; Region: HPP; pfam04982
582744006404	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010
582744006405	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
582744006406	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
582744006407	dinuclear metal binding motif [ion binding]; other site
582744006408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582744006409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744006410	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
582744006411	FMN binding site [chemical binding]; other site
582744006412	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
582744006413	dimer interface [polypeptide binding]; other site
582744006414	Domain of unknown function (DUF299); Region: DUF299; cl00780
582744006415	phosphoenolpyruvate synthase; Validated; Region: PRK06464
582744006416	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
582744006417	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
582744006418	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
582744006419	Protein of unknown function, DUF481; Region: DUF481; cl01213
582744006420	HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3
582744006421	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
582744006422	active site
582744006423	motif I; other site
582744006424	motif II; other site
582744006425	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
582744006426	active site
582744006427	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
582744006428	BON domain; Region: BON; cl02771
582744006429	YaeQ protein; Region: YaeQ; cl01913
582744006430	signal recognition particle protein; Provisional; Region: PRK10867
582744006431	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
582744006432	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
582744006433	P loop; other site
582744006434	GTP binding site [chemical binding]; other site
582744006435	Signal peptide binding domain; Region: SRP_SPB; pfam02978
582744006436	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
582744006437	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744006438	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
582744006439	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
582744006440	2-isopropylmalate synthase; Validated; Region: PRK00915
582744006441	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
582744006442	active site
582744006443	catalytic residues [active]
582744006444	metal binding site [ion binding]; metal-binding site
582744006445	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
582744006446	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
582744006447	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
582744006448	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
582744006449	Preprotein translocase subunit; Region: YajC; cl00806
582744006450	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
582744006451	Protein export membrane protein; Region: SecD_SecF; cl14618
582744006452	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
582744006453	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
582744006454	Protein export membrane protein; Region: SecD_SecF; cl14618
582744006455	Domain of unknown function DUF21; Region: DUF21; pfam01595
582744006456	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
582744006457	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582744006458	Transporter associated domain; Region: CorC_HlyC; pfam03471
582744006459	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
582744006460	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
582744006461	Clp amino terminal domain; Region: Clp_N; pfam02861
582744006462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744006463	Walker A motif; other site
582744006464	ATP binding site [chemical binding]; other site
582744006465	Walker B motif; other site
582744006466	arginine finger; other site
582744006467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744006468	Walker A motif; other site
582744006469	ATP binding site [chemical binding]; other site
582744006470	Walker B motif; other site
582744006471	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
582744006472	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
582744006473	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
582744006474	GST_C family, unknown subfamily 5; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_5; cd03196
582744006475	putative N-terminal domain interface [polypeptide binding]; other site
582744006476	putative dimer interface [polypeptide binding]; other site
582744006477	putative substrate binding pocket (H-site) [chemical binding]; other site
582744006478	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
582744006479	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738
582744006480	quinone interaction residues [chemical binding]; other site
582744006481	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
582744006482	active site
582744006483	catalytic residues [active]
582744006484	FMN binding site [chemical binding]; other site
582744006485	substrate binding site [chemical binding]; other site
582744006486	Nitrogen regulatory protein P-II; Region: P-II; cl00412
582744006487	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582744006488	Nitrogen regulatory protein P-II; Region: P-II; cl00412
582744006489	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
582744006490	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582744006491	Outer membrane efflux protein; Region: OEP; pfam02321
582744006492	Outer membrane efflux protein; Region: OEP; pfam02321
582744006493	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
582744006494	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
582744006495	active site
582744006496	HIGH motif; other site
582744006497	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
582744006498	KMSKS motif; other site
582744006499	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
582744006500	tRNA binding surface [nucleotide binding]; other site
582744006501	anticodon binding site; other site
582744006502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744006503	binding surface
582744006504	TPR motif; other site
582744006505	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
582744006506	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
582744006507	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
582744006508	substrate binding site [chemical binding]; other site
582744006509	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
582744006510	substrate binding site [chemical binding]; other site
582744006511	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
582744006512	putative active site [active]
582744006513	putative metal binding site [ion binding]; other site
582744006514	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
582744006515	phosphopeptide binding site; other site
582744006516	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
582744006517	putative RNA binding site [nucleotide binding]; other site
582744006518	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
582744006519	homopentamer interface [polypeptide binding]; other site
582744006520	active site
582744006521	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
582744006522	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
582744006523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744006524	active site
582744006525	phosphorylation site [posttranslational modification]
582744006526	intermolecular recognition site; other site
582744006527	dimerization interface [polypeptide binding]; other site
582744006528	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
582744006529	DNA binding site [nucleotide binding]
582744006530	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
582744006531	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
582744006532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744006533	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744006534	dimer interface [polypeptide binding]; other site
582744006535	phosphorylation site [posttranslational modification]
582744006536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744006537	ATP binding site [chemical binding]; other site
582744006538	Mg2+ binding site [ion binding]; other site
582744006539	G-X-G motif; other site
582744006540	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
582744006541	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
582744006542	FAD binding domain; Region: FAD_binding_4; pfam01565
582744006543	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
582744006544	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
582744006545	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
582744006546	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
582744006547	catalytic residues [active]
582744006548	Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863
582744006549	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
582744006550	putative hydrophobic ligand binding site [chemical binding]; other site
582744006551	protein interface [polypeptide binding]; other site
582744006552	gate; other site
582744006553	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582744006554	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744006555	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
582744006556	substrate binding site [chemical binding]; other site
582744006557	ATP binding site [chemical binding]; other site
582744006558	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
582744006559	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
582744006560	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
582744006561	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582744006562	putative acyl-acceptor binding pocket; other site
582744006563	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
582744006564	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
582744006565	active site
582744006566	metal binding site [ion binding]; metal-binding site
582744006567	Cytochrome c; Region: Cytochrom_C; cl11414
582744006568	Cytochrome c; Region: Cytochrom_C; cl11414
582744006569	Sulfatase; Region: Sulfatase; cl10460
582744006570	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
582744006571	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
582744006572	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
582744006573	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
582744006574	N-acetyl-D-glucosamine binding site [chemical binding]; other site
582744006575	catalytic residue [active]
582744006576	prolyl-tRNA synthetase; Provisional; Region: PRK09194
582744006577	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
582744006578	dimer interface [polypeptide binding]; other site
582744006579	motif 1; other site
582744006580	active site
582744006581	motif 2; other site
582744006582	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
582744006583	putative deacylase active site [active]
582744006584	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
582744006585	active site
582744006586	motif 3; other site
582744006587	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
582744006588	anticodon binding site; other site
582744006589	Domain of unknown function (DUF477); Region: DUF477; cl01535
582744006590	Domain of unknown function (DUF477); Region: DUF477; cl01535
582744006591	LemA family; Region: LemA; cl00742
582744006592	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
582744006593	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
582744006594	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582744006595	Coenzyme A binding pocket [chemical binding]; other site
582744006596	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
582744006597	RF-1 domain; Region: RF-1; cl02875
582744006598	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
582744006599	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
582744006600	EamA-like transporter family; Region: EamA; cl01037
582744006601	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
582744006602	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
582744006603	ring oligomerisation interface [polypeptide binding]; other site
582744006604	ATP/Mg binding site [chemical binding]; other site
582744006605	stacking interactions; other site
582744006606	hinge regions; other site
582744006607	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
582744006608	oligomerisation interface [polypeptide binding]; other site
582744006609	mobile loop; other site
582744006610	roof hairpin; other site
582744006611	Domain of unknown function DUF; Region: DUF202; cl09954
582744006612	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
582744006613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744006614	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
582744006615	transcriptional regulator; Provisional; Region: PRK10632
582744006616	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744006617	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582744006618	putative effector binding pocket; other site
582744006619	dimerization interface [polypeptide binding]; other site
582744006620	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
582744006621	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744006622	DEAD_2; Region: DEAD_2; cl14887
582744006623	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250
582744006624	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
582744006625	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
582744006626	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings...; Region: proteasome_beta_bacterial; cd03765
582744006627	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
582744006628	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
582744006629	active site
582744006630	catalytic tetrad [active]
582744006631	Protein of unknown function (DUF3034); Region: DUF3034; pfam11231
582744006632	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454
582744006633	apolar tunnel; other site
582744006634	heme binding site [chemical binding]; other site
582744006635	dimerization interface [polypeptide binding]; other site
582744006636	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
582744006637	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
582744006638	dimerization interface [polypeptide binding]; other site
582744006639	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744006640	metal binding site [ion binding]; metal-binding site
582744006641	active site
582744006642	I-site; other site
582744006643	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744006644	Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418
582744006645	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
582744006646	active site
582744006647	substrate binding pocket [chemical binding]; other site
582744006648	dimer interface [polypeptide binding]; other site
582744006649	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
582744006650	Predicted methyltransferases [General function prediction only]; Region: COG0313
582744006651	LppC putative lipoprotein; Region: LppC; pfam04348
582744006652	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
582744006653	putative ligand binding site [chemical binding]; other site
582744006654	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
582744006655	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
582744006656	dimer interface [polypeptide binding]; other site
582744006657	active site
582744006658	BON domain; Region: BON; cl02771
582744006659	BON domain; Region: BON; cl02771
582744006660	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
582744006661	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
582744006662	catalytic residues [active]
582744006663	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
582744006664	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744006665	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
582744006666	catalytic residues [active]
582744006667	transcription termination factor Rho; Provisional; Region: rho; PRK09376
582744006668	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
582744006669	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
582744006670	RNA binding site [nucleotide binding]; other site
582744006671	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
582744006672	multimer interface [polypeptide binding]; other site
582744006673	Walker A motif; other site
582744006674	ATP binding site [chemical binding]; other site
582744006675	Walker B motif; other site
582744006676	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
582744006677	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
582744006678	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744006679	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
582744006680	Walker A/P-loop; other site
582744006681	ATP binding site [chemical binding]; other site
582744006682	Q-loop/lid; other site
582744006683	ABC transporter signature motif; other site
582744006684	Walker B; other site
582744006685	D-loop; other site
582744006686	H-loop/switch region; other site
582744006687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744006688	dimer interface [polypeptide binding]; other site
582744006689	conserved gate region; other site
582744006690	putative PBP binding loops; other site
582744006691	ABC-ATPase subunit interface; other site
582744006692	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744006693	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
582744006694	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744006695	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
582744006696	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744006697	FeS/SAM binding site; other site
582744006698	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
582744006699	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
582744006700	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
582744006701	GTP binding site [chemical binding]; other site
582744006702	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116
582744006703	Walker A motif; other site
582744006704	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
582744006705	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
582744006706	dimer interface [polypeptide binding]; other site
582744006707	putative functional site; other site
582744006708	putative MPT binding site; other site
582744006709	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
582744006710	dimer interface [polypeptide binding]; other site
582744006711	putative metal binding site [ion binding]; other site
582744006712	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
582744006713	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744006714	N-terminal plug; other site
582744006715	ligand-binding site [chemical binding]; other site
582744006716	Predicted secreted protein [Function unknown]; Region: COG5501; cl02313
582744006717	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
582744006718	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
582744006719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
582744006720	Gram-negative bacterial tonB protein; Region: TonB; cl10048
582744006721	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744006722	adaptive-response sensory kinase; Validated; Region: PRK09303
582744006723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
582744006724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744006725	ATP binding site [chemical binding]; other site
582744006726	G-X-G motif; other site
582744006727	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
582744006728	catalytic triad [active]
582744006729	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
582744006730	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
582744006731	putative active site [active]
582744006732	PhoH-like protein; Region: PhoH; cl12134
582744006733	lysophospholipid transporter LplT; Provisional; Region: PRK11195
582744006734	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
582744006735	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744006736	Cytochrome c; Region: Cytochrom_C; cl11414
582744006737	Cytochrome c; Region: Cytochrom_C; cl11414
582744006738	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
582744006739	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
582744006740	substrate binding pocket [chemical binding]; other site
582744006741	membrane-bound complex binding site; other site
582744006742	hinge residues; other site
582744006743	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582744006744	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
582744006745	Trp docking motif; other site
582744006746	'Velcro' closure; other site
582744006747	active site
582744006748	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
582744006749	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744006750	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
582744006751	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582744006752	ligand binding site [chemical binding]; other site
582744006753	flexible hinge region; other site
582744006754	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
582744006755	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
582744006756	active site residue [active]
582744006757	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
582744006758	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
582744006759	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
582744006760	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
582744006761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582744006762	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744006763	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582744006764	putative effector binding pocket; other site
582744006765	dimerization interface [polypeptide binding]; other site
582744006766	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582744006767	classical (c) SDRs; Region: SDR_c; cd05233
582744006768	NAD(P) binding site [chemical binding]; other site
582744006769	active site
582744006770	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582744006771	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744006772	NAD(P) binding site [chemical binding]; other site
582744006773	active site
582744006774	chromosome segregation protein; Provisional; Region: PRK03918
582744006775	Fic family protein [Function unknown]; Region: COG3177
582744006776	Fic/DOC family; Region: Fic; cl00960
582744006777	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
582744006778	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
582744006779	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
582744006780	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
582744006781	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
582744006782	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
582744006783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744006784	active site
582744006785	phosphorylation site [posttranslational modification]
582744006786	intermolecular recognition site; other site
582744006787	dimerization interface [polypeptide binding]; other site
582744006788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
582744006789	DNA binding site [nucleotide binding]
582744006790	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744006791	dimer interface [polypeptide binding]; other site
582744006792	phosphorylation site [posttranslational modification]
582744006793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744006794	ATP binding site [chemical binding]; other site
582744006795	Mg2+ binding site [ion binding]; other site
582744006796	G-X-G motif; other site
582744006797	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
582744006798	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
582744006799	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
582744006800	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
582744006801	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
582744006802	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
582744006803	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
582744006804	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
582744006805	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744006806	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
582744006807	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
582744006808	DNA binding residues [nucleotide binding]
582744006809	DNA primase; Validated; Region: dnaG; PRK05667
582744006810	CHC2 zinc finger; Region: zf-CHC2; cl02597
582744006811	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
582744006812	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
582744006813	active site
582744006814	metal binding site [ion binding]; metal-binding site
582744006815	interdomain interaction site; other site
582744006816	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
582744006817	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
582744006818	GatB domain; Region: GatB_Yqey; cl11497
582744006819	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
582744006820	UGMP family protein; Validated; Region: PRK09604
582744006821	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
582744006822	Domain of unknown function (DUF205); Region: DUF205; cl00410
582744006823	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534
582744006824	homooctamer interface [polypeptide binding]; other site
582744006825	active site
582744006826	TIGR03790 family protein; Region: TIGR03790
582744006827	hypothetical protein; Provisional; Region: PRK04233
582744006828	SEC-C motif; Region: SEC-C; cl12132
582744006829	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
582744006830	N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798
582744006831	Int/Topo IB signature motif; other site
582744006832	active site
582744006833	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
582744006834	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
582744006835	DNA binding site [nucleotide binding]
582744006836	active site
582744006837	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
582744006838	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
582744006839	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
582744006840	RimM N-terminal domain; Region: RimM; pfam01782
582744006841	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
582744006842	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
582744006843	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
582744006844	Ligand Binding Site [chemical binding]; other site
582744006845	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
582744006846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744006847	FeS/SAM binding site; other site
582744006848	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
582744006849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744006850	TPR motif; other site
582744006851	binding surface
582744006852	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
582744006853	ligand binding site [chemical binding]; other site
582744006854	TolB amino-terminal domain; Region: TolB_N; pfam04052
582744006855	translocation protein TolB; Provisional; Region: tolB; PRK02889
582744006856	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582744006857	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582744006858	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
582744006859	TolA protein; Region: tolA_full; TIGR02794
582744006860	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
582744006861	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
582744006862	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
582744006863	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
582744006864	active site
582744006865	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
582744006866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744006867	Walker A motif; other site
582744006868	ATP binding site [chemical binding]; other site
582744006869	Walker B motif; other site
582744006870	arginine finger; other site
582744006871	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
582744006872	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
582744006873	RuvA N terminal domain; Region: RuvA_N; pfam01330
582744006874	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
582744006875	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
582744006876	active site
582744006877	putative DNA-binding cleft [nucleotide binding]; other site
582744006878	dimer interface [polypeptide binding]; other site
582744006879	Domain of unknown function DUF28; Region: DUF28; cl00361
582744006880	EamA-like transporter family; Region: EamA; cl01037
582744006881	EamA-like transporter family; Region: EamA; cl01037
582744006882	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
582744006883	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744006884	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623
582744006885	FOG: CBS domain [General function prediction only]; Region: COG0517
582744006886	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
582744006887	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
582744006888	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744006889	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
582744006890	Uncharacterised protein family UPF0047; Region: UPF0047; cl00439
582744006891	Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774
582744006892	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
582744006893	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
582744006894	catalytic triad [active]
582744006895	Maltose operon periplasmic protein precursor (MalM); Region: MalM; cl11647
582744006896	Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969
582744006897	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
582744006898	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
582744006899	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
582744006900	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
582744006901	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
582744006902	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
582744006903	active site
582744006904	FMN binding site [chemical binding]; other site
582744006905	substrate binding site [chemical binding]; other site
582744006906	3Fe-4S cluster binding site [ion binding]; other site
582744006907	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
582744006908	domain_subunit interface; other site
582744006909	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
582744006910	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
582744006911	putative active site [active]
582744006912	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
582744006913	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
582744006914	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582744006915	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
582744006916	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
582744006917	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744006918	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
582744006919	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
582744006920	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582744006921	Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767
582744006922	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
582744006923	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
582744006924	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
582744006925	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582744006926	non-specific DNA binding site [nucleotide binding]; other site
582744006927	salt bridge; other site
582744006928	sequence-specific DNA binding site [nucleotide binding]; other site
582744006929	Cupin domain; Region: Cupin_2; cl09118
582744006930	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
582744006931	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582744006932	Coenzyme A binding pocket [chemical binding]; other site
582744006933	Domain of unknown function DUF140; Region: DUF140; cl00510
582744006934	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
582744006935	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744006936	Walker A/P-loop; other site
582744006937	ATP binding site [chemical binding]; other site
582744006938	Q-loop/lid; other site
582744006939	ABC transporter signature motif; other site
582744006940	Walker B; other site
582744006941	D-loop; other site
582744006942	H-loop/switch region; other site
582744006943	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
582744006944	mce related protein; Region: MCE; cl03606
582744006945	Protein of unknown function (DUF330); Region: DUF330; cl01135
582744006946	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
582744006947	phospholipase D alpha; Region: PLN02270
582744006948	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
582744006949	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
582744006950	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
582744006951	putative active site [active]
582744006952	putative active site [active]
582744006953	catalytic site [active]
582744006954	catalytic site [active]
582744006955	CCC1-related family of proteins; Region: CCC1_like; cl00278
582744006956	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
582744006957	PAS fold; Region: PAS; pfam00989
582744006958	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744006959	putative active site [active]
582744006960	heme pocket [chemical binding]; other site
582744006961	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744006962	metal binding site [ion binding]; metal-binding site
582744006963	active site
582744006964	I-site; other site
582744006965	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744006966	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
582744006967	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
582744006968	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
582744006969	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
582744006970	putative active site [active]
582744006971	putative metal binding site [ion binding]; other site
582744006972	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
582744006973	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
582744006974	active site
582744006975	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
582744006976	GAF domain; Region: GAF; cl00853
582744006977	PAS domain S-box; Region: sensory_box; TIGR00229
582744006978	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744006979	putative active site [active]
582744006980	heme pocket [chemical binding]; other site
582744006981	PAS domain S-box; Region: sensory_box; TIGR00229
582744006982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744006983	putative active site [active]
582744006984	heme pocket [chemical binding]; other site
582744006985	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744006986	metal binding site [ion binding]; metal-binding site
582744006987	active site
582744006988	I-site; other site
582744006989	PEP-CTERM motif; Region: VPEP; pfam07589
582744006990	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
582744006991	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744006992	N-terminal plug; other site
582744006993	ligand-binding site [chemical binding]; other site
582744006994	RDD family; Region: RDD; cl00746
582744006995	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
582744006996	putative active site [active]
582744006997	catalytic site [active]
582744006998	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
582744006999	putative active site [active]
582744007000	catalytic site [active]
582744007001	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
582744007002	putative catalytic site [active]
582744007003	putative metal binding site [ion binding]; other site
582744007004	putative phosphate binding site [ion binding]; other site
582744007005	Quinolinate synthetase A protein; Region: NadA; cl00420
582744007006	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
582744007007	nudix motif; other site
582744007008	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
582744007009	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
582744007010	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
582744007011	dimer interface [polypeptide binding]; other site
582744007012	anticodon binding site; other site
582744007013	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
582744007014	homodimer interface [polypeptide binding]; other site
582744007015	motif 1; other site
582744007016	active site
582744007017	motif 2; other site
582744007018	GAD domain; Region: GAD; pfam02938
582744007019	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
582744007020	motif 3; other site
582744007021	Protein of unknown function (DUF502); Region: DUF502; cl01107
582744007022	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
582744007023	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
582744007024	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
582744007025	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
582744007026	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
582744007027	Ligand binding site [chemical binding]; other site
582744007028	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859
582744007029	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
582744007030	Cysteine-rich domain; Region: CCG; pfam02754
582744007031	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
582744007032	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
582744007033	FMN binding site [chemical binding]; other site
582744007034	active site
582744007035	homodimer interface [polypeptide binding]; other site
582744007036	putative catalytic residue [active]
582744007037	4Fe-4S cluster binding site [ion binding]; other site
582744007038	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744007039	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
582744007040	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
582744007041	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
582744007042	transcriptional regulator NarL; Provisional; Region: PRK10651
582744007043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744007044	active site
582744007045	phosphorylation site [posttranslational modification]
582744007046	intermolecular recognition site; other site
582744007047	dimerization interface [polypeptide binding]; other site
582744007048	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
582744007049	DNA binding residues [nucleotide binding]
582744007050	dimerization interface [polypeptide binding]; other site
582744007051	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
582744007052	Histidine kinase; Region: HisKA_3; pfam07730
582744007053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
582744007054	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582744007055	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007056	putative active site [active]
582744007057	heme pocket [chemical binding]; other site
582744007058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007059	putative active site [active]
582744007060	heme pocket [chemical binding]; other site
582744007061	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007062	PAS fold; Region: PAS_3; pfam08447
582744007063	putative active site [active]
582744007064	heme pocket [chemical binding]; other site
582744007065	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
582744007066	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
582744007067	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
582744007068	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185
582744007069	FMN-binding pocket [chemical binding]; other site
582744007070	flavin binding motif; other site
582744007071	phosphate binding motif [ion binding]; other site
582744007072	beta-alpha-beta structure motif; other site
582744007073	NAD binding pocket [chemical binding]; other site
582744007074	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
582744007075	catalytic loop [active]
582744007076	iron binding site [ion binding]; other site
582744007077	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
582744007078	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
582744007079	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
582744007080	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
582744007081	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744007082	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007083	PAS fold; Region: PAS_3; pfam08447
582744007084	putative active site [active]
582744007085	heme pocket [chemical binding]; other site
582744007086	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007087	metal binding site [ion binding]; metal-binding site
582744007088	active site
582744007089	I-site; other site
582744007090	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744007091	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
582744007092	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
582744007093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744007094	dimer interface [polypeptide binding]; other site
582744007095	phosphorylation site [posttranslational modification]
582744007096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744007097	ATP binding site [chemical binding]; other site
582744007098	Mg2+ binding site [ion binding]; other site
582744007099	G-X-G motif; other site
582744007100	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
582744007101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744007102	active site
582744007103	phosphorylation site [posttranslational modification]
582744007104	intermolecular recognition site; other site
582744007105	dimerization interface [polypeptide binding]; other site
582744007106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
582744007107	DNA binding site [nucleotide binding]
582744007108	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
582744007109	putative hydrophobic ligand binding site [chemical binding]; other site
582744007110	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
582744007111	transcriptional regulator; Provisional; Region: PRK10632
582744007112	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007113	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
582744007114	putative effector binding pocket; other site
582744007115	putative dimerization interface [polypeptide binding]; other site
582744007116	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582744007117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744007118	NAD(P) binding site [chemical binding]; other site
582744007119	active site
582744007120	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744007121	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
582744007122	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582744007123	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
582744007124	NodT family; Region: outer_NodT; TIGR01845
582744007125	Outer membrane efflux protein; Region: OEP; pfam02321
582744007126	Outer membrane efflux protein; Region: OEP; pfam02321
582744007127	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007128	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582744007129	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007130	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
582744007131	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
582744007132	dimer interface [polypeptide binding]; other site
582744007133	ssDNA binding site [nucleotide binding]; other site
582744007134	tetramer (dimer of dimers) interface [polypeptide binding]; other site
582744007135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744007136	Major Facilitator Superfamily; Region: MFS_1; pfam07690
582744007137	putative substrate translocation pore; other site
582744007138	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
582744007139	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
582744007140	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
582744007141	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
582744007142	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744007143	Transglycosylase; Region: Transgly; cl07896
582744007144	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
582744007145	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
582744007146	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
582744007147	shikimate binding site; other site
582744007148	NAD(P) binding site [chemical binding]; other site
582744007149	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
582744007150	active site residue [active]
582744007151	glutamine synthetase; Provisional; Region: glnA; PRK09469
582744007152	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
582744007153	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
582744007154	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
582744007155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744007156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744007157	dimer interface [polypeptide binding]; other site
582744007158	phosphorylation site [posttranslational modification]
582744007159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744007160	ATP binding site [chemical binding]; other site
582744007161	Mg2+ binding site [ion binding]; other site
582744007162	G-X-G motif; other site
582744007163	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
582744007164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744007165	active site
582744007166	phosphorylation site [posttranslational modification]
582744007167	intermolecular recognition site; other site
582744007168	dimerization interface [polypeptide binding]; other site
582744007169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744007170	Walker A motif; other site
582744007171	ATP binding site [chemical binding]; other site
582744007172	Walker B motif; other site
582744007173	arginine finger; other site
582744007174	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744007175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744007176	binding surface
582744007177	TPR motif; other site
582744007178	Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711
582744007179	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
582744007180	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
582744007181	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
582744007182	active site
582744007183	dimer interface [polypeptide binding]; other site
582744007184	metal binding site [ion binding]; metal-binding site
582744007185	shikimate kinase; Reviewed; Region: aroK; PRK00131
582744007186	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
582744007187	ADP binding site [chemical binding]; other site
582744007188	magnesium binding site [ion binding]; other site
582744007189	putative shikimate binding site; other site
582744007190	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
582744007191	Secretin and TonB N terminus short domain; Region: STN; pfam07660
582744007192	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
582744007193	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
582744007194	Pilus assembly protein, PilP; Region: PilP; cl01235
582744007195	Pilus assembly protein, PilO; Region: PilO; cl01234
582744007196	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
582744007197	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
582744007198	Competence protein A; Region: Competence_A; pfam11104
582744007199	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
582744007200	Transglycosylase; Region: Transgly; cl07896
582744007201	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
582744007202	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
582744007203	dimer interface [polypeptide binding]; other site
582744007204	allosteric magnesium binding site [ion binding]; other site
582744007205	active site
582744007206	aspartate-rich active site metal binding site; other site
582744007207	Schiff base residues; other site
582744007208	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
582744007209	active site
582744007210	ribulose/triose binding site [chemical binding]; other site
582744007211	phosphate binding site [ion binding]; other site
582744007212	substrate (anthranilate) binding pocket [chemical binding]; other site
582744007213	product (indole) binding pocket [chemical binding]; other site
582744007214	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
582744007215	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
582744007216	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
582744007217	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
582744007218	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
582744007219	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
582744007220	glutamine binding [chemical binding]; other site
582744007221	catalytic triad [active]
582744007222	anthranilate synthase component I; Provisional; Region: PRK13565
582744007223	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
582744007224	chorismate binding enzyme; Region: Chorismate_bind; cl10555
582744007225	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
582744007226	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
582744007227	motif II; other site
582744007228	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
582744007229	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
582744007230	substrate binding site [chemical binding]; other site
582744007231	hexamer interface [polypeptide binding]; other site
582744007232	metal binding site [ion binding]; metal-binding site
582744007233	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
582744007234	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
582744007235	tRNA; other site
582744007236	putative tRNA binding site [nucleotide binding]; other site
582744007237	putative NADP binding site [chemical binding]; other site
582744007238	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
582744007239	peptide chain release factor 1; Validated; Region: prfA; PRK00591
582744007240	RF-1 domain; Region: RF-1; cl02875
582744007241	RF-1 domain; Region: RF-1; cl02875
582744007242	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
582744007243	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
582744007244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744007245	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
582744007246	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
582744007247	trimer interface [polypeptide binding]; other site
582744007248	putative metal binding site [ion binding]; other site
582744007249	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744007250	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
582744007251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744007252	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
582744007253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744007254	muropeptide transporter; Reviewed; Region: ampG; PRK11902
582744007255	putative substrate translocation pore; other site
582744007256	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
582744007257	putative active site [active]
582744007258	putative DNA binding site [nucleotide binding]; other site
582744007259	putative phosphate binding site [ion binding]; other site
582744007260	putative catalytic site [active]
582744007261	metal binding site A [ion binding]; metal-binding site
582744007262	putative AP binding site [nucleotide binding]; other site
582744007263	putative metal binding site B [ion binding]; other site
582744007264	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
582744007265	Uracil DNA glycosylase superfamily; Region: UDG; cl00483
582744007266	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
582744007267	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
582744007268	GatB domain; Region: GatB_Yqey; cl11497
582744007269	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
582744007270	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
582744007271	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
582744007272	rod shape-determining protein MreB; Provisional; Region: PRK13927
582744007273	Cell division protein FtsA; Region: FtsA; cl11496
582744007274	rod shape-determining protein MreC; Provisional; Region: PRK13922
582744007275	rod shape-determining protein MreC; Region: MreC; pfam04085
582744007276	rod shape-determining protein MreD; Region: MreD; cl01087
582744007277	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
582744007278	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
582744007279	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
582744007280	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
582744007281	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
582744007282	Sporulation related domain; Region: SPOR; cl10051
582744007283	Beta-lactamase; Region: Beta-lactamase; cl01009
582744007284	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
582744007285	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
582744007286	branched-chain amino acid aminotransferase; Provisional; Region: PRK12479
582744007287	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558
582744007288	homodimer interface [polypeptide binding]; other site
582744007289	substrate-cofactor binding pocket; other site
582744007290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744007291	catalytic residue [active]
582744007292	Protein of unknown function (DUF493); Region: DUF493; cl01102
582744007293	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
582744007294	lipoyl synthase; Provisional; Region: PRK05481
582744007295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
582744007296	FeS/SAM binding site; other site
582744007297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
582744007298	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582744007299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582744007300	DNA-binding site [nucleotide binding]; DNA binding site
582744007301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744007302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744007303	homodimer interface [polypeptide binding]; other site
582744007304	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
582744007305	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
582744007306	Trp docking motif; other site
582744007307	'Velcro' closure; other site
582744007308	active site
582744007309	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
582744007310	phosphoribosylamine--glycine ligase; Provisional; Region: PRK13790
582744007311	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744007312	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
582744007313	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744007314	S-adenosylmethionine binding site [chemical binding]; other site
582744007315	Copper resistance protein CopC; Region: CopC; cl01012
582744007316	Cytochrome c [Energy production and conversion]; Region: COG3258
582744007317	Cytochrome c; Region: Cytochrom_C; cl11414
582744007318	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
582744007319	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275
582744007320	Low-spin heme binding site [chemical binding]; other site
582744007321	D-pathway; other site
582744007322	Putative water exit pathway; other site
582744007323	Binuclear center (active site) [active]
582744007324	K-pathway; other site
582744007325	Putative proton exit pathway; other site
582744007326	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
582744007327	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
582744007328	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
582744007329	trehalose synthase; Region: treS_nterm; TIGR02456
582744007330	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
582744007331	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
582744007332	Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853
582744007333	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
582744007334	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
582744007335	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
582744007336	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
582744007337	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
582744007338	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
582744007339	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
582744007340	putative DNA binding site [nucleotide binding]; other site
582744007341	putative homodimer interface [polypeptide binding]; other site
582744007342	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
582744007343	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
582744007344	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
582744007345	active site
582744007346	DNA binding site [nucleotide binding]
582744007347	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
582744007348	DNA binding site [nucleotide binding]
582744007349	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: PaeLigD_Pol_like; cd04862
582744007350	nucleotide binding site [chemical binding]; other site
582744007351	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206
582744007352	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
582744007353	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
582744007354	nucleotide binding site/active site [active]
582744007355	HIT family signature motif; other site
582744007356	catalytic residue [active]
582744007357	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
582744007358	dimer interface [polypeptide binding]; other site
582744007359	[2Fe-2S] cluster binding site [ion binding]; other site
582744007360	Gram-negative bacterial tonB protein; Region: TonB; cl10048
582744007361	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
582744007362	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
582744007363	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
582744007364	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
582744007365	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
582744007366	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744007367	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
582744007368	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
582744007369	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
582744007370	substrate binding pocket [chemical binding]; other site
582744007371	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
582744007372	B12 binding site [chemical binding]; other site
582744007373	cobalt ligand [ion binding]; other site
582744007374	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
582744007375	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
582744007376	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
582744007377	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744007378	Membrane fusogenic activity; Region: BMFP; cl01115
582744007379	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
582744007380	Nitrogen regulatory protein P-II; Region: P-II; cl00412
582744007381	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
582744007382	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
582744007383	Glutamate-cysteine ligase; Region: GshA; pfam08886
582744007384	glutathione synthetase; Provisional; Region: PRK05246
582744007385	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
582744007386	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
582744007387	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
582744007388	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
582744007389	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
582744007390	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
582744007391	Type II transport protein GspH; Region: GspH; pfam12019
582744007392	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
582744007393	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
582744007394	diaminopimelate decarboxylase; Region: lysA; TIGR01048
582744007395	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
582744007396	active site
582744007397	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
582744007398	substrate binding site [chemical binding]; other site
582744007399	catalytic residues [active]
582744007400	dimer interface [polypeptide binding]; other site
582744007401	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
582744007402	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
582744007403	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
582744007404	putative active site [active]
582744007405	putative substrate binding site [chemical binding]; other site
582744007406	putative cosubstrate binding site; other site
582744007407	catalytic site [active]
582744007408	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
582744007409	CobD/Cbib protein; Region: CobD_Cbib; cl00561
582744007410	LytB protein; Region: LYTB; cl00507
582744007411	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
582744007412	DoxX; Region: DoxX; cl00976
582744007413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
582744007414	Coenzyme A binding pocket [chemical binding]; other site
582744007415	Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774
582744007416	putative transporter; Provisional; Region: PRK11660
582744007417	Sulfate transporter family; Region: Sulfate_transp; cl00967
582744007418	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
582744007419	adenine DNA glycosylase; Provisional; Region: PRK10880
582744007420	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
582744007421	minor groove reading motif; other site
582744007422	helix-hairpin-helix signature motif; other site
582744007423	substrate binding pocket [chemical binding]; other site
582744007424	active site
582744007425	FES domain; Region: FES; smart00525
582744007426	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
582744007427	DNA binding and oxoG recognition site [nucleotide binding]
582744007428	AsmA family; Region: AsmA; pfam05170
582744007429	putative assembly protein; Provisional; Region: PRK10833
582744007430	AsmA family; Region: AsmA; pfam05170
582744007431	Predicted membrane protein [Function unknown]; Region: COG3164
582744007432	Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617
582744007433	Bacitracin resistance protein BacA; Region: BacA; cl00858
582744007434	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
582744007435	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
582744007436	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
582744007437	RNA binding surface [nucleotide binding]; other site
582744007438	PSSA_1: Pseudouridine synthase, a subgroup of the RsuA family. This group is comprised of bacterial proteins assigned to the RsuA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSSA_1; cd02555
582744007439	active site
582744007440	ThiC family; Region: ThiC; cl08031
582744007441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744007442	TPR motif; other site
582744007443	binding surface
582744007444	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
582744007445	classical (c) SDRs; Region: SDR_c; cd05233
582744007446	NAD(P) binding site [chemical binding]; other site
582744007447	active site
582744007448	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
582744007449	heme binding pocket [chemical binding]; other site
582744007450	heme ligand [chemical binding]; other site
582744007451	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
582744007452	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
582744007453	Thermostable hemolysin; Region: T_hemolysin; pfam12261
582744007454	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744007455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
582744007456	dimer interface [polypeptide binding]; other site
582744007457	phosphorylation site [posttranslational modification]
582744007458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744007459	ATP binding site [chemical binding]; other site
582744007460	Mg2+ binding site [ion binding]; other site
582744007461	G-X-G motif; other site
582744007462	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
582744007463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744007464	active site
582744007465	phosphorylation site [posttranslational modification]
582744007466	intermolecular recognition site; other site
582744007467	dimerization interface [polypeptide binding]; other site
582744007468	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
582744007469	Walker A motif; other site
582744007470	ATP binding site [chemical binding]; other site
582744007471	Walker B motif; other site
582744007472	arginine finger; other site
582744007473	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
582744007474	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744007475	S-adenosylmethionine binding site [chemical binding]; other site
582744007476	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
582744007477	Outer membrane efflux protein; Region: OEP; pfam02321
582744007478	Outer membrane efflux protein; Region: OEP; pfam02321
582744007479	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012
582744007480	Isochorismatase family; Region: Isochorismatase; pfam00857
582744007481	catalytic triad [active]
582744007482	dimer interface [polypeptide binding]; other site
582744007483	conserved cis-peptide bond; other site
582744007484	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
582744007485	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744007486	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
582744007487	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
582744007488	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
582744007489	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
582744007490	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
582744007491	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
582744007492	active site
582744007493	dimer interface [polypeptide binding]; other site
582744007494	effector binding site; other site
582744007495	TSCPD domain; Region: TSCPD; cl14834
582744007496	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
582744007497	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
582744007498	active site
582744007499	nucleophile elbow; other site
582744007500	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
582744007501	active site
582744007502	NTP binding site [chemical binding]; other site
582744007503	metal binding triad [ion binding]; metal-binding site
582744007504	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
582744007505	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
582744007506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
582744007507	dimer interface [polypeptide binding]; other site
582744007508	conserved gate region; other site
582744007509	putative PBP binding loops; other site
582744007510	ABC-ATPase subunit interface; other site
582744007511	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
582744007512	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744007513	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
582744007514	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
582744007515	Walker A/P-loop; other site
582744007516	ATP binding site [chemical binding]; other site
582744007517	Q-loop/lid; other site
582744007518	ABC transporter signature motif; other site
582744007519	Walker B; other site
582744007520	D-loop; other site
582744007521	H-loop/switch region; other site
582744007522	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
582744007523	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582744007524	DNA-binding site [nucleotide binding]; DNA binding site
582744007525	UTRA domain; Region: UTRA; cl06649
582744007526	Cupin domain; Region: Cupin_2; cl09118
582744007527	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007528	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582744007529	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007530	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
582744007531	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
582744007532	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582744007533	Acyl transferase domain; Region: Acyl_transf_1; cl08282
582744007534	EamA-like transporter family; Region: EamA; cl01037
582744007535	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582744007536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007537	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
582744007538	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
582744007539	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582744007540	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007541	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
582744007542	putative effector binding pocket; other site
582744007543	putative dimerization interface [polypeptide binding]; other site
582744007544	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
582744007545	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
582744007546	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
582744007547	DNA-binding site [nucleotide binding]; DNA binding site
582744007548	RNA-binding motif; other site
582744007549	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
582744007550	BON domain; Region: BON; cl02771
582744007551	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
582744007552	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582744007553	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
582744007554	ligand binding site [chemical binding]; other site
582744007555	flexible hinge region; other site
582744007556	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007557	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
582744007558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744007559	active site
582744007560	phosphorylation site [posttranslational modification]
582744007561	intermolecular recognition site; other site
582744007562	dimerization interface [polypeptide binding]; other site
582744007563	PAS domain S-box; Region: sensory_box; TIGR00229
582744007564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007565	putative active site [active]
582744007566	heme pocket [chemical binding]; other site
582744007567	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007568	metal binding site [ion binding]; metal-binding site
582744007569	active site
582744007570	I-site; other site
582744007571	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
582744007572	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
582744007573	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007574	Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091
582744007575	Putative carbohydrate binding domain; Region: CBM_X; pfam06204
582744007576	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
582744007577	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
582744007578	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
582744007579	Putative carbohydrate binding domain; Region: CBM_X; pfam06204
582744007580	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
582744007581	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
582744007582	Transcriptional regulators [Transcription]; Region: MarR; COG1846
582744007583	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007584	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
582744007585	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
582744007586	FAD binding pocket [chemical binding]; other site
582744007587	FAD binding motif [chemical binding]; other site
582744007588	phosphate binding motif [ion binding]; other site
582744007589	NAD binding pocket [chemical binding]; other site
582744007590	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007591	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582744007592	putative active site [active]
582744007593	heme pocket [chemical binding]; other site
582744007594	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007595	putative active site [active]
582744007596	heme pocket [chemical binding]; other site
582744007597	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007598	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007599	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
582744007600	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
582744007601	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
582744007602	DNA-binding site [nucleotide binding]; DNA binding site
582744007603	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
582744007604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744007605	homodimer interface [polypeptide binding]; other site
582744007606	catalytic residue [active]
582744007607	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
582744007608	Outer membrane efflux protein; Region: OEP; pfam02321
582744007609	Outer membrane efflux protein; Region: OEP; pfam02321
582744007610	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
582744007611	Protein export membrane protein; Region: SecD_SecF; cl14618
582744007612	Protein export membrane protein; Region: SecD_SecF; cl14618
582744007613	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
582744007614	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
582744007615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744007616	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007617	metal binding site [ion binding]; metal-binding site
582744007618	active site
582744007619	I-site; other site
582744007620	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744007621	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
582744007622	putative heme binding pocket [chemical binding]; other site
582744007623	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007624	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007625	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
582744007626	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582744007628	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007629	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
582744007630	dimerization interface [polypeptide binding]; other site
582744007631	Pirin-related protein [General function prediction only]; Region: COG1741
582744007632	Cupin domain; Region: Cupin_2; cl09118
582744007633	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
582744007634	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
582744007635	NADP binding site [chemical binding]; other site
582744007636	Isochorismatase family; Region: Isochorismatase; pfam00857
582744007637	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012
582744007638	catalytic triad [active]
582744007639	dimer interface [polypeptide binding]; other site
582744007640	conserved cis-peptide bond; other site
582744007641	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
582744007642	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
582744007643	active site
582744007644	Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977
582744007645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744007646	putative substrate translocation pore; other site
582744007647	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
582744007648	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cl08294
582744007649	LysR family transcriptional regulator; Provisional; Region: PRK14997
582744007650	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007651	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582744007652	putative effector binding pocket; other site
582744007653	dimerization interface [polypeptide binding]; other site
582744007654	C-term; Region: GreA_GreB; pfam01272
582744007655	MoxR-like ATPases [General function prediction only]; Region: COG0714
582744007656	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744007657	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
582744007658	Protein of unknown function DUF58; Region: DUF58; pfam01882
582744007659	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582744007660	metal ion-dependent adhesion site (MIDAS); other site
582744007661	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
582744007662	metal ion-dependent adhesion site (MIDAS); other site
582744007663	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
582744007664	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
582744007665	putative NAD(P) binding site [chemical binding]; other site
582744007666	dimer interface [polypeptide binding]; other site
582744007667	Transcriptional regulator [Transcription]; Region: LysR; COG0583
582744007668	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007669	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
582744007670	putative effector binding pocket; other site
582744007671	dimerization interface [polypeptide binding]; other site
582744007672	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
582744007673	PAS fold; Region: PAS_3; pfam08447
582744007674	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
582744007675	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007676	metal binding site [ion binding]; metal-binding site
582744007677	active site
582744007678	I-site; other site
582744007679	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744007680	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
582744007681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744007682	active site
582744007683	phosphorylation site [posttranslational modification]
582744007684	intermolecular recognition site; other site
582744007685	dimerization interface [polypeptide binding]; other site
582744007686	CheB methylesterase; Region: CheB_methylest; pfam01339
582744007687	CheD chemotactic sensory transduction; Region: CheD; cl00810
582744007688	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
582744007689	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
582744007690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744007691	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
582744007692	putative CheA interaction surface; other site
582744007693	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007694	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744007695	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007696	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
582744007697	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
582744007698	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
582744007699	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
582744007700	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007701	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744007702	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007703	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
582744007704	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
582744007705	putative CheA interaction surface; other site
582744007706	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729
582744007707	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007708	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
582744007709	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007710	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
582744007711	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
582744007712	putative binding surface; other site
582744007713	active site
582744007714	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
582744007715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
582744007716	ATP binding site [chemical binding]; other site
582744007717	Mg2+ binding site [ion binding]; other site
582744007718	G-X-G motif; other site
582744007719	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
582744007720	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
582744007721	anti sigma factor interaction site; other site
582744007722	regulatory phosphorylation site [posttranslational modification]; other site
582744007723	Response regulator receiver domain; Region: Response_reg; pfam00072
582744007724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
582744007725	active site
582744007726	phosphorylation site [posttranslational modification]
582744007727	intermolecular recognition site; other site
582744007728	dimerization interface [polypeptide binding]; other site
582744007729	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
582744007730	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
582744007731	Outer membrane efflux protein; Region: OEP; pfam02321
582744007732	Outer membrane efflux protein; Region: OEP; pfam02321
582744007733	multidrug efflux protein; Reviewed; Region: PRK09577
582744007734	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
582744007735	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
582744007736	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
582744007737	PAS domain S-box; Region: sensory_box; TIGR00229
582744007738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007739	putative active site [active]
582744007740	heme pocket [chemical binding]; other site
582744007741	PAS fold; Region: PAS_4; pfam08448
582744007742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007743	putative active site [active]
582744007744	heme pocket [chemical binding]; other site
582744007745	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007746	metal binding site [ion binding]; metal-binding site
582744007747	active site
582744007748	I-site; other site
582744007749	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744007750	Protein of unknown function, DUF399; Region: DUF399; cl01139
582744007751	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
582744007752	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
582744007753	classical (c) SDRs; Region: SDR_c; cd05233
582744007754	NAD(P) binding site [chemical binding]; other site
582744007755	active site
582744007756	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
582744007757	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
582744007758	conserved cys residue [active]
582744007759	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
582744007760	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007761	PAS fold; Region: PAS_3; pfam08447
582744007762	putative active site [active]
582744007763	heme pocket [chemical binding]; other site
582744007764	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007765	metal binding site [ion binding]; metal-binding site
582744007766	active site
582744007767	I-site; other site
582744007768	Protein of unknown function DUF45; Region: DUF45; cl00636
582744007769	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
582744007770	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
582744007771	substrate binding pocket [chemical binding]; other site
582744007772	membrane-bound complex binding site; other site
582744007773	hinge residues; other site
582744007774	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007775	PAS fold; Region: PAS_3; pfam08447
582744007776	putative active site [active]
582744007777	heme pocket [chemical binding]; other site
582744007778	PAS fold; Region: PAS_4; pfam08448
582744007779	PAS domain S-box; Region: sensory_box; TIGR00229
582744007780	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744007781	putative active site [active]
582744007782	heme pocket [chemical binding]; other site
582744007783	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007784	metal binding site [ion binding]; metal-binding site
582744007785	active site
582744007786	I-site; other site
582744007787	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744007788	transcriptional regulator; Provisional; Region: PRK10632
582744007789	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
582744007790	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
582744007791	putative effector binding pocket; other site
582744007792	putative dimerization interface [polypeptide binding]; other site
582744007793	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
582744007794	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744007795	NAD(P) binding site [chemical binding]; other site
582744007796	active site
582744007797	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
582744007798	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
582744007799	active site residue [active]
582744007800	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
582744007801	MgtC family; Region: MgtC; cl12207
582744007802	putative chaperone; Provisional; Region: PRK11678
582744007803	Putative exonuclease, RdgC; Region: RdgC; cl01122
582744007804	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
582744007805	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
582744007806	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
582744007807	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
582744007808	Sel1 repeat; Region: Sel1; cl02723
582744007809	Sel1 repeat; Region: Sel1; cl02723
582744007810	Sel1 repeat; Region: Sel1; cl02723
582744007811	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
582744007812	Domain of unknown function DUF21; Region: DUF21; pfam01595
582744007813	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
582744007814	Transporter associated domain; Region: CorC_HlyC; pfam03471
582744007815	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
582744007816	DNA-binding site [nucleotide binding]; DNA binding site
582744007817	RNA-binding motif; other site
582744007818	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
582744007819	rRNA binding site [nucleotide binding]; other site
582744007820	predicted 30S ribosome binding site; other site
582744007821	Cupin domain; Region: Cupin_2; cl09118
582744007822	Helix-turn-helix domain; Region: HTH_18; pfam12833
582744007823	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
582744007824	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
582744007825	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
582744007826	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
582744007827	binding surface
582744007828	TPR motif; other site
582744007829	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
582744007830	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
582744007831	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
582744007832	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
582744007833	RNA polymerase sigma factor; Provisional; Region: PRK12528
582744007834	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
582744007835	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055
582744007836	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
582744007837	FecR protein; Region: FecR; pfam04773
582744007838	Secretin and TonB N terminus short domain; Region: STN; pfam07660
582744007839	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
582744007840	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
582744007841	N-terminal plug; other site
582744007842	ligand-binding site [chemical binding]; other site
582744007843	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
582744007844	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
582744007845	IHF dimer interface [polypeptide binding]; other site
582744007846	IHF - DNA interface [nucleotide binding]; other site
582744007847	coenzyme PQQ biosynthesis protein A; Provisional; Region: PRK14763
582744007848	putative cation:proton antiport protein; Provisional; Region: PRK10669
582744007849	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
582744007850	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744007851	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
582744007852	putative substrate binding site [chemical binding]; other site
582744007853	putative ATP binding site [chemical binding]; other site
582744007854	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
582744007855	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
582744007856	putative ADP-binding pocket [chemical binding]; other site
582744007857	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
582744007858	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
582744007859	active site
582744007860	motif I; other site
582744007861	motif II; other site
582744007862	trehalose synthase; Region: treS_nterm; TIGR02456
582744007863	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
582744007864	Mechanosensitive ion channel; Region: MS_channel; pfam00924
582744007865	H+ Antiporter protein; Region: 2A0121; TIGR00900
582744007866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744007867	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007868	metal binding site [ion binding]; metal-binding site
582744007869	active site
582744007870	I-site; other site
582744007871	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744007872	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744007873	metal binding site [ion binding]; metal-binding site
582744007874	active site
582744007875	I-site; other site
582744007876	Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794
582744007877	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
582744007878	dimerization interface [polypeptide binding]; other site
582744007879	putative DNA binding site [nucleotide binding]; other site
582744007880	putative Zn2+ binding site [ion binding]; other site
582744007881	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
582744007882	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
582744007883	putative acyl-acceptor binding pocket; other site
582744007884	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
582744007885	lysophospholipid transporter LplT; Provisional; Region: PRK11195
582744007886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
582744007887	putative substrate translocation pore; other site
582744007888	Entericidin EcnA/B family; Region: Entericidin; cl02322
582744007889	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
582744007890	active site
582744007891	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744007892	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108
582744007893	coenzyme PQQ biosynthesis protein A; Provisional; Region: PRK14763
582744007894	DoxX; Region: DoxX; cl00976
582744007895	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
582744007896	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
582744007897	putative active site [active]
582744007898	metal binding site [ion binding]; metal-binding site
582744007899	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
582744007900	MltA specific insert domain; Region: MltA; pfam03562
582744007901	3D domain; Region: 3D; cl01439
582744007902	Protein of unknown function (DUF525); Region: DUF525; cl01119
582744007903	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
582744007904	ThiS interaction site; other site
582744007905	putative active site [active]
582744007906	tetramer interface [polypeptide binding]; other site
582744007907	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
582744007908	thiS-thiF/thiG interaction site; other site
582744007909	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
582744007910	binding surface
582744007911	TPR motif; other site
582744007912	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
582744007913	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
582744007914	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
582744007915	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
582744007916	catalytic residue [active]
582744007917	Phosphopantetheine attachment site; Region: PP-binding; cl09936
582744007918	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
582744007919	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
582744007920	dimer interface [polypeptide binding]; other site
582744007921	active site
582744007922	CoA binding pocket [chemical binding]; other site
582744007923	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
582744007924	classical (c) SDRs; Region: SDR_c; cd05233
582744007925	NAD(P) binding site [chemical binding]; other site
582744007926	active site
582744007927	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
582744007928	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
582744007929	putative trimer interface [polypeptide binding]; other site
582744007930	putative CoA binding site [chemical binding]; other site
582744007931	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744007932	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
582744007933	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
582744007934	[2Fe-2S] cluster binding site [ion binding]; other site
582744007935	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
582744007936	alpha subunit interface [polypeptide binding]; other site
582744007937	active site
582744007938	substrate binding site [chemical binding]; other site
582744007939	Fe binding site [ion binding]; other site
582744007940	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647
582744007941	trimer interface [polypeptide binding]; other site
582744007942	active site
582744007943	substrate binding site [chemical binding]; other site
582744007944	CoA binding site [chemical binding]; other site
582744007945	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
582744007946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744007947	S-adenosylmethionine binding site [chemical binding]; other site
582744007948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744007949	CsbD-like; Region: CsbD; cl01272
582744007950	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
582744007951	active site
582744007952	substrate binding site [chemical binding]; other site
582744007953	catalytic site [active]
582744007954	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
582744007955	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
582744007956	Rubredoxin [Energy production and conversion]; Region: COG1773
582744007957	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730
582744007958	iron binding site [ion binding]; other site
582744007959	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
582744007960	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
582744007961	dimer interface [polypeptide binding]; other site
582744007962	substrate binding site [chemical binding]; other site
582744007963	ATP binding site [chemical binding]; other site
582744007964	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
582744007965	thiamine phosphate binding site [chemical binding]; other site
582744007966	active site
582744007967	pyrophosphate binding site [ion binding]; other site
582744007968	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
582744007969	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
582744007970	inhibitor-cofactor binding pocket; inhibition site
582744007971	pyridoxal 5'-phosphate binding site [chemical binding]; other site
582744007972	catalytic residue [active]
582744007973	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
582744007974	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713
582744007975	active site
582744007976	dimer interface [polypeptide binding]; other site
582744007977	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
582744007978	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
582744007979	active site
582744007980	FMN binding site [chemical binding]; other site
582744007981	substrate binding site [chemical binding]; other site
582744007982	3Fe-4S cluster binding site [ion binding]; other site
582744007983	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
582744007984	domain interface; other site
582744007985	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
582744007986	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644
582744007987	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
582744007988	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717
582744007989	substrate binding site [chemical binding]; other site
582744007990	active site
582744007991	primosome assembly protein PriA; Validated; Region: PRK05580
582744007992	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
582744007993	ATP binding site [chemical binding]; other site
582744007994	putative Mg++ binding site [ion binding]; other site
582744007995	Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418
582744007996	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744007997	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
582744007998	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
582744007999	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
582744008000	active site
582744008001	HIGH motif; other site
582744008002	KMSK motif region; other site
582744008003	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
582744008004	tRNA binding surface [nucleotide binding]; other site
582744008005	anticodon binding site; other site
582744008006	Sporulation related domain; Region: SPOR; cl10051
582744008007	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
582744008008	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
582744008009	catalytic residues [active]
582744008010	hinge region; other site
582744008011	alpha helical domain; other site
582744008012	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
582744008013	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
582744008014	NAD(P) binding site [chemical binding]; other site
582744008015	active site
582744008016	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
582744008017	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
582744008018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
582744008019	putative active site [active]
582744008020	heme pocket [chemical binding]; other site
582744008021	PAS fold; Region: PAS_4; pfam08448
582744008022	PAS fold; Region: PAS_4; pfam08448
582744008023	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744008024	metal binding site [ion binding]; metal-binding site
582744008025	active site
582744008026	I-site; other site
582744008027	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744008028	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
582744008029	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
582744008030	glutaminase active site [active]
582744008031	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
582744008032	dimer interface [polypeptide binding]; other site
582744008033	active site
582744008034	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
582744008035	dimer interface [polypeptide binding]; other site
582744008036	active site
582744008037	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173
582744008038	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
582744008039	Substrate binding site [chemical binding]; other site
582744008040	Mg++ binding site [ion binding]; other site
582744008041	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
582744008042	active site
582744008043	substrate binding site [chemical binding]; other site
582744008044	CoA binding site [chemical binding]; other site
582744008045	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
582744008046	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
582744008047	ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401
582744008048	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
582744008049	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
582744008050	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
582744008051	alpha subunit interaction interface [polypeptide binding]; other site
582744008052	Walker A motif; other site
582744008053	ATP binding site [chemical binding]; other site
582744008054	Walker B motif; other site
582744008055	inhibitor binding site; inhibition site
582744008056	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
582744008057	ATP synthase; Region: ATP-synt; cl00365
582744008058	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
582744008059	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
582744008060	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
582744008061	beta subunit interaction interface [polypeptide binding]; other site
582744008062	Walker A motif; other site
582744008063	ATP binding site [chemical binding]; other site
582744008064	Walker B motif; other site
582744008065	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
582744008066	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
582744008067	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
582744008068	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
582744008069	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
582744008070	ATP synthase subunit C; Region: ATP-synt_C; cl00466
582744008071	ATP synthase A chain; Region: ATP-synt_A; cl00413
582744008072	ParB-like partition proteins; Region: parB_part; TIGR00180
582744008073	ParB-like nuclease domain; Region: ParBc; cl02129
582744008074	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582744008075	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
582744008076	P-loop; other site
582744008077	Magnesium ion binding site [ion binding]; other site
582744008078	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
582744008079	Magnesium ion binding site [ion binding]; other site
582744008080	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
582744008081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
582744008082	S-adenosylmethionine binding site [chemical binding]; other site
582744008083	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520
582744008084	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
582744008085	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
582744008086	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
582744008087	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
582744008088	G1 box; other site
582744008089	GTP/Mg2+ binding site [chemical binding]; other site
582744008090	Switch I region; other site
582744008091	G2 box; other site
582744008092	Switch II region; other site
582744008093	G3 box; other site
582744008094	G4 box; other site
582744008095	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
582744008096	membrane protein insertase; Provisional; Region: PRK01318
582744008097	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
582744008098	Domain of unknown function DUF37; Region: DUF37; cl00506
582744008099	Ribonuclease P; Region: Ribonuclease_P; cl00457
582744008100	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic...; Region: INT_Rci; cd00796
582744008101	Phage integrase family; Region: Phage_integrase; pfam00589
582744008102	Int/Topo IB signature motif; other site
582744008103	catalytic residues [active]
582744008104	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582744008105	non-specific DNA binding site [nucleotide binding]; other site
582744008106	salt bridge; other site
582744008107	sequence-specific DNA binding site [nucleotide binding]; other site
582744008108	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100
582744008109	Initiator Replication protein; Region: Rep_3; cl03080
582744008110	ParA-like protein; Provisional; Region: PHA02518
582744008111	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
582744008112	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
582744008113	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
582744008114	active site
582744008115	DNA binding site [nucleotide binding]
582744008116	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
582744008117	Catalytic site [active]
582744008118	Uncharacterised ACR, COG2135; Region: DUF159; cl03646
582744008119	GIY-YIG catalytic domain; Region: GIY-YIG; cl01061
582744008120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457
582744008121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744008122	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
582744008123	PemK-like protein; Region: PemK; cl00995
582744008124	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
582744008125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
582744008126	metal binding site [ion binding]; metal-binding site
582744008127	active site
582744008128	I-site; other site
582744008129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
582744008130	DNA topoisomerase I; Validated; Region: PRK05582
582744008131	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
582744008132	active site
582744008133	interdomain interaction site; other site
582744008134	putative metal-binding site [ion binding]; other site
582744008135	nucleotide binding site [chemical binding]; other site
582744008136	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
582744008137	domain I; other site
582744008138	DNA binding groove [nucleotide binding]
582744008139	phosphate binding site [ion binding]; other site
582744008140	domain II; other site
582744008141	domain III; other site
582744008142	nucleotide binding site [chemical binding]; other site
582744008143	catalytic site [active]
582744008144	domain IV; other site
582744008145	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
582744008146	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
582744008147	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
582744008148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744008149	cofactor binding site; other site
582744008150	DNA binding site [nucleotide binding]
582744008151	substrate interaction site [chemical binding]; other site
582744008152	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
582744008153	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744008154	Walker A motif; other site
582744008155	ATP binding site [chemical binding]; other site
582744008156	Walker B motif; other site
582744008157	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744008158	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
582744008159	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
582744008160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
582744008161	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication...; Region: TOPRIM_primases; cd01029
582744008162	active site
582744008163	metal binding site [ion binding]; metal-binding site
582744008164	interdomain interaction site; other site
582744008165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
582744008166	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744008167	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744008168	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882
582744008169	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
582744008170	Domain of unknown function DUF87; Region: DUF87; pfam01935
582744008171	AAA-like domain; Region: AAA_10; pfam12846
582744008172	ParB-like partition proteins; Region: parB_part; TIGR00180
582744008173	ParB-like nuclease domain; Region: ParBc; cl02129
582744008174	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
582744008175	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
582744008176	P-loop; other site
582744008177	Magnesium ion binding site [ion binding]; other site
582744008178	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
582744008179	Magnesium ion binding site [ion binding]; other site
582744008180	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
582744008181	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
582744008182	VirB7 interaction site; other site
582744008183	VirB8 protein; Region: VirB8; cl01500
582744008184	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
582744008185	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
582744008186	conjugal transfer protein TrbE; Provisional; Region: PRK13891
582744008187	VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
582744008188	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888
582744008189	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
582744008190	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
582744008191	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130
582744008192	ATP binding site [chemical binding]; other site
582744008193	Walker A motif; other site
582744008194	hexamer interface [polypeptide binding]; other site
582744008195	Walker B motif; other site
582744008196	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
582744008197	ligand binding site [chemical binding]; other site
582744008198	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
582744008199	type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520
582744008200	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
582744008201	Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864
582744008202	Type IV pilus biogenesis; Region: Pilus_PilP; cl11837
582744008203	Type II/IV secretion system protein; Region: GSPII_E; pfam00437
582744008204	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744008205	Walker A motif; other site
582744008206	ATP binding site [chemical binding]; other site
582744008207	Walker B motif; other site
582744008208	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744008209	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
582744008210	PilS N terminal; Region: PilS; pfam08805
582744008211	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744008212	Walker A motif; other site
582744008213	ATP binding site [chemical binding]; other site
582744008214	Walker B motif; other site
582744008215	PilM; Region: PilM; pfam07419
582744008216	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
582744008217	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
582744008218	Walker A motif; other site
582744008219	ATP binding site [chemical binding]; other site
582744008220	Walker B motif; other site
582744008221	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
582744008222	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
582744008223	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
582744008224	non-specific DNA binding site [nucleotide binding]; other site
582744008225	salt bridge; other site
582744008226	sequence-specific DNA binding site [nucleotide binding]; other site
582744008227	Predicted ATPase [General function prediction only]; Region: COG4637
582744008228	integrase; Provisional; Region: PRK09692
582744008229	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
582744008230	active site
582744008231	Int/Topo IB signature motif; other site
582744008232	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
582744008233	Zonular occludens toxin (Zot); Region: Zot; cl01706
582744008234	Protein of unknown function (DUF2523); Region: DUF2523; cl10291